NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446512136|ref|WP_000589591|]
View 

MULTISPECIES: VOC family protein [Bacillus]

Protein Classification

VOC family protein( domain architecture ID 10790122)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

PubMed:  21820381

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-114 1.47e-14

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


:

Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 64.27  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136   1 MIKGFGGIFWRTKNLEVIKKWYSEVLKLDIEDWNG-----TVIKPQLGNETIFSffteNDNYFPKEQQVMLNFEVHNLNE 75
Cdd:COG3324    1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAGpggdyAEFDTDGGQVGGLM----PGAEEPGGPGWLLYFAVDDLDA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446512136  76 TIKHLENIGVPLEK-KEEISEFGQFIWIKDPEGRLIELWE 114
Cdd:COG3324   77 AVARVEAAGGTVLRpPTDIPPWGRFAVFRDPEGNRFGLWQ 116
 
Name Accession Description Interval E-value
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-114 1.47e-14

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 64.27  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136   1 MIKGFGGIFWRTKNLEVIKKWYSEVLKLDIEDWNG-----TVIKPQLGNETIFSffteNDNYFPKEQQVMLNFEVHNLNE 75
Cdd:COG3324    1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAGpggdyAEFDTDGGQVGGLM----PGAEEPGGPGWLLYFAVDDLDA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446512136  76 TIKHLENIGVPLEK-KEEISEFGQFIWIKDPEGRLIELWE 114
Cdd:COG3324   77 AVARVEAAGGTVLRpPTDIPPWGRFAVFRDPEGNRFGLWQ 116
VOC_like cd07264
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 11-115 7.19e-07

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319925 [Multi-domain]  Cd Length: 118  Bit Score: 44.24  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136  11 RTKNLEVIKKWYSEVLKLDI--EDWNGTVIKpQLGNETIFSFF---TENDNYFPKEQQ--VMLNFEVHNLNETIKHLENI 83
Cdd:cd07264    7 YVDDFAASLRFYRDVLGLPPrfLHEEGEYAE-FDTGETKLALFsrkEMARSGGPDRRGsaFELGFEVDDVEATVEELVER 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446512136  84 GVPLEKKEEISEFGQFI-WIKDPEGRLIELWEK 115
Cdd:cd07264   86 GAEFVREPANKPWGQTVaYVRDPDGNLIEICEP 118
 
Name Accession Description Interval E-value
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-114 1.47e-14

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 64.27  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136   1 MIKGFGGIFWRTKNLEVIKKWYSEVLKLDIEDWNG-----TVIKPQLGNETIFSffteNDNYFPKEQQVMLNFEVHNLNE 75
Cdd:COG3324    1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAGpggdyAEFDTDGGQVGGLM----PGAEEPGGPGWLLYFAVDDLDA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446512136  76 TIKHLENIGVPLEK-KEEISEFGQFIWIKDPEGRLIELWE 114
Cdd:COG3324   77 AVARVEAAGGTVLRpPTDIPPWGRFAVFRDPEGNRFGLWQ 116
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 3-114 8.19e-12

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 57.31  E-value: 8.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136   3 KGFGGIFWRTKNLEVIKKWYSEVL------KLDIEDWNGTVIKPQLGNETIFSFFT-ENDNYFPKEQQVM-LNFEVHNLN 74
Cdd:COG0346    1 MGLHHVTLRVSDLEASLAFYTDVLglelvkRTDFGDGGFGHAFLRLGDGTELELFEaPGAAPAPGGGGLHhLAFRVDDLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446512136  75 ETIKHLENIGVPLEKKEEISEFGQ-FIWIKDPEGRLIELWE 114
Cdd:COG0346   81 AAYARLRAAGVEIEGEPRDRAYGYrSAYFRDPDGNLIELVE 121
VOC_like cd07264
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 11-115 7.19e-07

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319925 [Multi-domain]  Cd Length: 118  Bit Score: 44.24  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136  11 RTKNLEVIKKWYSEVLKLDI--EDWNGTVIKpQLGNETIFSFF---TENDNYFPKEQQ--VMLNFEVHNLNETIKHLENI 83
Cdd:cd07264    7 YVDDFAASLRFYRDVLGLPPrfLHEEGEYAE-FDTGETKLALFsrkEMARSGGPDRRGsaFELGFEVDDVEATVEELVER 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446512136  84 GVPLEKKEEISEFGQFI-WIKDPEGRLIELWEK 115
Cdd:cd07264   86 GAEFVREPANKPWGQTVaYVRDPDGNLIEICEP 118
CatE COG2514
Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];
2-112 6.33e-06

Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442004 [Multi-domain]  Cd Length: 141  Bit Score: 42.25  E-value: 6.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446512136   2 IKGFGGIFWRTKNLEVIKKWYSEVLKLDIEDWNGTVIKPQLGNETIFSFFTENDNYFPKEQQVMLN---FEVHN---LNE 75
Cdd:COG2514    1 ITRLGHVTLRVRDLERSAAFYTDVLGLEVVEREGGRVYLRADGGEHLLVLEEAPGAPPRPGAAGLDhvaFRVPSradLDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446512136  76 TIKHLENIGVPLEkkeEISEFGQF--IWIKDPEGRLIEL 112
Cdd:COG2514   81 ALARLAAAGVPVE---GAVDHGVGesLYFRDPDGNLIEL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH