NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446495945|ref|WP_000573799|]
View 

MULTISPECIES: carbohydrate ABC transporter permease [Bacillus]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
11-307 8.46e-109

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 317.85  E-value: 8.46e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  11 TKVSKKKKLWERTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLFVGLENYQYLFSDPAFYKSIKST 90
Cdd:COG1175    2 TTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  91 LLFVLYTVPTSIIFALFLALIANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSP 170
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 171 DWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQID 250
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495945 251 ILTHGGPNDATNLIVYSIYKEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERKV 307
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
11-307 8.46e-109

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 317.85  E-value: 8.46e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  11 TKVSKKKKLWERTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLFVGLENYQYLFSDPAFYKSIKST 90
Cdd:COG1175    2 TTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  91 LLFVLYTVPTSIIFALFLALIANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSP 170
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 171 DWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQID 250
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495945 251 ILTHGGPNDATNLIVYSIYKEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERKV 307
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
31-310 1.08e-44

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 153.44  E-value: 1.08e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  31 LFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFALFLAL 110
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 111 IANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSPDwALFSVSVTTVWVNTGFAF 190
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQ-AMFLVVFASVWKQISYNF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 191 LVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISA-FQSFGQIDILTHGGPNDATNLIVYSIY 269
Cdd:PRK10561 160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTLIYKIY 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446495945 270 KEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERKVHYK 310
Cdd:PRK10561 240 REGFTGLDLSSSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ 280
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 27-247 1.73e-08

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 55.46  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945   27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSFYltNIHGEanlFVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFA- 105
Cdd:TIGR03262   1 LIARLLLAGMILALLLFLLLPLLALLTKSVY--DSDGD---FIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAf 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  106 LFLALIANGKVRGIGLFRV-----LFSSTMgisVAASAVIWLFlfhPSVGLFNNILASMNLpaiawltspdWALFSVSVT 180
Cdd:TIGR03262  76 AFAYALTRSRIPGKGAFRLvallpLLAPSL---LPAISLIYLF---GNQGLLKGLLGGFSI----------YGFWGIVIG 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495945  181 TVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFG 247
Cdd:TIGR03262 140 EVFYTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFG 206
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-293 1.82e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 53.44  E-value: 1.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  90 TLLFVLYTVPTSIIFALFLALIANGKVRGI-GLFRVLFSSTMGISVAASAVIWLFLFhpsvglfnnilasmnLPAIAWLT 168
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILARKRGKLdRLLRRIIDLLLSLPSLVLGLLLVLLF---------------GVLLGWGI 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 169 SPDWALFSVSVTTVWVnTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQ 248
Cdd:cd06261   69 LPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFAL 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446495945 249 IDILTHGGPNDATNLIVYSIYKEAFVNhqFGTASAQAMVLFVFIF 293
Cdd:cd06261  148 VSFLGGGEAPGPGTGLLLIFAILFPGD--LGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 159-299 1.60e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  159 MNLPAIAWLTSPDWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVT 238
Cdd:pfam00528  37 ILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446495945  239 LISAFQSFGQIDILTHGGPNDATNLIVYSIYKEAFVNhqfGTASAQAMVLFVFIFVATLLQ 299
Cdd:pfam00528 117 FGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ---GPVLAAALILLLLNLLVDILQ 174
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
11-307 8.46e-109

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 317.85  E-value: 8.46e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  11 TKVSKKKKLWERTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLFVGLENYQYLFSDPAFYKSIKST 90
Cdd:COG1175    2 TTTTSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  91 LLFVLYTVPTSIIFALFLALIANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSP 170
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 171 DWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQID 250
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446495945 251 ILTHGGPNDATNLIVYSIYKEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERKV 307
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
31-310 1.08e-44

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 153.44  E-value: 1.08e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  31 LFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFALFLAL 110
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 111 IANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSVGLFNNILASMNLPAIAWLTSPDwALFSVSVTTVWVNTGFAF 190
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQ-AMFLVVFASVWKQISYNF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 191 LVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISA-FQSFGQIDILTHGGPNDATNLIVYSIY 269
Cdd:PRK10561 160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTLIYKIY 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446495945 270 KEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERKVHYK 310
Cdd:PRK10561 240 REGFTGLDLSSSAAQSVVLMFLVIVLTVVQFRYVESKVRYQ 280
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-307 6.72e-37

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 134.06  E-value: 6.72e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945   1 MIEVSKLPVQTKVSKKKKLWERTKDLRIGLLFLAPSILLFSIFLFYPLFRTIY----YSFYLTNIHGEanlFVGLENYQY 76
Cdd:COG4209    1 MSTTAAKAKRKKKKRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIafkdYNPFKGIFGSP---WVGLKNFKF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  77 LFSDPAFYKSIKSTLLFVLYTV----PTSIIFALFLALIANGKVRGiglfrvlFSSTMG-----ISVAASAVIWLFLFHP 147
Cdd:COG4209   78 LFSSPDFWRVLRNTLLISLLKLvfgfPLPIILALLLNELRSKRFKK-------TVQTISylphfLSWVVVAGIVYQFLSP 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 148 SVGLFNNILASMNLPAIAWLTSPDWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPML 227
Cdd:COG4209  151 DTGLVNQLLRALGGEPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 228 SPT--LFFIVTV-TLISAfqSFGQIDILTHGGPNDATNLIVYSIYKEAFVNHQFGTASA----QAMVLFVFIFVATLLQF 300
Cdd:COG4209  231 RPTivILLILNIgNILNV--GFEQIYLLYNPLNYSTSDVIDTYVYRIGLQNGDYSYATAvglfKSVVGLILVLIANKIAK 308


                 ....*..
gi 446495945 301 KFAERKV 307
Cdd:COG4209  309 KLGEESL 315
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 27-306 1.63e-30

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 116.40  E-value: 1.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLFVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFAL 106
Cdd:COG1176    9 LRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 107 FLALI---ANGKVRGIGLFRVLFSSTMGISVAASAviWLFLFHPSvGLFNNILASMNL--PAIAWLTSPdwalFSVSVTT 181
Cdd:COG1176   89 PIAYFlarAPPRWRNLLLLLVILPFWTSFLVRTYA--WIVLLGRN-GLLNSLLLALGLidEPLRLLYTE----FAVVIGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 182 VWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQIDILthGGPNdaT 261
Cdd:COG1176  162 VYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALL--GGGK--V 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446495945 262 NLIVYSIYKEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERK 306
Cdd:COG1176  238 LMIGNLIYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRR 282
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
22-306 2.74e-25

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 105.63  E-value: 2.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  22 RTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFyltnihgeanlFVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTS 101
Cdd:COG1178    2 STRPRRRPRLLLLLLALLLALLVLLPLLALLLRAF-----------TDGLANFWALLSDPYLWRALGNTLLLALLVTLLS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 102 IIFALFLA-LIANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSvGLFNNILAsmnlpaiAWLTSPDWALFS---V 177
Cdd:COG1178   71 LLLGVPLAwLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPN-GLLNTLLR-------ALFGLEPPDIYGlggI 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 178 SVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQIDILthggp 257
Cdd:COG1178  143 ILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL----- 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 446495945 258 NDATNLIVYSIYKEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERK 306
Cdd:COG1178  218 GGGYTTLTTAIYQAWLGDFDLGAAAALALVLLLLVLLLLLLERRLRRRR 266
malF PRK10999
maltose ABC transporter permease MalF;
68-307 1.54e-13

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 70.76  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  68 FVGLENYQYLFSDPAFYKSIKS----TLLFVLYTVPTSIIFALFLA-LIANGKVRGIGLFRVLFSSTMGISVAASAVIWL 142
Cdd:PRK10999 264 TIGWKNFTRVFTDEGIQKPFIAifiwTVVFSLLTVVLTVAVGMVLAcLVQWEALKGKAVYRVLLILPYAVPSFISILIFK 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 143 FLFHPSVGLFNNILASMNLPAIAWLTSPdwalFSVSVTTVWVNT--GFAFLVIL--GGLQNIDTSLYESASIDGASYLYK 218
Cdd:PRK10999 344 GLFNQSFGEINMMLSALFGIKPAWFSDP----TLAKTMILIVNTwlGYPYMMILcmGLLKAIPDDLYEASAMDGAGPFQN 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 219 LRRVTLPMLSPTLffivTVTLISA----FQSFGQIDILTHGGPN--------DATNLIVYSIYKEAFV---NHQFGTASA 283
Cdd:PRK10999 420 FFKITLPLLIKPL----TPLMIASfafnFNNFVLIQLLTNGGPDmigtttpaGYTDLLVSYTYRIAFEgggGQDFGLAAA 495

                        250       260
                 ....*....|....*....|....
gi 446495945 284 QAMVLFVFIFVATLLQFKFAERKV 307
Cdd:PRK10999 496 IATLIFLLVGALAILNLKATKMKF 519
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
13-306 3.19e-13

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 69.80  E-value: 3.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  13 VSKKKKLWERTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFyltniHGEANLFVGLENYQYLFSDPAFYKSIKSTLL 92
Cdd:COG1178  271 VGGRARRPRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSL-----TKALDDNLTLDNYRFVLLDPSLLRALLNSLL 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  93 FVLYTVPTSIIFALFLA-LIANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSVGLfnnilasmnlpaiaWLTSPD 171
Cdd:COG1178  346 LALLAALLAVLLALLLAyLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPL--------------LLYGTL 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 172 WALfsvsvttVWVNT----GFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFG 247
Cdd:COG1178  412 AIL-------VLAYVvrflPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELS 484

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446495945 248 QIDILTHGGpndaTNLIVYSIYkEAFVNHQFGTASAQAMVLFVFIFVATLLQFKFAERK 306
Cdd:COG1178  485 ATLLLRPPG----FETLAVLIY-QLASSGRYGEAAALALLLVLVSLLPVLLLERLLGRR 538
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 27-306 1.09e-10

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 60.90  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSF----YLTNIHGEanlfVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSI 102
Cdd:COG1177    3 RLGRLLLRLFLALVLLFLYLPILVLVLYSFndswFLTFPPEG----FTLRWYAELFSDPRLLDALLNSLLIALLSTLLAT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 103 IFALFLAL-IANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFhPSVGLFNNilasmnlpaiawltspdwaLFSVSVTT 181
Cdd:COG1177   79 VLGTPAALaLARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLF-SALGLSGG-------------------LWGLILAH 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 182 VWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTlffIVTVTLISAFQSFGQIDI--LTHGGpnD 259
Cdd:COG1177  139 VVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPG---ILAGALLAFTLSFDEFVItlFLAGP--G 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 446495945 260 ATNLIVYsIYKEAFVNHQFgTASAQAMVLFVFIFVATLLQFKFAERK 306
Cdd:COG1177  214 VTTLPVY-IYSMIRRGISP-EINALSTLLILLSLLLLLLAERLRRRG 258
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 37-245 1.21e-09

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 58.18  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  37 ILLFSIFLFYPLFRTIYYSFyltniHGEANLFVG----------LENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFAL 106
Cdd:COG0395   21 LILLALLFLFPLYWMVVTSF-----KPPAEIFSGppsllpseftLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 107 FLA-LIANGKVRGIGLFRVLFSSTMGISVAAsAVIWLFLFHPSVGLFNNILAsMNLPAIAWltspdwalfsVSVTTVWVN 185
Cdd:COG0395   96 LAAyALARFRFRGRKLLFLLILATLMIPGQV-LLIPLYLLFRQLGLLNTYWG-LILPYLAF----------GLPFGIFLL 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 186 TGFaflvilggLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTlffIVTVTLISAFQS 245
Cdd:COG0395  164 RQF--------FRSIPRELEEAARIDGASEFRIFWRIVLPLSKPA---LATVAIFTFIGA 212
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 27-247 1.73e-08

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 55.46  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945   27 RIGLLFLAPSILLFSIFLFYPLFRTIYYSFYltNIHGEanlFVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFA- 105
Cdd:TIGR03262   1 LIARLLLAGMILALLLFLLLPLLALLTKSVY--DSDGD---FIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAf 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  106 LFLALIANGKVRGIGLFRV-----LFSSTMgisVAASAVIWLFlfhPSVGLFNNILASMNLpaiawltspdWALFSVSVT 180
Cdd:TIGR03262  76 AFAYALTRSRIPGKGAFRLvallpLLAPSL---LPAISLIYLF---GNQGLLKGLLGGFSI----------YGFWGIVIG 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446495945  181 TVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFG 247
Cdd:TIGR03262 140 EVFYTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFG 206
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-293 1.82e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 53.44  E-value: 1.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  90 TLLFVLYTVPTSIIFALFLALIANGKVRGI-GLFRVLFSSTMGISVAASAVIWLFLFhpsvglfnnilasmnLPAIAWLT 168
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILARKRGKLdRLLRRIIDLLLSLPSLVLGLLLVLLF---------------GVLLGWGI 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 169 SPDWALFSVSVTTVWVnTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGQ 248
Cdd:cd06261   69 LPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFAL 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446495945 249 IDILTHGGPNDATNLIVYSIYKEAFVNhqFGTASAQAMVLFVFIF 293
Cdd:cd06261  148 VSFLGGGEAPGPGTGLLLIFAILFPGD--LGVAAAVALILLLLSL 190
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 29-287 7.94e-08

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 52.70  E-value: 7.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  29 GLLFLAPSILLFSIFLFYPLFRTIYYSfyLTNIHGeanlfVGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFALFL 108
Cdd:PRK15050  24 PLLWLLLPLLVLAPLVVYPLVRVVLQS--LTGEHG-----LGLATYRAVLGSPDFRGALLTTLQIAFASTAGCLVLGVLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 109 ALIangkvrgigLFRVLFSStmgiSVAASAVIWLFLFHPS-------------VGLFNNILASM---NLPAIAWLTSPdw 172
Cdd:PRK15050  97 ALV---------LAFVPFPG----ASLVGRFIDTFVAFPSflitlaftflygsAGSVNIALQRLfglEAPPLDFLYSP-- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 173 alFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVTLISAFQSFGqidIL 252
Cdd:PRK15050 162 --GGVILAEITFYTPFVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAAGGSLCLLLTLNEFG---IV 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446495945 253 THGGPNDATNLIVySIYKEAFVNHQFGTASAQAMV 287
Cdd:PRK15050 237 LFTGAKDVVTLPV-LIYSKAIVDFDYPTACAIAVV 270
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 22-243 3.18e-06

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 47.84  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  22 RTKDLRIGLLFLAPSILLFSIFLFYPLFRTIYYSFYLTNIHGEANLF---VGLENYQYLFSDPAFYKSIKSTLLFVLYTV 98
Cdd:COG3833    7 RKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIpenFTLENYKKLFTETPFLRWFLNSLIVAVVTA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  99 ptsiIFALFLALIA-------NGKVRGIGLFRVL----FSSTMgisvaasAVIWLFLFHPSVGLFNNIlasmnlpaiawl 167
Cdd:COG3833   87 ----IISVFLAALAayafsrfRFKGRKAGLLALLllqmFPAFL-------ALVALYLLLSALGLLNTL------------ 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446495945 168 tspdWALFSVSVTTvwvNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPtlffIVTVTLISAF 243
Cdd:COG3833  144 ----LGLILVYLGG---AIPFNTWLMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKP----ILAVVALLSF 208
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 31-232 3.20e-06

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 47.44  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  31 LFLAPSILLFSIFLFYPLFRTIYYSFYLtnihgeanlfvGLENYQYLFSDPAFYKSIKSTLLFVLYTVPTSIIFALFLA- 109
Cdd:COG0555   11 LTLGLTLLYLSLIVLLPLAALVLKAAGL-----------GWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAw 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 110 LIANGKVRGIGLFRVLFSSTMGISVAASAVIWLFLFHPSvGLFNNILASMNlpaIAWLTSPdwalFSVSVTTVWVNTGFA 189
Cdd:COG0555   80 VLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPN-GWLGQLLAPLG---IKVAFTP----LGIVLAQTFVSLPFV 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446495945 190 FLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLF 232
Cdd:COG0555  152 VRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALL 194
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 159-299 1.60e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  159 MNLPAIAWLTSPDWALFSVSVTTVWVNTGFAFLVILGGLQNIDTSLYESASIDGASYLYKLRRVTLPMLSPTLFFIVTVT 238
Cdd:pfam00528  37 ILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446495945  239 LISAFQSFGQIDILTHGGPNDATNLIVYSIYKEAFVNhqfGTASAQAMVLFVFIFVATLLQ 299
Cdd:pfam00528 117 FGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ---GPVLAAALILLLLNLLVDILQ 174
cysW PRK11602
sulfate/thiosulfate ABC transporter permease CysW;
79-253 7.80e-04

sulfate/thiosulfate ABC transporter permease CysW;


Pssm-ID: 183225  Cd Length: 283  Bit Score: 40.51  E-value: 7.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945  79 SDPAFYKSIKSTLLFVLYTVPTSIIFALFLA-LIANGKVRGIGLFRVLFSSTMGISVAASAVIWLfLFHPSVGLFNNILA 157
Cdd:PRK11602  58 ADPDMLHAIWLTVLIALIAVPVNLVFGILLAwLVTRFNFPGRQLLLTLLDIPFAVSPVVAGLVYL-LFYGSNGPLGGWLD 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446495945 158 SMNLPAI-AWltsPDWALFSVSVTTVWVNTGFAFLVILGGLQNidtslYESASIDGASYLYKLRRVTLPMLSPTLFFIVT 236
Cdd:PRK11602 137 EHNLQLMfSW---PGMVLVTIFVTCPFVVRELVPVMLSQGSQE-----DEAAILLGASGWQMFRRVTLPNIRWALLYGVV 208

                        170
                 ....*....|....*..
gi 446495945 237 VTLISAFQSFGQIDILT 253
Cdd:PRK11602 209 LTNARAIGEFGAVSVVS 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH