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Conserved domains on  [gi|446482965|ref|WP_000560819|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Salmonella]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10009472)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
7-113 3.98e-37

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


:

Pssm-ID: 444337  Cd Length: 105  Bit Score: 121.14  E-value: 3.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446482965   7 SDFRHVTPSGGNVFADLGFHKQDAEKfyadslneientLAIKQQLMEEITLWITQNQMKQAEVATVLHISRPRVSDVVNK 86
Cdd:COG5606    1 KEEIEIEESSGNVFADLGFPDEEAEE------------LKLKAQLMAAIRKLIKERGLTQAEAAELLGITQPRVSDLLRG 68

                         90       100
                 ....*....|....*....|....*..
gi 446482965  87 KCSKFTIDALVNMLSRIGKPVRVMVGP 113
Cdd:COG5606   69 KISKFSLDKLVNMLARLGQDVEIVVRP 95
 
Name Accession Description Interval E-value
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
7-113 3.98e-37

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 121.14  E-value: 3.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446482965   7 SDFRHVTPSGGNVFADLGFHKQDAEKfyadslneientLAIKQQLMEEITLWITQNQMKQAEVATVLHISRPRVSDVVNK 86
Cdd:COG5606    1 KEEIEIEESSGNVFADLGFPDEEAEE------------LKLKAQLMAAIRKLIKERGLTQAEAAELLGITQPRVSDLLRG 68

                         90       100
                 ....*....|....*....|....*..
gi 446482965  87 KCSKFTIDALVNMLSRIGKPVRVMVGP 113
Cdd:COG5606   69 KISKFSLDKLVNMLARLGQDVEIVVRP 95
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 19-112 1.10e-15

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 66.09  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446482965   19 VFADLGFhkQDAEKfyadslneientLAIKQQLMEEITLWITQNQMKQAEVATVLHISRPRVSDVVNKKCSKFTIDALVN 98
Cdd:pfam13744   1 VFADLGF--EDAEE------------LQAKAQLARAIARLIEGRGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDKLLD 66

                          90
                  ....*....|....
gi 446482965   99 MLSRIGKPVRVMVG 112
Cdd:pfam13744  67 FLTALGQDVEIVVK 80
 
Name Accession Description Interval E-value
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
7-113 3.98e-37

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 121.14  E-value: 3.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446482965   7 SDFRHVTPSGGNVFADLGFHKQDAEKfyadslneientLAIKQQLMEEITLWITQNQMKQAEVATVLHISRPRVSDVVNK 86
Cdd:COG5606    1 KEEIEIEESSGNVFADLGFPDEEAEE------------LKLKAQLMAAIRKLIKERGLTQAEAAELLGITQPRVSDLLRG 68

                         90       100
                 ....*....|....*....|....*..
gi 446482965  87 KCSKFTIDALVNMLSRIGKPVRVMVGP 113
Cdd:COG5606   69 KISKFSLDKLVNMLARLGQDVEIVVRP 95
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 19-112 1.10e-15

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 66.09  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446482965   19 VFADLGFhkQDAEKfyadslneientLAIKQQLMEEITLWITQNQMKQAEVATVLHISRPRVSDVVNKKCSKFTIDALVN 98
Cdd:pfam13744   1 VFADLGF--EDAEE------------LQAKAQLARAIARLIEGRGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDKLLD 66

                          90
                  ....*....|....
gi 446482965   99 MLSRIGKPVRVMVG 112
Cdd:pfam13744  67 FLTALGQDVEIVVK 80
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 64-105 7.52e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 32.86  E-value: 7.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446482965  64 MKQAEVATVLHISRPRVSDVVNKKcSKFTIDalvnMLSRIGK 105
Cdd:COG3093   23 LSQTELAKALGVSRQRISEILNGK-RAITAD----TALRLAR 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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