|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-450 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 558.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 2 INVTLKQIQSWIPCEIEDQfLNQEINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDenvsG 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGD-PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPAD----L 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 82 PIIWVEDTLTALQQLAQAYLRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEIS 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 162 ILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVeNAK 241
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERA-KAR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 242 CISIGVATDNALVCCVDDRDTTGISFTIN---NKEHYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMR 318
Cdd:COG0770 235 VLTFGLSEDADVRAEDIELDEDGTRFTLHtpgGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGR 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 319 MEQHTLENDITVINDAYNASPTSMRAAIDTLSTLT--GRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEA 396
Cdd:COG0770 315 LEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELA 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 446534110 397 KYIYDSGqqHVEKAQHFNSKDDMIGVLTSDLKAHDRVLVKGSRGMKLEEVVNAL 450
Cdd:COG0770 395 RAIAEAA--GGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
31-450 |
1.37e-157 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 452.11 E-value: 1.37e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 31 IDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVsgPIIWVEDTLTALQQLAQAYLRHVNPKVIA 110
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNGL--PQILVDDTLEALQALARAKRAKFSGKVIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 111 VTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQPDIAVITNI 190
Cdd:TIGR01143 79 ITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 191 GESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGvATDNALVC---CVDDRDTTGISF 267
Cdd:TIGR01143 159 GPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFG-FEGGDFVAkdiSYSALGSTSFTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 268 TINNKE-HYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEqHTLENDITVINDAYNASPTSMRAAI 346
Cdd:TIGR01143 238 VAPGGEfEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 347 DTLSTLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQqhvEKAQHFNSKDDMIGVLTSD 426
Cdd:TIGR01143 317 DALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFG---KQGKHFADKDELLAFLKTL 393
|
410 420
....*....|....*....|....
gi 446534110 427 LKAHDRVLVKGSRGMKLEEVVNAL 450
Cdd:TIGR01143 394 VRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
26-451 |
1.85e-122 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 379.05 E-value: 1.85e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 26 INGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPideNVSGPIIWVEDTLTALQQLAQAYLRHVN 105
Cdd:PRK11929 526 AGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVA---DVDLPQIVVDDTRAALGRLATAWRARFS 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 106 PKVIAVTGSNGKTTTKDMIESVLHT---EFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQP 182
Cdd:PRK11929 603 LPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAP 682
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 183 DIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGV--ATDNALVCCVDDR 260
Cdd:PRK11929 683 TVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLqpGADVYAEKIAKDI 762
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 261 DT---TGISFTIN-NKEHYD--LPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEQHTLENDITVINDA 334
Cdd:PRK11929 763 SVgeaGGTRCQVVtPAGSAEvyLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDT 842
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 335 YNASPTSMRAAIDTLSTL-TGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQQHveKAQHF 413
Cdd:PRK11929 843 YNANPDSMRAAIDVLAELpNGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFGAG--ARGVC 920
|
410 420 430
....*....|....*....|....*....|....*...
gi 446534110 414 NSKDDMIGVLTSDLKAHDRVLVKGSRGMKLEEVVNALI 451
Cdd:PRK11929 921 ASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-295 |
8.81e-45 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 154.77 E-value: 8.81e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 111 VTGSNGKTTTKDMIESVLHTEFKVKKTQG--------NYNNEIGLPLTILEL-DNDTEISILEMGMSGFHEiEFLSNLAQ 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 182 PDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKC--ISIGVATDNALVCC--- 256
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGVrvITYGIEGEADLRAAnie 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446534110 257 VDDRDTTGISFTINNKEH-YDLPILGKHNMKNATIAIAVG 295
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELeIEIPLLGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
107-361 |
8.41e-05 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 44.62 E-value: 8.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 107 KVIAVTGSNGKTTTKDMIESVLHTEFKVKKT-QGNYNNEIGL--------PLTILE-LDNDTEISILEMGMSGFhEIEfL 176
Cdd:NF033197 93 KFIEITGVKGKTTTAELLAHILSDEYVLLHTsRGTERYPEGElsnkgsitPASILNaLELAEEIGIDDYGFLIF-EVS-L 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 177 SNLAQPDIAVITNIGESHmqdlgsreGIAK-------AKSEIT-------IGLKDNGTFIYDGDEPLLKPHVKEVENAKC 242
Cdd:NF033197 171 GGTGAGDVGIITNILEDY--------PIAGgkrsasaAKLQSLknakvgsINVADLGIYINGKNKLVITVAGVEILSKYP 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 243 IsigvatdnalvccVDDRDTTGISFtiNNKehydlpILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEQH 322
Cdd:NF033197 243 L-------------RFKYGNTEFEF--NPL------LFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPGRMAVK 301
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446534110 323 TLENdITVINdayNASP-TSMRA---AIDTLSTLTGRRILILG 361
Cdd:NF033197 302 KEGG-VVIVD---NINPgLNVKAieyALDDALELLGDGTLVIG 340
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-450 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 558.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 2 INVTLKQIQSWIPCEIEDQfLNQEINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDenvsG 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGD-PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPAD----L 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 82 PIIWVEDTLTALQQLAQAYLRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEIS 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 162 ILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVeNAK 241
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERA-KAR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 242 CISIGVATDNALVCCVDDRDTTGISFTIN---NKEHYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMR 318
Cdd:COG0770 235 VLTFGLSEDADVRAEDIELDEDGTRFTLHtpgGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGR 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 319 MEQHTLENDITVINDAYNASPTSMRAAIDTLSTLT--GRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEA 396
Cdd:COG0770 315 LEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELA 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 446534110 397 KYIYDSGqqHVEKAQHFNSKDDMIGVLTSDLKAHDRVLVKGSRGMKLEEVVNAL 450
Cdd:COG0770 395 RAIAEAA--GGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
31-450 |
1.37e-157 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 452.11 E-value: 1.37e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 31 IDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVsgPIIWVEDTLTALQQLAQAYLRHVNPKVIA 110
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNGL--PQILVDDTLEALQALARAKRAKFSGKVIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 111 VTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQPDIAVITNI 190
Cdd:TIGR01143 79 ITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 191 GESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGvATDNALVC---CVDDRDTTGISF 267
Cdd:TIGR01143 159 GPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFG-FEGGDFVAkdiSYSALGSTSFTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 268 TINNKE-HYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEqHTLENDITVINDAYNASPTSMRAAI 346
Cdd:TIGR01143 238 VAPGGEfEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 347 DTLSTLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQqhvEKAQHFNSKDDMIGVLTSD 426
Cdd:TIGR01143 317 DALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFG---KQGKHFADKDELLAFLKTL 393
|
410 420
....*....|....*....|....
gi 446534110 427 LKAHDRVLVKGSRGMKLEEVVNAL 450
Cdd:TIGR01143 394 VRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
26-451 |
1.85e-122 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 379.05 E-value: 1.85e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 26 INGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPideNVSGPIIWVEDTLTALQQLAQAYLRHVN 105
Cdd:PRK11929 526 AGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVA---DVDLPQIVVDDTRAALGRLATAWRARFS 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 106 PKVIAVTGSNGKTTTKDMIESVLHT---EFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQP 182
Cdd:PRK11929 603 LPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAP 682
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 183 DIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGV--ATDNALVCCVDDR 260
Cdd:PRK11929 683 TVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLqpGADVYAEKIAKDI 762
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 261 DT---TGISFTIN-NKEHYD--LPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEQHTLENDITVINDA 334
Cdd:PRK11929 763 SVgeaGGTRCQVVtPAGSAEvyLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDT 842
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 335 YNASPTSMRAAIDTLSTL-TGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQQHveKAQHF 413
Cdd:PRK11929 843 YNANPDSMRAAIDVLAELpNGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFGAG--ARGVC 920
|
410 420 430
....*....|....*....|....*....|....*...
gi 446534110 414 NSKDDMIGVLTSDLKAHDRVLVKGSRGMKLEEVVNALI 451
Cdd:PRK11929 921 ASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-450 |
9.42e-82 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 259.58 E-value: 9.42e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 1 MINVTLKQIQSWIPCEIEDQflNQEINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDenvs 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGA--DITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDID---- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 81 GPIIWVEDTLTALQQLAqAYLR-HVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTE 159
Cdd:PRK10773 75 LPQLVVKDTRLAFGQLA-AWVRqQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 160 ISILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLkPHVKEVEN 239
Cdd:PRK10773 154 YAVIELGANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDW-LNWQSVIG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 240 AKCI---SIGvATDNALVCCVDDRDTT-GISFTINN---KEHYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNV 312
Cdd:PRK10773 233 SKTVwrfSPN-AANSVDFTATNIHVTShGTEFTLHTptgSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 313 SLTGMRMEQHTLENDITVINDAYNASPTSMRAAIDTLSTLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTF 392
Cdd:PRK10773 312 KAVPGRLFPIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSV 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446534110 393 GNEAKYIYD-SGqqhveKAQHFNSKDDMIGVLTSDLKAHD--RVLVKGSRGMKLEEVVNAL 450
Cdd:PRK10773 392 GKLSHAISEaSG-----VGEHFADKTALIARLKALLAEHQviTILVKGSRSAAMEEVVRAL 447
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
22-450 |
8.26e-65 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 216.18 E-value: 8.26e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 22 LNQEINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVSGPIIWVEDTLTALQQLAQAYL 101
Cdd:PRK14093 24 LPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKFAADAPLLVVDDVLAALRDLGRAAR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 102 RHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQ 181
Cdd:PRK14093 104 ARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 182 PDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPL---LKPHVKEVENAKCISIGV--ATDNALVCC 256
Cdd:PRK14093 184 PHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQfdrLAASARAAGIARIVSFGAdeKADARLLDV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 257 VDDRDTTGISFTINNKE-HYDLPILGKHNMKNATIAIA----VGHELGLTYNTIYQnLKNVSLTGMRmeqHTLE---NDI 328
Cdd:PRK14093 264 ALHADCSAVHADILGHDvTYKLGMPGRHIAMNSLAVLAaaelAGADLALAALALSQ-VQPAAGRGVR---HTLEvggGEA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 329 TVINDAYNASPTSMRAAIDTLSTLT----GRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYD--- 401
Cdd:PRK14093 340 TLIDESYNANPASMAAALGVLGRAPvgpqGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVFCCGPLMRNLWDals 419
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 446534110 402 SGQQ--HVEKAQHFNSKddmigvLTSDLKAHDRVLVKGSRGMKLEEVVNAL 450
Cdd:PRK14093 420 SGKRggYAEDAAALESQ------VVAAIRAGDVIMVKGSLGSRMKTIVTAL 464
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
2-450 |
8.47e-60 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 209.43 E-value: 8.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 2 INVTLKQIQSWIPCEIEDQFlNQEINGVTIDSRAIS--KNMLFIPFEGENVDGHRFVSKALQDGAgAAFYQKGTPIDENV 79
Cdd:PRK11930 1 MSYTLESISGILGAEGLGDK-DAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGV-RNFVVSEEKHPEES 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 80 SGPIIW--VEDTLTALQQLAQAYLRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDND 157
Cdd:PRK11930 79 YPDANFlkVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 158 TEISILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEItigLKDNGTFIYDGD-EPLLKPHVKE 236
Cdd:PRK11930 159 HELGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKL---FKDCDVIIYNGDnELISSCITKS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 237 VENAKCISIGVATDNA--LVCCVD-DRDTTGISFTINNKE-HYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNV 312
Cdd:PRK11930 236 NLTLKLISWSRKDPEAplYIPFVEkKEDHTVISYTYKGEDfHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 313 SLTGMRMEQHTLENDITVINDAYNASPTSMRAAIDTLS--TLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLY 390
Cdd:PRK11930 316 EPVAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNrrSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLI 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446534110 391 TFGNE---AKYIYDSGqqhveKAQHFNSKDDMIGVLTSDLKAHDRVLVKGSRGMKLEEVVNAL 450
Cdd:PRK11930 396 GIGEEissEASKFEGT-----EKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-295 |
8.81e-45 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 154.77 E-value: 8.81e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 111 VTGSNGKTTTKDMIESVLHTEFKVKKTQG--------NYNNEIGLPLTILEL-DNDTEISILEMGMSGFHEiEFLSNLAQ 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 182 PDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKC--ISIGVATDNALVCC--- 256
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGVrvITYGIEGEADLRAAnie 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446534110 257 VDDRDTTGISFTINNKEH-YDLPILGKHNMKNATIAIAVG 295
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELeIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
28-361 |
2.53e-34 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 133.28 E-value: 2.53e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 28 GVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQK-GTPIDENVsgPIIWVEDTLTALQQLAQAYLRHvnP 106
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEApGALLAAGV--PVIVVPDPRAALALLAAAFYGH--P 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 107 ----KVIAVTGSNGKTTTKDMIESVLhtefkvkkTQGNYN------NEIGLPLTILELDNDT------------------ 158
Cdd:COG0769 77 sqklKLIGVTGTNGKTTTTYLLAQIL--------RALGKKtgligtVGNGIGGELIPSSLTTpealdlqrllaemvdagv 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 159 -----EIS--ILEMGMsgFHEIEFlsnlaqpDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLK 231
Cdd:COG0769 149 thvvmEVSshALDQGR--VDGVRF-------DVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 232 PHVKEVeNAKCISIGVATDNALVCCVDDRDTTGISFTINNKE---HYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQN 308
Cdd:COG0769 220 RLAAAA-PARVITYGLKADADLRATDIELSADGTRFTLVTPGgevEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAA 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446534110 309 LKNVS-LTGmRMEQHTLENDITVINDaYNASPTSMRAAIDTLSTLTGRR-ILILG 361
Cdd:COG0769 299 LEKLKgVPG-RMERVDGGQGPTVIVD-YAHTPDALENVLEALRPHTKGRlIVVFG 351
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
102-361 |
7.21e-33 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 129.05 E-value: 7.21e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 102 RHVNPKVIAVTGSNGKTTTKDMIESVLHTEFkvKKTQ--GNynneIGLP-LTILELDNDTEISILEmgMSGFhEIEFLSN 178
Cdd:COG0771 101 RLSPAPIIAITGTNGKTTTTTLIGHILKAAG--LRVAvgGN----IGTPlLDLLLEPEPPDVYVLE--LSSF-QLETTPS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 179 LAqPDIAVITNIGESHMqDL-GSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVeNAKCISIGVATDNALVCCV 257
Cdd:COG0771 172 LR-PDVAVILNITPDHL-DRhGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEA-KARVVPFSLKEPLEGGAGL 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 258 DDRDttgISFTINNKEHY---DLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKnvSLTGM--RMEQHTLENDITVIN 332
Cdd:COG0771 249 EDGK---LVDRASGEELLpvdDLRLPGRHNLENALAALAAARALGVPPEAIREALR--SFKGLphRLEFVAEINGVRFIN 323
|
250 260 270
....*....|....*....|....*....|.
gi 446534110 333 D--AYNasPTSMRAAidtLSTLTGRRILILG 361
Cdd:COG0771 324 DskATN--PDATLAA---LESFDGPVVLIAG 349
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
26-360 |
1.98e-28 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 118.65 E-value: 1.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 26 INGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFY-QKGTPIDENVSGPIIWVEDTLTALQQLAQAYLRHV 104
Cdd:PRK11929 29 TADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVeAEGEDQVAAADALVLPVADLRKALGELAARWYGRP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 105 NPK--VIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNN-----EIGLPLTILE-----------LDNDTEISILEMG 166
Cdd:PRK11929 109 SEQlsLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGArldgrLIPGSLTTPDaiilhrilarmRAAGADAVAMEAS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 167 MSGFhEIEFLSNLAQpDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLkPHVKEVENaKCISIG 246
Cdd:PRK11929 189 SHGL-EQGRLDGLRI-AVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAA-ARLLAALP-RGLKVG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 247 VATDN--ALVCCVDDRDT-TGISFTI-NNKEHY--DLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRME 320
Cdd:PRK11929 265 YSPQNagADVQARDLRATaHGQVFTLaTPDGSYqlVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRME 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446534110 321 ---QHTLENDITVINDaYNASPTSMRAAIDTLSTLT---GRRILIL 360
Cdd:PRK11929 345 rvgPTAGAQGPLVVVD-YAHTPDALAKALTALRPVAqarNGRLVCV 389
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
19-361 |
1.84e-27 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 114.07 E-value: 1.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 19 DQFLNQEINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVsgPIIWVEDTLTALQQLAQ 98
Cdd:PRK00139 8 DLLAPVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAGTGV--PVIIVPDLRKALALLAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 99 AYLRHvnP----KVIAVTGSNGKTTTKDMIESVLH-----------TEFKVkktqGNYNNEIGL----PLTILELDNDte 159
Cdd:PRK00139 86 AFYGH--PsdklKLIGVTGTNGKTTTAYLLAQILRllgektaligtLGNGI----GGELIPSGLttpdALDLQRLLAE-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 160 isILEMGMSGF--------------HEIEFlsnlaqpDIAVITNIGESHMQDLGSREGIAKAKSEItigLKDNGTF-IYD 224
Cdd:PRK00139 158 --LVDAGVTYAamevsshaldqgrvDGLKF-------DVAVFTNLSRDHLDYHGTMEDYLAAKARL---FSELGLAaVIN 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 225 GDEPllkphVKEVENAKCISIGVATDNALVCCVDDR-DTTGISFTINNkeHYDLPILGKHNMKNATIAIAVGHELGLTYN 303
Cdd:PRK00139 226 ADDE-----VGRRLLALPDAYAVSMAGADLRATDVEyTDSGQTFTLVT--EVESPLIGRFNVSNLLAALAALLALGVPLE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446534110 304 TIYQNLKNvsLTGM--RMEQHTLENDITVIND-AYNasPTSMRAAIDTLSTLT-GRRILILG 361
Cdd:PRK00139 299 DALAALAK--LQGVpgRMERVDAGQGPLVIVDyAHT--PDALEKVLEALRPHAkGRLICVFG 356
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
107-435 |
1.06e-24 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 105.92 E-value: 1.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 107 KVIAVTGSNGKTTTKDMIESVLHtefkvkktqgnynnEIGLPLTIL---ELDN--------DTEISIlemgmsgfheIE- 174
Cdd:COG0773 105 RSIAVAGTHGKTTTTSMLAHILE--------------EAGLDPTFLiggILNNfgtnarlgDGDYFV----------AEa 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 175 ------FLsNLaQPDIAVITNIGESHMqDL-GSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKpHVKEVENAKCISIGV 247
Cdd:COG0773 161 desdgsFL-HY-SPDIAVVTNIEADHL-DIyGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLR-ELLPRCGRPVITYGF 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 248 AtDNALVCCVDDR-DTTGISFTI--NNKE--HYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEQH 322
Cdd:COG0773 237 S-EDADYRAENIRiDGGGSTFDVlrRGEElgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELK 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 323 TLENDITVINDaYNASPTSMRAAIDTL-STLTGRRILIlgdVLELGENS--KEMhigvgnyLEE-----KHIDVLYTFgn 394
Cdd:COG0773 316 GEVGGVTVIDD-YAHHPTEIAATLAAArEKYPDRRLVA---VFQPHRYSrtRDF-------LDEfaealSLADEVILL-- 382
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446534110 395 eakYIYDSG----------------QQHVEKAQHFNSKDDMIGVLTSDLKAHDRVLV 435
Cdd:COG0773 383 ---DIYAARekpipgvssedlaeaiRKRGKDVVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
23-360 |
2.00e-23 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 102.39 E-value: 2.00e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 23 NQEINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQkgTPIDENVSG-PIIWVEDTLTALQQLAQAYL 101
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVE--RDVDFYVAPvPVIIVPDLRHALSSLAAAFY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 102 RHV--NPKVIAVTGSNGKTTTKDMIESVLhtEFKVKKTQ--GNYNNEIGLPLTILELDNDTEISILEMgMSGFHE----- 172
Cdd:TIGR01085 79 GHPskKLKVIGVTGTNGKTTTTSLIAQLL--RLLGKKTGliGTIGYRLGGNDLIKNPAALTTPEALTL-QSTLAEmveag 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 173 -----IEFLSN-LAQP-------DIAVITNIGESHMQDLGSREGIAKAKSEI--TIGLKDNGTFIYD---GDEpLLK--P 232
Cdd:TIGR01085 156 aqyavMEVSSHaLAQGrvrgvrfDAAVFTNLSRDHLDFHGTMENYFAAKASLftELGLKRFAVINLDdeyGAQ-FVKrlP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 233 HVKEVENAKCISIGVATDNALVccVDDRDTTGISFTI---NNKEHYDLPILGKHNMKNATIAIAVGHELG-LTYNTIYQN 308
Cdd:TIGR01085 235 KDITVSAITQPADGRAQDIKIT--DSGYSFEGQQFTFetpAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446534110 309 LKNVSLTGMRMEQHTLENDITVINDaYNASPTSMRAAIDTLSTLTGRRILIL 360
Cdd:TIGR01085 313 LEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVV 363
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
101-434 |
3.62e-23 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 101.26 E-value: 3.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 101 LRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNynneIGLPLTILELDNDTEISILEmgMSGFhEIEFLSNLA 180
Cdd:TIGR01087 97 LRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLE--LSSF-QLETTESLR 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 181 qPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHvKEVENAKCISIGV--ATDNALVccvd 258
Cdd:TIGR01087 170 -PEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARL-AQKSKAQVIWFSVekDAERGLC---- 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 259 dRDTTGISFTINNKEhydLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKnvSLTGM--RMEQHTLENDITVINDAYN 336
Cdd:TIGR01087 244 -IRDGGLYLKPNDLE---GSLLGLHNAENILAAIALAKSLGLNLEAILEALR--SFKGLphRLEYVGQKNGVHFYNDSKA 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 337 ASPTSMRAAidtLSTLTGRRILILGdvlelGENSKEMHIGVGNYLEEKHIDVlYTFGNEAKYIYDSGQQHVEKAQHFNSK 416
Cdd:TIGR01087 318 TNVHATLAA---LSAFDNPVILIVG-----GDDKGADFSPLAPAAAGKVKAV-LAIGEDAAKIAPLLKEAGLSVYLVESL 388
|
330
....*....|....*...
gi 446534110 417 DDMIGVLTSDLKAHDRVL 434
Cdd:TIGR01087 389 EEAVQAAREVASPGDVVL 406
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
103-361 |
6.21e-15 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 76.30 E-value: 6.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 103 HVNPKVIAVTGSNGKTTTKDMIESVL-------------H--------------------TEF--KVKKtqgnYNNEIGL 147
Cdd:COG0285 37 QRKLPVIHVAGTNGKGSTAAMLESILraagyrvglytspHlvrfneriringepisdeelVEAleEVEP----AVEEVDA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 148 -PLTILEL----------DNDTEISILEMGMSGfheiEFLS-NLAQPDIAVITNIGESHMQDLGS-REGIAKAKSEItig 214
Cdd:COG0285 113 gPPTFFEVttaaaflyfaEAPVDVAVLEVGLGG----RLDAtNVIDPLVSVITSIGLDHTDFLGDtLEEIAREKAGI--- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 215 LKDNGT-FIYDGDEPLLKP---HVKEVeNAKCISIGVAtdnalvCCVDDRDTTGISFTINNKEHYDLPI--LGKHNMKNA 288
Cdd:COG0285 186 IKPGVPvVTGDQQPEALEVieeRAAEL-GAPLYRAGRD------FSVEEREGAVFSYQGPGGEYEDLPLplLGAHQAENA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 289 TIAIAV-----GHELGLTYNTIYQNLKNVSLTGmRMEQhtLENDITVIND-AYNasPTSMRAAIDTLSTL--TGRRILIL 360
Cdd:COG0285 259 ALALAAlealrELGLPISEEAIREGLANARWPG-RLEV--LSRGPLVILDgAHN--PAGARALAETLKELfpFRKLHLVF 333
|
.
gi 446534110 361 G 361
Cdd:COG0285 334 G 334
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
107-361 |
1.15e-14 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 75.78 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 107 KVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNynneIGLPL--TILELDNDTEISIlemGMSGFhEIEFLSNLAqPDI 184
Cdd:PRK14106 109 PIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGEDDIIVA---EVSSF-QLETIKEFK-PKV 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 185 AVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPL---LKPHVKE----------------VENAKcISI 245
Cdd:PRK14106 180 GCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRtrsLAKKAKArviffsrkslleegvfVKNGK-IVI 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 246 GVATDNALVCCVDdrdttgisftinnkehyDLPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEQHTLE 325
Cdd:PRK14106 259 SLGGKEEEVIDID-----------------EIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEI 321
|
250 260 270
....*....|....*....|....*....|....*.
gi 446534110 326 NDITVINDAYNASPTsmrAAIDTLSTLTGRRILILG 361
Cdd:PRK14106 322 NGVKFINDSKGTNPD---AAIKALEAYETPIVLIAG 354
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
25-100 |
1.27e-13 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 66.10 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 25 EINGVTIDSRAISKNMLFIPFEGENVDGHRFVSKALQDGAGAAFYQKGT-------PIDENVSGPIIWVEDTLTALQQLA 97
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAAnnispdnPELEAAKVPGIPVIDRREALAELA 80
|
...
gi 446534110 98 QAY 100
Cdd:pfam01225 81 AAF 83
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
93-358 |
7.00e-13 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 70.62 E-value: 7.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 93 LQQLAQAYLRhvnpkvIAVTGSNGKTTTKDMIESVLHTEFKvkktqgNYNNEIGlPLTILELDndteisilemGMSGFHE 172
Cdd:PRK14573 97 LAELMQEQIS------ILVSGSHGKTTVSSLITAIFQEAKK------DPSYAIG-GLNQEGLN----------GYSGSSE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 173 IeFLSNLAQ---------PDIAVITNIGESHMQDL-GSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEvenakc 242
Cdd:PRK14573 154 Y-FVAEADEsdgslkhytPEFSVITNIDNEHLSNFeGDRELLLASIQDFARKVQQINKCFYNGDCPRLKGCLQG------ 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 243 ISIGVATDNALVCCVDDRD--TTGISFTINNKEHYD--LPILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMR 318
Cdd:PRK14573 227 HSYGFSSSCDLHILSYYQEgwRSYFSAKFLGVVYQDieLNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRR 306
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446534110 319 MEQHTLENDITVINDaYNASPTSMRAAIDTLSTLTG-RRIL 358
Cdd:PRK14573 307 LERKNSSETFLFLED-YAHHPSEISCTLRAVRDAVGlRRII 346
|
|
| folC |
TIGR01499 |
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of ... |
103-360 |
5.23e-12 |
|
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273659 [Multi-domain] Cd Length: 397 Bit Score: 67.31 E-value: 5.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 103 HVNPKVIAVTGSNGKTTTKDMIESVL---------------------------------------HTEFKVKKTQGNYN- 142
Cdd:TIGR01499 15 QDLYPVIHVAGTNGKGSTCAFLESILraagykvglftsphlvsfneriringepisdeelaqafeQVRPILESLSQQPTy 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 143 NEIglpLTILEL----DNDTEISILEMGMSGfheiEFLS-NLAQPDIAVITNIGESHMQDLG-SREGIAKAKSEItigLK 216
Cdd:TIGR01499 95 FEL---LTLLAFlyfaQAQVDVAVLEVGLGG----RLDAtNVIEPLVSVITSIGLDHTEILGdTLEEIAWEKAGI---IK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 217 DnGTFIYDGDEPllkPHVKEVENAKCISIGV---ATDNALVCCVDDRDTTGISFTINNKEHYDLPILGKHNMKNATIAIA 293
Cdd:TIGR01499 165 E-GVPIVTGEQE---PEALNVLKKKAQEKGAplfVVGRDFNYSETDENYLSFSGANLFLEPLALSLLGDHQQENAALALA 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446534110 294 -----VGHELGLTYNTIYQNLKNVSLTGmRMEQHTLENDITVINDAYNasPTSMRAAIDTLSTLTGRRILIL 360
Cdd:TIGR01499 241 alevlGKQNPKLSEEAIRQGLANTIWPG-RLEILSEDNPNILLDGAHN--PHSAEALAEWFKKRFNGRPITL 309
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
23-373 |
3.62e-11 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 65.06 E-value: 3.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 23 NQEINGVTIDSRAISKNMLFIPfEGENVDgHRFVSKALQDGAGaaFYQkgTPIDENVSGPIIWVEDTLTALQQLAQAYlr 102
Cdd:PRK14022 31 GVQFDDISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLK--LYV--SEKDYEVGIPQVIVPDIKKAMSLIAMEF-- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 103 HVNP----KVIAVTGSNGKTTTKDMIESVLHTEFK---VKKTQGNYNNE------------IGLPLTILE-LDNDTEISI 162
Cdd:PRK14022 103 YDNPqhklKLLAFTGTKGKTTAAYFAYHILKQLHKpamLSTMNTTLDGEtffksalttpesLDLFKMMAEaVDNGMTHLI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 163 LEMGMSGF-----HEIEFlsnlaqpDIAVITNIGESH--------MQDLGSREGIAKAKSEITIGLKDNGTFiydgdePL 229
Cdd:PRK14022 183 MEVSSQAYlvgrvYGLTF-------DVGVFLNITPDHigpiehptFEDYFYHKRLLMENSKAVVVNSDMDHF------SE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 230 LKphvKEVENAKCISIGVATDNALvccvddRDTTGISFTINNK--EHYDLPILGKHNMKNATIAIAVGHELGLTYNTIYQ 307
Cdd:PRK14022 250 LL---EQVTPQEHDFYGIDSENQI------MASNAFSFEATGKlaGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446534110 308 NLKNVSLTGmRMEQHTLENDITVINDaYNASPTSMRAAIDTLST-LTGRRILILGDVLELGEN-SKEM 373
Cdd:PRK14022 321 GIAQTPVPG-RMEVLTQSNGAKVFID-YAHNGDSLNKLIDVVEEhQKGKLILLLGAAGNKGESrRPDF 386
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
315-395 |
1.41e-09 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 54.66 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 315 TGMRMEQHTLENDITVINDaYNASPTSMRAAIDTLSTLT-GRRILILGDvleLGENSKEMHIGVGnYLEEKHIDVLYTFG 393
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFpGRLILVFGG---MGDRDAEFHALLG-RLAAALADVVILTG 75
|
..
gi 446534110 394 NE 395
Cdd:pfam02875 76 DY 77
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
108-310 |
4.22e-07 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 52.47 E-value: 4.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 108 VIAVTGSNGKTTTKDMIESVLHTEFKV---KKTQGNY-NNEI-------GlPL---TILeLDNDTEISILEMGMSGFHEi 173
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIAHILKLSGKRvgmTTTDGVYiDGRLidkgdctG-PKsarRVL-MNPDVEAAVLETARGGILR- 558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 174 eflSNLA--QPDIAVITNIGESH--MQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLK---PHVKevenAKCISIG 246
Cdd:PRK14016 559 ---EGLAydRCDVGVVTNIGEDHlgLGGINTLEDLAKVKRVVVEAVKPDGYAVLNADDPMVAamaERCK----GKVIFFS 631
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 247 VATDNALVC---------CVDDRDTtgISFTINNKEHY-----DLPIL--GK--HNMKNATIAIAVGHELGLTYNTIYQN 308
Cdd:PRK14016 632 MDPDNPVIAehraqggraVYVEGDY--IVLAEGGWEIRiislaDIPLTlgGKagFNIENALAAIAAAWALGIDIELIRAG 709
|
..
gi 446534110 309 LK 310
Cdd:PRK14016 710 LR 711
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
107-361 |
8.41e-05 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 44.62 E-value: 8.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 107 KVIAVTGSNGKTTTKDMIESVLHTEFKVKKT-QGNYNNEIGL--------PLTILE-LDNDTEISILEMGMSGFhEIEfL 176
Cdd:NF033197 93 KFIEITGVKGKTTTAELLAHILSDEYVLLHTsRGTERYPEGElsnkgsitPASILNaLELAEEIGIDDYGFLIF-EVS-L 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 177 SNLAQPDIAVITNIGESHmqdlgsreGIAK-------AKSEIT-------IGLKDNGTFIYDGDEPLLKPHVKEVENAKC 242
Cdd:NF033197 171 GGTGAGDVGIITNILEDY--------PIAGgkrsasaAKLQSLknakvgsINVADLGIYINGKNKLVITVAGVEILSKYP 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534110 243 IsigvatdnalvccVDDRDTTGISFtiNNKehydlpILGKHNMKNATIAIAVGHELGLTYNTIYQNLKNVSLTGMRMEQH 322
Cdd:NF033197 243 L-------------RFKYGNTEFEF--NPL------LFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPGRMAVK 301
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446534110 323 TLENdITVINdayNASP-TSMRA---AIDTLSTLTGRRILILG 361
Cdd:NF033197 302 KEGG-VVIVD---NINPgLNVKAieyALDDALELLGDGTLVIG 340
|
|
| PLN02913 |
PLN02913 |
dihydrofolate synthetase |
159-211 |
4.98e-03 |
|
dihydrofolate synthetase
Pssm-ID: 178501 [Multi-domain] Cd Length: 510 Bit Score: 39.03 E-value: 4.98e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 446534110 159 EISILEMGMSGFHE---IEFLSNLAQpdiAVITNIGESHMQDL-GSREGIAKAKSEI 211
Cdd:PLN02913 175 DIAVIEAGLGGARDatnVIDSSGLAA---SVITTIGEEHLAALgGSLESIALAKSGI 228
|
|
| |
