|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
234-898 |
0e+00 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 666.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 234 DSLPKRWHDYEERITETQEGFSKLIPWLKEGDTFRNELFETEAWNFLTEASNELLAAGITILLPSWWQNLKATKPKLRVQ 313
Cdd:COG0553 20 LLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 314 LKQNTVQTQSFFGMNTLVNFDWRISTNGIDLSESEFFELVEQNKRLFNINGQWMRLDPAF---IEEVRKLMNRADKYGLE 390
Cdd:COG0553 100 LAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLgrlLLLALLLLALEALLLLG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 391 MKDVLQQHLSNTAETEIVEDDSPFTDIEIELDGYYEELFQKLLHIGDIPKV--DVPASLNATLRPYQQHGIEWLLYLRKL 468
Cdd:COG0553 180 LLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREAleSLPAGLKATLRPYQLEGAAWLLFLRRL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 469 GFGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFERFAPNLRVQLHYGS-NRDKGnsfEDFLQ 547
Cdd:COG0553 260 GLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTrERAKG---ANPFE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 548 SADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGY 627
Cdd:COG0553 336 DADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGL 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 628 LGSLGQFQRRFVTPIEKDrDEGKIQQVQRFISPFLLRRTKKDqtVALNLPDKQEQKAYCPLTGEQASLYEQLVQDTLQNV 707
Cdd:COG0553 416 LGSLKAFRERFARPIEKG-DEEALERLRRLLRPFLLRRTKED--VLKDLPEKTEETLYVELTPEQRALYEAVLEYLRREL 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 708 EGLSGIERRGFILLMLNKLKQICNHPALYLKEEEPQNVveRSMKTKTLMELIENIKDQNESCLIFTQYIGMGNMLKRVLE 787
Cdd:COG0553 493 EGAEGIRRRGLILAALTRLRQICSHPALLLEEGAELSG--RSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLE 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 788 EKfGQRVLFLNGSVPKKDRDKMIEEFQNGTY-DIFILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATDRAYRIGQKR 866
Cdd:COG0553 571 ER-GIEYAYLHGGTSAEERDELVDRFQEGPEaPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTR 649
|
650 660 670
....*....|....*....|....*....|..
gi 446532772 867 FVHVHKLITTGTLEEKIDEMLERKQSLNNAVI 898
Cdd:COG0553 650 DVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
447-667 |
1.72e-115 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 351.87 E-value: 1.72e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 447 LNATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFERFAPNL 526
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRK-GPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 527 RVQLHYGSNRDKGNSFEdfLQSADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTG 606
Cdd:cd18012 80 KVLVIHGTKRKREKLRA--LEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTG 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532772 607 TPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRDEGKIQQVQRFISPFLLRRTK 667
Cdd:cd18012 158 TPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEALEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
444-898 |
2.09e-85 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 295.56 E-value: 2.09e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 444 PASLNATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFA 523
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFC 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 524 PNLRVQLHYGSNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHK 601
Cdd:PLN03142 243 PVLRAVKFHGNPEERAHQREELLVAGkfDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 602 IALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRDEgKIQQVQRFISPFLLRRTKKDqtVALNLPDKQE 681
Cdd:PLN03142 323 LLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQE-VVQQLHKVLRPFLLRRLKSD--VEKGLPPKKE 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 682 QKAYCPLTGEQASLYEQLVQDTLQNVEGlsGIERRGfILLMLNKLKQICNHPALYlKEEEP-------QNVVERSMKTKT 754
Cdd:PLN03142 400 TILKVGMSQMQKQYYKALLQKDLDVVNA--GGERKR-LLNIAMQLRKCCNHPYLF-QGAEPgppyttgEHLVENSGKMVL 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 755 LMELIENIKDQNESCLIFTQYIGMGNMLKRVLEEKfGQRVLFLNGSVPKKDRDKMIEEFQ--NGTYDIFILSLKAGGTGL 832
Cdd:PLN03142 476 LDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYR-GYQYCRIDGNTGGEDRDASIDAFNkpGSEKFVFLLSTRAGGLGI 554
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532772 833 NLTAANHVIHYDRWWNPAVENQATDRAYRIGQKRFVHVHKLITTGTLEEKIDEMLERKQSLNNAVI 898
Cdd:PLN03142 555 NLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVI 620
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
454-736 |
1.35e-74 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 246.44 E-value: 1.35e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 454 YQQHGIEWLLYL-RKLGFGALLADDMGLGKSIQTISYLLYIKE-NNLKTGPALIVAPTSVLGNWQKEFERFA--PNLRVQ 529
Cdd:pfam00176 1 YQIEGVNWMLSLeNNLGRGGILADEMGLGKTLQTISLLLYLKHvDKNWGGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 530 LHYGSNRDKGNSFED--FLQSADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGT 607
Cdd:pfam00176 81 VLHGNKRPQERWKNDpnFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 608 PMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRDEGKIQQVQRFISPFLLRRTKKDqtVALNLPDKQEQKAYCP 687
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSRLHKLLKPFLLRRTKKD--VEKSLPPKVEYILFCR 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446532772 688 LTGEQASLYEQLVQ----DTLQNVEGLSGIERRGFILLMLnkLKQICNHPALY 736
Cdd:pfam00176 239 LSKLQRKLYQTFLLkkdlNAIKTGEGGREIKASLLNILMR--LRKICNHPGLI 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
451-628 |
3.77e-70 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 230.15 E-value: 3.77e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRDKGNSFEDFLQ-SADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTPM 609
Cdd:cd17919 81 YHGSQRERAQIRAKEKLdKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPL 160
|
170
....*....|....*....
gi 446532772 610 ENRLAELWSIFDFINHGYL 628
Cdd:cd17919 161 QNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
451-665 |
1.81e-63 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 213.75 E-value: 1.81e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYL-----LYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPN 525
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILasdhhKRANSFNSENLPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 526 --LRVQLHYGSNRDKgNSFEDFLQSADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIA 603
Cdd:cd17999 81 afLKPLAYVGPPQER-RRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLI 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 604 LTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPI---------EKDRDEGK--IQQVQRFISPFLLRR 665
Cdd:cd17999 160 LSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPIlasrdskasAKEQEAGAlaLEALHKQVLPFLLRR 232
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
451-665 |
6.20e-55 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 190.28 E-value: 6.20e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLkTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGL-IKSVLVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRD-KGNSFEDFLQSADVVLTSYALAQLDEEELTS-----LCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIAL 604
Cdd:cd18001 80 FHGTSKKeRERNLERIQRGGGVLLTTYGMVLSNTEQLSAddhdeFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIIL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 605 TGTPMENRLAELWSIFDFI-NHGYLGSLGQFQRRFVTPIE---------KDRDEGKI--QQVQRFISPFLLRR 665
Cdd:cd18001 160 TGTPIQNNLKELWALFDFAcNGSLLGTRKTFKMEFENPITrgrdkdatqGEKALGSEvaENLRQIIKPYFLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
451-665 |
2.23e-54 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 189.13 E-value: 2.23e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYI---------KENNLKT-----------GPALIVAPTS 510
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVlgktgtrrdRENNRPRfkkkppassakKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 511 VLGNWQKEFERFApNLRVQLHYGSNRDKGnsFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTK 588
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGSRKDDE--LEGRLKAGrlEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 589 QSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEK---------DRDEGK--IQQVQRF 657
Cdd:cd18005 158 LTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRgqrhtatarELRLGRkrKQELAVK 237
|
....*...
gi 446532772 658 ISPFLLRR 665
Cdd:cd18005 238 LSKFFLRR 245
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
742-874 |
1.10e-53 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 182.68 E-value: 1.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 742 PQNVVERSMKTKTLMELIENIKDQNESCLIFTQYIGMGNMLKRVLEEKfGQRVLFLNGSVPKKDRDKMIEEFQNGT-YDI 820
Cdd:cd18793 3 PKIEEVVSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-GIKYLRLDGSTSSKERQKLVDRFNEDPdIRV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446532772 821 FILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATDRAYRIGQKRFVHVHKLI 874
Cdd:cd18793 82 FLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
451-665 |
2.21e-51 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 179.86 E-value: 2.21e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRD---------KGNSFEdflqsadVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHK 601
Cdd:cd18003 81 YYGSAKErklkrqgwmKPNSFH-------VCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRR 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 602 IALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIE------KDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd18003 154 LLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTamsegsQEENEELVRRLHKVLRPFLLRR 223
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
451-665 |
4.08e-51 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 179.79 E-value: 4.08e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWL---LYLRKL--GFGALLADDMGLGKSIQTISyLLYIKennLKTGP--------ALIVAPTSVLGNWQK 517
Cdd:cd18004 1 LRPHQREGVQFLydcLTGRRGygGGGAILADEMGLGKTLQAIA-LVWTL---LKQGPygkptakkALIVCPSSLVGNWKA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 518 EFERFAPNLRVQ-LHYGSNRDKGNSFEDFLQSA---DVVLTSYALAQLDEEELTSL-CWDAVILDEAQNIKNPHTKQSKA 592
Cdd:cd18004 77 EFDKWLGLRRIKvVTADGNAKDVKASLDFFSSAstyPVLIISYETLRRHAEKLSKKiSIDLLICDEGHRLKNSESKTTKA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 593 VRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRD-----------EGKIQQVQRFISPF 661
Cdd:cd18004 157 LNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDpdaseedkelgAERSQELSELTSRF 236
|
....
gi 446532772 662 LLRR 665
Cdd:cd18004 237 ILRR 240
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
451-628 |
2.22e-50 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 175.98 E-value: 2.22e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQ- 529
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 530 LH----YGSNRDKGNSFEDFLQSAD-------VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQA 598
Cdd:cd18000 81 LHssgsGTGSEEKLGSIERKSQLIRkvvgdggILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160
|
170 180 190
....*....|....*....|....*....|
gi 446532772 599 NHKIALTGTPMENRLAELWSIFDFINHGYL 628
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
448-667 |
4.96e-50 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 176.42 E-value: 4.96e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 448 NATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFERFAPNLR 527
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVW-GPFLVIAPLSTLPNWVNEFARFTPSVP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGSN------RDKGNSFEDFLQSADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHK 601
Cdd:cd18009 80 VLLYHGTKeererlRKKIMKREGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446532772 602 IALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRF-----------VTPIEKDRDEGKIQQVQRFISPFLLRRTK 667
Cdd:cd18009 160 LLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfsslsdnaadISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
448-667 |
3.75e-49 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 173.28 E-value: 3.75e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 448 NATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLR 527
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGSNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALT 605
Cdd:cd17997 81 VVVLIGDKEERADIIRDVLLPGkfDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532772 606 GTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRDEGKIQQVQRFISPFLLRRTK 667
Cdd:cd17997 161 GTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
451-665 |
5.47e-49 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 173.63 E-value: 5.47e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYlrklgFGALLADDMGLGKSIQTIS---------------YLLYIKENNLKTGPA--LIVAPTSVLG 513
Cdd:cd18008 1 LLPYQKQGLAWMLP-----RGGILADEMGLGKTIQALAlilatrpqdpkipeeLEENSSDPKKLYLSKttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 514 NWQKEFERF--APNLRVQLHYGSNRdkgNSFEDFLQSADVVLTSY-------------ALAQLDEEELTSLC---WDAVI 575
Cdd:cd18008 76 QWKDEIEKHtkPGSLKVYVYHGSKR---IKSIEELSDYDIVITTYgtlasefpknkkgGGRDSKEKEASPLHrirWYRVI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 576 LDEAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGqFQRRFVTPIEKDRDEGKIQQVQ 655
Cdd:cd18008 153 LDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYP-WFNSDISKPFSKNDRKALERLQ 231
|
250
....*....|
gi 446532772 656 RFISPFLLRR 665
Cdd:cd18008 232 ALLKPILLRR 241
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
451-623 |
6.28e-43 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 154.47 E-value: 6.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNlKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIG-IPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRDKGNSFEDFLQSA---DVVLTSYALAQLDEEE---LTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIAL 604
Cdd:cd17998 80 YYGSQEERKHLRYDILKGLedfDVIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLL 159
|
170
....*....|....*....
gi 446532772 605 TGTPMENRLAELWSIFDFI 623
Cdd:cd17998 160 TGTPLQNNLLELMSLLNFI 178
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
451-665 |
3.76e-42 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 153.36 E-value: 3.76e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRDKGN------SFEDFlqsaDVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIAL 604
Cdd:cd18006 81 YMGDKEKRLDlqqdikSTNRF----HVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 605 TGTPMENRLAELWSIFDFINHGYLG--SLGQFQRRFVtpiEKDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFPkdKLDDFIKAYS---ETDDESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
448-667 |
5.98e-42 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 153.29 E-value: 5.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 448 NATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLR 527
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGSNRDKGNSFEDFLQSA-DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAV-RNLQANHKIALT 605
Cdd:cd17996 81 KIVYKGTPDVRKKLQSQIRAGKfNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLnTYYHARYRLLLT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 606 GTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRDEGK-----------IQQVQRFISPFLLRRTK 667
Cdd:cd17996 161 GTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKielneeetlliIRRLHKVLRPFLLRRLK 233
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
451-665 |
1.35e-41 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 152.27 E-value: 1.35e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRD----------KGNSFEDflQSADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANH 600
Cdd:cd18002 81 YWGNPKDrkvlrkfwdrKNLYTRD--APFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532772 601 KIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDR------DEGKIQQVQRFISPFLLRR 665
Cdd:cd18002 159 RLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAenktglNEHQLKRLHMILKPFMLRR 229
|
|
| DUF3670 |
pfam12419 |
SNF2 Helicase protein; This domain family is found in bacteria, archaea and eukaryotes, and is ... |
270-399 |
1.84e-41 |
|
SNF2 Helicase protein; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00271, pfam00176. Most of the proteins in this family are annotated as SNF2 helicases but there is little accompanying literature to confirm this.
Pssm-ID: 463572 Cd Length: 136 Bit Score: 148.45 E-value: 1.84e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 270 ELFETEAWNFLTEASNELLAAGITILLPSWWQNLKATKPKLRVQLKQNTVQTQSFFGMNTLVNFDWRISTNGIDLSESEF 349
Cdd:pfam12419 7 ALTTEEAYEFLKEAAPRLEAAGFGVLLPAWWTKRRRPRLGLKLSAKGPAAAGGSFLGLDALLDFDWELALGDEELTEEEF 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446532772 350 FELVEQNKRLFNINGQWMRLDPAFIEEVRKLMNRADKYGLEMKDVLQQHL 399
Cdd:pfam12419 87 ERLAEAKRPLVRLRGQWVELDPEDLRAALEFLERRGKGGLTLADALRLAL 136
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
451-665 |
3.90e-41 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 150.48 E-value: 3.90e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFApNLRVQL 530
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGS--NRDKGNSFEDFLQSA-----------DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQ 597
Cdd:cd17995 80 YHGSgeSRQIIQQYEMYFKDAqgrkkkgvykfDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446532772 598 ANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF----GDLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
450-665 |
3.03e-39 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 145.19 E-value: 3.03e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 450 TLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQ 529
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 530 LHYG--SNRDKGNSFEDFLQSA-----DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKI 602
Cdd:cd17993 81 VYLGdiKSRDTIREYEFYFSQTkklkfNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 603 ALTGTPMENRLAELWSIFDFINHGYLGSLGQFQrrfvTPIEKDRDEGkIQQVQRFISPFLLRR 665
Cdd:cd17993 161 LITGTPLQNSLKELWALLHFLMPGKFDIWEEFE----EEHDEEQEKG-IADLHKELEPFILRR 218
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
448-665 |
6.02e-39 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 144.76 E-value: 6.02e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 448 NATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLR 527
Cdd:cd18054 18 NLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEIN 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGS--NRDKGNSFEDFLQSA-----DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANH 600
Cdd:cd18054 98 VVVYIGDlmSRNTIREYEWIHSQTkrlkfNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNH 177
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446532772 601 KIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGkIQQVQRFISPFLLRR 665
Cdd:cd18054 178 RLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDH----GKGRENG-YQSLHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
451-680 |
2.10e-38 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 143.65 E-value: 2.10e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTP 608
Cdd:cd18064 96 LIGDKDQRAAFVRDVLLPGewDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532772 609 MENRLAELWSIFDFINHGYLGSLGQFQRRFVTPiEKDRDEGKIQQVQRFISPFLLRRTKKDqtVALNLPDKQ 680
Cdd:cd18064 176 LQNNLHELWALLNFLLPDVFNSAEDFDSWFDTN-NCLGDQKLVERLHMVLRPFLLRRIKAD--VEKSLPPKK 244
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
451-665 |
6.05e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 137.57 E-value: 6.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYL--LYiKENNLKtGPALIVAPTSVLGNWQKEFERFAPNLRV 528
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLysLY-KEGHSK-GPFLVSAPLSTIINWEREFEMWAPDFYV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 529 QLHYGSNrdkgnsfedflqsadVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTP 608
Cdd:cd17994 79 VTYVGDH---------------VLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446532772 609 MENRLAELWSIFDFINHGYLGSLGQFQRRFvTPIEKdrdEGKIQQVQRFISPFLLRR 665
Cdd:cd17994 144 LQNNLEELFHLLNFLTPERFNNLQGFLEEF-ADISK---EDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
449-667 |
1.18e-36 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 138.23 E-value: 1.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 449 ATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRV 528
Cdd:cd18065 14 GTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 529 QLHYGSNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTG 606
Cdd:cd18065 94 VCLIGDKDARAAFIRDVMMPGewDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532772 607 TPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPiEKDRDEGKIQQVQRFISPFLLRRTK 667
Cdd:cd18065 174 TPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTK-NCLGDQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
451-665 |
4.12e-36 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 136.51 E-value: 4.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWL----LYLRKLG-FGALLADDMGLGKSIQTISYLLYIkennLKTGP---------ALIVAPTSVLGNWQ 516
Cdd:cd18066 1 LRPHQREGIEFLyecvMGMRVNErFGAILADEMGLGKTLQCISLIWTL----LRQGPyggkpvikrALIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 517 KEFERFAPNLRVQLHygsNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVR 594
Cdd:cd18066 77 KEFQKWLGSERIKVF---TVDQDHKVEEFIASPlySVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 595 NLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPI-----------EKDRDEGKIQQVQRFISPFLL 663
Cdd:cd18066 154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIvrsreptatpeEKKLGEARAAELTRLTGLFIL 233
|
..
gi 446532772 664 RR 665
Cdd:cd18066 234 RR 235
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
447-667 |
4.72e-36 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 137.12 E-value: 4.72e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 447 LNATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNL 526
Cdd:cd18063 20 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 527 rVQLHYGSNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVR-NLQANHKIA 603
Cdd:cd18063 100 -VKISYKGTPAMRRSLVPQLRSGkfNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNtHYVAPRRIL 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 604 LTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEK-----DRDEGK----IQQVQRFISPFLLRRTK 667
Cdd:cd18063 179 LTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMtgervDLNEEEtiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
451-643 |
9.61e-36 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 135.88 E-value: 9.61e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWL-------LYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFA 523
Cdd:cd18007 1 LKPHQVEGVRFLwsnlvgtDVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 524 PNLRVQLH--YGSNRDKgnsfeDFLQSADVV-------------------LTSYALAQLDEEELTSLCW-----DAVILD 577
Cdd:cd18007 81 PPDLRPLLvlVSLSASK-----RADARLRKInkwhkeggvlligyelfrnLASNATTDPRLKQEFIAALldpgpDLLVLD 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532772 578 EAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIE 643
Cdd:cd18007 156 EGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIE 221
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
440-667 |
1.04e-35 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 135.94 E-value: 1.04e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 440 KVDVPASL--NATLRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQK 517
Cdd:cd18062 11 KVEKQSSLlvNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 518 EFERFAPNLrVQLHYGSNRDKGNSFEDFLQSA--DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVR- 594
Cdd:cd18062 91 EFDKWAPSV-VKVSYKGSPAARRAFVPQLRSGkfNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNt 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 595 NLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPI----EK-DRDEGK----IQQVQRFISPFLLRR 665
Cdd:cd18062 170 HYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFamtgEKvDLNEEEtiliIRRLHKVLRPFLLRR 249
|
..
gi 446532772 666 TK 667
Cdd:cd18062 250 LK 251
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
468-665 |
1.02e-34 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 132.59 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 468 LGFGALLADDMGLGKSIQTISYLLyikennlkTGPALIVAPTSVLGNWQKEFERFAPN--LRVQLHYGSNRDKGNSFedf 545
Cdd:cd18071 47 LVRGGILADDMGLGKTLTTISLIL--------ANFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGERNRDPKL--- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 546 LQSADVVLTSYALAQLDE-----EELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIF 620
Cdd:cd18071 116 LSKYDIVLTTYNTLASDFgakgdSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLL 195
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446532772 621 DFINHGYLGSLGQFQRRFVTPIEKDrDEGKIQQVQRFISPFLLRR 665
Cdd:cd18071 196 SFLHLKPFSNPEYWRRLIQRPLTMG-DPTGLKRLQVLMKQITLRR 239
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
451-637 |
1.18e-33 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 128.86 E-value: 1.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLylRKLGfGALLADDMGLGKSIQTISYLLYIKENnlktGPALIVAPTSVLGNWQKEFERFAPNL---R 527
Cdd:cd18010 1 LLPFQREGVCFAL--RRGG-RVLIADEMGLGKTVQAIAIAAYYREE----WPLLIVCPSSLRLTWADEIERWLPSLppdD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGSNRDKGNSfedflqSADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNL--QANHKIALT 605
Cdd:cd18010 74 IQVIVKSKDGLRDG------DAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLS 147
|
170 180 190
....*....|....*....|....*....|..
gi 446532772 606 GTPMENRLAELWSIFDFINHGYLGSLGQFQRR 637
Cdd:cd18010 148 GTPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
451-665 |
1.89e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 125.95 E-value: 1.89e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSN------RDKGNSFED---------FLQSAD------VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQ 589
Cdd:cd18057 81 YTGDKesrsviRENEFSFEDnairsgkkvFRMKKEaqikfhVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532772 590 SKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDrdegKIQQVQRFISPFLLRR 665
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKED----QIKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
451-665 |
7.99e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 124.41 E-value: 7.99e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSN------RDKGNSFED-----------FLQSAD----VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQ 589
Cdd:cd18056 81 YVGDKdsraiiRENEFSFEDnairggkkasrMKKEASvkfhVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532772 590 SKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDrdegKIQQVQRFISPFLLRR 665
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKED----QIKKLHDMLGPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
451-665 |
9.86e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 123.97 E-value: 9.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGSN------RDKGNSFED---------FLQSAD------VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQ 589
Cdd:cd18055 81 YTGDKdsraiiRENEFSFDDnavkggkkaFKMKREaqvkfhVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532772 590 SKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDrdegKIQQVQRFISPFLLRR 665
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKED----QIKKLHDLLGPHMLRR 232
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
451-624 |
1.16e-31 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 124.13 E-value: 1.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYL-RKLGFGALLADDMGLGKSIQTISYLLYIKENN----------------------LKTGPALIVA 507
Cdd:cd18072 1 LLLHQKQALAWLLWReRQKPRGGILADDMGLGKTLTMIALILAQKNTQnrkeeekekalteweskkdstlVPSAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 508 PTSVLGNWQKEFER--FAPNLRVQLHYGSNRDKGNSFedfLQSADVVLTSYALA----QLDEEELTS-----LCWDAVIL 576
Cdd:cd18072 81 PASLVHQWKNEVESrvASNKLRVCLYHGPNRERIGEV---LRDYDIVITTYSLVakeiPTYKEESRSsplfrIAWARIIL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 446532772 577 DEAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFIN 624
Cdd:cd18072 158 DEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
451-665 |
1.49e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 120.16 E-value: 1.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFERFApNLRVQL 530
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIH-GPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGS--NRDKGNSFEDFLQSA-----------DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQ 597
Cdd:cd18060 79 YHGSlaSRQMIQQYEMYCKDSrgrlipgaykfDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446532772 598 ANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF----GDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
451-665 |
3.88e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 119.38 E-value: 3.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTGPALIVAPTSVLGNWQKEFERFAPNLRVQL 530
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYG--SNRDKGNSFEDFLQSA-----DVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIA 603
Cdd:cd18053 101 YLGdiNSRNMIRTHEWMHPQTkrlkfNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532772 604 LTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGkIQQVQRFISPFLLRR 665
Cdd:cd18053 181 ITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEH----GKGREYG-YASLHKELEPFLLRR 237
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
451-643 |
5.50e-30 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 118.76 E-value: 5.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLL---------YLRKLGFGALLADDMGLGKSIQTISYL-LYIKENNLKTgpALIVAPTSVLGNWQKEFE 520
Cdd:cd18069 1 LKPHQIGGIRFLYdniieslerYKGSSGFGCILAHSMGLGKTLQVISFLdVLLRHTGAKT--VLAIVPVNTLQNWLSEFN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 521 RFAP-----------NLRVQL---HYGSNRDKGNSFEDFLQSADVVLTSYALAQLDEEEltslcwDAVILDEAQNIKNPH 586
Cdd:cd18069 79 KWLPppealpnvrprPFKVFIlndEHKTTAARAKVIEDWVKDGGVLLMGYEMFRLRPGP------DVVICDEGHRIKNCH 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446532772 587 TKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIE 643
Cdd:cd18069 153 ASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPIL 209
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
451-665 |
9.86e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 117.83 E-value: 9.86e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFeRFAPNLRVQL 530
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIH-GPFLVIAPLSTIPNWEREF-RTWTELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGS--NRDKGNSFEDFLQSAD-----------VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQ 597
Cdd:cd18059 79 YHGSqaSRRTIQLYEMYFKDPQgrvikgsykfhAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMD 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446532772 598 ANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd18059 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF----GDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
451-665 |
1.15e-29 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 117.84 E-value: 1.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLL---YLRKlgfGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFeRFAPNLR 527
Cdd:cd18058 1 LREYQLEGMNWLLfnwYNRK---NCILADEMGLGKTIQSITFLSEIFLMGIR-GPFLIIAPLSTITNWEREF-RTWTEMN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGS--NRDKGNSFEDFLQSAD-----------VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVR 594
Cdd:cd18058 76 AIVYHGSqiSRQMIQQYEMYYRDEQgnplsgifkfqVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLK 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532772 595 NLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd18058 156 LMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF----GDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
451-664 |
4.62e-29 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 117.06 E-value: 4.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLrklgfGALLADDMGLGKSIQTISYLL-------------------------YIKENNLKTGPALI 505
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALILlhprpdndldaadddsdemvccpdcLVAETPVSSKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 506 VAPTSVLGNWQKEFERFAPN-LRVQLHYGSNRDKG--NSFEDFLQSADVVLTSY-ALA-QLDEEE--------------- 565
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQGVKKDGAlaSPAPEILAEYDIVVTTYdVLRtELHYAEanrsnrrrrrqkrye 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 566 -----LTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHgYLGSLGQFQRRFVt 640
Cdd:cd18070 156 appspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV-EPFCDSDWWARVL- 233
|
250 260
....*....|....*....|....
gi 446532772 641 pIEKDRDEGKIQQVQRFISPFLLR 664
Cdd:cd18070 234 -IRPQGRNKAREPLAALLKELLWR 256
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
451-665 |
4.29e-28 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 113.18 E-value: 4.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKtGPALIVAPTSVLGNWQKEFeRFAPNLRVQL 530
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIR-GPFLIIAPLSTIANWEREF-RTWTDLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 531 HYGS--NRDKGNSFEDFLQSAD-----------VVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNLQ 597
Cdd:cd18061 79 YHGSliSRQMIQQYEMYFRDSQgriirgayrfqAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMN 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446532772 598 ANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFvtpiEKDRDEGKIQQVQRFISPFLLRR 665
Cdd:cd18061 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF----GDLKTEEQVQKLQAILKPMMLRR 222
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
751-863 |
4.01e-27 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 106.14 E-value: 4.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 751 KTKTLMELIEniKDQNESCLIFTQYIgmgNMLK-RVLEEKFGQRVLFLNGSVPKKDRDKMIEEFQNGTYDIfILSLKAGG 829
Cdd:pfam00271 2 KLEALLELLK--KERGGKVLIFSQTK---KTLEaELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDV-LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 446532772 830 TGLNLTAANHVIHYDRWWNPAVENQATDRAYRIG 863
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
451-665 |
1.02e-26 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 109.87 E-value: 1.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLL-----YLRKLGFGALLADDMGLGKSIQTISYLLYIkennLKTGP--------ALIVAPTSVLGNWQK 517
Cdd:cd18067 1 LRPHQREGVKFLYrcvtgRRIRGSHGCIMADEMGLGKTLQCITLMWTL----LRQSPqckpeidkAIVVSPSSLVKNWAN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 518 EFERF-APNLR-VQLHYGSNRDKGNSFEDFLQ------SADVVLTSYALAQLDEEELTSLCWDAVILDEAQNIKNPHTKQ 589
Cdd:cd18067 77 ELGKWlGGRLQpLAIDGGSKKEIDRKLVQWASqqgrrvSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 590 SKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDRD-----------EGKIQQVQRFI 658
Cdd:cd18067 157 YQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDadasekerqlgEEKLQELISIV 236
|
....*..
gi 446532772 659 SPFLLRR 665
Cdd:cd18067 237 NRCIIRR 243
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
443-636 |
6.46e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 100.26 E-value: 6.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 443 VPASLNATLRPYQQHGIEWLLYLRKlgfGALLADDMGLGKSIQ-TISYLLYIKENnlKTGPALIVAPTSVL-GNWQKEFE 520
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAaLLPALEALKRG--KGGRVLVLVPTRELaEQWAEELK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 521 RFAPNLRVQLHYGSNRDKGNSFEDFLQS--ADVVLTSY--ALAQLDEEELTSLCWDAVILDEAQNIKNP-HTKQSKAVRN 595
Cdd:smart00487 76 KLGPSLGLKVVGLYGGDSKREQLRKLESgkTDILVTTPgrLLDLLENDKLSLSNVDLVILDEAHRLLDGgFGDQLEKLLK 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 446532772 596 L--QANHKIALTGTP---MENRLAELWSIFDFINHGYLGSLGQFQR 636
Cdd:smart00487 156 LlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
451-646 |
2.40e-22 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 97.27 E-value: 2.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWL---------LYLRKLGFGALLADDMGLGKSIQTISY----LLYIKENNLKTgpALIVAPTSVLGNWQK 517
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFlhtvLLCEKLENFSR--VLVVCPLNTVLNWLN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 518 EFERFAPNLRVQ--------LHYGSNRDKGNSFEDFLQSADVVLTSYA----LAQLDE------------EELTSLCWDA 573
Cdd:cd18068 79 EFEKWQEGLKDEekievnelATYKRPQERSYKLQRWQEEGGVMIIGYDmyriLAQERNvksreklkeifnKALVDPGPDF 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532772 574 VILDEAQNIKNPHTKQSKAVRNLQANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQRRFVTPIEKDR 646
Cdd:cd18068 159 VVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQ 231
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
451-636 |
8.91e-22 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 94.28 E-value: 8.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIewLLYLRKLGFGALLADDMGLGKsiqTISYLLYIKENNLKT--GPALIVAPTSVLGNWQKE-FERFapNLR 527
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGK---TIEAGLIIKELLLRGdaKRVLILCPASLVEQWQDElQDKF--GLP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGSN-----RDKGNSFEDFlqsaDVVLTSYALAQLDEEELTSL---CWDAVILDEAQNIKN----PHTKQSKAVRN 595
Cdd:cd18011 74 FLILDRETaaqlrRLIGNPFEEF----PIVIVSLDLLKRSEERRGLLlseEWDLVVVDEAHKLRNsgggKETKRYKLGRL 149
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 446532772 596 L--QANHKIALTGTPMENRLAELWSIFDFINHGYLGSLGQFQR 636
Cdd:cd18011 150 LakRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLR 192
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
782-863 |
7.21e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 87.65 E-value: 7.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 782 LKRVLEEKfGQRVLFLNGSVPKKDRDKMIEEFQNGTYDIfILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATDRAYR 861
Cdd:smart00490 3 LAELLKEL-GIKVARLHGGLSQEEREEILDKFNNGKIKV-LVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 446532772 862 IG 863
Cdd:smart00490 81 AG 82
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
451-642 |
1.81e-19 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 88.18 E-value: 1.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIEWLLYLRKlgfGALLADdMGLGKSIQTISYLLYIKENNlKTGPALIVAPTSVLGN-WQKEFERFA--PNLR 527
Cdd:cd18013 1 PHPYQKVAINFIIEHPY---CGLFLD-MGLGKTVTTLTALSDLQLDD-FTRRVLVIAPLRVARStWPDEVEKWNhlRNLT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 VQLHYGSNRDKGNSFEdflQSADVVLTSYA-LAQLDEEELTSLCWDAVILDEAQNIKNPHTKQSKAVRNL--QANHKIAL 604
Cdd:cd18013 76 VSVAVGTERQRSKAAN---TPADLYVINREnLKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVrpVIKRLIGL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446532772 605 TGTPMENRLAELWSIFDFINHG-YLG-SLGQFQRRFVTPI 642
Cdd:cd18013 153 TGTPSPNGLMDLWAQIALLDQGeRLGrSITAYRERWFDPD 192
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
403-841 |
1.83e-18 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 90.08 E-value: 1.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 403 AETEIVEDDSPFTDIEIELDGYYEELFQKLLHIGDIPKVDVPASLNATLRPYQQHGIE-WLLYLRKLGFGALLADDMGLG 481
Cdd:COG1061 33 NLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFELRPYQQEALEaLLAALERGGGRGLVVAPTGTG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 482 KSI---QTISYLLYIKennlktgPALIVAPTSVLGN-WQKEFERFapnLRVQLHYGSNRDKGnsfedflqsADVVLTSYA 557
Cdd:COG1061 113 KTVlalALAAELLRGK-------RVLVLVPRRELLEqWAEELRRF---LGDPLAGGGKKDSD---------APITVATYQ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 558 -LAQLDEEELTSLCWDAVILDEAQNIknPHTKQSKAVRNLQANHKIALTGTP-MENRLAELWSIFDFINHGYlgSLGQFQ 635
Cdd:COG1061 174 sLARRAHLDELGDRFGLVIIDEAHHA--GAPSYRRILEAFPAAYRLGLTATPfRSDGREILLFLFDGIVYEY--SLKEAI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 636 RrfvtpiekdrdegkiqqvQRFISPFLLRRTKKDQTvalnlpdkQEQKAYCPLTgeqASLYEQLVQDTlqnveglsgier 715
Cdd:COG1061 250 E------------------DGYLAPPEYYGIRVDLT--------DERAEYDALS---ERLREALAADA------------ 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 716 rgfillmlnklkqicnhpalylkeeepqnvverSMKTKTLMELIENIKDqNESCLIFTQYIGMGNMLKRVLEEKfGQRVL 795
Cdd:COG1061 289 ---------------------------------ERKDKILRELLREHPD-DRKTLVFCSSVDHAEALAELLNEA-GIRAA 333
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 446532772 796 FLNGSVPKKDRDKMIEEFQNGTYDIfILSLKAGGTGLNLTAANHVI 841
Cdd:COG1061 334 VVTGDTPKKEREEILEAFRDGELRI-LVTVDVLNEGVDVPRLDVAI 378
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
451-608 |
7.72e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.39 E-value: 7.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 451 LRPYQQHGIE-WLLYLRKLGfgALLADDMGLGKSIQTISYLLYIKENNLktgpaLIVAPTSVLGN-WQKEFERFAPNLRV 528
Cdd:cd17926 1 LRPYQEEALEaWLAHKNNRR--GILVLPTGSGKTLTALALIAYLKELRT-----LIVVPTDALLDqWKERFEDFLGDSSI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 529 qlhygsNRDKGNSFEDFLqSADVVLTSYALAQLDEEELTSLC--WDAVILDEAQNIknPHTKQSKAVRNLQANHKIALTG 606
Cdd:cd17926 74 ------GLIGGGKKKDFD-DANVVVATYQSLSNLAEEEKDLFdqFGLLIVDEAHHL--PAKTFSEILKELNAKYRLGLTA 144
|
..
gi 446532772 607 TP 608
Cdd:cd17926 145 TP 146
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
466-614 |
1.15e-08 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 55.50 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 466 RKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTgpaLIVAPTSVL-GNWQKEFERFAPNLRVQLHYGSNRdkgnsfED 544
Cdd:cd17918 33 SPEPMDRLLSGDVGSGKTLVALGAALLAYKNGKQV---AILVPTEILaHQHYEEARKFLPFINVELVTGGTK------AQ 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 545 FLQSADVVLTSYALAQLDEEELTSlcwDAVILDEAQNIKnphTKQSKAVRNLQANHKIALTGTPMENRLA 614
Cdd:cd17918 104 ILSGISLLVGTHALLHLDVKFKNL---DLVIVDEQHRFG---VAQREALYNLGATHFLEATATPIPRTLA 167
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
745-844 |
2.78e-08 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 53.28 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 745 VVERSMKTKTLMELIENiKDQNESCLIFTQYIGMGNMLKRVLEEkFGQRVLFLNGSVPKKDRDKMIEEFQNGTYDIFIls 824
Cdd:cd18787 7 VVEEEEKKLLLLLLLLE-KLKPGKAIIFVNTKKRVDRLAELLEE-LGIKVAALHGDLSQEERERALKKFRSGKVRVLV-- 82
|
90 100
....*....|....*....|....*
gi 446532772 825 lkAggT-----GLNLTAANHVIHYD 844
Cdd:cd18787 83 --A--TdvaarGLDIPGVDHVINYD 103
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
450-608 |
4.11e-07 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 50.75 E-value: 4.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 450 TLRPYQQHGIE-WLLYLRKLGFGALLADDMGLGKSIQTISYLLYIKENNLKTgPALIVAPT-SVLGNWQKEFERFAPNLR 527
Cdd:pfam04851 3 ELRPYQIEAIEnLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIK-KVLFLVPRkDLLEQALEEFKKFLPNYV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 528 vqLHYGSNrdKGNSFEDFLQSADVVLTSY----ALAQLDEEELTSLCWDAVILDEAqniknpHTKQSKAVRN----LQAN 599
Cdd:pfam04851 82 --EIGEII--SGDKKDESVDDNKIVVTTIqslyKALELASLELLPDFFDVIIIDEA------HRSGASSYRNileyFKPA 151
|
....*....
gi 446532772 600 HKIALTGTP 608
Cdd:pfam04851 152 FLLGLTATP 160
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
745-844 |
9.30e-07 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 52.46 E-value: 9.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 745 VVERSMKTKTLMELIENikDQNESCLIFTQYIGMGNMLKRVLEEKfGQRVLFLNGSVPKKDRDKMIEEFQNGTYDIFIls 824
Cdd:COG0513 222 LVDKRDKLELLRRLLRD--EDPERAIVFCNTKRGADRLAEKLQKR-GISAAALHGDLSQGQRERALDAFRNGKIRVLV-- 296
|
90 100
....*....|....*....|....*
gi 446532772 825 lkagGT-----GLNLTAANHVIHYD 844
Cdd:COG0513 297 ----ATdvaarGIDIDDVSHVINYD 317
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
751-897 |
3.08e-06 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 50.88 E-value: 3.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 751 KTKTLMELIENI--KDQNESCLIFTQYIGMGNMLKRVLEE------KF-GQRVLFLNGSVPKKDRDKMIEEFQNGTYDIF 821
Cdd:COG1111 336 KLSKLREILKEQlgTNPDSRIIVFTQYRDTAEMIVEFLSEpgikagRFvGQASKEGDKGLTQKEQIEILERFRAGEFNVL 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 822 IlSLKAGGTGLNLTAANHVIHYDRWWNPAVENQatdRAYRIGQKRFVHVHKLITTGTLEE--------KIDEMLERKQSL 893
Cdd:COG1111 416 V-ATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQ---RKGRTGRKREGRVVVLIAKGTRDEayywssrrKEKKMKSILKKL 491
|
....
gi 446532772 894 NNAV 897
Cdd:COG1111 492 KKLL 495
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
794-865 |
3.58e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 45.77 E-value: 3.58e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532772 794 VLFLNgsvPKKDRDKMIEEFQngtydiFILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATDRAYRIGQK 865
Cdd:cd18785 7 IVFTN---SIEHAEEIASSLE------ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
751-841 |
1.46e-05 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 46.09 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 751 KTKTLMELIENIKdQNESCLIFTQYIGMGNMLKRVLeekfgqRVLFLNGSVPKKDRDKMIEEFQNGTYDIFILSlKAGGT 830
Cdd:cd18789 35 KLRALEELLKRHE-QGDKIIVFTDNVEALYRYAKRL------LKPFITGETPQSEREEILQNFREGEYNTLVVS-KVGDE 106
|
90
....*....|.
gi 446532772 831 GLNLTAANHVI 841
Cdd:cd18789 107 GIDLPEANVAI 117
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
744-864 |
2.20e-04 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 44.76 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 744 NVVERSMKTKTLMELIENIKDQNESCLIFTQYIGMGNMLKRVLEEKfGQRVLFLNGSVPKKDRDKMIEEFQNGTYDIFIL 823
Cdd:PTZ00110 355 FVVEEHEKRGKLKMLLQRIMRDGDKILIFVETKKGADFLTKELRLD-GWPALCIHGDKKQEERTWVLNEFKTGKSPIMIA 433
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446532772 824 SLKAgGTGLNLTAANHVIHYDrwwnpaVENQATDRAYRIGQ 864
Cdd:PTZ00110 434 TDVA-SRGLDVKDVKYVINFD------FPNQIEDYVHRIGR 467
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
722-864 |
5.60e-04 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 43.36 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 722 MLNKLKQICNHPALYlkEEEPQNVVERSMKTKTLM-------ELIENIKDQN--ESCLIFTQyigMGNMLKRVLEE--KF 790
Cdd:PRK01297 284 VMNLAKQWTTDPAIV--EIEPENVASDTVEQHVYAvagsdkyKLLYNLVTQNpwERVMVFAN---RKDEVRRIEERlvKD 358
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532772 791 GQRVLFLNGSVPKKDRDKMIEEFQNGTYDIFILSLKAgGTGLNLTAANHVIHYdrwwnpAVENQATDRAYRIGQ 864
Cdd:PRK01297 359 GINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVA-GRGIHIDGISHVINF------TLPEDPDDYVHRIGR 425
|
|
| uvsW |
PHA02558 |
UvsW helicase; Provisional |
739-841 |
2.42e-03 |
|
UvsW helicase; Provisional
Pssm-ID: 222875 [Multi-domain] Cd Length: 501 Bit Score: 41.53 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532772 739 EEEPQNVVERSMKTKTLMELIENIKDQNESCLIFTQYIGMGNMLKRVLEeKFGQRVLFLNGSVPKKDRDKMIEEFQNGTY 818
Cdd:PHA02558 317 QEEIKYITSHTKRNKWIANLALKLAKKGENTFVMFKYVEHGKPLYEMLK-KVYDKVYYVSGEVDTEDRNEMKKIAEGGKG 395
|
90 100
....*....|....*....|...
gi 446532772 819 DIFILSLKAGGTGLNLTAANHVI 841
Cdd:PHA02558 396 IIIVASYGVFSTGISIKNLHHVI 418
|
|
| |
