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Conserved domains on  [gi|446494663|ref|WP_000572517|]
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MULTISPECIES: FadR/GntR family transcriptional regulator [Acinetobacter]

Protein Classification

FadR/GntR family transcriptional regulator( domain architecture ID 11450686)

helix-turn-helix transcriptional regulator belonging to the GntR family, which contains FadR, HutC, MocR, YtrA, AraR, PlmA, and many other subfamilies

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-227 1.03e-50

DNA-binding transcriptional regulator, FadR family [Transcription];


:

Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 164.72  E-value: 1.03e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   3 EQIQKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDFSIV 82
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  83 -----INSIHHSDLYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEhRAATNQQDVANFMLSDKKLHLAIAKATHNK 157
Cdd:COG2186   81 dplalLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALA-EMEAAADDGEAFAEADLAFHRAIAEASGNP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663 158 ALQATYEYFLNSSYQYTLELVTNKNLPDPNQQIHSELVQAIQHKSESEAMRIAESMLAPILRSLDSIKAD 227
Cdd:COG2186  160 LLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAE 229
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-227 1.03e-50

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 164.72  E-value: 1.03e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   3 EQIQKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDFSIV 82
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  83 -----INSIHHSDLYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEhRAATNQQDVANFMLSDKKLHLAIAKATHNK 157
Cdd:COG2186   81 dplalLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALA-EMEAAADDGEAFAEADLAFHRAIAEASGNP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663 158 ALQATYEYFLNSSYQYTLELVTNKNLPDPNQQIHSELVQAIQHKSESEAMRIAESMLAPILRSLDSIKAD 227
Cdd:COG2186  160 LLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAE 229
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 8-210 7.11e-20

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 85.20  E-value: 7.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   8 RSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDF----SIV- 82
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETwseqNIVq 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  83 -INSIHHSD---LYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEhraATNQQDVANFMLSDKKLHLAIAKATHNKA 158
Cdd:PRK10421  81 pLKTLMADDpdySFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFE---ATLSEDPDLASQADVRFHLAIAEASHNVV 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446494663 159 LQATYEYFLNsSYQYTLELVTNK--NLPDPNQQI---HSELVQAIQHKsESEAMRIA 210
Cdd:PRK10421 158 LLQTMRGFFD-VLQSSVKQSRQRmyLVPPVFSQLteqHQAVMDAILAG-DAEGARKA 212
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 3.76e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 78.26  E-value: 3.76e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446494663   9 SLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVR 74
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-73 2.52e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 65.33  E-value: 2.52e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446494663   10 LVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 1.02e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.05  E-value: 1.02e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663    14 VIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 18-73 1.05e-06

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 48.24  E-value: 1.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446494663   18 IRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:TIGR02325  17 IEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFV 72
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-227 1.03e-50

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 164.72  E-value: 1.03e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   3 EQIQKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDFSIV 82
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  83 -----INSIHHSDLYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEhRAATNQQDVANFMLSDKKLHLAIAKATHNK 157
Cdd:COG2186   81 dplalLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALA-EMEAAADDGEAFAEADLAFHRAIAEASGNP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663 158 ALQATYEYFLNSSYQYTLELVTNKNLPDPNQQIHSELVQAIQHKSESEAMRIAESMLAPILRSLDSIKAD 227
Cdd:COG2186  160 LLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAE 229
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
4-221 1.77e-24

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 96.53  E-value: 1.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   4 QIQKRSLVDEVIHVIRQNIKNDIWKVDEKIpTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTkndfsivi 83
Cdd:COG1802    6 PLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP-------- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  84 nsIHHSDLYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEH-RAATNQQDVANFMLSDKKLHLAIAKATHNKALQAT 162
Cdd:COG1802   77 --LSPEEIRELYEVRAALEGLAARLAAERATPADLARLRALLEElEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAEL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446494663 163 YEYFLNSSYQYTLELVTNKNLPDPNQQIHSELVQAIQHKSESEAMRIAESMLAPILRSL 221
Cdd:COG1802  155 LRRLRARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 8-210 7.11e-20

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 85.20  E-value: 7.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   8 RSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDF----SIV- 82
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETwseqNIVq 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  83 -INSIHHSD---LYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEhraATNQQDVANFMLSDKKLHLAIAKATHNKA 158
Cdd:PRK10421  81 pLKTLMADDpdySFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFE---ATLSEDPDLASQADVRFHLAIAEASHNVV 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446494663 159 LQATYEYFLNsSYQYTLELVTNK--NLPDPNQQI---HSELVQAIQHKsESEAMRIA 210
Cdd:PRK10421 158 LLQTMRGFFD-VLQSSVKQSRQRmyLVPPVFSQLteqHQAVMDAILAG-DAEGARKA 212
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 6-227 3.35e-19

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 83.28  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   6 QKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKN---DFSIV 82
Cdd:PRK09990   4 ERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNrvqDASPL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  83 IN--SIHHSDLYEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEHRAATNQQ----DVANFMLSDKKLHLAIAKATHN 156
Cdd:PRK09990  84 MHlfSSQPRTLYDLLEVRALLEGESARLAALRGTQADFVLITRRYEEMLAAHENnkeiDPIEHARLDHAFHLAICEASHN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663 157 K----ALQATYEYFLNSSYqytlelVTNKNL---PDPNQQI---HSELVQAIQHKSESEAMRIAESMLAPILRSLDSIKA 226
Cdd:PRK09990 164 PvlvhTLQSLTDLMLSSVF------ASVNNLyhrPQQKKQIdrqHARLYNAVLQRLPEQAQRAARDHIRTVRDNLREIEQ 237


                 .
gi 446494663 227 D 227
Cdd:PRK09990 238 E 238
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 3.76e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 78.26  E-value: 3.76e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446494663   9 SLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVR 74
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-159 1.56e-18

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 81.60  E-value: 1.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   1 MIEQIQKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV-RTKNDF 79
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVlDSSGSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  80 SIVINSIHHSD---LYEHVEVRCLLEIEIAKLAARHSTPED---MRDVIACLEHRAATNQQDvaNFMLSDKKLHLAIAKA 153
Cdd:PRK10225  81 NTDSPDANVCNdagPFELLQARQLLESNIAEFAALQATREDivkMRQALQLEERELASSAPG--SSESGDMQFHLAIAEA 158


                 ....*.
gi 446494663 154 THNKAL 159
Cdd:PRK10225 159 THNSML 164
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-77 1.20e-16

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 76.05  E-value: 1.20e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446494663  13 EVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKN 77
Cdd:COG2188    9 QIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPK 73
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-208 9.10e-16

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 73.52  E-value: 9.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   1 MIEQIQKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDFS 80
Cdd:PRK03837   5 RSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  81 IvINSI---------HHSDLYEHVE-VRCLLEIEIAKLAARHSTPEDMRDVIACLE-HRAATNqqDVANFMLSDKKLHLA 149
Cdd:PRK03837  85 I-IGQLsgmakdflsQSPDGLAHLKqARLFFESSLARYAAEHATDEQIALLRKALErNSQSLG--DNAAFIRSDMEFHRV 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446494663 150 IAKATHNKALQATYEYFLNSSYQYTLELVTNKNLPDPNQQIHSELVQAIQHKSESEAMR 208
Cdd:PRK03837 162 IAEIPGNPIFMAIHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADR 220
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-73 2.52e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 65.33  E-value: 2.52e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446494663   10 LVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 93-212 3.21e-14

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 66.62  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   93 EHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLE-HRAATNQQDVANFMLSDKKLHLAIAKATHNKALQATYEYFLNSSY 171
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEaLEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446494663  172 QYTLELVTNKNLPDPNQQIHSELVQAIQHKSESEAMRIAES 212
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
PRK11523 PRK11523
transcriptional regulator ExuR;
2-164 5.19e-13

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 66.41  E-value: 5.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663   2 IEQIQKRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKNDFSI 81
Cdd:PRK11523   1 MEITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  82 VINSihhSDL-------YEHVEVRCLLEIEIAKLAARHSTPEDMRDVIACLEHraaTNQQDVANFMLSDKKLHLAIAKAT 154
Cdd:PRK11523  81 QAAD---NNMefanygpFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQ---ARGEDCFRDSEWDLQFHVQVALAT 154

                        170
                 ....*....|
gi 446494663 155 HNKALQATYE 164
Cdd:PRK11523 155 QNSALAAIVE 164
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 1.02e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.05  E-value: 1.02e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663    14 VIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 90-215 2.03e-12

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 61.99  E-value: 2.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663    90 DLYEhveVRCLLEIEIAKLAARHSTPEDMRDVIACLE--HRAATNQQDVANFMLSDKKLHLAIAKATHNKALQATYEYFL 167
Cdd:smart00895   1 ELYE---VRRALEPLAARLAAERATDEDLAALEALLDamEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLR 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 446494663   168 NSSYQYtleLVTNKNLPDPNQQIHSELVQAIQHKSESEAMRIAESMLA 215
Cdd:smart00895  78 ARLRRL---RRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLE 122
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
31-159 2.34e-11

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 61.58  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446494663  31 EKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTK-----NDFSIVINSIHHSDLYEHVEVRCLLEIEI 105
Cdd:PRK09464  32 EKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSlwqsfSDPLVELLSDHPESQFDLLETRHALEGIA 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446494663 106 AKLAARHSTPEDMRDVIACLEH-RAATNQQDVANFMLSDKKLHLAIAKATHNKAL 159
Cdd:PRK09464 112 AYYAALRGTDEDFERIRECHHAiELAQQSGDLDAEANAVMQYQIAVTEAAHNVVL 166
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
18-78 1.83e-09

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 53.64  E-value: 1.83e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446494663  18 IRQNIKNDI----WKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTKND 78
Cdd:COG1725   15 IADQIKEAIasgeLKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDAR 79
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 7-74 1.91e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 50.98  E-value: 1.91e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446494663   7 KRSLVDEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVR 74
Cdd:COG1167   10 SGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
PRK11402 PRK11402
transcriptional regulator PhoB;
18-76 3.54e-07

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 49.45  E-value: 3.54e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446494663  18 IRQNIKNDI----WKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVRTK 76
Cdd:PRK11402  14 VRQRLLDDIaqgvYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQ 76
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 18-73 1.05e-06

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 48.24  E-value: 1.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446494663   18 IRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:TIGR02325  17 IEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFV 72
PRK14999 PRK14999
histidine utilization repressor; Provisional
 12-73 2.54e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 46.85  E-value: 2.54e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446494663  12 DEVIHVIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFV 73
Cdd:PRK14999  15 ETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
PRK09764 PRK09764
GntR family transcriptional regulator;
17-74 5.49e-06

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 45.97  E-value: 5.49e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446494663  17 VIRQNIKNDIWKVDEKIPTEPELVQGLGVGRNTIREAIKILEYLGVLEVKQGLGTFVR 74
Cdd:PRK09764  13 RIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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