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Conserved domains on  [gi|446493151|ref|WP_000571005|]
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MULTISPECIES: GNAT family N-acetyltransferase [Bacillus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514829)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|10940244|9175471
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 6.45e-46

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


:

Pssm-ID: 436212  Cd Length: 123  Bit Score: 150.52  E-value: 6.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151  157 IIKIDEYAFGTNRKEFLKKRMMQSEQCTVVKDKEQNILGYGLSIQTPENKILGPVVAKNDEMAINIVHYLAKGHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 446493151  237 DVPEVKKDFVKELEVTGFKKVNTPPIMMKNSDQFLKRNGELYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 6-123 2.94e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 65.40  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   6 IRVDRLREEEIGDIVALSSYigWDYsREEIETIFnagivygVWNERKKLIASAAIILYGEKVASIGMVIVHPDYKGRGIG 85
Cdd:COG1246    1 MTIRPATPDDVPAILELIRP--YAL-EEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIG 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446493151  86 KAITHSCMNSVSAR--TPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:COG1246   71 RRLLEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 6.45e-46

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 150.52  E-value: 6.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151  157 IIKIDEYAFGTNRKEFLKKRMMQSEQCTVVKDKEQNILGYGLSIQTPENKILGPVVAKNDEMAINIVHYLAKGHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 446493151  237 DVPEVKKDFVKELEVTGFKKVNTPPIMMKNSDQFLKRNGELYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 6-123 2.94e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 65.40  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   6 IRVDRLREEEIGDIVALSSYigWDYsREEIETIFnagivygVWNERKKLIASAAIILYGEKVASIGMVIVHPDYKGRGIG 85
Cdd:COG1246    1 MTIRPATPDDVPAILELIRP--YAL-EEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIG 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446493151  86 KAITHSCMNSVSAR--TPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:COG1246   71 RRLLEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 29-123 5.04e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 50.73  E-value: 5.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   29 DYSREEIETiFNAGIVYGVWNERkklIASAAIILY----GEKVAS---------IGMVIVHPDYKGRGIGKAITH----S 91
Cdd:pfam13673   4 DYSEEGIET-FYEFISPEALRER---IDQGEYFFFvafeGGQIVGvialrdrghISLLFVDPDYQGQGIGKALLEavedY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 446493151   92 CMNSVSARTPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:pfam13673  80 AEKDGIKLSELTVNASPYAVPFYEKLGFRATG 111
PTZ00330 PTZ00330
acetyltransferase; Provisional
 3-120 7.29e-08

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 50.61  E-value: 7.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   3 ELEIRVdrLREEEIGDIVALSSYI--GWDYSREEIETIFN----AGIVYGVWNER--KKLIASAAIILY------GEKVA 68
Cdd:PTZ00330   6 SLELRD--LEEGDLGSVLELLSHLtsAPALSQEELEQIAArrrlAGVVTRVFVHSptQRIVGTASLFVEpkftrgGKCVG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446493151  69 SIGMVIVHPDYKGRGIGKAITHSCMNSVSART--PIMLIATDEGKYLYEKLGFR 120
Cdd:PTZ00330  84 HIEDVVVDPSYRGQGLGRALISDLCEIARSSGcyKVILDCTEDMVAFYKKLGFR 137
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-88 1.07e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.87  E-value: 1.07e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446493151  53 KLIASAAIILYG--EKVASIGMVIVHPDYKGRGIGKAI 88
Cdd:cd04301    9 EIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSAL 46
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 6.45e-46

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 150.52  E-value: 6.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151  157 IIKIDEYAFGTNRKEFLKKRMMQSEQCTVVKDKEQNILGYGLSIQTPENKILGPVVAKNDEMAINIVHYLAKGHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 446493151  237 DVPEVKKDFVKELEVTGFKKVNTPPIMMKNSDQFLKRNGELYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 6-123 2.94e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 65.40  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   6 IRVDRLREEEIGDIVALSSYigWDYsREEIETIFnagivygVWNERKKLIASAAIILYGEKVASIGMVIVHPDYKGRGIG 85
Cdd:COG1246    1 MTIRPATPDDVPAILELIRP--YAL-EEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIG 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446493151  86 KAITHSCMNSVSAR--TPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:COG1246   71 RRLLEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
53-122 4.36e-12

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 60.69  E-value: 4.36e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446493151  53 KLIASAAIILYGEKVASIGMVIVHPDYKGRGIGKAITHSCMNSVSARTPIMLI-----ATDEGKYLYEKLGFRVV 122
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFlyvdaDNPAARRLYERLGFRPV 75
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
6-123 2.14e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.79  E-value: 2.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   6 IRvdRLREEEIGDIVAL--SSYIGWDYSR--EEIETIFNAGIVYgVWNERKKLIASAAI----ILYGEKVASIGMVIVHP 77
Cdd:COG3153    1 IR--PATPEDAEAIAALlrAAFGPGREAElvDRLREDPAAGLSL-VAEDDGEIVGHVALspvdIDGEGPALLLGPLAVDP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446493151  78 DYKGRGIGKAITHSCMNSVSAR--TPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:COG3153   78 EYRGQGIGRALMRAALEAARERgaRAVVLLGDPSLLPFYERFGFRPAG 125
Eis COG4552
Predicted acetyltransferase [General function prediction only];
4-128 9.27e-10

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 58.76  E-value: 9.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   4 LEIRvdRLREEEIGDIVALSSYI-GWDYSREEIET---IFNAGIVYGVWnERKKLIASAAII-----LYGEKV--ASIGM 72
Cdd:COG4552    1 MEIR--PLTEDDLDAFARLLAYAfGPEPDDEELEAyrpLLEPGRVLGVF-DDGELVGTLALYpftlnVGGARVpmAGITG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446493151  73 VIVHPDYKGRGIGKA-ITHSCMNSVSARTPI-MLIATDEGkyLYEKLGFRVVSYVSKY 128
Cdd:COG4552   78 VAVAPEHRRRGVARAlLREALAELRERGQPLsALYPFEPG--FYRRFGYELAGDRRRY 133
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
53-123 4.37e-09

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 53.65  E-value: 4.37e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446493151  53 KLIASAAIILYGEKVASIGMVIVHPDYKGRGIGKAITHSCMNSVSAR--TPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:COG2153   44 ELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERgaRRIVLSAQAHAVGFYEKLGFVPVG 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 29-123 5.04e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 50.73  E-value: 5.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   29 DYSREEIETiFNAGIVYGVWNERkklIASAAIILY----GEKVAS---------IGMVIVHPDYKGRGIGKAITH----S 91
Cdd:pfam13673   4 DYSEEGIET-FYEFISPEALRER---IDQGEYFFFvafeGGQIVGvialrdrghISLLFVDPDYQGQGIGKALLEavedY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 446493151   92 CMNSVSARTPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:pfam13673  80 AEKDGIKLSELTVNASPYAVPFYEKLGFRATG 111
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-128 5.30e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 49.65  E-value: 5.30e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446493151  58 AAIILYGEKVASIGMVIVHPDYKGRGIGKAITHSCMNSVSAR--TPIMLIATDE---GKYLYEKLGFRVVSYVSKY 128
Cdd:COG0456    4 LLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERgaRRLRLEVREDneaAIALYEKLGFEEVGERPNY 79
PTZ00330 PTZ00330
acetyltransferase; Provisional
 3-120 7.29e-08

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 50.61  E-value: 7.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   3 ELEIRVdrLREEEIGDIVALSSYI--GWDYSREEIETIFN----AGIVYGVWNER--KKLIASAAIILY------GEKVA 68
Cdd:PTZ00330   6 SLELRD--LEEGDLGSVLELLSHLtsAPALSQEELEQIAArrrlAGVVTRVFVHSptQRIVGTASLFVEpkftrgGKCVG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446493151  69 SIGMVIVHPDYKGRGIGKAITHSCMNSVSART--PIMLIATDEGKYLYEKLGFR 120
Cdd:PTZ00330  84 HIEDVVVDPSYRGQGLGRALISDLCEIARSSGcyKVILDCTEDMVAFYKKLGFR 137
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 49-152 1.06e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 46.97  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151  49 NERKKLIASAAIILYGEKVASIGMVIVHPDYKGRGIGKAITHSCM-----NSVSARTPIMLIATDEGKYLYEKLGFRVVS 123
Cdd:COG0454   40 DDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLewareRGCTALELDTLDGNPAAIRFYERLGFKEIE 119

                         90       100
                 ....*....|....*....|....*....
gi 446493151 124 yvskyicnsyntNYKCARNEEYMMDYEEG 152
Cdd:COG0454  120 ------------RYVAYVGGEFEKELSLS 136
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 47-121 5.25e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.98  E-value: 5.25e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446493151   47 VWNERKKLIASAAIILYGEKVASIG-MVIVHPDYKGRGIGKAITHSCMNSVSAR--TPIMLIATDEGKYLYEKLGFRV 121
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGgiKLLELETTNRAAAFYEKLGFEE 84
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 8-121 8.43e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 44.10  E-value: 8.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151    8 VDRLREEEIGDIVALSSYI-GWDYSREEIET---IFNAGIVYGVWNErKKLIASAAII-----LYGE--KVASIGMVIVH 76
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEYAfQDEDSPELREYfrpLLEEGRVLGAFDD-GELVSTLALYpfelnVPGKtlPAAGITGVATY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446493151   77 PDYKGRGIGKAITHSCMNSVSAR--TPIMLIATDEGkyLYEKLGFRV 121
Cdd:pfam13527  80 PEYRGRGVMSRLLRRSLEEMRERgvPLSFLYPSSYP--IYRRFGYEI 124
PRK07757 PRK07757
N-acetyltransferase;
31-123 9.98e-06

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 44.41  E-value: 9.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151  31 SREEI-ETIFNagivYGVWNERKKLIASAAIILYGEKVASIGMVIVHPDYKGRGIGKAITHSCMNsvsartpimlIATDE 109
Cdd:PRK07757  32 SLDELyENIRD----FYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIGRMLVEACLE----------EAREL 97

                         90       100
                 ....*....|....*....|....
gi 446493151 110 G----------KYLYEKLGFRVVS 123
Cdd:PRK07757  98 GvkrvfaltyqPEFFEKLGFREVD 121
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 29-119 1.30e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 40.58  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446493151   29 DYSREEIETIFNAGIVYGVWNERKKLIASAAIILYGE--KVASIGMVIVHPDYKGRGIGKAITHSCMNSVSAR--TPIML 104
Cdd:pfam00583  19 EPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERgcERIFL 98

                          90
                  ....*....|....*...
gi 446493151  105 IATDEGKY---LYEKLGF 119
Cdd:pfam00583  99 EVAADNLAaiaLYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-88 1.07e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.87  E-value: 1.07e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446493151  53 KLIASAAIILYG--EKVASIGMVIVHPDYKGRGIGKAI 88
Cdd:cd04301    9 EIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSAL 46
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 51-121 3.79e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 35.77  E-value: 3.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446493151   51 RKKLIASAAIIL---YGEkvasIGMVIVHPDYKGRGIGKAITHSCMNSVSAR--TPIMLIATDE--GKYLYEKLGFRV 121
Cdd:pfam08445   6 RGDTGELAAWCLrlpGGE----LGALQTLPEHRRRGLGSRLVAALARGIAERgiTPFAVVVAGNtpSRRLYEKLGFRK 79
PRK03624 PRK03624
putative acetyltransferase; Provisional
 75-126 8.66e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 35.67  E-value: 8.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446493151  75 VHPDYKGRGIGKAITHSCMNSVSAR--TPIMLI---ATDEGKYLYEKLGFRVVSYVS 126
Cdd:PRK03624  76 VHPDFRGRGIGRALVARLEKKLIARgcPKINLQvreDNDAVLGFYEALGYEEQDRIS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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