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Conserved domains on  [gi|446556407|ref|WP_000633753|]
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MULTISPECIES: GNAT family N-acetyltransferase [Bacillus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11450351)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
11-135 5.08e-26

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 95.25  E-value: 5.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407  11 ETYVLRQKILRPSQTLADCKYPSDYETDSFHLGAFINDKLISIASFskeIYPDLPTGihyRLRGMATLPEFRNNHAGSSL 90
Cdd:COG2153    6 DALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGELVATARL---LPPGDGEA---KIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446556407  91 IQKAEQILQERQANILWCNGRITVADYYKRLGFQEHGEIFEIEPI 135
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGI 124
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
11-135 5.08e-26

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 95.25  E-value: 5.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407  11 ETYVLRQKILRPSQTLADCKYPSDYETDSFHLGAFINDKLISIASFskeIYPDLPTGihyRLRGMATLPEFRNNHAGSSL 90
Cdd:COG2153    6 DALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGELVATARL---LPPGDGEA---KIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446556407  91 IQKAEQILQERQANILWCNGRITVADYYKRLGFQEHGEIFEIEPI 135
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGI 124
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 31-123 1.16e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407   31 YPSDYETDSFHLGAFINDKLISIASFskeiYPDLPTGIHYRLRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWCNG 110
Cdd:pfam00583  25 EDWDEDASEGFFVAEEDGELVGFASL----SIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEV 100

                          90
                  ....*....|....*.
gi 446556407  111 RIT---VADYYKRLGF 123
Cdd:pfam00583 101 AADnlaAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 41-109 1.73e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.64  E-value: 1.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446556407  41 HLGAFINDKLISIASfskeIYPDLPTGIHYRLRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWCN 109
Cdd:cd04301    1 FLVAEDDGEIVGFAS----LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
11-135 5.08e-26

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 95.25  E-value: 5.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407  11 ETYVLRQKILRPSQTLADCKYPSDYETDSFHLGAFINDKLISIASFskeIYPDLPTGihyRLRGMATLPEFRNNHAGSSL 90
Cdd:COG2153    6 DALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGELVATARL---LPPGDGEA---KIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446556407  91 IQKAEQILQERQANILWCNGRITVADYYKRLGFQEHGEIFEIEPI 135
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGI 124
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
31-145 2.38e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.09  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407  31 YPSDYETDSFH-----------LGAFINDKLISIASFSK-EIYPDLPTgihYRLRGMATLPEFRNNHAGSSLIQKAEQIL 98
Cdd:COG3153   20 FGPGREAELVDrlredpaaglsLVAEDDGEIVGHVALSPvDIDGEGPA---LLLGPLAVDPEYRGQGIGRALMRAALEAA 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446556407  99 QERQANILWCNGRITVADYYKRLGFQEHGEiFEIEPIGLHKVLYKRI 145
Cdd:COG3153   97 RERGARAVVLLGDPSLLPFYERFGFRPAGE-LGLTLGPDEVFLAKEL 142
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 36-141 8.60e-09

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 50.82  E-value: 8.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407  36 ETDSFHLGAFINDKLISIASFSKeiypdLPTGIHYrLRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWcngrITVA 115
Cdd:COG0454   31 LAGAEFIAVDDKGEPIGFAGLRR-----LDDKVLE-LKRLYVLPEYRGKGIGKALLEALLEWARERGCTALE----LDTL 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446556407 116 D-------YYKRLGFQEHGEIFEIEPIGLHKVL 141
Cdd:COG0454  101 DgnpaairFYERLGFKEIERYVAYVGGEFEKEL 133
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 31-123 1.16e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407   31 YPSDYETDSFHLGAFINDKLISIASFskeiYPDLPTGIHYRLRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWCNG 110
Cdd:pfam00583  25 EDWDEDASEGFFVAEEDGELVGFASL----SIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEV 100

                          90
                  ....*....|....*.
gi 446556407  111 RIT---VADYYKRLGF 123
Cdd:pfam00583 101 AADnlaAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 38-125 1.48e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407   38 DSFHLGAFINDKLISIASFSKEIYPDLPTGIHyrlrgMATLPEFRNNHAGSSLIQKAEQILQERQANILWCNGRITVADY 117
Cdd:pfam13508   2 GGRFFVAEDDGKIVGFAALLPLDDEGALAELR-----LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAF 76


                  ....*...
gi 446556407  118 YKRLGFQE 125
Cdd:pfam13508  77 YEKLGFEE 84
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 69-129 6.29e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 44.65  E-value: 6.29e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446556407  69 HYRLRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWCNGRI--TVA-DYYKRLGFQEHGEI 129
Cdd:COG0456   13 EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREdnEAAiALYEKLGFEEVGER 76
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 72-125 1.08e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 44.98  E-value: 1.08e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446556407  72 LRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWCNGRITVADYYKRLGFQE 125
Cdd:COG1246   55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFEE 108
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
49-132 3.72e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 42.59  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407  49 KLISIASFSkeiypdLPTGIHYRLRGMATLPEFRNNHAGSSLIQKAEQILQERQANI--LWCNGRITVA-DYYKRLGFQE 125
Cdd:COG3393    1 ELVAMAGVR------AESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTpfLYVDADNPAArRLYERLGFRP 74


                 ....*..
gi 446556407 126 HGEIFEI 132
Cdd:COG3393   75 VGEYATV 81
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 36-131 4.20e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 40.72  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446556407   36 ETDSFHLGAFINDKLISIASfskeiypdLPTGIHYRLrgMATLPEFRNNHAGSSLIQKAEQILQERQANIlwcnGRITV- 114
Cdd:pfam13673  28 QGEYFFFVAFEGGQIVGVIA--------LRDRGHISL--LFVDPDYQGQGIGKALLEAVEDYAEKDGIKL----SELTVn 93

                          90       100
                  ....*....|....*....|..
gi 446556407  115 -----ADYYKRLGFQEHGEIFE 131
Cdd:pfam13673  94 aspyaVPFYEKLGFRATGPEQE 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 41-109 1.73e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.64  E-value: 1.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446556407  41 HLGAFINDKLISIASfskeIYPDLPTGIHYRLRGMATLPEFRNNHAGSSLIQKAEQILQERQANILWCN 109
Cdd:cd04301    1 FLVAEDDGEIVGFAS----LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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