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Conserved domains on  [gi|446521361|ref|WP_000598707|]
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MULTISPECIES: response regulator transcription factor [Bacillus]

Protein Classification

transcriptional regulator( domain architecture ID 1003377)

transcriptional regulator may belong to the NarL family and contain a C-terminal helix-turn-helix DNA-binding domain and an N-terminal REC domain, thereby functioning as a response regulator

Gene Ontology:  GO:0003677|GO:0006355|GO:0000160
PubMed:  16740923

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10651 super family cl32550
transcriptional regulator NarL; Provisional
 4-207 1.79e-51

transcriptional regulator NarL; Provisional


The actual alignment was detected with superfamily member PRK10651:

Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 165.20  E-value: 1.79e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKMMSRMRQKKEQPLHDD--LTEREFEILLLIA 161
Cdd:PRK10651  89 SNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVnqLTPRERDILKLIA 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446521361 162 EGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQ 207
Cdd:PRK10651 169 QGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQER 214
 
Name Accession Description Interval E-value
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-207 1.79e-51

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 165.20  E-value: 1.79e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKMMSRMRQKKEQPLHDD--LTEREFEILLLIA 161
Cdd:PRK10651  89 SNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVnqLTPRERDILKLIA 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446521361 162 EGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQ 207
Cdd:PRK10651 169 QGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQER 214
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-208 6.08e-49

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 155.82  E-value: 6.08e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIiqewpeakivv 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  81 vtsflddeklypvieagatsyllktsrasdiadavratydgetvlepkvtgkmmsrmrqkkeqplhddLTEREFEILLLI 160
Cdd:COG2197   70 --------------------------------------------------------------------LTPREREVLRLL 81

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446521361 161 AEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:COG2197   82 AEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGL 129
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-119 2.87e-48

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 153.82  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATY 119
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-203 1.38e-25

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 94.13  E-value: 1.38e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446521361   146 HDDLTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYA 203
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-116 5.34e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 83.74  E-value: 5.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361    4 VLLVDDHEMVRMGVSAYLsTQPDIeVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446521361   84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 2-104 1.24e-12

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 64.81  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361    2 IKVLLVDDH-EMVRMgVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI--IQEWPEAKI 78
Cdd:TIGR02875   3 IRIVIADDNkEFCNL-LKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLneIELSARPRV 81

                          90       100
                  ....*....|....*....|....*.
gi 446521361   79 VVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:TIGR02875  82 IMLSAFGQEKITQRAVALGADYYVLK 107
 
Name Accession Description Interval E-value
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-207 1.79e-51

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 165.20  E-value: 1.79e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKMMSRMRQKKEQPLHDD--LTEREFEILLLIA 161
Cdd:PRK10651  89 SNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVnqLTPRERDILKLIA 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446521361 162 EGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQ 207
Cdd:PRK10651 169 QGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQER 214
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-208 6.08e-49

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 155.82  E-value: 6.08e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIiqewpeakivv 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  81 vtsflddeklypvieagatsyllktsrasdiadavratydgetvlepkvtgkmmsrmrqkkeqplhddLTEREFEILLLI 160
Cdd:COG2197   70 --------------------------------------------------------------------LTPREREVLRLL 81

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446521361 161 AEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:COG2197   82 AEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGL 129
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-119 2.87e-48

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 153.82  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATY 119
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
PRK15369 PRK15369
two component system response regulator;
2-205 1.22e-44

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 147.53  E-value: 1.22e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKMMSRMRQKKEQPlHDDLTEREFEILLLIA 161
Cdd:PRK15369  84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALLNADDTN-PPLLTPRERQILKLIT 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446521361 162 EGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFR 205
Cdd:PRK15369 163 EGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARR 206
PRK09483 PRK09483
response regulator; Provisional
 1-208 6.96e-42

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 141.01  E-value: 6.96e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVV 80
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKM-MSRMRQKKEQPLhDDLTEREFEILLL 159
Cdd:PRK09483  81 LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAQQMaLSQIEPATENPF-ASLSERELQIMLM 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446521361 160 IAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:PRK09483 160 ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGL 208
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-201 2.07e-39

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 134.59  E-value: 2.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:PRK10403   8 QVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKMMSRMRQKKEQPLHDDLTEREFEILLLIAE 162
Cdd:PRK10403  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDPFSVLTERELDVLHELAQ 167

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 446521361 163 GKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVI 201
Cdd:PRK10403 168 GLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATI 206
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-104 2.26e-30

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 107.55  E-value: 2.26e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|..
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLK 104
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLK 102
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 2-106 1.70e-27

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 100.93  E-value: 1.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPeAKIVVV 81
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVMV 79

                         90       100
                 ....*....|....*....|....*..
gi 446521361  82 TSFLDD--EKLYPVIEAGATSYLLKTS 106
Cdd:cd17541   80 SSLTEEgaEITLEALELGAVDFIAKPS 106
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 137-208 6.91e-27

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 97.72  E-value: 6.91e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446521361 137 MRQKKEQPLHDDLTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:COG5905    1 MMPSSSTSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGL 72
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-116 1.18e-25

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 95.87  E-value: 1.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLS-TQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDwEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALE 114
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 146-203 1.38e-25

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 94.13  E-value: 1.38e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446521361   146 HDDLTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYA 203
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-116 1.82e-25

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 95.49  E-value: 1.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:cd19931   81 SDAEDDVVTALRAGADGYLLKDMEPEDLLEALK 113
PRK10360 PRK10360
transcriptional regulator UhpA;
1-195 8.30e-25

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 96.20  E-value: 8.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKgselALQLRP----DIILMDLVMDEMDGVEatraIIQEWPEA 76
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGRE----ALAGLPgrgvQVCICDISMPDISGLE----LLSQLPKG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  77 KIVVVTSFLDDEKLYP-VIEAGATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKMMSRMRqkkeqplhDDLTEREFE 155
Cdd:PRK10360  73 MATIMLSVHDSPALVEqALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQ--------DPLTKRERQ 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446521361 156 ILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSD 195
Cdd:PRK10360 145 VAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSN 184
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-117 1.44e-24

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 93.88  E-value: 1.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVV 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRA 117
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALER 119
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-116 6.97e-24

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 91.56  E-value: 6.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIR 113
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 2-116 1.03e-23

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 90.80  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQpDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKA-GYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:cd17542   80 SAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVE 114
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-116 1.30e-23

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 91.07  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI--IQEWPEAKI 78
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIraLPRLPDIPI 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446521361  79 VVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALR 120
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 149-205 3.70e-23

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 87.59  E-value: 3.70e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446521361 149 LTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFR 205
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-191 6.05e-22

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 88.86  E-value: 6.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVV 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALERE-GYEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRA--TYDGETVLEPKVTGKMMSRMRQKKEQPLHddLTEREFEILL 158
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRAllRRRAAEVLRVGDLLDLAAREVTRDGEPVE--LTPKEFRLLE 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 446521361 159 LIAEGK----SNQEIADEL----FIALKTVKTHVSNILNKL 191
Cdd:COG0745  157 LLMRNPgrvvSREQLLEEVwgydYGDDRTVDVHISRLRKKL 197
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-116 9.78e-22

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 89.11  E-value: 9.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVV 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446521361  81 VTSFldDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:COG3279   81 TTAY--DEYALEAFEVNAVDYLLKPIDEERLAKALE 114
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-116 5.34e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 83.74  E-value: 5.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361    4 VLLVDDHEMVRMGVSAYLsTQPDIeVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446521361   84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-83 7.33e-21

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 88.67  E-value: 7.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPeAKIVV 80
Cdd:PRK00742   3 KIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRP-TPVVM 81


                 ...
gi 446521361  81 VTS 83
Cdd:PRK00742  82 VSS 84
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-98 1.09e-20

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 88.01  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAkIVVV 81
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERPCP-ILIV 79

                         90
                 ....*....|....*....
gi 446521361  82 TSFLDD--EKLYPVIEAGA 98
Cdd:PRK12555  80 TSLTERnaSRVFEAMGAGA 98
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
4-208 1.37e-20

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 85.31  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELaLQLRP-DIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:PRK09935   6 VIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDY-LRTRPvDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  83 SflDDEKLYP--VIEAGATSYLLKTSRASDIADAVRATYDGETVLePKVTGKMMSRMRQKKEQPLHDDLTEREFEILLLI 160
Cdd:PRK09935  85 S--KSECFYAgrAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFF-PSETLNYIKSNKCSTNSSTDTVLSNREVTILRYL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446521361 161 AEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:PRK09935 162 VSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHEL 209
GerE pfam00196
Bacterial regulatory proteins, luxR family;
149-203 2.67e-20

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 80.32  E-value: 2.67e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446521361  149 LTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYA 203
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-194 8.47e-20

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 82.84  E-value: 8.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQpDIEVVGeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESA-GLRVET-FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  84 FLDdeklypV------IEAGATSYLLKTSRASDIADAVRA--TYDGETVLEpkvtgkmmsRMRQKKEQPLHDDLTEREFE 155
Cdd:COG4566   80 HGD------VpmavraMKAGAVDFLEKPFDDQALLDAVRRalARDRARRAE---------RARRAELRARLASLTPRERE 144

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 446521361 156 ILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVS 194
Cdd:COG4566  145 VLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGAR 183
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-115 1.11e-19

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 80.54  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQpDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPeAKIVVV 81
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEA-GYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLL 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLKTSRASDIADAV 115
Cdd:cd19932   79 TAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAI 112
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-150 1.50e-19

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 81.88  E-value: 1.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLStQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI--IQEWPEAKI 78
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLE-AAGYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLraDPRTADIPI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  79 VVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAV--RATYDGE--TVLEPKVTG----KMMSRMRQKKEQPLHDDLT 150
Cdd:COG3706   79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVdlVARYGGEefAILLPGTDLegalAVAERIREAVAELPSLRVT 158
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-104 4.55e-19

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 78.42  E-value: 4.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   5 LLVDDHEMVRMGVSAYLSTQPdiEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSF 84
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78

                         90       100
                 ....*....|....*....|
gi 446521361  85 LDDEKLYPVIEAGATSYLLK 104
Cdd:cd00156   79 ADEEDAVRALELGADDYLVK 98
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 3-147 9.25e-19

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 80.98  E-value: 9.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI--IQEWPEAKIVV 80
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTL-GYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLraDPSTRDIPVIF 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRatydgeTVLEPKVTGKMMSRMRQKKEQ--PLHD 147
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVR------NALELRRLQRELDDLVLYLKLaaPLHD 148
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
135-208 1.47e-18

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 79.80  E-value: 1.47e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446521361 135 SRMRQKKEQPLHDDLTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:COG2771  114 LLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGL 187
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-116 2.58e-18

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 81.93  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLStQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVV 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLE-RAGYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVIL 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVE 115
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-104 3.38e-16

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 71.46  E-value: 3.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV- 81
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDS-GFQVL-QAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVs 79

                         90       100
                 ....*....|....*....|....*..
gi 446521361  82 -TSFLDDeklypVIEA---GATSYLLK 104
Cdd:cd17555   80 gAGVMSD-----AVEAlrlGAWDYLTK 101
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-116 4.76e-16

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 73.07  E-value: 4.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLsTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEwPEAKIVV 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGL-REAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEE-RPAPVIL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALE 116
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
159-208 1.09e-15

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 71.66  E-value: 1.09e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446521361 159 LIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQL 208
Cdd:COG2909  133 LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGL 182
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 4-116 1.47e-15

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 69.87  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446521361  84 FldDEklYPV--IEAGATSYLLKTSRASDIADAVR 116
Cdd:cd17532   81 Y--DE--YAVeaFELNAVDYLLKPFSEERLAEALA 111
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 2-104 1.79e-15

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 69.17  E-value: 1.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDH-EMVRMgVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQE--WPEAKI 78
Cdd:cd17561    2 IKVLIADDNrEFVQL-LEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMrlEKRPKI 80

                         90       100
                 ....*....|....*....|....*.
gi 446521361  79 VVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17561   81 IMLTAFGQEDITQRAVELGASYYILK 106
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
5-209 2.86e-15

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 71.08  E-value: 2.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   5 LLVDDHEMVRMGVSAYLSTQpDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSf 84
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIKN-DIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSA- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  85 lDDEKLYP--VIEAGATSYLLKTSRASDIADAVRATYDGETV----LEPKVTGKMMSRMRQkkeqplhDDLTEREFEILL 158
Cdd:PRK09958  82 -KNDHFYGkhCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYfpfsLNRFVGSLTSDQQKL-------DSLSKQEISVMR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446521361 159 LIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRHQLT 209
Cdd:PRK09958 154 YILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 204
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-104 6.18e-15

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 68.24  E-value: 6.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQPDIEVVGeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAK--IVV 80
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVS-FTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDvpIVM 80

                         90       100
                 ....*....|....*....|....
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17551   81 ITADTDREVRLRALEAGATDFLTK 104
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-104 7.12e-15

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 67.88  E-value: 7.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQ---EWPEAKIVV 80
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKL-GYEVD-VAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRElegGGRRTPIIA 78

                         90       100
                 ....*....|....*....|....
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17546   79 LTANALEEDREKCLEAGMDDYLSK 102
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 1-116 4.95e-14

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 65.59  E-value: 4.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVV 80
Cdd:COG5803    2 MKKILIVDDQAGIRMLLKEVLKKE-GYEVF-QAANGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVIM 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:COG5803   80 MTAYGELDMVEEAKELGAKGYFTKPFDIDELREAVN 115
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-104 6.32e-14

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 64.83  E-value: 6.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI--IQEWPEAKIVV 80
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAE-GYEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLkeDPETRHIPVIM 78

                         90       100
                 ....*....|....*....|....
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17538   79 ITALDDREDRIRGLEAGADDFLSK 102
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 3-104 2.08e-13

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 64.10  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRaIIQEWPEAK---IV 79
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESA-GYEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATR-LLKEDPATRdipVI 77

                         90       100
                 ....*....|....*....|....*...
gi 446521361  80 VVTSFL---DDEKlypVIEAGATSYLLK 104
Cdd:cd17548   78 ALTAYAmkgDREK---ILEAGCDGYISK 102
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
149-203 3.21e-13

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 67.66  E-value: 3.21e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446521361 149 LTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYA 203
Cdd:PRK04841 839 LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHA 893
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-104 6.51e-13

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 66.80  E-value: 6.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQ-GFETH-CANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMT 83

                         90       100
                 ....*....|....*....|..
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLK 104
Cdd:PRK11361  84 AYAEVETAVEALRCGAFDYVIK 105
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-104 1.04e-12

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 62.04  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLStQPDIEVVGEAENGRKGSELALQLRPDIILMDLVM-DEMDGVEATRAIIQEWPeAKIVV 80
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILE-SLGYEVVGIADSGEEAIELAEENKPDLILMDINLkGDMDGIEAAREIREKFD-IPVIF 78

                         90       100
                 ....*....|....*....|....
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17534   79 LTAYSDEETLERAKETNPYGYLVK 102
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 2-104 1.24e-12

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 64.81  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361    2 IKVLLVDDH-EMVRMgVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI--IQEWPEAKI 78
Cdd:TIGR02875   3 IRIVIADDNkEFCNL-LKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLneIELSARPRV 81

                          90       100
                  ....*....|....*....|....*.
gi 446521361   79 VVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:TIGR02875  82 IMLSAFGQEKITQRAVALGADYYVLK 107
PRK10100 PRK10100
transcriptional regulator CsgD;
149-206 1.93e-12

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 63.74  E-value: 1.93e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446521361 149 LTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFRH 206
Cdd:PRK10100 156 LTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDN 213
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 2-104 5.57e-12

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 60.24  E-value: 5.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd17593    1 MKVLICDDSSMARKQLARALPADWDVEIT-FAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVV 79

                         90       100
                 ....*....|....*....|...
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17593   80 SGDVQPEAKERVLELGALAFLKK 102
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 2-195 1.26e-11

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 61.39  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVM--DEM-DGVEATRAIIQEWPEAKI 78
Cdd:PRK10840   4 MNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMpgDKYgDGITLIKYIKRHFPSLSI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  79 VVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGEtvlepKVTGKMMSRMRQKKEQPLHDD--LTEREFEI 156
Cdd:PRK10840  84 IVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGK-----KFTPESVSRLLEKISAGGYGDkrLSPKESEV 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 446521361 157 LLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSD 195
Cdd:PRK10840 159 LRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVEN 197
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-142 5.00e-11

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 59.16  E-value: 5.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVGeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERR-GFEVTT-AASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEPkvtgKMMSRMRQKKE 142
Cdd:COG4567   84 GYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPPE----NPMSLDRLEWE 139
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-104 7.42e-11

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 56.79  E-value: 7.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPdiEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAKIVVVTS 83
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHG--YRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRR-LREWSAVPVIVLSA 77

                         90       100
                 ....*....|....*....|.
gi 446521361  84 FLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17620   78 RDEESDKIAALDAGADDYLTK 98
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-104 9.57e-11

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 56.26  E-value: 9.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   5 LLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSf 84
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKE-GYEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTA- 77

                         90       100
                 ....*....|....*....|..
gi 446521361  85 LDDE--KLYpVIEAGATSYLLK 104
Cdd:cd17574   78 KDEEedKVL-GLELGADDYITK 98
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 3-104 1.11e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 54.23  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLsTQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAK---IV 79
Cdd:cd17562    2 KILAVDDSASIRQMVSFTL-RGAGYEVV-EAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKE-LRKLPAYKftpIL 78

                         90       100
                 ....*....|....*....|....*
gi 446521361  80 VVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17562   79 MLTTESSDEKKQEGKAAGATGWLVK 103
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-57 1.23e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 52.19  E-value: 1.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 446521361     2 IKVLLVDDHEMVRMGVSAYLSTQPDieVVGEAENGRKGSELALQLRPDIILMDLVM 57
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGY--EVDEATDGEEALELLKEEKPDLILLDIMM 54
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-104 1.39e-09

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 53.79  E-value: 1.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100
                 ....*....|....*....|...
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIK 103
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 3-88 5.50e-09

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 51.73  E-value: 5.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLstQPDIEVVGEAENGRKGSELALQLRP-DIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd18160    1 TILLADDEPSVRKFIVTTL--KKAGYAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILFI 78


                 ....*..
gi 446521361  82 TSFLDDE 88
Cdd:cd18160   79 SGGAAAA 85
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 4-104 7.52e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 51.36  E-value: 7.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQP-DIEVvgeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI-----IQEWPeak 77
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGyRVLV---ATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLkadpaTRHIP--- 74

                         90       100
                 ....*....|....*....|....*..
gi 446521361  78 IVVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd19920   75 VIFLTALTDTEDKVKGFELGAVDYITK 101
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 6-88 8.16e-09

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 51.50  E-value: 8.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   6 LVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSFL 85
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQVS 82


                 ...
gi 446521361  86 DDE 88
Cdd:cd17565   83 DKE 85
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 3-81 1.35e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 51.01  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVeATRAIIQEWPEAK-IVVV 81
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLAGWEVL-TASSGQEGLEKAATEQPDAILLDVMMPDMDGL-ATLKKLQANPETQsIPVI 80
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 3-116 1.92e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 50.68  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVGeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDE-GYEVVT-AGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICT 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446521361  83 SFLDDEKLYPVIEAGAtsYLLKTSRASDIADAVR 116
Cdd:cd17554   80 AYSEYKSDFSSWAADA--YVVKSSDLTELKETIK 111
PRK11697 PRK11697
two-component system response regulator BtsR;
1-104 2.83e-08

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 52.16  E-value: 2.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATrAIIQewPEA--KI 78
Cdd:PRK11697   1 MIKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELV-GMLD--PEHmpYI 77

                         90       100
                 ....*....|....*....|....*.
gi 446521361  79 VVVTSFldDEKLYPVIEAGATSYLLK 104
Cdd:PRK11697  78 VFVTAF--DEYAIKAFEEHAFDYLLK 101
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 2-74 5.67e-08

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 49.44  E-value: 5.67e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELaLQLRPDI--ILMDLVMDEMDGVEATRAIIQEWP 74
Cdd:cd17544    1 IKVLVVDDSATSRNHLRALLRRH-NFQVL-EAANGQEALEV-LEQHPDIklVITDYNMPEMDGFELVREIRKKYS 72
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 2-104 9.94e-08

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 48.94  E-value: 9.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPDIEVvGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAK---I 78
Cdd:cd17575    1 IMVLLVDDQAIIGEAVRRALADEEDIDF-HYCSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRF-FRANPATRdipI 78

                         90       100
                 ....*....|....*....|....*.
gi 446521361  79 VVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17575   79 IVLSTKEEPEVKSEAFALGANDYLVK 104
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 3-114 1.60e-07

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 47.82  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:cd17563    2 SLLLVDDDEVFAERLARALERR-GFEVE-TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446521361  83 SF------LDDEKLypvieaGATSYLLKTSRASDIADA 114
Cdd:cd17563   80 GYasiataVEAIKL------GADDYLAKPADADEILAA 111
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 2-104 1.71e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 48.10  E-value: 1.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLStQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAII--QEWPEAKIV 79
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLK-ELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRadGALSHLPVL 79

                         90       100
                 ....*....|....*....|....*
gi 446521361  80 VVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd19923   80 MVTAEAKKENVIAAAQAGVNNYIVK 104
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-81 2.47e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 47.45  E-value: 2.47e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQ-PDIEVvgeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEgAEVTT---AHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAI 76
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-164 5.87e-07

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 48.26  E-value: 5.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLstQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQeWPEAKIVV 80
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTAL--EGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQ-WSAIPVIV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRAT---YDGETVLEP-----KVTGKMMSRMRQKKEQPLHddLTER 152
Cdd:PRK10529  78 LSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVAlrrHSATPAPDPlvkfsDVTVDLAARVIHRGEEEVH--LTPI 155

                        170
                 ....*....|....
gi 446521361 153 EFEIL--LLIAEGK 164
Cdd:PRK10529 156 EFRLLavLLNNAGK 169
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-82 6.16e-07

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 46.81  E-value: 6.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQP-DIEVVgeaENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGyKVTHV---ETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77
PRK10188 PRK10188
transcriptional regulator SdiA;
97-203 1.01e-06

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 47.86  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  97 GATSYLLKTSRASDIADAVRATYDGETVLEPKVTGKM----------MSRMRQKKEQPLHDDLTEREFEILLLIAEGKSN 166
Cdd:PRK10188 118 GVTQCLMLPNRALGFLSFSRCSAREIPILSDELELRLqllvreslmaLMRLEDEMVMTPEMNFSKREKEILKWTAEGKTS 197

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446521361 167 QEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYA 203
Cdd:PRK10188 198 AEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACYA 234
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 30-104 1.21e-06

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 45.78  E-value: 1.21e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446521361  30 VGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAK---IVVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17598   25 VQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRK-IKSDPDLKdipVILLTTLSDPRDVIRGLECGADNFITK 101
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 2-71 1.48e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 47.92  E-value: 1.48e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQpdIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQ 71
Cdd:PRK11107 668 LTVMAVDDNPANLKLIGALLEEQ--VEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRQ 735
PRK11517 PRK11517
DNA-binding response regulator HprR;
2-161 3.28e-06

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 46.04  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPdiEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAKIVVV 81
Cdd:PRK11517   1 MKILLIEDNQRTQEWVTQGLSEAG--YVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQT-LRTAKQTPVICL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGETVLEP--KVTGKMMSRMRQKKEQP-LHDDLTEREFEILL 158
Cdd:PRK11517  78 TARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNStlEISGLRMDSVSQSVSRDnISITLTRKEFQLLW 157


                 ...
gi 446521361 159 LIA 161
Cdd:PRK11517 158 LLA 160
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 1-106 3.69e-06

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 46.17  E-value: 3.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   1 MIKVLLVDDHEMVRMGVSAYLSTQpDIEVVGEAEnGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPeAKIVV 80
Cdd:PRK10701   1 MNKIVFVEDDAEVGSLIAAYLAKH-DIDVTVEPR-GDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQ-GPIVL 77

                         90       100
                 ....*....|....*....|....*.
gi 446521361  81 VTSFLDDEKLYPVIEAGATSYLLKTS 106
Cdd:PRK10701  78 LTSLDSDMNHILALEMGACDYILKTT 103
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-104 4.13e-06

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 44.30  E-value: 4.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIevVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYE--VETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTA 78

                         90       100
                 ....*....|....*....|.
gi 446521361  84 FLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17627   79 RDSVSDRVAGLDAGADDYLVK 99
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 3-116 5.24e-06

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 44.08  E-value: 5.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLstQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVT 82
Cdd:cd17553    2 KILIVDDQYGIRILLNEVF--NKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMT 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:cd17553   80 AYGELDMIQESKELGALTHFAKPFDIDEIRDAVK 113
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-105 6.23e-06

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 43.91  E-value: 6.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLStQPDIEVVGEaENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWpEAKIVVVT 82
Cdd:cd17622    2 RILLVEDDPKLARLIADFLE-SHGFNVVVE-HRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKY-QGPILLLT 78

                         90       100
                 ....*....|....*....|...
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLKT 105
Cdd:cd17622   79 ALDSDIDHILGLELGADDYVVKP 101
PRK15347 PRK15347
two component system sensor kinase;
2-181 8.64e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 45.79  E-value: 8.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQPdiEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRaiiqEW-------- 73
Cdd:PRK15347 691 LQILLVDDVETNRDIIGMMLVELG--QQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQ----LWrddpnnld 764

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  74 PEAKIVVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYDGEtvLEpkvtgKMMSRMRQKK-EQPLHD----D 148
Cdd:PRK15347 765 PDCMIVALTANAAPEEIHRCKKAGMNHYLTKPVTLAQLARALELAAEYQ--LL-----RGIELSPQDSsCSPLLDtddmA 837

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446521361 149 LTEREFE-ILLLIAEGKSNQEIADELFIALKTVK 181
Cdd:PRK15347 838 LNSKLYQsLLLLLAQIEQAVENQEVLSQLLHTLK 871
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-82 9.16e-06

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 43.25  E-value: 9.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTqpdiE--VVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd17550    1 ILIVDDEEDIRESLSGILED----EgyEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMI 76


                 .
gi 446521361  82 T 82
Cdd:cd17550   77 S 77
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
30-104 1.80e-05

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 44.64  E-value: 1.80e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446521361  30 VGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:PRK10365  32 VALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIK 106
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 4-104 2.48e-05

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 41.98  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLStQPDIEVVgEAENGRKGSELALQLRP---------DIILMDLVMDEMDGVEATrAIIQEWP 74
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLK-NLGFEIA-EAVDGEEALNKLENLAKegndlskelDLIITDIEMPKMDGYELT-FELRDDP 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446521361  75 ---EAKIVVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd19924   78 rlaNIPVILNSSLSGEFSRARGKKVGADAYLAK 110
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-117 3.60e-05

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 42.02  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEM-VRMGVSAYLSTQPDIEVVgEAENG-------RKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEwP 74
Cdd:cd17557    1 TILLVEDNPGdAELIQEAFKEAGVPNELH-VVRDGeealdflRGEGEYADAPRPDLILLDLNMPRMDGFEVLREIKAD-P 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446521361  75 EAK---IVVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRA 117
Cdd:cd17557   79 DLRripVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRS 124
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-104 4.09e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 41.57  E-value: 4.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQP-DIEVvgeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGwDVET---AADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFL 77

                         90       100
                 ....*....|....*....|...
gi 446521361  82 TSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17615   78 TAKDSVEDRIAGLTAGGDDYVTK 100
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-86 4.96e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 41.23  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRRE-GYEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILL 78


                 ....*
gi 446521361  82 TSFLD 86
Cdd:cd17569   79 TGYAD 83
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 3-104 4.97e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 41.28  E-value: 4.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLSTQPDIEVVgeAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEwPEAKIVVVT 82
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFDVTA--AADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRAR-SDVPIIIIS 77

                         90       100
                 ....*....|....*....|...
gi 446521361  83 SFLDDEKLYPV-IEAGATSYLLK 104
Cdd:cd17594   78 GDRRDEIDRVVgLELGADDYLAK 100
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-104 5.79e-05

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 41.14  E-value: 5.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLStqPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEwPEAKIVVVTS 83
Cdd:cd17623    1 ILLIDDDRELTELLTEYLE--MEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKT-SQVPVLMLTA 77

                         90       100
                 ....*....|....*....|.
gi 446521361  84 FLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17623   78 RGDDIDRILGLELGADDYLPK 98
PRK10693 PRK10693
two-component system response regulator RssB;
32-116 7.14e-05

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 42.67  E-value: 7.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  32 EAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSflddeklypvieagatsyllkTSRASDI 111
Cdd:PRK10693   2 LAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISA---------------------TENMADI 60


                 ....*
gi 446521361 112 ADAVR 116
Cdd:PRK10693  61 AKALR 65
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 45-117 1.66e-04

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 39.76  E-value: 1.66e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446521361  45 QLRPDIILMDLVMDEMDGVEATRaIIQEWPEAKIVVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRA 117
Cdd:cd17626   42 EVRPDLVLLDLMLPGIDGIEVCR-QIRAESGVPIVMLTAKSDTVDVVLGLESGADDYVAKPFKPKELVARIRA 113
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-64 1.69e-04

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 39.28  E-value: 1.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQpDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVE 64
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQ-GFTVI-AASNGLEALDLLNQYIPDLIISDIIMPGVDGYS 59
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-84 1.85e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 39.25  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIevVGEAENGRKG-SELALQLRPDIILMDLVM-DEMDGVEATRAIIQEWPEAKIVVV 81
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYT--VLEAASGDEAlDLLESGPDIDLLVTDVIMpGGMNGSQLAEEARRRRPDLKVLLT 78


                 ...
gi 446521361  82 TSF 84
Cdd:cd18161   79 SGY 81
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 149-191 2.43e-04

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 37.82  E-value: 2.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446521361  149 LTEREFEILLLIA-EGKSNQEIADELFIALKTVKTHVSNILNKL 191
Cdd:pfam08281  11 LPPRQREVFLLRYlEGLSYAEIAELLGISEGTVKSRLSRARKKL 54
pleD PRK09581
response regulator PleD; Reviewed
 33-104 2.68e-04

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 41.04  E-value: 2.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446521361  33 AENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAK---IVVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:PRK09581  32 ASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRR-LKSDPATThipVVMVTALDDPEDRVRGLEAGADDFLTK 105
fixJ PRK09390
response regulator FixJ; Provisional
 4-191 3.01e-04

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 40.37  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVsAYLSTQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:PRK09390   6 VHVVDDDEAMRDSL-AFLLDSAGFEVR-LFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  84 FLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYD--GETVLEPKVTGKMMSRMRQkkeqplhddLTEREFEILLLIA 161
Cdd:PRK09390  84 HGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAqaPEAAKSEAVAADIRARIAS---------LSERERQVMDGLV 154

                        170       180       190
                 ....*....|....*....|....*....|
gi 446521361 162 EGKSNQEIADELFIALKTVKTHVSNILNKL 191
Cdd:PRK09390 155 AGLSNKVIARDLDISPRTVEVYRANVMTKM 184
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 162-191 3.53e-04

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 39.47  E-value: 3.53e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 446521361  162 EGKSNQEIADELFIALKTVKTHVSNILNKL 191
Cdd:TIGR02985 128 EGLSNKEIAEELGISVKTVEYHITKALKFL 157
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 147-191 5.34e-04

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 39.21  E-value: 5.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446521361 147 DDLTEREFEILLLIA-EGKSNQEIADELFIALKTVKTHVSNILNKL 191
Cdd:COG1595  126 ERLPPRQREVLVLRYlEGLSYAEIAEILGISEGTVKSRLSRARKKL 171
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 3-69 5.66e-04

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 38.58  E-value: 5.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446521361   3 KVLLVDDHEMVRMgVSAYLSTQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAI 69
Cdd:cd17530    2 RVLVLDDDPFQCM-MAATILEDLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHL 67
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 147-191 5.84e-04

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 38.87  E-value: 5.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446521361  147 DDLTEREFEILLLIA-EGKSNQEIADELFIALKTVKTHVSNILNKL 191
Cdd:TIGR02937 109 EKLPEREREVLVLRYlEGLSYKEIAEILGISVGTVKRRLKRARKKL 154
PRK13719 PRK13719
conjugal transfer transcriptional regulator TraJ; Provisional
 132-205 6.30e-04

conjugal transfer transcriptional regulator TraJ; Provisional


Pssm-ID: 237479  Cd Length: 217  Bit Score: 39.33  E-value: 6.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446521361 132 KMMSRMRQKKEqplhddLTEREFEILLLIAEGKSNQEIADELFIALKTVKTHVSNILNKLNVSDRTQAVIYAFR 205
Cdd:PRK13719 133 GLSTNLEAKNK------VTKYQNDVFILYSFGFSHEYIAQLLNITVGSSKNKISEILKFFGISSRDELLIILHT 200
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 4-116 7.03e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 38.50  E-value: 7.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQPDIEVVGEAENGRKGSElalQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:cd17596    3 ILVVDDEVRSLEALRRTLEEDFDVLTAASAEEALAILE---EEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIISG 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446521361  84 FLDDEKLYPVI-EAGATSYLLKTSRASDIADAVR 116
Cdd:cd17596   80 YTDSEDIIAGInEAGIYQYLTKPWHPDQLLLTVR 113
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-104 1.11e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 37.40  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   4 VLLVDDHEMVRMGVSAYLsTQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAKIVVVTS 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNL-TKEGYEVV-TAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCRE-VRKTSNVPIIMLTA 77

                         90       100
                 ....*....|....*....|...
gi 446521361  84 flDDEKLYPVI--EAGATSYLLK 104
Cdd:cd17614   78 --KDSEVDKVLglELGADDYVTK 98
rcsA PRK15411
transcriptional regulator RcsA;
14-202 2.12e-03

transcriptional regulator RcsA;


Pssm-ID: 185309 [Multi-domain]  Cd Length: 207  Bit Score: 37.80  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  14 RMGVSAYLSTQPDI-EVVGEAENGRKGSELALQLRPDIILM--DLVMDEMDGVEATRAIIQEWPEAKIVV---VTSFLDD 87
Cdd:PRK15411  13 RLGLTGYLLSRGVKkREINDIETVDDLAIACDSLRPSVVFIneDCFIHDASNSQRIKQIINQHPNTLFIVfmaIANIHFD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361  88 EKLYpvieagATSYLLKTSR--ASDIADAVRATYdgetvlepkvTGKMMSRMRQKKEQPLHDDLTEREfeILLLIAEGKS 165
Cdd:PRK15411  93 EYLL------VRKNLLISSKsiKPESLDDLLGDI----------LKKETTITSFLNLPTLSLSRTESS--MLRMWMAGQG 154

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446521361 166 NQEIADELFIALKTVKTHVSNILNKLNVSDRTqaVIY 202
Cdd:PRK15411 155 TIQISDQMNIKAKTVSSHKGNIKRKIKTHNKQ--VIY 189
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 47-115 2.12e-03

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 36.48  E-value: 2.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446521361  47 RPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSFLDDEKLYPVIEAGATSYLLKtsrASDIADAV 115
Cdd:cd19919   44 QPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPK---PFDIDEAV 109
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 49-116 3.03e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 36.45  E-value: 3.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446521361  49 DIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVR 116
Cdd:cd17533   55 YFLDIDIKMEEKNGLEVAQKIRKYDPYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKKRIE 122
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 30-104 3.10e-03

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 36.10  E-value: 3.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446521361  30 VGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTSFLDDEKLYPVI--EAGATSYLLK 104
Cdd:cd19937   24 VVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSIPIIMLTAKGEEFDKVLglELGADDYITK 100
PRK15115 PRK15115
response regulator GlrR; Provisional
 30-83 3.27e-03

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 37.89  E-value: 3.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446521361  30 VGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAIIQEWPEAKIVVVTS 83
Cdd:PRK15115  32 VVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTA 85
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-104 4.60e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 35.82  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLstQPDIEVVGEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAKIVVVT 82
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYL--RAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCRE-IRRFSDVPIIMVT 77

                         90       100
                 ....*....|....*....|..
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd19938   78 ARVEEIDRLLGLELGADDYICK 99
PRK10610 PRK10610
chemotaxis protein CheY;
2-120 4.94e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 35.72  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   2 IKVLLVDDHEMVRMGVSAYLStQPDIEVVGEAENGrkgSELALQLRP---DIILMDLVMDEMDGVEATRAIIQEWPEAKI 78
Cdd:PRK10610   6 LKFLVVDDFSTMRRIVRNLLK-ELGFNNVEEAEDG---VDALNKLQAggfGFVISDWNMPNMDGLELLKTIRADGAMSAL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446521361  79 VV--VTSFLDDEKLYPVIEAGATSYLLKTSRASDIADAVRATYD 120
Cdd:PRK10610  82 PVlmVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFE 125
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
 147-191 5.07e-03

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 34.00  E-value: 5.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446521361 147 DDLTEREFEILLLI-AEGKSNQEIADELFIALKTVKTHVSNILNKL 191
Cdd:cd06171    9 DKLPEREREVILLRfGEGLSYEEIAEILGISRSTVRQRLHRALKKL 54
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 3-104 5.34e-03

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 35.69  E-value: 5.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLsTQPDIEVVgEAENGRKGSELALQLRPDIILMDLVMDEMDGVEATR-----AIIQEWPeak 77
Cdd:cd17618    2 TILIVEDEPAIREMIAFNL-ERAGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRrlkrdEMTRDIP--- 76

                         90       100
                 ....*....|....*....|....*..
gi 446521361  78 IVVVTSFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd17618   77 IIMLTARGEEEDKVRGLEAGADDYITK 103
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 4-64 6.58e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 35.04  E-value: 6.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446521361   4 VLLVDDHEMVRMGVSAYLSTQpDIEVVGEAENGRKGSELaLQLRPDIILMDLVMDEMDGVE 64
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQ-GFRVVVIDDPLRALTTL-LNSKPDLILIDIDMPDLDGYE 59
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-104 6.89e-03

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 35.04  E-value: 6.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446521361   3 KVLLVDDHEMVRMGVSAYLsTQPDIEVVGEAeNGRKGSELALQLRPDIILMDLVMDEMDGVEATRAiIQEWPEAKIVVVT 82
Cdd:cd19939    1 RILIVEDELELARLTRDYL-IKAGLEVSVFT-DGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCRE-VREHSHVPILMLT 77

                         90       100
                 ....*....|....*....|..
gi 446521361  83 SFLDDEKLYPVIEAGATSYLLK 104
Cdd:cd19939   78 ARTEEMDRVLGLEMGADDYLCK 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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