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Conserved domains on  [gi|446546144|ref|WP_000623490|]
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MULTISPECIES: glycosyltransferase family 2 protein [Enterobacteriaceae]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11440371)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  9445404|12691742

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-216 4.15e-18

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


:

Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 81.19  E-value: 4.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSKVETFISALLANTHGqknilkNIELIIIDDGSEvnleDTTIAFSEKFNERewRLVFLRNEINEGRAF 80
Cdd:COG1216    4 KVSVVIPTYNRPELLRRCLESLLAQTYP------PFEVIVVDNGST----DGTAELLAALAFP--RVRVIRNPENLGFAA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  81 SRNRAAKSASNEWLFFVDIDNLLQQGCLDSLhsmilscekpfVARANvrcrqdltrdsnylhyfdsrylgnrykgtvkie 160
Cdd:COG1216   72 ARNLGLRAAGGDYLLFLDDDTVVEPDWLERL-----------LAAAC--------------------------------- 107

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446546144 161 yryfasdaFLISKSEFEAQKGFDESFRHYGcEDEEFGARLRLSSVPFFFCSDALLY 216
Cdd:COG1216  108 --------LLIRREVFEEVGGFDERFFLYG-EDVDLCLRLRKAGYRIVYVPDAVVY 154
 
Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-216 4.15e-18

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 81.19  E-value: 4.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSKVETFISALLANTHGqknilkNIELIIIDDGSEvnleDTTIAFSEKFNERewRLVFLRNEINEGRAF 80
Cdd:COG1216    4 KVSVVIPTYNRPELLRRCLESLLAQTYP------PFEVIVVDNGST----DGTAELLAALAFP--RVRVIRNPENLGFAA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  81 SRNRAAKSASNEWLFFVDIDNLLQQGCLDSLhsmilscekpfVARANvrcrqdltrdsnylhyfdsrylgnrykgtvkie 160
Cdd:COG1216   72 ARNLGLRAAGGDYLLFLDDDTVVEPDWLERL-----------LAAAC--------------------------------- 107

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446546144 161 yryfasdaFLISKSEFEAQKGFDESFRHYGcEDEEFGARLRLSSVPFFFCSDALLY 216
Cdd:COG1216  108 --------LLIRREVFEEVGGFDERFFLYG-EDVDLCLRLRKAGYRIVYVPDAVVY 154
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-116 1.60e-15

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 72.92  E-value: 1.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   4 IISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEINEGRAFSRN 83
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTY------PNFEVIVVDDGST----DGTLEILEEYAKKDPRVIRVINEENQGLAAARN 70

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446546144  84 RAAKSASNEWLFFVDIDNLLQQGCLDSLHSMIL 116
Cdd:cd00761   71 AGLKAARGEYILFLDADDLLLPDWLERLVAELL 103
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-177 3.27e-12

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 63.57  E-value: 3.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144    3 SIISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEINEGRAFSR 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTY------PNFEIIVVDDGST----DGTVEIAEEYAKKDPRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   83 NRAAKSASNEWLFFVDIDNLLQQGCLDSLHSMILSCEKPFVARANVRCRQDLTRDSNYLHYFDSRYLGNRYKGTVKIEYR 162
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLP 150

                         170
                  ....*....|....*
gi 446546144  163 YFASDAFLISKSEFE 177
Cdd:pfam00535 151 FLIGGFALYRREALE 165
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-114 1.18e-07

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 52.36  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSKVETFISALLANThgqkniLKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEiNEGRAF 80
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLIAQT------WTALEIIIVNDGST----DNSVEIAKHYAENYPHVRLLHQA-NAGVSV 75

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446546144  81 SRNRAAKSASNEWLFFVDIDNLLQQGCLDSLHSM 114
Cdd:PRK10073  76 ARNTGLAVATGKYVAFPDADDVVYPTMYETLMTM 109
 
Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-216 4.15e-18

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 81.19  E-value: 4.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSKVETFISALLANTHGqknilkNIELIIIDDGSEvnleDTTIAFSEKFNERewRLVFLRNEINEGRAF 80
Cdd:COG1216    4 KVSVVIPTYNRPELLRRCLESLLAQTYP------PFEVIVVDNGST----DGTAELLAALAFP--RVRVIRNPENLGFAA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  81 SRNRAAKSASNEWLFFVDIDNLLQQGCLDSLhsmilscekpfVARANvrcrqdltrdsnylhyfdsrylgnrykgtvkie 160
Cdd:COG1216   72 ARNLGLRAAGGDYLLFLDDDTVVEPDWLERL-----------LAAAC--------------------------------- 107

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446546144 161 yryfasdaFLISKSEFEAQKGFDESFRHYGcEDEEFGARLRLSSVPFFFCSDALLY 216
Cdd:COG1216  108 --------LLIRREVFEEVGGFDERFFLYG-EDVDLCLRLRKAGYRIVYVPDAVVY 154
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-116 1.60e-15

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 72.92  E-value: 1.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   4 IISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEINEGRAFSRN 83
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTY------PNFEVIVVDDGST----DGTLEILEEYAKKDPRVIRVINEENQGLAAARN 70

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446546144  84 RAAKSASNEWLFFVDIDNLLQQGCLDSLHSMIL 116
Cdd:cd00761   71 AGLKAARGEYILFLDADDLLLPDWLERLVAELL 103
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-177 3.27e-12

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 63.57  E-value: 3.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144    3 SIISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEINEGRAFSR 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTY------PNFEIIVVDDGST----DGTVEIAEEYAKKDPRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   83 NRAAKSASNEWLFFVDIDNLLQQGCLDSLHSMILSCEKPFVARANVRCRQDLTRDSNYLHYFDSRYLGNRYKGTVKIEYR 162
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLP 150

                         170
                  ....*....|....*
gi 446546144  163 YFASDAFLISKSEFE 177
Cdd:pfam00535 151 FLIGGFALYRREALE 165
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-188 4.81e-12

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 64.34  E-value: 4.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEINEGRAF 80
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTY------PDFEIIVVDDGST----DGTAEILRELAAKDPRIRVIRLERNRGKGA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  81 SRNRAAKSASNEWLFFVDIDNLLQQGCLDSLHSMILSCEKPFV--ARANVRCRQDLTRDSNYLHYFDSRYLgnrykgtvk 158
Cdd:COG0463   73 ARNAGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVygSRLIREGESDLRRLGSRLFNLVRLLT--------- 143

                        170       180       190
                 ....*....|....*....|....*....|
gi 446546144 159 iEYRYFASDAFLISKSEFEAQkGFDESFRH 188
Cdd:COG0463  144 -NLPDSTSGFRLFRREVLEEL-GFDEGFLE 171
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 2-223 5.69e-12

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 65.15  E-value: 5.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   2 ISIISPVLGSSSKVETFISALLANTHGQKNIlkniELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEINEGRAFS 81
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSLLAQDYPKEKL----EVIVVDDGST----DETAEIARELAAEYPRVRVIERPENGGKAAA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  82 RNRAAKSASNEWLFFVDIDNLLQQGCLDSLhsmilscekpfvaranvrcrqdltrdsnyLHYFDSRYLGNRykGTvkiey 161
Cdd:COG1215  103 LNAGLKAARGDIVVFLDADTVLDPDWLRRL-----------------------------VAAFADPGVGAS--GA----- 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446546144 162 ryfasdAFLISKSEFEAQKGFDEsfrHYGCEDEEFGARLRLSSVPFFFCSDALLYDNDTPTL 223
Cdd:COG1215  147 ------NLAFRREALEEVGGFDE---DTLGEDLDLSLRLLRAGYRIVYVPDAVVYEEAPETL 199
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-203 1.25e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 53.33  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   4 IISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSEvnleDTTIAFSEKFNERewrLVFLRNEINEGRAFSRN 83
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTY------PDFEVIVVDNAST----DGSVELLRELFPE---VRLIRNGENLGFGAGNN 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  84 RAAKSASNEWLFFVDIDNLLQQGCLDSLHsmilsceKPFVARANVRCrqdltrdsnylhyfdsryLGNRYKGTvkieyry 163
Cdd:cd04186   68 QGIREAKGDYVLLLNPDTVVEPGALLELL-------DAAEQDPDVGI------------------VGPKVSGA------- 115

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446546144 164 fasdAFLISKSEFEAQKGFDESFRHYgCEDEEFGARLRLS 203
Cdd:cd04186  116 ----FLLVRREVFEEVGGFDEDFFLY-YEDVDLCLRARLA 150
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 35-196 3.88e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 53.06  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  35 NIELIIIDDGSEvnlEDTTIAFSEKFNEREWRLVFLRN--EINEGRAFSRNRAAKSASNEWLFFVDIDNLLQQGCLDSLH 112
Cdd:cd04192   28 KFEVILVDDHST---DGTVQILEFAAAKPNFQLKILNNsrVSISGKKNALTTAIKAAKGDWIVTTDADCVVPSNWLLTFV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144 113 SMILSCEKPFVARAnVRCRQDltrDS--NYLHYFDSRYLGNRYKGTVKIEYRYFASDA-FLISKSEFEAQKGFDESfRHY 189
Cdd:cd04192  105 AFIQKEQIGLVAGP-VIYFKG---KSllAKFQRLDWLSLLGLIAGSFGLGKPFMCNGAnMAYRKEAFFEVGGFEGN-DHI 179


                 ....*..
gi 446546144 190 GCEDEEF 196
Cdd:cd04192  180 ASGDDEL 186
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 2-201 5.33e-08

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 52.57  E-value: 5.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   2 ISIISPVLGSSSKVETFISALLANTHGqknilkNIELIIIDDGSEvnleDTTIAFSEKFNereWRLVflrnEINEGRAFS 81
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRRLNPL------PLEIIVVDGGST----DGTVAIARSAG---VVVI----SSPKGRARQ 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  82 RNRAAKSASNEWLFFVDIDNLLQQGcLDSLHSMILSCEKPFVARANVRCRQDLTRDSNYLH--YFDSRYLGNRYkGtvki 159
Cdd:cd02522   64 MNAGAAAARGDWLLFLHADTRLPPD-WDAAIIETLRADGAVAGAFRLRFDDPGPRLRLLELgaNLRSRLFGLPY-G---- 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446546144 160 eyryfasD-AFLISKSEFEAQKGFDESfrhYGCEDEEFGARLR 201
Cdd:cd02522  138 -------DqGLFIRRELFEELGGFPEL---PLMEDVELVRRLR 170
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 35-217 7.33e-08

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 52.66  E-value: 7.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   35 NIELIIIDDGSEvnlEDTTIAFSEKFNERewRLVFLRNEINE--GRAFSRNRAAKSASNEWLFFVDIDNLlqqGCLDSLH 112
Cdd:pfam10111  29 EFELIIINDGST---DKTLEEVSSIKDHN--LQVYYPNAPDTtySLAASRNRGTSHAIGEYISFIDGDCL---WSPDKFE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  113 SMiLSCEKPFVARANVRCRQDLT------RDSNYLHYFDSRYLGNRYKGTVKIEYRYFA------SDAFLISKSEFEAQK 180
Cdd:pfam10111 101 KQ-LKIATSLALQENIQAAVVLPvtdlndESSNFLRRGGDLTASGDVLRDLLVFYSPLAiffapnSSNALINRQAFIEVG 179

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 446546144  181 GFDESFRHYGCEDEEFGARLRLSSVPFFFCSDALLYD 217
Cdd:pfam10111 180 GFDESFRGHGAEDFDIFLRLAARYPFVAVMPPQLLYR 216
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 2-250 1.02e-07

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 52.23  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   2 ISIISPVLGSSSKVETFISALLANTHGQKNIlkniELIIIDDGSevnlEDTTIAFSEKFNEREWRLVFLRNEiNEGRAFS 81
Cdd:cd02525    2 VSIIIPVRNEEKYIEELLESLLNQSYPKDLI----EIIVVDGGS----TDGTREIVQEYAAKDPRIRLIDNP-KRIQSAG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  82 RNRAAKSASNEWLFFVD----IDNLLQQGCLDSLHS---------MILSCEKPFVARANVrcrqdltrdsNYLHYFdsrY 148
Cdd:cd02525   73 LNIGIRNSRGDIIIRVDahavYPKDYILELVEALKRtgadnvggpMETIGESKFQKAIAV----------AQSSPL---G 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144 149 LGNRYKGTVKIEYRYFASDAF-LISKSEFEAQKGFDESFRHygCEDEEFGARLRLSSVPFFFCSDALLYDNDTPTLDRAC 227
Cdd:cd02525  140 SGGSAYRGGAVKIGYVDTVHHgAYRREVFEKVGGFDESLVR--NEDAELNYRLRKAGYKIWLSPDIRVYYYPRSTLKKLA 217

                        250       260
                 ....*....|....*....|...
gi 446546144 228 ERMIPYARYsVPLLVKKHPEIVD 250
Cdd:cd02525  218 RQYFRYGKW-RARTLRKHRKSLS 239
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-114 1.18e-07

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 52.36  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSKVETFISALLANThgqkniLKNIELIIIDDGSEvnleDTTIAFSEKFNEREWRLVFLRNEiNEGRAF 80
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLIAQT------WTALEIIIVNDGST----DNSVEIAKHYAENYPHVRLLHQA-NAGVSV 75

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446546144  81 SRNRAAKSASNEWLFFVDIDNLLQQGCLDSLHSM 114
Cdd:PRK10073  76 ARNTGLAVATGKYVAFPDADDVVYPTMYETLMTM 109
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 19-108 1.37e-07

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 50.69  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  19 ISALLANTHGqknilkNIELIIIDDGSEvnlEDTTIAFSEKFNEREWRLVFLRNEINEGRAFSRNRAAKSASNEWLFFVD 98
Cdd:cd06423   16 IESLLALDYP------KLEVIVVDDGST---DDTLEILEELAALYIRRVLVVRDKENGGKAGALNAGLRHAKGDIVVVLD 86

                         90
                 ....*....|
gi 446546144  99 IDNLLQQGCL 108
Cdd:cd06423   87 ADTILEPDAL 96
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 37-200 1.97e-07

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 50.27  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  37 ELIIIDDGSEVNLEDTTIAFSEKFNereWRLVFLRNEiNEG--RAFSRNRAAKSASNEWLFFVDIDnllqqgcldslhsM 114
Cdd:cd06420   28 EVIIADDGSTEETKELIEEFKSQFP---IPIKHVWQE-DEGfrKAKIRNKAIAAAKGDYLIFIDGD-------------C 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144 115 ILscEKPFVARanvrcRQDLTRDSNYLHyfdsrylGNRYKGTVKIEYRYFASDAFLISKSEFEAQKGFDESFRHYGCEDE 194
Cdd:cd06420   91 IP--HPDFIAD-----HIELAEPGVFLS-------GSRVLLNEKLTERGIRGCNMSFWKKDLLAVNGFDEEFTGWGGEDS 156


                 ....*.
gi 446546144 195 EFGARL 200
Cdd:cd06420  157 ELVARL 162
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 3-209 8.53e-06

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 46.00  E-value: 8.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   3 SIISPVLGSSSKVETFISALLANTHgqknilKNIELIIIDDGSevnlEDTTIAFSEKFNErewRLVFLRNEINEGR--AF 80
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTY------PNIEYIVIDGGS----TDGTVDIIKKYED---KITYWISEPDKGIydAM 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  81 srNRAAKSASNEWLFFVDIDNLLQQGCLDSLHSMILSCEKP--FVARANVRCRQDLTRDSNYLHYFDSRYLgnrykgtvk 158
Cdd:cd06433   68 --NKGIALATGDIIGFLNSDDTLLPGALLAVVAAFAEHPEVdvVYGDVLLVDENGRVIGRRRPPPFLDKFL--------- 136

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446546144 159 IEYRYFASDAFLISKSEFEAQKGFDESFRHYGceDEEFGARLRLSSVPFFF 209
Cdd:cd06433  137 LYGMPICHQATFFRRSLFEKYGGFDESYRIAA--DYDLLLRLLLAGKIFKY 185
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 1-230 1.52e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 45.44  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144    1 MISIISPVLGSSSKVETFISALLANTHGqknilkNIELIIIDDGSEVNLEDTTIAFSEKFNEREWRLVFlRNEINEGRAF 80
Cdd:pfam13641   3 DVSVVVPAFNEDSVLGRVLEAILAQPYP------PVEVVVVVNPSDAETLDVAEEIAARFPDVRLRVIR-NARLLGPTGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   81 SR--NRAAKSASNEWLFFVDIDNLLQQGCLDSLHSmILSCEKPFVARANVRCRQD------LTRDSNYLHYFDsRYLGNR 152
Cdd:pfam13641  76 SRglNHGFRAVKSDLVVLHDDDSVLHPGTLKKYVQ-YFDSPKVGAVGTPVFSLNRstmlsaLGALEFALRHLR-MMSLRL 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446546144  153 YKGTVkieyrYFASDAFLISKSEFEAQKGFDESFrhYGCEDEEFGARLRLSSVPFFFCSDALLYDNDTPTLDRACERM 230
Cdd:pfam13641 154 ALGVL-----PLSGAGSAIRREVLKELGLFDPFF--LLGDDKSLGRRLRRHGWRVAYAPDAAVRTVFPTYLAASIKQR 224
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 37-143 3.03e-04

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 41.51  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  37 ELIIIDDGSEvnleDTTIAFSEKFNERewrlVFLRNEINEGRAfsRNRAAKSASNEWLFFVDIDNLLQQGCLDSLHSMIL 116
Cdd:cd02511   28 EIIVVDSGST----DRTVEIAKEYGAK----VYQRWWDGFGAQ--RNFALELATNDWVLSLDADERLTPELADEILALLA 97

                         90       100
                 ....*....|....*....|....*....
gi 446546144 117 SCEKP--FVARANVRCRQDLTRDSNYLHY 143
Cdd:cd02511   98 TDDYDgyYVPRRNFFLGRWIRHGGWYPDR 126
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 1-108 7.54e-04

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 39.88  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144   1 MISIISPVLGSSSK-VETFISALLANTHgqknilKNIELIIIDDGSEvnlEDTTIAFSEKFNEREWRLVFLRNEINEGRA 79
Cdd:cd04184    2 LISIVMPVYNTPEKyLREAIESVRAQTY------PNWELCIADDAST---DPEVKRVLKKYAAQDPRIKVVFREENGGIS 72

                         90       100
                 ....*....|....*....|....*....
gi 446546144  80 FSRNRAAKSASNEWLFFVDIDNLLQQGCL 108
Cdd:cd04184   73 AATNSALELATGEFVALLDHDDELAPHAL 101
Glyco_transf_7C pfam02709
N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of ...
 158-203 1.67e-03

N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 460659 [Multi-domain]  Cd Length: 78  Bit Score: 36.82  E-value: 1.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446546144  158 KIEYRYFASDAFLISKSEFEAQKGFDESFRHYGCEDEEFGARLRLS 203
Cdd:pfam02709  13 KLPYKTYFGGVLALSREDFERINGFSNGFWGWGGEDDDLYNRLLLA 58
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 29-101 8.30e-03

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 36.78  E-value: 8.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446546144  29 QKNILKNIELIIIDDGSEvnleDTTIAFSEKF-NEREWRLVFLRNEINEGRAFSRNRAAKSASNEWLFFVDIDN 101
Cdd:cd04188   24 EERPSFSYEIIVVDDGSK----DGTAEVARKLaRKNPALIRVLTLPKNRGKGGAVRAGMLAARGDYILFADADL 93
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 35-120 9.03e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 37.44  E-value: 9.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446546144  35 NIELIIIDDGSEVNLEDTTIAFSEKFNEREWRLVFLRNEINEGRAFSRNRAAKSASNEWLFFVDIDNLLQQGCLDSLHSM 114
Cdd:PTZ00260 107 KYEIIIVNDGSKDKTLKVAKDFWRQNINPNIDIRLLSLLRNKGKGGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDI 186


                 ....*.
gi 446546144 115 ILSCEK 120
Cdd:PTZ00260 187 MLKIEQ 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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