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Conserved domains on  [gi|446542873|ref|WP_000620219|]
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MULTISPECIES: heme biosynthesis protein HemY [Vibrio]

Protein Classification

heme biosynthesis protein HemY( domain architecture ID 11489224)

heme biosynthesis protein HemY similar to Escherichia coli HemY, is found in heme biosynthesis gene clusters and contains tetratricopeptide repeats (TPRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 20-386 3.55e-140

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


:

Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 403.98  E-value: 3.55e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   20 QYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGD 99
Cdd:TIGR00540   1 ALAGNTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  100 WTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQ-QNNSTLAVELTRAKQQLGDGDNQAALETLTQL 178
Cdd:TIGR00540  81 YSQAEKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAElAPNSELAVLLTRAELLLDQRDYEAALAALDSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  179 QRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDiASQKGSEGLVQHWAQLSRKL 258
Cdd:TIGR00540 161 QAQAPRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDE-AREEDADALKTWWKQLPRAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  259 KAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEALRRDGNNAEAHSALGQLYL 338
Cdd:TIGR00540 240 RQEPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCL 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 446542873  339 REKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKA 386
Cdd:TIGR00540 320 RQQLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
 
Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 20-386 3.55e-140

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 403.98  E-value: 3.55e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   20 QYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGD 99
Cdd:TIGR00540   1 ALAGNTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  100 WTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQ-QNNSTLAVELTRAKQQLGDGDNQAALETLTQL 178
Cdd:TIGR00540  81 YSQAEKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAElAPNSELAVLLTRAELLLDQRDYEAALAALDSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  179 QRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDiASQKGSEGLVQHWAQLSRKL 258
Cdd:TIGR00540 161 QAQAPRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDE-AREEDADALKTWWKQLPRAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  259 KAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEALRRDGNNAEAHSALGQLYL 338
Cdd:TIGR00540 240 RQEPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCL 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 446542873  339 REKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKA 386
Cdd:TIGR00540 320 RQQLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 88-390 2.79e-87

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 267.55  E-value: 2.79e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  88 TNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQQN-NSTLAVELTRAKQQLGDG 166
Cdd:COG3071   20 LLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELApEAELAVLLTRAELLLDQG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 167 DNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAsqKGSEG 246
Cdd:COG3071  100 QAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQAA--RDAEA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 247 LVQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEALRRDGNN 326
Cdd:COG3071  178 LKALWKALPRAERRDPELAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKQLKRAEKWLKKHPND 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446542873 327 AEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSLL 390
Cdd:COG3071  258 PDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALA 321
PRK10747 PRK10747
putative protoheme IX biogenesis protein; Provisional
 1-389 1.72e-82

putative protoheme IX biogenesis protein; Provisional


Pssm-ID: 182695 [Multi-domain]  Cd Length: 398  Bit Score: 257.71  E-value: 1.72e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   1 MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRK 80
Cdd:PRK10747   1 MLKVLLLFVLLIAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGARTRGWFVGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  81 QRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQ-QNNSTLAVELTRA 159
Cdd:PRK10747  81 RRRARKQTEQALLKLAEGDYQQVEKLMTRNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAElADNDQLPVEITRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 160 KQQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIA 239
Cdd:PRK10747 161 RIQLARNENHAARHGVDKLLEVAPRHPEVLRLAEQAYIRTGAWSSLLDILPSMAKAHVGDEEHRAMLEQQAWIGLMDQAM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 240 SQKGSEGLVQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEA 319
Cdd:PRK10747 241 ADQGSEGLKRWWKNQSRKTRHQVALQVAMAEHLIECDDHDTAQQIILDGLKRQYDERLVLLIPRLKTNNPEQLEKVLRQQ 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 320 LRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:PRK10747 321 IKQHGDTPLLWSTLGQLLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLML 390
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 29-132 5.60e-24

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 95.27  E-value: 5.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   29 LISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGDWTQAEKKVT 108
Cdd:pfam07219   1 LIVWGGYRIETSLWVAVLLLVLLFVLLYLLLRLLRLLLRLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAA 80

                          90       100
                  ....*....|....*....|....
gi 446542873  109 RWANHHDMPLLCYLVASEAANGMG 132
Cdd:pfam07219  81 KAAKLLDAPLLNYLLAARAAQLQG 104
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 313-398 1.79e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLrEKHWAD-AQKHLEKALSLRSS--VSDYAYLA---DALEKQNFTRAAHDVSRKA 386
Cdd:cd24142   20 LKFLQRALELEPNNVEALELLGEILL-ELGDVEeAREVLLRAIELDPDggYEKYLYLGqlsGGEEALQYYEKGIEILEEE 98

                         90
                 ....*....|..
gi 446542873 387 LSLLESPSAQSS 398
Cdd:cd24142   99 LQALQAASAEAE 110
 
Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 20-386 3.55e-140

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 403.98  E-value: 3.55e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   20 QYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGD 99
Cdd:TIGR00540   1 ALAGNTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  100 WTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQ-QNNSTLAVELTRAKQQLGDGDNQAALETLTQL 178
Cdd:TIGR00540  81 YSQAEKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAElAPNSELAVLLTRAELLLDQRDYEAALAALDSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  179 QRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDiASQKGSEGLVQHWAQLSRKL 258
Cdd:TIGR00540 161 QAQAPRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDE-AREEDADALKTWWKQLPRAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  259 KAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEALRRDGNNAEAHSALGQLYL 338
Cdd:TIGR00540 240 RQEPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCL 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 446542873  339 REKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKA 386
Cdd:TIGR00540 320 RQQLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 88-390 2.79e-87

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 267.55  E-value: 2.79e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  88 TNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQQN-NSTLAVELTRAKQQLGDG 166
Cdd:COG3071   20 LLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELApEAELAVLLTRAELLLDQG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 167 DNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAsqKGSEG 246
Cdd:COG3071  100 QAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQAA--RDAEA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 247 LVQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEALRRDGNN 326
Cdd:COG3071  178 LKALWKALPRAERRDPELAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKQLKRAEKWLKKHPND 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446542873 327 AEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSLL 390
Cdd:COG3071  258 PDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALA 321
PRK10747 PRK10747
putative protoheme IX biogenesis protein; Provisional
 1-389 1.72e-82

putative protoheme IX biogenesis protein; Provisional


Pssm-ID: 182695 [Multi-domain]  Cd Length: 398  Bit Score: 257.71  E-value: 1.72e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   1 MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRK 80
Cdd:PRK10747   1 MLKVLLLFVLLIAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGARTRGWFVGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  81 QRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQ-QNNSTLAVELTRA 159
Cdd:PRK10747  81 RRRARKQTEQALLKLAEGDYQQVEKLMTRNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAElADNDQLPVEITRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 160 KQQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIA 239
Cdd:PRK10747 161 RIQLARNENHAARHGVDKLLEVAPRHPEVLRLAEQAYIRTGAWSSLLDILPSMAKAHVGDEEHRAMLEQQAWIGLMDQAM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 240 SQKGSEGLVQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEA 319
Cdd:PRK10747 241 ADQGSEGLKRWWKNQSRKTRHQVALQVAMAEHLIECDDHDTAQQIILDGLKRQYDERLVLLIPRLKTNNPEQLEKVLRQQ 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 320 LRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:PRK10747 321 IKQHGDTPLLWSTLGQLLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLML 390
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 29-132 5.60e-24

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 95.27  E-value: 5.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   29 LISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGDWTQAEKKVT 108
Cdd:pfam07219   1 LIVWGGYRIETSLWVAVLLLVLLFVLLYLLLRLLRLLLRLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAA 80

                          90       100
                  ....*....|....*....|....
gi 446542873  109 RWANHHDMPLLCYLVASEAANGMG 132
Cdd:pfam07219  81 KAAKLLDAPLLNYLLAARAAQLQG 104
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 1-374 3.20e-14

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 73.77  E-value: 3.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   1 MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRK 80
Cdd:COG3898    1 MIRILLFLALVAALALGAAWLADRPGTVSITWLGYEIETSLLVAAIALLVLAAAVWLLWRLLRFLLGSPTALSRYFRRRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  81 QRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAK-RDHYLALAaqQNNSTLAVELtR- 158
Cdd:COG3898   81 RRKGYQALSRGLIAVAAGDGRLARRKAAKAERLLDRPPLTLLLEAQAAQLAGDREAaRRAFEAML--EDPETRFLGL-Rg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 159 -AKQQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNE------------EAQQ 225
Cdd:COG3898  158 lMVEALRRGDTEAALALAEEALALAPKLPWAQDALLELQAAAGDWDGALATLDAALKAGLLDKDvarrrravlltaRARE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 226 LEITAQRGILQD-IASQKGSEGLVQHWAQLSRKLKAEPELlmcfitqliqRKADyeafSMIKESLKKQATPEL---YA-L 300
Cdd:COG3898  238 LEEGDPDEARELaIEALKLAPDLVPAAVLAARLLIAQGKL----------RKAA----KVLEKAWRAQPHPDLaaaYAeL 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446542873 301 LPELNISDRhplIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQN 374
Cdd:COG3898  304 RPGDSALDR---LKRAETLAALNPDHPESRLALAEAALAAGDFGEARRALGPLLEERPTARVCLLMAEIERGEH 374
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 144-387 4.05e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 4.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 144 AAQQNNSTLAVELTRAKQQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKaKRLSNEEA 223
Cdd:COG2956   34 ALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE-LDPDDAEA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 224 QQLeitaqrgiLQDIASQKGSEGLVQHWAQLSRKLKAEPELLMCFITQLIQRKADYE-AFSMIKESLKKQAT-PELYALL 301
Cdd:COG2956  113 LRL--------LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDeAIEALEKALKLDPDcARALLLL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 302 PELNISDRHP--LIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAA 379
Cdd:COG2956  185 AELYLEQGDYeeAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAA 264


                 ....*...
gi 446542873 380 HDVSRKAL 387
Cdd:COG2956  265 LALLERQL 272
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 312-389 3.66e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.63  E-value: 3.66e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446542873 312 LIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLR-SSVSDYAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDpDNADALLDLAEALLAAGDTEEAEELLERALAL 80
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 124-367 1.08e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.84  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 124 ASEAANGMGDRAKRDHYLALAAQQNNSTLAVELTRAKQQLGdgdnqaaLETLTQLQRNHPHNTVVLNLLKQCYQALGEWQ 203
Cdd:COG3914    2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALG-------LALLLLAALAEAAAAALLALAAGEAAAAAAAL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 204 PLLALLPKLVKAKRLSNEEAQQLEITAQRGIlqdiASQKGSEGLVQHWAQLSRKLKAEPELLMCFiTQLIQRKADY-EAF 282
Cdd:COG3914   75 LLLAALLELAALLLQALGRYEEALALYRRAL----ALNPDNAEALFNLGNLLLALGRLEEALAAL-RRALALNPDFaEAY 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 283 SMIKESLKKQATPELyallpelnisdrhpLIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSD 362
Cdd:COG3914  150 LNLGEALRRLGRLEE--------------AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNAD 215


                 ....*
gi 446542873 363 YAYLA 367
Cdd:COG3914  216 AHSNL 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 158-395 2.41e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 158 RAKQQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQD 237
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 238 IAsqkgseglVQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQ-ATPELYALLPELNISDRHPL--IA 314
Cdd:COG2956   94 RA--------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpENAHAYCELAELYLEQGDYDeaIE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 315 LLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSL-RSSVSDYAYLADALEKQNFTRAAHDVSRKALSLLESP 393
Cdd:COG2956  166 ALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQdPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245


                 ..
gi 446542873 394 SA 395
Cdd:COG2956  246 DL 247
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 313-389 1.12e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLR-SSVSDYAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG4783   58 IVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDpEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 313-389 3.56e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 3.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSD-YAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG4783   24 EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEaRLNLGLALLKAGDYDEALALLEKALKL 101
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 313-372 6.21e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.38  E-value: 6.21e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEK 372
Cdd:COG4235   71 EELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 93-233 1.10e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.65  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  93 IKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQQNNSTLAVELTRAKQQLGDGDNQAAL 172
Cdd:COG2956  119 IYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446542873 173 ETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRG 233
Cdd:COG2956  199 AALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKE 259
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
313-389 1.54e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 1.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSD-YAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG0457   28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEaLNNLGLALQALGRYEEALEDYDKALEL 105
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
313-389 2.55e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.38  E-value: 2.55e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSD-YAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG0457   62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEaLYNLGLALLELGRYDEAIEAYERALEL 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 313-389 5.35e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 5.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAY-LADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG5010   74 LALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSnLAALLLSLGQDDEAKAALQRALGT 151
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 128-357 6.70e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 6.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 128 ANGMGDRAKRDHYLALAAQQNNSTLAVELTRAKQQLGDGDNqaALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLA 207
Cdd:COG2956   54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR--AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 208 LLPKLVKakrLSNEEAQQLEITAQrgilqdIASQKGSEGLVQHWAQLSRKLKAEPELLMCFITQLIQRKADY-EAFSMIK 286
Cdd:COG2956  132 VLERLLK---LGPENAHAYCELAE------LYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYeEAIAALE 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446542873 287 ESLKKQatPELYALLPEL-----NISDRHPLIALLQEALRRDGNNAeAHSALGQLYLREKHWADAQKHLEKALSLR 357
Cdd:COG2956  203 RALEQD--PDYLPALPRLaelyeKLGDPEEALELLRKALELDPSDD-LLLALADLLERKEGLEAALALLERQLRRH 275
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 99-279 7.89e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 44.41  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  99 DWTQAEKKVTRWANHHDMPL-------LCYLVASEAANGMGDRAKRdhYLALAAQQNNSTLAVELTRAKQQLGDGDNQAA 171
Cdd:PRK11788 156 DWQKAIDVAERLEKLGGDSLrveiahfYCELAQQALARGDLDAARA--LLKKALAADPQCVRASILLGDLALAQGDYAAA 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 172 LETLTQL-QRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKR-LSNEEAQQLEITAQRGIlqDIASQKGSEGL-- 247
Cdd:PRK11788 234 IEALERVeEQDPEYLSEVLPKLMECYQALGDEAEGLEFLRRALEEYPgADLLLALAQLLEEQEGP--EAAQALLREQLrr 311

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446542873 248 ------VQHWAQLsRKLKAEP-------ELLMCFITQLIQRKADY 279
Cdd:PRK11788 312 hpslrgFHRLLDY-HLAEAEEgrakeslLLLRDLVGEQLKRKPRY 355
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
313-389 7.93e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 7.93e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKhLEKALSLRSSVSD-YAYLADALEKQNFTRAAHDVSRKALSL 389
Cdd:COG3063   12 EEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEaLLNLAELLLELGDYDEALAYLERALEL 88
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 313-356 1.04e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 44.69  E-value: 1.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446542873  313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSL 356
Cdd:PRK11447  289 IPELQQAVRANPKDSEALGALGQAYSQQGDRARAVAQFEKALAL 332
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
313-387 2.84e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 2.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSD-YAYLADALEKQNFTRAAHDVSRKAL 387
Cdd:COG0457   96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADaLYNLGIALEKLGRYEEALELLEKLE 171
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 313-374 1.43e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 1.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446542873  313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYA-YLADALEKQN 374
Cdd:TIGR02917  42 IIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLpLLARAYLLQG 104
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 313-398 1.79e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 313 IALLQEALRRDGNNAEAHSALGQLYLrEKHWAD-AQKHLEKALSLRSS--VSDYAYLA---DALEKQNFTRAAHDVSRKA 386
Cdd:cd24142   20 LKFLQRALELEPNNVEALELLGEILL-ELGDVEeAREVLLRAIELDPDggYEKYLYLGqlsGGEEALQYYEKGIEILEEE 98

                         90
                 ....*....|..
gi 446542873 387 LSLLESPSAQSS 398
Cdd:cd24142   99 LQALQAASAEAE 110
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 327-356 2.17e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 2.17e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 446542873  327 AEAHSALGQLYLREKHWADAQKHLEKALSL 356
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALEL 30
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-370 2.36e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873   91 GIIKLLEGDWTQAEK--KVTRWANHHDMPLLCYLVASEAANGMGDRAKRDHYLALAAQQNNstLAVELTRAKQQLGDGDN 168
Cdd:TIGR02917 472 GAIYLGKGDLAKAREafEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN--LRAILALAGLYLRTGNE 549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  169 QAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRlSNEEAQQLEITAQrgiLQDIASQKGSEGLv 248
Cdd:TIGR02917 550 EEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAP-DSPEAWLMLGRAQ---LAAGDLNKAVSSF- 624

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  249 QHWAQLSRKlKAEPELLMCFItQLIQRKADyEAFSMIKESLK-KQATPELYALLPELNISDRHPLIA--LLQEALRRDGN 325
Cdd:TIGR02917 625 KKLLALQPD-SALALLLLADA-YAVMKNYA-KAITSLKRALElKPDNTEAQIGLAQLLLAAKRTESAkkIAKSLQKQHPK 701

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 446542873  326 NAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADAL 370
Cdd:TIGR02917 702 AALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRAL 746
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 303-372 3.93e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.02  E-value: 3.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873 303 ELNISDRHPLIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSlrssvSDYAYLADALEK 372
Cdd:PRK11788 190 ALARGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEE-----QDPEYLSEVLPK 254
TPR_19 pfam14559
Tetratricopeptide repeat;
313-366 4.26e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 4.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 446542873  313 IALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYL 366
Cdd:pfam14559   8 LELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAAL 61
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
316-359 5.33e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 5.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446542873 316 LQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSS 359
Cdd:COG3063   48 LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 159-356 9.56e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 9.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  159 AKQQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQ-------ALGEWQPLLALLPKLVKAKR-LSNEEAQQLEITA 230
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAvmknyakAITSLKRALELKPDNTEAQIgLAQLLLAAKRTES 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446542873  231 QRGILQDIASQKGSEGLVQHwaqlsrklkaepellmcFITQLIQRKADY-EAFSMIKESLKKQATPELYALLPE-LNISD 308
Cdd:TIGR02917 688 AKKIAKSLQKQHPKAALGFE-----------------LEGDLYLRQKDYpAAIQAYRKALKRAPSSQNAIKLHRaLLASG 750

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 446542873  309 RHP-LIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSL 356
Cdd:TIGR02917 751 NTAeAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKK 799
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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