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Conserved domains on  [gi|446493140|ref|WP_000570994|]
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MULTISPECIES: GNAT family N-acetyltransferase [Bacillus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514829)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|10940244|9175471
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 3.37e-45

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


:

Pssm-ID: 436212  Cd Length: 123  Bit Score: 148.97  E-value: 3.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  157 IIKIDEYAFGTNRKEFLKKRIMQSEQCIVVKDKEQNVLGYGLSIQTPENKIIGPVVAKNDEMAMRIVHDLAKGHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 446493140  237 DVLEGKKDFMKVLEIAGFKKVNTPPIMMKNSDQLLKRNNELYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 9-123 1.62e-14

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 68.87  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   9 ERLRKEQISDIVALSSYIGWDYNREEIETIFnagivygVWNEKEELIASAAIILYGEKLASIGMVIVHPDYKGRGIGKII 88
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYALEEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRL 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446493140  89 TEACVKSVSAH--TPIMLIATDEGKPLYEKLGFRAVS 123
Cdd:COG1246   74 LEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 3.37e-45

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 148.97  E-value: 3.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  157 IIKIDEYAFGTNRKEFLKKRIMQSEQCIVVKDKEQNVLGYGLSIQTPENKIIGPVVAKNDEMAMRIVHDLAKGHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 446493140  237 DVLEGKKDFMKVLEIAGFKKVNTPPIMMKNSDQLLKRNNELYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 9-123 1.62e-14

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 68.87  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   9 ERLRKEQISDIVALSSYIGWDYNREEIETIFnagivygVWNEKEELIASAAIILYGEKLASIGMVIVHPDYKGRGIGKII 88
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYALEEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRL 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446493140  89 TEACVKSVSAH--TPIMLIATDEGKPLYEKLGFRAVS 123
Cdd:COG1246   74 LEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 29-123 1.93e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 54.58  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   29 DYNREEIETiFNAGIVYGVWneKEELIASAAIIL---YGEKLAS---------IGMVIVHPDYKGRGIGKIITEACVKSV 96
Cdd:pfam13673   4 DYSEEGIET-FYEFISPEAL--RERIDQGEYFFFvafEGGQIVGvialrdrghISLLFVDPDYQGQGIGKALLEAVEDYA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 446493140   97 SAHTP----IMLIATDEGKPLYEKLGFRAVS 123
Cdd:pfam13673  81 EKDGIklseLTVNASPYAVPFYEKLGFRATG 111
PRK07757 PRK07757
N-acetyltransferase;
10-123 3.68e-09

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 54.43  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  10 RLRKEQISDIVALSSYIGwDYNREEI----------ETIFNagivYGVWNEKEELIASAAIILYGEKLASIGMVIVHPDY 79
Cdd:PRK07757   3 EIRKARLSDVKAIHALIN-VYAKKGLmlprsldelyENIRD----FYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDY 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446493140  80 KGRGIGKIITEACVKsvsahtpimlIATDEG----------KPLYEKLGFRAVS 123
Cdd:PRK07757  78 RGQGIGRMLVEACLE----------EARELGvkrvfaltyqPEFFEKLGFREVD 121
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-94 6.06e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.26  E-value: 6.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446493140  47 VWNEKEELIASAAIILYG--EKLASIGMVIVHPDYKGRGIGKIITEACVK 94
Cdd:cd04301    3 VAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 3.37e-45

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 148.97  E-value: 3.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  157 IIKIDEYAFGTNRKEFLKKRIMQSEQCIVVKDKEQNVLGYGLSIQTPENKIIGPVVAKNDEMAMRIVHDLAKGHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 446493140  237 DVLEGKKDFMKVLEIAGFKKVNTPPIMMKNSDQLLKRNNELYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 9-123 1.62e-14

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 68.87  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   9 ERLRKEQISDIVALSSYIGWDYNREEIETIFnagivygVWNEKEELIASAAIILYGEKLASIGMVIVHPDYKGRGIGKII 88
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYALEEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRL 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446493140  89 TEACVKSVSAH--TPIMLIATDEGKPLYEKLGFRAVS 123
Cdd:COG1246   74 LEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
53-122 2.08e-11

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 58.77  E-value: 2.08e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446493140  53 ELIASAAIILYGEKLASIGMVIVHPDYKGRGIGKIITEACVKSVSAHTPIMLI-----ATDEGKPLYEKLGFRAV 122
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFlyvdaDNPAARRLYERLGFRPV 75
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
11-123 2.94e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 60.10  E-value: 2.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  11 LRKEQISDIVALSSYI--GWDYNREE--IETIFNAGIVYGVW--NEKEELIASAAI----ILYGEKLASIGMVIVHPDYK 80
Cdd:COG3153    1 IRPATPEDAEAIAALLraAFGPGREAelVDRLREDPAAGLSLvaEDDGEIVGHVALspvdIDGEGPALLLGPLAVDPEYR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446493140  81 GRGIGKIITEACVKSVSA--HTPIMLIATDEGKPLYEKLGFRAVS 123
Cdd:COG3153   81 GQGIGRALMRAALEAARErgARAVVLLGDPSLLPFYERFGFRPAG 125
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
50-123 1.71e-10

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 57.89  E-value: 1.71e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446493140  50 EKEELIASAAIILYGEKLASIGMVIVHPDYKGRGIGKIITEACVKSVSAH--TPIMLIATDEGKPLYEKLGFRAVS 123
Cdd:COG2153   41 DDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERgaRRIVLSAQAHAVGFYEKLGFVPVG 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 29-123 1.93e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 54.58  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   29 DYNREEIETiFNAGIVYGVWneKEELIASAAIIL---YGEKLAS---------IGMVIVHPDYKGRGIGKIITEACVKSV 96
Cdd:pfam13673   4 DYSEEGIET-FYEFISPEAL--RERIDQGEYFFFvafEGGQIVGvialrdrghISLLFVDPDYQGQGIGKALLEAVEDYA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 446493140   97 SAHTP----IMLIATDEGKPLYEKLGFRAVS 123
Cdd:pfam13673  81 EKDGIklseLTVNASPYAVPFYEKLGFRATG 111
PRK07757 PRK07757
N-acetyltransferase;
10-123 3.68e-09

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 54.43  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  10 RLRKEQISDIVALSSYIGwDYNREEI----------ETIFNagivYGVWNEKEELIASAAIILYGEKLASIGMVIVHPDY 79
Cdd:PRK07757   3 EIRKARLSDVKAIHALIN-VYAKKGLmlprsldelyENIRD----FYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDY 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446493140  80 KGRGIGKIITEACVKsvsahtpimlIATDEG----------KPLYEKLGFRAVS 123
Cdd:PRK07757  78 RGQGIGRMLVEACLE----------EARELGvkrvfaltyqPEFFEKLGFREVD 121
Eis COG4552
Predicted acetyltransferase [General function prediction only];
6-119 3.76e-08

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 53.75  E-value: 3.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   6 FRVERLRKEQISDIVALSSYI-GWDYNREEIET---IFNAGIVYGVWNEkEELIASAAII-----LYGEKL--ASIGMVI 74
Cdd:COG4552    1 MEIRPLTEDDLDAFARLLAYAfGPEPDDEELEAyrpLLEPGRVLGVFDD-GELVGTLALYpftlnVGGARVpmAGITGVA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446493140  75 VHPDYKGRGIGK-IITEACVKSVSAHTPI-MLIATDEgkPLYEKLGF 119
Cdd:COG4552   80 VAPEHRRRGVARaLLREALAELRERGQPLsALYPFEP--GFYRRFGY 124
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-128 6.52e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 49.27  E-value: 6.52e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446493140  58 AAIILYGEKLASIGMVIVHPDYKGRGIGKIITEACVKSVSAH--TPIMLIATDEGKP---LYEKLGFRAVSYVSKY 128
Cdd:COG0456    4 LLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERgaRRLRLEVREDNEAaiaLYEKLGFEEVGERPNY 79
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 10-123 1.16e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 49.67  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  10 RLRKEQISDIVALSSYIGWDYNREEIETIFNAGIVYGVwNEKEELIASAAIILYGEKLASIGMVIVHPDYKGRGIGKIIT 89
Cdd:COG0454    2 SIRKATPEDINFILLIEALDAELKAMEGSLAGAEFIAV-DDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446493140  90 EAC--------VKSVSAHTpimLIATDEGKPLYEKLGFRAVS 123
Cdd:COG0454   81 EALlewarergCTALELDT---LDGNPAAIRFYERLGFKEIE 119
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 47-120 1.52e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 45.14  E-value: 1.52e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446493140   47 VWNEKEELIASAAIILYGEKLASIG-MVIVHPDYKGRGIGKIITEACVKSVSAH--TPIMLIATDEGKPLYEKLGFR 120
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGgiKLLELETTNRAAAFYEKLGFE 83
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 32-119 2.72e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 45.59  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   32 REEIETIFNAGIVYGVWNEKEELIASAAIILYGE--KLASIGMVIVHPDYKGRGIGKIITEACVKSVSAH--TPIMLIAT 107
Cdd:pfam00583  22 DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERgcERIFLEVA 101

                          90
                  ....*....|....*
gi 446493140  108 DEGKP---LYEKLGF 119
Cdd:pfam00583 102 ADNLAaiaLYEKLGF 116
PTZ00330 PTZ00330
acetyltransferase; Provisional
 64-121 1.06e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 44.45  E-value: 1.06e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140  64 GEKLASIGMVIVHPDYKGRGIGK-IITEACVKSVSAHT-PIMLIATDEGKPLYEKLGFRA 121
Cdd:PTZ00330  79 GKCVGHIEDVVVDPSYRGQGLGRaLISDLCEIARSSGCyKVILDCTEDMVAFYKKLGFRA 138
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 10-120 6.03e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 41.79  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493140   10 RLRKEQISDIVALSSYI-GWDY---NREEIETIFNAGIVYGVWNEkEELIASAAII-----LYGEKL--ASIGMVIVHPD 78
Cdd:pfam13527   3 PLTEDEFDEVLRLLEYAfQDEDspeLREYFRPLLEEGRVLGAFDD-GELVSTLALYpfelnVPGKTLpaAGITGVATYPE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 446493140   79 YKGRGI-GKIITEACVKSVSAHTPI-MLIATDEgkPLYEKLGFR 120
Cdd:pfam13527  82 YRGRGVmSRLLRRSLEEMRERGVPLsFLYPSSY--PIYRRFGYE 123
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 52-121 5.95e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 38.08  E-value: 5.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446493140   52 EELIASAAIIL---YGEklasIGMVIVHPDYKGRGIGKIITEACVKSVSA--HTPIMLIATDEgKP---LYEKLGFRA 121
Cdd:pfam08445   7 GDTGELAAWCLrlpGGE----LGALQTLPEHRRRGLGSRLVAALARGIAErgITPFAVVVAGN-TPsrrLYEKLGFRK 79
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-94 6.06e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.26  E-value: 6.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446493140  47 VWNEKEELIASAAIILYG--EKLASIGMVIVHPDYKGRGIGKIITEACVK 94
Cdd:cd04301    3 VAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
PRK09831 PRK09831
GNAT family N-acetyltransferase;
70-122 9.80e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 38.79  E-value: 9.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446493140  70 IGMVIVHPDYKGRGIGKIITEACVKSVSAHTpimLIATDEGKPLYEKLGFRAV 122
Cdd:PRK09831  75 IDMLFVDPEYTRRGVASALLKPLIKSESELT---VDASITAKPFFERYGFQTV 124
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
73-122 4.97e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 36.90  E-value: 4.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446493140  73 VIVHPDYKGRGIGKIITEACVKSVSA---HTpIMLIATDEGKP---LYEKLGFRAV 122
Cdd:COG1247   86 IYVDPDARGRGIGRALLEALIERARArgyRR-LVAVVLADNEAsiaLYEKLGFEEV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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