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Conserved domains on  [gi|446529200|ref|WP_000606546|]
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MULTISPECIES: nitrate respiration regulation sensor histidine kinase NreB [Staphylococcus]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
117-344 4.70e-64

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 203.70  E-value: 4.70e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 117 AFTLQNVSSQIEQQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQ--EDTTKLLEDAENIEYI 194
Cdd:COG4585   21 LLALVLLRARRAERAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLldADPEAAREELEEIREL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 195 VAKLIDDIRNMSVELRPASLDDLGLEAAFKSYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADV 274
Cdd:COG4585  101 AREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGA 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 275 NEINVGIRQTGRHLVAEVIDAGNGFDPSSKPkGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG4585  181 TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP-GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
117-344 4.70e-64

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 203.70  E-value: 4.70e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 117 AFTLQNVSSQIEQQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQ--EDTTKLLEDAENIEYI 194
Cdd:COG4585   21 LLALVLLRARRAERAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLldADPEAAREELEEIREL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 195 VAKLIDDIRNMSVELRPASLDDLGLEAAFKSYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADV 274
Cdd:COG4585  101 AREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGA 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 275 NEINVGIRQTGRHLVAEVIDAGNGFDPSSKPkGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG4585  181 TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP-GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
129-340 4.68e-29

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 116.62  E-value: 4.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 129 QQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQE-DTTKLLEDAENIEYIVAKLIDDIRNMSV 207
Cdd:PRK11644 281 QKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRTQAGIIKRLAaDNASVKQSAQLIEQLSLGVYDTVRRLLG 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 208 ELRPASLDDLGLEAAFKSYFKQFE-ENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADVNEINVGIRQTGR 286
Cdd:PRK11644 361 RLRPRQLDDLTLEQAIRSLMREMElEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDE 440

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446529200 287 HLVAEVIDAGNGFDPSSKPKgsGLGLYGMNERAELVSGSVNIETKIGEGTNVTL 340
Cdd:PRK11644 441 RLMLVIEDDGSGLPPGSGQQ--GFGLRGMRERVTALGGTLTISCTHGTRLSVSL 492
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 257-343 5.13e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 104.56  E-value: 5.13e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 257 VYRVVQEAILNALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKGSGLGLYGMNERAELVSGSVNIETKIGEGT 336
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80


                 ....*..
gi 446529200 337 NVTLNIP 343
Cdd:cd16917   81 RVTARLP 87
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 257-344 1.04e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 72.30  E-value: 1.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200   257 VYRVVQEAILNALKYA-DVNEINVGIRQTGRHLVAEVIDAGNGFDP----------------SSKPKGSGLGLYGMNERA 319
Cdd:smart00387   6 LRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPedlekifepffrtdkrSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*
gi 446529200   320 ELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:smart00387  86 ELHGGEISVESEPGGGTTFTITLPL 110
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 149-214 7.30e-14

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 65.72  E-value: 7.30e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446529200  149 ERKRISRELHDSVIQEMLNVDVQLRLLKYQ--EDTTKLLEDAENIEYIVAKLIDDIRNMSVELRPASL 214
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLldRDPEEAREQLDAIRELAREALQELRRLLGDLRPPAL 68
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
117-344 4.70e-64

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 203.70  E-value: 4.70e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 117 AFTLQNVSSQIEQQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQ--EDTTKLLEDAENIEYI 194
Cdd:COG4585   21 LLALVLLRARRAERAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLldADPEAAREELEEIREL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 195 VAKLIDDIRNMSVELRPASLDDLGLEAAFKSYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADV 274
Cdd:COG4585  101 AREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGA 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 275 NEINVGIRQTGRHLVAEVIDAGNGFDPSSKPkGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG4585  181 TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP-GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 114-343 2.99e-36

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 136.68  E-value: 2.99e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 114 GIHAFTLQNVSSQIEQQEKlhqQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQEDTTKLLEDAENIEY 193
Cdd:COG3851  260 AIQRQRQLNQQLEQELREN---RALARQLVSAEESERREIARELHDEIGQNITAIRTQASILKRLAPQPEIEQSAQSIES 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 194 IVAKLIDDIRNMSVELRPASLDDLGLEAAFKSYFKQFEENYGiKIIYTSNIKN--TRFDSDIETVVYRVVQEAILNALKY 271
Cdd:COG3851  337 LALRIYDTTRRLLDRLRPAVLDELGLEEALRELPRELAFEEP-GISCQLDLRGdpSLLDDTLQLTLYRLVQEALTNILKH 415

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446529200 272 ADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKgsGLGLYGMNERAELVSGSVNIETkIGEGTNVTLNIP 343
Cdd:COG3851  416 AEASQIRISLSQDKRLLSLEIRDDGIGLPPELRAK--GFGLRGMRERVRALGGDFRLSS-APKGTRLSVLLP 484
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
129-340 4.68e-29

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 116.62  E-value: 4.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 129 QQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQE-DTTKLLEDAENIEYIVAKLIDDIRNMSV 207
Cdd:PRK11644 281 QKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRTQAGIIKRLAaDNASVKQSAQLIEQLSLGVYDTVRRLLG 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 208 ELRPASLDDLGLEAAFKSYFKQFE-ENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADVNEINVGIRQTGR 286
Cdd:PRK11644 361 RLRPRQLDDLTLEQAIRSLMREMElEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDE 440

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446529200 287 HLVAEVIDAGNGFDPSSKPKgsGLGLYGMNERAELVSGSVNIETKIGEGTNVTL 340
Cdd:PRK11644 441 RLMLVIEDDGSGLPPGSGQQ--GFGLRGMRERVTALGGTLTISCTHGTRLSVSL 492
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 257-343 5.13e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 104.56  E-value: 5.13e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 257 VYRVVQEAILNALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKGSGLGLYGMNERAELVSGSVNIETKIGEGT 336
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80


                 ....*..
gi 446529200 337 NVTLNIP 343
Cdd:cd16917   81 RVTARLP 87
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 257-344 1.04e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 72.30  E-value: 1.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200   257 VYRVVQEAILNALKYA-DVNEINVGIRQTGRHLVAEVIDAGNGFDP----------------SSKPKGSGLGLYGMNERA 319
Cdd:smart00387   6 LRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPedlekifepffrtdkrSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*
gi 446529200   320 ELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:smart00387  86 ELHGGEISVESEPGGGTTFTITLPL 110
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
128-344 2.61e-14

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 71.48  E-value: 2.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 128 EQQEKLHQQRMMRKTISAqenerkRISRELHD--SVIQ---EMLNVDVQLRLLKYQEDTTKLLEDAENIEyivaKLIDDI 202
Cdd:COG2205    4 EALEELEELERLKSEFLA------NVSHELRTplTSILgaaELLLDEEDLSPEERRELLEIIRESAERLL----RLIEDL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 203 RNMS--------VELRPASLDDLgLEAAFKSYFKQFEENyGIKIIYTSNIKNTRFDSDiETVVYRVVQEAILNALKYADV 274
Cdd:COG2205   74 LDLSrlesgklsLELEPVDLAEL-LEEAVEELRPLAEEK-GIRLELDLPPELPLVYAD-PELLEQVLANLLDNAIKYSPP 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 275 N-EINVGIRQTGRHLVAEVIDAGNG---------FDP------SSKPKGSGLGLY---GMnerAELVSGSVNIETKIGEG 335
Cdd:COG2205  151 GgTITISARREGDGVRISVSDNGPGipeeeleriFERfyrgdnSRGEGGTGLGLAivkRI---VEAHGGTIWVESEPGGG 227


                 ....*....
gi 446529200 336 TNVTLNIPI 344
Cdd:COG2205  228 TTFTVTLPL 236
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 149-214 7.30e-14

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 65.72  E-value: 7.30e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446529200  149 ERKRISRELHDSVIQEMLNVDVQLRLLKYQ--EDTTKLLEDAENIEYIVAKLIDDIRNMSVELRPASL 214
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLldRDPEEAREQLDAIRELAREALQELRRLLGDLRPPAL 68
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 254-343 2.16e-13

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 65.47  E-value: 2.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  254 ETVVYRVVQEAILNALKYA-DVNEINVGIRQTGRHLVaEVIDAGNGFDP--------------SSKPKGSGLGLYGMNER 318
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAaKAGEITVTLSEGGELTL-TVEDNGIGIPPedlprifepfstadKRGGGGTGLGLSIVRKL 81

                          90       100
                  ....*....|....*....|....*
gi 446529200  319 AELVSGSVNIETKIGEGTNVTLNIP 343
Cdd:pfam02518  82 VELLGGTITVESEPGGGTTVTLTLP 106
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 19-344 2.46e-11

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 64.10  E-value: 2.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  19 HSI-EKIVFADDNGKIIAMNDAAKDILSEEDNYSAVAnaichrcegytnaydvqsckDCFLESMQVQATNFQVFMktkDQ 97
Cdd:COG3290   91 ESIrEGVIAVDRDGRITLINDAARRLLGLDAIGRPID--------------------EVLAEVLETGERDEEILL---NG 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  98 KVMPFTATYQLIDQDRGIHAFTLQNVSSQIEQQEKLHQQRMMRKTISAQENErkrISRELHdsVIQEMLNvdvqlrLLKY 177
Cdd:COG3290  148 RVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQRHD---FRNHLH--TISGLLQ------LGEY 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 178 QEDTTKLLEDAENIEYIVAKLIDDIRNmsvelrPAslddlgLEAAFKSYFKQFEENyGIKIIYT--SNIKNTRFDS-DIE 254
Cdd:COG3290  217 DEALEYIDEISEELQELIDSLLSRIGN------PV------LAALLLGKAARARER-GIDLTIDidSDLPDLPLSDtDLV 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 255 TVVYrvvqEAILNALKYADVNE-----INVGIRQTGRHLVAEVIDAGNGFDP-----------SSKPK-GSGLGLYGMNE 317
Cdd:COG3290  284 TILG----NLLDNAIEAVEKLPeeerrVELSIRDDGDELVIEVEDSGPGIPEellekifergfSTKLGeGRGLGLALVKQ 359

                        330       340
                 ....*....|....*....|....*..
gi 446529200 318 RAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG3290  360 IVEKYGGTIEVESEEGEGTVFTVRLPK 386
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
149-343 2.66e-11

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 64.49  E-value: 2.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 149 ERKRISRELHDSVIQEMLNVDVQLRLLKYQEDttkllEDAENIEYIVAKLIDDIRNMSVELRPA------SLDDLGLEAA 222
Cdd:PRK10935 363 ERATIARELHDSLAQVLSYLKIQLTLLKRSLD-----EDNAKAQSIIAEFDQALSDAYRQLRELlttfrlTIQEANLGSA 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 223 FKSYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADVNEINVGIRQT--GRHLVaEVIDAGNGFD 300
Cdd:PRK10935 438 LEEMLDQLRNQTDAKITLDCRLPSQALDAQQQVHLLQIIREATLNAIKHANASEIAVSCVTNpdGEHTV-SIRDDGIGIG 516

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446529200 301 PSSKPKGS-GLGLygMNERAELVSGSVNIETKIGEGTNVTLNIP 343
Cdd:PRK10935 517 ELKEPEGHyGLNI--MQERAERLGGTLTISQPPGGGTTVSLTFP 558
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
176-344 4.06e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 63.39  E-value: 4.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 176 KYQEDTTKLLEDAENIEYIVAKLID----DIRNMSVELRPASLDDLgLEAAFKSYFKQFEENyGIKIIYTSNIKNTRFDS 251
Cdd:COG0642  142 EQREYLETILRSADRLLRLINDLLDlsrlEAGKLELEPEPVDLAEL-LEEVVELFRPLAEEK-GIELELDLPDDLPTVRG 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 252 DiETVVYRVVQEAILNALKYADVNE-INVGIRQTGRHLVAEVIDAGNG---------FDP------SSKPKGSGLGLYGM 315
Cdd:COG0642  220 D-PDRLRQVLLNLLSNAIKYTPEGGtVTVSVRREGDRVRISVEDTGPGippedleriFEPffrtdpSRRGGGTGLGLAIV 298

                        170       180
                 ....*....|....*....|....*....
gi 446529200 316 NERAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG0642  299 KRIVELHGGTIEVESEPGKGTTFTVTLPL 327
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
129-338 6.59e-11

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 63.15  E-value: 6.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 129 QQEklHQQRMMRKtisaqeNERKRISRELHDSVIQEMLNVDVQLRLLKYQEDTtklLEDAENieyivaKLIDDIRNmsvE 208
Cdd:PRK10600 349 QQE--RQQQLIVM------EERATIARELHDSIAQSLSCMKMQVSCLQMQGDA---LPESSR------ELLSQIRN---E 408

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 209 LRPA-------------SLDDLGLEAAFKSYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADVN 275
Cdd:PRK10600 409 LNASwrqlrellttfrlQLTEPGLRPALEASCEEFSARFGFPVKLDYQLPPRLVPSHQAIHLLQIAREALSNALKHAQAS 488

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446529200 276 EINVGIRQTGRHLVAEVIDAGNGFDPSSKpKGSGLGLYGMNERAELVSGSVNIETKIGEGTNV 338
Cdd:PRK10600 489 EVVVTVAQNQNQVKLSVQDNGCGVPENAE-RSNHYGLIIMRDRAQSLRGDCRVRRRESGGTEV 550
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
24-344 6.77e-09

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 56.78  E-value: 6.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  24 IVFADDNGKIIAMNDAAKDILseedNYSAvanaicHRCEGyTNAYDVQSCKDCFLESMQ------VQATNFQVFMKTKDQ 97
Cdd:COG3852   20 VIVLDADGRITYVNPAAERLL----GLSA------EELLG-RPLAELFPEDSPLRELLEralaegQPVTEREVTLRRKDG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  98 KVMPFTATYQLIDQDRGIHAFTLqnVSSQIEQQEKLHQQRmmrktisaQENERKRISREL-----HD------------S 160
Cdd:COG3852   89 EERPVDVSVSPLRDAEGEGGVLL--VLRDITERKRLEREL--------RRAEKLAAVGELaaglaHEirnpltgirgaaQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 161 VIQEMLNVDvqlrllKYQEDTTKLLEDAENIEYIVAKLIDDIRNMSVELRPASLDDLgLEAAFKSYFKQFEENYGIKIIY 240
Cdd:COG3852  159 LLERELPDD------ELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEV-LERVLELLRAEAPKNIRIVRDY 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 241 TSNIKNTRFDSDietvvyRVVQeAILN-------A--------LKYADVNEINVGIRQTGRHLVAEVIDAGNG------- 298
Cdd:COG3852  232 DPSLPEVLGDPD------QLIQ-VLLNlvrnaaeAmpeggtitIRTRVERQVTLGGLRPRLYVRIEVIDNGPGipeeild 304

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446529200 299 --FDP--SSKPKGSGLGL---YGmneraeLVS---GSVNIETKIGEGTNVTLNIPI 344
Cdd:COG3852  305 riFEPffTTKEKGTGLGLaivQK------IVEqhgGTIEVESEPGKGTTFRIYLPL 354
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 165-344 1.26e-08

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 55.96  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 165 MLNVDVQLRLLKYQEDTTKLLEDAENIEYIV---AKLIDDIRNMS----VELRPASLDDLgLEAAFKSYFKQFEENyGIK 237
Cdd:COG4191  161 LGNAELLRRRLEDEPDPEELREALERILEGAeraAEIVRSLRAFSrrdeEEREPVDLNEL-IDEALELLRPRLKAR-GIE 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 238 IIytsniknTRFDSDIETV-VYRV-VQEAILN-------ALKYADVNEINVGIRQTGRHLVAEVIDAGNG---------F 299
Cdd:COG4191  239 VE-------LDLPPDLPPVlGDPGqLEQVLLNllinaidAMEEGEGGRITISTRREGDYVVISVRDNGPGippevleriF 311

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446529200 300 DP--SSKP--KGSGLGL---YGMnerAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG4191  312 EPffTTKPvgKGTGLGLsisYGI---VEKHGGRIEVESEPGGGTTFTITLPL 360
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
252-340 1.89e-08

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 52.22  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 252 DIETVVYrvvqEAILNALKYADVN----EINVGIRQTGRHLVAEVIDAGNGFDPSSKP------KGSGLGLYGMNeraEL 321
Cdd:COG2172   34 DLVLAVS----EAVTNAVRHAYGGdpdgPVEVELELDPDGLEIEVRDEGPGFDPEDLPdpystlAEGGRGLFLIR---RL 106

                         90
                 ....*....|....*....
gi 446529200 322 VSgSVNIETKiGEGTNVTL 340
Cdd:COG2172  107 MD-EVEYESD-PGGTTVRL 123
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
197-344 1.98e-08

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 55.33  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 197 KLIDDIRNMS--------VELRPASLDDLgLEAAFKSyFKQFEENYGIKIIYTSNIKNTRFDSDiETVVYRVVQEAILNA 268
Cdd:COG5002  217 RLVNDLLDLSrlesgelkLEKEPVDLAEL-LEEVVEE-LRPLAEEKGIELELDLPEDPLLVLGD-PDRLEQVLTNLLDNA 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 269 LKYADVN-EINVGIRQTGRHLVAEVIDAGNG---------FDP--------SSKPKGSGLGLYGMNERAELVSGSVNIET 330
Cdd:COG5002  294 IKYTPEGgTITVSLREEDDQVRISVRDTGIGipeedlpriFERfyrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVES 373

                        170
                 ....*....|....
gi 446529200 331 KIGEGTNVTLNIPI 344
Cdd:COG5002  374 EPGKGTTFTITLPL 387
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 134-344 5.27e-08

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 54.14  E-value: 5.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 134 HQQRMMRKTISAQENERKRISRELHD------SVIQEMLNVdvQLRLLKyQEDTTKLLEDAEN----IEYIVAKLIDdir 203
Cdd:COG3920  279 TERKRAEEELEASLEEKELLLRELHHrvknnlQVVSSLLRL--QARRAD-DPEAREALEESQNriqaLALVHELLYQ--- 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 204 nmSVELRPASLDDLgLEAAFKSYFKQFEENyGIKIiyTSNIKNTRFDSDIETVVYRVVQEAILNALKYA----DVNEINV 279
Cdd:COG3920  353 --SEDWEGVDLRDY-LRELLEPLRDSYGGR-GIRI--ELDGPDVELPADAAVPLGLILNELVTNALKHAflsgEGGRIRV 426

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446529200 280 GIRQTGRHLVAEVIDAGNGFDPS-SKPKGSGLGLYGMNERAELVSGSVNIETkiGEGTNVTLNIPI 344
Cdd:COG3920  427 SWRREDGRLRLTVSDNGVGLPEDvDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPL 490
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-343 6.96e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 50.12  E-value: 6.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 260 VVQEAILNALKYA-----DVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKP----------KGSGLGLYGMNERAELVSG 324
Cdd:cd16957    5 ALQVLVENAIRHAfpkrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDllgkttvtseKGTGTALENLNRRLIGLFG 84

                         90       100
                 ....*....|....*....|..
gi 446529200 325 SV---NIETKIGEGTNVTLNIP 343
Cdd:cd16957   85 SEaclHIESEVHGGTEVWFVIP 106
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 24-344 9.89e-08

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 53.04  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  24 IVFaDDNGKIIAMNDAAKDILSEEDnysavANAICHRCEGYTNAYDV-QSCKDCFLESMQVQATNFQVFMKTKDQKVMPF 102
Cdd:COG5000  104 IVL-DADGRITLANPAAERLLGIPL-----EELIGKPLEELLPELDLaELLREALERGWQEEIELTRDGRRTLLVRASPL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 103 TATYQLIdqdrgihafTLQNVSSQIEQQEKLHQQRMMRktisaqenerkRISrelHD-----SVIQ---EMLNVDVQLRL 174
Cdd:COG5000  178 RDDGYVI---------VFDDITELLRAERLAAWGELAR-----------RIA---HEiknplTPIQlsaERLRRKLADKL 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 175 LKYQEDTTKLLEDAEN-IEYIvAKLIDDIRNMS----VELRPASLDDLGLEAAFKSYFKQFEENYGIKIIYTSNIKNTRF 249
Cdd:COG5000  235 EEDREDLERALDTIIRqVDRL-KRIVDEFLDFArlpePQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLA 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 250 DSD-IETVVYRVVQ---EAIlnalkyADVNEINVGIRQTGRHLVAEVIDAGNGFDP-----------SSKPKGSGLGLYg 314
Cdd:COG5000  314 DRDqLEQVLINLLKnaiEAI------EEGGEIEVSTRREDGRVRIEVSDNGPGIPEevlerifepffTTKPKGTGLGLA- 386

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 446529200 315 mneraeLVS-------GSVNIETKIGEGTNVTLNIPI 344
Cdd:COG5000  387 ------IVKkiveehgGTIELESRPGGGTTFTIRLPL 417
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 261-343 5.75e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 47.43  E-value: 5.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 261 VQEAILNALKY-----ADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKG-----SGLGLYGMNERAELVSGS---VN 327
Cdd:cd16956    6 LQPIVENAVKHglsglLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARIlirssNGLGLNLVDKRLRQAFGNdygLD 85

                         90
                 ....*....|....*.
gi 446529200 328 IETKIGEGTNVTLNIP 343
Cdd:cd16956   86 IECAPGEGTRITIRLP 101
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-343 2.16e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 45.51  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 260 VVQEAILNALKYA-----DVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKP-------KGSGLGLYGMNERAELVSG--- 324
Cdd:cd16924    5 TLQPLVENAIQHGlspltDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNilgkkpkEGNGIGLYNVHQRLILLFGedy 84

                         90
                 ....*....|....*....
gi 446529200 325 SVNIETKIGEGTNVTLNIP 343
Cdd:cd16924   85 GIHIASEPDKGTRITFTIP 103
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
24-344 2.23e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 49.20  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  24 IVFADDNGKIIAMNDAAKDI--LSEED----NYSAVanaichrcegYTNAYDVQS-CKDCFLESMQVQAtnFQVFMKTKD 96
Cdd:PRK11360 275 VIAIDRQGKITTMNPAAEVItgLQRHElvgkPYSEL----------FPPNTPFASpLLDTLEHGTEHVD--LEISFPGRD 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  97 QKVMPFTATYQLID-QDRGIHA-FTLQNVSSQIEQQEKLHQQrmmrktisaqenERKRISRELHDSVIQEMLN------- 167
Cdd:PRK11360 343 RTIELSVSTSLLHNtHGEMIGAlVIFSDLTERKRLQRRVARQ------------ERLAALGELVAGVAHEIRNpltairg 410

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 168 ----VDVQLRLLKYQEDTTKLLEDAENIEYIVAKLIDDIRNMSVELRPASLDDLGLEAAFksYFKQFEENYGIKIIytsn 243
Cdd:PRK11360 411 yvqiWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQ--LFQTAGVQARVDFE---- 484

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 244 iknTRFDSDIETVVY------RVVQEAILNALKyADVNEINVGIR---QTGRHLVAEVIDAGNG---------FDP--SS 303
Cdd:PRK11360 485 ---TELDNELPPIWAdpellkQVLLNILINAVQ-AISARGKIRIRtwqYSDGQVAVSIEDNGCGidpellkkiFDPffTT 560

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 446529200 304 KPKGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:PRK11360 561 KAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
184-344 5.93e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 47.71  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 184 LLEDAENIEYIVAKLIDDIRNMSVELRPASLddLGLEAAF-KSYFkqfeenygikiiytsNIKNTRFDSDIETVVYrvVQ 262
Cdd:COG2972  268 ELEDPEEAEEMLEALSKLLRYSLSKGDELVT--LEEELELiKSYL---------------EIQKLRFGDRLEVEIE--ID 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 263 EAIL--------------NALKYA-----DVNEINVGIRQTGRHLVAEVIDAGNGFDP----------SSKPKGSGLGLY 313
Cdd:COG2972  329 EELLdllipklilqplveNAIEHGiepkeGGGTIRISIRKEGDRLVITVEDNGVGMPEekleklleelSSKGEGRGIGLR 408

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446529200 314 GMNERAELVSG---SVNIETKIGEGTNVTLNIPI 344
Cdd:COG2972  409 NVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPL 442
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 260-313 6.09e-06

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 44.18  E-value: 6.09e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446529200 260 VVQEAILNALKYADVN----EINVGIRQTGRHLVAEVIDAGNGFDPSSKP------KGSGLGLY 313
Cdd:cd16936    4 AVSEAVTNAVRHAYRHdgpgPVRLELDLDPDRLRVEVTDSGPGFDPLRPAdpdaglREGGRGLA 67
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 285-343 3.06e-05

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 42.75  E-value: 3.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446529200 285 GRHLVAEVIDAGNG---------FDP--SSKP--KGSGLGL---YGMnerAELVSGSVNIETKIGEGTNVTLNIP 343
Cdd:cd16919   45 GNYVCLEVSDTGSGmpaevlrraFEPffTTKEvgKGTGLGLsmvYGF---VKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
254-340 7.44e-05

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 41.89  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  254 ETVVYRV---VQEAILNALKYA----DVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKP-----------KGSGLGLYGM 315
Cdd:pfam13581  26 EELLDEVelaVGEACTNAVEHAyregPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPppdleepdedrKEGGRGLALI 105

                          90       100
                  ....*....|....*....|....*
gi 446529200  316 nerAELVSgSVNIETKiGEGTNVTL 340
Cdd:pfam13581 106 ---RGLMD-DVEYTRG-GEGNTVRM 125
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-343 1.05e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 41.12  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 260 VVQEAILNALKYAD-VNEINVGIRQTGRHLVAEVIDAGNGFDPSSKP----------------KGSGLGLYGMNERAELV 322
Cdd:cd16948    9 IIGQIVSNALKYSKqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPrvfdkgftgengrnfqESTGMGLYLVKKLCDKL 88

                         90       100
                 ....*....|....*....|.
gi 446529200 323 SGSVNIETKIGEGTNVTLNIP 343
Cdd:cd16948   89 GHKIDVESEVGEGTTFTITFP 109
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-343 1.40e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 40.73  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 276 EINVGIRQTGRHLVAEVIDAGNGFDP-----------SSK-PKGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIP 343
Cdd:cd16915   25 QVEVFLRDEGDDLVIEVRDTGPGIAPelrdkvfergvSTKgQGERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
PRK13557 PRK13557
histidine kinase; Provisional
 285-344 2.05e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 43.12  E-value: 2.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446529200 285 GRHLVAEVIDAGNGFDPSSKP-------------KGSGLGL---YGMnerAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:PRK13557 322 GRYVSIAVTDTGSGMPPEILArvmdpffttkeegKGTGLGLsmvYGF---AKQSGGAVRIYSEVGEGTTVRLYFPA 394
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 266-343 2.46e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 42.59  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 266 LNALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDP-----------SSKPKGSGLGLYGMNERAELVSGSVNIETKIGE 334
Cdd:PRK11086 446 LEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPdeidaifdkgySTKGSNRGVGLYLVKQSVENLGGSIAVESEPGV 525


                 ....*....
gi 446529200 335 GTNVTLNIP 343
Cdd:PRK11086 526 GTQFFVQIP 534
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 267-343 3.60e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 39.40  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 267 NALKYADVNEINV-----GIRQTGRHLVAEVIDAGNGFDP-----------------SSKPKGSGLGLYGMNERAELVSG 324
Cdd:cd16922   11 NAIKFTEEGEVTLrvsleEEEEDGVQLRFSVEDTGIGIPEeqqarlfepfsqadsstTRKYGGTGLGLAISKKLVELMGG 90

                         90
                 ....*....|....*....
gi 446529200 325 SVNIETKIGEGTNVTLNIP 343
Cdd:cd16922   91 DISVESEPGQGSTFTFTLP 109
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 250-343 3.71e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 40.09  E-value: 3.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 250 DSDIETVVYRVVQEAILNALKYA----DVNEINVGIRQTGRHLVAEVIDAGNGFD-PSSKPKGSGLGLYGMNERAELVSG 324
Cdd:cd16951   33 SSEVATAIGLVVNELLQNALKHAfsdrEGGTITIRSVVDGDYLRITVIDDGVGLPqDEDWPNKGSLGLQIVRSLVEGELK 112

                         90
                 ....*....|....*....
gi 446529200 325 SVNIETKIGEGTNVTLNIP 343
Cdd:cd16951  113 AFLEVQSAENGTRVNIDIP 131
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 2-344 3.76e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 42.27  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200   2 INEDSIQLDTLLKKYYEHSIEKIVFADDNGKIIAMNDAAKDILseedNYSaVANAICHRCEGYTNAYDVQSCKDCFLESM 81
Cdd:COG5809  132 MEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLL----GIS-IEELIGKSILELIHSDDQENVAAFISQLL 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200  82 QVQAT-NFQVFMKTKDQKVMPFTATYQLIDQDRGIHAFTlqNVSSQIEQQEKLhqQRMMRKTisaqenERKRISRELHDS 160
Cdd:COG5809  207 KDGGIaQGEVRFWTKDGRWRLLEASGAPIKKNGEVDGIV--IIFRDITERKKL--EELLRKS------EKLSVVGELAAG 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 161 VIQEMLNVDVQLR----LLKYQEDTTK------LLEDAENIEYIVAKLIDDIRNMSVELRPASLDDLgleaaFKSYFKQF 230
Cdd:COG5809  277 IAHEIRNPLTSLKgfiqLLKDTIDEEQktyldiMLSELDRIESIISEFLVLAKPQAIKYEPKDLNTL-----IEEVIPLL 351

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 231 EEN---YGIKIIYTSNIKntrfDSDIETVVYRVVQeAILNALKYA-----DVNEINVGIRQTGRHLVA-EVIDAGNG--- 298
Cdd:COG5809  352 QPQallKNVQIELELEDD----IPDILGDENQLKQ-VFINLLKNAieampEGGNITIETKAEDDDKVViSVTDEGCGipe 426

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446529200 299 ------FDP--SSKPKGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI 344
Cdd:COG5809  427 erlkklGEPfyTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
PRK15347 PRK15347
two component system sensor kinase;
267-344 8.80e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 41.17  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 267 NALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPK-------------GSGLGLYGMNERAELVSGSVNIETKIG 333
Cdd:PRK15347 524 NAVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQiftpfyqadthsqGTGLGLTIASSLAKMMGGELTLFSTPG 603

                         90
                 ....*....|.
gi 446529200 334 EGTNVTLNIPI 344
Cdd:PRK15347 604 VGSCFSLVLPL 614
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 254-342 1.09e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 38.21  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 254 ETVVYRVVQEAILNALKYA-DVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKG----------------SGLGLYGMN 316
Cdd:cd16975    2 TLLLSRALINIISNACQYApEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKAlelfyrddtsrrsgghYGMGLYIAK 81

                         90       100
                 ....*....|....*....|....*.
gi 446529200 317 ERAELVSGSVNIETKIGEGTNVTLNI 342
Cdd:cd16975   82 NLVEKHGGSLIIENSQKGGAEVTVKI 107
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 267-344 1.42e-03

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 40.21  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 267 NALKYADVN-EINVGIRQTGRHLVAEVIDAGNG---------FD-------PSSKPKGSGLGLYGMNERAELVSGSVNIE 329
Cdd:PRK11100 379 NAIDFSPEGgTITLSAEVDGEQVALSVEDQGPGipdyalpriFErfyslprPANGRKSTGLGLAFVREVARLHGGEVTLR 458

                         90
                 ....*....|....*
gi 446529200 330 TKIGEGTNVTLNIPI 344
Cdd:PRK11100 459 NRPEGGVLATLTLPR 473
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 259-344 2.16e-03

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 39.89  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 259 RVVQEAILNALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDP-------------SSKPKGSGLGLYGMNERAELVSGS 325
Cdd:PRK11466 564 QVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPaklaeifqpfvqvSGKRGGTGLGLTISSRLAQAMGGE 643

                         90
                 ....*....|....*....
gi 446529200 326 VNIETKIGEGTNVTLNIPI 344
Cdd:PRK11466 644 LSATSTPEVGSCFCLRLPL 662
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
187-344 4.51e-03

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 38.61  E-value: 4.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 187 DAENIEYIVAKLIDDIRNMSVELRPASLDDLgLEAAFKsYFKQFEENYGIKIIYTSNIKNTRFDSDIETVVyRVVQEAIL 266
Cdd:PRK10364 282 EADRLNRVVSELLELVKPTHLALQAVDLNDL-INHSLQ-LVSQDANSREIQLRFTANDTLPEIQADPDRLT-QVLLNLYL 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446529200 267 NALKYADVN-EINVGIRQTGRHLVAEVIDAGNG---------FDP--SSKPKGSGLGLYGMNERAELVSGSVNIETKIGE 334
Cdd:PRK10364 359 NAIQAIGQHgVISVTASESGAGVKISVTDSGKGiaadqleaiFTPyfTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGK 438

                        170
                 ....*....|
gi 446529200 335 GTNVTLNIPI 344
Cdd:PRK10364 439 GATFTLWLPV 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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