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Conserved domains on  [gi|446495807|ref|WP_000573661|]
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MULTISPECIES: response regulator transcription factor [Bacillus]

Protein Classification

response regulator transcription factor( domain architecture ID 11450879)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; similar to Staphylococcus aureus response regulator VraR

CATH:  1.10.10.10
Gene Ontology:  GO:0000160|GO:0006355|GO:0003677
PubMed:  10966457
SCOP:  3001179

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
4-118 3.33e-23

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


:

Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 89.88  E-value: 3.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETE-DIcaDVLF---DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIY 79
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEpDI--EVVGeaaDGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVL 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446495807  80 TGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKR 118
Cdd:cd17535   79 TAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
113-214 2.61e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


:

Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 68.63  E-value: 2.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807 113 IRCAKRKEVVIPLGLFRQLRIQQFSAKSLLQSEKTNELPITLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTEL 192
Cdd:COG2771   87 LLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRI 166
                         90       100
                 ....*....|....*....|..
gi 446495807 193 FNKLRVSSRVEAVEKAKSLGIL 214
Cdd:COG2771  167 YRKLGVSSRAELVALALRLGLI 188
 
Name Accession Description Interval E-value
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
4-118 3.33e-23

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 89.88  E-value: 3.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETE-DIcaDVLF---DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIY 79
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEpDI--EVVGeaaDGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVL 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446495807  80 TGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKR 118
Cdd:cd17535   79 TAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
PRK09483 PRK09483
response regulator; Provisional
1-214 3.28e-21

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 87.47  E-value: 3.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIEteDICADVLFDSA----EYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAI 76
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILE--DIKGIKVVGEAccgeDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  77 IIYTGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKRKEVVIPLGLFRQLRIQQFsaksllqsEKTNELPI-TLT 155
Cdd:PRK09483  79 IMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAQQMALSQI--------EPATENPFaSLS 150
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446495807 156 QREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGIL 214
Cdd:PRK09483 151 ERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLL 209
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-215 1.20e-17

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 75.70  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIETED---ICADVlFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILkhdpdaaii 77
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPdieVVGEA-ADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL--------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  78 iytgfdiephfnlllennisgiisktaskeqmittircakrkevviplglfrqlriqqfsaksllqsektnelpitlTQR 157
Cdd:COG2197   71 -----------------------------------------------------------------------------TPR 73
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807 158 EREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGILS 215
Cdd:COG2197   74 EREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
4-114 1.60e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 72.18  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807    4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFD 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 446495807   84 IEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
113-214 2.61e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 68.63  E-value: 2.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807 113 IRCAKRKEVVIPLGLFRQLRIQQFSAKSLLQSEKTNELPITLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTEL 192
Cdd:COG2771   87 LLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRI 166
                         90       100
                 ....*....|....*....|..
gi 446495807 193 FNKLRVSSRVEAVEKAKSLGIL 214
Cdd:COG2771  167 YRKLGVSSRAELVALALRLGLI 188
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
151-208 4.70e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 64.09  E-value: 4.70e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807   151 PITLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKA 208
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
GerE pfam00196
Bacterial regulatory proteins, luxR family;
153-208 7.62e-12

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 58.37  E-value: 7.62e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446495807  153 TLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKA 208
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
154-210 1.27e-10

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 55.23  E-value: 1.27e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807 154 LTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKS 210
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
4-56 7.57e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.17  E-value: 7.57e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 446495807     4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMP 56
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
PRK10100 PRK10100
transcriptional regulator CsgD;
154-208 7.98e-05

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 42.17  E-value: 7.98e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446495807 154 LTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKA 208
Cdd:PRK10100 156 LTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWA 210
 
Name Accession Description Interval E-value
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
4-118 3.33e-23

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 89.88  E-value: 3.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETE-DIcaDVLF---DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIY 79
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEpDI--EVVGeaaDGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVL 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446495807  80 TGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKR 118
Cdd:cd17535   79 TAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
PRK09483 PRK09483
response regulator; Provisional
1-214 3.28e-21

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 87.47  E-value: 3.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIEteDICADVLFDSA----EYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAI 76
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILE--DIKGIKVVGEAccgeDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  77 IIYTGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKRKEVVIPLGLFRQLRIQQFsaksllqsEKTNELPI-TLT 155
Cdd:PRK09483  79 IMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAQQMALSQI--------EPATENPFaSLS 150
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446495807 156 QREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGIL 214
Cdd:PRK09483 151 ERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLL 209
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
4-204 1.11e-20

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 85.85  E-value: 1.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETED---ICADVLfDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPditVVGEAS-NGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKRKEVVIPLGLFRQLriqqfsAKSLLQSEKTNELPIT-LTQRER 159
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVL------AASLRANRATTERDVNqLTPRER 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446495807 160 EILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEA 204
Cdd:PRK10651 162 DILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-215 1.20e-17

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 75.70  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIETED---ICADVlFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILkhdpdaaii 77
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPdieVVGEA-ADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL--------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  78 iytgfdiephfnlllennisgiisktaskeqmittircakrkevviplglfrqlriqqfsaksllqsektnelpitlTQR 157
Cdd:COG2197   71 -----------------------------------------------------------------------------TPR 73
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807 158 EREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGILS 215
Cdd:COG2197   74 EREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
4-114 1.60e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 72.18  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807    4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFD 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 446495807   84 IEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-204 3.01e-16

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 74.12  E-value: 3.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   3 EVLIIDDHMAVGMGTKALIETE---DICADVlFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIY 79
Cdd:PRK10403   8 QVLIVDDHPLMRRGVRQLLELDpgfEVVAEA-GDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  80 TGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKRKEvviplGLFRQlRIQQFSAKSLLQSEKTNELPItLTQRER 159
Cdd:PRK10403  87 TVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGS-----KVFSE-RVNQYLREREMFGAEEDPFSV-LTEREL 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446495807 160 EILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEA 204
Cdd:PRK10403 160 DVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAA 204
PRK15369 PRK15369
two component system response regulator;
2-214 5.78e-15

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 70.49  E-value: 5.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   2 IEVLIIDDHMAVGMGTKALIETE---DICADVLFDSAEYLSCItKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIII 78
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYpryKIVGQVDNGLEVYNACR-QLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  79 YTGFDIEPHFNLLLENNISGIISKTASKEQMITTIRC-AKRKEVVIPlglfrQLRIQQFSAksLLQSEKTNelPITLTQR 157
Cdd:PRK15369  83 LTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTvAVGKRYIDP-----ALNREAILA--LLNADDTN--PPLLTPR 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807 158 EREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGIL 214
Cdd:PRK15369 154 ERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
4-212 2.25e-14

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 68.59  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICAdVLFDSAE-YLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGF 82
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRV-ETFASAEaFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  83 -DIEP----------HFnlllennisgiISKTASKEQMITTIRCAKRKEVVIplglfRQLRIQQFSAKSLLQSektnelp 151
Cdd:COG4566   81 gDVPMavramkagavDF-----------LEKPFDDQALLDAVRRALARDRAR-----RAERARRAELRARLAS------- 137
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446495807 152 itLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLG 212
Cdd:COG4566  138 --LTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELVRLALALG 196
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
113-214 2.61e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 68.63  E-value: 2.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807 113 IRCAKRKEVVIPLGLFRQLRIQQFSAKSLLQSEKTNELPITLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTEL 192
Cdd:COG2771   87 LLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRI 166
                         90       100
                 ....*....|....*....|..
gi 446495807 193 FNKLRVSSRVEAVEKAKSLGIL 214
Cdd:COG2771  167 YRKLGVSSRAELVALALRLGLI 188
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
151-208 4.70e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 64.09  E-value: 4.70e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807   151 PITLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKA 208
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
PRK10360 PRK10360
transcriptional regulator UhpA;
1-203 8.70e-14

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 67.31  E-value: 8.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIETE-DICADVLFDSA-EYLSCITKKKYDVYLVDLFMPNLNGLEvtkgILKHDPDA-AII 77
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEpDLQVVAEFGSGrEALAGLPGRGVQVCICDISMPDISGLE----LLSQLPKGmATI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  78 IYTGFDIEPHFNLLLENNISGIISKTASKEQMITTIR------CAKRKEVVIPLGLFRQlriqqfsaksllqsektnelp 151
Cdd:PRK10360  77 MLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHtvatggCYLTPDIAIKLASGRQ--------------------- 135
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446495807 152 ITLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVE 203
Cdd:PRK10360 136 DPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVE 187
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
4-114 2.43e-13

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 64.49  E-value: 2.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHD--PDAAIIIYTG 81
Cdd:COG0784    8 ILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrlPDIPIIALTA 87
                         90       100       110
                 ....*....|....*....|....*....|...
gi 446495807  82 FDIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:COG0784   88 YADEEDRERALEAGADDYLTKPVDPEELLEALR 120
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
5-102 4.04e-13

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 63.02  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   5 LIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFDI 84
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80
                         90
                 ....*....|....*...
gi 446495807  85 EPHFNLLLENNISGIISK 102
Cdd:cd00156   81 EEDAVRALELGADDYLVK 98
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
1-119 3.59e-12

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 61.52  E-value: 3.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIETEDICADVLF--DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIII 78
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVasSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446495807  79 YTGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKRK 119
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEY 123
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
4-102 3.94e-12

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 60.56  E-value: 3.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLF--DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTG 81
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAGFEVVGEaeNGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILSG 81
                         90       100
                 ....*....|....*....|.
gi 446495807  82 FDIEPHFNLLLENNISGIISK 102
Cdd:COG4753   82 YSDFEYAQEAIKLGADDYLLK 102
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
1-114 4.95e-12

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 64.21  E-value: 4.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVE 115
GerE pfam00196
Bacterial regulatory proteins, luxR family;
153-208 7.62e-12

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 58.37  E-value: 7.62e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446495807  153 TLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKA 208
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
1-177 2.73e-11

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 60.36  E-value: 2.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTIRcakrkevviplGLFRQLRIQQFSAKSLLQSE----KTNELPITLTQ 156
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIR-----------ALLRRRAAEVLRVGDLLDLAarevTRDGEPVELTP 149
                        170       180
                 ....*....|....*....|.
gi 446495807 157 REREILIFVqqgMTNKNIALT 177
Cdd:COG0745  150 KEFRLLELL---MRNPGRVVS 167
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
4-118 1.12e-10

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 58.38  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKgILKHDPDAA---IIIYT 80
Cdd:COG3706    4 ILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCR-RLRADPRTAdipIIFLT 82
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKR 118
Cdd:COG3706   83 ALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVAR 120
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
154-210 1.27e-10

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 55.23  E-value: 1.27e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807 154 LTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKS 210
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
4-113 1.41e-10

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 56.32  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAA---IIIYT 80
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGRrtpIIALT 80
                         90       100       110
                 ....*....|....*....|....*....|...
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTI 113
Cdd:cd17546   81 ANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
fixJ PRK09390
response regulator FixJ; Provisional
4-214 2.14e-10

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 58.09  E-value: 2.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDIcADVLFDSAE-YLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGF 82
Cdd:PRK09390   6 VHVVDDDEAMRDSLAFLLDSAGF-EVRLFESAQaFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGH 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  83 DIEPhfnLLLENNISGI---ISKTASKEQMITTIRCAkrkevviplglfrqLRIQQFSAKSLLQSEKTNELPITLTQRER 159
Cdd:PRK09390  85 GDVP---LAVEAMKLGAvdfIEKPFEDERLIGAIERA--------------LAQAPEAAKSEAVAADIRARIASLSERER 147
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446495807 160 EILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGIL 214
Cdd:PRK09390 148 QVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGSLSELVRMALRAGRG 202
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
165-215 2.97e-10

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 57.41  E-value: 2.97e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446495807 165 VQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGILS 215
Cdd:COG2909  134 LAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
141-215 3.17e-10

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 54.58  E-value: 3.17e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446495807 141 LLQSEKTNELPItLTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGILS 215
Cdd:COG5905    1 MMPSSSTSHPSL-LTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLLS 74
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
5-203 4.89e-09

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 54.13  E-value: 4.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   5 LIIDDHMAVGMGTKALIETEDI-CADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFD 83
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIKNDIeILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  84 IEPHFNLLLENNISGIISKTASKEQMITTIRCAKRKEVVIPLGLFRqlriqqFSAKSLLQSEKTNelpiTLTQREREILI 163
Cdd:PRK09958  84 DHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNR------FVGSLTSDQQKLD----SLSKQEISVMR 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446495807 164 FVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVE 203
Cdd:PRK09958 154 YILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMD 193
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
3-114 5.75e-09

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 54.40  E-value: 5.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   3 EVLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKgILKHDPDAA---IIIY 79
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLR-LLRADPSTRdipVIFL 86
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446495807  80 TGFDIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:COG3437   87 TALADPEDRERALEAGADDYLTKPFDPEELLARVR 121
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
4-114 2.08e-08

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 50.73  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETED---ICADVLfDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDdleVVAQAS-NGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVT 79
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:cd19930   80 TFGRPGYFRRALAAGVDGYVLKDRPIEELADAIR 113
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
4-119 2.57e-08

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 50.41  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLF---DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELGFEVVGeaeNGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446495807  81 GFDiepHFNLL---LENNISGIISKTASKEQMITTIRCAKRK 119
Cdd:cd17536   81 GYD---DFEYAqkaIRLGVVDYLLKPVDEEELEEALEKAKEE 119
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
5-85 4.54e-08

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 49.33  E-value: 4.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   5 LIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFDI 84
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                 .
gi 446495807  85 E 85
Cdd:cd17574   81 E 81
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-82 5.17e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 52.54  E-value: 5.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAV-GMGTKALIET--EDICADvlfDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:PRK11361   7 ILIVDDEDNVrRMLSTAFALQgfETHCAN---NGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMT 83

                 ..
gi 446495807  81 GF 82
Cdd:PRK11361  84 AY 85
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
4-116 6.54e-07

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 46.57  E-value: 6.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETED---ICADVlFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPdftVVGEA-SSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILT 79
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446495807  81 GFDIEPHFNLLLENNISGIISKTASKEQMITTIRCA 116
Cdd:cd19931   80 VSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQA 115
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
1-83 8.39e-07

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 47.89  E-value: 8.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDHMAVGMGTKALIE-TEDI-CADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIII 78
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEkYPDLeVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                 ....*
gi 446495807  79 YTGFD 83
Cdd:COG3279   81 TTAYD 85
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
4-81 1.39e-06

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 45.65  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVgmgtKALIET--EDICADVL--FDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIY 79
Cdd:cd17555    3 ILVIDDDEVV----RESIAAylEDSGFQVLqaADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78

                 ..
gi 446495807  80 TG 81
Cdd:cd17555   79 SG 80
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
4-82 1.73e-06

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 45.13  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMA-VGMGTKALiETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGF 82
Cdd:cd17563    3 LLLVDDDEVfAERLARAL-ERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTGY 81
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
33-83 1.91e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 45.29  E-value: 1.91e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446495807  33 DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFD 83
Cdd:cd17554   32 NGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAYS 82
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
4-56 7.57e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.17  E-value: 7.57e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 446495807     4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMP 56
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
4-81 1.11e-05

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 43.34  E-value: 1.11e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTG 81
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITA 78
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
2-218 1.26e-05

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 44.44  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   2 IEVLIIDDHMAVGMGTKALIETEDICADV--LFDSAEYLSCITKKKYDVYLVDLFMPNL---NGLEVTKGILKHDPDAAI 76
Cdd:PRK10840   4 MNVIIADDHPIVLFGIRKSLEQIEWVNVVgeFEDSTALINNLPKLDAHVLITDLSMPGDkygDGITLIKYIKRHFPSLSI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  77 IIYTGFDIEPHFNLLLENNISGIISKTASKEQMITTIRCAKRKEVVIP---LGLFRQLRIQQFSAKSllqsektnelpit 153
Cdd:PRK10840  84 IVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPesvSRLLEKISAGGYGDKR------------- 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446495807 154 LTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGILSKIN 218
Cdd:PRK10840 151 LSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVTLSPADK 215
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
4-114 1.33e-05

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 43.04  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETED-ICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGF 82
Cdd:cd17542    3 VLIVDDAAFMRMMLKDILTKAGyEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAM 82
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446495807  83 DIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:cd17542   83 GQEEMVKEAIKAGAKDFIVKPFQPERVLEAVE 114
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
4-82 1.89e-05

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 43.75  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDI---CADvlfDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:COG4567    7 LLLVDDDEAFARVLARALERRGFevtTAA---SVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83

                 ..
gi 446495807  81 GF 82
Cdd:COG4567   84 GY 85
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
4-214 2.40e-05

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 43.71  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLF--DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTG 81
Cdd:PRK09935   6 VIIMDTHPIIRMSIEVLLQKNSELQIVLKtdDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807  82 FDIEPHFNLLLENNISGIISKTASKEQMITTIRcakrkevvIPLGLFRQLRIQQFSAKSLLQSEKTNELPITLTQREREI 161
Cdd:PRK09935  86 KSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQ--------MILSGYTFFPSETLNYIKSNKCSTNSSTDTVLSNREVTI 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446495807 162 LIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKAKSLGIL 214
Cdd:PRK09935 158 LRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
4-81 3.00e-05

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 41.71  E-value: 3.00e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTG 81
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISG 78
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
4-84 3.02e-05

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 42.09  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGF- 82
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHg 80

                 ..
gi 446495807  83 DI 84
Cdd:cd17549   81 DV 82
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
4-114 3.49e-05

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 43.02  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDI-CADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKgILKHDPDAAIIIYTGF 82
Cdd:COG3707    6 VLVVDDEPLRRADLREGLREAGYeVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAAR-QISEERPAPVILLTAY 84
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446495807  83 DIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:COG3707   85 SDPELIERALEAGVSAYLVKPLDPEDLLPALE 116
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
4-80 6.62e-05

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 40.89  E-value: 6.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLF-DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGI--LKHDPDAAIIIYT 80
Cdd:cd17551    3 ILIVDDNPTNLLLLEALLRSAGYLEVVSFtDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLraLPGLEDVPIVMIT 82
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
4-116 7.44e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 40.86  E-value: 7.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETE--DICADVLfDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPdAAIIIYTG 81
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAgyEVVGEAS-DGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLTA 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446495807  82 FDIEPHFNLLLENNISGIISKTASKEQMITTIRCA 116
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMA 115
PRK10100 PRK10100
transcriptional regulator CsgD;
154-208 7.98e-05

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 42.17  E-value: 7.98e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446495807 154 LTQREREILIFVQQGMTNKNIALTLNLSQRSIEYTLTELFNKLRVSSRVEAVEKA 208
Cdd:PRK10100 156 LTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWA 210
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
2-86 8.69e-05

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 40.60  E-value: 8.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   2 IEVLIIDDH-MAVGMGTKALIETEDIcaDVLF--DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIII 78
Cdd:cd17593    1 MKVLICDDSsMARKQLARALPADWDV--EITFaeNGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIV 78

                 ....*...
gi 446495807  79 YTGfDIEP 86
Cdd:cd17593   79 VSG-DVQP 85
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
4-83 1.43e-04

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 40.06  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGFD 83
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-80 1.55e-04

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 41.79  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   2 IEVLIIDDH-MAVGMGTKALIETEDIcaDVL---FDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPdAAII 77
Cdd:PRK12555   1 MRIGIVNDSpLAVEALRRALARDPDH--EVVwvaTDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERP-CPIL 77

                 ...
gi 446495807  78 IYT 80
Cdd:PRK12555  78 IVT 80
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
4-80 1.72e-04

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 39.98  E-value: 1.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHdPDAAIIIYT 80
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKT-SQVPVLMLT 76
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
4-114 2.69e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 39.31  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDIcaDVLF--DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTG 81
Cdd:cd17569    3 ILLVDDEPNILKALKRLLRREGY--EVLTatSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILLTG 80
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446495807  82 F-DIEPHFNLLLENNISGIISKTASKEQMITTIR 114
Cdd:cd17569   81 YaDLDAAIEAINEGEIYRFLTKPWDDEELKETIR 114
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
2-82 1.12e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 37.20  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   2 IEVLIIDDHMA-VGMGTKALIETEDI-CADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGI--LKHDPDAAII 77
Cdd:cd17561    2 IKVLIADDNREfVQLLEEYLNSQPDMeVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLrrMRLEKRPKII 81

                 ....*
gi 446495807  78 IYTGF 82
Cdd:cd17561   82 MLTAF 86
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
4-67 1.39e-03

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 37.22  E-value: 1.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKK--YDVYLVDLFMPNLNGLEVTKGI 67
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKdeFDLVITDVHMPDMDGFEFLELI 66
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
33-70 3.87e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 36.12  E-value: 3.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446495807  33 DSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKH 70
Cdd:cd17562   32 DGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKL 69
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
4-77 4.10e-03

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 35.55  E-value: 4.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807   4 VLIIDDHMAVGMGTKALIETED---ICADvlfDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKgILKHDPDAAII 77
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAEGyevLTAD---SGQEALALAEEELPDLILLDVMMPGMDGFEVCR-RLKEDPETRHI 74
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
4-80 4.58e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 35.91  E-value: 4.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGIlKHDPDAAIIIYT 80
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQI-RAESGVPIVMLT 78
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
4-80 4.64e-03

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 35.54  E-value: 4.64e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
3-80 5.28e-03

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 35.71  E-value: 5.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446495807   3 EVLIIDDHMAVG-MGTKALiETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYT 80
Cdd:cd19919    2 TVWIVDDDSSIRwVLERAL-AGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMT 79
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
3-82 5.41e-03

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 35.61  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   3 EVLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPDAAIIIYTGF 82
Cdd:cd17553    2 KILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAY 81
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
2-78 6.51e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 35.45  E-value: 6.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446495807   2 IEVLIIDD-HMAVGMGTKALIETEDI-CADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGILKHDPdAAIII 78
Cdd:cd17541    1 IRVLIVDDsAVMRKLLSRILESDPDIeVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVM 78
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
4-81 6.72e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 35.11  E-value: 6.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446495807   4 VLIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKGIlKHDPDAAIIIYTG 81
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTI-RARSDVPIIIISG 78
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
5-80 7.63e-03

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 35.33  E-value: 7.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446495807   5 LIIDDHMAVGMGTKALIETEDICADVLFDSAEYLSCITKKKYDVYLVDLFMPNLNGLEVTKgILKHDPDAA---IIIYT 80
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCR-ILRSDPKTSsipIIMLT 78
PRK11697 PRK11697
two-component system response regulator BtsR;
1-83 8.30e-03

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 36.36  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495807   1 MIEVLIIDDH-MAVGMGTKALIETEDI-----CADVLfdsaEYLSCITKKKYDVYLVDLFMPNLNGLEVTkGILkhDPDA 74
Cdd:PRK11697   1 MIKVLIVDDEpLAREELRELLQEEGDIeivgeCSNAI----EAIGAIHRLKPDVVFLDIQMPRISGLELV-GML--DPEH 73
                         90
                 ....*....|.
gi 446495807  75 --AIIIYTGFD 83
Cdd:PRK11697  74 mpYIVFVTAFD 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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