|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-458 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 595.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 2 INRTLKQVEQMINGTGLAEqyEGITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVanpPENL 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGD--PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL---PADL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 82 PVIFVEDTLLALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENTEVA 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 162 VLEMGMSSRGEIEFLSKLARPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEmnLAT 241
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAER--AKA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 242 ETVTFGDARANDYYPTTVTLQATGTHFKMN-REENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGM 320
Cdd:COG0770 234 RVLTFGLSEDADVRAEDIELDEDGTRFTLHtPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 321 RMEIVKKDSGLTVINDAYNASPTAMEAAFHLMNGLDGFSQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYGRL 400
Cdd:COG0770 314 RLEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGEL 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 446533323 401 GAQIAEGaeinFPGERVKAYHNKEELVKDLQAVVGNNDVVLVKASRGMKLEEVITMLK 458
Cdd:COG0770 394 ARAIAEA----AGGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALK 447
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
32-457 |
1.13e-154 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 445.17 E-value: 1.13e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 32 IDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVaNPPENLPVIFVEDTLLALQMLAKNYRDQLDVKVIGV 111
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREV-GPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 112 TGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENTEVAVLEMGMSSRGEIEFLSKLARPNAAIITNIG 191
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 192 EAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEmNLATETVTFGDARAnDYYPTTVTLQATG-THFKM 270
Cdd:TIGR01143 160 PAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKR-LPNRNILSFGFEGG-DFVAKDISYSALGsTSFTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 271 NREENISFY-IPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGMRMEIVKKDsGLTVINDAYNASPTAMEAAF 349
Cdd:TIGR01143 238 VAPGGEFEVsLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKN-GLTLIDDTYNANPDSMRAAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 350 HLMNGLDGfsQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYGRLGAQIAEgaeinFPGERVKAYHNKEELVKD 429
Cdd:TIGR01143 317 DALARFPG--KKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYD-----SFGKQGKHFADKDELLAF 389
|
410 420
....*....|....*....|....*...
gi 446533323 430 LQAVVGNNDVVLVKASRGMKLEEVITML 457
Cdd:TIGR01143 390 LKTLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
13-458 |
2.92e-124 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 384.06 E-value: 2.92e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 13 INGTGLAEQYEGITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLwmkdVANP--PENLPVIFVEDTL 90
Cdd:PRK11929 512 KGGSNSLQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAV----VERQvaDVDLPQIVVDDTR 587
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 91 LALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLAT---KFKVQKTEGNFNNHIGLPLTILNLEENTEVAVLEMGM 167
Cdd:PRK11929 588 AALGRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGM 667
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 168 SSRGEIEFLSKLARPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPlltnRVPEM---NLATETV 244
Cdd:PRK11929 668 NHPGEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDP----YTAIWaklAGARRVL 743
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 245 TFG-----DARANDYYPTTVTLQATGTHFKMN-REENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMT 318
Cdd:PRK11929 744 RFGlqpgaDVYAEKIAKDISVGEAGGTRCQVVtPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPV 823
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 319 GMRMEIVKKDSGLTVINDAYNASPTAMEAAFHLMNGLDGfSQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYG 398
Cdd:PRK11929 824 AGRMQRRRLSCGTRIIDDTYNANPDSMRAAIDVLAELPN-GPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLG 902
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 399 RLGAQIAEGAEinfPGERVKAYHnKEELVKDLQAVVGNNDVVLVKASRGMKLEEVITMLK 458
Cdd:PRK11929 903 EAARDAAAAFG---AGARGVCAS-VDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-298 |
2.46e-51 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 172.10 E-value: 2.46e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 111 VTGSNGKTSTKDIVTSLLATKFKVQKTEG--------NFNNHIGLPLTILNL-EENTEVAVLEMGMSSRGEiEFLSKLAR 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 182 PNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEM-NLATETVTFGDARANDYYPTTVT 260
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLkKAGVRVITYGIEGEADLRAANIE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446533323 261 LQATGTHFKMN--REENISFYIPVLGKHNVYNTLASMAIA 298
Cdd:pfam08245 160 LSSDGTSFDLFtvPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
77-425 |
6.35e-09 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 57.72 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 77 PPENLPVIFVEDtllALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKT--------EGNFNNHIGL- 147
Cdd:NF033197 66 PPDGKPFITHHE---AVGEILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLLHTsrgterypEGELSNKGSIt 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 148 PLTILNLEENTEvavlEMGMSSRGEIEF---LSKLARPNAAIITNIGEAHLMDLGSREAIAeAKLEIVAGLQEGGVFV-- 222
Cdd:NF033197 143 PASILNALELAE----EIGIDDYGFLIFevsLGGTGAGDVGIITNILEDYPIAGGKRSASA-AKLQSLKNAKVGSINVad 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 223 ---YNGDEPLLTNRVPemnlatetvtfgDARANDYYPTTVTLQATGTHFKMNreenisfyipVLGKHNVYNTLASMAIAK 299
Cdd:NF033197 218 lgiYINGKNKLVITVA------------GVEILSKYPLRFKYGNTEFEFNPL----------LFGPHYRENSLFAIEAAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 300 HFGVTWEEMKQGLVTLQMTGMRMEIVKKDsGLTVINdayNASP-----TAMEAAFHLMNGLDGfsqKIVVLGdmlelGDQ 374
Cdd:NF033197 276 NLGVDPEDIISALKGFKGLPGRMAVKKEG-GVVIVD---NINPglnvkAIEYALDDALELLGD---GTLVIG-----GDF 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446533323 375 EVqfhyeVGKLIDPAKISYVftygrLGAQIAEGAEINF----PGERVKAYHNKEE 425
Cdd:NF033197 344 GV-----VCEEIDIDKLSEV-----LKKYRPKIDILVGvgteLGKRLKKYLDKLE 388
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-458 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 595.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 2 INRTLKQVEQMINGTGLAEqyEGITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVanpPENL 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGD--PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL---PADL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 82 PVIFVEDTLLALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENTEVA 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 162 VLEMGMSSRGEIEFLSKLARPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEmnLAT 241
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAER--AKA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 242 ETVTFGDARANDYYPTTVTLQATGTHFKMN-REENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGM 320
Cdd:COG0770 234 RVLTFGLSEDADVRAEDIELDEDGTRFTLHtPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 321 RMEIVKKDSGLTVINDAYNASPTAMEAAFHLMNGLDGFSQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYGRL 400
Cdd:COG0770 314 RLEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGEL 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 446533323 401 GAQIAEGaeinFPGERVKAYHNKEELVKDLQAVVGNNDVVLVKASRGMKLEEVITMLK 458
Cdd:COG0770 394 ARAIAEA----AGGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALK 447
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
32-457 |
1.13e-154 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 445.17 E-value: 1.13e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 32 IDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVaNPPENLPVIFVEDTLLALQMLAKNYRDQLDVKVIGV 111
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREV-GPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 112 TGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENTEVAVLEMGMSSRGEIEFLSKLARPNAAIITNIG 191
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 192 EAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEmNLATETVTFGDARAnDYYPTTVTLQATG-THFKM 270
Cdd:TIGR01143 160 PAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKR-LPNRNILSFGFEGG-DFVAKDISYSALGsTSFTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 271 NREENISFY-IPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGMRMEIVKKDsGLTVINDAYNASPTAMEAAF 349
Cdd:TIGR01143 238 VAPGGEFEVsLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKN-GLTLIDDTYNANPDSMRAAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 350 HLMNGLDGfsQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYGRLGAQIAEgaeinFPGERVKAYHNKEELVKD 429
Cdd:TIGR01143 317 DALARFPG--KKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYD-----SFGKQGKHFADKDELLAF 389
|
410 420
....*....|....*....|....*...
gi 446533323 430 LQAVVGNNDVVLVKASRGMKLEEVITML 457
Cdd:TIGR01143 390 LKTLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
13-458 |
2.92e-124 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 384.06 E-value: 2.92e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 13 INGTGLAEQYEGITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLwmkdVANP--PENLPVIFVEDTL 90
Cdd:PRK11929 512 KGGSNSLQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAV----VERQvaDVDLPQIVVDDTR 587
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 91 LALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLAT---KFKVQKTEGNFNNHIGLPLTILNLEENTEVAVLEMGM 167
Cdd:PRK11929 588 AALGRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGM 667
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 168 SSRGEIEFLSKLARPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPlltnRVPEM---NLATETV 244
Cdd:PRK11929 668 NHPGEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDP----YTAIWaklAGARRVL 743
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 245 TFG-----DARANDYYPTTVTLQATGTHFKMN-REENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMT 318
Cdd:PRK11929 744 RFGlqpgaDVYAEKIAKDISVGEAGGTRCQVVtPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPV 823
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 319 GMRMEIVKKDSGLTVINDAYNASPTAMEAAFHLMNGLDGfSQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYG 398
Cdd:PRK11929 824 AGRMQRRRLSCGTRIIDDTYNANPDSMRAAIDVLAELPN-GPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLG 902
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 399 RLGAQIAEGAEinfPGERVKAYHnKEELVKDLQAVVGNNDVVLVKASRGMKLEEVITMLK 458
Cdd:PRK11929 903 EAARDAAAAFG---AGARGVCAS-VDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-458 |
1.55e-99 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 305.42 E-value: 1.55e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 1 MINRTLKQVEQMINGTGLAEQyegITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVanpPEN 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGAD---ITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPL---DID 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 81 LPVIFVEDTLLALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENTEV 160
Cdd:PRK10773 75 LPQLVVKDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 161 AVLEMGMSSRGEIEFLSKLARPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDepllTNRVP--EMN 238
Cdd:PRK10773 155 AVIELGANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNAD----SNDWLnwQSV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 239 LATETV-TFGDARAN--DYYPTTVTLQATGTHFKMNREE-NISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVT 314
Cdd:PRK10773 231 IGSKTVwRFSPNAANsvDFTATNIHVTSHGTEFTLHTPTgSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLAN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 315 LQMTGMRMEIVKKDSGLTVINDAYNASPTAMEAAFHLMNGLDGFsqKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYV 394
Cdd:PRK10773 311 LKAVPGRLFPIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGY--RVMVVGDMAELGAESEACHRQVGEAAKAAGIDKV 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446533323 395 FTYGRLGAQIAEGAEInfpGERvkaYHNKEELVKDLQAVVGNNDV--VLVKASRGMKLEEVITMLK 458
Cdd:PRK10773 389 LSVGKLSHAISEASGV---GEH---FADKTALIARLKALLAEHQVitILVKGSRSAAMEEVVRALQ 448
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
5-457 |
3.36e-77 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 256.81 E-value: 3.36e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 5 TLKQVEQMINGTGLAEqyEGITIQGVSIDTRKIEKGN--LYVPIQGERFDGHAFVDKAVENGA----VATLWMKDVANPP 78
Cdd:PRK11930 4 TLESISGILGAEGLGD--KDAIIDQILTDSRSLSFPEntLFFALKGERNDGHRYIQELYEKGVrnfvVSEEKHPEESYPD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 79 ENLpvIFVEDTLLALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENT 158
Cdd:PRK11930 82 ANF--LKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 159 EVAVLEMGMSSRGEIEFLSKLARPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAglqEGGVFVYNGDEPLLTNRVPEMN 238
Cdd:PRK11930 160 ELGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFK---DCDVIIYNGDNELISSCITKSN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 239 LATETVTFGDARAN-DYYPTTVTLQATGTHFKM-NREENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQ 316
Cdd:PRK11930 237 LTLKLISWSRKDPEaPLYIPFVEKKEDHTVISYtYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 317 MTGMRMEIVKKDSGLTVINDAYNASPTAMEAAFHLMNGLDGFSQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFT 396
Cdd:PRK11930 317 PVAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNRRSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446533323 397 ygrLGAQIAEGAEInFPGERVKAYHNKEELVKDLQAVVGNNDVVLVKASRGMKLEEVITML 457
Cdd:PRK11930 397 ---IGEEISSEASK-FEGTEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
27-457 |
9.87e-76 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 244.68 E-value: 9.87e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 27 IQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGA-VATLWMKDVANPPENLPVIFVEDTLLALQMLAKNYRDQLD 105
Cdd:PRK14093 28 VTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAaLAVVERAQRDKFAADAPLLVVDDVLAALRDLGRAARARLE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 106 VKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNHIGLPLTILNLEENTEVAVLEMGMSSRGEIEFLSKLARPNAA 185
Cdd:PRK14093 108 AKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 186 IITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPL---LTNRVPEMNLAtETVTFGDARANDYYPTTVTLQ 262
Cdd:PRK14093 188 IITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQfdrLAASARAAGIA-RIVSFGADEKADARLLDVALH 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 263 ATGTHFKMN-REENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMT---GMRMEIVKKDSGLTVINDAY 338
Cdd:PRK14093 267 ADCSAVHADiLGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAagrGVRHTLEVGGGEATLIDESY 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 339 NASPTAMEAAFHLMN--GLDGFSQKIVVLGDMLELGDQEVQFHYEVGKLIDPAKISYVFTYGRLGAQIAEGaeinFPGER 416
Cdd:PRK14093 347 NANPASMAAALGVLGraPVGPQGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVFCCGPLMRNLWDA----LSSGK 422
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 446533323 417 VKAY-HNKEELVKDLQAVVGNNDVVLVKASRGMKLEEVITML 457
Cdd:PRK14093 423 RGGYaEDAAALESQVVAAIRAGDVIMVKGSLGSRMKTIVTAL 464
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-298 |
2.46e-51 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 172.10 E-value: 2.46e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 111 VTGSNGKTSTKDIVTSLLATKFKVQKTEG--------NFNNHIGLPLTILNL-EENTEVAVLEMGMSSRGEiEFLSKLAR 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 182 PNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEM-NLATETVTFGDARANDYYPTTVT 260
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLkKAGVRVITYGIEGEADLRAANIE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446533323 261 LQATGTHFKMN--REENISFYIPVLGKHNVYNTLASMAIA 298
Cdd:pfam08245 160 LSSDGTSFDLFtvPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
29-348 |
2.67e-51 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 179.89 E-value: 2.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 29 GVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVANPPENLPVIFVEDTLLALQMLAKNYRDQ--LDV 106
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAAGVPVIVVPDPRAALALLAAAFYGHpsQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 107 KVIGVTGSNGKTSTKDIVTSLL-ATKFKVqkteGNF---NNHIG-----LPLT---------ILN--LEENTEVAVLEmg 166
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILrALGKKT----GLIgtvGNGIGgelipSSLTtpealdlqrLLAemVDAGVTHVVME-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 167 MSSRG-------EIEFlsklarpNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPlltnRVPEM-- 237
Cdd:COG0769 155 VSSHAldqgrvdGVRF-------DVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDP----YGRRLaa 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 238 NLATETVTFGDARANDYYPTTVTLQATGTHFKMN-REENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQ 316
Cdd:COG0769 224 AAPARVITYGLKADADLRATDIELSADGTRFTLVtPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLK 303
|
330 340 350
....*....|....*....|....*....|...
gi 446533323 317 M-TGmRMEIVKKDSGLTVINDaYNASPTAMEAA 348
Cdd:COG0769 304 GvPG-RMERVDGGQGPTVIVD-YAHTPDALENV 334
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
24-349 |
3.31e-43 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 158.25 E-value: 3.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 24 GITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVANPPENLPVIFVEDTLLALQMLAKNYRDQ 103
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAPVPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 104 L--DVKVIGVTGSNGKTSTkdivTSLLATKFKVQK-------TEGNF---NNHIGLP--------LTIL-----NLEENT 158
Cdd:TIGR01085 81 PskKLKVIGVTGTNGKTTT----TSLIAQLLRLLGkktgligTIGYRlggNDLIKNPaalttpeaLTLQstlaeMVEAGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 159 EVAVLEmgMSSRG-------EIEFlsklarpNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPL-- 229
Cdd:TIGR01085 157 QYAVME--VSSHAlaqgrvrGVRF-------DAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYga 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 230 -LTNRVPEMNLATETVTFGDARANDYYPTTVTLQATGTHFKM-NREENISFYIPVLGKHNVYNTLASMAIAKHFG-VTWE 306
Cdd:TIGR01085 228 qFVKRLPKDITVSAITQPADGRAQDIKITDSGYSFEGQQFTFeTPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLE 307
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446533323 307 EMKQGLVTLQMTGMRMEIVKKDSGLTVINDaYNASPTAMEAAF 349
Cdd:TIGR01085 308 DIVAALEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKAL 349
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
105-441 |
9.72e-37 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 139.78 E-value: 9.72e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 105 DVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNfnnhIGLPLTILNLEENTEVAVLEMgmsSRGEIEFLSKLaRPNA 184
Cdd:TIGR01087 101 PLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLEL---SSFQLETTESL-RPEI 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 185 AIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNrvPEMNLATETVTFGDARANDYYPTTVTlqaT 264
Cdd:TIGR01087 173 ALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFAR--LAQKSKAQVIWFSVEKDAERGLCIRD---G 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 265 GTHFKMNREEnisfyIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGMRMEIVKKDSGLTVINDAYNASPTA 344
Cdd:TIGR01087 248 GLYLKPNDLE-----GSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDSKATNVHA 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 345 MEAAfhlmngLDGFSQKIVVL--GDmlelgDQEVQFHYEVGKLIDPAKIsyVFTYGRLGAQIAEGA-EINFPGERVKayh 421
Cdd:TIGR01087 323 TLAA------LSAFDNPVILIvgGD-----DKGADFSPLAPAAAGKVKA--VLAIGEDAAKIAPLLkEAGLSVYLVE--- 386
|
330 340
....*....|....*....|
gi 446533323 422 NKEELVKDLQAVVGNNDVVL 441
Cdd:TIGR01087 387 SLEEAVQAAREVASPGDVVL 406
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
18-349 |
2.98e-36 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 139.11 E-value: 2.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 18 LAEQYEGITIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVAnPPENLPVIFVEDTLLALQMLA 97
Cdd:PRK00139 6 LRDLLAPVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGE-AGTGVPVIIVPDLRKALALLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 98 KNY--RDQLDVKVIGVTGSNGKTSTKDIVTSLL-ATKFK--VQKTEGNF--NNHIGLPLT---ILNL--------EENTE 159
Cdd:PRK00139 85 AAFygHPSDKLKLIGVTGTNGKTTTAYLLAQILrLLGEKtaLIGTLGNGigGELIPSGLTtpdALDLqrllaelvDAGVT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 160 VAVLEmgMSSRG-------EIEFlsklarpNAAIITNIGEAHLmDL-GSREAIAEAKLEIVAGLqeGGVFVYNGDEPLLt 231
Cdd:PRK00139 165 YAAME--VSSHAldqgrvdGLKF-------DVAVFTNLSRDHL-DYhGTMEDYLAAKARLFSEL--GLAAVINADDEVG- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 232 nrvPEMNLATETVTFGDARAnDYYPTTVTLQATGTHFKMNREenisFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQG 311
Cdd:PRK00139 232 ---RRLLALPDAYAVSMAGA-DLRATDVEYTDSGQTFTLVTE----VESPLIGRFNVSNLLAALAALLALGVPLEDALAA 303
|
330 340 350
....*....|....*....|....*....|....*....
gi 446533323 312 LVTLQMTGMRMEIVKKDSGLTVIND-AYNasPTAMEAAF 349
Cdd:PRK00139 304 LAKLQGVPGRMERVDAGQGPLVIVDyAHT--PDALEKVL 340
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
104-441 |
7.46e-36 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 137.52 E-value: 7.46e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 104 LDVKVIGVTGSNGKTSTkdivTSLLATKFKV--QKTE--GNfnnhIGLP-LTILNLEENTEVAVLEMgmSSRgEIEFLSK 178
Cdd:COG0771 103 SPAPIIAITGTNGKTTT----TTLIGHILKAagLRVAvgGN----IGTPlLDLLLEPEPPDVYVLEL--SSF-QLETTPS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 179 LaRPNAAIITNIGEAHLmDL-GSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEMNLATETVTFGDARANDYY-- 255
Cdd:COG0771 172 L-RPDVAVILNITPDHL-DRhGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPFSLKEPLEGGAGle 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 256 PTTVTLQATGtHFKMNREEnisfyIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQmtGM--RMEIVKKDSGLTV 333
Cdd:COG0771 250 DGKLVDRASG-EELLPVDD-----LRLPGRHNLENALAALAAARALGVPPEAIREALRSFK--GLphRLEFVAEINGVRF 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 334 IND--AYNasPTAMEAAfhlmngLDGFSQKIVVL-------GDMLELgdqeVQFHYEvgklidpaKISYVFTYGRLGAQI 404
Cdd:COG0771 322 INDskATN--PDATLAA------LESFDGPVVLIaggldkgADFSPL----APAVAE--------RVKAVVLIGEDAEKI 381
|
330 340 350
....*....|....*....|....*....|....*...
gi 446533323 405 AE-GAEINFPGERVkayHNKEELVKDLQAVVGNNDVVL 441
Cdd:COG0771 382 AAaLAGAGVPVVIV---ETMEEAVAAAAELARPGDVVL 416
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
94-442 |
9.29e-33 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 129.03 E-value: 9.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 94 QMLAKNYRDQldvKVIGVTGSNGKTSTkdivTSLLATKFKvqktegnfnnHIGLPLTIL------NLEENtevAVLemgm 167
Cdd:COG0773 95 EMLAELMRGK---RSIAVAGTHGKTTT----TSMLAHILE----------EAGLDPTFLiggilnNFGTN---ARL---- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 168 sSRGE---IE-------FLsKLaRPNAAIITNIgEA-HlMDL-GSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVP 235
Cdd:COG0773 151 -GDGDyfvAEadesdgsFL-HY-SPDIAVVTNI-EAdH-LDIyGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLP 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 236 EmnLATETVTFGDARANDYYPTTVTLQATGTHFKMNREENI--SFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLV 313
Cdd:COG0773 226 R--CGRPVITYGFSEDADYRAENIRIDGGGSTFDVLRRGEElgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALA 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 314 TLQMTGMRMEIVKKDSGLTVINDaYNASPTAMEAAfhlmngLDGF-----SQKIVV---------LGDM-------LELG 372
Cdd:COG0773 304 SFKGVKRRFELKGEVGGVTVIDD-YAHHPTEIAAT------LAAArekypDRRLVAvfqphrysrTRDFldefaeaLSLA 376
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446533323 373 DQ----EVqfhYEVGKLIDPAkISyvftygrlGAQIAEgaEINFPGERVKAYHNKEELVKDLQAVVGNNDVVLV 442
Cdd:COG0773 377 DEvillDI---YAAREKPIPG-VS--------SEDLAE--AIRKRGKDVVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-348 |
6.52e-28 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 117.50 E-value: 6.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 27 IQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVANPPENLP--VIFVEDTLLALQMLAKNYRDQ- 103
Cdd:PRK11929 29 TADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAADalVLPVADLRKALGELAARWYGRp 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 104 -LDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKTEGNFNNH-----IGLPLT---------ILN--LEENTEVAVLEmg 166
Cdd:PRK11929 109 sEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARldgrlIPGSLTtpdaiilhrILArmRAAGADAVAME-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 167 MSSRG-EIEFLSKLaRPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVPEMNLATETVT 245
Cdd:PRK11929 187 ASSHGlEQGRLDGL-RIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALPRGLKVGY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 246 FGDARANDYYPTTVTLQATGTHFKM-NREENISFYIPVLGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGMRMEI 324
Cdd:PRK11929 266 SPQNAGADVQARDLRATAHGQVFTLaTPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMER 345
|
330 340
....*....|....*....|....*..
gi 446533323 325 VKK---DSGLTVINDaYNASPTAMEAA 348
Cdd:PRK11929 346 VGPtagAQGPLVVVD-YAHTPDALAKA 371
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
107-441 |
4.41e-20 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 92.34 E-value: 4.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 107 KVIGVTGSNGKTSTkdivTSLLATKFKVQ--KT--EGNfnnhIGLPL--TILNLEENTeVAVLEMgmsSRGEIEFLSKLa 180
Cdd:PRK14106 109 PIVAITGTNGKTTT----TTLLGEIFKNAgrKTlvAGN----IGYPLidAVEEYGEDD-IIVAEV---SSFQLETIKEF- 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 181 RPNAAIITNIGEAHLMDLGSREAIAEAKLEIVAGLQEGGVFVYNGDEPL---LTNRVPemnlaTETVTFgdARANDYYPT 257
Cdd:PRK14106 176 KPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRtrsLAKKAK-----ARVIFF--SRKSLLEEG 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 258 T------VTLQATGTHFKMNREENIsfYIPvlGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGMRMEIVKKDSGL 331
Cdd:PRK14106 249 VfvkngkIVISLGGKEEEVIDIDEI--FIP--GEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGV 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 332 TVINDAYNASPTAMEAAfhlmngLDGFSQKIVVLGdmlelG--DQEVQFHyEVGKLIDpAKISYVFTYGRLGAQIAEGAE 409
Cdd:PRK14106 325 KFINDSKGTNPDAAIKA------LEAYETPIVLIA-----GgyDKGSDFD-EFAKAFK-EKVKKLILLGETAQEIAEAAR 391
|
330 340 350
....*....|....*....|....*....|...
gi 446533323 410 -INFpgERVKAYHNKEELVKDLQAVVGNNDVVL 441
Cdd:PRK14106 392 kYGF--DNILFAETLEEAVKKAYEIAKPGDVVL 422
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
26-101 |
1.45e-13 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 65.72 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 26 TIQGVSIDTRKIEKGNLYVPIQGERFDGHAFVDKAVENGAVATLWMKDVAN--------PPENLPVIFVEDTLLALQMLA 97
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNispdnpelEAAKVPGIPVIDRREALAELA 80
|
....
gi 446533323 98 KNYR 101
Cdd:pfam01225 81 AAFY 84
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
318-405 |
1.86e-11 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 60.05 E-value: 1.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 318 TGMRMEIVKKDSGLTVINDaYNASPTAMEAAFHLMNGLDGfSQKIVVLGDMlelGDQEVQFHYEVGKLIDPAKISYVFT- 396
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFP-GRLILVFGGM---GDRDAEFHALLGRLAAALADVVILTg 75
|
90
....*....|
gi 446533323 397 -YGRLGAQIA 405
Cdd:pfam02875 76 dYPRAEDPGA 85
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
13-340 |
1.22e-10 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 63.13 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 13 INGTGLAEQYEGITIQGVSIDTRKIEKGNLYVpIQGERFDgHAFVDKAVENGavatLWMKDVANPPE-NLPVIFVEDTLL 91
Cdd:PRK14022 20 IDQDHYHYNYSGVQFDDISYDSRTADEGTLFF-AKGAYFK-HKFLQNAITQG----LKLYVSEKDYEvGIPQVIVPDIKK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 92 ALQMLAKNYRD--QLDVKVIGVTGSNGKTS----TKDIV-----TSLLATKFKVQKTEGNFNNHIGLPLTiLNLEENTEV 160
Cdd:PRK14022 94 AMSLIAMEFYDnpQHKLKLLAFTGTKGKTTaayfAYHILkqlhkPAMLSTMNTTLDGETFFKSALTTPES-LDLFKMMAE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 161 AV------LEMGMSSRG-------EIEFlsklarpNAAIITNIGEAHL--MDLGSREAIAEAKLEIVAglQEGGVFVYNG 225
Cdd:PRK14022 173 AVdngmthLIMEVSSQAylvgrvyGLTF-------DVGVFLNITPDHIgpIEHPTFEDYFYHKRLLME--NSKAVVVNSD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 226 DE--PLLTNRVPEmnlaTETVTFGDARANDY-YPTTVTLQATGTHFKmnreeniSFYIPVLGKHNVYNTLASMAIAKHFG 302
Cdd:PRK14022 244 MDhfSELLEQVTP----QEHDFYGIDSENQImASNAFSFEATGKLAG-------TYDIQLIGKFNQENAMAAGLACLRLG 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 446533323 303 VTWEEMKQGLVTLQMTGmRMEIVKKDSGLTVIND-AYNA 340
Cdd:PRK14022 313 ASLEDIQKGIAQTPVPG-RMEVLTQSNGAKVFIDyAHNG 350
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
109-323 |
1.62e-09 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 60.22 E-value: 1.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 109 IGVTGSNGKTSTKDIVTSLLATkfkVQKTE----GNFNNhiglpLTILNLEENTEVAVLEMGmSSRGEIEFLSklarPNA 184
Cdd:PRK14573 107 ILVSGSHGKTTVSSLITAIFQE---AKKDPsyaiGGLNQ-----EGLNGYSGSSEYFVAEAD-ESDGSLKHYT----PEF 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 185 AIITNIGEAHLMDL-GSREAIAEAKLEIVAGLQEGGVFVYNGDEPLLTNRVpemnlatETVTFGDARANDYYPTTVTLQA 263
Cdd:PRK14573 174 SVITNIDNEHLSNFeGDRELLLASIQDFARKVQQINKCFYNGDCPRLKGCL-------QGHSYGFSSSCDLHILSYYQEG 246
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446533323 264 TGTHFKMNREENISFYIPV--LGKHNVYNTLASMAIAKHFGVTWEEMKQGLVTLQMTGMRME 323
Cdd:PRK14573 247 WRSYFSAKFLGVVYQDIELnlVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLE 308
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
77-425 |
6.35e-09 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 57.72 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 77 PPENLPVIFVEDtllALQMLAKNYRDQLDVKVIGVTGSNGKTSTKDIVTSLLATKFKVQKT--------EGNFNNHIGL- 147
Cdd:NF033197 66 PPDGKPFITHHE---AVGEILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLLHTsrgterypEGELSNKGSIt 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 148 PLTILNLEENTEvavlEMGMSSRGEIEF---LSKLARPNAAIITNIGEAHLMDLGSREAIAeAKLEIVAGLQEGGVFV-- 222
Cdd:NF033197 143 PASILNALELAE----EIGIDDYGFLIFevsLGGTGAGDVGIITNILEDYPIAGGKRSASA-AKLQSLKNAKVGSINVad 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 223 ---YNGDEPLLTNRVPemnlatetvtfgDARANDYYPTTVTLQATGTHFKMNreenisfyipVLGKHNVYNTLASMAIAK 299
Cdd:NF033197 218 lgiYINGKNKLVITVA------------GVEILSKYPLRFKYGNTEFEFNPL----------LFGPHYRENSLFAIEAAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533323 300 HFGVTWEEMKQGLVTLQMTGMRMEIVKKDsGLTVINdayNASP-----TAMEAAFHLMNGLDGfsqKIVVLGdmlelGDQ 374
Cdd:NF033197 276 NLGVDPEDIISALKGFKGLPGRMAVKKEG-GVVIVD---NINPglnvkAIEYALDDALELLGD---GTLVIG-----GDF 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446533323 375 EVqfhyeVGKLIDPAKISYVftygrLGAQIAEGAEINF----PGERVKAYHNKEE 425
Cdd:NF033197 344 GV-----VCEEIDIDKLSEV-----LKKYRPKIDILVGvgteLGKRLKKYLDKLE 388
|
|
| PLN02913 |
PLN02913 |
dihydrofolate synthetase |
155-212 |
4.60e-05 |
|
dihydrofolate synthetase
Pssm-ID: 178501 [Multi-domain] Cd Length: 510 Bit Score: 45.58 E-value: 4.60e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446533323 155 EENTEVAVLEMGMS-SRGEIEFL--SKLArpnAAIITNIGEAHLMDL-GSREAIAEAKLEIV 212
Cdd:PLN02913 171 QENVDIAVIEAGLGgARDATNVIdsSGLA---ASVITTIGEEHLAALgGSLESIALAKSGII 229
|
|
| |
