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Conserved domains on  [gi|446471523|ref|WP_000549377|]
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MULTISPECIES: penicillin-binding protein [Bacillus]

Protein Classification

penicillin-binding protein( domain architecture ID 11433624)

PASTA domain-containing penicillin-binding protein may catalyze key steps in the synthesis of peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains

Gene Ontology:  GO:0008658|GO:0016020|GO:0009252
PubMed:  32762868|32442851

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 5-572 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 562.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   5 QTNKGARYMMVAFIVLFLTMLLRIFYIQavgVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRVVVNL 84
Cdd:COG0768    9 LFRRRLLLLFLLVLLLFLLLVGRLFYLQ---VVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  85 KgkdKVKNSDETAQQLADVLEIDKEEVIKNFHEGRTqvEIGKIGRNLSRETKEKIRKLKIPGVSFMPEKARVYPNEDFAS 164
Cdd:COG0768   86 E---EVKDPEETAEKLAKLLGLDPEELRKKLKKKSR--FPVYLKRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGELAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 165 YILGFARPDDKGNTEGKFGLEKSLDKYLRSTNGNIEYVGTRKGIPLtNDIGKVEPAKHGNNVYLTLDKQINSFLEEAMNK 244
Cdd:COG0768  161 HVLGYVGEINGGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVI-RDLGEEKPPVPGKDLVLTIDSDLQKIAEEALKK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 245 AQQHYDPSMLIGIIANPKTGKVLAMSSKPSYNPN---KGDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKEYFQ 321
Cdd:COG0768  240 AVEEYKAKSGAVVVMDPKTGEILAMASYPSFDPNlfvGGPDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTTFD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 322 -SGKYSVGSTDIKDHNGGfGWGSITFDEGFERSSNVAFSILEDQlLKPNKFKQYMNKFGFNQKTGIDLPGESKnTLLLNT 400
Cdd:COG0768  320 cPGYYRVGGRTIRDWDRG-GHGTLTLTEALAKSSNVGFYKLALR-LGIDKLYDYLKKFGLGQKTGIDLPGEAS-GLLPSP 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 401 Q----IQQVTTSFGQGSTVTPIQLIQAATAIANDGKMMQPYIVDKVVNPTNKQVimENQPKEIGNPIKKETADKVRSLME 476
Cdd:COG0768  397 KrwypGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVV--KEEPEVLRRVISPETAETVREGME 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 477 RVITSSKGTGTMYKVDGYPIGGKTGTAQIPNPENGRYMEGKenYIFSFLGMAPIDDPELIVYLAIKQPklKGDEYGAQPL 556
Cdd:COG0768  475 GVVNEPGGTARRAAIPGYRVAGKTGTAQVVDIGNGGYYKGR--HIASFVGFAPADNPRYAVAVVVENP--GGGAYGGTVA 550

                        570
                 ....*....|....*.
gi 446471523 557 AEIFKPVIKNSLEYLK 572
Cdd:COG0768  551 APVFREIMEAYLRLLG 566
PASTA_Pbp2x-like_2 cd06575
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ...
 647-700 6.60e-16

PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


:

Pssm-ID: 119326 [Multi-domain]  Cd Length: 54  Bit Score: 72.10  E-value: 6.60e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446471523 647 KMPNIKGWSMRDVMYFSKLLKLDLKTSGTGYVTNQSIEKGKDLQEGDTLKLELE 700
Cdd:cd06575    1 TMPDLTGWSKRDALKLLELLGLKVKFSGSGYVVSQSIAPGTKVKKGTTITVTLK 54
PASTA_Pbp2x-like_1 cd06576
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ...
 591-644 6.35e-12

PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


:

Pssm-ID: 119327 [Multi-domain]  Cd Length: 55  Bit Score: 60.99  E-value: 6.35e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446471523 591 KVQSYVNQSMGTVEKSAEKEKLQPVILGEG-KIIKQYPQSGEVMSEGDRIFLLGN 644
Cdd:cd06576    1 KVPDVTGKSVEEAKKELKEAGLQPVVIGNGkKVKKQSPKPGEKVLEGSKVLLYTD 55
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 5-572 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 562.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   5 QTNKGARYMMVAFIVLFLTMLLRIFYIQavgVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRVVVNL 84
Cdd:COG0768    9 LFRRRLLLLFLLVLLLFLLLVGRLFYLQ---VVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  85 KgkdKVKNSDETAQQLADVLEIDKEEVIKNFHEGRTqvEIGKIGRNLSRETKEKIRKLKIPGVSFMPEKARVYPNEDFAS 164
Cdd:COG0768   86 E---EVKDPEETAEKLAKLLGLDPEELRKKLKKKSR--FPVYLKRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGELAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 165 YILGFARPDDKGNTEGKFGLEKSLDKYLRSTNGNIEYVGTRKGIPLtNDIGKVEPAKHGNNVYLTLDKQINSFLEEAMNK 244
Cdd:COG0768  161 HVLGYVGEINGGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVI-RDLGEEKPPVPGKDLVLTIDSDLQKIAEEALKK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 245 AQQHYDPSMLIGIIANPKTGKVLAMSSKPSYNPN---KGDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKEYFQ 321
Cdd:COG0768  240 AVEEYKAKSGAVVVMDPKTGEILAMASYPSFDPNlfvGGPDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTTFD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 322 -SGKYSVGSTDIKDHNGGfGWGSITFDEGFERSSNVAFSILEDQlLKPNKFKQYMNKFGFNQKTGIDLPGESKnTLLLNT 400
Cdd:COG0768  320 cPGYYRVGGRTIRDWDRG-GHGTLTLTEALAKSSNVGFYKLALR-LGIDKLYDYLKKFGLGQKTGIDLPGEAS-GLLPSP 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 401 Q----IQQVTTSFGQGSTVTPIQLIQAATAIANDGKMMQPYIVDKVVNPTNKQVimENQPKEIGNPIKKETADKVRSLME 476
Cdd:COG0768  397 KrwypGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVV--KEEPEVLRRVISPETAETVREGME 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 477 RVITSSKGTGTMYKVDGYPIGGKTGTAQIPNPENGRYMEGKenYIFSFLGMAPIDDPELIVYLAIKQPklKGDEYGAQPL 556
Cdd:COG0768  475 GVVNEPGGTARRAAIPGYRVAGKTGTAQVVDIGNGGYYKGR--HIASFVGFAPADNPRYAVAVVVENP--GGGAYGGTVA 550

                        570
                 ....*....|....*.
gi 446471523 557 AEIFKPVIKNSLEYLK 572
Cdd:COG0768  551 APVFREIMEAYLRLLG 566
strep_PBP2X NF038271
penicillin-binding protein PBP2X;
13-689 7.45e-118

penicillin-binding protein PBP2X;


Pssm-ID: 468442 [Multi-domain]  Cd Length: 748  Bit Score: 370.89  E-value: 7.45e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  13 MMVAFIVLFLTMLLRIFYIQAVGVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRV-------VVNLK 85
Cdd:NF038271  26 LMILTVFLFFVFLINFAIIIGTDSKFGVDLSEGAKKVYQTTVTVQAKRGTIYDRNGNPIAEDSTTYSIyaiidksYVSAT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  86 GKD-KVKNS--DETAQQLADVLEIDKEEVIKNFH-EGRTQVEIGKIGRNLSRETKEKIRK----LKIPGVSFMPEKARVY 157
Cdd:NF038271 106 GEKlYVQPSqfDKVAEILNKHLGMEKDYVLKQLKqKKLKQVSFGTKGSGISYSTMTAIKEamekAGIKGIAFTTSPGRMY 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 158 PNEDFASYILGFARP-DDKGNT---EGKFGLEKSLDKYLRSTNGNIEYVGTRKG--IPLTNDIgkVEPAKHGNNVYLTLD 231
Cdd:NF038271 186 PNGTFASQFIGLAQLvENKDGSkslVGKTGLEASLNDILSGQDGKVTYEKDKNGniLLGTETV--VKKAVDGKDVYTTLS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 232 KQINSFLEEAMN----KAQQHYDPSMLIgiiaNPKTGKVLAMSSKPSYNPNK----GDIEYFLNDPI-ANAYEPGSTMKV 302
Cdd:NF038271 264 APLQTYLETQMDvfqeKAKGKYASATLV----NAKTGEILATTQRPTYNADTkeglDKKDLNWNNLLyQTNYEPGSTMKV 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 303 FTLAAAINEGVYN-GKEYFQSGKYSVGSTDIKDH--NGGFGWG-SITFDEGFERSSNVAFSILEdQLLKPNKFKQYMNKF 378
Cdd:NF038271 340 MTLASAIDNGTFNpNETYSNSNGLTIADATINDWdvNEGLSTGqYMTYAQGFAYSSNVGMTLLE-QKMGDDKWLNYLSKF 418

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 379 GFNQKTGIDLPGESKNTLLLNTQIQQVTTSFGQGSTVTPIQLIQAATAIANDGKMMQPYIVDKVVNPtNKQVIMENQPKE 458
Cdd:NF038271 419 KFGLPTRFGMGDESSGILPSDNIVTIAMSSFGQGISVTQVQMLRAFSAISNDGVMLEPKFISAIYDP-NTGTARKSKKEV 497

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 459 IGNPIKKETADKVRSLMERVitsskGT----GTMY---------KVDGYPIGGKTGTAQIPNPENGRYMEGKENYIFSFL 525
Cdd:NF038271 498 VGKPVSKDAASQTRNYMVTV-----GTdpyyGTLYskttggpiiQVGNYSVAVKSGTAQIAKEDGSGYLEGENNYIYSVV 572

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 526 GMAPIDDPELIVYLAIKQPKlkgdEYGAQPLAEIFKPVIKnslEYLKVKP---YTEKQIVDATKQSQLKVQSYVNQSMGT 602
Cdd:NF038271 573 AMVPAEDPDFIMYVTVQQPE----HFSPLFWQDVVNPVLE---EAMLMKDtlnLTAPALDDVTKETEYKLPDIIGKSPGD 645

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 603 VEKSAEKEKLQPVILGEGKIIKQYPQS-GEVMSEGDRIFLLGNN-AKMPNIKGWSMRDVMYFSKL--LKLDLKTSGTGYV 678
Cdd:NF038271 646 TADELRRNLVQPIVLGTGSKIKKVSVKaGSNLKANQQILLLTDKfEELPDMYGWTKENVEKFAKWtgIEVTFKGSGSGKV 725

                        730
                 ....*....|.
gi 446471523 679 TNQSIEKGKDL 689
Cdd:NF038271 726 VKQSVDVGTSL 736
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 11-537 7.56e-98

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 313.69  E-value: 7.56e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   11 RYMMVAF--IVLFLTMLLRIFYIQavgVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRVVVNlkgKD 88
Cdd:TIGR03423   2 RALVLGGlvLALFGVLAARLFYLQ---VIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIV---PE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   89 KVKNSDETAQQLADVLEIDKEEVIKNFHEGRTQ---VEIgKIGRNLSRETKEKI--RKLKIPGVSFMPEKARVYPNEDFA 163
Cdd:TIGR03423  76 KVDDLDATLDRLAKLLDLDPEDIARFLKELKRSrrfEPI-PLKSDLTEEEVARFavNQYRLPGVEIEARLKRYYPYGELA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  164 SYILGF-ARPDDK------------GNTEGKFGLEKSLDKYLRSTNGNIEYVgtrkgiplTNDIGKV------EPAKHGN 224
Cdd:TIGR03423 155 AHVLGYvGEINEEdlerlepanyagGDYIGKSGIEKYYEDELRGKPGYREVE--------VNARGRVirtlsrVPPVPGK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  225 NVYLTLDKQINSFLEEAMNKAqqhydpsmlIG-IIA-NPKTGKVLAMSSKPSYNPNK--GDI---EY----------FLN 287
Cdd:TIGR03423 227 DLVLTIDARLQQAAEKALGGR---------RGaVVVmDPRTGEILAMVSTPSFDPNLfvDGIsskDYkallndpdrpLLN 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  288 DPIANAYEPGSTMKVFTLAAAINEGVYNGKE-YFQSGKYSVGSTDIKDHNGGfGWGSITFDEGFERSSNVAFSILEDQLl 366
Cdd:TIGR03423 298 RAIQGVYPPGSTFKPVVALAALEEGVITPETrIYCPGYFQLGGRRFRCWKRG-GHGRVDLRKAIEESCDVYFYQLALRL- 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  367 KPNKFKQYMNKFGFNQKTGIDLPGESKNTL------------------LLNTQIqqvttsfGQGS-TVTPIQLIQAATAI 427
Cdd:TIGR03423 376 GIDKIAEYAKRFGFGQKTGIDLPGEKSGLVpsrewkrkrfgqpwypgdTLNVSI-------GQGYvLVTPLQLAVATAAL 448

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  428 ANDGKMMQPYIVDKVVNPTNKqVIMENQPKEIGN-PIKKETADKVRSLMERVITSSKGTGTMYKVD-GYPIGGKTGTAQI 505
Cdd:TIGR03423 449 ANGGKLYKPHLVKSIEDPDGG-VVRRTEPEVLRPlPISPENLDVVREGMRDVVNGPGGTARRARLGlPYKMAGKTGTAQV 527

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 446471523  506 PNP-ENGRYMEGKENYIF----SFLGMAPIDDPELIV 537
Cdd:TIGR03423 528 VSLkQGEKYDAEQIPERLrdhaLFVAFAPYDNPKIAV 564
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 257-565 3.37e-82

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 262.74  E-value: 3.37e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  257 IIANPKTGKVLAMSSKPSYNPNkGDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKE-YFQSGKYSVGSTDIKDH 335
Cdd:pfam00905   4 VVLDPKTGEVLAMVGKPSYDPN-GFIGPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDEtIFDWPGKQQGGKSIGDW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  336 NGGfGWGSITFDEGFERSSNVAFSILEdQLLKPNKFKQYMNKFGFNQKTGIDLPGESkNTLLLNTQIQQVTTSFGQGSTV 415
Cdd:pfam00905  83 NQD-QVGIGTLRQALEYSSNWYMQKLA-QKLGADKLRSYLKKFGYGNKTGIGLPGEN-AGYLTPYWLEGATASFGIGLTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  416 TPIQLIQAATAIANDGKMMQPYIVDKVVNptnkqviMENQPKEIGNPIKKETADKVRSLMERVITSSKGTGTMyKVDGYP 495
Cdd:pfam00905 160 TPLQQAQAYAAIANGGKLVPPHLVKSIED-------KVDPKVLNKLPISKSTAEKVKDMLRLVVNDGTGTGTA-AVPGYK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  496 IGGKTGTAQIPNPENGRYmeGKENYIFSFLGMAPIDDPELIVYLAIKQPKlkgDEYGAQPLAEIFKPVIK 565
Cdd:pfam00905 232 VAGKTGTAQVAGPKGGGY--YDGAQIGWFVGYAPADNPKYAFAVLIDDPK---RYYGGKVAAPIFKDILE 296
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 18-575 1.35e-41

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 159.99  E-value: 1.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  18 IVLFLT-MLLRIFYIQAVG---VVHNVDVKDLANEQhnkngvLEANRGTIYDQTGKVLVQDSATYRV-----VVNLKGKD 88
Cdd:PRK15105  30 ILLALVfLLGRVAWLQVINpdmLVREGDMRSLRVQE------VSTSRGMITDRSGRPLAVSVPVKAIwadpkEVHDAGGI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  89 KVknsDETAQQLADVLEIDKEEV---IKNFHEGRtqveIGKIGRNLSRETKEKIRKLKIPGVSFMPEKARVYPNEDFASY 165
Cdd:PRK15105 104 SV---DDRWKALADALNIPLDQLsarINANPKGR----FIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAH 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 166 ILGFARPDDKGNTegkfGLEKSLDKYLRSTNGNIEYVGTRKGiPLTNDIGKVEpAKHGNNVYLTLDKQINSFLEEAMNKA 245
Cdd:PRK15105 177 LIGFTNVDSQGIE----GVEKSFDKWLTGQPGERIVRKDRYG-RVIEDISSTD-SQAAHNLALSIDERLQALVYRELNNA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 246 QQHYDPSMLIGIIANPKTGKVLAMSSKPSYNPNK---GDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKEYFQS 322
Cdd:PRK15105 251 VAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNlsgTPKDAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNT 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 323 GKYSVGSTDIKDHNggfGWGSITFDEGFERSSNVAFSILedQLLKP-NKFKQYMNKFGFNQKTGIDLPGESKNtLLLNTQ 401
Cdd:PRK15105 331 VPYRINGHEIKDVA---RYSELTLTGVLQKSSNVGVSKL--ALAMPsSALVDTYSRFGLGKATNLGLVGERSG-LYPQKQ 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 402 ----IQQVTTSFGQGSTVTPIQLIQAATAIANDGkMMQPYIVDKVVNPTNKQVIMenqPKEIgnpikketADKVRSLMER 477
Cdd:PRK15105 405 rwsdIERATFSFGYGLMVTPLQLARVYATIGSYG-IYRPLSITKVDPPVPGERVF---PESI--------VRTVVHMMES 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 478 VITSSKGtGTMYKVDGYPIGGKTGTAQIPNPEnGRYMegkENYIFSFLGMAPIDDPELIVYLAIKQPKlKGDEYGAQPLA 557
Cdd:PRK15105 473 VALPGGG-GVKAAIKGYRIAIKTGTAKKVGPD-GRYI---NKYIAYTAGVAPASQPRFALVVVINDPQ-AGKYYGGAVSA 546

                        570
                 ....*....|....*...
gi 446471523 558 EIFKPVIKNSLEYLKVKP 575
Cdd:PRK15105 547 PVFGAIMGGVLRTMNIEP 564
PASTA_Pbp2x-like_2 cd06575
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ...
 647-700 6.60e-16

PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119326 [Multi-domain]  Cd Length: 54  Bit Score: 72.10  E-value: 6.60e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446471523 647 KMPNIKGWSMRDVMYFSKLLKLDLKTSGTGYVTNQSIEKGKDLQEGDTLKLELE 700
Cdd:cd06575    1 TMPDLTGWSKRDALKLLELLGLKVKFSGSGYVVSQSIAPGTKVKKGTTITVTLK 54
PASTA_Pbp2x-like_1 cd06576
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ...
 591-644 6.35e-12

PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119327 [Multi-domain]  Cd Length: 55  Bit Score: 60.99  E-value: 6.35e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446471523 591 KVQSYVNQSMGTVEKSAEKEKLQPVILGEG-KIIKQYPQSGEVMSEGDRIFLLGN 644
Cdd:cd06576    1 KVPDVTGKSVEEAKKELKEAGLQPVVIGNGkKVKKQSPKPGEKVLEGSKVLLYTD 55
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 647-699 1.31e-05

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 43.38  E-value: 1.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446471523  647 KMPNIKGWSMRDVMyfSKLLKLDLK---------TSGTGYVTNQSIEKGKDLQEGDTLKLEL 699
Cdd:pfam03793   2 TVPDVVGLSLEEAK--KLLEALGLKvgtveeysdDVGEGTVISQSPPAGTKVKKGSKVTLTV 61
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
588-697 3.19e-05

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 47.10  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 588 SQLKVQSYVNQSMGTVEKSAEKEKLQPVILGE--------GKIIKQYPQSGEVMSEGDRIFL---LGNNA-KMPNIKGWS 655
Cdd:NF033483 363 KEVTVPDVVGKTEAEAKEALEKAGLKVGKVEEeysddveeGKVISTDPEAGTRVKEGSTVTLvvsKGPEKvKVPDLTGKS 442

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446471523 656 MRDVMyfSKLLKLDLK----------TSGTGYVTNQSIEKGKDLQEGDTLKL 697
Cdd:NF033483 443 LDEAK--KALEDAGLKvgtieeeysdDVPKGTVISQDPAAGTEVDKGTTVTL 492
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 591-641 9.32e-04

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 37.99  E-value: 9.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446471523  591 KVQSYVNQSMGTVEKSAEKEKLQPVI-------LGEGKIIKQYPQSGEVMSEGDRIFL 641
Cdd:pfam03793   2 TVPDVVGLSLEEAKKLLEALGLKVGTveeysddVGEGTVISQSPPAGTKVKKGSKVTL 59
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
572-699 7.36e-03

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 39.39  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 572 KVKPYTEKQIVDATKQsqLKVQSYVNqSMGTVEKSAEKEKlqpvilgeGKIIKQYPQSGEVMSEGDRIFL---LGNNA-K 647
Cdd:NF033483 434 KVPDLTGKSLDEAKKA--LEDAGLKV-GTIEEEYSDDVPK--------GTVISQDPAAGTEVDKGTTVTLtvsKGPEPvT 502

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446471523 648 MPNIKGWSMRDVMyfSKLLKLDLKTSGT----------GYVTNQSIEKGKDLQEGDTLKLEL 699
Cdd:NF033483 503 VPDVTGMSEEEAK--SALESAGLKVGVEeeevssdvpaGTVISQSPAAGTEVAKGSTVTLTV 562
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 5-572 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 562.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   5 QTNKGARYMMVAFIVLFLTMLLRIFYIQavgVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRVVVNL 84
Cdd:COG0768    9 LFRRRLLLLFLLVLLLFLLLVGRLFYLQ---VVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  85 KgkdKVKNSDETAQQLADVLEIDKEEVIKNFHEGRTqvEIGKIGRNLSRETKEKIRKLKIPGVSFMPEKARVYPNEDFAS 164
Cdd:COG0768   86 E---EVKDPEETAEKLAKLLGLDPEELRKKLKKKSR--FPVYLKRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGELAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 165 YILGFARPDDKGNTEGKFGLEKSLDKYLRSTNGNIEYVGTRKGIPLtNDIGKVEPAKHGNNVYLTLDKQINSFLEEAMNK 244
Cdd:COG0768  161 HVLGYVGEINGGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVI-RDLGEEKPPVPGKDLVLTIDSDLQKIAEEALKK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 245 AQQHYDPSMLIGIIANPKTGKVLAMSSKPSYNPN---KGDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKEYFQ 321
Cdd:COG0768  240 AVEEYKAKSGAVVVMDPKTGEILAMASYPSFDPNlfvGGPDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTTFD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 322 -SGKYSVGSTDIKDHNGGfGWGSITFDEGFERSSNVAFSILEDQlLKPNKFKQYMNKFGFNQKTGIDLPGESKnTLLLNT 400
Cdd:COG0768  320 cPGYYRVGGRTIRDWDRG-GHGTLTLTEALAKSSNVGFYKLALR-LGIDKLYDYLKKFGLGQKTGIDLPGEAS-GLLPSP 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 401 Q----IQQVTTSFGQGSTVTPIQLIQAATAIANDGKMMQPYIVDKVVNPTNKQVimENQPKEIGNPIKKETADKVRSLME 476
Cdd:COG0768  397 KrwypGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVV--KEEPEVLRRVISPETAETVREGME 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 477 RVITSSKGTGTMYKVDGYPIGGKTGTAQIPNPENGRYMEGKenYIFSFLGMAPIDDPELIVYLAIKQPklKGDEYGAQPL 556
Cdd:COG0768  475 GVVNEPGGTARRAAIPGYRVAGKTGTAQVVDIGNGGYYKGR--HIASFVGFAPADNPRYAVAVVVENP--GGGAYGGTVA 550

                        570
                 ....*....|....*.
gi 446471523 557 AEIFKPVIKNSLEYLK 572
Cdd:COG0768  551 APVFREIMEAYLRLLG 566
strep_PBP2X NF038271
penicillin-binding protein PBP2X;
13-689 7.45e-118

penicillin-binding protein PBP2X;


Pssm-ID: 468442 [Multi-domain]  Cd Length: 748  Bit Score: 370.89  E-value: 7.45e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  13 MMVAFIVLFLTMLLRIFYIQAVGVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRV-------VVNLK 85
Cdd:NF038271  26 LMILTVFLFFVFLINFAIIIGTDSKFGVDLSEGAKKVYQTTVTVQAKRGTIYDRNGNPIAEDSTTYSIyaiidksYVSAT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  86 GKD-KVKNS--DETAQQLADVLEIDKEEVIKNFH-EGRTQVEIGKIGRNLSRETKEKIRK----LKIPGVSFMPEKARVY 157
Cdd:NF038271 106 GEKlYVQPSqfDKVAEILNKHLGMEKDYVLKQLKqKKLKQVSFGTKGSGISYSTMTAIKEamekAGIKGIAFTTSPGRMY 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 158 PNEDFASYILGFARP-DDKGNT---EGKFGLEKSLDKYLRSTNGNIEYVGTRKG--IPLTNDIgkVEPAKHGNNVYLTLD 231
Cdd:NF038271 186 PNGTFASQFIGLAQLvENKDGSkslVGKTGLEASLNDILSGQDGKVTYEKDKNGniLLGTETV--VKKAVDGKDVYTTLS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 232 KQINSFLEEAMN----KAQQHYDPSMLIgiiaNPKTGKVLAMSSKPSYNPNK----GDIEYFLNDPI-ANAYEPGSTMKV 302
Cdd:NF038271 264 APLQTYLETQMDvfqeKAKGKYASATLV----NAKTGEILATTQRPTYNADTkeglDKKDLNWNNLLyQTNYEPGSTMKV 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 303 FTLAAAINEGVYN-GKEYFQSGKYSVGSTDIKDH--NGGFGWG-SITFDEGFERSSNVAFSILEdQLLKPNKFKQYMNKF 378
Cdd:NF038271 340 MTLASAIDNGTFNpNETYSNSNGLTIADATINDWdvNEGLSTGqYMTYAQGFAYSSNVGMTLLE-QKMGDDKWLNYLSKF 418

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 379 GFNQKTGIDLPGESKNTLLLNTQIQQVTTSFGQGSTVTPIQLIQAATAIANDGKMMQPYIVDKVVNPtNKQVIMENQPKE 458
Cdd:NF038271 419 KFGLPTRFGMGDESSGILPSDNIVTIAMSSFGQGISVTQVQMLRAFSAISNDGVMLEPKFISAIYDP-NTGTARKSKKEV 497

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 459 IGNPIKKETADKVRSLMERVitsskGT----GTMY---------KVDGYPIGGKTGTAQIPNPENGRYMEGKENYIFSFL 525
Cdd:NF038271 498 VGKPVSKDAASQTRNYMVTV-----GTdpyyGTLYskttggpiiQVGNYSVAVKSGTAQIAKEDGSGYLEGENNYIYSVV 572

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 526 GMAPIDDPELIVYLAIKQPKlkgdEYGAQPLAEIFKPVIKnslEYLKVKP---YTEKQIVDATKQSQLKVQSYVNQSMGT 602
Cdd:NF038271 573 AMVPAEDPDFIMYVTVQQPE----HFSPLFWQDVVNPVLE---EAMLMKDtlnLTAPALDDVTKETEYKLPDIIGKSPGD 645

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 603 VEKSAEKEKLQPVILGEGKIIKQYPQS-GEVMSEGDRIFLLGNN-AKMPNIKGWSMRDVMYFSKL--LKLDLKTSGTGYV 678
Cdd:NF038271 646 TADELRRNLVQPIVLGTGSKIKKVSVKaGSNLKANQQILLLTDKfEELPDMYGWTKENVEKFAKWtgIEVTFKGSGSGKV 725

                        730
                 ....*....|.
gi 446471523 679 TNQSIEKGKDL 689
Cdd:NF038271 726 VKQSVDVGTSL 736
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 11-537 7.56e-98

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 313.69  E-value: 7.56e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   11 RYMMVAF--IVLFLTMLLRIFYIQavgVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRVVVNlkgKD 88
Cdd:TIGR03423   2 RALVLGGlvLALFGVLAARLFYLQ---VIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIV---PE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   89 KVKNSDETAQQLADVLEIDKEEVIKNFHEGRTQ---VEIgKIGRNLSRETKEKI--RKLKIPGVSFMPEKARVYPNEDFA 163
Cdd:TIGR03423  76 KVDDLDATLDRLAKLLDLDPEDIARFLKELKRSrrfEPI-PLKSDLTEEEVARFavNQYRLPGVEIEARLKRYYPYGELA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  164 SYILGF-ARPDDK------------GNTEGKFGLEKSLDKYLRSTNGNIEYVgtrkgiplTNDIGKV------EPAKHGN 224
Cdd:TIGR03423 155 AHVLGYvGEINEEdlerlepanyagGDYIGKSGIEKYYEDELRGKPGYREVE--------VNARGRVirtlsrVPPVPGK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  225 NVYLTLDKQINSFLEEAMNKAqqhydpsmlIG-IIA-NPKTGKVLAMSSKPSYNPNK--GDI---EY----------FLN 287
Cdd:TIGR03423 227 DLVLTIDARLQQAAEKALGGR---------RGaVVVmDPRTGEILAMVSTPSFDPNLfvDGIsskDYkallndpdrpLLN 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  288 DPIANAYEPGSTMKVFTLAAAINEGVYNGKE-YFQSGKYSVGSTDIKDHNGGfGWGSITFDEGFERSSNVAFSILEDQLl 366
Cdd:TIGR03423 298 RAIQGVYPPGSTFKPVVALAALEEGVITPETrIYCPGYFQLGGRRFRCWKRG-GHGRVDLRKAIEESCDVYFYQLALRL- 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  367 KPNKFKQYMNKFGFNQKTGIDLPGESKNTL------------------LLNTQIqqvttsfGQGS-TVTPIQLIQAATAI 427
Cdd:TIGR03423 376 GIDKIAEYAKRFGFGQKTGIDLPGEKSGLVpsrewkrkrfgqpwypgdTLNVSI-------GQGYvLVTPLQLAVATAAL 448

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  428 ANDGKMMQPYIVDKVVNPTNKqVIMENQPKEIGN-PIKKETADKVRSLMERVITSSKGTGTMYKVD-GYPIGGKTGTAQI 505
Cdd:TIGR03423 449 ANGGKLYKPHLVKSIEDPDGG-VVRRTEPEVLRPlPISPENLDVVREGMRDVVNGPGGTARRARLGlPYKMAGKTGTAQV 527

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 446471523  506 PNP-ENGRYMEGKENYIF----SFLGMAPIDDPELIV 537
Cdd:TIGR03423 528 VSLkQGEKYDAEQIPERLrdhaLFVAFAPYDNPKIAV 564
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 257-565 3.37e-82

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 262.74  E-value: 3.37e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  257 IIANPKTGKVLAMSSKPSYNPNkGDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKE-YFQSGKYSVGSTDIKDH 335
Cdd:pfam00905   4 VVLDPKTGEVLAMVGKPSYDPN-GFIGPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDEtIFDWPGKQQGGKSIGDW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  336 NGGfGWGSITFDEGFERSSNVAFSILEdQLLKPNKFKQYMNKFGFNQKTGIDLPGESkNTLLLNTQIQQVTTSFGQGSTV 415
Cdd:pfam00905  83 NQD-QVGIGTLRQALEYSSNWYMQKLA-QKLGADKLRSYLKKFGYGNKTGIGLPGEN-AGYLTPYWLEGATASFGIGLTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  416 TPIQLIQAATAIANDGKMMQPYIVDKVVNptnkqviMENQPKEIGNPIKKETADKVRSLMERVITSSKGTGTMyKVDGYP 495
Cdd:pfam00905 160 TPLQQAQAYAAIANGGKLVPPHLVKSIED-------KVDPKVLNKLPISKSTAEKVKDMLRLVVNDGTGTGTA-AVPGYK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  496 IGGKTGTAQIPNPENGRYmeGKENYIFSFLGMAPIDDPELIVYLAIKQPKlkgDEYGAQPLAEIFKPVIK 565
Cdd:pfam00905 232 VAGKTGTAQVAGPKGGGY--YDGAQIGWFVGYAPADNPKYAFAVLIDDPK---RYYGGKVAAPIFKDILE 296
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 18-575 1.35e-41

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 159.99  E-value: 1.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  18 IVLFLT-MLLRIFYIQAVG---VVHNVDVKDLANEQhnkngvLEANRGTIYDQTGKVLVQDSATYRV-----VVNLKGKD 88
Cdd:PRK15105  30 ILLALVfLLGRVAWLQVINpdmLVREGDMRSLRVQE------VSTSRGMITDRSGRPLAVSVPVKAIwadpkEVHDAGGI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  89 KVknsDETAQQLADVLEIDKEEV---IKNFHEGRtqveIGKIGRNLSRETKEKIRKLKIPGVSFMPEKARVYPNEDFASY 165
Cdd:PRK15105 104 SV---DDRWKALADALNIPLDQLsarINANPKGR----FIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAH 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 166 ILGFARPDDKGNTegkfGLEKSLDKYLRSTNGNIEYVGTRKGiPLTNDIGKVEpAKHGNNVYLTLDKQINSFLEEAMNKA 245
Cdd:PRK15105 177 LIGFTNVDSQGIE----GVEKSFDKWLTGQPGERIVRKDRYG-RVIEDISSTD-SQAAHNLALSIDERLQALVYRELNNA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 246 QQHYDPSMLIGIIANPKTGKVLAMSSKPSYNPNK---GDIEYFLNDPIANAYEPGSTMKVFTLAAAINEGVYNGKEYFQS 322
Cdd:PRK15105 251 VAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNlsgTPKDAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNT 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 323 GKYSVGSTDIKDHNggfGWGSITFDEGFERSSNVAFSILedQLLKP-NKFKQYMNKFGFNQKTGIDLPGESKNtLLLNTQ 401
Cdd:PRK15105 331 VPYRINGHEIKDVA---RYSELTLTGVLQKSSNVGVSKL--ALAMPsSALVDTYSRFGLGKATNLGLVGERSG-LYPQKQ 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 402 ----IQQVTTSFGQGSTVTPIQLIQAATAIANDGkMMQPYIVDKVVNPTNKQVIMenqPKEIgnpikketADKVRSLMER 477
Cdd:PRK15105 405 rwsdIERATFSFGYGLMVTPLQLARVYATIGSYG-IYRPLSITKVDPPVPGERVF---PESI--------VRTVVHMMES 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 478 VITSSKGtGTMYKVDGYPIGGKTGTAQIPNPEnGRYMegkENYIFSFLGMAPIDDPELIVYLAIKQPKlKGDEYGAQPLA 557
Cdd:PRK15105 473 VALPGGG-GVKAAIKGYRIAIKTGTAKKVGPD-GRYI---NKYIAYTAGVAPASQPRFALVVVINDPQ-AGKYYGGAVSA 546

                        570
                 ....*....|....*...
gi 446471523 558 EIFKPVIKNSLEYLKVKP 575
Cdd:PRK15105 547 PVFGAIMGGVLRTMNIEP 564
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 210-504 1.33e-38

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 152.00  E-value: 1.33e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 210 LTNDIGKVEPAKHGNNVYLTLDKQINSFLEEAMNKAQQHYDPSMLIG--IIANPKTGKVLAMSSKPSYNPNKgdieyfLN 287
Cdd:COG0744  281 LEELLGEDDLYRGGLKIYTTLDPKLQKAAEKAVKNVLPEGKPGGLQAalVVVDPKTGEVLAMVGGRDYGKSQ------FN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 288 DPIANAYEPGSTMKVFTLAAAINEG-----VYNGKEYfqsgKYSVGSTDIKDHNGGFgWGSITFDEGFERSSNVAFSILE 362
Cdd:COG0744  355 RATQAKRQPGSTFKPFVYAAALEQGytpatTVDDEPV----TFPGGGWSPKNYDGRY-RGPVTLREALANSLNTPAVRLA 429

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 363 DQLlKPNKFKQYMNKFGFNQKTGIDLpgesknTLLLNTqiqqvttsfgqgSTVTPIQLIQAATAIANDGKMMQPYIVDKV 442
Cdd:COG0744  430 QEV-GLDKVVDTARRLGITSPLDPNP------SLALGT------------SEVSPLEMASAYATFANGGVYVEPHAITKV 490

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446471523 443 VNPTNKqVIMENQPKEiGNPIKKETADKVRSLMERVITSskGTGTMYKVDGYPIGGKTGTAQ 504
Cdd:COG0744  491 TDADGK-VLYEAKPKC-EQVISPEVAYLMTDMLQDVVTS--GTGRAARLPGRPVAGKTGTTN 548
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 11-505 4.51e-30

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 126.04  E-value: 4.51e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  11 RYMMVAFIVLFLTMLLRIFYIQAVGVVHNVDVKDLANEQHNKNGVLEANRGTIYDQTGKVLVQDSATYRVVVNlkgKDKV 90
Cdd:PRK10795  20 RRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPLALNRTIYQLEMM---PEKV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  91 KNSDETAQQLADVLEIDKEEvIKNFHEGR------TQVEIgKIGRNLSRETKEKIRKLKIPGVSFMPEKARVYPNEDFAS 164
Cdd:PRK10795  97 DNLQQTLDALRSVVDLTDDD-IAAFRKERarsrrfTSIPV-KTNLTEVQVARFAVNQYRFPGVEVKGYQRRYYPYGSALT 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 165 YILGF---------ARPDDKG--------NTEGKFGLEKSLDKYLRSTNGNIEYVgtrkgiplTNDIGKV------EPAK 221
Cdd:PRK10795 175 HVIGYvskindkdvERLDKEGklanyaatHDIGKLGIERYYEDVLHGKTGYEEVE--------VNNRGRVirqlheQPPQ 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 222 HGNNVYLTLDKQINSFLEEAMNKaqqhydpSMLIGIIANPKTGKVLAMSSKPSYNPN-------KGDIEYFLNDP----- 289
Cdd:PRK10795 247 AGHDIYLTLDLKLQQYIETLLAG-------SRAAVVVTDPRTGGILALVSTPSYDPNlfvdgisSKDYSGLLNDPnrpli 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 290 ---IANAYEPGSTMKVFTLAAAINEGVYN-GKEYFQSGKYSV-GST----DIKDhnggFGWGSITFDEGFERSSN----- 355
Cdd:PRK10795 320 nraTQGVYPPASTVKPYVAVSALSAGVITrNTSLFDPGWWQLpGSEkryrDWKK----WGHGRLNVTKSLEESADtffyq 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 356 VAFSILEDQLlkpnkfKQYMNKFGFNQKTGIDLPGESKNTLLLNT-----------QIQQVTTSFGQGS-TVTPIQLIQA 423
Cdd:PRK10795 396 VAYDMGIDRL------SEWMGKFGYGHYTGIDLAEERSGNMPTREwkqkrfkkpwyQGDTIPVGIGQGYwTATPIQMSKA 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 424 ATAIANDGKMMQPYIVDKVVNPTNKQVIMENQPKEIGNpIKKETADKVRSLMERVITSSKGTGTMYKVDG-YPIGGKTGT 502
Cdd:PRK10795 470 LMTLINDGIVKVPHLLMSTAEDGKQVPWVQPHEPPVGD-IHSGYWEIAKDGMYGVANRPNGTAHKYFASApYKIAAKSGT 548


                 ...
gi 446471523 503 AQI 505
Cdd:PRK10795 549 AQV 551
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 55-197 2.43e-20

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 88.92  E-value: 2.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523   55 VLEANRGTIYDQTGKVLVQDSATYRVVVN---LKGKDKVKNSDETAQQLADVLEIDKEEVIKNFHEGR--TQVEIGKIGR 129
Cdd:pfam03717   1 PIPAPRGEIYDRNGVVLATNKPVYSLTITpskLKKADALKTALKLAKLLSNYEDLDDEDLTERFLKMNsyKSYYPVVIKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523  130 NLSRETKEKI--RKLKIPGVSFMPEKARVYPNEDFASYILGFARPDDKGNTE-------------GKFGLEKSLDKYLRS 194
Cdd:pfam03717  81 NLSEEEVARIeeNLLELPGVSIETDPVRYYPYGELAAHLLGYVGEITEEELEkyldkgysrgdlvGKSGLEKQYESVLRG 160


                  ...
gi 446471523  195 TNG 197
Cdd:pfam03717 161 KDG 163
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
256-502 7.12e-17

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 84.83  E-value: 7.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 256 GIIA-NPKTGKVLAMSSKPSYNPNKgdieyFlndpiaN----AY-EPGSTMKVFTLAAAINEG------VYNG-KEYFQS 322
Cdd:COG5009  424 ALVAlDPHTGAVLALVGGFDFEQSK-----F------NratqAKrQPGSSFKPFVYAAALDNGytpatiINDApIVFDDG 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 323 GKYSVGSTdiKDHNGGFgWGSITFDEGFERSSNVAfSIledQLLK---PNKFKQYMNKFGFNQKtgidLPgeskNTLlln 399
Cdd:COG5009  493 GGGGVWRP--KNYSGKF-YGPTTLREALEKSRNLV-TV---RLLQdvgIDYVIDYAERFGIYSK----LP----PNL--- 554

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 400 tqiqqvTTSFGQGStVTPIQLIQAATAIANDGKMMQPYIVDKVVNPTNKqVIMENQPKEIGNP----------------- 462
Cdd:COG5009  555 ------SLALGSGE-VTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGK-VIYRADPARACEDcdaaewdgaeprlpdpa 626

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446471523 463 ---IKKETADKVRSLMERVITSskGTGTMYKVDGYPIGGKTGT 502
Cdd:COG5009  627 eqvIDPRTAYQMTSMLRGVVQR--GTGRRARALGRDIAGKTGT 667
PASTA_Pbp2x-like_2 cd06575
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ...
 647-700 6.60e-16

PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119326 [Multi-domain]  Cd Length: 54  Bit Score: 72.10  E-value: 6.60e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446471523 647 KMPNIKGWSMRDVMYFSKLLKLDLKTSGTGYVTNQSIEKGKDLQEGDTLKLELE 700
Cdd:cd06575    1 TMPDLTGWSKRDALKLLELLGLKVKFSGSGYVVSQSIAPGTKVKKGTTITVTLK 54
PASTA_Pbp2x-like_1 cd06576
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ...
 591-644 6.35e-12

PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119327 [Multi-domain]  Cd Length: 55  Bit Score: 60.99  E-value: 6.35e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446471523 591 KVQSYVNQSMGTVEKSAEKEKLQPVILGEG-KIIKQYPQSGEVMSEGDRIFLLGN 644
Cdd:cd06576    1 KVPDVTGKSVEEAKKELKEAGLQPVVIGNGkKVKKQSPKPGEKVLEGSKVLLYTD 55
PASTA COG2815
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
588-697 6.52e-06

PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442064 [Multi-domain]  Cd Length: 220  Bit Score: 47.95  E-value: 6.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 588 SQLKVQSYVNQSMGTVEKSAEKEKLQPVILGE-------GKIIKQYPQSGEVMSEGDRIFLLGNN----AKMPNIKGWSM 656
Cdd:COG2815   23 EEVTVPDVVGMTVDEAEAALEEAGLKVEVEEEysddvpaGTVISQDPAAGTKVKKGSTVTLTVSKgpekVTVPDLVGKSL 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446471523 657 RDVMyfSKLLKLDLKTSGT----------GYVTNQSIEKGKDLQEGDTLKL 697
Cdd:COG2815  103 DEAE--AALEAAGLKVGEVeeeysddvpkGTVISQSPAAGTEVPKGTTVTL 151
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 647-699 1.31e-05

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 43.38  E-value: 1.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446471523  647 KMPNIKGWSMRDVMyfSKLLKLDLK---------TSGTGYVTNQSIEKGKDLQEGDTLKLEL 699
Cdd:pfam03793   2 TVPDVVGLSLEEAK--KLLEALGLKvgtveeysdDVGEGTVISQSPPAGTKVKKGSKVTLTV 61
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
588-697 3.19e-05

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 47.10  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 588 SQLKVQSYVNQSMGTVEKSAEKEKLQPVILGE--------GKIIKQYPQSGEVMSEGDRIFL---LGNNA-KMPNIKGWS 655
Cdd:NF033483 363 KEVTVPDVVGKTEAEAKEALEKAGLKVGKVEEeysddveeGKVISTDPEAGTRVKEGSTVTLvvsKGPEKvKVPDLTGKS 442

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446471523 656 MRDVMyfSKLLKLDLK----------TSGTGYVTNQSIEKGKDLQEGDTLKL 697
Cdd:NF033483 443 LDEAK--KALEDAGLKvgtieeeysdDVPKGTVISQDPAAGTEVDKGTTVTL 492
PASTA cd06573
PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins ...
 647-697 3.01e-04

PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119325 [Multi-domain]  Cd Length: 53  Bit Score: 39.23  E-value: 3.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446471523 647 KMPNIKGWSMRDVMYFSK-LLKLDlkTSGTGY-VTNQSIEKGKDLQEGDTLKL 697
Cdd:cd06573    1 EVPDLVGISKKDLEEQLYdLLKLD--ASGSGNkVVKQSPEAGTKVAEGSTIRI 51
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 591-641 9.32e-04

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 37.99  E-value: 9.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446471523  591 KVQSYVNQSMGTVEKSAEKEKLQPVI-------LGEGKIIKQYPQSGEVMSEGDRIFL 641
Cdd:pfam03793   2 TVPDVVGLSLEEAKKLLEALGLKVGTveeysddVGEGTVISQSPPAGTKVKKGSKVTL 59
PASTA COG2815
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
589-698 2.82e-03

PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442064 [Multi-domain]  Cd Length: 220  Bit Score: 39.86  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 589 QLKVQSYVNQSMGTVEKSAEKEKLQPVI--------LGEGKIIKQYPQSGEVMSEGDRIFLL----GNNAKMPNIKGWSM 656
Cdd:COG2815   91 KVTVPDLVGKSLDEAEAALEAAGLKVGEveeeysddVPKGTVISQSPAAGTEVPKGTTVTLVvskgPEPVTVPDLVGLTL 170

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446471523 657 RDVmyFSKLLKLDLK----------TSGTGYVTNQSIEKGKDLQEGDTLKLE 698
Cdd:COG2815  171 EEA--KAALEAAGLKvgvveeeysdDVPAGTVISQSPAAGTKVEKGSTVTLT 220
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
572-699 7.36e-03

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 39.39  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446471523 572 KVKPYTEKQIVDATKQsqLKVQSYVNqSMGTVEKSAEKEKlqpvilgeGKIIKQYPQSGEVMSEGDRIFL---LGNNA-K 647
Cdd:NF033483 434 KVPDLTGKSLDEAKKA--LEDAGLKV-GTIEEEYSDDVPK--------GTVISQDPAAGTEVDKGTTVTLtvsKGPEPvT 502

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446471523 648 MPNIKGWSMRDVMyfSKLLKLDLKTSGT----------GYVTNQSIEKGKDLQEGDTLKLEL 699
Cdd:NF033483 503 VPDVTGMSEEEAK--SALESAGLKVGVEeeevssdvpaGTVISQSPAAGTEVAKGSTVTLTV 562
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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