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Conserved domains on  [gi|446533942|ref|WP_000611288|]
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MULTISPECIES: two-component system response regulator DcuR [Enterobacteriaceae]

Protein Classification

two-component system response regulator DcuR( domain architecture ID 11484718)

two-component system response regulator DcuR is a member of the two-component regulatory system DcuR/DcuS that is involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10430 PRK10430
two-component system response regulator DcuR;
1-239 0e+00

two-component system response regulator DcuR;


:

Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 508.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:PRK10430   1 MINVLIVDDDAMVAELNRRYVAQIPGFQCCGTASTLEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLT 160
Cdd:PRK10430  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLT 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446533942 161 PQTLRTLCQWIDAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRIQAEHYSLLKQYCQ 239
Cdd:PRK10430 161 PQTLRTLCQWIDAHQDYEFSTDELANAVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRLQAEHYSLLKQYCQ 239
 
Name Accession Description Interval E-value
PRK10430 PRK10430
two-component system response regulator DcuR;
1-239 0e+00

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 508.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:PRK10430   1 MINVLIVDDDAMVAELNRRYVAQIPGFQCCGTASTLEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLT 160
Cdd:PRK10430  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLT 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446533942 161 PQTLRTLCQWIDAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRIQAEHYSLLKQYCQ 239
Cdd:PRK10430 161 PQTLRTLCQWIDAHQDYEFSTDELANAVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRLQAEHYSLLKQYCQ 239
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-121 1.19e-59

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 183.99  E-value: 1.19e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLL--KERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWR 121
Cdd:cd19925   79 VVTAANDVETVREALRLGVVDYLIKPFTFERLRQRLERYR 118
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-134 1.11e-51

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 164.37  E-value: 1.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALL--AEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYD 134
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEED 134
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-117 3.55e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.50  E-value: 3.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942    4 VLIIDDDAMVAELNRRYVaQIPGFQCcGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGYVV-AEADDGKEALELLKEER--PDLILLDINMPGMDGLELLKRIRRRDPTTPVIIL 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446533942   84 SSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:pfam00072  77 TAHGDEDDAVEALEAGADDFLSKPFDPDELLAAI 110
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-59 5.73e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.56  E-value: 5.73e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446533942     2 INVLIIDDDAMVAELNRRYVAQiPGFQcCGTASTLEKAKEIIfnSDTPIDLILLDIYM 59
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEK-EGYE-VDEATDGEEALELL--KEEKPDLILLDIMM 54
 
Name Accession Description Interval E-value
PRK10430 PRK10430
two-component system response regulator DcuR;
1-239 0e+00

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 508.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:PRK10430   1 MINVLIVDDDAMVAELNRRYVAQIPGFQCCGTASTLEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLT 160
Cdd:PRK10430  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEQDPRRLPKGLT 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446533942 161 PQTLRTLCQWIDAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRIQAEHYSLLKQYCQ 239
Cdd:PRK10430 161 PQTLRTLCQWIDAHQDYEFSTDELANAVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRLQAEHYSLLKQYCQ 239
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-121 1.19e-59

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 183.99  E-value: 1.19e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLL--KERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWR 121
Cdd:cd19925   79 VVTAANDVETVREALRLGVVDYLIKPFTFERLRQRLERYR 118
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-134 1.11e-51

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 164.37  E-value: 1.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALL--AEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYD 134
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEED 134
dpiA PRK10046
two-component response regulator DpiA; Provisional
 2-225 4.11e-33

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 119.35  E-value: 4.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:PRK10046   5 LTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMI-ERFKP-GLILLDNYLPDGRGINLLHELVQAHYPGDVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIHGSSSNEqdPR-RLPKGLT 160
Cdd:PRK10046  83 FTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGE--PKdELPTGID 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446533942 161 PQTLRTLCQWIdAHQDYEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYR 225
Cdd:PRK10046 161 PLTLNAVRKLF-KEPGVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-117 7.13e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 97.96  E-value: 7.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELL--EEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPI 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446533942  81 IVISSAADAATikDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:COG3279   79 IFTTAYDEYAL--EAFEVNAVDYLLKPIDEERLAKAL 113
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-155 2.74e-23

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 96.96  E-value: 2.74e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERA-GYEVE-TAASGEEALALL--REEPPDLVLLDLRMPGMDGLELLRELRALDPDLPV 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALtgwrqkKMALEKHQYYDQAELDQLIHGSSSNEQDPRRL 155
Cdd:COG2204   78 ILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAV------ERALERRRLRRENAEDSGLIGRSPAMQEVRRL 146
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-107 3.70e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 87.14  E-value: 3.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIV 82
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELL--EEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIII 78

                         90       100
                 ....*....|....*....|....*
gi 446533942  83 ISSAADAATIKDSLHYGVVDYLIKP 107
Cdd:COG4753   79 LSGYSDFEYAQEAIKLGADDYLLKP 103
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-123 3.36e-19

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 80.07  E-value: 3.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQI-PGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIV 82
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEeLGFEVVGEAENGEEALELI--EEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIII 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446533942  83 ISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQK 123
Cdd:cd17536   79 LSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEE 119
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-120 9.69e-19

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 79.12  E-value: 9.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSD- 79
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELL--RAGPPDLILLDINMPGMDGLELLRRIRALPRLPDi 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446533942  80 -VIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGW 120
Cdd:COG0784   81 pIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-107 1.10e-18

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 78.04  E-value: 1.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   5 LIIDDDAMVAELNRRYVAQIpGFQCcGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVIS 84
Cdd:cd00156    1 LIVDDDPAIRELLKSLLERE-GYEV-DTAADGEEALELL--REERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLT 76

                         90       100
                 ....*....|....*....|...
gi 446533942  85 SAADAATIKDSLHYGVVDYLIKP 107
Cdd:cd00156   77 AKADEEDAVRALELGADDYLVKP 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 3-143 1.36e-17

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 78.67  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSD--V 80
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTL-GYDVV-TAESGEEALELL--LEAPPDLILLDVRMPGMDGFELLRLLRADPSTRDipV 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL-TGWRQKKMALEKHQYYDQAELDQLIH 143
Cdd:COG3437   84 IFLTALADPEDRERALEAGADDYLTKPFDPEELLARVrNALELRRLQRELDDLVLYLKLAAPLH 147
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-117 3.55e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.50  E-value: 3.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942    4 VLIIDDDAMVAELNRRYVaQIPGFQCcGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGYVV-AEADDGKEALELLKEER--PDLILLDINMPGMDGLELLKRIRRRDPTTPVIIL 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446533942   84 SSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:pfam00072  77 TAHGDEDDAVEALEAGADDFLSKPFDPDELLAAI 110
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-117 4.85e-16

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 73.40  E-value: 4.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSD- 79
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAA-GYEVV-EAADGEEALELL--QEHRPDLILLDLEMPDMDGLELCRRLRADPRTADi 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446533942  80 -VIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:COG3706   77 pIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-108 4.06e-15

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 71.53  E-value: 4.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALERE-GYEVD-TAADGEEALELL--EEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPI 76

                         90       100
                 ....*....|....*....|....*...
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:COG0745   77 IMLTARDDEEDRVRGLEAGADDYLTKPF 104
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 2-107 6.84e-15

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 68.57  E-value: 6.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTAST----LEKAKEiifnsDTPiDLILLDIYMQKENGLDLLPVLhNARCK 77
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDgeeaLEKIKE-----LKP-DVITLDIEMPVMDGLEALRRI-MAERP 73

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446533942  78 SDVIVISS--AADAATIKDSLHYGVVDYLIKP 107
Cdd:cd17541   74 TPVVMVSSltEEGAEITLEALELGAVDFIAKP 105
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-119 1.14e-14

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 69.56  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAE-----LNRRyvaqipGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCK 77
Cdd:COG4567    6 SLLLVDDDEAFARvlaraLERR------GFEVT-TAASVEEALALL--EQAPPDYAVLDLRLGDGSGLDLIEALRERDPD 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446533942  78 SDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTG 119
Cdd:COG4567   77 ARIVVLTGYASIATAVEAIKLGADDYLAKPADADDLLAALER 118
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 3-117 8.00e-14

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 65.54  E-value: 8.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAE-----LNRRyvaqipGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCK 77
Cdd:cd17563    2 SLLLVDDDEVFAErlaraLERR------GFEVE-TAHSVEEALALA--REEKPDYAVLDLRLGGDSGLDLIPPLRALQPD 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446533942  78 SDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17563   73 ARIVVLTGYASIATAVEAIKLGADDYLAKPADADEILAAL 112
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 2-117 1.41e-13

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 64.99  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDdamvAELNRRYVAQI---PGFQCCGTAST----LEKAKEIifnsdtPIDLILLDIYMQKENGLDLL----PV 70
Cdd:cd17542    1 KKVLIVDD----AAFMRMMLKDIltkAGYEVVGEAANgeeaVEKYKEL------KPDLVTMDITMPEMDGIEALkeikKI 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446533942  71 LHNARcksdVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17542   71 DPNAK----VIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAV 113
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-117 2.82e-13

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 64.07  E-value: 2.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALL--RELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVL 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17535   79 TAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAI 112
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-141 3.30e-13

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 65.75  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIpGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSdV 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREA-GYEVVAEAADGEDAVELV--RELKPDLVIVDIDMPDRDGLEAARQISEERPAP-V 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTgwrqkkMALEKHQYYDQ--AELDQL 141
Cdd:COG3707   79 ILLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALE------LALARFRELRAlrRELAKL 135
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 4-117 5.55e-13

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 63.33  E-value: 5.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFnsDTPIDLILLDIYMQKENGLDLLPVLHNaRCKSDVIVI 83
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIE--ELKPDVVFLDIQMPGLDGLELAKKLSK-LAKPPLIVF 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446533942  84 SSAADAATIKdSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17532   78 VTAYDEYAVE-AFELNAVDYLLKPFSEERLAEAL 110
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 4-115 2.23e-12

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 61.88  E-value: 2.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNarcKSD--VI 81
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRC-GYQVT-TCTDAEEALSMLRENKDEFDLVITDVHMPDMDGFEFLELIRL---EMDlpVI 75

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFqasRFEE 115
Cdd:cd17584   76 MMSADGSTSTVMKGLAHGACDYLLKPV---SIED 106
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-108 3.28e-12

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 61.31  E-value: 3.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVaQIPGFQCCGTASTLEKAKEIifnSDTPIDLILLDIYMQKENGLDLLPVLhnaRCKSDVIVI 83
Cdd:cd17594    2 VLVVDDDAAMRHLLILYL-RERGFDVTAAADGAEEARLM---LHRRVDLVLLDLRLGQESGLDLLRTI---RARSDVPII 74

                         90       100
                 ....*....|....*....|....*...
gi 446533942  84 SSAADAATIKD---SLHYGVVDYLIKPF 108
Cdd:cd17594   75 IISGDRRDEIDrvvGLELGADDYLAKPF 102
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-71 4.88e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 61.45  E-value: 4.88e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVL 71
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELL--EELRPDVVLLDIRMPGMDGLEALRRL 69
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-127 5.64e-12

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 60.88  E-value: 5.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIpGFQCCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKE-NGLDLLPVLHNarcKSD- 79
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILESL-GYEVVGIADSGEEAIELA--EENKPDLILMDINLKGDmDGIEAAREIRE---KFDi 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446533942  80 -VIVISSAADAATI---KDSLHYGvvdYLIKPFQASRFEEALtgwrqkKMAL 127
Cdd:cd17534   75 pVIFLTAYSDEETLeraKETNPYG---YLVKPFNERELKAAI------ELAL 117
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-113 8.88e-11

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 57.45  E-value: 8.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQIPGFQCCGTAS---TLEKAKEiifnsdTPIDLILLDIYMQKENGLDLLPVLHNARCKSD 79
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVSFTDpreALAWCRE------NPPDLILLDYMMPGMDGLEFIRRLRALPGLED 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446533942  80 V--IVISSAADAATIKDSLHYGVVDYLIKPFQASRF 113
Cdd:cd17551   76 VpiVMITADTDREVRLRALEAGATDFLTKPFDPVEL 111
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-114 8.97e-11

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 57.59  E-value: 8.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQCCgTASTLEKAkeIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSD-EGYKVT-HVETGKEA--LAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVI 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIKPFQASRFE 114
Cdd:cd17572   77 TAHGSVDIAVEAMRLGAYDFLEKPFDADRLR 107
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-108 3.19e-10

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 59.48  E-value: 3.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:PRK11361   7 ILIVDDEDNV----RRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILM 82

                         90       100
                 ....*....|....*....|....*
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:PRK11361  83 TAYAEVETAVEALRCGAFDYVIKPF 107
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-108 6.16e-10

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 58.24  E-value: 6.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTAST----LEKAKEIifnsdTPiDLILLDIYMQKENGLDLLPVLHnARC 76
Cdd:PRK00742   3 KIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDgleaREKIKKL-----NP-DVITLDVEMPVMDGLDALEKIM-RLR 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446533942  77 KSDVIVISS----AADaATIkDSLHYGVVDYLIKPF 108
Cdd:PRK00742  76 PTPVVMVSSlterGAE-ITL-RALELGAVDFVTKPF 109
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 4-109 9.05e-10

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 54.51  E-value: 9.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQCCGTASTLEKAkeIIFNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:cd17555    3 ILVIDDDEVVRESIAAYLED-SGFQVLQAADGRQGL--ELFRSEQP-DLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78

                         90       100
                 ....*....|....*....|....*.
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIKPFQ 109
Cdd:cd17555   79 SGAGVMSDAVEALRLGAWDYLTKPIE 104
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-131 1.43e-09

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 54.42  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVAQ---IPGFQCCGTASTlEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:cd17549    1 VLLVDDDADV----REALQQtleLAGFRVRAFADA-EEALAAL-SPDFP-GVVISDIRMPGMDGLELLAQIRELDPDLPV 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALtgwrqkKMALEKHQ 131
Cdd:cd17549   74 ILITGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVV------RRALEKRR 118
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-108 1.51e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 54.23  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFqCCGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDllpVLHNARCKSDVIVI 83
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEM-EGF-NVRAAHDGEQGLAALLEGS--PDLVVLDVMLPKMNGLD---VLKELRKTSQVPVL 73

                         90       100
                 ....*....|....*....|....*..
gi 446533942  84 SSAADAATIKD--SLHYGVVDYLIKPF 108
Cdd:cd17623   74 MLTARGDDIDRilGLELGADDYLPKPF 100
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-107 2.36e-09

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 56.43  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERC-AAQPP-DVILMDLEMPRMDGVEATRRIMAERPCPILI 78

                         90       100
                 ....*....|....*....|....*..
gi 446533942  82 VISS-AADAATIKDSLHYGVVDYLIKP 107
Cdd:PRK12555  79 VTSLtERNASRVFEAMGAGALDAVDTP 105
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-167 4.14e-09

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 55.03  E-value: 4.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVAQ----IPGFQCCGTASTLEKAKEIIFNSDtPiDLILLDIYMQKENGLDLLPVLHNARCKSD 79
Cdd:PRK10651   9 ILLIDDHPML----RTGVKQlismAPDITVVGEASNGEQGIELAESLD-P-DLILLDLNMPGMNGLETLDKLREKSLSGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  80 VIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEkhqyydqaelDQLIHGSSSNEQDPRRLPK-- 157
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLS----------EALTPVLAASLRANRATTErd 152

                        170
                 ....*....|..
gi 446533942 158 --GLTPQTLRTL 167
Cdd:PRK10651 153 vnQLTPRERDIL 164
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-117 8.03e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 52.42  E-value: 8.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRyvaqipGFQCCGTASTLEKAK------EIIFNSDTPI-----DLILLDIYMQKENGLDLLpvl 71
Cdd:cd17557    1 TILLVEDNPGDAELIQE------AFKEAGVPNELHVVRdgeealDFLRGEGEYAdaprpDLILLDLNMPRMDGFEVL--- 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446533942  72 hnARCKSD-------VIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17557   72 --REIKADpdlrripVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAI 122
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-107 1.29e-08

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 50.87  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   5 LIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVIS 84
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKE-GYEVD-TAADGEEALELA--REEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLT 76

                         90       100
                 ....*....|....*....|...
gi 446533942  85 SAADAATIKDSLHYGVVDYLIKP 107
Cdd:cd17574   77 AKDEEEDKVLGLELGADDYITKP 99
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-113 2.27e-08

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 50.96  E-value: 2.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVAQI---PGFQCcGTASTLEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:cd17550    1 ILIVDDEEDI----RESLSGIledEGYEV-DTAADGEEALKLI-KERRP-DLVLLDIWLPDMDGLELLKEIKEKYPDLPV 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQASRF 113
Cdd:cd17550   74 IMISGHGTIETAVKATKLGAYDFIEKPLSLDRL 106
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 4-107 2.88e-08

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 50.20  E-value: 2.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQ--CCGTASTLEKakeiiFNSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRA-GYEvrTTGNAATLWR-----WVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPII 74

                         90       100
                 ....*....|....*....|....*.
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKP 107
Cdd:cd19928   75 VMSAQNTLMTAVKAAERGAFEYLPKP 100
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-108 3.18e-08

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 50.30  E-value: 3.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   5 LIIDDDAMVAELNRRYVAQiPGF---QCCGTASTLEKAKEIIFnsdtpiDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKK-EGYtvdVCFDGEEGLEYALSGIY------DLIILDIMLPGMDGLEVLKSLREEGIETPVL 73

                         90       100
                 ....*....|....*....|....*...
gi 446533942  82 VIsSAADAATIK-DSLHYGVVDYLIKPF 108
Cdd:cd17625   74 LL-TALDAVEDRvKGLDLGADDYLPKPF 100
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-141 1.28e-07

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 50.10  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVA---QIPGFQCCGTAST---LEKAKEiifnsDTPiDLILLDIYMQKENGLDLLPVLHNARCK 77
Cdd:COG4566    2 VYIVDDDEAV----RDSLAfllESAGLRVETFASAeafLAALDP-----DRP-GCLLLDVRMPGMSGLELQEELAARGSP 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446533942  78 SDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALtgwrQKKMALEKHQYYDQAELDQL 141
Cdd:COG4566   72 LPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAV----RRALARDRARRAERARRAEL 131
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-108 2.22e-07

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 48.25  E-value: 2.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCCGtASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKA-GYAVDW-VRTGAEAEAAL--ASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLIL 76

                         90       100
                 ....*....|....*....|....*.
gi 446533942  84 sSAADAATIK-DSLHYGVVDYLIKPF 108
Cdd:cd17624   77 -TARDGVDDRvAGLDAGADDYLVKPF 101
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 2-117 6.31e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 46.95  E-value: 6.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIpGFQCCGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLpvlhnARCKSD-- 79
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKEL-GFNNVEEAEDGVDALEKLKAGG--FDFVITDWNMPNMDGLELL-----KTIRADga 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446533942  80 -----VIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd19923   73 lshlpVLMVTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKL 115
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 2-108 9.38e-07

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 46.06  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDTpiDLILLDIYMQKENGLDLLPVLHNARCKSD-- 79
Cdd:cd17561    2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEP--DVLLLDIIMPHLDGIGVLEKLRRMRLEKRpk 79

                         90       100
                 ....*....|....*....|....*....
gi 446533942  80 VIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17561   80 IIMLTAFGQEDITQRAVELGASYYILKPF 108
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-106 1.20e-06

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 46.19  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVAQI----PGFQCCGTASTLEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSD 79
Cdd:cd19931    1 VLLIDDHPLL----RKGIKQLieldPDFTVVGEASSGEEGIELA-ERLDP-DLILLDLNMKGMSGLDTLKALREEGVSAR 74

                         90       100
                 ....*....|....*....|....*..
gi 446533942  80 VIVISSAADAATIKDSLHYGVVDYLIK 106
Cdd:cd19931   75 IVILTVSDAEDDVVTALRAGADGYLLK 101
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-110 1.29e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 45.84  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQiPGFQCCGTASTlEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLhnaRCKSDV-- 80
Cdd:cd17619    2 HILIVEDEPVTRATLKSYFEQ-EGYDVSEAGDG-EEMRQIL--ARQDIDLVLLDINLPGKDGLSLTREL---REQSEVgi 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQA 110
Cdd:cd17619   75 ILVTGRDDEVDRIVGLEIGADDYVTKPFNP 104
PRK14084 PRK14084
DNA-binding response regulator;
2-124 1.40e-06

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 47.82  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARcKSDVI 81
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQ--YDIIFLDINLMDESGIELAAKIQKMK-EPPAI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446533942  82 VISSAADAATIKdSLHYGVVDYLIKPFQASRFEEALTGWRQKK 124
Cdd:PRK14084  78 IFATAHDQFAVK-AFELNATDYILKPFEQKRIEQAVNKVRATK 119
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 3-108 2.10e-06

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 45.32  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQiPGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLpvlhnARCKSD--- 79
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLER-AGFDVV-EAEDAESAVNLI--VEPRPDLILLDWMLPGGSGIQFI-----RRLKRDemt 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446533942  80 ----VIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17618   73 rdipIIMLTARGEEEDKVRGLEAGADDYITKPF 105
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-108 2.20e-06

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 45.45  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRyVAQIPGFQcCGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNArcKSDV-IV 82
Cdd:cd17627    1 ILVVDDDRAVRESLRR-SLRFEGYE-VETAVDGAEALRVI--SGNRPDAVVLDVMMPRLDGLEVCRRLRAA--GNDLpIL 74

                         90       100
                 ....*....|....*....|....*..
gi 446533942  83 ISSAADAATIK-DSLHYGVVDYLIKPF 108
Cdd:cd17627   75 VLTARDSVSDRvAGLDAGADDYLVKPF 101
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-108 2.26e-06

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 47.10  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVaQIPGFQCCgTASTLEKAKEIIfnsDTPIDLILLDIYMQKENGLDLLPVLHNARcKSDV 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELL-EMEGFNVI-VAHDGEQALDLL---DDSIDLLLLDVMMPKKNGIDTLKELRQTH-QTPV 74

                         90       100
                 ....*....|....*....|....*...
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:PRK10955  75 IMLTARGSELDRVLGLELGADDYLPKPF 102
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-108 4.33e-06

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 44.57  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   5 LIIDDDAMVAELnRRYVAQIPGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVIS 84
Cdd:cd19937    1 LVVDDEEDIVEL-LKYNLEKEGYEVV-TAYDGEEALKRA--KDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSIPIIM 76

                         90       100
                 ....*....|....*....|....*.
gi 446533942  85 SAADAATIKD--SLHYGVVDYLIKPF 108
Cdd:cd19937   77 LTAKGEEFDKvlGLELGADDYITKPF 102
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-108 4.62e-06

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 44.32  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQCcGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKS-EGFNV-YTTDLGEEGLDLGKLYD--YDIILLDLNLPDMSGYEVLRTLRLAKVKTPILIL 76

                         90       100
                 ....*....|....*....|....*
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17616   77 SGLADIEDKVKGLGFGADDYMTKPF 101
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 3-124 5.05e-06

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 46.79  E-value: 5.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQiPGFQCcgtaSTLEKAKEII--FNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:PRK10923   5 IVWVVDDDSSIRWVLERALAG-AGLTC----TTFENGNEVLeaLASKTP-DVLLSDIRMPGMDGLALLKQIKQRHPMLPV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQ----ASRFEEALTGWRQKK 124
Cdd:PRK10923  79 IIMTAHSDLDAAVSAYQQGAFDYLPKPFDideaVALVERAISHYQEQQ 126
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
2-117 5.15e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 46.95  E-value: 5.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDD----AMVAELNRRYvaqipGFQCCGTAS---TLEKAKEIIFnsdtpiDLILLDIYMQKENGLDLLPVLHNA 74
Cdd:PRK10365   6 IDILVVDDDishcTILQALLRGW-----GYNVALANSgrqALEQVREQVF------DLVLCDVRMAEMDGIATLKEIKAL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446533942  75 RCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:PRK10365  75 NPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATL 117
PRK10693 PRK10693
two-component system response regulator RssB;
51-167 5.65e-06

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 46.14  E-value: 5.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  51 DLILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQasrfeeALTGWRQKKMA-LEK 129
Cdd:PRK10693  19 DLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPVK------DLNRLREMVFAcLYP 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446533942 130 HQYYDQA-ELDQLIHGSSSNEQDP---RRLPKGLTPQTLRTL 167
Cdd:PRK10693  93 SMFNSRVeEEERLFRDWDALVDNPaaaAKLLKQLQPPVQQVI 134
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-59 5.73e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.56  E-value: 5.73e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446533942     2 INVLIIDDDAMVAELNRRYVAQiPGFQcCGTASTLEKAKEIIfnSDTPIDLILLDIYM 59
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEK-EGYE-VDEATDGEEALELL--KEEKPDLILLDIMM 54
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 4-108 6.87e-06

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 43.91  E-value: 6.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQccgtASTLEKAKEII-FNSDTPIDLILLDIYMQKENGLDLLPVLhnaRCKSDVIV 82
Cdd:cd19938    2 ILIVEDEPKLAQLLIDYLRA-AGYA----PTLLAHGDQVLpYVRHTPPDLILLDLMLPGTDGLTLCREI---RRFSDVPI 73

                         90       100
                 ....*....|....*....|....*...
gi 446533942  83 ISSAADAATIKD--SLHYGVVDYLIKPF 108
Cdd:cd19938   74 IMVTARVEEIDRllGLELGADDYICKPY 101
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 1-113 1.60e-05

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 44.80  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAqIPGFQCCGTASTLEKAKEIifnSDTPIDLILLDIYMQKENGLDllpVLHNARCKSDV 80
Cdd:PRK13856   1 MKHVLVIDDDVAMRHLIVEYLT-IHAFKVTAVADSQQFNRVL---ASETVDVVVVDLNLGREDGLE---IVRSLATKSDV 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446533942  81 IVISSAADAATIKD---SLHYGVVDYLIKPFQASRF 113
Cdd:PRK13856  74 PIIIISGDRLEEADkvvALELGATDFIAKPFGTREF 109
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-108 1.98e-05

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 42.58  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCcgtaSTLEKAKEiiFNSDTPIDL---ILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSV-GLAV----KTFTSASA--FLAAAPPDQpgcLVLDVRMPGMSGLELQDELLARGSNIPI 75

                         90       100
                 ....*....|....*....|....*...
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17537   76 IFITGHGDVPMAVEAMKAGAVDFLEKPF 103
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 4-109 2.98e-05

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 42.07  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELnRRYVAQIPGFQ--CCGTASTLEKAkeiiFNSDTPiDLILLDIYMQKENGLDLLPVLhnaRCKSDV- 80
Cdd:cd17626    3 ILVVDDDAALAEM-IGIVLRGEGFDpaFCGDGTQALAA----FREVRP-DLVLLDLMLPGIDGIEVCRQI---RAESGVp 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 446533942  81 -IVISSAADAATIKDSLHYGVVDYLIKPFQ 109
Cdd:cd17626   74 iVMLTAKSDTVDVVLGLESGADDYVAKPFK 103
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-117 3.76e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 41.69  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCcGTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVL--HNARCKSDVI 81
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKL-GYEV-DVAENGQEALELL--KEEPFDLVLMDLQMPVMDGLEATRRIreLEGGGRRTPI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446533942  82 V-ISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17546   77 IaLTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
ompR PRK09468
osmolarity response regulator; Provisional
 4-108 4.35e-05

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 43.42  E-value: 4.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQccgtASTLEKAKEI--IFNSDTpIDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTE-QGFQ----VRSAANAEQMdrLLTRES-FHLMVLDLMLPGEDGLSICRRLRSQNNPTPII 81

                         90       100
                 ....*....|....*....|....*..
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:PRK09468  82 MLTAKGEEVDRIVGLEIGADDYLPKPF 108
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 4-108 5.11e-05

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 41.49  E-value: 5.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQCcgtaSTLEKAKEII--FNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:cd19919    3 VWIVDDDSSIRWVLERALAG-AGLTV----TSFENAQEALaaLASSQP-DVLISDIRMPGMDGLALLAQIKQRHPDLPVI 76

                         90       100
                 ....*....|....*....|....*..
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd19919   77 IMTAHSDLDSAVSAYQGGAFEYLPKPF 103
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-106 5.32e-05

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 42.92  E-value: 5.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:PRK10403   9 VLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLA-NRLDP-DVILLDLNMKGMSGLDTLNALRRDGVTAQIIIL 86

                         90       100
                 ....*....|....*....|...
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIK 106
Cdd:PRK10403  87 TVSDASSDVFALIDAGADGYLLK 109
orf27 CHL00148
Ycf27; Reviewed
 4-115 5.70e-05

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 43.17  E-value: 5.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCCGTASTLEKAKeiIFNSDTPiDLILLDIYMQKENGLDllpVLHNARCKSDV--I 81
Cdd:CHL00148   9 ILVVDDEAYIRKILETRLSII-GYEVITASDGEEALK--LFRKEQP-DLVILDVMMPKLDGYG---VCQEIRKESDVpiI 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFQASRFEE 115
Cdd:CHL00148  82 MLTALGDVSDRITGLELGADDYVVKPFSPKELEA 115
PRK10643 PRK10643
two-component system response regulator PmrA;
4-108 5.88e-05

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 42.72  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAE-LNRryVAQIPGFqCCGTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARCKSDVIv 82
Cdd:PRK10643   3 ILIVEDDTLLLQgLIL--ALQTEGY-ACDCASTAREAEALLESGH--YSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVL- 76

                         90       100
                 ....*....|....*....|....*..
gi 446533942  83 ISSAADAATIK-DSLHYGVVDYLIKPF 108
Cdd:PRK10643  77 ILTARDTLEDRvAGLDVGADDYLVKPF 103
PRK11697 PRK11697
two-component system response regulator BtsR;
1-122 6.02e-05

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 42.91  E-value: 6.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTAS-TLEKAKEIifNSDTPiDLILLDIYMQKENGLDLLPVL---HNARc 76
Cdd:PRK11697   1 MIKVLIVDDEPLAREELRELLQEEGDIEIVGECSnAIEAIGAI--HRLKP-DVVFLDIQMPRISGLELVGMLdpeHMPY- 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446533942  77 ksdvIVISSAADAATIKdSLHYGVVDYLIKPFQASRFEEALTGWRQ 122
Cdd:PRK11697  77 ----IVFVTAFDEYAIK-AFEEHAFDYLLKPIDPARLAKTLARLRQ 117
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 4-109 6.14e-05

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 41.20  E-value: 6.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQiPGFQCcGTASTLEKAKEIIfnSDTPIDLILLDIYMQkenGLDLLPVLHNARCKSDV--I 81
Cdd:cd19939    2 ILIVEDELELARLTRDYLIK-AGLEV-SVFTDGQRAVRRI--IDEQPSLVVLDIMLP---GMDGLTVCREVREHSHVpiL 74

                         90       100
                 ....*....|....*....|....*...
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFQ 109
Cdd:cd19939   75 MLTARTEEMDRVLGLEMGADDYLCKPFS 102
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-117 6.39e-05

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 41.10  E-value: 6.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnRRYVAQI----PGFQCCGTASTLEKAKEIIfNSDTPiDLILLDIYMQKENGLDLLPVLHNARCKSD 79
Cdd:cd19930    1 VLIAEDQEMV----RGALAALleleDDLEVVAQASNGQEALRLV-LKHSP-DVAILDIEMPGRTGLEVAAELREELPDTK 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446533942  80 VIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd19930   75 VLIVTTFGRPGYFRRALAAGVDGYVLKDRPIEELADAI 112
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 2-117 7.08e-05

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 40.98  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCgTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARCKSDVI 81
Cdd:cd17593    1 MKVLICDDSSMARKQLARALPADWDVEIT-FAENGEEALEILREGR--IDVLFLDLTMPVMDGYEVLEALPVEQLETKVI 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:cd17593   78 VVSGDVQPEAKERVLELGALAFLKKPFDPEKLAQLL 113
fixJ PRK09390
response regulator FixJ; Provisional
 53-117 9.58e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 41.91  E-value: 9.58e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446533942  53 ILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEAL 117
Cdd:PRK09390  51 VVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAI 115
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 2-108 1.04e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 40.58  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDA----MVAELNRRYVAQIpgFQccgtASTLEKAKEIIfNSDTPIDLILLDIYMQKENGLDLLPVLHNARCK 77
Cdd:cd17544    1 IKVLVVDDSAtsrnHLRALLRRHNFQV--LE----AANGQEALEVL-EQHPDIKLVITDYNMPEMDGFELVREIRKKYSR 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446533942  78 SD--VIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17544   74 DQlaIIGISASGDNALSARFIKAGANDFLTKPF 106
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 3-106 1.22e-04

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 40.24  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQIPGFQCcGTASTLEKAKEIIfNSDTPIDLILLDIYM-QKENG--LDLlpVL-HNARCks 78
Cdd:cd19921    1 KVLIVEDSKTFSKVLKHLIAQELGLEV-DVAETLAEAKALL-EEGDDYFAALVDLNLpDAPNGeaVDL--VLeKGIPV-- 74

                         90       100
                 ....*....|....*....|....*...
gi 446533942  79 dvIVISSAADAATIKDSLHYGVVDYLIK 106
Cdd:cd19921   75 --IVLTGSFDEDKRETLLSKGVVDYVLK 100
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 3-95 1.32e-04

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 40.28  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRR------YVAQipgfqccgTASTLEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLHNARC 76
Cdd:cd17554    2 KILVVDDEENIRELYKEeledegYEVV--------TAGNGEEALEKLESED--PDLVILDIKMPGMDGLETLRKIREKKP 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 446533942  77 KSDVIVISS-----------AADAATIKDS 95
Cdd:cd17554   72 DLPVIICTAyseyksdfsswAADAYVVKSS 101
PRK10766 PRK10766
two-component system response regulator TorR;
3-109 1.35e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 41.95  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELNRRYVAQiPGFQCCGTASTlEKAKEIIFNSDtpIDLILLDIYMQKENGLDLLPVLhnaRCKSDV-- 80
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQ-EGYTVSEAASG-AGMREIMQNQH--VDLILLDINLPGEDGLMLTREL---RSRSTVgi 76

                         90       100
                 ....*....|....*....|....*....
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQ 109
Cdd:PRK10766  77 ILVTGRTDSIDRIVGLEMGADDYVTKPLE 105
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-117 1.57e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 39.96  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAmvaELNRRYVAQI--PGFQCcgtaSTLEKAKEIIFNSDT-PIDLILLDIYMQKENGLDLLPVLHNARCKSDV 80
Cdd:cd19934    1 LLLVEDDA---LLAAQLKEQLsdAGYVV----DVAEDGEEALFQGEEePYDLVVLDLGLPGMDGLSVLRRWRSEGRATPV 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446533942  81 IVISSAADAATIKDSLHYGVVDYLIKPFQasrFEEAL 117
Cdd:cd19934   74 LILTARDSWQDKVEGLDAGADDYLTKPFH---IEELL 107
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-108 1.71e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 39.64  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCCGTASTLEKAKeiIFNSDTPIDLILLDIYMQ-KENGLDLLPVLHNARCKSDVIV 82
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDL-GYTVLEAASGDEALD--LLESGPDIDLLVTDVIMPgGMNGSQLAEEARRRRPDLKVLL 77

                         90       100
                 ....*....|....*....|....*.
gi 446533942  83 ISSAADAATIKDSLHYGvVDYLIKPF 108
Cdd:cd18161   78 TSGYAENAIEGGDLAPG-VDVLSKPF 102
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-107 3.02e-04

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 39.07  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRyVAQIPGFQCCgTASTLEKAKeIIFNSDTPiDLILLDIYMQKENGLDllpVLHNARCKSDV--I 81
Cdd:cd17620    1 ILVIEDEPQIRRFLRT-ALEAHGYRVF-EAETGQEGL-LEAATRKP-DLIILDLGLPDMDGLE---VIRRLREWSAVpvI 73

                         90       100
                 ....*....|....*....|....*.
gi 446533942  82 VISSAADAATIKDSLHYGVVDYLIKP 107
Cdd:cd17620   74 VLSARDEESDKIAALDAGADDYLTKP 99
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 2-106 3.07e-04

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 39.70  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPG--FQCCGtastlEKAKEIIFNSDTPIDLILLDIYMQKENGLDLLPVL--HNARCK 77
Cdd:cd17575    1 IMVLLVDDQAIIGEAVRRALADEEDidFHYCS-----DPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFraNPATRD 75

                         90       100
                 ....*....|....*....|....*....
gi 446533942  78 SDVIVISSAADAATIKDSLHYGVVDYLIK 106
Cdd:cd17575   76 IPIIVLSTKEEPEVKSEAFALGANDYLVK 104
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 4-111 4.15e-04

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 38.93  E-value: 4.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaELNRRYVAQIPGFQCCGTAS----TLEKAKEIifnsdTPiDLILLDIYMQKENGLDLLPVLHNARCkSD 79
Cdd:cd19932    3 VLIAEDEALI-RMDLREMLEEAGYEVVGEASdgeeAVELAKKH-----KP-DLVIMDVKMPRLDGIEAAKIITSENI-AP 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446533942  80 VIVISSAADAATIKDSLHYGVVDYLIKPFQAS 111
Cdd:cd19932   75 IVLLTAYSQQDLVERAKEAGAMAYLVKPFSES 106
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 49-108 5.41e-04

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 38.26  E-value: 5.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446533942  49 PIDLILLDIYMQKENGLDLLpvlhnARCKSD-------VIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd19920   42 PPDLILLDVMMPGMDGFEVC-----RRLKADpatrhipVIFLTALTDTEDKVKGFELGAVDYITKPF 103
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 4-108 7.10e-04

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 37.86  E-value: 7.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCCGTAS---TLEKAKEiifnsdTPIDLILLDIYMQKENGLDllpVLHnaRCKSD- 79
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAE-GYEVLTADSgqeALALAEE------ELPDLILLDVMMPGMDGFE---VCR--RLKEDp 69

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446533942  80 ------VIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17538   70 etrhipVIMITALDDREDRIRGLEAGADDFLSKPI 104
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 4-107 8.40e-04

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 37.90  E-value: 8.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVAELNRRYVAQIpGFQCCgTASTLEKAKEIIfnSDTPIDLILLDIYMQKENGLDLLPVLHNARCKSDVIVI 83
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRM-GLDVR-SARNVKEARELL--ASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVI 76

                         90       100
                 ....*....|....*....|....
gi 446533942  84 SSAADAATIKDSLHYGVVDYLIKP 107
Cdd:cd19926   77 TAYGSLDTAIEALKAGAFDFLTKP 100
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 51-108 1.29e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 38.75  E-value: 1.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446533942  51 DLILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:PRK09836  46 DLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPF 103
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 50-107 2.18e-03

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 36.61  E-value: 2.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  50 IDLILLDIYMQKENGLDLLPVL--HNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKP 107
Cdd:cd17582   45 IDLILTEVDLPVSSGFKLLSYImrHKICKNIPVIMMSSQDSVGVVFKCLSKGAADYLVKP 104
PRK15369 PRK15369
two component system response regulator;
2-169 3.04e-03

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 37.75  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   2 INVLIIDDDAMVAELNRRYVAQIPGFQCCGTAST-LEkakeiIFNS--DTPIDLILLDIYMQKENGLDLLPVLHNARCKS 78
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNgLE-----VYNAcrQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  79 DVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALtgwrqkKMALEKHQYYDQAELDQLIHGSSSNEQDPrrlPKG 158
Cdd:PRK15369  79 NILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAI------QTVAVGKRYIDPALNREAILALLNADDTN---PPL 149

                        170
                 ....*....|....
gi 446533942 159 LTP---QTLRTLCQ 169
Cdd:PRK15369 150 LTPrerQILKLITE 163
PRK10610 PRK10610
chemotaxis protein CheY;
51-118 3.06e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 36.88  E-value: 3.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  51 DLILLDIYMQKENGLDLLPVLH--NARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALT 118
Cdd:PRK10610  52 GFVISDWNMPNMDGLELLKTIRadGAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLN 121
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-167 3.36e-03

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 37.48  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   1 MINVLIIDDDAMVaelnRRYVAqipgfqccgtaSTLEKAKEIIFNSDT------------PiDLILLDIYMQKENGLDLL 68
Cdd:PRK10529   1 MTNVLIVEDEQAI----RRFLR-----------TALEGDGMRVFEAETlqrglleaatrkP-DLIILDLGLPDGDGIEFI 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942  69 PVLHNARCKSdVIVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALtgwrqkKMALEKHQYYDQAelDQLIHGSS-S 147
Cdd:PRK10529  65 RDLRQWSAIP-VIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARL------RVALRRHSATPAP--DPLVKFSDvT 135

                        170       180
                 ....*....|....*....|....*
gi 446533942 148 NEQDPRRLPKG-----LTPQTLRTL 167
Cdd:PRK10529 136 VDLAARVIHRGeeevhLTPIEFRLL 160
PRK09483 PRK09483
response regulator; Provisional
 1-66 3.98e-03

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 37.39  E-value: 3.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446533942   1 MINVLIIDDDAMVAELNRRYVAQIPGFQCCGTASTLEKAkeIIFNSDTPIDLILLDIYMQKENGLD 66
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDA--VKWCRTNAVDVVLMDMNMPGIGGLE 64
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 51-108 4.20e-03

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 35.87  E-value: 4.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446533942  51 DLILLDIYMQKENGLDLLPVLHNARCKSDVIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17573   44 DLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNPKTEQEIEAFKEGADDYIAKPF 101
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 3-113 4.29e-03

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 35.98  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   3 NVLIIDDDAMVAELnRRYVAQIPGFQCCgTASTLEKAKEIIFNSdTPiDLILLDIYMQKENGLDLLPVLHNARCKSDVIV 82
Cdd:cd17548    1 KILIVEDNPLNMKL-ARDLLESAGYEVL-EAADGEEALEIARKE-KP-DLILMDIQLPGMDGLEATRLLKEDPATRDIPV 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446533942  83 ISSAA-----DAATIKDSlhyGVVDYLIKPFQASRF 113
Cdd:cd17548   77 IALTAyamkgDREKILEA---GCDGYISKPIDTREF 109
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 4-108 5.40e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 35.99  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533942   4 VLIIDDDAMVaelnrRYVAQI-----PGFQCCGTAS---TLEKAKeiifnSDTPiDLILLDIYMQKENGLDLLPVLH-NA 74
Cdd:cd17552    4 ILVIDDEEDI-----REVVQAcleklAGWEVLTASSgqeGLEKAA-----TEQP-DAILLDVMMPDMDGLATLKKLQaNP 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446533942  75 RCKS-DVIVISSAADAATIKDSLHYGVVDYLIKPF 108
Cdd:cd17552   73 ETQSiPVILLTAKAQPSDRQRFASLGVAGVIAKPF 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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