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Conserved domains on  [gi|446560040|ref|WP_000637386|]
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MULTISPECIES: type IV secretion system protein TraC [Gammaproteobacteria]

Protein Classification

TraC family protein( domain architecture ID 1002648)

TraC family protein similar to Thermoanaerobacter pseudethanolicus type IV secretory pathway Virb4 components-like protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TraC-F-type super family cl37161
type-IV secretion system protein TraC; The protein family described here is common among the F, ...
25-811 0e+00

type-IV secretion system protein TraC; The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.


The actual alignment was detected with superfamily member TIGR02746:

Pssm-ID: 274279 [Multi-domain]  Cd Length: 797  Bit Score: 611.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   25 PVLAYDEDDHVFlMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDINQEMYRMMGLRDGfRHE 104
Cdd:TIGR02746   3 PYRAYDEESGIF-MNRHSMGFGLELTPLSGADESLVESLSSLLRTDLPEGTDIQVLLWGSPQIGPFLDRNEEQFSQ-NGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  105 LLTSVIKERINFLQHhTTERIFAKTNkgiydNGLIQDLKLFVTCKVPIKNNNptESELQQLAQLRTKVESSLQTVGLRPR 184
Cdd:TIGR02746  81 ILEKLARNRVKYYLN-AAQKGFFKNS-----GVTLRDFRLFLSVSIPFKSPN--EDVIQELRSLRERIESTLRSAGFGCR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  185 TMTAVNYIRIMSTILNWGPDaSWRHDSVDWEMDKPICEQIFDYGTDVEVSKNGI--RLGDYHA------KVMSAKKLPD- 255
Cdd:TIGR02746 153 RVDAEDLLSLVREMLNPDPD-SIHPWPISYDPNQLLRDQIVDPDTDLEVHEGGLevDHEDNQGevktriRVFSIKRFPEe 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  256 --VFYFGDALtyaGDLSGGNSSIKENYMVVTNVFFPEAESTKNTLERKRQFTVNQAYGPMLKFVPVLADKKESFDTLYES 333
Cdd:TIGR02746 232 ftLWQTGNLI---GDLLNPSLQITCPFLLSFTVRVEDQVKKKAKATAKAKDLNKQAKSSMAKWVPSLEKKLKEIKYLREA 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  334 -MKEGAKPVKITYSVVLFApTKERVEAAAMAARNIWRESRFELMEDKFVALPMFLNCLPFCTDRDAVRDL---FRYKTMT 409
Cdd:TIGR02746 309 iASGGDSLVSMYYNVLLFT-NPDNLRRDVEAAKSSFRKNGFDLAEDKRIQLQAFLAALPFNPTEGLFEDLkkaGRVRTLS 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  410 TEQAAVVLPVFGEWKGTGTYHAALISRNGQLMSLSLHDSN-TNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAG 488
Cdd:TIGR02746 388 SANAVNLLPLIADWKGTKGSGLLLPTRRGQLSAFDPFDSDsTNYNIAVVGGSGAGKSFFMQELIVDNLSRGGKVWVIDVG 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  489 KSYQKLSEMLNGDFVHFEEGTHVCLNPF--ELIQNYEDEEDAIVSLVCAMASAKGLLDEWQISALKQVLSRLWEEKGKEM 566
Cdd:TIGR02746 468 RSYKKLCEMLGGTYIEFSPESNICLNPFtgNNVTEIDDEIDQITALIALMASPEGGLSDEQRSTLEEAILAAWKEYGNEA 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  567 KVDDIAERCLE---EENDQRLKDIGQQLYAFTSKGSYGKYFSRKNNVSFQNQFTVLELDELQGRKHLRQVVLLQLIYQIQ 643
Cdd:TIGR02746 548 TITDVQDALQQledDENDPRIKDLGKMLNPYTSHGVYGRYFNGPNNLDFSNRFVVLELEELEDRPDLQAVVLFSLMVRIT 627
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  644 QEVFLGERNRKKVVIVDEAWDLL--KEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENAVGRAIAENSASMYLLGQT 721
Cdd:TIGR02746 628 GEMYLTPRKRRKICIIDEAWSLLdgANPQAADFIETGYRRARKYGGAFITITQGIEDFYSSPEARAAYANSDWKIILRQS 707
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  722 EETVESVKRSGRLTLSEGGFHTLKTVHTIQGVYSEIFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAIDQFVKQGMSIP 801
Cdd:TIGR02746 708 AESIAKLKAENPFTFSPFEKRLIKSLRTAKGAFSELLIRSGEGSSVHRLFVDPFSRVLFSTDGPEFEEVEELREQGLSLE 787
                         810
                  ....*....|
gi 446560040  802 EAIKAVMRSR 811
Cdd:TIGR02746 788 EAIEQLAQKH 797
 
Name Accession Description Interval E-value
TraC-F-type TIGR02746
type-IV secretion system protein TraC; The protein family described here is common among the F, ...
25-811 0e+00

type-IV secretion system protein TraC; The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.


Pssm-ID: 274279 [Multi-domain]  Cd Length: 797  Bit Score: 611.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   25 PVLAYDEDDHVFlMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDINQEMYRMMGLRDGfRHE 104
Cdd:TIGR02746   3 PYRAYDEESGIF-MNRHSMGFGLELTPLSGADESLVESLSSLLRTDLPEGTDIQVLLWGSPQIGPFLDRNEEQFSQ-NGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  105 LLTSVIKERINFLQHhTTERIFAKTNkgiydNGLIQDLKLFVTCKVPIKNNNptESELQQLAQLRTKVESSLQTVGLRPR 184
Cdd:TIGR02746  81 ILEKLARNRVKYYLN-AAQKGFFKNS-----GVTLRDFRLFLSVSIPFKSPN--EDVIQELRSLRERIESTLRSAGFGCR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  185 TMTAVNYIRIMSTILNWGPDaSWRHDSVDWEMDKPICEQIFDYGTDVEVSKNGI--RLGDYHA------KVMSAKKLPD- 255
Cdd:TIGR02746 153 RVDAEDLLSLVREMLNPDPD-SIHPWPISYDPNQLLRDQIVDPDTDLEVHEGGLevDHEDNQGevktriRVFSIKRFPEe 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  256 --VFYFGDALtyaGDLSGGNSSIKENYMVVTNVFFPEAESTKNTLERKRQFTVNQAYGPMLKFVPVLADKKESFDTLYES 333
Cdd:TIGR02746 232 ftLWQTGNLI---GDLLNPSLQITCPFLLSFTVRVEDQVKKKAKATAKAKDLNKQAKSSMAKWVPSLEKKLKEIKYLREA 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  334 -MKEGAKPVKITYSVVLFApTKERVEAAAMAARNIWRESRFELMEDKFVALPMFLNCLPFCTDRDAVRDL---FRYKTMT 409
Cdd:TIGR02746 309 iASGGDSLVSMYYNVLLFT-NPDNLRRDVEAAKSSFRKNGFDLAEDKRIQLQAFLAALPFNPTEGLFEDLkkaGRVRTLS 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  410 TEQAAVVLPVFGEWKGTGTYHAALISRNGQLMSLSLHDSN-TNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAG 488
Cdd:TIGR02746 388 SANAVNLLPLIADWKGTKGSGLLLPTRRGQLSAFDPFDSDsTNYNIAVVGGSGAGKSFFMQELIVDNLSRGGKVWVIDVG 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  489 KSYQKLSEMLNGDFVHFEEGTHVCLNPF--ELIQNYEDEEDAIVSLVCAMASAKGLLDEWQISALKQVLSRLWEEKGKEM 566
Cdd:TIGR02746 468 RSYKKLCEMLGGTYIEFSPESNICLNPFtgNNVTEIDDEIDQITALIALMASPEGGLSDEQRSTLEEAILAAWKEYGNEA 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  567 KVDDIAERCLE---EENDQRLKDIGQQLYAFTSKGSYGKYFSRKNNVSFQNQFTVLELDELQGRKHLRQVVLLQLIYQIQ 643
Cdd:TIGR02746 548 TITDVQDALQQledDENDPRIKDLGKMLNPYTSHGVYGRYFNGPNNLDFSNRFVVLELEELEDRPDLQAVVLFSLMVRIT 627
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  644 QEVFLGERNRKKVVIVDEAWDLL--KEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENAVGRAIAENSASMYLLGQT 721
Cdd:TIGR02746 628 GEMYLTPRKRRKICIIDEAWSLLdgANPQAADFIETGYRRARKYGGAFITITQGIEDFYSSPEARAAYANSDWKIILRQS 707
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  722 EETVESVKRSGRLTLSEGGFHTLKTVHTIQGVYSEIFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAIDQFVKQGMSIP 801
Cdd:TIGR02746 708 AESIAKLKAENPFTFSPFEKRLIKSLRTAKGAFSELLIRSGEGSSVHRLFVDPFSRVLFSTDGPEFEEVEELREQGLSLE 787
                         810
                  ....*....|
gi 446560040  802 EAIKAVMRSR 811
Cdd:TIGR02746 788 EAIEQLAQKH 797
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
238-797 3.85e-118

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 368.12  E-value: 3.85e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 238 IRLGDYHAKVMSAKKLPDVFYFG--DALTyagdlsggnsSIKENYMVVTNVFFPEAESTKNTLERKRQFTVNQAYGPMLK 315
Cdd:COG3451    3 LEIGDRYGRVLSIKGYPSETSPGllDPLL----------QLPCEFIVTQSFTPLDKDEALKKLKRKRRRLESKRKSEQAL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 316 FVPVLADKKESFDTLYESMKEG-AKPVKITYSVVLFAPTKERVEAAAMAARNIWRESRFELMEDKFVALPMFLNCLPFCT 394
Cdd:COG3451   73 VDDDAESQAEDAEEALDELQSGgERLGEVHLTLTVFADDLEELEEAVREVESALQSAGFTLVRETLNQEEAFLSSLPGNF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 395 DRDavrdlFRYKTMTTEQAAVVLPVFGEWKGTGTYHAALISRNGQLMSLSLHDSNTNKNLVIAAESGSGKSFLTNELIFS 474
Cdd:COG3451  153 DYR-----LRRRLLTTSNLAALFPFHSFELGDPWGIYLLNTRSGTPVFFDFHDGLDNGNTLILGPSGSGKSFLLKLLLLQ 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 475 YLSEGAQVWVIDAGKSYQKLSEMLNGDFVHFEEGTHVCLNPFELIqNYEDEEDAIVSLVCAMASA-KGLLDEWQISALKQ 553
Cdd:COG3451  228 LLRYGARIVIFDPGGSYEILVRALGGTYIDLSPGSPTGLNPFDLE-DTEEKRDFLLELLELLLGReGEPLTPEERAAIDR 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 554 VLSRLWEEKGKEMK--VDDIAERCleeENDQRLKDIGQQLYAFTSKGSYGKYFSRKNNVSFQ-NQFTVLELDELQGRKHL 630
Cdd:COG3451  307 AVRALYRRADPEERttLSDLYELL---KEQPEAKDLAARLEPYTKGGSYGWLFDGPTNLDLSdARFVVFDLTELLDNPEL 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 631 RQVVLLQLIYQIQQEVFLGERNRKKVVIVDEAWDLLKEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENAVGRAIAE 710
Cdd:COG3451  384 RPPVLLYLLHRIWNRLRKNNDGRPTLIVIDEAWLLLDNPAFAEFLEEWLKTLRKYNGAVIFATQSVEDFLSSPIAEAIIE 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 711 NSASMYLLGQTEETVESVKRsgRLTLSEGGFHTLKTVHTIQGVYseiFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAI 790
Cdd:COG3451  464 NSATKILLPQPKADIEDYAE--LLGLSERELELIRSAGRGKRDF---LIKQGNGSVVFRLDLSPEELALLSTKPEEVAIL 538

                 ....*..
gi 446560040 791 DQFVKQG 797
Cdd:COG3451  539 DELRAEH 545
PRK13721 PRK13721
conjugal transfer ATP-binding protein TraC; Provisional
9-804 2.15e-74

conjugal transfer ATP-binding protein TraC; Provisional


Pssm-ID: 237480 [Multi-domain]  Cd Length: 844  Bit Score: 259.27  E-value: 2.15e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   9 LEETLIPEHLRaagIIPVLAYDEDDHVFlMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDIN 88
Cdd:PRK13721   2 LGEMSFPQFSR---LLPYRDYDQESGLF-MNDTTMGFMLEAIPLNGANESIVEALDHMLRTKLPRGIPLCIHLMSSKLVG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  89 QEMYRmmGLRD----GFRHELLTSVIKErinfLQHHTTERIFAKTNKGIYDNGLiQDLKLFVTCKVPIKNNnpTESELQQ 164
Cdd:PRK13721  78 DRIEY--GLREfswsGEQAERFNAITRA----YYMRAALTQFPLPEGMNLPLTL-RHYRVFISYCSPSKKK--SRADILE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 165 LAQLRTKVESSLQTVGLRPRTMTAVNYIRIMSTILNWGPDASWRHDSvDWEMDKPICEQIFDYGTDVEVSKNGIRLG--- 241
Cdd:PRK13721 149 MENLVKIIRASLQGASITTQTVDAQAFISIVREMINHRPDSLYPKRR-QLDPYSDLNYQCVEDSFDLKVRADYLTLGlre 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 242 ---DYHAKVMS--AKKLPDVFYfgdaLTYAGDlsggnssikeNYmvvTNVFFPE---------------AESTKNTLERK 301
Cdd:PRK13721 228 ngrNSTARILNfhLAKNPEIAF----LWQMAD----------NY---SNLLNPElsiscpfiltltlevEDQVKTQSEAN 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 302 RQFT-----VNQAYGpmlKFVPVLADKKESFDTLYESMKEGAKP-VKITYSVVLFAP-TKERVEAAAMAARNIWRESRFE 374
Cdd:PRK13721 291 LKYMdlekkSKTSYA---KWFPSVEKEAKEWGELRQRLGSNQSSlVSYFLNITAFCPdNNETALEVEQDILNSFRKNGFE 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 375 LMEDKFVALPMFLNCLPFCTDRDAVRDLfryKTM------TTEQAAVVLPVFGEWKGTGTYHAALISRNgQLMSLSLHD- 447
Cdd:PRK13721 368 LISPRFNHMRNFLTCLPFMAGEGLFKDL---KEAgvvqraESFNVANLMPLVADNPLTPAGLLAPTYRN-QLAFIDIFFr 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 448 --SNTNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAGKSYQKLSEMLNGDFVhfeEGTHVCLNPFELIQNYEDE 525
Cdd:PRK13721 444 gmNNTNYNMAVCGTSGAGKTGLIQPLIRSVLDSGGFAVVFDMGDGYKSLCENMGGVYL---DGETLRFNPFANITDIDQS 520
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 526 EDAIVSLVCAMASAKGLLDEWQISALKQVLSRLWEEKGKEMKVDDIA-----ERCLEEENDQ-----RLKDIGQQLYAFT 595
Cdd:PRK13721 521 AERIRDQLSVMASPNGNLDEVHEGLLLQAVRASWLAKKNRARIDDVVdflknARDSEQYADSptirsRLDEMIVLLDQYT 600
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 596 SKGSYGKYF-SRKNNVSFQNQFTVLELDELQGRKHLRQVVLLQLIYQIQQEVFLGERNRKKVVIVDEAWDLL--KEGEVS 672
Cdd:PRK13721 601 ANGTYGEYFnSDEPSLRDDARMVVLELGGLEDRPSLLVAVMFSLIIYIENRMYRTPRNLKKLNVIDEGWRLLdfKNHKVG 680
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 673 VFMEHAYRKFRKYGGSVVIATQSINDL---YENAVGRAIAENSASMYLLGQTEETVESVKRSGRLTLSE------GGFHT 743
Cdd:PRK13721 681 EFIEKGYRTARRHTGAYITITQNIVDFdsdKASSAARAAWGNSSYKIILKQSAKEFAKYNQLYPDQFSPlerdmiGGFGA 760
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446560040 744 LKTVHtiqgvYSEIFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAIDQFVKQGMSIPEAI 804
Cdd:PRK13721 761 AKDQW-----FSSFLLQVENHSSWHRLFVDPLSRAMYSSDGPDFEFVQQKRKEGLSIHEAV 816
TraC_F_IV pfam11130
TraC protein; This family of TraC proteins is conserved in Proteobacteria. TraC is a ...
19-255 2.33e-73

TraC protein; This family of TraC proteins is conserved in Proteobacteria. TraC is a cytoplasmic, peripheral membrane protein and is one of the proteins encoded by the F transfer region of the conjugative plasmid that is required for the assembly of F pilin into the mature F pilus structure. F pili are filamentous appendages that help establish the physical contact between donor and recipient cells involved in the conjugation process.


Pssm-ID: 431669 [Multi-domain]  Cd Length: 232  Bit Score: 239.11  E-value: 2.33e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   19 RAAGIIPVLAYDEDDHVFLMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDINQEMYRMMGLR 98
Cdd:pfam11130   2 SFSDLLPYVAYDPETGLFLNEDGSVGFVFELSPLGGADESVRDTLESLLSDDLPDGTPVQFLLFASPDIGPYLDRLRDYR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   99 DGFRHELLTSVIKERINFLQHHTTERIFAktnkgiYDNGLIQDLKLFVTCKVPIKNNNPTesELQQLAQLRTKVESSLQT 178
Cdd:pfam11130  82 LGEQGGHLRAIARPRGLFLDSGVTGSLSA------DWRGQLRRFRLVLSRKVPGKADLPT--PIEALNELRDRLEASLRS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  179 VGLRPRTMTAVNYIRIMSTILNWGPDASWRHDSvDWEMDKPICEQIFDYGTDVEVSKNGIRLGD---YHAKVMSAKKLPD 255
Cdd:pfam11130 154 AGLAARRLDPDDLIAWLRRWLNPDPSASWDPPA-DYDPDKDIAEQILDSDPRLDVEAGRLYFDGephRAVRVLSLRRFPE 232
TrwB_TraG_TraD_VirD4 cd01127
TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins; The TraG/TraD/VirD4 family are ...
630-720 1.27e-08

TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins; The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion (T4S) systems, versatile bacterial secretion systems mediating transport of protein and/or DNA. They are present in gram-negative and gram-positive bacteria, as well as archaea. They form hexameric rings and belong to the RecA-like NTPases superfamily, which also includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases.


Pssm-ID: 410871 [Multi-domain]  Cd Length: 144  Bit Score: 54.53  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 630 LRQVVLLQLIYQIQQEVFL--GERNRKKVVIVDEAWDLLKegevSVFMEHAYRKFRKYGGSVVIATQSINDLYENAV--- 704
Cdd:cd01127   53 LRALFFNQLFRALTELASLspGRLPRRVWFILDEFANLGR----IPNLPNLLATGRKRGISVVLILQSLAQLEAVYGkdg 128
                         90
                 ....*....|....*.
gi 446560040 705 GRAIAENSASMYLLGQ 720
Cdd:cd01127  129 AQTILGNCNTKLYLGT 144
 
Name Accession Description Interval E-value
TraC-F-type TIGR02746
type-IV secretion system protein TraC; The protein family described here is common among the F, ...
25-811 0e+00

type-IV secretion system protein TraC; The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.


Pssm-ID: 274279 [Multi-domain]  Cd Length: 797  Bit Score: 611.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   25 PVLAYDEDDHVFlMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDINQEMYRMMGLRDGfRHE 104
Cdd:TIGR02746   3 PYRAYDEESGIF-MNRHSMGFGLELTPLSGADESLVESLSSLLRTDLPEGTDIQVLLWGSPQIGPFLDRNEEQFSQ-NGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  105 LLTSVIKERINFLQHhTTERIFAKTNkgiydNGLIQDLKLFVTCKVPIKNNNptESELQQLAQLRTKVESSLQTVGLRPR 184
Cdd:TIGR02746  81 ILEKLARNRVKYYLN-AAQKGFFKNS-----GVTLRDFRLFLSVSIPFKSPN--EDVIQELRSLRERIESTLRSAGFGCR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  185 TMTAVNYIRIMSTILNWGPDaSWRHDSVDWEMDKPICEQIFDYGTDVEVSKNGI--RLGDYHA------KVMSAKKLPD- 255
Cdd:TIGR02746 153 RVDAEDLLSLVREMLNPDPD-SIHPWPISYDPNQLLRDQIVDPDTDLEVHEGGLevDHEDNQGevktriRVFSIKRFPEe 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  256 --VFYFGDALtyaGDLSGGNSSIKENYMVVTNVFFPEAESTKNTLERKRQFTVNQAYGPMLKFVPVLADKKESFDTLYES 333
Cdd:TIGR02746 232 ftLWQTGNLI---GDLLNPSLQITCPFLLSFTVRVEDQVKKKAKATAKAKDLNKQAKSSMAKWVPSLEKKLKEIKYLREA 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  334 -MKEGAKPVKITYSVVLFApTKERVEAAAMAARNIWRESRFELMEDKFVALPMFLNCLPFCTDRDAVRDL---FRYKTMT 409
Cdd:TIGR02746 309 iASGGDSLVSMYYNVLLFT-NPDNLRRDVEAAKSSFRKNGFDLAEDKRIQLQAFLAALPFNPTEGLFEDLkkaGRVRTLS 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  410 TEQAAVVLPVFGEWKGTGTYHAALISRNGQLMSLSLHDSN-TNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAG 488
Cdd:TIGR02746 388 SANAVNLLPLIADWKGTKGSGLLLPTRRGQLSAFDPFDSDsTNYNIAVVGGSGAGKSFFMQELIVDNLSRGGKVWVIDVG 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  489 KSYQKLSEMLNGDFVHFEEGTHVCLNPF--ELIQNYEDEEDAIVSLVCAMASAKGLLDEWQISALKQVLSRLWEEKGKEM 566
Cdd:TIGR02746 468 RSYKKLCEMLGGTYIEFSPESNICLNPFtgNNVTEIDDEIDQITALIALMASPEGGLSDEQRSTLEEAILAAWKEYGNEA 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  567 KVDDIAERCLE---EENDQRLKDIGQQLYAFTSKGSYGKYFSRKNNVSFQNQFTVLELDELQGRKHLRQVVLLQLIYQIQ 643
Cdd:TIGR02746 548 TITDVQDALQQledDENDPRIKDLGKMLNPYTSHGVYGRYFNGPNNLDFSNRFVVLELEELEDRPDLQAVVLFSLMVRIT 627
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  644 QEVFLGERNRKKVVIVDEAWDLL--KEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENAVGRAIAENSASMYLLGQT 721
Cdd:TIGR02746 628 GEMYLTPRKRRKICIIDEAWSLLdgANPQAADFIETGYRRARKYGGAFITITQGIEDFYSSPEARAAYANSDWKIILRQS 707
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  722 EETVESVKRSGRLTLSEGGFHTLKTVHTIQGVYSEIFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAIDQFVKQGMSIP 801
Cdd:TIGR02746 708 AESIAKLKAENPFTFSPFEKRLIKSLRTAKGAFSELLIRSGEGSSVHRLFVDPFSRVLFSTDGPEFEEVEELREQGLSLE 787
                         810
                  ....*....|
gi 446560040  802 EAIKAVMRSR 811
Cdd:TIGR02746 788 EAIEQLAQKH 797
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
238-797 3.85e-118

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 368.12  E-value: 3.85e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 238 IRLGDYHAKVMSAKKLPDVFYFG--DALTyagdlsggnsSIKENYMVVTNVFFPEAESTKNTLERKRQFTVNQAYGPMLK 315
Cdd:COG3451    3 LEIGDRYGRVLSIKGYPSETSPGllDPLL----------QLPCEFIVTQSFTPLDKDEALKKLKRKRRRLESKRKSEQAL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 316 FVPVLADKKESFDTLYESMKEG-AKPVKITYSVVLFAPTKERVEAAAMAARNIWRESRFELMEDKFVALPMFLNCLPFCT 394
Cdd:COG3451   73 VDDDAESQAEDAEEALDELQSGgERLGEVHLTLTVFADDLEELEEAVREVESALQSAGFTLVRETLNQEEAFLSSLPGNF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 395 DRDavrdlFRYKTMTTEQAAVVLPVFGEWKGTGTYHAALISRNGQLMSLSLHDSNTNKNLVIAAESGSGKSFLTNELIFS 474
Cdd:COG3451  153 DYR-----LRRRLLTTSNLAALFPFHSFELGDPWGIYLLNTRSGTPVFFDFHDGLDNGNTLILGPSGSGKSFLLKLLLLQ 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 475 YLSEGAQVWVIDAGKSYQKLSEMLNGDFVHFEEGTHVCLNPFELIqNYEDEEDAIVSLVCAMASA-KGLLDEWQISALKQ 553
Cdd:COG3451  228 LLRYGARIVIFDPGGSYEILVRALGGTYIDLSPGSPTGLNPFDLE-DTEEKRDFLLELLELLLGReGEPLTPEERAAIDR 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 554 VLSRLWEEKGKEMK--VDDIAERCleeENDQRLKDIGQQLYAFTSKGSYGKYFSRKNNVSFQ-NQFTVLELDELQGRKHL 630
Cdd:COG3451  307 AVRALYRRADPEERttLSDLYELL---KEQPEAKDLAARLEPYTKGGSYGWLFDGPTNLDLSdARFVVFDLTELLDNPEL 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 631 RQVVLLQLIYQIQQEVFLGERNRKKVVIVDEAWDLLKEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENAVGRAIAE 710
Cdd:COG3451  384 RPPVLLYLLHRIWNRLRKNNDGRPTLIVIDEAWLLLDNPAFAEFLEEWLKTLRKYNGAVIFATQSVEDFLSSPIAEAIIE 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 711 NSASMYLLGQTEETVESVKRsgRLTLSEGGFHTLKTVHTIQGVYseiFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAI 790
Cdd:COG3451  464 NSATKILLPQPKADIEDYAE--LLGLSERELELIRSAGRGKRDF---LIKQGNGSVVFRLDLSPEELALLSTKPEEVAIL 538

                 ....*..
gi 446560040 791 DQFVKQG 797
Cdd:COG3451  539 DELRAEH 545
PRK13721 PRK13721
conjugal transfer ATP-binding protein TraC; Provisional
9-804 2.15e-74

conjugal transfer ATP-binding protein TraC; Provisional


Pssm-ID: 237480 [Multi-domain]  Cd Length: 844  Bit Score: 259.27  E-value: 2.15e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   9 LEETLIPEHLRaagIIPVLAYDEDDHVFlMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDIN 88
Cdd:PRK13721   2 LGEMSFPQFSR---LLPYRDYDQESGLF-MNDTTMGFMLEAIPLNGANESIVEALDHMLRTKLPRGIPLCIHLMSSKLVG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  89 QEMYRmmGLRD----GFRHELLTSVIKErinfLQHHTTERIFAKTNKGIYDNGLiQDLKLFVTCKVPIKNNnpTESELQQ 164
Cdd:PRK13721  78 DRIEY--GLREfswsGEQAERFNAITRA----YYMRAALTQFPLPEGMNLPLTL-RHYRVFISYCSPSKKK--SRADILE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 165 LAQLRTKVESSLQTVGLRPRTMTAVNYIRIMSTILNWGPDASWRHDSvDWEMDKPICEQIFDYGTDVEVSKNGIRLG--- 241
Cdd:PRK13721 149 MENLVKIIRASLQGASITTQTVDAQAFISIVREMINHRPDSLYPKRR-QLDPYSDLNYQCVEDSFDLKVRADYLTLGlre 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 242 ---DYHAKVMS--AKKLPDVFYfgdaLTYAGDlsggnssikeNYmvvTNVFFPE---------------AESTKNTLERK 301
Cdd:PRK13721 228 ngrNSTARILNfhLAKNPEIAF----LWQMAD----------NY---SNLLNPElsiscpfiltltlevEDQVKTQSEAN 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 302 RQFT-----VNQAYGpmlKFVPVLADKKESFDTLYESMKEGAKP-VKITYSVVLFAP-TKERVEAAAMAARNIWRESRFE 374
Cdd:PRK13721 291 LKYMdlekkSKTSYA---KWFPSVEKEAKEWGELRQRLGSNQSSlVSYFLNITAFCPdNNETALEVEQDILNSFRKNGFE 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 375 LMEDKFVALPMFLNCLPFCTDRDAVRDLfryKTM------TTEQAAVVLPVFGEWKGTGTYHAALISRNgQLMSLSLHD- 447
Cdd:PRK13721 368 LISPRFNHMRNFLTCLPFMAGEGLFKDL---KEAgvvqraESFNVANLMPLVADNPLTPAGLLAPTYRN-QLAFIDIFFr 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 448 --SNTNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAGKSYQKLSEMLNGDFVhfeEGTHVCLNPFELIQNYEDE 525
Cdd:PRK13721 444 gmNNTNYNMAVCGTSGAGKTGLIQPLIRSVLDSGGFAVVFDMGDGYKSLCENMGGVYL---DGETLRFNPFANITDIDQS 520
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 526 EDAIVSLVCAMASAKGLLDEWQISALKQVLSRLWEEKGKEMKVDDIA-----ERCLEEENDQ-----RLKDIGQQLYAFT 595
Cdd:PRK13721 521 AERIRDQLSVMASPNGNLDEVHEGLLLQAVRASWLAKKNRARIDDVVdflknARDSEQYADSptirsRLDEMIVLLDQYT 600
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 596 SKGSYGKYF-SRKNNVSFQNQFTVLELDELQGRKHLRQVVLLQLIYQIQQEVFLGERNRKKVVIVDEAWDLL--KEGEVS 672
Cdd:PRK13721 601 ANGTYGEYFnSDEPSLRDDARMVVLELGGLEDRPSLLVAVMFSLIIYIENRMYRTPRNLKKLNVIDEGWRLLdfKNHKVG 680
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 673 VFMEHAYRKFRKYGGSVVIATQSINDL---YENAVGRAIAENSASMYLLGQTEETVESVKRSGRLTLSE------GGFHT 743
Cdd:PRK13721 681 EFIEKGYRTARRHTGAYITITQNIVDFdsdKASSAARAAWGNSSYKIILKQSAKEFAKYNQLYPDQFSPlerdmiGGFGA 760
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446560040 744 LKTVHtiqgvYSEIFIKSKSGMGVGRLIVGDFQKLLYSTDPVDVNAIDQFVKQGMSIPEAI 804
Cdd:PRK13721 761 AKDQW-----FSSFLLQVENHSSWHRLFVDPLSRAMYSSDGPDFEFVQQKRKEGLSIHEAV 816
TraC_F_IV pfam11130
TraC protein; This family of TraC proteins is conserved in Proteobacteria. TraC is a ...
19-255 2.33e-73

TraC protein; This family of TraC proteins is conserved in Proteobacteria. TraC is a cytoplasmic, peripheral membrane protein and is one of the proteins encoded by the F transfer region of the conjugative plasmid that is required for the assembly of F pilin into the mature F pilus structure. F pili are filamentous appendages that help establish the physical contact between donor and recipient cells involved in the conjugation process.


Pssm-ID: 431669 [Multi-domain]  Cd Length: 232  Bit Score: 239.11  E-value: 2.33e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   19 RAAGIIPVLAYDEDDHVFLMDDHSAGFGFMCEPLCGADEKVQERMNGFLNQEFPSKTTLQFVLFRSPDINQEMYRMMGLR 98
Cdd:pfam11130   2 SFSDLLPYVAYDPETGLFLNEDGSVGFVFELSPLGGADESVRDTLESLLSDDLPDGTPVQFLLFASPDIGPYLDRLRDYR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040   99 DGFRHELLTSVIKERINFLQHHTTERIFAktnkgiYDNGLIQDLKLFVTCKVPIKNNNPTesELQQLAQLRTKVESSLQT 178
Cdd:pfam11130  82 LGEQGGHLRAIARPRGLFLDSGVTGSLSA------DWRGQLRRFRLVLSRKVPGKADLPT--PIEALNELRDRLEASLRS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  179 VGLRPRTMTAVNYIRIMSTILNWGPDASWRHDSvDWEMDKPICEQIFDYGTDVEVSKNGIRLGD---YHAKVMSAKKLPD 255
Cdd:pfam11130 154 AGLAARRLDPDDLIAWLRRWLNPDPSASWDPPA-DYDPDKDIAEQILDSDPRLDVEAGRLYFDGephRAVRVLSLRRFPE 232
VirB4_CagE TIGR00929
type IV secretion/conjugal transfer ATPase, VirB4 family; Type IV secretion systems are found ...
279-795 1.39e-29

type IV secretion/conjugal transfer ATPase, VirB4 family; Type IV secretion systems are found in Gram-negative pathogens. They export proteins, DNA, or complexes in different systems and are related to plasmid conjugation systems. This model represents related ATPases that include VirB4 in Agrobacterium tumefaciens (DNA export) CagE in Helicobacter pylori (protein export) and plasmid TraB (conjugation).


Pssm-ID: 273346 [Multi-domain]  Cd Length: 785  Bit Score: 125.89  E-value: 1.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  279 NYMVVTNVFFPEAESTKNTLERKRQFTVNQAYGPMLkFVPVLADKKESFDTLYESMKEGAKpvkitySVVLFAPTKERVE 358
Cdd:TIGR00929 266 EFILTHSFSFLSKEAALSKLGRKRKRLISKGDRAKS-QIAELDEALDELTSGDFVMGEHHL------SLVVYAEDLEKLD 338
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  359 AAAMAARNIWRESRFELMEDKFVALPMFLNCLPfctdrDAVRDLFRYKTMTTEQAAVVLPVFGEWKGT------GTYHAA 432
Cdd:TIGR00929 339 AALREARSLLNACGIVAVIETLGLEAAFWSQLP-----GNFSWNPRKSLITSRNFASLIPFHNFNLGKlrgnpwGPALTL 413
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  433 LISRNGQLMSLSLH--DSNTNKNLVIAAESGSGKSFLTNELIFSYL-SEGAQVWVIDAGKSYQKLSEMLNGDFVHFEEGT 509
Cdd:TIGR00929 414 LKTQSGTPFYFNFHvrDAKVLGHTLIFGPTGSGKTTLLNFLLAQMQkYGGMTIFAFDKDRGMEIFIRAFGGAYLEIKDGE 493
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  510 HVCLNPFELIQNyEDEEDAIVSLVCAMASAKG--LLDEWQISALKQVLSRLWEEKgkeMKVDDIAErcLEEENDQRLKDI 587
Cdd:TIGR00929 494 PFGFNPFQLEDT-ERNRAFLKEWLAMLVTLDGstDISAEDRNALSSAIDTVYREG---PLIRSLSD--LLNFLPKDYIDL 567
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  588 GQQLYAFTSKGSYGKYF-SRKNNVSFqNQFTVLELDELQGRKHLRQVVLLQLIYQIQQEVflgeRNRKKVVIVDEAWDLL 666
Cdd:TIGR00929 568 ADRLEPWLKGGDYGWLFdNPTDDLDL-SKITGFDLTELLDNPKVATPVLMYLFHRINEAL----DGRPFLIIIDEAWQYL 642
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  667 KEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENAVGRAIAENSASMYLLGQTEETVESVKRSGRLTLSEggFHTLKT 746
Cdd:TIGR00929 643 GNPVFAAKIRDWLKTLRKANGIVVLATQSINDALGSRIADSILEQCATKIFLPNPEADREDYAEGFKLTERE--FELLKS 720
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446560040  747 VhtiqGVYSEIF-IKSKSGMGVGRLIVGDFQKLL--YSTDPVDVNAIDQFVK 795
Cdd:TIGR00929 721 T----PEESRKFlIKQGQSSVVAELNLGGMDNYLrvLSSDTENVEIIDALIK 768
Bac_Flav_CT_G TIGR03783
Bacteroides conjugation system ATPase, TraG family; Members of this family include the ...
450-720 8.02e-22

Bacteroides conjugation system ATPase, TraG family; Members of this family include the predicted ATPase, TraG, encoded by transfer region genes of conjugative transposons of Bacteroides, such as CTnDOT, found on the main chromosome. Members also include TraG homologs borne on plasmids in Bacteroides. The protein family is related to the conjugative transfer system ATPase VirB4. [Cellular processes, DNA transformation]


Pssm-ID: 163495 [Multi-domain]  Cd Length: 829  Bit Score: 101.45  E-value: 8.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  450 TNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAGKSYQKLSEMLN-------GDFVHFEEGTHVCLNPFELIQNY 522
Cdd:TIGR03783 437 TNRNKFILGPSGSGKSFFTNHLVRQYYEQGTHILLVDTGNSYQGLCELIHrktrgedGIYFTYTEENPIAFNPFYTDDGV 516
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  523 EDEE--DAIVSLVCAM---------ASAKGLLDewqiSALKQVLSRLWEEKGKEMKVDDIAE------RCLEEENDQRLK 585
Cdd:TIGR03783 517 FDVEkrESIKTLILTLwkredepptRSEEVALS----NAVSAYIRLISEDRGIAPSFNTFYEyvkddyRAELEEKKVREK 592
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  586 DIG-----QQLYAFTSKGSYGKYFSRKNNVSFQNQ-FTVLELDELQGRKHLRQVVLLqliyqIQQEVFLGERNR----KK 655
Cdd:TIGR03783 593 DFDidnflNVLEPYYKGGEYDFLLNSDKQLDLLHKrFIVFEIDAIKDNKILFPVVTI-----IIMEAFINKMRRlkgvRK 667
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446560040  656 VVIVDEAWDLLKEGEVSVFMEHAYRKFRKYGGSVVIATQSINDLYENA-VGRAIAENSASMYLLGQ 720
Cdd:TIGR03783 668 MILIEEAWKAIASANMAEYIKYLYKTVRKYFGEAIVVTQEVDDIISSPiVKESIINNSDCKILLDQ 733
P-loop_TraG pfam19044
TraG P-loop domain; This entry represents the P-loop domain found in the TraG conjugation ...
450-807 5.56e-20

TraG P-loop domain; This entry represents the P-loop domain found in the TraG conjugation protein.


Pssm-ID: 436917 [Multi-domain]  Cd Length: 413  Bit Score: 93.35  E-value: 5.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  450 TNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAGKSYQKLSEMLNGDFVHFEEGTHVCLNPFeliqnYEDEEDai 529
Cdd:pfam19044  28 TNRNKFILGPSGSGKSFFTNHMVRSYYEQGAHVVLVDVGHSYKGLCELVGGYYFTYSEENPIRFNPF-----YIGDGD-- 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  530 vslvcamasakgLLDEWQISALKQVLSRLWEEKG-------------------KEMKVDDIAERC-------LEEENDQR 583
Cdd:pfam19044 101 ------------VLDTEKKESIKTLLLALWKKDDesftrseyvalsnaltlyyEHLEKDPDIFPCfntfyefLRDEYLKV 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  584 LK---------DIGQQLYA---FTSKGSYGkYF--SRKNNVSFQNQFTVLELDELQGRKHLRQVVLLqliyqIQQEVFLG 649
Cdd:pfam19044 169 LEedkvkekdfDIDNFLYVlrpYYKGGEFD-YLlnATENLDLLNERFIVFELDNIKDHPILFPVVTI-----IIMEVFIS 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  650 eRNRK-----KVVIVDEAWD-LLKEGeVSVFMEHAYRKFRKYGGSVVIATQSINDLYENA-VGRAIAENSASMYLLGQTE 722
Cdd:pfam19044 243 -KMRKlkgirKMILIEEAWKaIAKEG-MAEYIKYLFKTVRKFFGEAIVVTQEVDDIISSPiVKDAIINNSDCKILLDQRK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  723 -----ETVESVkrsgrLTLSEggfhtlKTVHTIQGV---------YSEIFIkSKSG--MGVGRLIVGDFQKLLYSTDPVD 786
Cdd:pfam19044 321 yqnkfDQIQEL-----LGLTD------KEKALILSInkandpgrkYKEVFI-SLGGqlSKVYRTEVSLEEYLAYTTEETE 388
                         410       420
                  ....*....|....*....|.
gi 446560040  787 VNAIDQFVKQGMSIPEAIKAV 807
Cdd:pfam19044 389 KLKVQEYAAKYGGIEKGIAAL 409
DUF5934 pfam19357
Family of unknown function (DUF5934); This presumed domain found in type IV secretion system ...
288-434 1.60e-13

Family of unknown function (DUF5934); This presumed domain found in type IV secretion system proteins is functionally uncharacterized. This domain family is found in proteobacteria, and is approximately 170 amino acids in length. The family is found in association with pfam11130. There are two conserved sequence motifs: GWDL and QGEY.


Pssm-ID: 437189 [Multi-domain]  Cd Length: 172  Bit Score: 69.35  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  288 FPEAESTKNTLERKRQFTVNQAYGPMLKFVPVLADKKESFDTLYESMKEGAKPVKITYSVVLFAPtKERVEAAAMAARNI 367
Cdd:pfam19357  23 YPDQEAASSKAGYKFMRTTSLADSKSARFLPQLKEQSAEWQHVQDELRQGRKLVRAFYSVTAFSP-KGKGDAHERTLKSV 101
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446560040  368 WRESRFELMEDKFVALPMFLNCLPFCT----DRDAVRdLFRYKTMTTEQAAVVLPVFGEWKGTGTYHAALI 434
Cdd:pfam19357 102 YKAAGWDLIDERYLQIMGLLAAMPLTLadglASDLER-MKRFRTMLTTTAANIAPLQGEYLGGPIPHLLLI 171
HerA COG0433
Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase ...
450-705 3.32e-13

Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains [Replication, recombination and repair];


Pssm-ID: 440202 [Multi-domain]  Cd Length: 388  Bit Score: 72.33  E-value: 3.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 450 TNKNLVIAAESGSGKSFLTNELIFSYLSEGAQVWVIDAGKSYQKLSEM--LNGDFVHFE--EGTHVCLNPFELIQNYEDe 525
Cdd:COG0433   46 LNRHILILGATGSGKSNTLQVLLEELSRAGVPVLVFDPHGEYSGLAEPgaERADVGVFDpgAGRPLPINPWDLFATASE- 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 526 edaivslVCAMASAKGLLDEWQISALKQVLSRLWEEKGKEMKVDDIAERCLEEENDQR---------LKDIGQQLYAFTS 596
Cdd:COG0433  125 -------LGPLLLSRLDLNDTQRGVLREALRLADDKGLLLLDLKDLIALLEEGEELGEeygnvsaasAGALLRRLESLES 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 597 KGSY--GKYFSRKNNVSFQNQFTVLELDELQGRkhLRQVVLLQL---IYQIQQEVFLGERNRKKVVIV-DEAWDLLKEGE 670
Cdd:COG0433  198 ADGLfgEPGLDLEDLLRTDGRVTVIDLSGLPEE--LQSTFVLWLlreLFEARPEVGDADDRKLPLVLViDEAHLLAPAAP 275
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446560040 671 vsvfmEHAYRKF-------RKYGGSVVIATQSINDLYENAVG 705
Cdd:COG0433  276 -----SALLEILeriaregRKFGVGLILATQRPSDIDEDVLS 312
AAA_10 pfam12846
AAA-like domain; This family of domains contain a P-loop motif that is characteriztic of the ...
450-699 2.09e-10

AAA-like domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins, including VirB4 components of the Type IV secretory pathway and conjugal transfer protein TrbE. This entry includes the arcaheal Vir4/HerA homolog CedB, a membrane-bound protein that is highly induced upon UV treatment and essential for DNA transfer between Sulfolobus cells.


Pssm-ID: 315512 [Multi-domain]  Cd Length: 362  Bit Score: 63.18  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  450 TNKNLVIAAESGSGKSFlTNELIFSYLS-EGAQVWVIDAGKSYQKLSEML-----NGDFVHFEEGT--HVCLNPFELiqn 521
Cdd:pfam12846  20 NAPHSAIIGDLGGGKSV-LNKTLFYYIVlLGGKALYIDPKKERGQWKETLpeiahEINFVTLDSETenHGLLDPIVL--- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  522 YEDEEDAIvsLVCAMASAKGLLDEWQISALKQVLSRLWEE--KGKEMKVDDIAERcLEEENDQRLKDIGQQLYAFTsKGS 599
Cdd:pfam12846  96 LPREKEAE--STAIDILTNLTGDSSRDDEKFPALRKAVEAvtEGKQRGLLAVIEE-LRKEDPKAARNIADHLESVV-DGS 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  600 YGKY-FSR---KNNVSFQNQFTVLELDELQGRKH-----------LRQVVLLQLIYQIQQEVFLGERNRKKVVIVDEAWD 664
Cdd:pfam12846 172 LAHLlFSDgrvENAISFEKQVTILEVEDLDLPDKaerferltteqLLSVSMMFVIGTFAREFGSSDRKEFKVVFFDEAWI 251
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 446560040  665 LLKEGEVSVFMEHAYRKFRKYGGSVVIATQSINDL 699
Cdd:pfam12846 252 FTSSAQGKTLLKELVRIGRSYNAAVYLVTQSADDV 286
TrwB_TraG_TraD_VirD4 cd01127
TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins; The TraG/TraD/VirD4 family are ...
630-720 1.27e-08

TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins; The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion (T4S) systems, versatile bacterial secretion systems mediating transport of protein and/or DNA. They are present in gram-negative and gram-positive bacteria, as well as archaea. They form hexameric rings and belong to the RecA-like NTPases superfamily, which also includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases.


Pssm-ID: 410871 [Multi-domain]  Cd Length: 144  Bit Score: 54.53  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 630 LRQVVLLQLIYQIQQEVFL--GERNRKKVVIVDEAWDLLKegevSVFMEHAYRKFRKYGGSVVIATQSINDLYENAV--- 704
Cdd:cd01127   53 LRALFFNQLFRALTELASLspGRLPRRVWFILDEFANLGR----IPNLPNLLATGRKRGISVVLILQSLAQLEAVYGkdg 128
                         90
                 ....*....|....*.
gi 446560040 705 GRAIAENSASMYLLGQ 720
Cdd:cd01127  129 AQTILGNCNTKLYLGT 144
VirD4 COG3505
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, ...
454-738 6.27e-07

Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442728 [Multi-domain]  Cd Length: 402  Bit Score: 52.68  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 454 LVIAAeSGSGKSFLTNELIFSYLSEGAQVWVIDA-GKSYQKLSEML--NGDFVH----FEEGTHVCLNPFELIQNYEDEE 526
Cdd:COG3505    3 LVIGP-TGSGKTVGLVIPNLTQLARGESVVVTDPkGDLAELTAGFRrrAGYDVYvfdpFDPERSHRWNPLDEIRDPADAQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 527 DAIVSLVCAMASAKGLLDEWQISA---LKQVLSRLWEEKGKEMkvDDIAERCLEEEND--QRLKDIGQQLYAFTsKGSYG 601
Cdd:COG3505   82 ELAEALIPALGGGGGGDPFWREAAralLAALILALAEEGRRTL--ADVYRLLSEPEEElrELLEALPESPHPPV-ADTLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 602 KYFSRKNNV------SFQNQFTVLELDELQ---GRKH--LRQVV--------------------LLQLIY-QIQQEVF-- 647
Cdd:COG3505  159 AFLNAAEKTrssvlsTLASALELLSDPEVAaltSGSDfdLRDLIrekgtlylvlppddlstlapLLRLLLsQLIRALLrr 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 648 ---LGERNRKKVVIVDEA-----WDllkegevsvFMEHAYRKFRKYGGSVVIATQSINDL---YENAVGRAIAENSASM- 715
Cdd:COG3505  239 aerSGRLPRPVLLLLDEFanlgrLP---------SLETLLATGRGYGIRLVLILQSLAQLeaiYGEEGAETILGNCGTKi 309
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 446560040 716 -----------YL---LGQTEETVESVKRS-GRLTLSE 738
Cdd:COG3505  310 flgvndpetaeYLselLGKRTVERRSESRSrGSRSRSR 347
DUF87 pfam01935
Helicase HerA, central domain; This entry represents the central domain found in archaeal ...
456-649 9.23e-06

Helicase HerA, central domain; This entry represents the central domain found in archaeal proteins such as DNA double-strand break repair helicase HerA (EC:3.6.4.12). HerA is a helicase which is able to utilize either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus. This domain includes the the central RecA-like catalytic core and a flanking four-helix bundle. The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.


Pssm-ID: 376671 [Multi-domain]  Cd Length: 220  Bit Score: 47.75  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  456 IAAESGSGKSFLTNELIFS-YLSEGAQVWVIDAGKSYQKLSEML-NGDFVHFEEGTHVCLNPFELiqNYEDEEDAIVSLV 533
Cdd:pfam01935  28 ILGSTGSGKSNTVAVLLEElLEKKGATVLIFDPHGEYGTLFRDLgAENVNVITPDPELKINPWLL--SPEDLADLLEELN 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  534 CAMASAkglldewQISALKQVLSRLWEEKGKEMKVDDIAERCLEEENDQRL---KDIGQQLYAFTSKGSygKYFSRKNNV 610
Cdd:pfam01935 106 LPNAEV-------QRSILEEALDQLKSEELGKLSIDELIEKILEELLTEAAelnKLSNDAIRRVLDKLE--RLLRSGGLI 176
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 446560040  611 SFQNQFTVLELDELQgrkHLRQVVLLQL--IYQIQQEVFLG 649
Cdd:pfam01935 177 LTSTDIIKLILDILS---KGGKVNIIDLsgVDELLQDLVVS 214
PRK13873 PRK13873
conjugal transfer ATPase TrbE; Provisional
443-718 2.70e-04

conjugal transfer ATPase TrbE; Provisional


Pssm-ID: 237536 [Multi-domain]  Cd Length: 811  Bit Score: 44.52  E-value: 2.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 443 LSLHDSNTNKNLVIAAeSGSGKSFLTNELIFSYLS-EGAQVWVIDAGKSYQKLSEMLNGDFVHF--EEGTHVCLNPFELI 519
Cdd:PRK13873 434 LSLHVGDVGHTLVVGP-TGAGKSVLLALMALQFRRyPGAQVFAFDFGGSIRAATLAMGGDWHDLggGADGSVALQPLARI 512
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 520 qnyeDEEDAivslvCAMASakglldEWqisalkqVLSRLWEEK---GKEMKVD-----------DIAERCLE------EE 579
Cdd:PRK13873 513 ----DDEAE-----RAWAA------EW-------IAGILAREGvavTPEVKEHiwsaltslasaPVEERTLTglsvllQS 570
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040 580 NDqrLKdigQQLYAFTSKGSYGKYFSRKNNVSFQNQFTVLELDELQGRKHLRQVVLLQLIYQIQQEvFLGernRKKVVIV 659
Cdd:PRK13873 571 NA--LK---QALAPYCLGGPHGRLLDADAERLGSADVQAFEMEGLMGTKAAAPAVLSYLFHRIEDR-FDG---RPTLLIL 641
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446560040 660 DEAWDLLKEGevsVFMEHA---YRKFRKYGGSVVIATQSINDLYENAVGRAIAENSASMYLL 718
Cdd:PRK13873 642 DEAWLFLDDP---VFAAQLrewLKTLRKKNVSVIFATQSLADIDGSAIAPAIIESCPTRIFL 700
TraG-D_C pfam12696
TraM recognition site of TraD and TraG; This family includes both TraG and TraD as well as ...
675-743 5.58e-03

TraM recognition site of TraD and TraG; This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerization domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.


Pssm-ID: 432726 [Multi-domain]  Cd Length: 125  Bit Score: 37.63  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446560040  675 MEHAYRKFRKYGGSVVIATQSINDL---YENAVGRAIAENSAS-MYL--------------LGQTEETVESVKRSGRLTL 736
Cdd:pfam12696  18 LEKLISTGRSRGISLMLILQSIAQLeelYGKDGAETILGNCNTkVFLgggdeetakylsklLGKYTVVSTTTSSSSSGSG 97

                  ....*..
gi 446560040  737 SEGGFHT 743
Cdd:pfam12696  98 GSGSSSS 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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