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Conserved domains on  [gi|446513808|ref|WP_000591154|]
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MULTISPECIES: GntR family transcriptional regulator [Escherichia]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-246 7.23e-63

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 196.62  E-value: 7.23e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   8 SKGQLKHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSREN-HL 86
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPlSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  87 LHSFTDDIKARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDlLA 166
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPG-APVLRIERLRLADGEPVALETSYLPAALFPGLLEED-LE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808 167 TGSLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYSYKARITKD 246
Cdd:COG2188  159 TGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-246 7.23e-63

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 196.62  E-value: 7.23e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   8 SKGQLKHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSREN-HL 86
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPlSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  87 LHSFTDDIKARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDlLA 166
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPG-APVLRIERLRLADGEPVALETSYLPAALFPGLLEED-LE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808 167 TGSLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYSYKARITKD 246
Cdd:COG2188  159 TGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
PRK11402 PRK11402
transcriptional regulator PhoB;
11-239 3.57e-23

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 94.13  E-value: 3.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  11 QLKHReIFDEIKKkvdnGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVlPSRSRENHLL--H 88
Cdd:PRK11402  13 TVRQR-LLDDIAQ----GVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV-QSQKVENALLtvS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  89 SFTDDIKARGGIPAQNILEIGyVPVSDVIRKNLDLDIHVQtVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEdLLATG 168
Cdd:PRK11402  87 GFTDFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSE-VFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEI-YVEGS 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446513808 169 SLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYSY 239
Cdd:PRK11402 164 STYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-238 3.65e-23

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 91.59  E-value: 3.65e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808    96 ARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDLlaTGSLYILLE 175
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPG-DPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDL--SGSLYEYLE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446513808   176 EKLAIK---PLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYS 238
Cdd:smart00866  78 ERLGLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-238 2.48e-22

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 89.19  E-value: 2.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   96 ARGGIPAQNILEIGYVPVSDVIRKNLDLDiHVQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDLlATGSLYILLE 175
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLP-PGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDL-EEGSLYDYLE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446513808  176 EKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYS 238
Cdd:pfam07702  79 ERYGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 6-236 9.32e-21

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 87.53  E-value: 9.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808    6 KASKGQLKHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV--------L 77
Cdd:TIGR02325   2 ERTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaarridypL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   78 PSRSRenhllhsFTDDIKARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLAlNDRQ 157
Cdd:TIGR02325  82 SARTR-------FSQNLADQGREPTGELLLSDLEPASAELADALGLTVG-APLVRLETLRKADGRPLCRATTWFP-AARF 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446513808  158 EITQEDLLATGSLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASR 236
Cdd:TIGR02325 153 PGIGQAYAASGSITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-76 1.85e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 76.72  E-value: 1.85e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446513808  13 KHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV 76
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-246 7.23e-63

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 196.62  E-value: 7.23e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   8 SKGQLKHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSREN-HL 86
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPlSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  87 LHSFTDDIKARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDlLA 166
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPG-APVLRIERLRLADGEPVALETSYLPAALFPGLLEED-LE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808 167 TGSLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYSYKARITKD 246
Cdd:COG2188  159 TGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
PRK11402 PRK11402
transcriptional regulator PhoB;
11-239 3.57e-23

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 94.13  E-value: 3.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  11 QLKHReIFDEIKKkvdnGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVlPSRSRENHLL--H 88
Cdd:PRK11402  13 TVRQR-LLDDIAQ----GVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV-QSQKVENALLtvS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  89 SFTDDIKARGGIPAQNILEIGyVPVSDVIRKNLDLDIHVQtVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEdLLATG 168
Cdd:PRK11402  87 GFTDFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSE-VFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEI-YVEGS 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446513808 169 SLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYSY 239
Cdd:PRK11402 164 STYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-238 3.65e-23

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 91.59  E-value: 3.65e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808    96 ARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDLlaTGSLYILLE 175
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPG-DPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDL--SGSLYEYLE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446513808   176 EKLAIK---PLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYS 238
Cdd:smart00866  78 ERLGLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-238 2.48e-22

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 89.19  E-value: 2.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   96 ARGGIPAQNILEIGYVPVSDVIRKNLDLDiHVQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDLlATGSLYILLE 175
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLP-PGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDL-EEGSLYDYLE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446513808  176 EKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASRYS 238
Cdd:pfam07702  79 ERYGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 6-236 9.32e-21

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 87.53  E-value: 9.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808    6 KASKGQLKHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV--------L 77
Cdd:TIGR02325   2 ERTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaarridypL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   78 PSRSRenhllhsFTDDIKARGGIPAQNILEIGYVPVSDVIRKNLDLDIHvQTVFCIKRVRYMGSTPLGIQTSWLAlNDRQ 157
Cdd:TIGR02325  82 SARTR-------FSQNLADQGREPTGELLLSDLEPASAELADALGLTVG-APLVRLETLRKADGRPLCRATTWFP-AARF 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446513808  158 EITQEDLLATGSLYILLEEKLAIKPLEATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKPMEYVEMVYPASR 236
Cdd:TIGR02325 153 PGIGQAYAASGSITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-76 1.85e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 76.72  E-value: 1.85e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446513808  13 KHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV 76
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK09764 PRK09764
GntR family transcriptional regulator;
13-201 5.25e-17

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 77.56  E-value: 5.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  13 KHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSREN-HLLHSFT 91
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDiFQLTSFD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  92 DDIKARGGIPAQNILEIGYVPVSDVIRKNLDLDiHVQTVFCIKRVRYMGSTPLGIQTSWLALNDRQEITQEDLLATGSLY 171
Cdd:PRK09764  86 EKLSDRHVDTHSEVLIFEVIPADDFLQQQLQIT-AQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHF 164

                        170       180       190
                 ....*....|....*....|....*....|
gi 446513808 172 ILLEEKLAIKPLEaTEIISARLPSPLERQL 201
Cdd:PRK09764 165 IEEVKKMVIDRSE-QEIIPLMPTEEMSRLL 193
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
14-78 1.83e-14

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 70.35  E-value: 1.83e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446513808  14 HREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLP 78
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-76 3.05e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 62.63  E-value: 3.05e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446513808   15 REIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV 76
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-76 6.35e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 59.13  E-value: 6.35e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808    17 IFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV 76
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-82 5.18e-11

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 61.77  E-value: 5.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   1 MIKIYKASKGQLkHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSR 80
Cdd:COG1167    2 LIRLDRDSSGPL-YLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80


                 ..
gi 446513808  81 SR 82
Cdd:COG1167   81 PA 82
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
17-108 5.58e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 58.27  E-value: 5.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  17 IFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLP-----SRSRENHLLHSFT 91
Cdd:COG1725   15 IADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEdarelLEERREEFLEEAL 94

                         90       100
                 ....*....|....*....|
gi 446513808  92 DDIKARG---GIPAQNILEI 108
Cdd:COG1725   95 RELVAEArrlGLSLEELLEL 114
PRK14999 PRK14999
histidine utilization repressor; Provisional
 20-244 6.36e-08

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 51.86  E-value: 6.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  20 EIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSRENHL-LHSFTDDIKARG 98
Cdd:PRK14999  20 DICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFeVRSIAEEIAARR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  99 GIPAQNILEIGYVPVSDVIRKNLDLDiHVQTVFCIKRVRYMGSTPLGIQTSWL-ALNDRQEITQEDLLATGSLYILLeek 177
Cdd:PRK14999 100 HQHRCEVLTLERVRANAIQASALNVN-ESDVIFHSIMVHYENDLPVQIEDRCVnADIAVDYLTQDYRQTTPHAYLSR--- 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446513808 178 laIKPL-EATEIISARLPSPLERQLLELTADDVVLSCTRVTLSVERKpMEYVEMVYPASRYSYKARIT 244
Cdd:PRK14999 176 --IAPLtEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRI-VSHARLLFPGSRYRLQGRFI 240
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 28-227 1.38e-07

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 50.93  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808  28 GEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLpsRSRENHLLHS---FTDDIKARGGIPAQN 104
Cdd:PRK10079  27 QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVL--MRPYDYPLNAqarFSQNLLDQGSHPTSE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808 105 ILEIGYVPVSDVIRKNLDLD-----IHVQTvfcikrVRYMGSTPLGIQTSWLALNDRQEITQEdlLATGSLYILLEEKLA 179
Cdd:PRK10079 105 KLLSVLRPASGHVADALGITegenvIHLRT------LRRVNGVALCLIDHYFADLTWWPTLQR--FDSGSLHDFLREQLG 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446513808 180 IkPLEATEI-ISARLPSPLERQLLELTADDVVLsCTRvTLSV---ERKPMEY 227
Cdd:PRK10079 177 I-ALRRSQTrISARRAQAKESQLLEIPNMSPLL-CVR-TLNHrdgESSPAEY 225
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-79 3.64e-07

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 49.64  E-value: 3.64e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446513808  16 EIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVL-PS 79
Cdd:PRK03837  17 EVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSrPS 81
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 21-89 4.50e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 46.68  E-value: 4.50e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446513808  21 IKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV-----LPSRSRENHLLHS 89
Cdd:PRK09990  16 IERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVarlnrVQDASPLMHLFSS 89
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
33-94 3.26e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 43.86  E-value: 3.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446513808  33 GKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVlpsrsrENHLLHSFTDDI 94
Cdd:PRK09464  31 GEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV------QSSLWQSFSDPL 86
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 31-76 6.08e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.22  E-value: 6.08e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446513808  31 KEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFV 76
Cdd:PRK10421  21 EAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK11523 PRK11523
transcriptional regulator ExuR;
20-82 9.65e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 42.52  E-value: 9.65e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446513808  20 EIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSR 82
Cdd:PRK11523  16 ELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPR 78
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-78 3.14e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 40.68  E-value: 3.14e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446513808   1 MIKIYKASKGQLKHReIFDEIKKKVDNGEWKEGKAIpTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLP 78
Cdd:COG1802    1 MTSPSPLRRESLAEQ-VYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK10225 PRK10225
Uxu operon transcriptional regulator;
4-84 7.37e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 40.00  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446513808   4 IYKASKGQLKHREIFDEIKKKVDNGEWKEGKAIPTERELSEYYLSSRTTIRKAIESLKQRGYLHSVHGQGTFVLPSRSRE 83
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80


                 .
gi 446513808  84 N 84
Cdd:PRK10225  81 N 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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