NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446492925|ref|WP_000570779|]
View 

MULTISPECIES: sensor histidine kinase [Bacillus]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
132-364 4.03e-56

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 184.05  E-value: 4.03e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 132 LVNIVPMFILMLLTP-FGMRNFNQKKMLKNQ-LNEANEQIKDLVKREERQRIARDLHDTLGHTLSLITLKSQLVEKLIVK 209
Cdd:COG4585    6 LLGALALLVGALLGLlLALVLLRARRAERAAeLERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 210 NPERASVEAKEITQTSRTALKQLRELISDMR-----MITVEEELEQ-IKAILQAANIELEIEQEASASSLSPIEQNILGM 283
Cdd:COG4585   86 DPEAAREELEEIRELAREALAELRRLVRGLRppaldDLGLAAALEElAERLLRAAGIRVELDVDGDPDRLPPEVELALYR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 284 CLREAVTNVVKHSKATQCTVSVLESQGELILKVEDNGIGL--EDQNNDGNGIRGMKERIALIDGFVELN-TIHSGTLLTV 360
Cdd:COG4585  166 IVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFdpEAAPGGGLGLRGMRERAEALGGTLTIGsAPGGGTRVRA 245


                 ....
gi 446492925 361 KVPV 364
Cdd:COG4585  246 TLPL 249
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
132-364 4.03e-56

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 184.05  E-value: 4.03e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 132 LVNIVPMFILMLLTP-FGMRNFNQKKMLKNQ-LNEANEQIKDLVKREERQRIARDLHDTLGHTLSLITLKSQLVEKLIVK 209
Cdd:COG4585    6 LLGALALLVGALLGLlLALVLLRARRAERAAeLERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 210 NPERASVEAKEITQTSRTALKQLRELISDMR-----MITVEEELEQ-IKAILQAANIELEIEQEASASSLSPIEQNILGM 283
Cdd:COG4585   86 DPEAAREELEEIRELAREALAELRRLVRGLRppaldDLGLAAALEElAERLLRAAGIRVELDVDGDPDRLPPEVELALYR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 284 CLREAVTNVVKHSKATQCTVSVLESQGELILKVEDNGIGL--EDQNNDGNGIRGMKERIALIDGFVELN-TIHSGTLLTV 360
Cdd:COG4585  166 IVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFdpEAAPGGGLGLRGMRERAEALGGTLTIGsAPGGGTRVRA 245


                 ....
gi 446492925 361 KVPV 364
Cdd:COG4585  246 TLPL 249
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
150-365 8.96e-24

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 102.36  E-value: 8.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 150 RNFNQKkmLKNQLNEANEQIKDLVKREE--RQRIARDLHDTLGHTLSLITLKSQLVEKLIVKNPERASVeAKEITQ---- 223
Cdd:PRK11644 274 RELNQS--LQKELARNRHLAERLLETEEsvRRDVARELHDEIGQTITAIRTQAGIIKRLAADNASVKQS-AQLIEQlslg 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 224 ---TSRTALKQLRELISDMrmITVEEELEQI--KAILQAANIELEIEQEASASSLSPIEQNILGMCLREAVTNVVKHSKA 298
Cdd:PRK11644 351 vydTVRRLLGRLRPRQLDD--LTLEQAIRSLmrEMELEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADA 428

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446492925 299 TQCTVSVLESQGELILKVEDNGIGL-EDQNNDGNGIRGMKERIALIDGFVELNTIHsGTLLTVKVPVV 365
Cdd:PRK11644 429 SAVTLQGWQQDERLMLVIEDDGSGLpPGSGQQGFGLRGMRERVTALGGTLTISCTH-GTRLSVSLPQR 495
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 177-240 1.38e-21

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 87.29  E-value: 1.38e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446492925  177 ERQRIARDLHDTLGHTLSLITLKSQLVEKLIVKNPERASVEAKEITQTSRTALKQLRELISDMR 240
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDPEEAREQLDAIRELAREALQELRRLLGDLR 64
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 281-363 5.51e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 86.07  E-value: 5.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 281 LGMCLREAVTNVVKHSKATQCTVSVLESQGELILKVEDNGIGLEDQNND---GNGIRGMKERIALIDGFVELN-TIHSGT 356
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPgggGFGLLGMRERAELLGGTLTIGsRPGGGT 80


                 ....*..
gi 446492925 357 LLTVKVP 363
Cdd:cd16917   81 RVTARLP 87
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 285-364 2.12e-04

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 40.32  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925   285 LREAVTNVVKHSKATQC-TVSVLESQGELILKVEDNGIGLE--------------DQNNDGNGIRGM-----KERIALID 344
Cdd:smart00387  10 LSNLLDNAIKYTPEGGRiTVTLERDGDHVEITVEDNGPGIPpedlekifepffrtDKRSRKIGGTGLglsivKKLVELHG 89

                           90       100
                   ....*....|....*....|.
gi 446492925   345 GFVEL-NTIHSGTLLTVKVPV 364
Cdd:smart00387  90 GEISVeSEPGGGTTFTITLPL 110
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
132-364 4.03e-56

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 184.05  E-value: 4.03e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 132 LVNIVPMFILMLLTP-FGMRNFNQKKMLKNQ-LNEANEQIKDLVKREERQRIARDLHDTLGHTLSLITLKSQLVEKLIVK 209
Cdd:COG4585    6 LLGALALLVGALLGLlLALVLLRARRAERAAeLERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 210 NPERASVEAKEITQTSRTALKQLRELISDMR-----MITVEEELEQ-IKAILQAANIELEIEQEASASSLSPIEQNILGM 283
Cdd:COG4585   86 DPEAAREELEEIRELAREALAELRRLVRGLRppaldDLGLAAALEElAERLLRAAGIRVELDVDGDPDRLPPEVELALYR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 284 CLREAVTNVVKHSKATQCTVSVLESQGELILKVEDNGIGL--EDQNNDGNGIRGMKERIALIDGFVELN-TIHSGTLLTV 360
Cdd:COG4585  166 IVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFdpEAAPGGGLGLRGMRERAEALGGTLTIGsAPGGGTRVRA 245


                 ....
gi 446492925 361 KVPV 364
Cdd:COG4585  246 TLPL 249
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
150-365 8.96e-24

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 102.36  E-value: 8.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 150 RNFNQKkmLKNQLNEANEQIKDLVKREE--RQRIARDLHDTLGHTLSLITLKSQLVEKLIVKNPERASVeAKEITQ---- 223
Cdd:PRK11644 274 RELNQS--LQKELARNRHLAERLLETEEsvRRDVARELHDEIGQTITAIRTQAGIIKRLAADNASVKQS-AQLIEQlslg 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 224 ---TSRTALKQLRELISDMrmITVEEELEQI--KAILQAANIELEIEQEASASSLSPIEQNILGMCLREAVTNVVKHSKA 298
Cdd:PRK11644 351 vydTVRRLLGRLRPRQLDD--LTLEQAIRSLmrEMELEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADA 428

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446492925 299 TQCTVSVLESQGELILKVEDNGIGL-EDQNNDGNGIRGMKERIALIDGFVELNTIHsGTLLTVKVPVV 365
Cdd:PRK11644 429 SAVTLQGWQQDERLMLVIEDDGSGLpPGSGQQGFGLRGMRERVTALGGTLTISCTH-GTRLSVSLPQR 495
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 150-368 1.86e-23

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 101.24  E-value: 1.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 150 RNFNQKkmLKNQLNEANEQIKDLVKREERQR--IARDLHDTLGHTLSLITLKSQLVEKLivkNPERASVE-AKEITQTSR 226
Cdd:COG3851  265 RQLNQQ--LEQELRENRALARQLVSAEESERreIARELHDEIGQNITAIRTQASILKRL---APQPEIEQsAQSIESLAL 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 227 TALKQLRELISDMRMITVEE-ELEQ------IKAILQAANIELEIEQEASASSLSPIEQNILGMCLREAVTNVVKHSKAT 299
Cdd:COG3851  340 RIYDTTRRLLDRLRPAVLDElGLEEalrelpRELAFEEPGISCQLDLRGDPSLLDDTLQLTLYRLVQEALTNILKHAEAS 419

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 300 QCTVSVLESQGELILKVEDNGIGL-EDQNNDGNGIRGMKERIALIDGFVELNTIHSGTLLTVKVPVVIRT 368
Cdd:COG3851  420 QIRISLSQDKRLLSLEIRDDGIGLpPELRAKGFGLRGMRERVRALGGDFRLSSAPKGTRLSVLLPTPAAS 489
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 177-240 1.38e-21

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 87.29  E-value: 1.38e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446492925  177 ERQRIARDLHDTLGHTLSLITLKSQLVEKLIVKNPERASVEAKEITQTSRTALKQLRELISDMR 240
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDPEEAREQLDAIRELAREALQELRRLLGDLR 64
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 281-363 5.51e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 86.07  E-value: 5.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 281 LGMCLREAVTNVVKHSKATQCTVSVLESQGELILKVEDNGIGLEDQNND---GNGIRGMKERIALIDGFVELN-TIHSGT 356
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPgggGFGLLGMRERAELLGGTLTIGsRPGGGT 80


                 ....*..
gi 446492925 357 LLTVKVP 363
Cdd:cd16917   81 RVTARLP 87
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
149-363 9.13e-21

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 93.76  E-value: 9.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 149 MRNFNQkkMLKNQL--NEANEQIKDLVKREERQRIARDLHDTLGHTLSLITLKSQLVEKLIVKNPERASVEAKEITQTSR 226
Cdd:PRK10935 335 MNNVAQ--MLGRGLyfNQAQKQQQQLLLMEERATIARELHDSLAQVLSYLKIQLTLLKRSLDEDNAKAQSIIAEFDQALS 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 227 TALKQLRELISDMRMiTVEE-----ELEQIKAILQA-ANIELEIEQEASASSLSPIEQ-NILGMcLREAVTNVVKHSKAT 299
Cdd:PRK10935 413 DAYRQLRELLTTFRL-TIQEanlgsALEEMLDQLRNqTDAKITLDCRLPSQALDAQQQvHLLQI-IREATLNAIKHANAS 490

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446492925 300 QCTVS-VLESQGELILKVEDNGIGLEDQNN-DGN-GIRGMKERIALIDGFVEL-NTIHSGTLLTVKVP 363
Cdd:PRK10935 491 EIAVScVTNPDGEHTVSIRDDGIGIGELKEpEGHyGLNIMQERAERLGGTLTIsQPPGGGTTVSLTFP 558
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
176-339 8.94e-15

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 75.48  E-value: 8.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 176 EERQRIARDLHDTLGHTLSliTLKSQlVEKLIVKN---PERASVEAKEITQTSRTALKQLRELISDMRMITVEEELeqiK 252
Cdd:PRK10600 360 EERATIARELHDSIAQSLS--CMKMQ-VSCLQMQGdalPESSRELLSQIRNELNASWRQLRELLTTFRLQLTEPGL---R 433

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 253 AILQAANieleieQEASASSLSPIE-------------QNI-LGMCLREAVTNVVKHSKATQCTVSVLESQGELILKVED 318
Cdd:PRK10600 434 PALEASC------EEFSARFGFPVKldyqlpprlvpshQAIhLLQIAREALSNALKHAQASEVVVTVAQNQNQVKLSVQD 507

                        170       180
                 ....*....|....*....|...
gi 446492925 319 NGIGLEDQNNDGN--GIRGMKER 339
Cdd:PRK10600 508 NGCGVPENAERSNhyGLIIMRDR 530
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
161-326 1.09e-07

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 52.22  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 161 QLNEANEQIKDLvkREERQRIARDL-HDtLGHTLSLITLKSQLVEKLIVKNPErasvEAKEITQTSRTALKQLRELISDM 239
Cdd:COG2205    1 ELEEALEELEEL--ERLKSEFLANVsHE-LRTPLTSILGAAELLLDEEDLSPE----ERRELLEIIRESAERLLRLIEDL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 240 RMIT-------------------VEEELEQIKAILQAANIELEIEQEASASSLSpIEQNILGMCLREAVTNVVKHSKATQ 300
Cdd:COG2205   74 LDLSrlesgklslelepvdlaelLEEAVEELRPLAEEKGIRLELDLPPELPLVY-ADPELLEQVLANLLDNAIKYSPPGG 152

                        170       180
                 ....*....|....*....|....*..
gi 446492925 301 C-TVSVLESQGELILKVEDNGIGLEDQ 326
Cdd:COG2205  153 TiTISARREGDGVRISVSDNGPGIPEE 179
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
242-364 4.72e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 48.37  E-value: 4.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 242 ITVEEELEQIKAILQAanieleIEQEASASSLSPIEQNILGMCLREAVTNVVKHS----KATQCTVSVLESQGELILKVE 317
Cdd:COG2172    2 LSLPADLEDLGLARRA------VRALLRELGLDEDDADDLVLAVSEAVTNAVRHAyggdPDGPVEVELELDPDGLEIEVR 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446492925 318 DNGIGLeDQNNDGNGIRGMKER---IALIDGF---VELNTIHSGTLLTVKVPV 364
Cdd:COG2172   76 DEGPGF-DPEDLPDPYSTLAEGgrgLFLIRRLmdeVEYESDPGGTTVRLVKRL 127
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
67-326 2.24e-06

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 49.14  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925  67 AFIQMILTFLFAIFYNPFMIFFGFFTASAMGFAPSKKVFRVLLCLLVVMLGAFVFVNMNQLTPANLVNIVPMFILMLLTP 146
Cdd:COG0642    8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 147 FGMRNFNQKKMLKNQLNEANEQIKDLVkreerQRIArdlHDtLGHTLSLITLKSQLVEklivknpERASVEAKEITQTSR 226
Cdd:COG0642   88 LLLLLLLLLLALLLLLEEANEAKSRFL-----ANVS---HE-LRTPLTAIRGYLELLL-------EELDEEQREYLETIL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 227 TALKQLRELISDMRMIT-------------------VEEELEQIKAILQAANIELEIEQEASASSLSpIEQNILGMCLRE 287
Cdd:COG0642  152 RSADRLLRLINDLLDLSrleagklelepepvdlaelLEEVVELFRPLAEEKGIELELDLPDDLPTVR-GDPDRLRQVLLN 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446492925 288 AVTNVVKHSKA-TQCTVSVLESQGELILKVEDNGIGLEDQ 326
Cdd:COG0642  231 LLSNAIKYTPEgGTVTVSVRREGDRVRISVEDTGPGIPPE 270
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 281-366 6.21e-06

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 44.67  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925  281 LGMCLREAVTNVVKHS-KATQCTVSVlESQGELILKVEDNGIGLEDQNND-----------------GNGIRGMKERIAL 342
Cdd:pfam02518   6 LRQVLSNLLDNALKHAaKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPrifepfstadkrggggtGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|....*
gi 446492925  343 IDGFVEL-NTIHSGTLLTVKVPVVI 366
Cdd:pfam02518  85 LGGTITVeSEPGGGTTVTLTLPLAQ 109
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
19-326 1.07e-04

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 43.77  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925  19 MWLVYLLFPIYNLTQVSGWKLVMGIGMLIVFIITYRQLYFVQKTFVLWAFIQMILTFLFAIFYNPFMIFFGFFTASAMGF 98
Cdd:COG5002    2 LLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925  99 APSKKVFRVLLCLLVVMLGAFVFVNMNQLTPANLVNIVPMFILMLLTPFGMRNFNQKKMLKNQLNEANEQIKDLVKREER 178
Cdd:COG5002   82 ALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 179 QRIARDLHDTLGH---T-LSLITLKSQLVEKLIVKNPErasvEAKEITQTSRTALKQLRELISDMRMIT----------- 243
Cdd:COG5002  162 EQMRREFVANVSHelrTpLTSIRGYLELLLDGAADDPE----ERREYLEIILEEAERLSRLVNDLLDLSrlesgelklek 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 244 --------VEEELEQIKAILQAANIELEIEQEASASSLSpIEQNILGMCLREAVTNVVKHSKA-TQCTVSVLESQGELIL 314
Cdd:COG5002  238 epvdlaelLEEVVEELRPLAEEKGIELELDLPEDPLLVL-GDPDRLEQVLTNLLDNAIKYTPEgGTITVSLREEDDQVRI 316

                        330
                 ....*....|..
gi 446492925 315 KVEDNGIGLEDQ 326
Cdd:COG5002  317 SVRDTGIGIPEE 328
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 285-364 2.12e-04

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 40.32  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925   285 LREAVTNVVKHSKATQC-TVSVLESQGELILKVEDNGIGLE--------------DQNNDGNGIRGM-----KERIALID 344
Cdd:smart00387  10 LSNLLDNAIKYTPEGGRiTVTLERDGDHVEITVEDNGPGIPpedlekifepffrtDKRSRKIGGTGLglsivKKLVELHG 89

                           90       100
                   ....*....|....*....|.
gi 446492925   345 GFVEL-NTIHSGTLLTVKVPV 364
Cdd:smart00387  90 GEISVeSEPGGGTTFTITLPL 110
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 244-364 3.22e-04

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 42.58  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 244 VEEELEQIKAILQAANIELEIEqeASASSLsPIEQNI-LGMCLREAVTNVVKHS-KATQC---TVSVLESQGELILKVED 318
Cdd:COG3920  365 LRELLEPLRDSYGGRGIRIELD--GPDVEL-PADAAVpLGLILNELVTNALKHAfLSGEGgriRVSWRREDGRLRLTVSD 441

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446492925 319 NGIGL----EDQNNDGNGIRGMKERIALIDGFVELNTiHSGTLLTVKVPV 364
Cdd:COG3920  442 NGVGLpedvDPPARKGLGLRLIRALVRQLGGTLELDR-PEGTRVRITFPL 490
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 200-326 2.75e-03

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 39.77  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 200 SQLVEKlivKNPERASVEAKEITQTSRTALKQLRELISDM----RMITVEEELEQI-------------KAILQAANIEL 262
Cdd:COG4251  304 SQLLEE---DYGDKLDEEGREYLERIRDAAERMQALIDDLlaysRVGRQELEFEPVdlnelleevledlEPRIEERGAEI 380

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446492925 263 EIEQ----EASASSLSPIEQNILGmclreavtNVVKHSKATQC---TVSVLESQGELILKVEDNGIGLEDQ 326
Cdd:COG4251  381 EVGPlptvRGDPTLLRQVFQNLIS--------NAIKYSRPGEPpriEIGAEREGGEWVFSVRDNGIGIDPE 443
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
157-345 6.25e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 38.46  E-value: 6.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 157 MLKNQLNEANEQIKDLVKREERQRIARdlhdtlgHTLSLITLKSQ------------LVEKLIVKNPERASVEAKEITQT 224
Cdd:COG2972  213 ILARSFNEMVERIKELIEEVYELELEK-------KEAELKALQAQinphflfntlnsIRWLAELEDPEEAEEMLEALSKL 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492925 225 SRTALKQLRElisdmrMITVEEELEQIKAILQA------ANIELEIEQEASasslsPIEQNILGMCLREAVTNVVKH--- 295
Cdd:COG2972  286 LRYSLSKGDE------LVTLEEELELIKSYLEIqklrfgDRLEVEIEIDEE-----LLDLLIPKLILQPLVENAIEHgie 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446492925 296 SKATQCT--VSVLESQGELILKVEDNGIGLEDQ-------------NNDGNGIRGMKERIALIDG 345
Cdd:COG2972  355 PKEGGGTirISIRKEGDRLVITVEDNGVGMPEEkleklleelsskgEGRGIGLRNVRERLKLYYG 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH