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Conserved domains on  [gi|446495710|ref|WP_000573564|]
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MULTISPECIES: carbohydrate ABC transporter permease [Bacillus]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
11-307 1.29e-108

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 317.46  E-value: 1.29e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  11 AKVAKKKNLWSRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLFVGLENYQYLFSDPAFYKSIKST 90
Cdd:COG1175    2 TTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  91 LLFVVYTVPTSIILALFLALIANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSP 170
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 171 DWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQID 250
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495710 251 ILTHGGPNDATNLIVYSIYKEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERKV 307
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
11-307 1.29e-108

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 317.46  E-value: 1.29e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  11 AKVAKKKNLWSRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLFVGLENYQYLFSDPAFYKSIKST 90
Cdd:COG1175    2 TTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  91 LLFVVYTVPTSIILALFLALIANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSP 170
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 171 DWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQID 250
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495710 251 ILTHGGPNDATNLIVYSIYKEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERKV 307
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
31-310 6.99e-45

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 153.83  E-value: 6.99e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  31 LFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILALFLAL 110
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 111 IANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSPDwALFSVSVTTVWVNTGFAF 190
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQ-AMFLVVFASVWKQISYNF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 191 LVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISA-FQSFGQIDILTHGGPNDATNLIVYSIY 269
Cdd:PRK10561 160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTLIYKIY 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446495710 270 KEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERKVHYK 310
Cdd:PRK10561 240 REGFTGLDLSSSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ 280
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 27-247 7.03e-09

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 56.61  E-value: 7.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710   27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSFYltDIHGEanlFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILA- 105
Cdd:TIGR03262   1 LIARLLLAGMILALLLFLLLPLLALLTKSVY--DSDGD---FIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAf 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  106 LFLALIANGKVRGIGVFRV-----LFSSTMgisVAASAVIWLFlfhPSVGLFNNILASMNLpaiawltspdWALFSVSVT 180
Cdd:TIGR03262  76 AFAYALTRSRIPGKGAFRLvallpLLAPSL---LPAISLIYLF---GNQGLLKGLLGGFSI----------YGFWGIVIG 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495710  181 TVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFG 247
Cdd:TIGR03262 140 EVFYTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFG 206
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-297 3.75e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 52.67  E-value: 3.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  90 TLLFVVYTVPTSIILALFLALIANGKVRGI-GVFRVLFSSTMGISVAASAVIWLFLFhpsvglfnnilasmnLPAIAWLT 168
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILARKRGKLdRLLRRIIDLLLSLPSLVLGLLLVLLF---------------GVLLGWGI 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 169 SPDWALFSVSVTTVWVnTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQ 248
Cdd:cd06261   69 LPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFAL 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446495710 249 IDILTHGGPNDATNLIVysiykeAFVNHQFGTASAQAMVLFIFIFIATL 297
Cdd:cd06261  148 VSFLGGGEAPGPGTGLL------LIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 159-299 3.99e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  159 MNLPAIAWLTSPDWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVT 238
Cdd:pfam00528  37 ILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446495710  239 LISAFQSFGQIDILTHGGPNDATNLIVYSIYKEAFVNhqfGTASAQAMVLFIFIFIATLLQ 299
Cdd:pfam00528 117 FGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ---GPVLAAALILLLLNLLVDILQ 174
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
11-307 1.29e-108

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 317.46  E-value: 1.29e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  11 AKVAKKKNLWSRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLFVGLENYQYLFSDPAFYKSIKST 90
Cdd:COG1175    2 TTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  91 LLFVVYTVPTSIILALFLALIANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSP 170
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 171 DWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQID 250
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495710 251 ILTHGGPNDATNLIVYSIYKEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERKV 307
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
31-310 6.99e-45

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 153.83  E-value: 6.99e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  31 LFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILALFLAL 110
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 111 IANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSPDwALFSVSVTTVWVNTGFAF 190
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQ-AMFLVVFASVWKQISYNF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 191 LVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISA-FQSFGQIDILTHGGPNDATNLIVYSIY 269
Cdd:PRK10561 160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTLIYKIY 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446495710 270 KEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERKVHYK 310
Cdd:PRK10561 240 REGFTGLDLSSSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ 280
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-307 3.58e-37

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 134.45  E-value: 3.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710   1 MIEVGKLPAQAKVAKKKNLWSRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIY----YSFYLTDIHGEanlFVGLENYQY 76
Cdd:COG4209    1 MSTTAAKAKRKKKKRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIafkdYNPFKGIFGSP---WVGLKNFKF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  77 LFSDPAFYKSIKSTL----LFVVYTVPTSIILALFLALIANGKVRGigvfrvlFSSTMG-----ISVAASAVIWLFLFHP 147
Cdd:COG4209   78 LFSSPDFWRVLRNTLlislLKLVFGFPLPIILALLLNELRSKRFKK-------TVQTISylphfLSWVVVAGIVYQFLSP 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 148 SVGLFNNILASMNLPAIAWLTSPDWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPML 227
Cdd:COG4209  151 DTGLVNQLLRALGGEPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 228 SPT--LFFIVTV-TLISAfqSFGQIDILTHGGPNDATNLIVYSIYKEAFVNHQFGTASA----QAMVLFIFIFIATLLQF 300
Cdd:COG4209  231 RPTivILLILNIgNILNV--GFEQIYLLYNPLNYSTSDVIDTYVYRIGLQNGDYSYATAvglfKSVVGLILVLIANKIAK 308


                 ....*..
gi 446495710 301 KFAERKV 307
Cdd:COG4209  309 KLGEESL 315
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 21-306 2.61e-30

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 115.63  E-value: 2.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  21 SRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPT 100
Cdd:COG1176    3 AALRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIALLTTLI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 101 SIILALFLAL-IANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSvGLFNNILASMNL--PAIAWLTSPdwalFSV 177
Cdd:COG1176   83 CLLLGYPIAYfLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRN-GLLNSLLLALGLidEPLRLLYTE----FAV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 178 SVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQIDILthGGP 257
Cdd:COG1176  158 VIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALL--GGG 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 446495710 258 NdaTNLIVYSIYKEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERK 306
Cdd:COG1176  236 K--VLMIGNLIYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRR 282
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
22-306 7.73e-25

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 104.09  E-value: 7.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  22 RTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFyltdihgeanlFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTS 101
Cdd:COG1178    2 STRPRRRPRLLLLLLALLLALLVLLPLLALLLRAF-----------TDGLANFWALLSDPYLWRALGNTLLLALLVTLLS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 102 IILALFLA-LIANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSvGLFNNILASMNLPAIAWLTSPDWALFsvsvT 180
Cdd:COG1178   71 LLLGVPLAwLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPN-GLLNTLLRALFGLEPPDIYGLGGIIL----V 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 181 TVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQIDILthggpNDA 260
Cdd:COG1178  146 LVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL-----GGG 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 446495710 261 TNLIVYSIYKEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERK 306
Cdd:COG1178  221 YTTLTTAIYQAWLGDFDLGAAAALALVLLLLVLLLLLLERRLRRRR 266
malF PRK10999
maltose ABC transporter permease MalF;
68-307 7.78e-15

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 74.61  E-value: 7.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  68 FVGLENYQYLFSDPAFYKSIKS----TLLFVVYTVPTSIILALFLA-LIANGKVRGIGVFRVLFSSTMGISVAASAVIWL 142
Cdd:PRK10999 264 TIGWKNFTRVFTDEGIQKPFIAifiwTVVFSLLTVVLTVAVGMVLAcLVQWEALKGKAVYRVLLILPYAVPSFISILIFK 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 143 FLFHPSVGLFNNILASMNLPAIAWLTSPdwalFSVSVTTVWVNT--GFAFLVIL--GGLQNIDTSLYESASIDGASYLYK 218
Cdd:PRK10999 344 GLFNQSFGEINMMLSALFGIKPAWFSDP----TLAKTMILIVNTwlGYPYMMILcmGLLKAIPDDLYEASAMDGAGPFQN 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 219 LRRVTLPMLSPTLffivTVTLISA----FQSFGQIDILTHGGPN--------DATNLIVYSIYKEAFV---NHQFGTASA 283
Cdd:PRK10999 420 FFKITLPLLIKPL----TPLMIASfafnFNNFVLIQLLTNGGPDmigtttpaGYTDLLVSYTYRIAFEgggGQDFGLAAA 495

                        250       260
                 ....*....|....*....|....
gi 446495710 284 QAMVLFIFIFIATLLQFKFAERKV 307
Cdd:PRK10999 496 IATLIFLLVGALAILNLKATKMKF 519
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
20-306 1.11e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 68.26  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  20 WSRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFyltdiHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVP 99
Cdd:COG1178  278 PRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSL-----TKALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAAL 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 100 TSIILALFLA-LIANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSVGLfnnilasmnlpaiaWLTSPDWALfsvs 178
Cdd:COG1178  353 LAVLLALLLAyLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPL--------------LLYGTLAIL---- 414

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 179 vttVWVNT----GFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQIDILTH 254
Cdd:COG1178  415 ---VLAYVvrflPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRP 491

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446495710 255 GGpndaTNLIVYSIYkEAFVNHQFGTASAQAMVLFIFIFIATLLQFKFAERK 306
Cdd:COG1178  492 PG----FETLAVLIY-QLASSGRYGEAAALALLLVLVSLLPVLLLERLLGRR 538
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 27-306 8.15e-11

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 61.28  E-value: 8.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSFylTDIHGEANLFVG--LENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIIL 104
Cdd:COG1177    3 RLGRLLLRLFLALVLLFLYLPILVLVLYSF--NDSWFLTFPPEGftLRWYAELFSDPRLLDALLNSLLIALLSTLLATVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 105 ALFLAL-IANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFhPSVGLFNNilasmnlpaiawltspdwaLFSVSVTTVW 183
Cdd:COG1177   81 GTPAALaLARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLF-SALGLSGG-------------------LWGLILAHVV 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 184 VNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTlffIVTVTLISAFQSFGQIDI--LTHGGpnDAT 261
Cdd:COG1177  141 FTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPG---ILAGALLAFTLSFDEFVItlFLAGP--GVT 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446495710 262 NLIVYsIYKEAFVNHQFgTASAQAMVLFIFIFIATLLQFKFAERK 306
Cdd:COG1177  216 TLPVY-IYSMIRRGISP-EINALSTLLILLSLLLLLLAERLRRRG 258
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 37-245 9.60e-10

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 58.18  E-value: 9.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  37 ILLFSIFLFYPLFRTIYYSFyltdiHGEANLFVG----------LENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILAL 106
Cdd:COG0395   21 LILLALLFLFPLYWMVVTSF-----KPPAEIFSGppsllpseftLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 107 FLA-LIANGKVRGIGVFRVLFSSTMGISVAAsAVIWLFLFHPSVGLFNNILAsMNLPAIAWltspdwalfsVSVTTVWVN 185
Cdd:COG0395   96 LAAyALARFRFRGRKLLFLLILATLMIPGQV-LLIPLYLLFRQLGLLNTYWG-LILPYLAF----------GLPFGIFLL 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 186 TGFaflvilggLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTlffIVTVTLISAFQS 245
Cdd:COG0395  164 RQF--------FRSIPRELEEAARIDGASEFRIFWRIVLPLSKPA---LATVAIFTFIGA 212
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 27-247 7.03e-09

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 56.61  E-value: 7.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710   27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSFYltDIHGEanlFVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILA- 105
Cdd:TIGR03262   1 LIARLLLAGMILALLLFLLLPLLALLTKSVY--DSDGD---FIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAf 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  106 LFLALIANGKVRGIGVFRV-----LFSSTMgisVAASAVIWLFlfhPSVGLFNNILASMNLpaiawltspdWALFSVSVT 180
Cdd:TIGR03262  76 AFAYALTRSRIPGKGAFRLvallpLLAPSL---LPAISLIYLF---GNQGLLKGLLGGFSI----------YGFWGIVIG 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495710  181 TVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFG 247
Cdd:TIGR03262 140 EVFYTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFG 206
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 29-287 1.09e-08

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 55.39  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  29 GLLFLAPSILLFSIFLFYPLFRTIYYSfyLTDIHGeanlfVGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILALFL 108
Cdd:PRK15050  24 PLLWLLLPLLVLAPLVVYPLVRVVLQS--LTGEHG-----LGLATYRAVLGSPDFRGALLTTLQIAFASTAGCLVLGVLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 109 ALI--------ANGKVRGIGVFrVLFSSTMgISVAasaviWLFLFHpSVGLFNNILASM---NLPAIAWLTSPdwalFSV 177
Cdd:PRK15050  97 ALVlafvpfpgASLVGRFIDTF-VAFPSFL-ITLA-----FTFLYG-SAGSVNIALQRLfglEAPPLDFLYSP----GGV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 178 SVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGqidILTHGGP 257
Cdd:PRK15050 165 ILAEITFYTPFVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAAGGSLCLLLTLNEFG---IVLFTGA 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 446495710 258 NDATNLIVySIYKEAFVNHQFGTASAQAMV 287
Cdd:PRK15050 242 KDVVTLPV-LIYSKAIVDFDYPTACAIAVV 270
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-297 3.75e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 52.67  E-value: 3.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  90 TLLFVVYTVPTSIILALFLALIANGKVRGI-GVFRVLFSSTMGISVAASAVIWLFLFhpsvglfnnilasmnLPAIAWLT 168
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILARKRGKLdRLLRRIIDLLLSLPSLVLGLLLVLLF---------------GVLLGWGI 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 169 SPDWALFSVSVTTVWVnTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQ 248
Cdd:cd06261   69 LPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFAL 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446495710 249 IDILTHGGPNDATNLIVysiykeAFVNHQFGTASAQAMVLFIFIFIATL 297
Cdd:cd06261  148 VSFLGGGEAPGPGTGLL------LIFAILFPGDLGVAAAVALILLLLSL 190
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 21-243 3.89e-06

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 47.45  E-value: 3.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  21 SRTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTDIHGEANLF---VGLENYQYLFSDPAFYKSIKSTLLFVVYT 97
Cdd:COG3833    6 SRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIpenFTLENYKKLFTETPFLRWFLNSLIVAVVT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  98 VptsiILALFLALIA---------NGKVRGIGVFRVL--FSSTMgisvaasAVIWLFLFHPSVGLFNNIlasmnlpaiaw 166
Cdd:COG3833   86 A----IISVFLAALAayafsrfrfKGRKAGLLALLLLqmFPAFL-------ALVALYLLLSALGLLNTL----------- 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495710 167 ltspdWALFSVSVTTvwvNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPtlffIVTVTLISAF 243
Cdd:COG3833  144 -----LGLILVYLGG---AIPFNTWLMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKP----ILAVVALLSF 208
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 31-232 3.41e-05

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 44.36  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  31 LFLAPSILLFSIFLFYPLFRTIYYSFYLtdihgeanlfvGLENYQYLFSDPAFYKSIKSTLLFVVYTVPTSIILALFLA- 109
Cdd:COG0555   11 LTLGLTLLYLSLIVLLPLAALVLKAAGL-----------GWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAw 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710 110 LIANGKVRGIGVFRVLFSSTMGISVAASAVIWLFLFHPSvGLFNNILASMNlpaIAWLTSPdwalFSVSVTTVWVNTGFA 189
Cdd:COG0555   80 VLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPN-GWLGQLLAPLG---IKVAFTP----LGIVLAQTFVSLPFV 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446495710 190 FLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLF 232
Cdd:COG0555  152 VRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALL 194
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 159-299 3.99e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495710  159 MNLPAIAWLTSPDWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVT 238
Cdd:pfam00528  37 ILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446495710  239 LISAFQSFGQIDILTHGGPNDATNLIVYSIYKEAFVNhqfGTASAQAMVLFIFIFIATLLQ 299
Cdd:pfam00528 117 FGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ---GPVLAAALILLLLNLLVDILQ 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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