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Conserved domains on  [gi|446495176|ref|WP_000573030|]
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MULTISPECIES: DUF4393 domain-containing protein [Streptococcus]

Protein Classification

DUF4393 domain-containing protein( domain architecture ID 10626891)

DUF4393 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abi_alpha pfam14337
Abortive infection alpha; Enterococci such as Enterococcus faecalis and Enterococcus faecium ...
 76-263 1.01e-46

Abortive infection alpha; Enterococci such as Enterococcus faecalis and Enterococcus faecium are part of the normal human gut microbiota. However they can also be a source of nosocomial infections specially in immunocompromised patients. Virulent bacteriophages, i.e., viruses that infect and obligatorily lyse bacteria might provide alternative options for combating them. Yet, bacterial resistance to phage is taking place in similar fashion to antibiotic resistance. This might be, in part due to temperate phages that are stably associated with their host. They compete for their bacterial host, in addition to repressor-dependent immunity against similar phages, some phage express genes conferring resistance to infection by more or less unrelated phages. They can encode abortive infection (Abi) mechanisms that cause an interruption of invasive phage development and a premature death of the infected bacteria. For instance, E. faecalis V583 prophage 6 confers resistance to the virulent phage Idefix infection mainly due to Abia-alpha protein. This Pfam family corresponds to Abi-alpha protein sequences which is mostly found in prophages, arguing that it is essentially a temperate phage weapon to fight against other phages.


:

Pssm-ID: 433879  Cd Length: 192  Bit Score: 154.47  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495176   76 SKNIENLQEPSLSIAGPALEASKFYLEEEELRNLFTKLIASSMDKSKNEFNHPSFIEIIKQFDKIDAQNFKIISDlyFKK 155
Cdd:pfam14337   2 KIPEENLVTPEPYIAVPALEALRYTLDEEELREMFANLLANAMDKRKKEDVHPSFVEIIKQLSPDEAKILKYLYG--NSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495176  156 GFVATGTYYTT----IIGQDKPLEHIASHVFVDNLEQNDIAiqSSSLTNLERLGLIQINYKAHVDEKEYYNILNNSFITK 231
Cdd:pfam14337  80 GIIPIIDIRLSkeniLGSKLFIKNNFSDLYLDALCYPPDKV--SAYIDNLERLGLIDIRYDLYLTDEKNYEALENHSIIK 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 446495176  232 KNSELK---EQNKRVLTNLGMITLTLFGVRFSKTC 263
Cdd:pfam14337 158 SLKEELekpEPDKKIDIEKGLIKLTDFGKEFVSAC 192
 
Name Accession Description Interval E-value
Abi_alpha pfam14337
Abortive infection alpha; Enterococci such as Enterococcus faecalis and Enterococcus faecium ...
 76-263 1.01e-46

Abortive infection alpha; Enterococci such as Enterococcus faecalis and Enterococcus faecium are part of the normal human gut microbiota. However they can also be a source of nosocomial infections specially in immunocompromised patients. Virulent bacteriophages, i.e., viruses that infect and obligatorily lyse bacteria might provide alternative options for combating them. Yet, bacterial resistance to phage is taking place in similar fashion to antibiotic resistance. This might be, in part due to temperate phages that are stably associated with their host. They compete for their bacterial host, in addition to repressor-dependent immunity against similar phages, some phage express genes conferring resistance to infection by more or less unrelated phages. They can encode abortive infection (Abi) mechanisms that cause an interruption of invasive phage development and a premature death of the infected bacteria. For instance, E. faecalis V583 prophage 6 confers resistance to the virulent phage Idefix infection mainly due to Abia-alpha protein. This Pfam family corresponds to Abi-alpha protein sequences which is mostly found in prophages, arguing that it is essentially a temperate phage weapon to fight against other phages.


Pssm-ID: 433879  Cd Length: 192  Bit Score: 154.47  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495176   76 SKNIENLQEPSLSIAGPALEASKFYLEEEELRNLFTKLIASSMDKSKNEFNHPSFIEIIKQFDKIDAQNFKIISDlyFKK 155
Cdd:pfam14337   2 KIPEENLVTPEPYIAVPALEALRYTLDEEELREMFANLLANAMDKRKKEDVHPSFVEIIKQLSPDEAKILKYLYG--NSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495176  156 GFVATGTYYTT----IIGQDKPLEHIASHVFVDNLEQNDIAiqSSSLTNLERLGLIQINYKAHVDEKEYYNILNNSFITK 231
Cdd:pfam14337  80 GIIPIIDIRLSkeniLGSKLFIKNNFSDLYLDALCYPPDKV--SAYIDNLERLGLIDIRYDLYLTDEKNYEALENHSIIK 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 446495176  232 KNSELK---EQNKRVLTNLGMITLTLFGVRFSKTC 263
Cdd:pfam14337 158 SLKEELekpEPDKKIDIEKGLIKLTDFGKEFVSAC 192
 
Name Accession Description Interval E-value
Abi_alpha pfam14337
Abortive infection alpha; Enterococci such as Enterococcus faecalis and Enterococcus faecium ...
 76-263 1.01e-46

Abortive infection alpha; Enterococci such as Enterococcus faecalis and Enterococcus faecium are part of the normal human gut microbiota. However they can also be a source of nosocomial infections specially in immunocompromised patients. Virulent bacteriophages, i.e., viruses that infect and obligatorily lyse bacteria might provide alternative options for combating them. Yet, bacterial resistance to phage is taking place in similar fashion to antibiotic resistance. This might be, in part due to temperate phages that are stably associated with their host. They compete for their bacterial host, in addition to repressor-dependent immunity against similar phages, some phage express genes conferring resistance to infection by more or less unrelated phages. They can encode abortive infection (Abi) mechanisms that cause an interruption of invasive phage development and a premature death of the infected bacteria. For instance, E. faecalis V583 prophage 6 confers resistance to the virulent phage Idefix infection mainly due to Abia-alpha protein. This Pfam family corresponds to Abi-alpha protein sequences which is mostly found in prophages, arguing that it is essentially a temperate phage weapon to fight against other phages.


Pssm-ID: 433879  Cd Length: 192  Bit Score: 154.47  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495176   76 SKNIENLQEPSLSIAGPALEASKFYLEEEELRNLFTKLIASSMDKSKNEFNHPSFIEIIKQFDKIDAQNFKIISDlyFKK 155
Cdd:pfam14337   2 KIPEENLVTPEPYIAVPALEALRYTLDEEELREMFANLLANAMDKRKKEDVHPSFVEIIKQLSPDEAKILKYLYG--NSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495176  156 GFVATGTYYTT----IIGQDKPLEHIASHVFVDNLEQNDIAiqSSSLTNLERLGLIQINYKAHVDEKEYYNILNNSFITK 231
Cdd:pfam14337  80 GIIPIIDIRLSkeniLGSKLFIKNNFSDLYLDALCYPPDKV--SAYIDNLERLGLIDIRYDLYLTDEKNYEALENHSIIK 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 446495176  232 KNSELK---EQNKRVLTNLGMITLTLFGVRFSKTC 263
Cdd:pfam14337 158 SLKEELekpEPDKKIDIEKGLIKLTDFGKEFVSAC 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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