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Conserved domains on  [gi|446537604|ref|WP_000614950|]
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MurR/RpiR family transcriptional regulator [Escherichia coli]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 14-289 1.73e-56

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 183.59  E-value: 1.73e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  14 ERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWLGPALSSSEKM 93
Cdd:COG1737    9 ERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYERL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  94 STtvSNLTSDVNTAIDFVLEGHLYTCNVLSEPENRHALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPATAL 173
Cdd:COG1737   89 RR--LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 174 NRTGIGLAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPRGDEK---GKTP 250
Cdd:COG1737  167 DGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTlrsSAFS 246

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446537604 251 LHGTVLLCLEMIVWSVASAVPQRAVKTIKRINDFHRGLK 289
Cdd:COG1737  247 SRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELR 285
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 14-289 1.73e-56

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 183.59  E-value: 1.73e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  14 ERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWLGPALSSSEKM 93
Cdd:COG1737    9 ERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYERL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  94 STtvSNLTSDVNTAIDFVLEGHLYTCNVLSEPENRHALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPATAL 173
Cdd:COG1737   89 RR--LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 174 NRTGIGLAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPRGDEK---GKTP 250
Cdd:COG1737  167 DGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTlrsSAFS 246

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446537604 251 LHGTVLLCLEMIVWSVASAVPQRAVKTIKRINDFHRGLK 289
Cdd:COG1737  247 SRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELR 285
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 130-241 5.64e-19

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 81.12  E-value: 5.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 130 ALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPATALNRTGIGLAEQLIaLQRGDVLIMMAQKSAHREGLTTL 209
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAAN-LTPGDVVIAISFSGETKETVEAA 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446537604 210 REARRLGIPVILLTNALDSRFSKDASIVIHVP 241
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVS 112
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
14-240 3.47e-17

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 81.50  E-value: 3.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  14 ERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTleqwLGPALSSSEKM 93
Cdd:PRK14101 345 ERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLK----LATGLTGTIPM 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  94 STTVSNLTsdvNTAIDF---VLEGHLYTCNVLSEPENRHALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPA 170
Cdd:PRK14101 421 SHSQVHLG---DTATDFgakVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPT 497

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 171 TALNRTGIGLAEQLIaLQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNAlDSRFSKDASIVIHV 240
Cdd:PRK14101 498 IAYGDLYMQAASAAL-LGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSS-NTPLAKRATVALET 565
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 137-256 6.36e-11

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 58.85  E-value: 6.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  137 LLVQARQVAIFGIGASGILADYTARLFNRIGLPATALNRTGIGLAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLG 216
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446537604  217 IPVILLTNALDSRFSKDASIVIHVPRGDEKGKTPLHGTVL 256
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVLYINAGPETGVASTKSITA 120
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 14-289 1.73e-56

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 183.59  E-value: 1.73e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  14 ERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWLGPALSSSEKM 93
Cdd:COG1737    9 ERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYERL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  94 STtvSNLTSDVNTAIDFVLEGHLYTCNVLSEPENRHALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPATAL 173
Cdd:COG1737   89 RR--LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 174 NRTGIGLAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPRGDEK---GKTP 250
Cdd:COG1737  167 DGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTlrsSAFS 246

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446537604 251 LHGTVLLCLEMIVWSVASAVPQRAVKTIKRINDFHRGLK 289
Cdd:COG1737  247 SRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELR 285
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 130-241 5.64e-19

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 81.12  E-value: 5.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 130 ALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPATALNRTGIGLAEQLIaLQRGDVLIMMAQKSAHREGLTTL 209
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAAN-LTPGDVVIAISFSGETKETVEAA 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446537604 210 REARRLGIPVILLTNALDSRFSKDASIVIHVP 241
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVS 112
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 144-226 3.00e-18

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 77.80  E-value: 3.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 144 VAIFGIGASGILADYTARLFNRI-GLPATALNRTGIGLAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILL 222
Cdd:cd04795    1 IFVIGIGGSGAIAAYFALELLELtGIEVVALIATELEHASLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                 ....
gi 446537604 223 TNAL 226
Cdd:cd04795   81 TDAL 84
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
14-240 3.47e-17

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 81.50  E-value: 3.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  14 ERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTleqwLGPALSSSEKM 93
Cdd:PRK14101 345 ERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLK----LATGLTGTIPM 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  94 STTVSNLTsdvNTAIDF---VLEGHLYTCNVLSEPENRHALAQAVALLVQARQVAIFGIGASGILADYTARLFNRIGLPA 170
Cdd:PRK14101 421 SHSQVHLG---DTATDFgakVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPT 497

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 171 TALNRTGIGLAEQLIaLQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNAlDSRFSKDASIVIHV 240
Cdd:PRK14101 498 IAYGDLYMQAASAAL-LGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSS-NTPLAKRATVALET 565
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
13-253 5.92e-16

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 76.34  E-value: 5.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  13 GERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWlgpalsssek 92
Cdd:PRK11337  16 GPYIRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDY---------- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  93 MSTTVSNLTSDV---NTAIDFVLEGHLYTCNVLSEPE---NRHALAQAVALLVQARQVAIFGIGASGILADYTARLFNRI 166
Cdd:PRK11337  86 FSQSEQVLHSELsfdDAPQDVVNKVFNTSLQAIEETQsilDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRI 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 167 GLPATALNRTGIGLAEQLIaLQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPRGDek 246
Cdd:PRK11337 166 GVRCQAYDDAHIMLMSAAL-LQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTAQG-- 242


                 ....*..
gi 446537604 247 gkTPLHG 253
Cdd:PRK11337 243 --SPLLG 247
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 137-256 6.36e-11

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 58.85  E-value: 6.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  137 LLVQARQVAIFGIGASGILADYTARLFNRIGLPATALNRTGIGLAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLG 216
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446537604  217 IPVILLTNALDSRFSKDASIVIHVPRGDEKGKTPLHGTVL 256
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVLYINAGPETGVASTKSITA 120
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
11-249 2.98e-10

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 59.71  E-value: 2.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  11 IYGERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLeqwLGPALSSS 90
Cdd:PRK15482   2 LYLTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMAL---IGEYSASR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  91 EKMSTTV----SNLTSD---------VNTAIDFVLEghlYTCNVLsepeNRHALAQAVALLVQARQVAIFGIGASGILA- 156
Cdd:PRK15482  79 EKTNATAlhlhSSITSDdsleviarkLNREKELALE---QTCALF----DYARLQKIIEVISKAPFIQITGLGGSALVGr 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 157 DYTARLFnRIGLPATALNRTGIGlAEQLIALQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNALDSRFSKDASI 236
Cdd:PRK15482 152 DLSFKLM-KIGYRVACEADTHVQ-ATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHF 229

                        250
                 ....*....|...
gi 446537604 237 VIHVPRGDEKGKT 249
Cdd:PRK15482 230 TLDTVSGETEWRS 242
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
18-229 3.16e-10

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 59.39  E-value: 3.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  18 TRASQLTPGL----RAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWLgpaLSSSEKM 93
Cdd:PRK11557   1 LRIRQRYPGLaqsdRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEAL---ASQPEPP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  94 STTVSN--LTSDvntAIDFVLEGHLY--------TCNVLSEPEnrhaLAQAVALLVQARQVAIFGIGASGILADYTARLF 163
Cdd:PRK11557  78 SVPVHNqiRGDD---PLRLVGEKLIKentaamraTLDVNSEEK----LHECVTMLRSARRIILTGIGASGLVAQNFAWKL 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 164 NRIGLPATALNRTGIGLAeQLIALQRGDVLIMMAQKSAHREGLTTLREARRLGIPVILLT----NALDSR 229
Cdd:PRK11557 151 MKIGINAVAERDMHALLA-TVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITgftpNALQQR 219
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 14-241 7.28e-10

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 58.47  E-value: 7.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  14 ERFRTRASQLTPGLRAVAsyinehrEVVLD--QTAME-----IAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWLG-- 84
Cdd:PRK11302   5 EKIQSRLEHLSKSERKVA-------EVILAspQTAIHssiatLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLAng 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  85 -PALSSSEKMSTTVSNLTSDVNTAIDFVLEghlYTCNVLSEpenrHALAQAVALLVQARQVAIFGIGASGILADYTARLF 163
Cdd:PRK11302  78 tPYVNRNVEEDDSVEAYTGKIFESAMASLD---HARQSLDP----SAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKF 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 164 NRIGLPATALNRtgiglaeqlIALQR--------GDVLIMMAQKSAHREGLTTLREARRLGIPVILLTNAlDSRFSKDAS 235
Cdd:PRK11302 151 FRFNVPVVYFDD---------IVMQRmscmnssdGDVVVLISHTGRTKSLVELAQLARENGATVIAITSA-GSPLAREAT 220


                 ....*.
gi 446537604 236 IVIHVP 241
Cdd:PRK11302 221 LALTLD 226
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 144-245 4.00e-09

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 53.70  E-value: 4.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 144 VAIFGIGASGILADYTARLFNRIGLPATALNRT-----GIGLaeqliaLQRGDVLIMMAQKSAHREGLTTLREARRLGIP 218
Cdd:cd05014    3 VVVTGVGKSGHIARKIAATLSSTGTPAFFLHPTealhgDLGM------VTPGDVVIAISNSGETDELLNLLPHLKRRGAP 76

                         90       100
                 ....*....|....*....|....*..
gi 446537604 219 VILLTNALDSRFSKDASIVIHVPRGDE 245
Cdd:cd05014   77 IIAITGNPNSTLAKLSDVVLDLPVEEE 103
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 126-247 3.52e-08

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 53.75  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 126 ENRHALAQAVALLVQARQVAIF--GIGASGILADYTARLFNR-IGLPATAlnrtgIGLAEQLIALQ----RGDVLIMMAQ 198
Cdd:COG2222   17 ALAAAIAALLARLRAKPPRRVVlvGAGSSDHAAQAAAYLLERlLGIPVAA-----LAPSELVVYPAylklEGTLVVAISR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446537604 199 --KSAhrEGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPRGDEKG 247
Cdd:COG2222   92 sgNSP--EVVAALELAKARGARTLAITNNPDSPLAEAADRVLPLPAGPEKS 140
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 14-85 8.42e-08

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 48.87  E-value: 8.42e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446537604   14 ERFRTRASQLTPGLRAVASYINEHREVVLDQTAMEIAATLNTSDATVIRAIQALGFAGLRDLKRTLEQWLGP 85
Cdd:pfam01418   5 EKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELAN 76
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 119-263 1.52e-04

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 41.79  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 119 CNVLSEPENRHaLAQAVALLVQARQVAIFGIGASGILADYTA-RLFNrIGLPATALNRTgiglaeqlI--ALQRGDVLIM 195
Cdd:cd05005   12 ENVADKIDEEE-LDKLISAILNAKRIFVYGAGRSGLVAKAFAmRLMH-LGLNVYVVGET--------TtpAIGPGDLLIA 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446537604 196 MAQKSAHREGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPR-------GDEKGKTPL----HGTVLLCLEMIV 263
Cdd:cd05005   82 ISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAatkddhgGEHKSIQPLgtlfEQSALVFLDAVI 160
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 130-245 3.46e-04

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 41.50  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 130 ALAQAVALLVQAR-QVAIFGIGASGILADYTARLFNRIGLPATALNRT-------GIglaeqliaLQRGDVLIMMAQKSA 201
Cdd:COG0794   32 SFEKAVELILNCKgRVVVTGMGKSGHIARKIAATLASTGTPAFFLHPAeashgdlGM--------ITPGDVVIAISNSGE 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446537604 202 HREGLTTLREARRLGIPVILLTNALDSRFSKDASIVIHVPRGDE 245
Cdd:COG0794  104 TEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLPVERE 147
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 144-247 2.14e-03

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 37.48  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 144 VAIFGIGASGILADYTARLFNRI-GLPATA------LNRTGIglaeqliaLQRGDVLIMMAQ--KSAhrEGLTTLREARR 214
Cdd:cd05008    2 ILIVGCGTSYHAALVAKYLLERLaGIPVEVeaasefRYRRPL--------LDEDTLVIAISQsgETA--DTLAALRLAKE 71

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446537604 215 LGIPVILLTNALDSRFSKDASIVIHVPRGDEKG 247
Cdd:cd05008   72 KGAKTVAITNVVGSTLAREADYVLYLRAGPEIS 104
PRK02947 PRK02947
sugar isomerase domain-containing protein;
130-244 3.46e-03

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 38.31  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 130 ALAQAVALLVQARQ----VAIFGIGASGILADYTA-R-----LFNRIGLP----------ATALNRTGiGLAEQLIA--- 186
Cdd:PRK02947  25 AIEKAADLIADSIRngglIYVFGTGHSHILAEEVFyRagglaPVNPILEPslmlhegavaSSYLERVE-GYAKAILDryd 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604 187 LQRGDVLIM------------MAQksahreglttlrEARRLGIPVILLTN-----ALDSRFS-----KD-ASIVI--HVP 241
Cdd:PRK02947 104 IRPGDVLIVvsnsgrnpvpieMAL------------EAKERGAKVIAVTSlaysaSVASRHSsgkrlAEvADVVLdnGAP 171


                 ...
gi 446537604 242 RGD 244
Cdd:PRK02947 172 KGD 174
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 124-223 3.51e-03

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 37.19  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  124 EPENRHALAQAVALLVQA----RQVAIFGIGASGILA-DYTARL-----FNRIGLPATAL-------NRTGI----GLAE 182
Cdd:pfam13580  14 VETQADAIEKAADLIAASlangGKVYAFGTGHSAAPAeELFARAgglagFEPILLPALALhtdasatISTALerdeGYAR 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 446537604  183 QLIALQR---GDVLIMMAQKSAHREGLTTLREARRLGIPVILLT 223
Cdd:pfam13580  94 QILALYPgrpGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
ASKHA_NBD_EutJ cd24047
nucleotide-binding domain (NBD) of ethanolamine utilization protein EutJ and similar proteins; ...
 40-150 5.40e-03

nucleotide-binding domain (NBD) of ethanolamine utilization protein EutJ and similar proteins; EutJ may protect ethanolamine ammonia-lyase (EAL, eutB-eutC) from inhibition. It may also function in assembling the bacterial microcompartment and/or in refolding EAL, suggesting it may have chaperone activity.


Pssm-ID: 466897 [Multi-domain]  Cd Length: 241  Bit Score: 37.63  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446537604  40 VVLDQTAMEIAATLNTSDatVIRAIQALGFAG----LRDLKRTLEQWLGPALSSSekmSTTVSNLTSDVNT-AIDFVLEG 114
Cdd:cd24047   15 VVVDEEGQPVAGALERAD--VVRDGIVVDYIGairiVRKLKETLEKKLGVELTSA---ATAFPPGTGERDArAIRNVLEG 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446537604 115 HLYTC-NVLSEPenrhalaQAVALLVQARQVAIFGIG 150
Cdd:cd24047   90 AGLEVsNVVDEP-------TAANAVLGIRDGAVVDIG 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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