|
Name |
Accession |
Description |
Interval |
E-value |
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
10-430 |
3.53e-133 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 391.36 E-value: 3.53e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLNTDH-DRtnaVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:COG0305 1 NIEAEQAVLGALLLDNDAlDE---VADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AEMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPaDMTATDRITAVQQVIGQVAEHsrtGHKGGLRPASEV 167
Cdd:COG0305 78 AELAENVPSAANIEyYARIVKEKALLRRLIEAGTEIVELAYDE-DEDVDELLDEAEQKIFEIAEK---RSSKGFVSISDI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 168 VDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFSLEM 246
Cdd:COG0305 154 LKEALERIEELYKNGGGITGVPTGFTDLDKLTGGLQ--PGDLIILAARPSMGKTAfALN-IARNAAIKEGKPVAIFSLEM 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 247 TDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGLVAIDY 326
Cdd:COG0305 231 SAEQLVMRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDY 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 327 LTLMKTES-AERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVY 405
Cdd:COG0305 310 LQLMSGSGrSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYY 389
|
410 420
....*....|....*....|....*.
gi 446531976 406 NENAD-PNLMEMLLRLNREGPSGTAY 430
Cdd:COG0305 390 NPDSEdKGIAEIIIAKQRNGPTGTVK 415
|
|
| phage_DnaB |
TIGR03600 |
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ... |
10-432 |
1.14e-126 |
|
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]
Pssm-ID: 274672 [Multi-domain] Cd Length: 420 Bit Score: 374.43 E-value: 1.14e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYLA 89
Cdd:TIGR03600 1 SIEAEQAVLGGLLL--DNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVGGLAYLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 90 EMSKAAIP-ASMVNYAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAehSRTGHKGGLRPASEVV 168
Cdd:TIGR03600 79 EISNNTPSaANISSYARIVREKAKERKLIAACQRIITLACSPDGGTAEQKVEEAQAALLALT--MSDGQEDGFVTFGEVL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 169 DDWIDDLERRFNDPAHAAGLTLGIESLDRLMapkQALR-GSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEMT 247
Cdd:TIGR03600 157 EDVVRDLDKRFNPKGELTGLSTGLPKLDRLT---NGLVkGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 248 DRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAIDYL 327
Cdd:TIGR03600 234 AEQLGERLLASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKGGLDLIVVDYI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 328 TLMKTESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYNE 407
Cdd:TIGR03600 314 QLMAPARGRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDA 393
|
410 420
....*....|....*....|....*.
gi 446531976 408 NADP-NLMEMLLRLNREGPSGTAYAL 432
Cdd:TIGR03600 394 REPPaGIAELILAKNRHGPTGTVELL 419
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
7-428 |
7.31e-99 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 303.47 E-value: 7.31e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 7 ALYSVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFA 86
Cdd:NF040583 1 GPYSVEAEQSVLGGLML--DNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLITLSESLEQQGQLEQVGGFA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 87 YLAEMSKAAiP--ASMVNYAKIVREKAILRYAVeKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEHSRTGHKGGLrpa 164
Cdd:NF040583 79 YLAELSKNT-PsaANIVAYAEIVAEYSRARQLL-ALGHDLSADASAPRADIADLLEQAEQRLFDIAEQAEPQQEVTL--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 165 SEVVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQAlrGSLVVIGARPKMGKTAAFNKIAVHfALNHR--LPTLVF 242
Cdd:NF040583 154 IEGLETLVSELELRCQSGNGITGTPTGFAELDEMTCGLQP--GDLILLAARPSMGKTALALAFCLG-ALRGKpdKVVQIY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 243 SLEMTDRSLIERMVAQEAKVNSEIFYLGP-NDE--SELSLAIAKAGEIaESNMMIDSTAGVTLAHIVAECRKVKRMRGSV 319
Cdd:NF040583 231 SLEMPTEQLLMRLVSMLGRVPLQRLRSGLlDDEdwARISQAMALLTDW-KDRLIIDDTSYLTPALLRARARRNARKYGKP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 320 GLVAIDYLTLMKTESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGL 399
Cdd:NF040583 310 SLIMVDYLQLMRCPGQENRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFI 389
|
410 420 430
....*....|....*....|....*....|
gi 446531976 400 YRDAVYNEN-ADPNLMEMLLRLNREGPSGT 428
Cdd:NF040583 390 YRDEVYNPNtPDKGIAEIIIGKQRQGPTGT 419
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
10-428 |
3.29e-97 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 299.95 E-value: 3.29e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYLA 89
Cdd:PRK05748 13 SIEAEQAVLGAIFL--DPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEEVGGLSYLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 90 EMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPADmTATDRITAVQQVIGQVAEHSrtgHKGGLRPASEVV 168
Cdd:PRK05748 91 ELANSVPTAANIEyYAKIVAEKAMLRRLIRTATEIANDAYEPED-DADEILDEAEKKIFEVSERR---NKSGFKNIKDVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 169 DDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFSLEMT 247
Cdd:PRK05748 167 VKAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQ--PNDLIIVAARPSVGKTAfALN-IAQNVATKTDKNVAIFSLEMG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 248 DRSLIERMVAQEAKVNSEIF---YLGPNDESELSLAIakaGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAI 324
Cdd:PRK05748 244 AESLVMRMLCAEGNIDAQRLrtgQLTDDDWPKLTIAM---GSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGLGLILI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 325 DYLTLMKT--ESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRD 402
Cdd:PRK05748 321 DYLQLIQGsgRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRD 400
|
410 420
....*....|....*....|....*..
gi 446531976 403 AVYNENADP-NLMEMLLRLNREGPSGT 428
Cdd:PRK05748 401 DYYDEETENkNTIEIIIAKQRNGPVGT 427
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
187-430 |
9.94e-87 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 266.30 E-value: 9.94e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 187 GLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEMTDRSLIERMVAQEAKVNSEI 266
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQ--PGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 267 FYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAIDYLTLMKTES-AERRDIAYGDI 345
Cdd:cd00984 79 LRTGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKrAENRQQEVAEI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 346 TTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYN-ENADPNLMEMLLRLNREG 424
Cdd:cd00984 159 SRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDkDSEDKGIAEIIIAKNRNG 238
|
....*.
gi 446531976 425 PSGTAY 430
Cdd:cd00984 239 PTGTVY 244
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
187-428 |
1.75e-76 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 239.63 E-value: 1.75e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 187 GLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFSLEMTDRSLIERMVAQEAKVNSE 265
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQ--PGDLIIIAARPSMGKTAfALN-IARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 266 IFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGLVAIDYLTLMK-TESAERRDIAYGD 344
Cdd:pfam03796 78 KLRTGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSgGSRGENRQQEISE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 345 ITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYNENADPNLMEMLLRLNREG 424
Cdd:pfam03796 157 ISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNG 236
|
....
gi 446531976 425 PSGT 428
Cdd:pfam03796 237 PTGT 240
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
10-430 |
3.53e-133 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 391.36 E-value: 3.53e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLNTDH-DRtnaVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:COG0305 1 NIEAEQAVLGALLLDNDAlDE---VADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AEMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPaDMTATDRITAVQQVIGQVAEHsrtGHKGGLRPASEV 167
Cdd:COG0305 78 AELAENVPSAANIEyYARIVKEKALLRRLIEAGTEIVELAYDE-DEDVDELLDEAEQKIFEIAEK---RSSKGFVSISDI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 168 VDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFSLEM 246
Cdd:COG0305 154 LKEALERIEELYKNGGGITGVPTGFTDLDKLTGGLQ--PGDLIILAARPSMGKTAfALN-IARNAAIKEGKPVAIFSLEM 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 247 TDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGLVAIDY 326
Cdd:COG0305 231 SAEQLVMRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDY 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 327 LTLMKTES-AERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVY 405
Cdd:COG0305 310 LQLMSGSGrSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYY 389
|
410 420
....*....|....*....|....*.
gi 446531976 406 NENAD-PNLMEMLLRLNREGPSGTAY 430
Cdd:COG0305 390 NPDSEdKGIAEIIIAKQRNGPTGTVK 415
|
|
| phage_DnaB |
TIGR03600 |
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ... |
10-432 |
1.14e-126 |
|
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]
Pssm-ID: 274672 [Multi-domain] Cd Length: 420 Bit Score: 374.43 E-value: 1.14e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYLA 89
Cdd:TIGR03600 1 SIEAEQAVLGGLLL--DNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVGGLAYLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 90 EMSKAAIP-ASMVNYAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAehSRTGHKGGLRPASEVV 168
Cdd:TIGR03600 79 EISNNTPSaANISSYARIVREKAKERKLIAACQRIITLACSPDGGTAEQKVEEAQAALLALT--MSDGQEDGFVTFGEVL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 169 DDWIDDLERRFNDPAHAAGLTLGIESLDRLMapkQALR-GSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEMT 247
Cdd:TIGR03600 157 EDVVRDLDKRFNPKGELTGLSTGLPKLDRLT---NGLVkGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 248 DRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAIDYL 327
Cdd:TIGR03600 234 AEQLGERLLASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKGGLDLIVVDYI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 328 TLMKTESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYNE 407
Cdd:TIGR03600 314 QLMAPARGRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDA 393
|
410 420
....*....|....*....|....*.
gi 446531976 408 NADP-NLMEMLLRLNREGPSGTAYAL 432
Cdd:TIGR03600 394 REPPaGIAELILAKNRHGPTGTVELL 419
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
9-428 |
1.99e-109 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 330.54 E-value: 1.99e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLMLNTDHdrTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:TIGR00665 3 HNIEAEQAVLGAILLDNEA--IDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AEMSKAAIPASMVN-YAKIVREKAILRyaveKLNSCLEIMIQPA---DMTATDRITAVQQVIGQVAEHSrtgHKGGLRPA 164
Cdd:TIGR00665 81 AELASNVPSAANIEyYAEIVKEKAILR----RLIQAGTEIVELAydpTGDVEELLDEAEQKIFEIAESR---TSKGFKSI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 165 SEVVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFS 243
Cdd:TIGR00665 154 KEILKEAVEEIEELYERKGGITGVPTGFTDLDKLTSGLQ--PSDLIILAARPSMGKTAfALN-IAENAAIKEGKPVAFFS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 244 LEMTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGLVA 323
Cdd:TIGR00665 231 LEMSAEQLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHG-LGLIV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 324 IDYLTLMK-TESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRD 402
Cdd:TIGR00665 310 IDYLQLMSgSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRD 389
|
410 420
....*....|....*....|....*..
gi 446531976 403 AVYN-ENADPNLMEMLLRLNREGPSGT 428
Cdd:TIGR00665 390 EYYNpDSEDKGIAEIIIAKQRNGPTGT 416
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
7-428 |
7.31e-99 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 303.47 E-value: 7.31e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 7 ALYSVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFA 86
Cdd:NF040583 1 GPYSVEAEQSVLGGLML--DNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLITLSESLEQQGQLEQVGGFA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 87 YLAEMSKAAiP--ASMVNYAKIVREKAILRYAVeKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEHSRTGHKGGLrpa 164
Cdd:NF040583 79 YLAELSKNT-PsaANIVAYAEIVAEYSRARQLL-ALGHDLSADASAPRADIADLLEQAEQRLFDIAEQAEPQQEVTL--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 165 SEVVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQAlrGSLVVIGARPKMGKTAAFNKIAVHfALNHR--LPTLVF 242
Cdd:NF040583 154 IEGLETLVSELELRCQSGNGITGTPTGFAELDEMTCGLQP--GDLILLAARPSMGKTALALAFCLG-ALRGKpdKVVQIY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 243 SLEMTDRSLIERMVAQEAKVNSEIFYLGP-NDE--SELSLAIAKAGEIaESNMMIDSTAGVTLAHIVAECRKVKRMRGSV 319
Cdd:NF040583 231 SLEMPTEQLLMRLVSMLGRVPLQRLRSGLlDDEdwARISQAMALLTDW-KDRLIIDDTSYLTPALLRARARRNARKYGKP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 320 GLVAIDYLTLMKTESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGL 399
Cdd:NF040583 310 SLIMVDYLQLMRCPGQENRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFI 389
|
410 420 430
....*....|....*....|....*....|
gi 446531976 400 YRDAVYNEN-ADPNLMEMLLRLNREGPSGT 428
Cdd:NF040583 390 YRDEVYNPNtPDKGIAEIIIGKQRQGPTGT 419
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
10-428 |
3.29e-97 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 299.95 E-value: 3.29e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYLA 89
Cdd:PRK05748 13 SIEAEQAVLGAIFL--DPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEEVGGLSYLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 90 EMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPADmTATDRITAVQQVIGQVAEHSrtgHKGGLRPASEVV 168
Cdd:PRK05748 91 ELANSVPTAANIEyYAKIVAEKAMLRRLIRTATEIANDAYEPED-DADEILDEAEKKIFEVSERR---NKSGFKNIKDVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 169 DDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFSLEMT 247
Cdd:PRK05748 167 VKAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQ--PNDLIIVAARPSVGKTAfALN-IAQNVATKTDKNVAIFSLEMG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 248 DRSLIERMVAQEAKVNSEIF---YLGPNDESELSLAIakaGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAI 324
Cdd:PRK05748 244 AESLVMRMLCAEGNIDAQRLrtgQLTDDDWPKLTIAM---GSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGLGLILI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 325 DYLTLMKT--ESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRD 402
Cdd:PRK05748 321 DYLQLIQGsgRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRD 400
|
410 420
....*....|....*....|....*..
gi 446531976 403 AVYNENADP-NLMEMLLRLNREGPSGT 428
Cdd:PRK05748 401 DYYDEETENkNTIEIIIAKQRNGPVGT 427
|
|
| PRK08006 |
PRK08006 |
replicative DNA helicase DnaB; |
9-428 |
7.13e-87 |
|
replicative DNA helicase DnaB;
Pssm-ID: 181193 [Multi-domain] Cd Length: 471 Bit Score: 273.81 E-value: 7.13e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:PRK08006 29 HSIEAEQSVLGGLML--DNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AEMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEhSRTGHKGGLRPASEV 167
Cdd:PRK08006 107 AELSKNTPSAANISaYADIVRERAVVREMISVANEIADAGYDPQGRTSEDLLDLAESRVFQIAE-SRANKDEGPKNIADI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 168 VDDWIDDLERRFNDPAHA-AGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEM 246
Cdd:PRK08006 186 LDATVARIEQLFQQPHDGvTGVNTGYDDLNKKTAGLQ--PSDLIIVAARPSMGKTTFAMNLCENAAMLQDKPVLIFSLEM 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 247 TDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAES-NMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAID 325
Cdd:PRK08006 264 PGEQIMMRMLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKrNMYIDDSSGLTPTEVRSRARRIFREHGGLSLIMID 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 326 YLTLMKTES-AERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAV 404
Cdd:PRK08006 344 YLQLMRVPSlSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEV 423
|
410 420
....*....|....*....|....*
gi 446531976 405 YNENAD-PNLMEMLLRLNREGPSGT 428
Cdd:PRK08006 424 YHENSDlKGIAEIIIGKQRNGPIGT 448
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
187-430 |
9.94e-87 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 266.30 E-value: 9.94e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 187 GLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEMTDRSLIERMVAQEAKVNSEI 266
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQ--PGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 267 FYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAIDYLTLMKTES-AERRDIAYGDI 345
Cdd:cd00984 79 LRTGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKrAENRQQEVAEI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 346 TTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYN-ENADPNLMEMLLRLNREG 424
Cdd:cd00984 159 SRSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDkDSEDKGIAEIIIAKNRNG 238
|
....*.
gi 446531976 425 PSGTAY 430
Cdd:cd00984 239 PTGTVY 244
|
|
| PRK06904 |
PRK06904 |
replicative DNA helicase; Validated |
5-428 |
4.88e-84 |
|
replicative DNA helicase; Validated
Pssm-ID: 136106 [Multi-domain] Cd Length: 472 Bit Score: 266.86 E-value: 4.88e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 5 AIALYSVDAEQAVLGCLMLNTDHdrTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGG 84
Cdd:PRK06904 21 LIPPHSIEAEQAVLGGIMLDNRH--WDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLLTLDQALKTKGKSDEVGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 85 FAYLAEMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEhSRTGHKGGLRP 163
Cdd:PRK06904 99 FAYLAELSNNTPSAANILaYADIVREKAILRELISVGNNIAKNAYSPKGQDIKDILDEAERDVFSIAE-KRTTANEGPQN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 164 ASEVVDDWIDDLERRFNDPAHAA--GLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLV 241
Cdd:PRK06904 178 VINLLENTIDKIENLAATPTNNGvtGVTTGFTDLDKKTAGLQ--PSDLIIVAARPSMGKTTFAMNLCENAAMASEKPVLV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 242 FSLEMTDRSLIERMVAQEAKVNSEIFYLGPN-DESELSLAIAKAGEIAE-SNMMIDSTAGVTLAHIVAECRKVKRMRGSV 319
Cdd:PRK06904 256 FSLEMPAEQIMMRMLASLSRVDQTKIRTGQNlDQQDWAKISSTVGMFKQkPNLYIDDSSGLTPTELRSRARRVYRENGGL 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 320 GLVAIDYLTLMKTES-AERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIG 398
Cdd:PRK06904 336 SLIMVDYLQLMRAPGfEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESGSIEQDADLIMF 415
|
410 420 430
....*....|....*....|....*....|..
gi 446531976 399 LYRDAVYNENADPN--LMEMLLRLNREGPSGT 428
Cdd:PRK06904 416 IYRDEVYNETTEDNkgVAEIIIGKQRNGPIGR 447
|
|
| PRK08840 |
PRK08840 |
replicative DNA helicase; Provisional |
9-428 |
2.31e-78 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181562 [Multi-domain] Cd Length: 464 Bit Score: 251.83 E-value: 2.31e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:PRK08840 22 HSLEAEQSVIGGLLL--DNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEHLERREQLEDVGGFAYL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AEMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEhSRTGHKGGLRPASEV 167
Cdd:PRK08840 100 ADLAKNTPSAANINaYADIVAERALVRNLIGVANEIADAGYDPQGRTSEDLLDMAESKVFAIAE-ARTSENEGPQNVDSI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 168 VDDWIDDLERRFNDPAHA-AGLTLGIESLDRLMApkqALRGS-LVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLE 245
Cdd:PRK08840 179 LEKTLERIELLYKTPQDGvTGVDTGFTDLNKKTA---GLQGSdLIIVAARPSMGKTTFAMNLCENAAMDQDKPVLIFSLE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 246 MTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAES-NMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAI 324
Cdd:PRK08840 256 MPAEQLMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKkNMYIDDSSGLTPTEVRSRARRIAREHGGLSMIMV 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 325 DYLTLMKTES-AERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDA 403
Cdd:PRK08840 336 DYLQLMRVPAlSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDE 415
|
410 420
....*....|....*....|....*.
gi 446531976 404 VYN-ENADPNLMEMLLRLNREGPSGT 428
Cdd:PRK08840 416 VYNpDSPLKGTAEIIIGKQRNGPIGS 441
|
|
| PRK08760 |
PRK08760 |
replicative DNA helicase; Provisional |
9-428 |
3.16e-78 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181547 [Multi-domain] Cd Length: 476 Bit Score: 251.76 E-value: 3.16e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLMLNTD-HDRTNAvfaLLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAY 87
Cdd:PRK08760 35 HSVEAEQAVLGGLMLAPDaLDRVND---QLTENDFYRRDHRLIYRAIRELSEKDRPFDAVTLGEWFESQGKLEQVGDGAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 88 LAEM-SKAAIPASMVNYAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAE------HSRTGHKGG 160
Cdd:PRK08760 112 LIELaSTTPSAANIAAYAEIVRDKAVLRQLIEVGTTIVNDGFQPEGRESIELLASAEKAVFKIAEagargrTDFVAMPGA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 161 LRPASEvvddwidDLERRFNDPAHAAGLTLGIESLDRLMAPKQALrgSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTL 240
Cdd:PRK08760 192 LKDAFE-------ELRNRFENGGNITGLPTGYNDFDAMTAGLQPT--DLIILAARPAMGKTTFALNIAEYAAIKSKKGVA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 241 VFSLEMTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRgSVG 320
Cdd:PRK08760 263 VFSMEMSASQLAMRLISSNGRINAQRLRTGALEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLKREH-DLG 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 321 LVAIDYLTLMKTE-SAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGL 399
Cdd:PRK08760 342 LIVIDYLQLMSVPgNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMIVFI 421
|
410 420 430
....*....|....*....|....*....|.
gi 446531976 400 YRDAVYNENADPN--LMEMLLRLNREGPSGT 428
Cdd:PRK08760 422 YRDDYYNKENSPDkgLAEIIIGKHRGGPTGS 452
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
187-428 |
1.75e-76 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 239.63 E-value: 1.75e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 187 GLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTA-AFNkIAVHFALNHRLPTLVFSLEMTDRSLIERMVAQEAKVNSE 265
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQ--PGDLIIIAARPSMGKTAfALN-IARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 266 IFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGLVAIDYLTLMK-TESAERRDIAYGD 344
Cdd:pfam03796 78 KLRTGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSgGSRGENRQQEISE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 345 ITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYNENADPNLMEMLLRLNREG 424
Cdd:pfam03796 157 ISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNG 236
|
....
gi 446531976 425 PSGT 428
Cdd:pfam03796 237 PTGT 240
|
|
| PRK05595 |
PRK05595 |
replicative DNA helicase; Provisional |
10-429 |
9.61e-76 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235525 [Multi-domain] Cd Length: 444 Bit Score: 244.35 E-value: 9.61e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 10 SVDAEQAVLGCLMLntdhDRTNAVFAL--LKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAY 87
Cdd:PRK05595 11 SIEAEQSVLGAMII----DKTSIAEAAevLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLKSTDKLEAAGGVTY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 88 LAEMSKAAIP-ASMVNYAKIVREKAILRYAVEKLNSCLEIMIQPADMTAtDRITAVQQVIGQVAEHSRTGHkggLRPASE 166
Cdd:PRK05595 87 ITELSNSIVStANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNNQDDVE-KVIDSAEKKIFDISEKRTTSD---FEPLSN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 167 VVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEM 246
Cdd:PRK05595 163 VLERGFEQIENLFNNKGETTGVASGFRELDAKTSGFQ--KGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSLEM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 247 TDRSLIERMVAQEAKVNSEIFYLGpNDESELSLAIAKA-GEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGLVAID 325
Cdd:PRK05595 241 SKEQLAYKLLCSEANVDMLRLRTG-NLEDKDWENIARAsGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEHG-IDMILID 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 326 YLTLMK-TESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAV 404
Cdd:PRK05595 319 YLQLMSgGKGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEY 398
|
410 420
....*....|....*....|....*.
gi 446531976 405 YN-ENADPNLMEMLLRLNREGPSGTA 429
Cdd:PRK05595 399 YNkETEDKNVAECIIAKQRNGPTGTV 424
|
|
| PRK07004 |
PRK07004 |
replicative DNA helicase; Provisional |
9-428 |
1.11e-73 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235907 [Multi-domain] Cd Length: 460 Bit Score: 239.43 E-value: 1.11e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLML-NTDHDRtnaVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAY 87
Cdd:PRK07004 17 HSIEAEQSVLGGLLLdNAAWDR---IADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVYEALTTSGKAEEVGGLAY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 88 LAEMSKAAIPASMVN-YAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEHSRTGHKG--GLRPA 164
Cdd:PRK07004 94 LNALAQNTPSAANIRrYAEIVRDRAVLRRLVSVADEISADAFNPQGKEVRQLLDEAESKVFSIAEEGARGTQGflEIGPL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 165 SEVVDDWIDDLERRfNDPAHAAGLTLGIESLDRLMAPKQAlrGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSL 244
Cdd:PRK07004 174 LTQVVERIDTLYHT-ANPSDVTGTPTGFVDLDRMTSGMHG--GELIIVAGRPSMGKTAFSMNIGEYVAVEYGLPVAVFSM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 245 EMTDRSLIERMVAQEAKVNSEIFYLG---PNDESELSLAIAKageIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGL 321
Cdd:PRK07004 251 EMPGTQLAMRMLGSVGRLDQHRMRTGrltDEDWPKLTHAVQK---MSEAQLFIDETGGLNPMELRSRARRLARQCGKLGL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 322 VAIDYLTLMKTESA-ERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLY 400
Cdd:PRK07004 328 IIIDYLQLMSGSSQgENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADVILFIY 407
|
410 420
....*....|....*....|....*....
gi 446531976 401 RDAVYN-ENADPNLMEMLLRLNREGPSGT 428
Cdd:PRK07004 408 RDEVYNpDSPDKGTAEIIIGKQRNGPIGP 436
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
11-387 |
1.61e-71 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 243.12 E-value: 1.61e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 11 VDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYLAE 90
Cdd:PRK07773 28 LAAEQSVLGGMLL--SKEAIARVLERLRPGAFYRPAHQNIYDAILDLYGRGEPADLVTVAAELDRRGLLERIGGAPYLHT 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 91 MSKAAIPASMVN-YAKIVREKAILRYAVEKLNsclEIMiQPADMTATDRITAVQQVIGQVAEHSRTGHKGGLRPASEVVD 169
Cdd:PRK07773 106 LISTVPTAANADyYARIVAEKALLRRLIEAGT---RIV-QYGYAEGADVAEVVDRAQAEIYDVTDRRLSEDFVALEDLLQ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 170 DWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEMTDR 249
Cdd:PRK07773 182 PTFDEIDAIASSGGLARGVPTGFTELDAMTNGLH--PGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEMSKE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 250 SLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRmRGSVGLVAIDYLTL 329
Cdd:PRK07773 260 QLVMRLLSAEAKIKLSDMRSGRMSDDDWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQ-EANLGLIVVDYLQL 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446531976 330 MKT-ESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTG 387
Cdd:PRK07773 339 MTSgKKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESG 397
|
|
| PRK09165 |
PRK09165 |
replicative DNA helicase; Provisional |
9-428 |
2.01e-68 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181676 [Multi-domain] Cd Length: 497 Bit Score: 226.69 E-value: 2.01e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLMlnTDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:PRK09165 23 HNIEAEQALLGAIL--INNRALDRVSDFLKPEHFFEPLHQRIYEAIAKIIRKGKLATPVTLKTFLENDEALGELGGVQYL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AEMSKAAIPASMVN-YAKIVREKAILRYAVE--------KLNScleimiqPADMTATDRITAVQQVIGQVAEHSRTGhkG 159
Cdd:PRK09165 101 AKLATEAVTIINARdYGRIIYDLALRRELINigedvvnnAYDA-------PVDVAPQEQIEDAEQKLYELAETGRYE--G 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 160 GLRPASEVVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRLPT 239
Cdd:PRK09165 172 GFQSFGTAITEAVDMANAAFKRDGHLSGISTGLRDLDSKLGGLH--PSDLIILAGRPSMGKTALATNIAFNAAKAYRREA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 240 L--------------VFSLEMTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHI 305
Cdd:PRK09165 250 QpdgskkavnggvvgFFSLEMSAEQLATRILSEQSEISSSKIRRGKISEEDFEKLVDASQELQKLPLYIDDTPALSISQL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 306 VAECRKVKRMRGsVGLVAIDYLTLMKTESAERRD-----IAygDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNP 380
Cdd:PRK09165 330 RARARRLKRQHG-LDLLVVDYLQLIRGSSKRSSDnrvqeIS--EITQGLKALAKELNIPVIALSQLSRQVEQRDDKRPQL 406
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446531976 381 SDSKDTGQIEQDCDVWIGLYRDAVYNENADP------------------NLMEMLLRLNREGPSGT 428
Cdd:PRK09165 407 SDLRESGSIEQDADVVMFVYREEYYLKRKEPregtpkheewqekmekvhNKAEVIIAKQRHGPTGT 472
|
|
| PRK06321 |
PRK06321 |
replicative DNA helicase; Provisional |
6-428 |
8.91e-57 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180528 [Multi-domain] Cd Length: 472 Bit Score: 195.06 E-value: 8.91e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 6 IALYSVDAEQAVLGCLMLNTDHdrTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGF 85
Cdd:PRK06321 15 SPPNSKESEMIVLGCMLTSVNY--LNLAANQLQEDDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQLNVIGGP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 86 AYLAEMSK-AAIPASMVNYAKIVREKAILR------YAVEKlnSCLEimiQPADM-TATDRITAVQQVIGQ---VAEHSR 154
Cdd:PRK06321 93 SYLITLAEfAGTSAYIEEYAEIIRSKSILRkmiqtaKEIEK--KALE---EPKDVaTALDEAQNLLFKISQttnLAQYVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 155 TGHK-GGLRPASEVvdDWIDDLERR---FNDPAH---AAGLTlGIES----LDRLMapkQALRGS-LVVIGARPKMGKTA 222
Cdd:PRK06321 168 VADKlKGLTSSKDK--PFLLQLQERqeaFQQSAQgdsSPMIS-GIPThfidLDKMI---NGFSPSnLMILAARPAMGKTA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 223 AFNKIAVHFALNHRLPTLVFSLEMTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTL 302
Cdd:PRK06321 242 LALNIAENFCFQNRLPVGIFSLEMTVDQLIHRIICSRSEVESKKISVGDLSGRDFQRIVSVVNEMQEHTLLIDDQPGLKI 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 303 AHIVAECRKVKRMRGsVGLVAIDYLTLMK----TESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRP 378
Cdd:PRK06321 322 TDLRARARRMKESYD-IQFLIIDYLQLLSgsgnLRNSESRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRP 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 446531976 379 NPSDSKDTGQIEQDCDVWIGLYRDAVYNENADPNLMEMLLRLNREGPSGT 428
Cdd:PRK06321 401 MMSDLRESGSIEQDSDLVMFLLRREYYDPNDKPGTAELIVAKNRHGSIGS 450
|
|
| PRK05636 |
PRK05636 |
replicative DNA helicase; Provisional |
9-428 |
6.65e-56 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180177 [Multi-domain] Cd Length: 505 Bit Score: 193.52 E-value: 6.65e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 9 YSVDAEQAVLGCLMLNTDhdRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFAYL 88
Cdd:PRK05636 72 YDNEAEQGVLGAMLLSPD--TVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVIVAGRLDRTNDLERVGGAPYL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 89 AE-MSKAAIPASMVNYAKIVREKAILRYAVEKLNSCLEIMIQPADMTATDR-ITAVQQVIGQVAEHSRTGHKGGLrpaSE 166
Cdd:PRK05636 150 HTlIQSVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYEGDEGAEIDSvIDRAQQEVFAVSQKNQSEDYAVL---AD 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 167 VVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMapkQALR-GSLVVIGARPKMGKTAafnkIAVHF----ALNHRLPTLV 241
Cdd:PRK05636 227 ILDPTMDELEMLSSQGGIATGIPTGFKDLDDLT---NGLRgGQMIIVAARPGVGKST----LALDFmrsaSIKHNKASVI 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 242 FSLEMTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGsVGL 321
Cdd:PRK05636 300 FSLEMSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLKQKHD-LKL 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 322 VAIDYLTLMKT-ESAERRDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLY 400
Cdd:PRK05636 379 IVVDYLQLMSSgKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLY 458
|
410 420
....*....|....*....|....*....
gi 446531976 401 R-DAVYNENADPNLMEMLLRLNREGPSGT 428
Cdd:PRK05636 459 RpDSQDKDDERAGEADIILAKHRGGPIDT 487
|
|
| PRK08506 |
PRK08506 |
replicative DNA helicase; Provisional |
8-430 |
1.30e-55 |
|
replicative DNA helicase; Provisional
Pssm-ID: 236278 [Multi-domain] Cd Length: 472 Bit Score: 192.15 E-value: 1.30e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 8 LYSVDAEQAVL-GCLMlntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGFA 86
Cdd:PRK08506 4 LYDLDIERAVLsSILF---SPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKLPKDKKIDEEILLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 87 YLAEMSKAAIPAsmvnYAKIVREKAILRYAVeKLNSCLEIMIQPADMTATDRITAVQQVIGQVAEHSRTGhkgGLRPASE 166
Cdd:PRK08506 81 ILATNPIDNIEA----YVEEIKEKSIKRELL-SLANTIPEQAVEEDQKSSDILDEVERELYSITNGSNSE---DFKDSKE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 167 VVDDWIDDLERRFN-DPAHAAGLTLGIESLDRLMapKQALRGSLVVIGARPKMGKTAAFNKIAVHfALNHRLPTLVFSLE 245
Cdd:PRK08506 153 VIESTMEHIKKQKRlGNKDIIGLDTGFVELNKMT--KGFNKGDLIIIAARPSMGKTTLCLNMALK-ALNQDKGVAFFSLE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 246 MTDRSLIERMVAQEAKVNSEIFYLGPNDESELSLAIAKAGEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSVGLVAID 325
Cdd:PRK08506 230 MPAEQLMLRMLSAKTSIPLQNLRTGDLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAVID 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 326 YLTLMKTESAER-RDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVWIGLYRDAV 404
Cdd:PRK08506 310 YLQLMSGSGNFKdRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDV 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 446531976 405 YNENAD-------------------PNLM----EMLLRLNREGPSGTAY 430
Cdd:PRK08506 390 YKEREEkekekkakkegkeerrihfQNKSieeaEIIIGKNRNGPTGTVK 438
|
|
| PRK06749 |
PRK06749 |
replicative DNA helicase; Provisional |
6-428 |
4.31e-52 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168658 [Multi-domain] Cd Length: 428 Bit Score: 181.69 E-value: 4.31e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 6 IALYSVDAEQAVLGCLMLNTDHDRTnavfALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLyERVGGF 85
Cdd:PRK06749 1 MSIQNVEAEKTVLGSLLLDGELIKE----CRLTEQYFSMPVHKSIFQLMRKMEDEGQPIDLVTFTSRVDPNFL-KGIGGM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 86 AYLAEMSKAAIPASMVNYAK-IVREKAILRYAVEKLNSCLEIMIQPADMTAtdritaVQQVIGQVAEHSRTGHKGGLrpa 164
Cdd:PRK06749 76 EYFIGLMDGVPTTSNFSYYEgLVRGAWKMYQAGVLGHKMGERLIAEKSEKI------IGETITALCELEEKDCVCEF--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 165 sEVVDDWIDDLERRFNDPAHAAGLTLGIESLDRLMAPKQalRGSLVVIGARPKMGKTAAFNKIAVHFALNHRlPTLVFSL 244
Cdd:PRK06749 147 -DLKDALVDLYEELHQDAKEITGIETGYTSLNKMTCGLQ--EGDFVVLGARPSMGKTAFALNVGLHAAKSGA-AVGLFSL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 245 EMTDRSLIERMVAQEAKVNSEIFylgPNDESELSLA----IAKA-GEIAESNMMIDSTAGVTLAHIVAECRKVKRMRGSV 319
Cdd:PRK06749 223 EMSSKQLLKRMASCVGEVSGGRL---KNPKHRFAMEdwekVSKAfAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDK 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 320 G-LVAIDYLTLMKTESAER--RDIAYGDITTGLKNLAKELDCVVVLLTQLNRKLEERADKRPNPSDSKDTGQIEQDCDVW 396
Cdd:PRK06749 300 KiLIIVDYLQLITGDPKHKgnRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVI 379
|
410 420 430
....*....|....*....|....*....|...
gi 446531976 397 IGLYRDAVYN-ENADPNLMEMLLRLNREGPSGT 428
Cdd:PRK06749 380 MLMYREDYYDkETMQKEMTEIHVAKHRNGPVGS 412
|
|
| DnaB |
pfam00772 |
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
6-109 |
1.42e-27 |
|
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.
Pssm-ID: 395624 [Multi-domain] Cd Length: 103 Bit Score: 105.78 E-value: 1.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 6 IALYSVDAEQAVLGCLMLntDHDRTNAVFALLKPETFYINAHQVIYREIKGLFQADKPTDLITLTELMESKGLYERVGGF 85
Cdd:pfam00772 1 VPPHNIEAEQAVLGALLL--DPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVGGI 78
|
90 100
....*....|....*....|....*
gi 446531976 86 AYLAEMSKAA-IPASMVNYAKIVRE 109
Cdd:pfam00772 79 AYLAELAANVpSAANIEYYARIVKE 103
|
|
| RecA-like_Gp4D_helicase |
cd19483 |
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ... |
210-430 |
8.23e-16 |
|
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410891 [Multi-domain] Cd Length: 231 Bit Score: 76.45 E-value: 8.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 210 VVIGARPKMGKTAAFNKIAVHFALNHRLPTLVFSLEMTDRSLIERMVAQEAKVNSEIFYLGPnDESELSLAIAKAGEIAE 289
Cdd:cd19483 1 VTIGAGSGIGKSTIVRELAYHLITEHGEKVGIISLEESVEETAKGLAGKHLGKPEPLELPRD-DITEEEEDDAFDNELGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 290 SNM-MIDSTAGVTLAHIVAecrKVKRMRGSVG--LVAIDYLTLMK---TESAERRDIAygDITTGLKNLAKELDCVVVLL 363
Cdd:cd19483 80 GRFfLYDHFGSLDWDNLKE---KIRYMVKVLGckVIVLDHLTILVsglDSSDERKELD--EIMTELAALVKELGVTIILV 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446531976 364 TQLNR-----KLEEraDKRPNPSDSKDTGQIEQDCDVWIGLYRDAVYNENADPNLMEMLLRLNRE----GPSGTAY 430
Cdd:cd19483 155 SHLRRpgggkGHEE--GGEVSESDLRGSSAIAQLSDYVIGLERNKQADDPVERNTTRVRVLKNRFtgetGIAGTLY 228
|
|
| PRK05973 |
PRK05973 |
replicative DNA helicase; Provisional |
183-382 |
6.09e-10 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168322 [Multi-domain] Cd Length: 237 Bit Score: 59.28 E-value: 6.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 183 AHAAGLTLGIESLDRLMApkqalrGSLVVIGARPKMGKTAAFNKIAVHfALNHRLPTLVFSLEMTDRSLIERMVA--QEA 260
Cdd:PRK05973 46 AKAAATTPAEELFSQLKP------GDLVLLGARPGHGKTLLGLELAVE-AMKSGRTGVFFTLEYTEQDVRDRLRAlgADR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531976 261 KVNSEIFylgpndESELSLAIAkageiaeSNMMIDSTAGVTlahivaecrkvkrmRGSvgLVAIDYLTLMkteSAERRDI 340
Cdd:PRK05973 119 AQFADLF------EFDTSDAIC-------ADYIIARLASAP--------------RGT--LVVIDYLQLL---DQRREKP 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 446531976 341 AYGDITTGLKNLAKELDCVVVLLTQLNRKLEERA-------DKR-PNPSD 382
Cdd:PRK05973 167 DLSVQVRALKSFARERGLIIVFISQIDRSFDPSAkplpdirDVRlPNPLD 216
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
389-435 |
2.17e-03 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 40.50 E-value: 2.17e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 446531976 389 IEQDCDVWIGLYRDAVYN-ENADPNLMEMLLRLNREGPSGTAYALMKN 435
Cdd:PRK07773 828 IEQDADVVILLYRPDYYDrDDPRGGEAEFIVAKHRNGPTGTVTLAFQL 875
|
|
| |
