|
Name |
Accession |
Description |
Interval |
E-value |
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
13-1239 |
0e+00 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 1822.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 13 QWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEenpVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEP 92
Cdd:TIGR02785 1 QWTDEQWQAIYTRGQDILVSASAGSGKTAVLVERIIRKITRG---VDVDRLLVVTFTNAAAREMKERIAEALEKELVQEP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 93 GSQHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRY 172
Cdd:TIGR02785 78 NSKHLRRQLALLNTANISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVFEEEYYKEDKEAFFELVDNF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 173 TSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGK-TIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPD 251
Cdd:TIGR02785 158 SGDRSDDGLRDLILQLYDFSRSTPNPEKWLNNLAEAYEVKEKfTIESLKLQQQIKELLKNELEGLQEKLQRALELFMAED 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 252 GPAPRIETLQADLALLGTLSSA--ARESWTSVYEAMQNVSWQTLKRIKKSDYNEDIVKQVDSLRNKAKDEVKKLQEELFS 329
Cdd:TIGR02785 238 GLAPRLENFQLDLQNIDELIQEslAQADWNELRKAVAAFKFKNLKAAKGDEEDADLLEEADKLREEAKKQLEKLKTDYFT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 330 RRPESFLRDFQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSEDgemkPSAVALQYRNKFAEVL 409
Cdd:TIGR02785 318 RSEEDHLRIMQEMKPVVKTLVQLVKDFIERFGAEKREKNILDFSDLEHYALQILTNENES----PSEAAEFYREKFHEVL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 410 VDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVL 489
Cdd:TIGR02785 394 VDEYQDTNLVQESILQLVKRGPEEEGNLFMVGDVKQSIYRFRQADPLLFLEKYHRFAQEGEEHGKRIDLAENFRSRAEVL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 490 AGTNFIFKQIMGEEVGEIDYDADAELKLG-ASYPEG-----EDVAAELLCIQQTEEEVIDgEEGAEVEKAQLEARLMAQR 563
Cdd:TIGR02785 474 DTTNFLFKQLMDEEVGEIDYDEEAQLKFGaAKYPENpdnktEELLYEKLLIEEAEEEEID-EEAEILDKAQQEATMVAER 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 564 IKAMVDSGYEVYDRKTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQ 643
Cdd:TIGR02785 553 IKALIKEGFKVYDKKTGTYRPVTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQ 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 644 DIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMSSFLKGAplEEEKELHDKLEWFYNLLQGWREFARQQSLSDLIWK 723
Cdd:TIGR02785 633 DIPLVAVLRSPIVGFDENELALIRLENKDSSYYEAVKDYVKAG--LIEDELYEKLNTFLDSLQKWREFARTHSVSELIWK 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 724 VYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKS 803
Cdd:TIGR02785 711 IYNDTGYYDYVGGLPGGKQRQANLYALYERARQYESTSFKGLFQFIRFIERMQERQKDLASAVAVGEAENAVRLMTIHKS 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 804 KGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKE 883
Cdd:TIGR02785 791 KGLEFPVVFVLGMGKQFNKQDLNSSYLLDRQLGLGIKYIDPQERLSYPSLPKVAIKQKMKRELLSEEMRVLYVALTRAKE 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 884 KLILIGTVKDATKEMEKWLDAREHSEWLLPDHVRAGASCYLDWIAPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEV 963
Cdd:TIGR02785 871 KLILVGSVKDEKKELKKWLAALAQSDWLLPENDRLQARNYLDWIGPALARHRDIKLLGDDAGVSIHDELTKDPANFAVEV 950
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 964 VDGNTLLAPEPVQ--EEKQELLEALREKKAVPLQSERKDEVYDRLMWKYGYEEATSHRAKQSVTEIKRNYQSE-EGSDNA 1040
Cdd:TIGR02785 951 IDSYDLLAEELEErmDEKSEQLEALADKNQSTGDKEFREKLREQLSYDYPHQAATETPAKQSVSEIKRIFEDEdEGSERA 1030
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1041 FIKKLRA--PIKTRPRFMEK-KGLTYAERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELLTFEQAEEIAVEKVISF 1117
Cdd:TIGR02785 1031 PVKQSRGksISLERPKFLTKtKGLTAAEIGTATHLVMQHIDLSKDPSEEELQQTIDRLVKKELLTEEQAEKIDIDKIVAF 1110
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1118 FDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGESGES-ILVQGVIDCMIEEEDGITLIDFKTDTIEGkfpGGFEQA 1196
Cdd:TIGR02785 1111 FDTPLGKQILKAKEVLRREPFFSMLISAEIYFDAHDEADEEdILVQGIIDGYYETEDGLYLFDYKTDHVEG---HGFEGA 1187
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|...
gi 446494438 1197 KPILETRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVIKV 1239
Cdd:TIGR02785 1188 INQLKERYRGQLQLYEKALEEIYKKKVKGKYLYLLDGDHVIDV 1230
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
12-1239 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 714.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 12 SQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIIneENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDE 91
Cdd:COG1074 4 PPWTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLL--ERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 92 PGS--------QHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTEnELLKEEVLDDILEEEYGIEDNT 163
Cdd:COG1074 82 DPDleelararRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAE-ALLLEEAVDDLLREAYAPLDAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 164 IFFELVDRYTsdRSDDDLQRMILALHtESRAHPNpekWLDKLVEAYDvegktiedlvyasylledvkfqletaeqhirka 243
Cdd:COG1074 161 ALARLLDAFG--RDDDSLEELLLALY-KLRSRPD---WLEELAELDE--------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 244 telamlpdgpapRIETLQADLAllgtlssaareswtsvyeamqnvswqtlkrikksdynedivkqvdslrnKAKDEVKKL 323
Cdd:COG1074 202 ------------ALEALREALL-------------------------------------------------KAKEALAAL 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 324 QEELFsrrpesflrdfQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSedgemkPSAVALQYRN 403
Cdd:COG1074 221 REALA-----------AAAAPLLAALLRLLAAVLARYERRKRERGLLDFDDLLHRALRLLRDED------APWVAERLRE 283
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 404 KFAEVLVDEYQDTNFVQESIIKFVTKDSESE-GNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFtqEGLGGGMKIDLAKNF 482
Cdd:COG1074 284 RYRHILVDEFQDTSPLQWEILRRLAGEALADgRTLFLVGDPKQSIYRFRGADPELFLEARRAL--EGRVDGERLTLTTNF 361
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 483 RSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGAsYPegedvAAELLciqqteeeVIDGEEGAEVEKAQLEARLMAQ 562
Cdd:COG1074 362 RSTPEVVDAVNALFAQLMGAGFGEIPYEPVEALRPGA-YP-----AVELW--------PLEPDDVSEEDAREREARAVAA 427
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 563 RIKAMVDSGYEVydrkTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPM 642
Cdd:COG1074 428 RIRRLLAEGTTV----EGGGRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFESPEVRDLLALLRALLNPE 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 643 QDIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMssflkgapleeekELHDKLEWFYNLLQGWREFARQQSLSDLIW 722
Cdd:COG1074 504 DDLALAAVLRSPLFGLSDEDLAALAADRKGESLWEAL-------------RAYERLARALERLRALRELARRLGLAELLE 570
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 723 KVYGETGYYDFVGGLPAGKQRQAN---LRVLYDRARQYEATSFRGLFRFLRFIERILERGDDmGTARALGEQEDVVRIMT 799
Cdd:COG1074 571 RLLEETGLLERLLALPGGERRLANllhLDELLQLALEYEQTGGPGLAGFLRWLERLIEDGGD-EEKRRLESDADAVRIMT 649
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 800 IHKSKGLEFPVVFVAglgrrfntqdlmkrfllhkdfgfgsqfidprkrikyttlsqlAIKRKMKMELIAEEMRVLYVALT 879
Cdd:COG1074 650 IHKSKGLEFPVVFLP------------------------------------------ALRERARAEELAEELRLLYVALT 687
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 880 RAKEKLILIGTVKDATKEmekwldarehsewllpdhvraGASCYLdwiapslyrhrdsemllelgqgsipdeiygydtsw 959
Cdd:COG1074 688 RARDRLVLSGAVKKKDAE---------------------KESSWL----------------------------------- 711
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 960 kvevvdgntllapepvqeekqellealrekkavplqserkdevydrlmwkygyeeatshrakqsvteikrnyqseegsdn 1039
Cdd:COG1074 --------------------------------------------------------------------------------
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1040 afikklrapiktrprfmekkgltyAERGTAVHAVMQHVDLKKPitvEVLQEQIAGMVNKELLTFEQAEEIAvEKVISFFD 1119
Cdd:COG1074 712 ------------------------ARRGTLVHRLLEHLDFSAP---AELRAALARLLARGGLDEEEAEALA-EALLAFLA 763
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1120 SDLGKRVLAAKSVEREVPFTMMlaaeeayqdwQGESGESILVQGVIDCMIEEEDGITLIDFKTDTIEgkfpggfEQAKPI 1199
Cdd:COG1074 764 TPLLAELFAAAEVLREVPFLLP----------DLYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLG-------PDDEEY 826
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|
gi 446494438 1200 LETRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVIKV 1239
Cdd:COG1074 827 LPERYRLQLALYALALERLLPGRPVRAGLYFTDRGRLVEI 866
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
14-465 |
4.24e-45 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 163.96 E-value: 4.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 14 WTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIinEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPg 93
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLI--LEGGIDPEEILAVTFTNKAAREMKERILKLLGKAELSEL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 94 sqhvrkqlsllnkaSISTIHSFCLQVIRGYYYMLDVDPRFRIanqtenellkeevlddileeeygiedntiffelvdryt 173
Cdd:pfam00580 78 --------------NISTFHSFCLRILRKYANRIGLLPNFSI-------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 174 sdrSDDDLQRMILAlhtesrahpnpekwldklveaydvegktiedlvyasyllEDVKFQLETAEQHIRKATELAMLpdgp 253
Cdd:pfam00580 106 ---LDELDQLALLK---------------------------------------ELLEKDRLNLDPKLLRKLELKEL---- 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 254 aprietlqadlallgtlssaareswtsvyeamqnvswqtlkrikksdynedivkqvdslrnkakdeVKKLQEELFSrrPE 333
Cdd:pfam00580 140 ------------------------------------------------------------------ISKAKNRLLS--PE 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 334 SFLRDFQDMHPvleklvQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSEdgemkpsaVALQYRNKFAEVLVDEY 413
Cdd:pfam00580 152 ELQQGAADPRD------KLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPE--------LLEAYRERFKYILVDEF 217
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 446494438 414 QDTNFVQESIIKFVTKDSEsegNLFMVGDVKQSIYRFRLAEPGLFLGKYKRF 465
Cdd:pfam00580 218 QDTNPIQYRLLKLLAGGHE---NLFLVGDPDQSIYGFRGADIENILKFEKDF 266
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
33-900 |
1.22e-35 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 147.04 E-value: 1.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 33 AAAGSGKTAVLVERIIKKIINEENPvdvDRLLVVTFTNAAAQEMKNRIGEALeKVLIDEPGSQH---VRKQLSL-----L 104
Cdd:PRK13909 5 ASAGSGKTFALSVRFLALLFKGANP---SEILALTFTKKAANEMKERIIDTL-LNLEKEKEESElneLEEKLGLskeelL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 105 NKA------------SISTIHSFCLQVIRGYYYMLDVDPRFRIANQTEnELLKEEVLDDILEEEYgiEDNTIFFELVDRY 172
Cdd:PRK13909 81 NKRdkvyqeflnselKISTIDAFFQKILRKFCLNLGLSPDFSIKEDTK-EELNEKFLSALSKEEL--LELLAFIKQCESK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 173 TSDRSDDDLQRMI---LALHTESRAHPNPEKWLDKLVEAydvegktiedlvyasylLEDVKFQLETAEQHIRKAtelaml 249
Cdd:PRK13909 158 KNNSFFELLEKLYeknNELKLFEKAKNPIEFDEEKFLEE-----------------LRSLKQQIQSIETASKNA------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 250 pdgpaprIETLQADLALLGTLSSaarESWTSvyeamQNVSWQTLKRIkksdYNEDIvkqvDSLRNKAKDEVKKLQEELfs 329
Cdd:PRK13909 215 -------KKAFKKEDFEELLNSS---KTWLE-----KESEYRYFKKL----YNEEL----DAEFEELKNALKRYYDAK-- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 330 rrpESFLrdFQDmhpvLEKLVQLVKVFTERFqamKRDKGMVDFTDLEHFCLQILSEQSEDGEMkpsavaLQYR--NKFAE 407
Cdd:PRK13909 270 ---ENYK--LSK----LFKLLQLYKEAKNEL---NKKKNALDFDDISKKVYELLGEEEIDKDF------LYFRldSKISH 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 408 VLVDEYQDTNFVQESIIK-----FVTKDSESE-GNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEglgggmkID-LAK 480
Cdd:PRK13909 332 ILIDEFQDTSVLQYKILLplideIKSGEGQKKfRSFFYVGDVKQSIYRFRGGKKELFDKVSKDFKQK-------VDnLDT 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 481 NFRSRHEVLAGTNFIFKQIMGEEVGEIdydadAELKLGASYpegedvaAELLCIQQTEEEVIDGeegaevekaqlearlM 560
Cdd:PRK13909 405 NYRSAPLIVDFVNEVFKKKYKNYKTQY-----AEQHKSGGY-------VEVVEVADESEELLEQ---------------L 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 561 AQRIKAMVDSGyevydrktdsmrpVQYRDFVILLRSMPWAPQIMEELKLQ-GIPVYADLATGYFEATEVNIMMNvfrvid 639
Cdd:PRK13909 458 LQEIQFLLEKG-------------IDPDDIAILCWTNDDALEIKEFLQEQfGIKAVTESSAKLINQPEVKALIE------ 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 640 npmqdiplaavlrspivglndeelATLRAHGKKgSFYEVmsSFLKGApleeeKELHDKLEWFYNLlqgwrefarQQSLSD 719
Cdd:PRK13909 519 ------------------------ALKYCLFGE-EIYKH--NVLKLL-----GKEPDKIPSFLPK---------EESVAE 557
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 720 LIWKVYGETGYYDfvgglpagkqrqANLRVLYDRARQYEatsfrglfRFLRFIERIlergDDMGTARALGEQeDVVRIMT 799
Cdd:PRK13909 558 FVKKLIEELKLYD------------ENLLKFLELASGYE--------DIEEFLFKL----EPCDKEIASEES-KGVQIMT 612
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 800 IHKSKGLEFPVVFVAGLGRRFNTQDlmKRFLLHKDFGFGsqfidprKRIKYTTLS--------QLAiKRKMKMELIAEEM 871
Cdd:PRK13909 613 VHKSKGLEFEHVIVCDRLGKPNSDS--SNLLFEYDGIEL-------WQIYYRIKGrenfdkdyARA-LEKEKALKYEEEI 682
|
890 900
....*....|....*....|....*....
gi 446494438 872 RVLYVALTRAKEKLILIGTVKDATKEMEK 900
Cdd:PRK13909 683 NVLYVAFTRAKNSLIVVKKDESSGSMFEI 711
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
371-482 |
6.57e-29 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 114.54 E-value: 6.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 371 DFTDLEHFCLQILSEQSEdgemkpsaVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSeseGNLFMVGDVKQSIYRF 450
Cdd:cd17932 94 DFDDLLLYALELLEENPD--------VREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDG---KNLFVVGDDDQSIYGF 162
|
90 100 110
....*....|....*....|....*....|..
gi 446494438 451 RLAEPGLFLGKYKRFtqeglGGGMKIDLAKNF 482
Cdd:cd17932 163 RGADPENILDFEKDF-----PDAKVIKLEENY 189
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
6-130 |
2.97e-03 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 40.55 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 6 PKKPEGSQWTDDQWKAV---VANGRDILVAAAAGSGKTAVLVERIIKKIINEENPvdvdRLLVVTFTNAAAQEMKNRIGE 82
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIealLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG----RVLVLVPTRELAEQWAEELKK 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446494438 83 ALEKVLIDEP---GSQHVRKQLSLLNKAS----ISTIHSFCLQVIRGYYYMLDVD 130
Cdd:smart00487 77 LGPSLGLKVVglyGGDSKREQLRKLESGKtdilVTTPGRLLDLLENDKLSLSNVD 131
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
13-1239 |
0e+00 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 1822.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 13 QWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEenpVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEP 92
Cdd:TIGR02785 1 QWTDEQWQAIYTRGQDILVSASAGSGKTAVLVERIIRKITRG---VDVDRLLVVTFTNAAAREMKERIAEALEKELVQEP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 93 GSQHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRY 172
Cdd:TIGR02785 78 NSKHLRRQLALLNTANISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVFEEEYYKEDKEAFFELVDNF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 173 TSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGK-TIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPD 251
Cdd:TIGR02785 158 SGDRSDDGLRDLILQLYDFSRSTPNPEKWLNNLAEAYEVKEKfTIESLKLQQQIKELLKNELEGLQEKLQRALELFMAED 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 252 GPAPRIETLQADLALLGTLSSA--ARESWTSVYEAMQNVSWQTLKRIKKSDYNEDIVKQVDSLRNKAKDEVKKLQEELFS 329
Cdd:TIGR02785 238 GLAPRLENFQLDLQNIDELIQEslAQADWNELRKAVAAFKFKNLKAAKGDEEDADLLEEADKLREEAKKQLEKLKTDYFT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 330 RRPESFLRDFQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSEDgemkPSAVALQYRNKFAEVL 409
Cdd:TIGR02785 318 RSEEDHLRIMQEMKPVVKTLVQLVKDFIERFGAEKREKNILDFSDLEHYALQILTNENES----PSEAAEFYREKFHEVL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 410 VDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVL 489
Cdd:TIGR02785 394 VDEYQDTNLVQESILQLVKRGPEEEGNLFMVGDVKQSIYRFRQADPLLFLEKYHRFAQEGEEHGKRIDLAENFRSRAEVL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 490 AGTNFIFKQIMGEEVGEIDYDADAELKLG-ASYPEG-----EDVAAELLCIQQTEEEVIDgEEGAEVEKAQLEARLMAQR 563
Cdd:TIGR02785 474 DTTNFLFKQLMDEEVGEIDYDEEAQLKFGaAKYPENpdnktEELLYEKLLIEEAEEEEID-EEAEILDKAQQEATMVAER 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 564 IKAMVDSGYEVYDRKTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQ 643
Cdd:TIGR02785 553 IKALIKEGFKVYDKKTGTYRPVTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQ 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 644 DIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMSSFLKGAplEEEKELHDKLEWFYNLLQGWREFARQQSLSDLIWK 723
Cdd:TIGR02785 633 DIPLVAVLRSPIVGFDENELALIRLENKDSSYYEAVKDYVKAG--LIEDELYEKLNTFLDSLQKWREFARTHSVSELIWK 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 724 VYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKS 803
Cdd:TIGR02785 711 IYNDTGYYDYVGGLPGGKQRQANLYALYERARQYESTSFKGLFQFIRFIERMQERQKDLASAVAVGEAENAVRLMTIHKS 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 804 KGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKE 883
Cdd:TIGR02785 791 KGLEFPVVFVLGMGKQFNKQDLNSSYLLDRQLGLGIKYIDPQERLSYPSLPKVAIKQKMKRELLSEEMRVLYVALTRAKE 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 884 KLILIGTVKDATKEMEKWLDAREHSEWLLPDHVRAGASCYLDWIAPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEV 963
Cdd:TIGR02785 871 KLILVGSVKDEKKELKKWLAALAQSDWLLPENDRLQARNYLDWIGPALARHRDIKLLGDDAGVSIHDELTKDPANFAVEV 950
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 964 VDGNTLLAPEPVQ--EEKQELLEALREKKAVPLQSERKDEVYDRLMWKYGYEEATSHRAKQSVTEIKRNYQSE-EGSDNA 1040
Cdd:TIGR02785 951 IDSYDLLAEELEErmDEKSEQLEALADKNQSTGDKEFREKLREQLSYDYPHQAATETPAKQSVSEIKRIFEDEdEGSERA 1030
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1041 FIKKLRA--PIKTRPRFMEK-KGLTYAERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELLTFEQAEEIAVEKVISF 1117
Cdd:TIGR02785 1031 PVKQSRGksISLERPKFLTKtKGLTAAEIGTATHLVMQHIDLSKDPSEEELQQTIDRLVKKELLTEEQAEKIDIDKIVAF 1110
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1118 FDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGESGES-ILVQGVIDCMIEEEDGITLIDFKTDTIEGkfpGGFEQA 1196
Cdd:TIGR02785 1111 FDTPLGKQILKAKEVLRREPFFSMLISAEIYFDAHDEADEEdILVQGIIDGYYETEDGLYLFDYKTDHVEG---HGFEGA 1187
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|...
gi 446494438 1197 KPILETRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVIKV 1239
Cdd:TIGR02785 1188 INQLKERYRGQLQLYEKALEEIYKKKVKGKYLYLLDGDHVIDV 1230
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
12-1239 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 714.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 12 SQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIIneENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDE 91
Cdd:COG1074 4 PPWTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLL--ERGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 92 PGS--------QHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTEnELLKEEVLDDILEEEYGIEDNT 163
Cdd:COG1074 82 DPDleelararRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAE-ALLLEEAVDDLLREAYAPLDAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 164 IFFELVDRYTsdRSDDDLQRMILALHtESRAHPNpekWLDKLVEAYDvegktiedlvyasylledvkfqletaeqhirka 243
Cdd:COG1074 161 ALARLLDAFG--RDDDSLEELLLALY-KLRSRPD---WLEELAELDE--------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 244 telamlpdgpapRIETLQADLAllgtlssaareswtsvyeamqnvswqtlkrikksdynedivkqvdslrnKAKDEVKKL 323
Cdd:COG1074 202 ------------ALEALREALL-------------------------------------------------KAKEALAAL 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 324 QEELFsrrpesflrdfQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSedgemkPSAVALQYRN 403
Cdd:COG1074 221 REALA-----------AAAAPLLAALLRLLAAVLARYERRKRERGLLDFDDLLHRALRLLRDED------APWVAERLRE 283
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 404 KFAEVLVDEYQDTNFVQESIIKFVTKDSESE-GNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFtqEGLGGGMKIDLAKNF 482
Cdd:COG1074 284 RYRHILVDEFQDTSPLQWEILRRLAGEALADgRTLFLVGDPKQSIYRFRGADPELFLEARRAL--EGRVDGERLTLTTNF 361
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 483 RSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGAsYPegedvAAELLciqqteeeVIDGEEGAEVEKAQLEARLMAQ 562
Cdd:COG1074 362 RSTPEVVDAVNALFAQLMGAGFGEIPYEPVEALRPGA-YP-----AVELW--------PLEPDDVSEEDAREREARAVAA 427
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 563 RIKAMVDSGYEVydrkTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPM 642
Cdd:COG1074 428 RIRRLLAEGTTV----EGGGRPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFESPEVRDLLALLRALLNPE 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 643 QDIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMssflkgapleeekELHDKLEWFYNLLQGWREFARQQSLSDLIW 722
Cdd:COG1074 504 DDLALAAVLRSPLFGLSDEDLAALAADRKGESLWEAL-------------RAYERLARALERLRALRELARRLGLAELLE 570
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 723 KVYGETGYYDFVGGLPAGKQRQAN---LRVLYDRARQYEATSFRGLFRFLRFIERILERGDDmGTARALGEQEDVVRIMT 799
Cdd:COG1074 571 RLLEETGLLERLLALPGGERRLANllhLDELLQLALEYEQTGGPGLAGFLRWLERLIEDGGD-EEKRRLESDADAVRIMT 649
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 800 IHKSKGLEFPVVFVAglgrrfntqdlmkrfllhkdfgfgsqfidprkrikyttlsqlAIKRKMKMELIAEEMRVLYVALT 879
Cdd:COG1074 650 IHKSKGLEFPVVFLP------------------------------------------ALRERARAEELAEELRLLYVALT 687
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 880 RAKEKLILIGTVKDATKEmekwldarehsewllpdhvraGASCYLdwiapslyrhrdsemllelgqgsipdeiygydtsw 959
Cdd:COG1074 688 RARDRLVLSGAVKKKDAE---------------------KESSWL----------------------------------- 711
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 960 kvevvdgntllapepvqeekqellealrekkavplqserkdevydrlmwkygyeeatshrakqsvteikrnyqseegsdn 1039
Cdd:COG1074 --------------------------------------------------------------------------------
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1040 afikklrapiktrprfmekkgltyAERGTAVHAVMQHVDLKKPitvEVLQEQIAGMVNKELLTFEQAEEIAvEKVISFFD 1119
Cdd:COG1074 712 ------------------------ARRGTLVHRLLEHLDFSAP---AELRAALARLLARGGLDEEEAEALA-EALLAFLA 763
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1120 SDLGKRVLAAKSVEREVPFTMMlaaeeayqdwQGESGESILVQGVIDCMIEEEDGITLIDFKTDTIEgkfpggfEQAKPI 1199
Cdd:COG1074 764 TPLLAELFAAAEVLREVPFLLP----------DLYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLG-------PDDEEY 826
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|
gi 446494438 1200 LETRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVIKV 1239
Cdd:COG1074 827 LPERYRLQLALYALALERLLPGRPVRAGLYFTDRGRLVEI 866
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
12-887 |
1.22e-81 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 283.36 E-value: 1.22e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 12 SQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIiKKIINEENpVDVDRLLVVTFTNAAAQEMKNRIGEALEKvlide 91
Cdd:COG0210 5 AGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRI-AYLIAEGG-VDPEQILAVTFTNKAAREMRERIEALLGR----- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 92 pgsqhvrkqlsLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIanqtenellkeevLDDileeeygiedntiffelvdr 171
Cdd:COG0210 78 -----------LARGLWVGTFHSLALRILRRHAELLGLPPNFTI-------------LDG-------------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 172 ytsdrsdDDLQRMIlalhtesrahpnpekwlDKLVEAYDVEGKtiedlvyasylledvKFQLETAEQHIrkatelamlpd 251
Cdd:COG0210 114 -------DDQLRLI-----------------KELLKELGLDEK---------------RFPPRELLSLI----------- 143
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 252 gpaprietlqadlallgtlssaareswtsvyeamqnvswqtlkrikksdynedivkqvdslrNKAKDEVkklqeelfsRR 331
Cdd:COG0210 144 --------------------------------------------------------------SRAKNEG---------LT 152
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 332 PESFLRDFQDmhpvLEKLVQLVKVFtERFQAMKRDKGMVDFTDLEHFCLQILSEQSEdgemkpsaVALQYRNKFAEVLVD 411
Cdd:COG0210 153 PEELAELLAA----DPEWRAAAELY-EAYQERLRANNALDFDDLLLLAVRLLEENPE--------VLEKYQNRFRYILVD 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 412 EYQDTNFVQESIIKFVTKDSeseGNLFMVGDVKQSIYRFRLAEPGLFLgkykRFTQEgLGGGMKIDLAKNFRSRHEVLAG 491
Cdd:COG0210 220 EYQDTNPAQYELLRLLAGDG---RNLCVVGDDDQSIYGFRGADPENIL----RFEKD-FPDAKVIKLEQNYRSTQNILDA 291
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 492 TNFIFKQIMGEEvgeidydadaELKLGASYPEGEDVAAELLciqQTEEEvidgeegaevekaqlEARLMAQRIKAMVDSG 571
Cdd:COG0210 292 ANAVIANNPGRL----------GKNLWTDNGEGEKVRLYVA---PDEEE---------------EARFVADEIRELHEEG 343
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 572 YevydrktdsmrpvQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVL 651
Cdd:COG0210 344 V-------------PLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLANPDDDVALLRIL 410
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 652 RSPIVGLNDEELATLR--AHGKKGSFYEVMSSFLKGAPLEEEKelHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETG 729
Cdd:COG0210 411 NVPRRGIGAATLERLReaAREEGISLLEALRDLGELAGLSGRA--AKALRRFAELLEALRAAAERLPLEELLEALLDESG 488
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 730 YYDFVGGL--PAGKQRQANLRVLYDRARQYEATSFRGlfRFLRFIERI-LERGDDmgtarALGEQEDVVRIMTIHKSKGL 806
Cdd:COG0210 489 YEEELREEagEEAERRLENLEELVDAAARFEERNPGA--SLEAFLEELaLLSDLD-----AADEDEDAVTLMTLHAAKGL 561
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 807 EFPVVFVAGLgrrfnTQDLMkrfllhkdfgfgsqfidPRKRikyttlsqlAIKRKmkmELIAEEMRVLYVALTRAKEKLI 886
Cdd:COG0210 562 EFPVVFLVGL-----EEGLF-----------------PHQR---------SLDDE---EELEEERRLFYVAITRARERLY 607
|
.
gi 446494438 887 L 887
Cdd:COG0210 608 L 608
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
31-1217 |
5.44e-73 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 265.78 E-value: 5.44e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 31 VAAAAGSGKTAVLVERIIKKIINEENPvdvDRLLVVTFTNAAAQEMKNRI---------------GEALEKVLIDEPGSQ 95
Cdd:TIGR02784 15 VSANAGSGKTHVLTQRVIRLLLAGTEP---SKILCLTYTKAAAAEMQNRVfkrlgewavlddadlRARLEALEGKRPDAA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 96 HVRKQLSLLNKA-------SISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGieDNTIFFEL 168
Cdd:TIGR02784 92 KLAEARRLFARAletpgglKIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLEEARRALLAGPAA--PDDALADA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 169 VDRYTSDRSDDDLQRMILALhTESRAHPnpEKWLD---------KLVEAYDVE-GKTIEDLVYASY--------LLEDVK 230
Cdd:TIGR02784 170 LATVLEAAGETGLEALLAEI-VARRDAL--MAFLDeaggegaeaRLRRALGLApGDTAEDLLEAVWplpglprlALALIA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 231 FQLE--TAEQHIRKATELAMLPDGPAPRIETLQADLALLGTLSSAARESwtsvyeamqnvSWQTLKRIKKSdyNEDIVKQ 308
Cdd:TIGR02784 247 ALLKsgGGSKDAAAALSQLREAAAEPDPVARLDLLLGAFLTSKGEPKSA-----------SFVIKKAIQKS--LPDLAEA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 309 VDSLRNKAKDEVKKLQEELFSRRPESFLRdfqdmhpvleklvqLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSE 388
Cdd:TIGR02784 314 LEDAASRVEALRERLRALRMAQRTLAALR--------------LAARLLQRYARLKKARGLLDFNDLIERTVALLARPGA 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 389 dgemkpsAVALQYR--NKFAEVLVDEYQDTNFVQESIIKFVTKD--------SESEGNLFMVGDVKQSIYRFRLAEPGLF 458
Cdd:TIGR02784 380 -------GAWVHYKldRGIDHILVDEAQDTSPEQWDIIQALAEEffsgegarSGVERTIFAVGDEKQSIYSFQGADPERF 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 459 L----GKYKRFTQEGLgGGMKIDLAKNFRSRHEVLAGTNFIFkqimgeevgeidydADAELKLGASYPEGE--------- 525
Cdd:TIGR02784 453 AeerrEFSRKVRAVGR-KFEDLSLNYSFRSTPDVLAAVDLVF--------------ADPENARGLSADSDApvheafrdd 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 526 --------DVAAELLCIQQTEEEVIDGEEGAEVEKAQLeARLMAQRIKAMVDSGYEVYDRKtdsmRPVQYRDFVILLRSM 597
Cdd:TIGR02784 518 lpgrvdlwDLISKEEGEEPEDWTDPVDELGERAPEVRL-AERIAAEIRAWLDRGTPIPGRG----RAVRPGDILVLVRKR 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 598 P-WAPQIMEELKLQGIPVY-AD-LATGYFEAteVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLRAHGKKGS 674
Cdd:TIGR02784 593 DaFFSALIRALKRRGIPVAgADrLKLTSHIA--VKDLMALGRFVLQPEDDLSLAALLKSPLFGLDEDDLFRLAAGRSGGS 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 675 FYEVMssflkGAPLEEEKELHDKLEWfynllqgWREFARQQSLSDLIWKVYGETGyydfvgglpaGKQR-------QAN- 746
Cdd:TIGR02784 671 LWAAL-----RRREAEFAATLAVLRD-------WLSLADFLTPFEFYARLLGRDG----------GRRKllarlgaEAEd 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 747 -LRVLYDRARQYEATSFRGLFRFLRFIErilerGDDMGTARALGEQEDVVRIMTIHKSKGLEFPVVFVA-GLGRRFNTQD 824
Cdd:TIGR02784 729 iLDEFLSQALAYERTGLPGLQAFLSWLE-----ADDPEIKREMDQARDEVRVMTVHGAKGLEAPVVFLVdTGSKPFASQR 803
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 825 LMKrflLHKDFGFGSQFIDPRKRIKY-TTLSQLAIKRKMKMELiAEEMRVLYVALTRAKEKLILIGTVKDATKEMEKWLD 903
Cdd:TIGR02784 804 APL---LLATGGSGGKAPLWRPASAFdPSLSAAARERLKERAE-DEYRRLLYVAMTRAEDRLIVCGYRGKRESPKDSWHA 879
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 904 ArehsewllpdhVRAGascyldwiapslyrhrdsemLLELGQGSIPDEIYGYDTSWKVEVVDGntllAPEPVQEEKQELL 983
Cdd:TIGR02784 880 L-----------VKRA--------------------LAAAGIAWQEPHPAQGKAEWRLRFTRR----DWDPVGLPVEAAQ 924
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 984 EALREkkAVPlqserkdevyDRLMWKYGYEEATSHRAKQSVTEiKRNYQSEEGSDNAFIKKLRAPiktrprfmekkgLTY 1063
Cdd:TIGR02784 925 TDTLE--ALP----------DWLRAPAPAEPALPRPLAPSGLG-GAIDSALPGEAVRSSLGTQAP------------AFA 979
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1064 AERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELltFEQAEEIAVEKVISFFDSDLGKRVLAAKSVErEVPFTMMLa 1143
Cdd:TIGR02784 980 LLRGTLLHRLLQHLPDLPPEEREDAARRYLARSAADW--PEAEREALLAAVLAVLDDPRLAPVFAPGSRA-EVAIMGTL- 1055
|
1210 1220 1230 1240 1250 1260 1270
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446494438 1144 aeeayqdwqGESGESILVQGVIDCMIEEEDGITLIDFKTDTIEgkfPGGFEQAKPIletrYKVQLSLYAKALEK 1217
Cdd:TIGR02784 1056 ---------KEGGQQLAVSGQIDRLAVDRDRVLIVDYKTNRPV---PATAEEVPPA----YLRQLALYRALLRP 1113
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
29-1221 |
6.34e-56 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 212.29 E-value: 6.34e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 29 ILVAAAAGSGKT---AVLVERIIKkiinEENPVDVDRLLVVTFTNAAAQEMKNRIGEALE---KVLIDEPGSQH------ 96
Cdd:TIGR00609 12 FLIEASAGTGKTftiAQLYLRLLL----EGGPLTVEEILVVTFTNAATEELKTRIRGRIHqalRALKAALTSQElpeplk 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 97 --------------VRKQLSLLNKASISTIHSFCLQVIRGYYYmlDVDPRFRIANQTENELLKEEVLDDI-LEEEYGIED 161
Cdd:TIGR00609 88 eaiqdekvkqaitrLRNALATMDEAAIYTIHGFCQRMLEQHAF--ESDEIFDVELIEDESLLLAEITKDFwRRNFYNLPF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 162 NTIFFELVDRYTSDrsdddlqrmilALHTESRAhpnpekwlDKLVEAYDvegktiedlvYASYLLEDVKFQLETAEQHIR 241
Cdd:TIGR00609 166 DIAQIVLKTKKSPQ-----------AVLTQILA--------DLLLQSYL----------AFPSPPLDLEQLIKWHEQIYK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 242 KATELamlpdgPAPRIETLQADLALLGTLSSaareswtsvyeamqnvswqtlkrikksdynedivkQVDSLRNKAkdeVK 321
Cdd:TIGR00609 217 DLDKL------DHAVFEEIDKLNAERNNLFC-----------------------------------LKDRVFLTL---LK 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 322 KLQEELFSRRPESFLRDFQDMHPVLEKLVQlvkvfterfqamkrdkgmvdftdlehfclqilseqSEDGEmkpsAVALQY 401
Cdd:TIGR00609 253 EVQEELKKEKKRRREIGFDDLLSRLETALK-----------------------------------SAEGE----KLAQAI 293
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 402 RNKFAEVLVDEYQDTNFVQESIIKFVtKDSESEGNLFMVGDVKQSIYRFRLAEpgLFLGKY------KRFTqeglgggmk 475
Cdd:TIGR00609 294 REQYPIALIDEFQDTDPQQYRIFSKL-FIAQKETSLFLIGDPKQAIYSFRGAD--IFTYLQakskadARYT--------- 361
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 476 idLAKNFRSRHEVLAGTNFIFKQIMGEEVGEIDY----DADAELKLGASYPeGEDVAAELLCIQQTEEEVIDGEEgaeVE 551
Cdd:TIGR00609 362 --LGTNWRSTPALVGSLNKLFSLISNPFLEKPIFipvlAHQKNSKGSFVIN-GQEQPPIHFFTTEVESEGVDDYR---QT 435
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 552 KAQLEARLMAQRIKAmvDSGYEVYDRKTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIP-VYADLATGYFEATEVNI 630
Cdd:TIGR00609 436 IAQKCAREIALWLAS--AALGLANFIATFGGRPLRAGDIAVLVRGRKEANQIRKALKKAQIPsVYLSDKSSVFATEEAQE 513
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 631 MMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLrahgkkgsfyevmssflkgapleeekeLHDKLEW--FYNLLQGW 708
Cdd:TIGR00609 514 LLALLEALLEPENEGTLRAALASSIFGLSALELETL---------------------------NQDEITWerVVEKFREY 566
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 709 REFARQQSLSDLIWKVYGETGYYDFVGGLPAGKQRQANLRVLYDRArQYEATSFRGLFRFLR-FIERILERGDDMGTARA 787
Cdd:TIGR00609 567 HDIWRKIGVLAMFQRLMLEKGIGERLLSQPGGERILTNLLHLAELL-QEAAHQERNKLSLLRwLEDQISNEEEEEEEIIR 645
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 788 LGEQEDVVRIMTIHKSKGLEFPVVFVAGLgrrFNTQDLmKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLaikrkmkmELI 867
Cdd:TIGR00609 646 LESDAELVKIVTIHKSKGLEYPIVFLPFI---TDAKKS-NFASLHDQHSHEYQLYDFNQSEENQKLARV--------ERL 713
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 868 AEEMRVLYVALTRAKEKLILigtvkdatkemekwldarehsewllpdhvragascyldWIAPSLYRHRDSEMLLELGQGS 947
Cdd:TIGR00609 714 AEDLRLLYVALTRAKKQLFI--------------------------------------GIAPLITSKLSNLAYSALHNSA 755
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 948 I--------PDEIYGYDTSWKVEVVDGNTLLAPEPVQEE----KQELLEALREKKAVPLQSERKDEVYDrlmwkYGYEEA 1015
Cdd:TIGR00609 756 LgyqkqdgeTDNITGLKQCLAALADPAGISSIPAKPIGAnsskKEPASTALLEARTFHRRIRENWRITS-----FSSLKE 830
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1016 TSHrakqSVTEIKRNYQSEEGSdNAFIKKLRAPIKTRPrfmekkgltyaerGTAVHAVMQHVDLKKPITVEVLQEQIAGM 1095
Cdd:TIGR00609 831 LEE----AVTEEPAPGLDYEVS-SLEISAQDFPKGKKT-------------GTLLHAILESLIFSQAADLEKQNNLIAEK 892
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1096 VNKELLTFEQAEEIAvEKVISFFDSDLGK------RVLAAKSVEREVPFTMMLAAE----------EAYQDWQGESGESI 1159
Cdd:TIGR00609 893 LKKTGLEGLWEPELQ-EWLEKMLNTPLTFsraitlSQIDPEDRQREMEFLLPINPEfqkqklnfviRAYPDRAGSPDLHF 971
|
1210 1220 1230 1240 1250 1260 1270
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1160 -----LVQGVIDCMIEEEDGITLIDFKTDTIeGKFPGGFEQAK---PILETRYKVQLSLYAKALEKSLQH 1221
Cdd:TIGR00609 972 qllrgLLKGFIDLVFEHNGRYYILDYKSNWL-GKDASDYSPEAlteAILKERYDLQYLIYTLALHRYLRK 1040
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
14-465 |
4.24e-45 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 163.96 E-value: 4.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 14 WTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIinEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPg 93
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLI--LEGGIDPEEILAVTFTNKAAREMKERILKLLGKAELSEL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 94 sqhvrkqlsllnkaSISTIHSFCLQVIRGYYYMLDVDPRFRIanqtenellkeevlddileeeygiedntiffelvdryt 173
Cdd:pfam00580 78 --------------NISTFHSFCLRILRKYANRIGLLPNFSI-------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 174 sdrSDDDLQRMILAlhtesrahpnpekwldklveaydvegktiedlvyasyllEDVKFQLETAEQHIRKATELAMLpdgp 253
Cdd:pfam00580 106 ---LDELDQLALLK---------------------------------------ELLEKDRLNLDPKLLRKLELKEL---- 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 254 aprietlqadlallgtlssaareswtsvyeamqnvswqtlkrikksdynedivkqvdslrnkakdeVKKLQEELFSrrPE 333
Cdd:pfam00580 140 ------------------------------------------------------------------ISKAKNRLLS--PE 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 334 SFLRDFQDMHPvleklvQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSEdgemkpsaVALQYRNKFAEVLVDEY 413
Cdd:pfam00580 152 ELQQGAADPRD------KLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPE--------LLEAYRERFKYILVDEF 217
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 446494438 414 QDTNFVQESIIKFVTKDSEsegNLFMVGDVKQSIYRFRLAEPGLFLGKYKRF 465
Cdd:pfam00580 218 QDTNPIQYRLLKLLAGGHE---NLFLVGDPDQSIYGFRGADIENILKFEKDF 266
|
|
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
18-887 |
4.86e-40 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 159.55 E-value: 4.86e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 18 QWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIinEENPVDVDRLLVVTFTNAAAQEMKNRIGealekvlidepgsqhv 97
Cdd:TIGR01073 9 QREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLI--AEKNVAPWNILAITFTNKAAREMKERVE---------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 98 rkqlSLLNKAS----ISTIHSFCLQVIRgyyymldvdprfrianqtenellkeevlDDIleEEYGIEDNtifFELVDryt 173
Cdd:TIGR01073 71 ----KLLGPVAediwISTFHSMCVRILR----------------------------RDI--DRIGINRN---FSIID--- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 174 sdrsDDDLQRMIlalhtesrahpnpekwldklveaydvegKTIedlvyasylledvkfqletaeqhirkATELAMLPDGP 253
Cdd:TIGR01073 111 ----PTDQLSLM----------------------------KTI--------------------------LKDKNLDPKKF 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 254 APRietlqadlALLGTLSSAareswtsvyeamqnvswqtlkrikksdynedivkqvdslrnkaKDEVkkLQEELFSRRPE 333
Cdd:TIGR01073 133 EPR--------SILGTISNA-------------------------------------------KNEL--LPPEDFAKEAT 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 334 SFLrdfqdmhpvlEKLVQLVkvfTERFQAMKRDKGMVDFTDLEHFCLQILsEQSEDgemkpsaVALQYRNKFAEVLVDEY 413
Cdd:TIGR01073 160 NYF----------EKVVAEV---YQEYQKRLLRNNALDFDDLIMTTINLF-QRVPD-------VLEYYQRKFQYIHVDEY 218
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 414 QDTNFVQESIIKFVtkdSESEGNLFMVGDVKQSIYRFRLAEPGLFLgkykRFtQEGLGGGMKIDLAKNFRSRHEVLAGTN 493
Cdd:TIGR01073 219 QDTNRAQYTLVRLL---ASRFRNLCVVGDADQSIYGWRGADIQNIL----SF-EKDYPNATTILLEQNYRSTKNILQAAN 290
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 494 fifkqimgeEVgeIDYDADAELK-LGASYPEGEDVaaeLLCIQQTEEEvidgeegaevekaqlEARLMAQRIKAMVDSGY 572
Cdd:TIGR01073 291 ---------EV--IEHNSNRKPKnLWTENSSGDKI---TYYEADTERD---------------EAQFVAGEIDKLVKNGE 341
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 573 evydrktdsmrpVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLR 652
Cdd:TIGR01073 342 ------------RKYGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILAYLRVIANPDDDLSLLRIIN 409
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 653 SPIVGLNDEELATLRAHGK--KGSFYEVMSSFLKGAPLeeEKELHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETGY 730
Cdd:TIGR01073 410 VPKRGIGASSLEKIVNYALelNISLFEAIGEIDEIGGL--AAKSANALLAFATMIENLRQQQEYLSPTELVEEVLDKSGY 487
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 731 YDFVG--GLPAGKQRQANLRVLYDRARQYEATSFRG-LFRFLRFIERILERgDDMGTAralgEQEDVVRIMTIHKSKGLE 807
Cdd:TIGR01073 488 REMLKaeKTEEAQSRLENLDEFLSVTKEFEDESEDKsLIDFLTDLALVSDL-DELEET----EEGGAVTLMTLHAAKGLE 562
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 808 FPVVFVAGLgrrfntqdlmkrfllhkdfgfgSQFIDPRKRikyttlsqlAIKRKMKMEliaEEMRVLYVALTRAKEKLIL 887
Cdd:TIGR01073 563 FPVVFLIGM----------------------EEGVFPHSR---------SLMDEKELE---EERRLAYVGITRAEEELYL 608
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
33-900 |
1.22e-35 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 147.04 E-value: 1.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 33 AAAGSGKTAVLVERIIKKIINEENPvdvDRLLVVTFTNAAAQEMKNRIGEALeKVLIDEPGSQH---VRKQLSL-----L 104
Cdd:PRK13909 5 ASAGSGKTFALSVRFLALLFKGANP---SEILALTFTKKAANEMKERIIDTL-LNLEKEKEESElneLEEKLGLskeelL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 105 NKA------------SISTIHSFCLQVIRGYYYMLDVDPRFRIANQTEnELLKEEVLDDILEEEYgiEDNTIFFELVDRY 172
Cdd:PRK13909 81 NKRdkvyqeflnselKISTIDAFFQKILRKFCLNLGLSPDFSIKEDTK-EELNEKFLSALSKEEL--LELLAFIKQCESK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 173 TSDRSDDDLQRMI---LALHTESRAHPNPEKWLDKLVEAydvegktiedlvyasylLEDVKFQLETAEQHIRKAtelaml 249
Cdd:PRK13909 158 KNNSFFELLEKLYeknNELKLFEKAKNPIEFDEEKFLEE-----------------LRSLKQQIQSIETASKNA------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 250 pdgpaprIETLQADLALLGTLSSaarESWTSvyeamQNVSWQTLKRIkksdYNEDIvkqvDSLRNKAKDEVKKLQEELfs 329
Cdd:PRK13909 215 -------KKAFKKEDFEELLNSS---KTWLE-----KESEYRYFKKL----YNEEL----DAEFEELKNALKRYYDAK-- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 330 rrpESFLrdFQDmhpvLEKLVQLVKVFTERFqamKRDKGMVDFTDLEHFCLQILSEQSEDGEMkpsavaLQYR--NKFAE 407
Cdd:PRK13909 270 ---ENYK--LSK----LFKLLQLYKEAKNEL---NKKKNALDFDDISKKVYELLGEEEIDKDF------LYFRldSKISH 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 408 VLVDEYQDTNFVQESIIK-----FVTKDSESE-GNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEglgggmkID-LAK 480
Cdd:PRK13909 332 ILIDEFQDTSVLQYKILLplideIKSGEGQKKfRSFFYVGDVKQSIYRFRGGKKELFDKVSKDFKQK-------VDnLDT 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 481 NFRSRHEVLAGTNFIFKQIMGEEVGEIdydadAELKLGASYpegedvaAELLCIQQTEEEVIDGeegaevekaqlearlM 560
Cdd:PRK13909 405 NYRSAPLIVDFVNEVFKKKYKNYKTQY-----AEQHKSGGY-------VEVVEVADESEELLEQ---------------L 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 561 AQRIKAMVDSGyevydrktdsmrpVQYRDFVILLRSMPWAPQIMEELKLQ-GIPVYADLATGYFEATEVNIMMNvfrvid 639
Cdd:PRK13909 458 LQEIQFLLEKG-------------IDPDDIAILCWTNDDALEIKEFLQEQfGIKAVTESSAKLINQPEVKALIE------ 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 640 npmqdiplaavlrspivglndeelATLRAHGKKgSFYEVmsSFLKGApleeeKELHDKLEWFYNLlqgwrefarQQSLSD 719
Cdd:PRK13909 519 ------------------------ALKYCLFGE-EIYKH--NVLKLL-----GKEPDKIPSFLPK---------EESVAE 557
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 720 LIWKVYGETGYYDfvgglpagkqrqANLRVLYDRARQYEatsfrglfRFLRFIERIlergDDMGTARALGEQeDVVRIMT 799
Cdd:PRK13909 558 FVKKLIEELKLYD------------ENLLKFLELASGYE--------DIEEFLFKL----EPCDKEIASEES-KGVQIMT 612
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 800 IHKSKGLEFPVVFVAGLGRRFNTQDlmKRFLLHKDFGFGsqfidprKRIKYTTLS--------QLAiKRKMKMELIAEEM 871
Cdd:PRK13909 613 VHKSKGLEFEHVIVCDRLGKPNSDS--SNLLFEYDGIEL-------WQIYYRIKGrenfdkdyARA-LEKEKALKYEEEI 682
|
890 900
....*....|....*....|....*....
gi 446494438 872 RVLYVALTRAKEKLILIGTVKDATKEMEK 900
Cdd:PRK13909 683 NVLYVAFTRAKNSLIVVKKDESSGSMFEI 711
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
371-482 |
6.57e-29 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 114.54 E-value: 6.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 371 DFTDLEHFCLQILSEQSEdgemkpsaVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSeseGNLFMVGDVKQSIYRF 450
Cdd:cd17932 94 DFDDLLLYALELLEENPD--------VREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDG---KNLFVVGDDDQSIYGF 162
|
90 100 110
....*....|....*....|....*....|..
gi 446494438 451 RLAEPGLFLGKYKRFtqeglGGGMKIDLAKNF 482
Cdd:cd17932 163 RGADPENILDFEKDF-----PDAKVIKLEENY 189
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
15-124 |
6.70e-29 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 114.54 E-value: 6.70e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 15 TDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIinEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKvlidepgs 94
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLI--LEGGVPPERILAVTFTNKAAKEMRERLRKLLGE-------- 70
|
90 100 110
....*....|....*....|....*....|
gi 446494438 95 qhvrkqlSLLNKASISTIHSFCLQVIRGYY 124
Cdd:cd17932 71 -------QLASGVWIGTFHSFALRILRRYG 93
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
790-889 |
1.80e-21 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 91.91 E-value: 1.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 790 EQEDVVRIMTIHKSKGLEFPVVFVAGLGRRFNTQDLMKRfllhkdfgfgsqfidprkrikyttlsqlaiKRKMKMELIAE 869
Cdd:cd18807 81 EEALRVTLMTIHASKGLEFPVVFIVGLGEGFIPSDASYH------------------------------AAKEDEERLEE 130
|
90 100
....*....|....*....|
gi 446494438 870 EMRVLYVALTRAKEKLILIG 889
Cdd:cd18807 131 ERRLLYVALTRAKKELYLVG 150
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
293-887 |
4.71e-20 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 96.48 E-value: 4.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 293 LKRIKKS---DYNEDIVKQVDSLRNKAKDEvkklqeelfSRRPesflRDFQDMH-PVLEKLVQLVKVFTErfqAMKRdKG 368
Cdd:PRK11773 123 LKRLIKAlnlDEKQWPPRQAQWYINGQKDE---------GLRP----QHIQSYGdPVEQTWLKIYQAYQE---ACDR-AG 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 369 MVDFTDLehfclqiLSEQSEDGEMKPSAVAlQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSeseGNLFMVGDVKQSIY 448
Cdd:PRK11773 186 LVDFAEL-------LLRAHELWLNKPHILQ-HYQERFTHILVDEFQDTNAIQYAWIRLLAGDT---GKVMIVGDDDQSIY 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 449 RFRLAEpglfLGKYKRFTQEgLGGGMKIDLAKNFRSRHEVLAGTNFIfkqimgeevgeIDYDADaelKLGasypegedva 528
Cdd:PRK11773 255 GWRGAQ----VENIQRFLND-FPGAETIRLEQNYRSTANILKAANAL-----------IANNNG---RLG---------- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 529 aellciqqtEEEVIDGEEGaevEKAQL--------EARLMAQRIKAMVDSGYEvydrktdsmrpvqYRDFVILLRSMPWA 600
Cdd:PRK11773 306 ---------KELWTDGGDG---EPISLycafneldEARFVVERIKTWQDNGGA-------------LSDCAILYRSNAQS 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 601 pQIMEELKLQ-GIP--VYADLAtgYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLR--AHGKKGSF 675
Cdd:PRK11773 361 -RVLEEALLQaGIPyrIYGGMR--FFERQEIKDALAYLRLIANRNDDAAFERVVNTPTRGIGDRTLDVVRqtARDRQLTL 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 676 YEVMSSFLkgapleEEKELHDK----LEWFYNLLQGWREFARQQSLSDLIWKVYGETGYYDFVG---GLpAGKQRQANLR 748
Cdd:PRK11773 438 WQACRALL------QEKVLAGRaasaLQRFIELIDALAQETADMPLHEQTDRVIKDSGLRAMYEqekGE-KGQARIENLE 510
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 749 VLYDRARQY----EATSFRGLFRFLRFIEriLERGDdmGTAralGEQEDVVRIMTIHKSKGLEFPVVFVAGLgrrfntqd 824
Cdd:PRK11773 511 ELVTATRQFsypdEDEDLTPLQAFLSHAA--LEAGE--GQA---DAHEDAVQLMTLHSAKGLEFPLVFIVGM-------- 575
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494438 825 lmkrfllhkdfgfgSQFIDPrkrikyttlSQLAIKRKMKMEliaEEMRVLYVALTRAKEKLIL 887
Cdd:PRK11773 576 --------------EEGLFP---------SQMSLEEGGRLE---EERRLAYVGITRAMQKLTL 612
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
534-892 |
1.32e-16 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 83.22 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 534 IQQTEEEVIDGEEgAEVEKAQL---EARLMAQRIKAMVDSGYEvydrktdsmrpvqYRDFVILLRSMPWAPQIMEELKLQ 610
Cdd:pfam13361 33 KKILAETVEDGEK-IKIIEAETeeeEAEWIALEIKKLVARDEK-------------YNDIAVLTRSNSDADLIEEALKKL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 611 GIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDeelATLRAHGKKGSFYEVMSSFLKGAPLEE 690
Cdd:pfam13361 99 GIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNGPKRGIGN---ATLERIREYKKRGLRLSDFINPDTLTY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 691 -----EKELHDKLEWFYNLLQGWR----------------------EFARQQSLSDLIWKVYGETGYYD---FVGGLPAG 740
Cdd:pfam13361 176 gdpfvIALEQDNIVVFDVETTGLDttedeiiqiaaiklnkkgvvieSFERFLRLKKPVGDSLQVHGFSDeflQENGETPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 741 KQ------RQANLRVLYDRARQYEATSFRGLFR--FLRFIERI-LERGDDMGtaralGEQEDVVRIMTIHKSKGLEFPVV 811
Cdd:pfam13361 256 EAlrdfleKLENLRELYSILREYDDIEETPEPEdaLRNFLEIAtLSNSELEG-----SDIKERIPIMTIHQAKGLEFDTV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 812 FVAGLGRRfntqdlmkrfllhkdfgfgsqfidprkrikyTTLSQLAIKRKmkmELIAEEMRVLYVALTRAKEKLILIGTV 891
Cdd:pfam13361 331 FLAGLEEG-------------------------------IFPSYRSIKDE---GNLEEERRLFYVAITRAKKRLYISYSK 376
|
.
gi 446494438 892 K 892
Cdd:pfam13361 377 S 377
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
369-886 |
3.18e-16 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 83.74 E-value: 3.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 369 MVDFTDLEHFCLQILSEQSEdgemkpsaVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKdseSEGNLFMVGDVKQSIY 448
Cdd:PRK10919 180 VLDFDDLILLPTLLLQRNEE--------VRERWQNKIRYLLVDEYQDTNTSQYELVKLLVG---SRARFTVVGDDDQSIY 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 449 RFRLAEPGLFLGKYKRFTQEGLgggmkIDLAKNFRSRHEVLAGTNF-------IFKQIMGEEVGEIDydadaELKLGASY 521
Cdd:PRK10919 249 SWRGARPQNLVLLSQDFPALQV-----IKLEQNYRSSGRILKAANIliannphVFEKRLFSELGYGD-----ELKVLSAN 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 522 PEgedvaaellciqQTEEEVIDGEegaevekaqlearLMAQRikamvdsgyevYDRKTdsmrpvQYRDFVILLRSMPWAp 601
Cdd:PRK10919 319 NE------------EHEAERVTGE-------------LIAHH-----------FVNKT------QYKDYAILYRGNHQS- 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 602 QIMEELKLQG-IPVYADLATGYFEATEVNIMMNVFRVIDNPMQDiplAAVLRspIVGLNDEEL--ATLRAHGK------- 671
Cdd:PRK10919 356 RVFEKFLMQNrIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDD---SAFLR--IVNTPKREIgpATLQKLGEwamtrnk 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 672 ---KGSFYEVMSSFLKGAPLEEekelhdkLEWFYNLLQGWREFARQQSLS---DLIWKVYGETGYYDFVGGLPAGKQRQA 745
Cdd:PRK10919 431 slfTASFDMGLSQTLSGRGYES-------LTRFTHWLAEIQRLAEREPVAavrDLIHGIDYESWLYETSPSPKAAEMRMK 503
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 746 NLRVLYD-RARQYEATSFRGLFRFLRFIER-----ILERGDDmgtaralGEQEDVVRIMTIHKSKGLEFPVVFVAGlgrr 819
Cdd:PRK10919 504 NVNQLFSwMTEMLEGSELDEPMTLTQVVTRftlrdMMERGES-------EEELDQVQLMTLHASKGLEFPYVYLVG---- 572
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446494438 820 fntqdlMKRFLLhkdfgfgsqfidPRkrikyttlsQLAIKRkmkmELIAEEMRVLYVALTRAKEKLI 886
Cdd:PRK10919 573 ------MEEGLL------------PH---------QSSIDE----DNIDEERRLAYVGITRAQKELT 608
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
556-1220 |
7.91e-16 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 83.26 E-value: 7.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 556 EARLMAQRIKAMV-DSGYEvydrktdsmrpvqYRDFVILLRSM-PWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMN 633
Cdd:COG3857 287 EVEAVAREIRRLVrEEGYR-------------YRDIAVVVRDLeAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILS 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 634 VFRVIDNPMQDIPLAAVLRSP-IVGLNDEELATL----RAHGKKGSFYEVMSSFLKGAPLEEEKELHDKL----EWFYNL 704
Cdd:COG3857 354 LLELVRSNFRYEDVFRLLKTGlLRPLSREEIDRLenyvLAYGIRGRRWLERYLEEEEELTDEEEEDLERLnelrDRLLEP 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 705 LQGWRE-FARQQSLSDLIwkvygeTGYYDFV--GGLPA--GKQRQANLRVLYDRARQYEA--TSFRGLFR---------- 767
Cdd:COG3857 434 LLPLRErLKKAKTVREWA------EALYEFLeeLGVPEklEEWREAEEAGDLEEAREHEQawNALIELLDelvevlgdek 507
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 768 -----FLRFIERILERGddmgTARALGEQEDVVRIMTIHKSKGLEFPVVFVAGLG-RRFNTQDLMKRFLLHKDfgfgsqf 841
Cdd:COG3857 508 lsleeFLRILESGLEEL----TFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNeGVFPARPREDGLLSDEE------- 576
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 842 idpRKRIKYTTLsQLAIKRKmkmELIAEEMRVLYVALTRAKEKLILI-GTVKDATKEMEkwldarehsewllpdhvraga 920
Cdd:COG3857 577 ---RERLNELGL-ELPPTSR---ERLLEERFLFYRALTRASERLYLSyPLADEEGKALL--------------------- 628
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 921 scyldwiaPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEVvdgntllapepvqeekQELLEALREKKAVPLQserkD 1000
Cdd:COG3857 629 --------PSPLIDRLRELFPELEERSLLEEELEYIGTPESAL----------------SELAAALRQLELAPLW----W 680
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1001 EVYDRLMwkygyeeatshraKQSVTEIKRNYQseegsdN---AFIKK-LRapIKTRPRFmekkGLTYAERGTAVHAVMQH 1076
Cdd:COG3857 681 DVYKWLL-------------KLSVSRLETYAA------CpfqFFLRYgLK--LKEREEY----ELDAPDRGTLFHAVLER 735
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1077 V--DLKK------PITVEVLQEQIAGMVNKEL---------------LTFEQAEEIaVEKVISFFDSDLgkRVLAAKSVE 1133
Cdd:COG3857 736 FykELKEegldwaDLSDEELEELLEEAVEELApelqngillssaryrYLLERLKRL-LKRARRWLEEEA--RRSGFEPVA 812
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1134 REVPFTMmlAAEEAYQDWQGESGESILVQGVIDcMI----EEEDGITLIDFKTdtieGKFPGGFEQAKPILEtrykVQLS 1209
Cdd:COG3857 813 LELSFGP--EGGLPPLELELPNGRKIRLRGRID-RIdrleSDGRYLRIIDYKS----GSKKFDLDDVYYGLA----LQLP 881
|
730
....*....|.
gi 446494438 1210 LYAKALEKSLQ 1220
Cdd:COG3857 882 LYLDAALENLE 892
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
30-881 |
1.90e-13 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 75.39 E-value: 1.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 30 LVAAAAGSGKT---AVLVERIIKKIINEE---NPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLI-------DEPGSQH 96
Cdd:PRK10876 21 LIEASAGTGKTftiAALYLRLLLGLGGSAafpRPLTVEEILVVTFTEAATEELRGRIRSNIHELRIaclreetDNPLYQR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 97 VRKQLS--------LL------NKASISTIHSFCLQvirgyyyMLdvdprfrIANQTENELLKEEVLddileeeygIEDN 162
Cdd:PRK10876 101 LLAEIDdkaqaaqwLLlaerqmDEAAIFTIHGFCQR-------ML-------NLNAFESGMLFEQQL---------IEDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 163 TiffELVDRYTSD---RSDDDLQRMILALHTESRAHPnpekwldklvEAydvegktiedlvyasyLLEDVKFQLETAEQH 239
Cdd:PRK10876 158 S---LLRYQACADfwrRHCYPLPREIARVVFQEWKGP----------EA----------------LLKDISRYLQGEAPV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 240 IRKATE----LAMLPDGPAPRIETLQA-------DLALLGTLSSAARESWTSVYEA--MQNVS-W---QTLkrikksDYN 302
Cdd:PRK10876 209 IKAPPPddetLASRHEQIVARIDAVKQqwreavgELDALIESSGVDRRSYNSKNLPkwLEKISaWaeeETN------SYQ 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 303 --EDIVKQVDS-LRNKAK----------DEVKKLQEELFSrrpesfLRDFqdmhpVLEKLVQLVKVFTERfqaMKRDKGM 369
Cdd:PRK10876 283 lpKELEKFSQRfLLEKTKkgetpqhplfEAIDQLLAEPLS------LRDL-----VITRALAEIRETVAQ---EKRRRGE 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 370 VDFTDLehfcLQILSE--QSEDGEMKPSAValqyRNKFAEVLVDEYQDTNFVQESIIKFVTKDSESEGnLFMVGDVKQSI 447
Cdd:PRK10876 349 LGFDDL----LSRLDSalQSEGGEALAAAI----RTRYPVAMIDEFQDTDPQQYRIFRRIYRHQPETA-LLLIGDPKQAI 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 448 YRFRLAEpgLFlgKYKRFTQEglgggmkID----LAKNFRSRHEVLAGTN---------FIFKQIMGEEVgeIDYDADAE 514
Cdd:PRK10876 420 YAFRGAD--IF--TYMKARSE-------VSahytLDTNWRSAPGMVNSVNklfsqtddpFLFREIPFIPV--KAAGKNQA 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 515 LKLgaSYpEGEDVAAELLCIQqteeevidGEEGAEV-EKAQLEARLMAQRIKAMVDSGY--EVYDRKTDSMRPVQYRDFV 591
Cdd:PRK10876 487 LRF--VV-KGETQPAMKFWLM--------EGEGVGVgDYQQTMAQQCAAQIRDWLQAGQrgEALLMNGDDSRPVRASDIT 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 592 ILLRSMPWAPQIMEELKLQGIP-VYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLRahg 670
Cdd:PRK10876 556 VLVRSRQEAALIRDALTLLAIPsVYLSNRDSVFETLEAQEMLWLLQAVLAPERERTLRSALATSMMGLDALDIDALN--- 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 671 kkgsfyevmssflkgapleeekelHDKLEW------FYNLLQGW---------REFARQQSLSDLIWKVYGetgyydfvg 735
Cdd:PRK10876 633 ------------------------NDERAWdalveeFDGYRQIWrkrgvlpmlRALMSARNIAENLLATAG--------- 679
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 736 glpaGKQRQANL----RVLYDRARQYEatSFRGLFRFLRfiERILERgddmgTARALGEQ------EDVVRIMTIHKSKG 805
Cdd:PRK10876 680 ----GERRLTDIlhigELLQEASSQLD--SEHALVRWLA--QQILEP-----DSQASSQQlrlesdKHLVQIVTIHKSKG 746
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 806 LEFPVV---FVAGlgrrFNTQDlmkRFLLHkdfgfgsqfidprKRIKYTTLSQL----AIKRKMKMELIAEEMRVLYVAL 878
Cdd:PRK10876 747 LEYPLVwlpFITN----FRVQD---QAFYH-------------DRHSFEAVLDLnaaeESVALAEEERLAEDLRLLYVAL 806
|
...
gi 446494438 879 TRA 881
Cdd:PRK10876 807 TRS 809
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
791-906 |
5.25e-08 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 57.15 E-value: 5.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 791 QEDVVRIMTIHKSKGLEFPVVFVAGLGrrfntqdlmkrfllhkDFGFGSQFIDPRkrikyttlsqlaikrkmkmeliaee 870
Cdd:COG3972 485 KDGGVTISTIHRAKGLEAPVVIIVGLD----------------QLAKGESLERLR------------------------- 523
|
90 100 110
....*....|....*....|....*....|....*....
gi 446494438 871 mRVLYVALTRAKEKLILIGTVKDA---TKEMEKWLDARE 906
Cdd:COG3972 524 -NLLYVAMTRARGWLVVSGSGESMaelYDELREVLNSTY 561
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
18-81 |
8.78e-08 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 52.22 E-value: 8.78e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446494438 18 QWKAVV--ANGRDILVAAAAGSGKTAVLVERIikKIINEENPVDvDRLLVVTFTNAAAQEMKNRIG 81
Cdd:pfam13245 1 QREAVRtaLPSKVVLLTGGPGTGKTTTIRHIV--ALLVALGGVS-FPILLAAPTGRAAKRLSERTG 63
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
1-121 |
1.69e-07 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 55.73 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1 MIENWP---KKPEGSQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEEnpVDVDRLLVVTFTNAAAQEMK 77
Cdd:PRK11054 181 MLEEYAdffSQVESSPLNPSQARAVVNGEDSLLVLAGAGSGKTSVLVARAGWLLARGQ--AQPEQILLLAFGRQAAEEMD 258
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 446494438 78 NRIGEALekvlidepGSQHVRkqlsllnkasISTIHSFCLQVIR 121
Cdd:PRK11054 259 ERIRERL--------GTEDIT----------ARTFHALALHIIQ 284
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
795-888 |
1.84e-07 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 48.72 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 795 VRIMTIHKSKGLEFPVVFVAGlgrrfntqdlmkrfllhkdfgfgsqfidprkrIKYTTLsqlaikrkmkmELIAEEMRVL 874
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVFLVD--------------------------------PDLTAH-----------YHSMLRRRLL 38
|
90
....*....|....
gi 446494438 875 YVALTRAKEKLILI 888
Cdd:pfam13538 39 YTAVTRARKKLVLV 52
|
|
| Slr0479 |
COG2887 |
RecB family exonuclease [Replication, recombination and repair]; |
1060-1229 |
2.03e-06 |
|
RecB family exonuclease [Replication, recombination and repair];
Pssm-ID: 442133 [Multi-domain] Cd Length: 248 Bit Score: 50.42 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1060 GLTYAERGTAVHAVMQHvdLKKPITVEVLQEQIAGMVNKEL--LTFEQAEEIAVEK------VISFFDSDLGKRvlAAKS 1131
Cdd:COG2887 33 PPDAADRGTLVHAVLER--FYKLPADELPAEELLALLEEAWaeLGFEDPWAAALWLeraerlLEAFLEWERAPA--GLEP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1132 VEREVPFTMMLAAEeayqdwqgesgesILVQGVIDcMIEE-EDG-ITLIDFKTdtieGKFPGGFEQAKpiletrYKVQLS 1209
Cdd:COG2887 109 VAVEVEFELELPGG-------------VRLRGRID-RIDRlPDGrLVVVDYKT----GKAPSTKDEAG------EDPQLA 164
|
170 180
....*....|....*....|..
gi 446494438 1210 LYAKALEKSLQH--PVKEKCLY 1229
Cdd:COG2887 165 LYALALERGFEGlvPAGARLVY 186
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
15-109 |
6.64e-06 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 47.62 E-value: 6.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 15 TDDQWKAV--VANGRDILVAAAAGSGKTAVLVERIIKKIINEENPVdvdRLLVVTFTNAAAQEMKNRI---GEALEKVLI 89
Cdd:pfam00270 1 TPIQAEAIpaILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGP---QALVLAPTRELAEQIYEELkklGKGLGLKVA 77
|
90 100
....*....|....*....|
gi 446494438 90 DEPGSQHVRKQLSLLNKASI 109
Cdd:pfam00270 78 SLLGGDSRKEQLEKLKGPDI 97
|
|
| PDDEXK_1 |
pfam12705 |
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ... |
1064-1241 |
1.17e-05 |
|
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily
Pssm-ID: 432731 [Multi-domain] Cd Length: 250 Bit Score: 48.30 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1064 AERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELLTFEQAEEIAVEkvISFFDSDLgkRVLAAKSVER-----EVPF 1138
Cdd:pfam12705 34 PDLGTLVHAALERFYRWGRLPEEDLEELLQALLEELWPELGLQSEILPR--LPWLAGRL--RRRLERMLRRlaewlRARR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1139 TMMLAAEEAyqdwqGESGESILVQGVIDCMIEEEDG-ITLIDFKTdtieGKFPGGFEQakpiLETRYKVQLSLYAKALEK 1217
Cdd:pfam12705 110 GFRPVAVEL-----GFGGTTVRLVGRIDRVDLDGEGyLRIIDYKT----GSAPPQSED----LDLYEGLQLLLYLLALAA 176
|
170 180
....*....|....*....|....*
gi 446494438 1218 SLQHPVKE-KCLYFFDGNHVIKVEE 1241
Cdd:pfam12705 177 GEKALGGPaGALYLRLDDPLKKDEE 201
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
30-91 |
5.65e-05 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 44.01 E-value: 5.65e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446494438 30 LVAAAAGSGKTAVLVeRIIKKIINEENpVDVDRLLVVTFTNAAAQEMKNrigealekVLIDE 91
Cdd:cd17914 3 LIQGPPGTGKTRVLV-KIVAALMQNKN-GEPGRILLVTPTNKAAAQLDN--------ILVDE 54
|
|
| Cas4 |
COG1468 |
CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; CRISPR/Cas ... |
1142-1240 |
2.77e-03 |
|
CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; CRISPR/Cas system-associated exonuclease Cas4, RecB family is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 441077 [Multi-domain] Cd Length: 184 Bit Score: 40.33 E-value: 2.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 1142 LAAEEAYQDWQGE------SGESILVQGVIDCMIEEEDGITLIDFKTdtiegkfpggfeqAKPILETRYKVQLSLYAKAL 1215
Cdd:COG1468 43 LLHERVYKRLERLrrevplDSERLGLTGKIDLVEFEDGELVPVEYKK-------------SKPKPWEADRMQLCAYALLL 109
|
90 100
....*....|....*....|....*
gi 446494438 1216 EKSLQHPVKEKCLYFFDGNHVIKVE 1240
Cdd:COG1468 110 EEMLGIPVPKGYLYYPEERKREEVE 134
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
6-130 |
2.97e-03 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 40.55 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 6 PKKPEGSQWTDDQWKAV---VANGRDILVAAAAGSGKTAVLVERIIKKIINEENPvdvdRLLVVTFTNAAAQEMKNRIGE 82
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIealLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG----RVLVLVPTRELAEQWAEELKK 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446494438 83 ALEKVLIDEP---GSQHVRKQLSLLNKAS----ISTIHSFCLQVIRGYYYMLDVD 130
Cdd:smart00487 77 LGPSLGLKVVglyGGDSKREQLRKLESGKtdilVTTPGRLLDLLENDKLSLSNVD 131
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
403-456 |
6.02e-03 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 38.24 E-value: 6.02e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 446494438 403 NKFAEVLVDEYQDTNFVQESIIKFVTKDSeseGNLFMVGDVKQSIYRFRLAEPG 456
Cdd:cd17914 45 AQLDNILVDEAAQILEPETSRLIDLALDQ---GRVILVGDHDQLGPVWRGAVLA 95
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
35-123 |
6.64e-03 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 40.59 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494438 35 AGSGKTAVLVERIIKKIINEENpvdvDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPgsqhvrkqlslLNKASISTIHS 114
Cdd:COG3972 182 AGSGKTVLLAAKAAYLALKHPG----WRILVTCFNRSLADHLRDLIPRFLRRFSNGEP-----------EDNVKLIVFHA 246
|
....*....
gi 446494438 115 FCLQVIRGY 123
Cdd:COG3972 247 WGGKLLKQY 255
|
|
| |
