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Conserved domains on  [gi|446494025|ref|WP_000571879|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
13-91 6.64e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.55  E-value: 6.64e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446494025  13 IKKDFIDSQKVLLAIGDETRQAILLVLMETECqtglRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGEL----CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
13-91 6.64e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.55  E-value: 6.64e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446494025  13 IKKDFIDSQKVLLAIGDETRQAILLVLMETECqtglRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGEL----CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 22-91 1.82e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 72.88  E-value: 1.82e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494025  22 KVLLAIGDETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:NF033788   3 ELFKALADPTRLRILELLAEGE----LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 24-96 1.51e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 65.78  E-value: 1.51e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494025  24 LLAIGDETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYIDIRTKL 96
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGP----LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAERL 69
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 21-83 2.87e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 56.78  E-value: 2.87e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494025   21 QKVLLAIGDETRQAILLVLMETECQTglrVGEITKQTHLSRPAVSHHLKILREAGIILMRKEG 83
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLT---ASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
35-91 5.78e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 56.06  E-value: 5.78e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 446494025    35 ILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:smart00418   2 ILKLLAEGE----LCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLT 54
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 26-89 1.09e-11

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 55.88  E-value: 1.09e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446494025  26 AIGDETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGtKNFYY 89
Cdd:NF033789   4 ALSDPTRREILELLKEGD----MTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKG-QFIYY 62
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 27-83 5.65e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.12  E-value: 5.65e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446494025  27 IGDETRQAILLVLMETecqTGLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEG 83
Cdd:PRK10141  13 LSDETRLGIVLLLRES---GELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
13-91 6.64e-21

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.55  E-value: 6.64e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446494025  13 IKKDFIDSQKVLLAIGDETRQAILLVLMETECqtglRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGEL----CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 22-91 1.82e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 72.88  E-value: 1.82e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494025  22 KVLLAIGDETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:NF033788   3 ELFKALADPTRLRILELLAEGE----LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 24-96 1.51e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 65.78  E-value: 1.51e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494025  24 LLAIGDETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYIDIRTKL 96
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGP----LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAERL 69
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 21-83 2.87e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 56.78  E-value: 2.87e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494025   21 QKVLLAIGDETRQAILLVLMETECQTglrVGEITKQTHLSRPAVSHHLKILREAGIILMRKEG 83
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLT---ASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
35-91 5.78e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 56.06  E-value: 5.78e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 446494025    35 ILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYID 91
Cdd:smart00418   2 ILKLLAEGE----LCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLT 54
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 26-89 1.09e-11

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 55.88  E-value: 1.09e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446494025  26 AIGDETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEGtKNFYY 89
Cdd:NF033789   4 ALSDPTRREILELLKEGD----MTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKG-QFIYY 62
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 29-77 6.89e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.83  E-value: 6.89e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446494025   29 DETRQAILLVLMETEcqtgLRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:pfam01022   1 DPTRLKILKLLAEGE----LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
21-90 1.27e-10

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 54.88  E-value: 1.27e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494025  21 QKVLLAIGDETRQAILLVLMETECQTGlrvGEITKQTHLSRPAVSHHLKILREAGIILMRKEGTKNFYYI 90
Cdd:COG3398   88 KKILAYLRRETPRRILLYLLENPGATN---KELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYL 154
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
15-77 2.69e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 50.34  E-value: 2.69e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494025  15 KDFIDSQKVLLAIGDETRQAILLVLmeteCQTGLRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:COG4189    4 LDDEESLEVLKALASETRLRILRLL----AEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLI 62
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
19-94 1.29e-08

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 48.88  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494025  19 DSQKVLLAIGDETRQAILLVLMETECqtglRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEG-----TKNFYYIDIR 93
Cdd:COG1777    6 DLDRLLDALGNPTRRRILALLSEEPA----YVSELARELGVSRQAVYKHLRKLEEAGLVESYREGredgrARKYYRLSAF 81


                 .
gi 446494025  94 T 94
Cdd:COG1777   82 R 82
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 27-83 5.65e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.12  E-value: 5.65e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446494025  27 IGDETRQAILLVLMETecqTGLRVGEITKQTHLSRPAVSHHLKILREAGIILMRKEG 83
Cdd:PRK10141  13 LSDETRLGIVLLLRES---GELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
26-77 1.44e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 41.83  E-value: 1.44e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446494025  26 AIGDETRQAILLVLMEtecQTGLRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:COG2345    9 ALADPTRRRILELLKR---AGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
30-77 2.61e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.72  E-value: 2.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446494025  30 ETRQAILLVLMETECqtglRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:COG4742   16 EKRKNILLLLAEGPK----TRSELAESLDVSRSTILRQLKELEERGLI 59
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
30-77 2.77e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.18  E-value: 2.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446494025   30 ETRQAILLVLMETEcqtGLRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:pfam13412   1 ETDRKILNLLQENP---RISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
BirA COG1654
Biotin operon repressor [Transcription];
30-76 4.36e-03

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 35.35  E-value: 4.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446494025  30 ETRQAILLVLMETECQTGlrvGEITKQTHLSRPAVSHHLKILREAGI 76
Cdd:COG1654    4 STRLKLLRLLADGEFHSG---EELAEELGVSRAAVWKHIKALRELGY 47
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
29-77 4.83e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 34.37  E-value: 4.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446494025  29 DETRQAILLVLMEtECQTGLRvgEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:COG1522    4 DEIDRRILRLLQE-DGRLSFA--ELAERVGLSESTVLRRVRRLEEAGVI 49
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
35-77 5.25e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.18  E-value: 5.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446494025  35 ILLVLMETEcqtGLRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:COG1846   43 VLAALAEAG---GLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-77 6.48e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 32.56  E-value: 6.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446494025   34 AILLVLMETEcqtGLRVGEITKQTHLSRPAVSHHLKILREAGII 77
Cdd:pfam12802   9 RVLLALARNP---GLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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