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Conserved domains on  [gi|446535339|ref|WP_000612685|]
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MULTISPECIES: homoserine kinase [Bacillus]

Protein Classification

homoserine kinase( domain architecture ID 11479451)

homoserine kinase catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate

CATH:  3.30.230.10|3.30.70.890
EC:  2.7.1.39
Gene Ontology:  GO:0016310|GO:0009088|GO:0004413|GO:0005737|GO:0005524
PubMed:  11188689|11535056
SCOP:  4001303|4000959

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 2.71e-126

homoserine kinase; Provisional


:

Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 362.16  E-value: 2.71e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   1 MIPLSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKAD-----KWQVIHSFEESIPTD-DKNLIVSTACKVCPSIS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  72 PHIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 152 ESKELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446535339 232 RKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFT---DMKVCELEIDHKGIIV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 2.71e-126

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 362.16  E-value: 2.71e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   1 MIPLSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKAD-----KWQVIHSFEESIPTD-DKNLIVSTACKVCPSIS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  72 PHIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 152 ESKELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446535339 232 RKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFT---DMKVCELEIDHKGIIV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 4-292 1.05e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 340.15  E-value: 1.05e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   4 LSVRVPASTANVGPGFDSVGIALSLYLDVVVKE-KADKWQVIHS--FEESIPTDDKNLIVSTACKVC----PSISPHIIE 76
Cdd:COG0083    3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIEgeGADELPTDEDNLVYQAALALLeklgKEPPGLRIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  77 VTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRIE-SKE 155
Cdd:COG0083   83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPvPPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 156 LGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSIRKCA 235
Cdd:COG0083  163 LKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEAA 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446535339 236 KEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTDM----KVCELEIDHKGIIVNKE 292
Cdd:COG0083  242 LEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEAgidaRVYVLKIDNEGARVLES 302
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 4-289 2.94e-80

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 245.00  E-value: 2.94e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339    4 LSVRVPASTANVGPGFDSVGIALSLYLDVVVKE---KADKWQVIHS---FEESIPTD-DKNLIVSTACKVCP----SISP 72
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDvvaQESDDTEIEAegeGVEKIPTEpTDNLIYQVAKRFLDqlgiRMPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   73 HIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRIE 152
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  153 SK-ELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMeRDHFHEPYRLELVPLLPSI 231
Cdd:TIGR00191 161 IFsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446535339  232 RKCAKEFGAYGTALSGAGPSIFILTP----YEKRQEIAEQLARVFTDMKVCELEIDHKGIIV 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADeefaEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 75-135 7.12e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 59.48  E-value: 7.12e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446535339   75 IEVTSNIPLTRGLGSSASAIVAGIEVANQLG-----DLNLTADQKVQIAtnfEGHPDNVAASILGG 135
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGG---RGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 2.71e-126

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 362.16  E-value: 2.71e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   1 MIPLSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKAD-----KWQVIHSFEESIPTD-DKNLIVSTACKVCPSIS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  72 PHIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 152 ESKELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446535339 232 RKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFT---DMKVCELEIDHKGIIV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 4-292 1.05e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 340.15  E-value: 1.05e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   4 LSVRVPASTANVGPGFDSVGIALSLYLDVVVKE-KADKWQVIHS--FEESIPTDDKNLIVSTACKVC----PSISPHIIE 76
Cdd:COG0083    3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIEgeGADELPTDEDNLVYQAALALLeklgKEPPGLRIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  77 VTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRIE-SKE 155
Cdd:COG0083   83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPvPPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 156 LGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSIRKCA 235
Cdd:COG0083  163 LKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEAA 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446535339 236 KEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTDM----KVCELEIDHKGIIVNKE 292
Cdd:COG0083  242 LEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEAgidaRVYVLKIDNEGARVLES 302
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 4-289 2.94e-80

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 245.00  E-value: 2.94e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339    4 LSVRVPASTANVGPGFDSVGIALSLYLDVVVKE---KADKWQVIHS---FEESIPTD-DKNLIVSTACKVCP----SISP 72
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDvvaQESDDTEIEAegeGVEKIPTEpTDNLIYQVAKRFLDqlgiRMPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   73 HIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDISVVRIE 152
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  153 SK-ELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMeRDHFHEPYRLELVPLLPSI 231
Cdd:TIGR00191 161 IFsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446535339  232 RKCAKEFGAYGTALSGAGPSIFILTP----YEKRQEIAEQLARVFTDMKVCELEIDHKGIIV 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADeefaEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
PTZ00299 PTZ00299
homoserine kinase; Provisional
 4-257 7.90e-33

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 123.46  E-value: 7.90e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   4 LSVRVPASTANVGPGFDSVGIALSLYLDVVVkEKADKWQVIHSFE--ESIPTDDKNLIVSTACKVCP-----SISPHIIE 76
Cdd:PTZ00299   8 VVLRVPATTANIGPAYDTLGMALSIFMELTV-EHADAFSMTVEGEgsEHISTDEDNMVVQACRLAFEeyahkSMPPLKFI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  77 VTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQK---VQIATNFEGHPDNVAASILGGTVIG-ALDGKDISVVRIE 152
Cdd:PTZ00299  87 MHSNIPYGCGCGSSSAAAVAGFVAGMKLCGLTMETENEealLQAIAKFEGHPDNAAPAIYGGIQLVyKKDNGRFLTYRVP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 153 SK-ELGVISLIPNE--ELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMmeRDHFHEPYRLElvPLLP 229
Cdd:PTZ00299 167 TPpNLSVVLFVPHNkmKANTHVTRNLIPTSVSLEDAVFNISRTSILVLALSTGDLRMLKSC--SDKLHEQQRSD--ALFP 242

                        250       260       270
                 ....*....|....*....|....*....|.
gi 446535339 230 SIRKC---AKEFGAYGTALSGAGPSIFILTP 257
Cdd:PTZ00299 243 HFRPCvkaAREAGAHYAFLSGAGPSVCALVG 273
PLN02451 PLN02451
homoserine kinase
 9-272 8.67e-28

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 110.27  E-value: 8.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   9 PASTANVGPGFDSVGIALSLYLDVVVKEkadkwqVIHSFE------ESIPTDDKNL----------IVSTACKVCPSISP 72
Cdd:PLN02451  59 PATVANLGPGFDFLGCAVDGLGDFVTAR------VDPGVRpgevsiSEITGDTGRLskdplrncagIAAIATMKLLGIRS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  73 HIIEVTSN--IPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEG-----HPDNVAASILGGTV-IGALDGK 144
Cdd:PLN02451 133 VGLSLSLHkgLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESEAkvsgyHADNIAPALMGGFVlIRSYEPL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 145 DISVVRIES-KELGVISLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMERDHFHEPYRLE 223
Cdd:PLN02451 213 HLIPLRFPSaKDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLGEALSSDKIVEPTRAP 292

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 446535339 224 LVPLLPSIRKCAKEFGAYGTALSGAGPS-IFILTPYEKRQEIAEQLARVF 272
Cdd:PLN02451 293 LIPGMEAVKKAALEAGAYGCTISGAGPTaVAVIDDEEKGEEVGERMVEAF 342
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 75-135 7.12e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 59.48  E-value: 7.12e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446535339   75 IEVTSNIPLTRGLGSSASAIVAGIEVANQLG-----DLNLTADQKVQIAtnfEGHPDNVAASILGG 135
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGG---RGGGMDVAASLYGG 64
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 21-249 1.58e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 57.54  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  21 SVGIALSLYLDVVVKEKADKWQVIHSFE-----ESIPTDDKNL-----IVSTACKVCPSISPHI-IEVTSNIPLTRGLGS 89
Cdd:COG1577   19 AIAVAVDRRATVTVEPSDDDKLRIESPDlggtlDLDPLADAALryikaAIEAALEYLGLPLKGFdIEIDSEIPRKRGLGS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  90 SASAIVAGIEVANQLGDLNLTADQKVQIA--TNFEGHP-----DNvAASILGGTVigALDGKDiSVVRIESKELGVISLI 162
Cdd:COG1577   99 SAAVAVAVIRALAAFYGVELSKEELFKLAleAEKIVHGnpsglDT-AASTYGGPI--YYQRGD-RAEPLELPKNLPLVVG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 163 pneelNTDESRS-------VLPKM----FPFHEAVKASA-ISNVLVAALCQKRWEVVGEMMERDHFHepyRLEL---VPL 227
Cdd:COG1577  175 -----DTGVPAStkelvakVRKLKernpELYEAFLEEIGdLVEEAIEALEEGDLEALGELMNENHGL---LRALgvsTPE 246

                        250       260
                 ....*....|....*....|..
gi 446535339 228 LPSIRKCAKEFGAYGTALSGAG 249
Cdd:COG1577  247 LDRLVEAARKAGALGAKLTGAG 268
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 18-249 4.09e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 56.15  E-value: 4.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   18 GFDSVGIALSLYLDVVVKEKADK--------WQVIHSFEESIPTDDKNLIVSTACKVCPSISPHIIEVTSNIPLTRGLGS 89
Cdd:TIGR00549  16 GEPAIAAPIPLRTTVTVIESSDGsfiesdlgRGSLDDAPDELDGLKYVLAEFLSRFSELNPPPLEITIESEIPPGRGLGS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339   90 SASAIVAGIEVANQLGDLNLTADQKVQIATNFE----GHP---DNvAASILGGTVigaLDGKDISVVRIESKELGVISLI 162
Cdd:TIGR00549  96 SAAVAVALIRALADYFGSELSKEELAELANEAEkiahGKPsgiDT-ATSTSGGPV---YFEKGEGEFTKLISLDGYFVIA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  163 pneelNTDESRS---------VLPKMFPfhEAVKAS-----AISNVLVAALCQKRWEVVGEMMERDHfhepyrlEL---- 224
Cdd:TIGR00549 172 -----DTGVSGStkeavarvrQLLERFP--ELIDSImdaigELTLEAKAALQDGDVESLGELMNINQ-------GLlkal 237

                         250       260
                  ....*....|....*....|....*...
gi 446535339  225 ---VPLLPSIRKCAKEFGAYGTALSGAG 249
Cdd:TIGR00549 238 gvsHPKLDQLVEIARKAGALGAKLTGAG 265
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 195-272 3.26e-07

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 47.46  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  195 LVAALCQKRWEVVGEMMERDHF-HEP--YRLELVPLLPSIRKCAKEFGaYGTALSGA--GPSIFILTPYEKR-QEIAEQL 268
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAEsLEPllVVGILPPELDELLEALLELG-LGAKLSGSggGPTVFALFKDEDDaEEVARAL 79


                  ....
gi 446535339  269 ARVF 272
Cdd:pfam08544  80 REAG 83
PRK03926 PRK03926
mevalonate kinase; Provisional
 53-266 2.14e-06

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 48.13  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  53 TDDKNLIVSTACKVCPSISPH---IIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQ------KVQIATNFEG 123
Cdd:PRK03926  53 TGEKHPYVSAAIEKMREEADKdgvTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEiaklghKVELLVQGAA 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 124 HPDNVAASILGGTVIgALDGKDISVVrieskELGVI-----SLIPNEEL--NTDESRSVLPKMF-PFHEAV-KASAISNV 194
Cdd:PRK03926 133 SPTDTYVSTMGGFVT-IPDRKKLPFP-----ECGIVvgytgSSGSTKELvaNVRKLKEEYPELIePILSSIgKISEKGEE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 195 LVaalCQKRWEVVGEMMERDHfhepyRL---------ELVPLLPSIRKCakefGAYGTALSGAGPS--IFILTPYEKRQE 263
Cdd:PRK03926 207 LI---LSGDYVSLGELMNINQ-----GLldalgvstkELSELIYAARTA----GALGAKITGAGGGgcMVALAAPEKQSE 274


                 ...
gi 446535339 264 IAE 266
Cdd:PRK03926 275 VAT 277
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
157-275 4.67e-04

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 41.04  E-value: 4.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 157 GVISLIPnEELNTDESRSVLPKmfPFHEAVKA---SAISNVLVAALCQKRWEVVGEMMERDHfhEPYRLELVPLLPSIRK 233
Cdd:PRK14613 173 GILALTP-QVMNTGEMYALLKK--PLQESASQkngNTLSEDLISSLKVGDWVSLQGRLENDF--EPVAFQLHPELGVLKD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446535339 234 CAKEFGAYGTALSGAGPSIFILTP-YEKRQEIAEQLARVFTDM 275
Cdd:PRK14613 248 KFLEFGSSYCSLTGSGSSMYGLVQgLEIQEELLPRLRQEFSNL 290
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 75-272 1.31e-03

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 39.84  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339  75 IEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIATNFEG-----HPDNVAASILGGTVIGALDgkdisvv 149
Cdd:COG4542   73 IELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIEPtdstmFPGLVLFDHREGRVLEPLG------- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446535339 150 riESKELGVISLIPNEELNTDE-SRSVLPKMFPFHEAVKASAIsNVLVAALCQKRWEVVGEMMERDHF----HEPYrlel 224
Cdd:COG4542  146 --PLPPLDILGLDSGGTVDTLAfNRRDLAELNRAEEPEIERAL-ALLREALRTGDLALLGEAATLSARanqrILPK---- 218

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446535339 225 vPLLPSIRKCAKEFGAYG--TALSG--AGpsifIL-----TPYEKR-QEIAEQLARVF 272
Cdd:COG4542  219 -PELEELLALAEELGALGvnVAHSGtvLG----LLfdpgdHDVEKLaEALRRRLLRLG 271
PRK03817 PRK03817
galactokinase; Provisional
 70-118 1.33e-03

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 39.98  E-value: 1.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446535339  70 ISPHIIEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTADQKVQIA 118
Cdd:PRK03817  84 VGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLA 132
PRK05101 PRK05101
galactokinase; Provisional
 75-120 7.29e-03

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 37.60  E-value: 7.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446535339  75 IEVTSNIPLTRGLGSSASAIVAGIEVANQLGDLNLTadqKVQIATN 120
Cdd:PRK05101 115 LVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLS---GAEIALN 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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