|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-451 |
6.96e-102 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 309.51 E-value: 6.96e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 15 YITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGM 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 95 ANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFG 174
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 175 IvallfgllflaehveksagrfdsLGFILSapgfamliyalsqgpskgwispeimstgiagvvfitlfiivelkvkqPML 254
Cdd:cd17503 161 I-----------------------LALLLA-----------------------------------------------PLL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 255 DLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIG 334
Cdd:cd17503 171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 335 LICTAIIFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASIL 414
Cdd:cd17503 251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 446567588 415 AGFGSNNV-------------QSDFLPYQAALIGSAIFLLIALLFSLRIS 451
Cdd:cd17503 331 TNRTQFHHsrlsellaqqvqkQALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
9-414 |
5.39e-87 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 275.03 E-value: 5.39e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 9 VVVSIVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIA 88
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 89 SALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFY 168
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 169 INLPFGIVALLFGLLFLAEHVEKSAGRFDSLGFILSAPGFAMLIYALSQGPSKGWISP-EIMSTGIAGVVFITLFIIVEL 247
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSnEILILSITGLVAIIAFVVWEL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 248 KVKQPMLDLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGA 327
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 328 RKVISIGLICTAIIFVLLSF-VNHDTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIG 406
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIG 400
|
....*...
gi 446567588 407 VAVLASIL 414
Cdd:TIGR00711 401 TALITTIL 408
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-450 |
1.41e-63 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 210.49 E-value: 1.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17321 4 AVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVa 177
Cdd:cd17321 84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 llfgllflaehveksagrfdslGFILSapgfamliyalsqgpskgwispeimstgiagvvfitlfiivelkvkqpmldlr 257
Cdd:cd17321 163 ----------------------ALLLA----------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 llkePVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLIC 337
Cdd:cd17321 168 ----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 338 TAIIFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILAGF 417
Cdd:cd17321 244 TAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 446567588 418 GSNNVQSDFLP-------------YQAALIGSAIFLLIALLFSLRI 450
Cdd:cd17321 324 LSANLGDSGVAallsaaaaafaagFHLAFLVAAALALLAALLALLL 369
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-418 |
6.70e-55 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 186.62 E-value: 6.70e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQvPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17502 4 ALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVA 177
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 LlfgllflaehveksagrfdslgfilsapgfamliyalsqgpskgwispeimstgiagvVFITLFIIVelkvkqpmldlr 257
Cdd:cd17502 163 L----------------------------------------------------------ALLRTILLS------------ 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 llkepvfrkmSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLG-ARKVISIGLI 336
Cdd:cd17502 173 ----------SIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 337 CTAIIFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILAG 416
Cdd:cd17502 243 LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLVA 322
|
..
gi 446567588 417 FG 418
Cdd:cd17502 323 LA 324
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
20-425 |
5.91e-49 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 174.53 E-value: 5.91e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 20 FMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDIT 99
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 100 SLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVALL 179
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 180 FGLLFLAEHVEKSAgRFDSLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGIAGVVFITLFIIVELKVKQPMLDLRLL 259
Cdd:PRK10504 180 ATLMLMPNYTMQTR-RFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLKLF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 260 KEPVFRkMSLISLFSSAGLLGML-FVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICT 338
Cdd:PRK10504 259 RTRTFS-LGLAGSFAGRIGSGMLpFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 339 AIIFVLLSFVNHDTNPWQIRALLFGIGIflgqsVGAVQFSAFNNIT----PPSMGRA-TTIFNVQNRLGSAIGVAVLASI 413
Cdd:PRK10504 338 ALVSLLFMLVALLGWYYLLPFVLFLQGM-----VNSTRFSSMNTLTlkdlPDNLASSgNSLLSMIMQLSMSIGVTIAGLL 412
|
410
....*....|..
gi 446567588 414 LAGFGSNNVQSD 425
Cdd:PRK10504 413 LGLFGQQHVSVD 424
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-405 |
7.43e-46 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 162.84 E-value: 7.43e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 1 MKAKLNPKVVVSIVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLI 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 81 ALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQ 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 161 MSWRWAFYINLPFGIVALLFGLLFLAEHVEKSAGRFDSLGFilsapgfamliyalsqgpskgwispeimstgiagvvfit 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR--------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 241 lfiivelkvkqpmldlRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPW 320
Cdd:COG2814 202 ----------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 321 SYKKLGARKVISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNR 400
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
....*
gi 446567588 401 LGSAI 405
Cdd:COG2814 343 LGGPL 347
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
18-450 |
4.80e-41 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 150.42 E-value: 4.80e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17504 4 AALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLtPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVa 177
Cdd:cd17504 84 LPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 llfgllflaehveksagrfdslgfilsapgfamliyalsqgpskgwispeimstgiagvvfitLFIIVelkvkqPMLDLR 257
Cdd:cd17504 162 ---------------------------------------------------------------LAALV------PLIDLR 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 LLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQN----VIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISI 333
Cdd:cd17504 173 LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLI 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 334 GLICTAIIFVLLSFVNhdTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASI 413
Cdd:cd17504 253 GLVISAVGLLLLALLH--SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446567588 414 LAGF---GSNNVQSDFLPYQAALIGSAIFLLIALLFSLRI 450
Cdd:cd17504 331 LTTYtvsITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-289 |
3.99e-37 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 138.02 E-value: 3.99e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:COG0477 22 GTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVA 177
Cdd:COG0477 102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 LLFGLLFLAEHVEKSAGRFDSLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGIAGVVFITLFIIVELKVKQPMLDLR 257
Cdd:COG0477 182 LVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAA 261
|
250 260 270
....*....|....*....|....*....|..
gi 446567588 258 LLKEPVFRKMSLISLFSSAGLLGMLFVFPLMY 289
Cdd:COG0477 262 LLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-450 |
1.03e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.60 E-value: 1.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpfgiva 177
Cdd:COG2271 98 FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 llfgllflaehveksagrfdslgfilsapgfamliyalsqgpskgwispeimsTGIAGVVFITLFIIVelkvkqpmldlr 257
Cdd:COG2271 170 -----------------------------------------------------LGLPGLLLALLRFWL------------ 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 llkepvfrkMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARK--VISIGL 335
Cdd:COG2271 185 ---------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 336 ICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGqSVGAVQFSAFNNITPPSM-GRATTIFNVQNRLGSAIGVAVLASIL 414
Cdd:COG2271 256 LLAALALLLLALL---PSPALAIALLFLAGFGLG-GAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLL 331
|
410 420 430
....*....|....*....|....*....|....*.
gi 446567588 415 AGFGsnnvqsdflpYQAALIGSAIFLLIALLFSLRI 450
Cdd:COG2271 332 DATG----------YQAAFLLLAALALLAALLALLL 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-449 |
9.00e-31 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 122.29 E-value: 9.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 20 FMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDIT 99
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 100 SLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDqMSWRWAFYInlpfgivall 179
Cdd:cd17474 89 LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFL---------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 180 fgllflaehveksagrfdslgfilsaPGFAMLIyalsqgpskgwispeimstgiagVVFITLFIIVELKVKQPMLD---- 255
Cdd:cd17474 158 --------------------------LAALIPV-----------------------AFLAILFLLPEPKEKAKSSSatkl 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 256 ---LRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIV-PWSYKKLGARKVI 331
Cdd:cd17474 189 rdlKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVgRLLKKRFGARRIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 332 SIGLICTAIIFVLLSFVNhdtNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGvAVLA 411
Cdd:cd17474 269 VIGLLLYALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG-PLLF 344
|
410 420 430
....*....|....*....|....*....|....*...
gi 446567588 412 SILAGFGSNNVQSdflpyqaaLIGSAIFLLIALLFSLR 449
Cdd:cd17474 345 GLLLEIFGLSAPF--------LVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-406 |
9.30e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.98 E-value: 9.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVAL-QTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAN 96
Cdd:pfam07690 4 AAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 97 DITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIV 176
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 177 allfgllflaehveksagrfdslgfilsapGFAMLIYALSQGPSKGwispeimstgiagvvfitlFIIVELKVKQPMLDL 256
Cdd:pfam07690 164 ------------------------------AAVLLLLPRPPPESKR-------------------PKPAEEARLSLIVAW 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 257 RLLKEPVFRKMSLISLFSSAGLLGMLFVFPLmYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLI 336
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 337 CTAIIFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIG 406
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-444 |
1.42e-28 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 116.14 E-value: 1.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 19 MFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDI 98
Cdd:cd17320 8 VALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 99 TSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVAL 178
Cdd:cd17320 88 EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 179 LFGLLFLAEHVEKSAGRFDSLGFILSApgfamliyalsqgpskgwispeimstgiagvvfitlfiivelkvkqpmldLRL 258
Cdd:cd17320 168 LLVLLFLPETLPEEKRKPLLSSLLRAY--------------------------------------------------KRV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 259 LKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICT 338
Cdd:cd17320 198 LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 339 AIIFVLLSFVNHdtnPWQIRALLFGIGIFLgqsvgavQFSAFNNITPPSMGRATTIFNVQNRLGSAI------GVAVLAS 412
Cdd:cd17320 278 LAAALVLLLAAL---LGGLSLWPLVAPLFL-------IFFGFGLIFPNATSLALEPFPHVAGTASALlgflqfLIGALAG 347
|
410 420 430
....*....|....*....|....*....|..
gi 446567588 413 ILAGFGSNNVQSDFLPYQAALIGSAIFLLIAL 444
Cdd:cd17320 348 ALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-451 |
1.81e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 113.05 E-value: 1.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 17 TAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAN 96
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 97 DITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIV 176
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 177 ALLFGLLFLAEHVEKSAGRFDSLGFILSAPgfamliyalsqgpskgwispeimstgiagvvfitlfiivelkvkqpmldL 256
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLRSGL-------------------------------------------------R 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 257 RLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLI 336
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 337 CTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGvavlaSILAG 416
Cdd:cd17325 274 LSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG-----PLLGG 345
|
410 420 430
....*....|....*....|....*....|....*
gi 446567588 417 FgsnnvQSDFLPYQAALIGSAIFLLIALLFSLRIS 451
Cdd:cd17325 346 F-----LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
9-419 |
2.10e-25 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 108.66 E-value: 2.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 9 VVVSIVYITAmfmaAMDATIVNVALQTISKELQVPPSAM-GTVNVGYLVSLAVFLPIsGWLGDRFGTKRVFLIALFVFTI 87
Cdd:PRK14995 9 VIIVLVYIPV----AIDATVLHVAAPTLSMTLGASGNELlWIIDIYSLVMAGMVLPM-GALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 88 ASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSpEERpkiSRFIVLPIAVA-----PAIGPIIGGFFVDQMS 162
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFT-EEK---QRNMALGVWAAvgsggAAFGPLVGGILLEHFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 163 WRWAFYINLPFGIVALLFGLLFLAEHVEKSAGRFDSLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGIAGVVFITLF 242
Cdd:PRK14995 160 WGSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 243 IIVELKVKQPMLDLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSY 322
Cdd:PRK14995 240 IRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 323 KKLGARKVISIGLICTAIIFVLLSFVNHDTNPWQIRALL----FGIGIFLGQSVGAVQFSAfnniTPPSMGRATTIFNVQ 398
Cdd:PRK14995 320 SRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMallgFSAASALLASTSAIMAAA----PPEKAAAAGAIETMA 395
|
410 420
....*....|....*....|.
gi 446567588 399 NRLGSAIGVAVLASILAGFGS 419
Cdd:PRK14995 396 YELGAGLGIAIFGLLLSRSYS 416
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-454 |
1.48e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 102.27 E-value: 1.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 16 ITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMA 95
Cdd:COG2223 11 TLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 96 NDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGI 175
Cdd:COG2223 91 VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 176 VallfgllflaehveksagrfdslgfilsapgFAMLIYALSQGPSKGWISPEimstgiagvvfitlfiivelkvKQPMLD 255
Cdd:COG2223 171 V-------------------------------VAVLAWLFLRDPPAGAAAAA----------------------KASLRD 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 256 LR-LLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIG 334
Cdd:COG2223 198 QLeALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 335 LICTAIIFVLLSFVNHdtNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASIL 414
Cdd:COG2223 278 FALMALGLLLLALALG--SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446567588 415 AGFGSnnvqsdflpYQAALIGSAIFLLIALLFSLRISDKE 454
Cdd:COG2223 356 DATGS---------YTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-450 |
4.56e-23 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 99.95 E-value: 4.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17319 11 AYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpfgiva 177
Cdd:cd17319 91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII-------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 llfgllflaehveksagrfdslgfilsapgfamliyalsqgpskgwispeimsTGIAGVVFITLFIIVelkvkqpmldlr 257
Cdd:cd17319 163 -----------------------------------------------------EGLLGLLLAVLWWFY------------ 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 llkEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWS---YKKLGARKVISIG 334
Cdd:cd17319 178 ---LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLsdrLLRGARRLVIIIG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 335 LICTAIIFVLLSFVnhdTNPWqIRALLFGIGIFLGQSVGAVQFSAFNNITPPSM-GRATTIFNVQNRLGSAIGVAVLASI 413
Cdd:cd17319 255 LLLAAVGLLLAYLT---TSPV-VAVILLSLAGFGIGAASPVFWSLPADLLPGEAaATAGGLINSGGNLGGFVAPLLIGYL 330
|
410 420 430
....*....|....*....|....*....|....*..
gi 446567588 414 LAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSLRI 450
Cdd:cd17319 331 VDATGS---------YTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
18-448 |
9.56e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.55 E-value: 9.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17324 7 AAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpFGIva 177
Cdd:cd17324 87 FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA---IAV-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 llfgllflaehveksagrfdslgfiLSAPGFAMLIYALSQGPSKGWISPEIMSTGiagvvfitlfiivelkvkqpmldLR 257
Cdd:cd17324 162 -------------------------LALLAALLLWRLLPSLPPKKPGSLGLLSSL-----------------------LL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 LLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGaRKVISIGLIC 337
Cdd:cd17324 194 LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG-RRALLIALLL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 338 TAIIFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVGAvqfSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILAGF 417
Cdd:cd17324 273 LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQ---TRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG 349
|
410 420 430
....*....|....*....|....*....|.
gi 446567588 418 GsnnvqsdflpYQAALIGSAIFLLIALLFSL 448
Cdd:cd17324 350 G----------WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-414 |
1.93e-20 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 93.85 E-value: 1.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQV---PPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGM 94
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVAdlgPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 95 ANDITSLNIFRIIQGAGGGLLtPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFV--DQMSWRWAFYINLP 172
Cdd:cd06179 82 AKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 173 FGIVALLFGLLF------LAEHVEKSAG---RFDSLGFILSAPGFAMLIYALSQGPSK-GWISPEIMSTGIAGVVFITLF 242
Cdd:cd06179 161 FNALALILLFFFyhppprPQLHGSSTRQklkRLDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAPLVIGGVLLIAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 243 IIVELKV-KQPMLDLRLLKEP-VFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPW 320
Cdd:cd06179 241 GLYEWKGtKDGLLPPRLLFRGrNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 321 -SYKKLGARKVISIGLICTAIIFVLLSFVNHDtNPWQIRALL----FGIGIFLGQSVGAVQFSafnniTPPS-MGRATTI 394
Cdd:cd06179 321 lLTKIKHIKWQLVAGFVLFTAFLALLALITPD-NKALAIAFSvlagIGIGGPLVLAIVIVQLS-----VPPEdIGTASGL 394
|
410 420
....*....|....*....|
gi 446567588 395 FNVQNRLGSAIGVAVLASIL 414
Cdd:cd06179 395 LGSARALGGAVGTAIFTSIL 414
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
32-409 |
2.19e-19 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 89.75 E-value: 2.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 32 ALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAG 111
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 112 GGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpfgivallfgllflaehvek 191
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF---------------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 192 sagrFDSLGFILSAPGFamliyalsqgpskgWISPEimstgiagvvfiTLFIIVELKVKQPMLD-LRLLKEPVFRKMSLI 270
Cdd:TIGR00710 165 ----LSLAGILLSALIF--------------FILPE------------TLPYEARIQISTYFETfLLLLKSKMFWGYALI 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 271 SLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLSFVN- 349
Cdd:TIGR00710 215 YGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAi 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 350 HDTNPWqirALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAV 409
Cdd:TIGR00710 295 LGLGSW---AMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRLVLGAIV 351
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
13-413 |
9.81e-19 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 87.32 E-value: 9.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 13 IVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALC 92
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 93 GMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERpkisRFIVLPI--AVAP---AIGPIIGGFFVDQMSWRWAF 167
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPR----KNIVFSLfgATAPlgfALGGVFGGLFAQLAWWPWIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 168 YINLpfgivallfgllflaehveksagrfdslgfILSAPGFAMLIYALSqgpskgwispeimstgiagvvfitlfiivel 247
Cdd:cd17476 157 WFLA------------------------------ILAAIVAVAAIFWTS------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 248 kvkqpmldlrllkePVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGA 327
Cdd:cd17476 176 --------------PSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPP 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 328 RKVISIGLICTAIIFVLLSFVNHDTNPWqirALLFGIGIFLG----QSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGS 403
Cdd:cd17476 242 SYIMAISMVAFLVGPILFATMPVHQTYW---AQAFPAMIVAPfgmdFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGI 318
|
410
....*....|
gi 446567588 404 AIGVAVLASI 413
Cdd:cd17476 319 SIGLGIAGTV 328
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-448 |
4.44e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.56 E-value: 4.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQ--MSWRWAFYINLPFGI 175
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 176 VALLFGLLFLAEHVEKSAGRFDSLGFILSAPGFamliyalsqgpskgwispeimstgiagvvfitlfiivelkvkqpmld 255
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNEEASSKSVLKLL----------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 256 LRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARK-VISIG 334
Cdd:cd06174 197 KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 335 LICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASIL 414
Cdd:cd06174 277 LLLMALGLALLLLA---PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
410 420 430
....*....|....*....|....*....|....
gi 446567588 415 AGFGSnnvqsdflpYQAALIGSAIFLLIALLFSL 448
Cdd:cd06174 354 AATFG---------LTGAFLVLAVLLLLAAILLL 378
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-176 |
1.90e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 78.85 E-value: 1.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 52 VGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEE 131
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446567588 132 RPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIV 176
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
13-174 |
2.31e-17 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 83.39 E-value: 2.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 13 IVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALC 92
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 93 GMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLP 172
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
..
gi 446567588 173 FG 174
Cdd:cd17323 162 IS 163
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-448 |
2.57e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.39 E-value: 2.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 59 AVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRF 138
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 139 IVLPIAVAPAIGPIIGGFFVDqMSWRWAFYINLpfgivallfgllflaehveksagrfdsLGFIlsapgfamliyalsqg 218
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL---------------------------LALP---------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 219 pskgwispeimstgIAGVVFITLFIIVELKVKQPMLDLRLLKEPVFRKMSLISLfssAGLLGMLFVF------PLMYQNV 292
Cdd:cd17473 165 --------------VLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYF---LAFLAMLLFYvipiqlPFLLQER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 293 IGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLSFVNhdtNPWQIRALLFGIGIFLGQSV 372
Cdd:cd17473 228 GGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS---GLWVVLLGAILAGLGFGLLL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446567588 373 GAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSL 448
Cdd:cd17473 305 PTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGG---------LSGAFLILGVLALVLAIVLL 371
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-414 |
1.98e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 80.86 E-value: 1.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 1 MKAKLNPKVV-VSIVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFL 79
Cdd:TIGR00895 7 RKQPLSRYQWrAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 80 IALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVD 159
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 160 QMSWRWAFYInlpfGIVALLFGLLFLAEHVEKSAgrfdslgfilsapgfamlIYALSQGPSKgwiSPEIMSTGIAGVVFI 239
Cdd:TIGR00895 167 VFGWRSLFYV----GGIAPLLLLLLLMRFLPESI------------------DFLVSKRPET---VRRIVNAIAPQMQAE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 240 TLFIIVELKVKQPMldLRLLKEPVFR-KMSLISLFSSAGLLGMLFVF--------PLMYQnvIGVSALESGLTTFPEAIG 310
Cdd:TIGR00895 222 AQSALPEQKSTQGT--KRSVFKALFQgKTARITVLLWLLYFMLLVGVyfltnwlpKLMVE--LGFSLSLAATGGALFNFG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 311 LMISSQIVPWSYKKLGaRKVISIGLICTAIIFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVgavqFSAFNNITPPSMGR 390
Cdd:TIGR00895 298 GVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSG----LYALMALFYPTAIR 372
|
410 420
....*....|....*....|....*..
gi 446567588 391 ATTI---FNVqNRLGSAIGVAVLASIL 414
Cdd:TIGR00895 373 ATGVgwaIGI-GRLGAIIGPILAGYLL 398
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-450 |
4.46e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.58 E-value: 4.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 15 YITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGM 94
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 95 ANDITSLN-----IFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYI 169
Cdd:cd06173 84 LALLGSLSlwlllVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 170 NlpfgivallfgllflaehveksagrfdSLGFILSApGFAMLIYALSQGPSKGWISPEIMSTGIAgvvfitlfiivelkv 249
Cdd:cd06173 164 N---------------------------ALSFLLSA-LLLLFIRRPPPAAPGESSSLLLRDLREG--------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 250 kqpmldLRLLKEPVFRKMSLISLFSSAGLLGMLFV-FPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGAR 328
Cdd:cd06173 201 ------LRYLRRSPLLRLLLLALALFALLGGALTVlLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 329 KVISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGqSVGAVQFSAFNNITPPSM-GRATTIFNVQNRLGSAIGv 407
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGG-LFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLG- 349
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 446567588 408 AVLASILAgfgsnnvqsDFLPYQAALIGSAIFLLIALLFSLRI 450
Cdd:cd06173 350 ALLAGLLA---------DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
196-449 |
2.51e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.02 E-value: 2.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 196 FDSLGFILSAPGFAMLIYALSQGPSKGWIspeiMSTGIAGVVFITLFIIVELKVKQPML----------DLR-LLKEPVF 264
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAALGYR----LTALIFAVLGLLAFLLTFFGTKERPVpeeekvslkeSLKaLLKNRPF 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 265 RKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVL 344
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 345 LSFVNHDtNPWQIRALLFGIGIFLGqSVGAVQFSAFNNITPPS--------MGRATTIFNVQNRLGSAIGVAVLASILA- 415
Cdd:COG2211 311 LFFLGPG-NLWLLLVLAALAGIGLG-AILVLPWAMLADVVDYDewktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLAl 388
|
250 260 270
....*....|....*....|....*....|....*...
gi 446567588 416 -GFGSNNVQSD---FLPYQAALIGSAIFLLIALLFSLR 449
Cdd:COG2211 389 fGYVAGAAQSPsalTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-176 |
4.16e-15 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 76.88 E-value: 4.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 32 ALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAG 111
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446567588 112 GGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIV 176
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAIL 157
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
24-446 |
1.18e-14 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 75.35 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 24 MDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNI 103
Cdd:cd17328 13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 104 FRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQ-MSWRWAFYINLPFGIVALLFGL 182
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 183 LFLAEHVEKSAGRfdSLGFILSAPGFAMLIYALSQGPSKGWIspeimSTGIAGVVFIT----LFIivelkvkqpmldlrl 258
Cdd:cd17328 173 LFVREPPRGAAEG--GVMAKSTATSFLADLKALAKNPSFILS-----TLGFTAVSFVTgalaFWA--------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 259 lkePVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVsalesglttfpeAIGLMISSQivpWSYKKLGARKVIS-IGLIc 337
Cdd:cd17328 231 ---PTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGV------------LLGGILADR---LRRKTPRADPLVCaVGLL- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 338 TAIIFVLLSFVNHDTNPWQIRALLFgIGIFLGQSVGAVQFSAFNNITPPSMgRATTIfNVQNRLGSAIGVAV------LA 411
Cdd:cd17328 292 AAAPFLFLALVLALSNLLLAWVLLF-LGEFLLSLNWAPVFAILLYVVIPTR-RSTAS-AIQILLSHLLGDAGspyligLI 368
|
410 420 430
....*....|....*....|....*....|....*.
gi 446567588 412 SILAGFGSNNVQSDFLPYQAAL-IGSAIFLLIALLF 446
Cdd:cd17328 369 SDLLRQNKDSPLAEAASLQYALlLCSFVLVLGGFFF 404
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-448 |
2.49e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.17 E-value: 2.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17489 4 ANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpfgiva 177
Cdd:cd17489 84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 178 llfgllflaehveksagrfdSLGFILSAPGFAMLIYAlsqgpskgwisPEIMSTGIAGVVFITLFIIVELKVKQPMLDLR 257
Cdd:cd17489 156 --------------------AAVLALLALLLVFLVKD-----------PPPVAAEEAEAGTRAFRRLVEKKVLPPALILF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 258 LLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYqnvigvsalesglttfpeAIGLMISSQIVPWSYKKLGARKVISIGLIC 337
Cdd:cd17489 205 LASIAYGAISTFLPLYAAERGISNAGLFFTVY------------------AIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 338 TAIIFVLLSFvnhDTNPWQ--IRALLFGIGIFLGQSvgAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILA 415
Cdd:cd17489 267 LALGLLLLSF---AGSPWMllLAAVLYGLGFGLLFP--ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
410 420 430
....*....|....*....|....*....|...
gi 446567588 416 GFGsnnvqsdflpYQAALIGSAIFLLIALLFSL 448
Cdd:cd17489 342 LFG----------YRAMFLLAAVVVLLALVLYI 364
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
24-442 |
1.45e-13 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 71.98 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 24 MDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNI 103
Cdd:TIGR00893 8 LDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 104 FRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINlpfGIvallfgll 183
Cdd:TIGR00893 88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE---GV-------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 184 flaehveksagrfdsLGFILsapGFAMLIYALSQGPSKGWISPEIMSTGIAGvvfitlfIIVELKVKQP-----MLDLRL 258
Cdd:TIGR00893 157 ---------------LGIIW---GVLWLKFIPDPPQKAKWLTEEEKYIVVGG-------LLAEQQGKGPstpkkYQIKEL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 259 LKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAI--------GLMISSQIVPWSYKKLGARKV 330
Cdd:TIGR00893 212 LKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIvgfigmilGGRLSDLLLRRGKSLVFARKT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 331 ISIGLICTAIIFVLLSFVNhdtNPWQIRALLFgIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVL 410
Cdd:TIGR00893 292 AIIAGLVLSLLMFATNYVN---IPYAALALVA-LGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVI 367
|
410 420 430
....*....|....*....|....*....|..
gi 446567588 411 ASILAGFGSNNVQSDFLPYQAALIGSAIFLLI 442
Cdd:TIGR00893 368 GAIAATTGSFAGALMVVAALALIGALSYLLLV 399
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
19-169 |
6.17e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 69.92 E-value: 6.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 19 MFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDI 98
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446567588 99 TSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYI 169
Cdd:cd17365 88 LQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-448 |
1.77e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.40 E-value: 1.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 18 AMFMAAMDATIVNVALQTISKE--LQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMA 95
Cdd:cd17316 7 GWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 96 NDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFI----VLPIAVAPAIGPIIGGFFVDQMSWRWAFYINL 171
Cdd:cd17316 87 PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRILFLIGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 172 PFGIVallfgllflaehveksagrfdslgfilsapgfamliyalsqgpskgwispeimstgiagVVFITLFIIVelkvkq 251
Cdd:cd17316 167 LPALL-----------------------------------------------------------ALLLRRRTLL------ 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 252 pmldlrllkepvfrkMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVI 331
Cdd:cd17316 182 ---------------LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 332 SIGLICtAIIFVLLSFVNHDTNPWQIrALLFGIGIFLGQSVGAVQFSAFNNITPPSM-GRATTIFNVQNRLGSAIGVAVL 410
Cdd:cd17316 247 VIGLIL-SGILALPLFYLLSGSPTLL-LLLLFILSFFVGGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLI 324
|
410 420 430
....*....|....*....|....*....|....*...
gi 446567588 411 ASILAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSL 448
Cdd:cd17316 325 ALLLASTGG---------TGVPALILALLAIVALIVAL 353
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-455 |
2.62e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 68.36 E-value: 2.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 9 VVVSIVYITAMFMAAMdaTIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIA 88
Cdd:COG2807 19 LLLAIVLVALNLRPAI--TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 89 SALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFsPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFy 168
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 169 inlpfgivallfgllflaehveksagrfdSLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGiagvvfitlfiivelk 248
Cdd:COG2807 175 -----------------------------AVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR---------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 249 vkqpmldlRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNvIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGAR 328
Cdd:COG2807 210 --------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 329 KVISIGLICTAIIFVLLSFVNHDTNPWqIRALLFGIGIFLGQSVGavqFSAFNNITPPSMGRATTIFNVQ--NRLGSAIG 406
Cdd:COG2807 281 RPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQGGLFPLA---LTLIGLRARTPAEAAALSGMAQsvGYLLAALG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 446567588 407 VAVLASILAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSLRISDKEV 455
Cdd:COG2807 357 PLLVGALHDATGS---------WTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-448 |
9.56e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 66.56 E-value: 9.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 21 MAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITS 100
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 101 LNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAV----APAIGPIIGGFFVDQMSWRWAFYinlpFGIV 176
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFL----LGAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 177 allfgllflaehveksagrfdslgfilsaPGFAMLIYALSQGPSKGW-ISPEIMSTGIAGVVFITLFiivelkvkqpmld 255
Cdd:cd17371 166 -----------------------------PALLVLFIRRFVKEPPQWqAARAARRHFADRPSLRELF------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 256 lrllkEPVFRKMSLISLFSSAGLLG----MLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVI 331
Cdd:cd17371 204 -----SPPLLRTTLLASLLATGALGgyygITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNF 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 332 SIGLICTAIIFVLLSFVnhDTNPWQIRALLFGIGIFLGqsvgaVQFSAFNNITP---PSMGRATTIFNVQN--RLGSAIG 406
Cdd:cd17371 279 ALFALGSAISILLYFFL--PLSPTLILILGFPLGFFAS-----GPFSGMGAYLTelfPTAVRATAQGFCYNvgRIIGALF 351
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 446567588 407 VAVLASILAgfgSNNVQSdflpyqAALIGSAIFLLIALLFSL 448
Cdd:cd17371 352 PFLVGFLAT---SGSLGT------AIAVFAAVYYIAGLVLAL 384
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
66-448 |
1.68e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 65.70 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 66 GWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGglLTPVGMAMLFRTFSPEERPKISRFIVLPIAV 145
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 146 APAIGPIIGGFFVDQMSWRWAFYINLpfgivallfgllflaehveksagrfdslgfILSAPGFAMLIYALSQGPskgwis 225
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITA------------------------------ILSLVSLLILLFFVPDPP------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 226 peimstgiagvvfitlfIIVELKVKQPMLDLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNvIGVSALESGLTTF 305
Cdd:cd17472 175 -----------------KIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQ-LGGGKGQLWKVYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 306 PE---AIGLMISSQIVPWSYKKLgaRKVISIGLICTAIIFVLLSFvnHDTNPWQIralLFGIGIFlgqsvgavqFSAFNN 382
Cdd:cd17472 237 PAiliGFILMVPFVIYAEKKGKM--KQVFVSSILLIAVGFLLLLF--AATSLWLL---IIGLIIF---------FIGFNL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446567588 383 ITP--PSM----------GRATTIFNVQNRLGSAIGvAVLASILAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSL 448
Cdd:cd17472 301 LEAllPSLvskiapkeyrGTAMGIYNTSQFLGSFLG-GALGGLLWGLLG---------YSSVFLTILILALLWLLVSF 368
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
31-168 |
8.57e-11 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 63.50 E-value: 8.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 31 VALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGA 110
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446567588 111 GGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFY 168
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFY 161
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
59-313 |
1.51e-10 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 63.53 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 59 AVFLPISGWLGDRFGtKRVFLIALFVFTIASALCG-MANDITSLNIFRIIQGAGGGlltPVGMAMLFrtfSPEERPKISR 137
Cdd:pfam06609 92 AVSILMMGRLTDRFG-RRPFVIATHIIGLVGAIVGcTANKFNTLLAAMTLLGVAAG---PAGASPLF---IGELMSNKTK 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 138 FIVLPIAVAPAI-----GPIIGGFFVDQMSWRWAFYINLPFG------IVALLFGLLFLAEHVEKSAGR-----FDSLGF 201
Cdd:pfam06609 165 FLGLLIVSAPTIamngaGPYFGQRLAIQGNWRWIFYIYIIMSaiavllIIIWYHPPSFAQLHGKKARKRdelakLDWIGI 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 202 ILSAPGFAMLIYALSQG--PSKGWISPEIMSTGIAGVVFITLFIIVEL--KVKQPMLDLRLLKEPV-FRKMSLISLFSSA 276
Cdd:pfam06609 245 FLVIAGTSLFLLGVSWGgkPNNPWNSAKIIGLISSGAGSLVIFALYEVfgKPEQPIIPPALFKDTRgFVCILIISSIMGA 324
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446567588 277 GLLGMLFVFPLMYQNVIGVS-------ALESGLTTFPEAIGLMI 313
Cdd:pfam06609 325 MHLCLTIIYPQQVINIFGSSlknweetAWMSATASFGTGAGVMI 368
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-451 |
3.96e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 3.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 13 IVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALC 92
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 93 GMANDITSLNIFRIIQGAGGGLLTpVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQ---MSWRWAFYI 169
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGLGLLD-VAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 170 nlpfgivallfgllflaehveksagrfdsLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGiagvvfitlfiivelkv 249
Cdd:COG0738 170 -----------------------------LAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL----------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 250 kqpmldLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARK 329
Cdd:COG0738 204 ------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 330 VISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVGAVqFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAV 409
Cdd:COG0738 278 LLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMFPTI-FSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPL 353
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 446567588 410 LASIlagfgsnnvqSDFLPYQAALIGSAIFLLIALLFSLRIS 451
Cdd:COG0738 354 IGFL----------ADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-169 |
6.71e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.67 E-value: 6.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 30 NVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQG 109
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 110 AGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYI 169
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV 162
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-176 |
7.30e-09 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 57.61 E-value: 7.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 1 MKAKLNPKVVVSIVYITAMfmAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLI 80
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAV--GQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 81 ALFVFTIASALCGMANDITSLNIFRIIQGAGggllTPVGMAMLfRT-----FSPEERPKISRFIVLPIAVAPAIGPIIGG 155
Cdd:PRK11652 79 GMSIFILGTLVALFAHSLTVLIAASAIQGLG----TGVGGVMA-RTlprdlYEGTQLRHANSLLNMGILVSPLLAPLIGG 153
|
170 180
....*....|....*....|.
gi 446567588 156 FFVDQMSWRWAFYINLPFGIV 176
Cdd:PRK11652 154 LLTTLFGWRACYLFLLLLGAG 174
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
50-451 |
7.80e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 57.72 E-value: 7.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 50 VNVGYLVSLAVFlpisGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMamlfrTFSP 129
Cdd:TIGR00898 136 FFVGVLLGSFVF----GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAV-----VLNT 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 130 EERPKISRFIV-LPIAVAPAIGPII-GGFFVDQMSWRWafyinlpfgivallfgllflaehveksagrfdsLGFILSAPG 207
Cdd:TIGR00898 207 EFLPKKQRAIVgTLIQVFFSLGLVLlPLVAYFIPDWRW---------------------------------LQLAVSLPT 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 208 FAMLIYAlsqgpskgWISPE----IMSTG-----------IAG----VVFITLFIIVELK----VKQPMLDLRLLKEPVF 264
Cdd:TIGR00898 254 FLFFLLS--------WFVPEsprwLISQGrieealkilqrIAKingkKLPAEVLSLSLEKdlssSKKQYSFLDLFRTPNL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 265 RKMSLISLF----SSAGLLGMLFVFPLMYQNvIGVSALESGLTTFPEAIglmissqIVPWSYKKLGARKVISIGLICTAI 340
Cdd:TIGR00898 326 RKTTLCLMMlwftTAFSYYGLVLDLGNLGGN-IYLDLFISGLVELPAKL-------ITLLLIDRLGRRYTMAASLLLAGV 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 341 IFVLLSFVNHDTNPWQIrallfgIGIFLGQSVGAVQFSA---FNNITPPSMGRATTifnvqnrLGSAIGVAVLASILAGF 417
Cdd:TIGR00898 398 ALLLLLFVPVDLYFLRT------ALAVLGKFGITSAFQMvylYTAELYPTVVRNLG-------VGVCSTMARVGSIISPF 464
|
410 420 430
....*....|....*....|....*....|....*...
gi 446567588 418 gsnNVQSD----FLPYqaALIGSAIFLLIALLFSLRIS 451
Cdd:TIGR00898 465 ---LVYLGekwlFLPL--VLFGGLALLAGILTLFLPET 497
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-230 |
1.00e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 57.21 E-value: 1.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 32 ALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAG 111
Cdd:PRK11043 28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 112 GGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIVALLFGLLFLAEHVEK 191
Cdd:PRK11043 108 VCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKAR 187
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446567588 192 SAGRfDSLGF--ILSAPGFA--MLIYALSQGPSKGWI--SPEIMS 230
Cdd:PRK11043 188 KQSQ-DALTFkqLLKSKTYLgnVLIFAACSAAFFAWLtgSPFILE 231
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
25-167 |
2.22e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 56.04 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 25 DATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIF 104
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446567588 105 RIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRF----IVLPIAVA----PAIGPIIGGFFVDQMSWRWAF 167
Cdd:cd17359 96 RIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmIVFGQLLAyivnYLIANAGGADWLGAEGWRWML 166
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
56-449 |
2.44e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.73 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 56 VSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLtPVGMAMLfRTFSPEERPKI 135
Cdd:cd17391 47 LVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALI-ASQTPKEKSGW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 136 SRFIVLPIAVAPA-IGPIIGGFFVDQMSWRWAFYINLPFGIVALLFGLLFLAE-HVEKSAGRFDSLGFILSAPGFAMLIY 213
Cdd:cd17391 125 ALGTLSTGVVAGTlIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEdFKPVEKKKMVSTKEVWNSVPNPSLLI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 214 ALsqgpskgwispeimstgiagvvFITLFIIvelkvkqpmldlrllkepvfrkmsLISLFSSAGLLGmLFVFPLMyQNVI 293
Cdd:cd17391 205 SL----------------------FVTTFII------------------------QLANQSIEPILT-LYIRQLM-GDAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 294 GVsALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVG 373
Cdd:cd17391 237 NL-AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFV---QTPWQLGILRFLLGLATGGLLP 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446567588 374 AVQfSAFNNITPPSM-GRATTIFNVQNRLGSAIGVAVLASILAGFGsnnvqsdflpYQAALIGSAIFLLIALLFSLR 449
Cdd:cd17391 313 AIN-SLLAKITPKEVaGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG----------YRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
13-175 |
2.69e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 55.64 E-value: 2.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 13 IVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVN----VGYLVSLAvflpISGWLGDRFGTKRVFLIALFVFTIA 88
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLssffWGYALTQV----LGGYLADRFGGKKVLLLAVALWSLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 89 SALCGMAND--ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWA 166
Cdd:cd17380 78 TLLTPLLAYssLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157
|
....*....
gi 446567588 167 FYInlpFGI 175
Cdd:cd17380 158 FYF---FGL 163
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
14-167 |
3.27e-08 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 55.72 E-value: 3.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 14 VYITA-MFMAAMDAtivnvalqtISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALC 92
Cdd:PRK15402 25 TYIANdMIQPGMLA---------VVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAI 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446567588 93 GMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFspEERPKIsRFIVLPIAVA---PAIGPIIGGFFVDQMSWRWAF 167
Cdd:PRK15402 96 LLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESF--EEADAI-KITALMANVAllaPLLGPLVGAALIHVLPWRGMF 170
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-176 |
5.44e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 5.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 9 VVVSIVYITAMFMAAMDATIVNVALQT-----ISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFG--TKRVFLIA 81
Cdd:COG2271 175 LLLALLRFWLLALAYFLVYFALYGFLTwlptyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 82 LFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQM 161
Cdd:COG2271 255 LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
170
....*....|....*
gi 446567588 162 SWRWAFYINLPFGIV 176
Cdd:COG2271 335 GYQAAFLLLAALALL 349
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
53-176 |
7.68e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 54.16 E-value: 7.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 53 GYLVSLAVflpiSGWLGDRFGTKRVFLIALFVFTIASALCGMANDI--TSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPE 130
Cdd:cd17318 68 GYILTQIP----GGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLAQGVTFPAMHALWAKWAPPL 143
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446567588 131 ERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpFGIV 176
Cdd:cd17318 144 ERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI---FGGL 186
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-170 |
1.50e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 53.39 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 36 ISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLL 115
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446567588 116 TPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQmSWRWAFYIN 170
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAA 159
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
1-169 |
2.58e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.57 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 1 MKAKLNPKVVVSIVYITAMFMAAMDATIVNVALqTISKELQVPPSAMGTVNVGYLVSLAVFLPISG-WLGDRFGTKRVFL 79
Cdd:cd17474 191 LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPF-LLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILV 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 80 IALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKIS------RFIvlpiavAPAIGPII 153
Cdd:cd17474 270 IGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASslynfvRFL------GQAVGPLL 343
|
170
....*....|....*.
gi 446567588 154 GGFFVDQMSWRWAFYI 169
Cdd:cd17474 344 FGLLLEIFGLSAPFLV 359
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-418 |
3.36e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 52.38 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 30 NVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQG 109
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 110 AGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQM-SWRWAFYINLPFGIVallfgllflaeh 188
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAII------------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 189 veksagrfdslgfilsapgFAMLIYALSQGPSKGWISPEIMSTGIAGVVFITLFIIVELKVKQpMLDLRLLKEPVFRKMS 268
Cdd:TIGR00881 163 -------------------VSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQ-IFLQYVLLNKVLWYIS 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 269 LISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFV--LLS 346
Cdd:TIGR00881 223 LGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVslLVY 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446567588 347 FVNHDTNPWQIRALLFGIGiFLGQSVGAVQFSAFNNITPPSM-GRATTIFNVQNRLGSAIGVAVLASILAGFG 418
Cdd:TIGR00881 303 WLNPAANPLMDLICLFALG-FLVYGPQMLIGVIASELAPKKAaGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
40-159 |
1.12e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 40 LQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMA--NDITSLNIFRIIQGAGGGLLTP 117
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446567588 118 VGMAMLFRTFSPEERPKISR-------FIVLPIAVAPAIGPIIGGFFVD 159
Cdd:COG2211 339 LPWAMLADVVDYDEWKTGRRreglyfgIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
45-413 |
1.13e-06 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 50.77 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 45 SAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSL---NIFRIIQGAGGGLLTPVGMA 121
Cdd:cd17322 37 SLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYaagSVFYNAGYTGLNLLLTLILA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 122 ----MLFRTFspeerpkISRFIVLPIAVAPAIGPIIGGFFVDQMSWRW---AFYINLPFGIVALLFGLLFLAEHVEKSAG 194
Cdd:cd17322 117 dfssLKNRGF-------ASAIPSLPYIITTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMQRKARKDGE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 195 -------------------------RFDSLGFILSAPGFAMLI--YALSQGPSKGWISPEIMSTGIAGVVFITLFIIVEL 247
Cdd:cd17322 190 ikelknqeteeqtgglsqnlvklfwKLDIFGVILLTAGLGLILvpLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 248 KV-KQPMLDLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLG 326
Cdd:cd17322 270 KFaKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTR 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 327 ARKV-ISIGLICTAI-IFVLLSFVNHDTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSA 404
Cdd:cd17322 350 RYKVlVIIGVPLYIVgMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGA 429
|
....*....
gi 446567588 405 IGVAVLASI 413
Cdd:cd17322 430 VGAAISGAI 438
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
323-446 |
1.99e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 323 KKLGARKVISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVGaVQFSAFNNITPPSMGRATTIFNVQNRLG 402
Cdd:cd17471 260 KRFGKRRLLLAGFLAGVLFYLGLALA---TSLWQLIALQLLNAIFIGITAG-LGISYFQDLMPGQPGLATTLYSNASRIG 335
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 446567588 403 SaigvaVLASILAGFGsnnvqSDFLPYQAALIGSAIFLLIALLF 446
Cdd:cd17471 336 S-----LLGGLLAGVI-----AQYFGYRAVFLVCAVLALLALVL 369
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
66-196 |
2.35e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 49.82 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 66 GWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAV 145
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 446567588 146 APAIGPIIGGFFVDQMSWRWAFYINLPFGIVALLFGLLFLAEHVEKSAGRF 196
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPF 202
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
54-448 |
2.87e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.11 E-value: 2.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 54 YLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGmAMLFRTFSPEERP 133
Cdd:cd17330 43 YSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ-AYIADITDEEERA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 134 KISRFIVLPIAVAPAIGPIIGGFFVDqmswrwafyinlPFGIvallfgllflaehveksagrfdslgfilSAPGFAMLIY 213
Cdd:cd17330 122 KAFGIISAAFGLGFILGPALGGFLST------------PYGY----------------------------ALPFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 214 ALsqgpskgwispeimstgiAGVVFITLFIivelkvkqpmldlrllkePVFRKMSLISLFSSAGLLGMLFVFPLMYQNVI 293
Cdd:cd17330 162 AL------------------LNLVLVLFFL------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 294 GVSALESGLTTFPEAIGLMISSQ-IVPWSYKKLGARKVISIGLICTAIIFVLLSFVnhdtnpWQIRALLFGIGIF-LGQS 371
Cdd:cd17330 206 GFSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA------SSVPLLVLAAAILaFGTG 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446567588 372 VGAVQFSAF--NNITPPSMGRAttifnvqnrLGSAIGVAVLASILAGFGSNNVQSDFLPYQAALIGSAIFLLIALLFSL 448
Cdd:cd17330 280 IVFPALSALlsKSVPSKEQGKA---------QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
253-449 |
3.01e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 253 MLDLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMyQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVIS 332
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 333 IGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLAS 412
Cdd:COG2814 80 LGLLLFALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 446567588 413 ILAGFGsnnvqsdflpYQAALIGSAIFLLIALLFSLR 449
Cdd:COG2814 157 LADLFG----------WRWVFLVNAVLALLALLLLLR 183
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
16-369 |
4.27e-05 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 45.77 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 16 ITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMA 95
Cdd:TIGR00900 5 FAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 96 NDITSLNIFRI-----IQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYIn 170
Cdd:TIGR00900 85 ALLGGLNIWQVyvlagILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWV- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 171 lpfgivallfgllflaehveksagrfDSLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGIAGVVFItlfiivelkvk 250
Cdd:TIGR00900 164 --------------------------DAVGFAISALLIVSVRIPELAASEIQALSNAVLRDTREGIKFV----------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 251 qpmldlrlLKEPVFRKMSLI-SLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARK 329
Cdd:TIGR00900 207 --------LKNPLLRTLLLLaLLFNLVFAPAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMA 278
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446567588 330 VISIGLICTAIIFVLLSFVNhdTNPWQIRALLFGIGIFLG 369
Cdd:TIGR00900 279 LMTGAIFVIGLAILVVGLTP--PNFPLFLVLWFAIGVGYG 316
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
196-448 |
4.80e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.65 E-value: 4.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 196 FDSLGFILSAPGFAMLIyalsqgpskGWISPEIMSTGIAGVVFITLFIIVELKVKQPMLDLRLLKEPVFRKMSL------ 269
Cdd:cd17335 129 WGSIGFGIAALLVGILI---------DRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLAllrnpr 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 270 -ISLFSSAGLLGM----LFVFPLMYQNVIGVSALESGLT----TFPEAIGLMISSQIVpwsyKKLGARKVISIGLICTAI 340
Cdd:cd17335 200 vLAFLLVAFLMGFghglIYSFLFWHLQDLGGSKTLIGLLwtvgVVSEIPFFFFSSRLI----QRFGHVGLLYLGLLAYVV 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 341 IFVLLSFVnhdTNPWqiraLLFGIGIFLGQSVGAVQFSAF---NNITPPSMG-RATTIFN-VQNRLGSAIGvavlaSILA 415
Cdd:cd17335 276 RWLLYSFL---ENPW----LVLPIELLHGLTFALVWAAAVsyaSAAAPPGLRaTAQGLLQgLYFGLGGGLG-----SLIG 343
|
250 260 270
....*....|....*....|....*....|...
gi 446567588 416 GFGSNNVQSdFLPYQAALIGSAIFLLIALLFSL 448
Cdd:cd17335 344 GYLYEAFGA-RTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-176 |
8.25e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 8.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 11 VSIVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDR-FGTKRVFLIALFVFTIAS 89
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 90 ALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQM-SWRWAFY 168
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFL 364
|
....*...
gi 446567588 169 INLPFGIV 176
Cdd:cd06174 365 VLAVLLLL 372
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
33-157 |
8.36e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.55 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 33 LQTISKELqVPPSAMGTVNVGYLVSL-----AVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRII 107
Cdd:cd17388 22 LPTLLREF-VGDSADAATHYGVLLALyalmqFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRII 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446567588 108 QGAGGGLLTpVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFF 157
Cdd:cd17388 101 AGITGATGA-VAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL 149
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
29-169 |
1.00e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.57 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 29 VNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQ 108
Cdd:PRK11551 34 AGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLT 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446567588 109 GAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYI 169
Cdd:PRK11551 114 GVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV 174
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
320-454 |
1.14e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.37 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 320 WSYKKLGARKVISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLGqSVGAVQFSAFNNITPPS-MGRATTIFNVQ 398
Cdd:COG2270 296 RLDDRIGPKRVILVSLVIWIVVCLAAYFL---TTALAFWILGLLIGLVMG-GIQALSRSLLARLIPPGrEAEFFGLYALS 371
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446567588 399 NRLGSAIGVAVLASILAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSLRISDKE 454
Cdd:COG2270 372 GKAASFLGPLLFGLVTQLTGS---------QRLGILSLIVFFVIGLVLLLRVKVPR 418
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-167 |
1.22e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.15 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 50 VNVGYLVSLAVflpiSGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSP 129
Cdd:cd17475 40 LNLGVAVSMLP----AGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPP 115
|
90 100 110
....*....|....*....|....*....|....*...
gi 446567588 130 EERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAF 167
Cdd:cd17475 116 RERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF 153
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-176 |
1.79e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.69 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 8 KVVVSIVYITAMFMAAMDATIVNVALqTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTI 87
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAP-FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 88 ASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTfSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAF 167
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
....*....
gi 446567588 168 YINLPFGIV 176
Cdd:cd17324 356 WVGAALLLL 364
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
47-171 |
2.09e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.53 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 47 MGTVNVGYLVSLAVflpISGWLG--------DRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIqgaggglltpV 118
Cdd:PRK03893 52 LTTVQAASLISAAF---ISRWFGglllgamgDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLV----------I 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446567588 119 GMAM----------LFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINL 171
Cdd:PRK03893 119 GMGMageygssatyVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGI 181
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-462 |
2.71e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 267 MSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLS 346
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 347 FVnhdTNPWQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILAGFGsnnvqsdf 426
Cdd:pfam07690 81 FA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-------- 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 446567588 427 lpYQAALIGSAIFLLIALLFSLRISDKEVMSNKKEK 462
Cdd:pfam07690 150 --WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
45-169 |
3.25e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 45 SAMGtvnVGYLVSlAVFLpisGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLF 124
Cdd:cd17391 247 SATG---VSSLLS-APRL---GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446567588 125 RTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYI 169
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
290-473 |
3.92e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.53 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 290 QNVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLSFVnhdTNPWQIRALLFGIGIFLG 369
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA---PSYPLLLLALFLLGLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 370 qSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAIGVAVLASILAGFGSnnvqsdfLPYQAALIGSAIFLLIALLFSLR 449
Cdd:COG0738 112 -LLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS-------LSWHLPYLILAVLLLLLALLFLR 183
|
170 180
....*....|....*....|....
gi 446567588 450 ISDKEVMSNKKEKTLSVSKKEKAL 473
Cdd:COG0738 184 SKLPEIEEEEEEAAGSAASLKSLL 207
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
52-157 |
5.67e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 42.26 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 52 VGYLVSLAVFL--PISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTpVGMAMLFRTFSP 129
Cdd:cd17389 69 IGSLFSLLQFLssPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSP 147
|
90 100
....*....|....*....|....*...
gi 446567588 130 EERPKISRFIVLPIAVAPAIGPIIGGFF 157
Cdd:cd17389 148 KKRSKGMALIGVAFSLGFIIGPMIGAYF 175
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
38-369 |
5.78e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.21 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 38 KELQVPPSAMGTVNVGY-LVSLAVFLPIsGWLGDRFGTKRVFLIALFVFTIASALC-GMANDITSLNIFRIIQGAGGGll 115
Cdd:cd17490 24 ESLGASLSMIGIILGAYgISQMLLRIPL-GILSDRIGKRKLFIIIGLLFTVLASLImILFPSPWGLLIARFLSGIAAA-- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 116 TPVGMAMLFRT-FSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYINLPFGIvallfgllflaehveksag 194
Cdd:cd17490 101 TWVSFTVLYASyFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGV------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 195 rfdsLGFILSAPgfamliyalsqgpskgwISPEIMSTGIAGVVFITLFiivelkvkqpmldlRLLKEPVFRKMSLISLFS 274
Cdd:cd17490 162 ----LGFILSLF-----------------IKEERREKKPVLTELKELL--------------SVLKDKKLLFFSLLAILQ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 275 SAGLLGMLFVFPLMYQNVIGVSALESGLTTF----PEAIGLMISSQIvpwSYKKLGARKVISIGLICTAIIFVLLSFVNh 350
Cdd:cd17490 207 QMITFSTTFGFTPLIAKQLGASSFQLGLLSIiyllPNALASLLSGTL---FYKKLGERNTIIIGFLLLGAYCFLIPFAP- 282
|
330
....*....|....*....
gi 446567588 351 dtNPWQIRALLFGIGIFLG 369
Cdd:cd17490 283 --NLTLLYLLQALNGFGTG 299
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-169 |
7.24e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 7.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 5 LNPKVVVSIVYITAMFMAAMDATIVNVALqTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFV 84
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPL-LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 85 FTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWR 164
Cdd:cd06173 284 LGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
....*
gi 446567588 165 WAFYI 169
Cdd:cd06173 364 AVFLL 368
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
20-165 |
7.47e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.79 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 20 FMAAMDATIVNVALQTISKELQV--PPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMAND 97
Cdd:cd17315 7 LLFGYDLGVINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPN 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446567588 98 ITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRW 165
Cdd:cd17315 87 VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWW 154
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-173 |
9.57e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 41.41 E-value: 9.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 54 YLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERP 133
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS 113
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446567588 134 KISRFIVLPIAVAPAIGPIIGGFFVDqmsWRW-AFYINLPF 173
Cdd:cd17317 114 FVGILFGLFWALGYMLLALLAYLIRD---WRWlQLAISLPG 151
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
53-190 |
1.01e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 53 GYLVSLAVFL-----PISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAML-FRT 126
Cdd:COG2807 253 GLLLSLFQLAgipgsLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIgLRA 332
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446567588 127 FSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQM-SWRWAFYINLPFGIVALLFGLLFLAEHVE 190
Cdd:COG2807 333 RTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
43-113 |
1.11e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.11 E-value: 1.11e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446567588 43 PPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMA------NDITSLNIFRIIQGAGGG 113
Cdd:cd17364 37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgstplGVMGWLIFFRFLLGIGIG 113
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
54-448 |
1.24e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.06 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 54 YLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNI-FRIIQGAGGGL--LTPVGMAMlfRTFsPE 130
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLgYGVLGGIGAGIgyITPVSTAV--KWF-PD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 131 ERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYInlpFGIVAllfgllflaehveksagrfdslgFILSAPGFAM 210
Cdd:cd17353 124 KRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLI---LGIIF-----------------------LIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 211 LIYalsqgPSKGWISPEIMSTGIAGVVFITLFIIVElkvkqpmldlrLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQ 290
Cdd:cd17353 178 IRD-----PPKGWVPPGVDPLANNAENSPRDYTPRE-----------MLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 291 NVIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLSFVNHDtnpwqirALLFGIGIFLGQ 370
Cdd:cd17353 242 EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSV-------AVLFVLGVALIG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 371 SVGAVQFSAFNNITPPSMGratTIFNVQN--RLGSAIGVA-VLASILAGFGSNNvqsdfLPYQAALIGSAIFLLIALLFS 447
Cdd:cd17353 315 FCYGGGFALFPALTADFFG---TKNAGTNygLLYTAKGVGgLIGPIIAAYVLYT-----GGYNAAFIIAAALSLVALALA 386
|
.
gi 446567588 448 L 448
Cdd:cd17353 387 L 387
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
20-114 |
1.28e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.10 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 20 FMAAMDATIVNVALQTISKELQVPPsaMGTVNVGYLVSLAVFLP-----ISGWLGDRFGTKRVFLIALFVFTIASALCGM 94
Cdd:cd17360 7 FLFGYDTGVISGALLYIKDDLGEVV--LSTGWQELIVSSTVAGAavgaaIGGWLNDRFGRRPCILLADALFTIGAIVMAA 84
|
90 100
....*....|....*....|
gi 446567588 95 ANDITSLNIFRIIQGAGGGL 114
Cdd:cd17360 85 APNKEVLIVGRVLVGLGVGI 104
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
327-452 |
1.32e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.07 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 327 ARKVISIGLICTAIIFVLLSFVNHDTNP-WQIRALLFGIGIFLGQSVGAVQFSAFNNITPPSMGRATTIFNVQNRLGSAI 405
Cdd:cd17345 67 PKRFLAIGLILSAIINILIGFVPSATSSvGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGL 146
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446567588 406 GVAVLASILAGFGSNNVQSDFlpyqaaLIGSAIFLLIALLFSLRISD 452
Cdd:cd17345 147 VGPLAGLGLAIFGDGWWRGAF------IFPAIIAIIVAVIVLFLGKD 187
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-450 |
1.36e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 9 VVVSIVYITAMFMAAMDATiVNVALQTISKELQVPPSAMGT-VNVGYLVSlAVFLPISGWLGDRFGTKRVFLIALFVFTI 87
Cdd:cd17355 3 VVLAVTFLILILSWGIRYY-FGVFIIPIIAEFGWSRAVISLaFTVGLLAF-GLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 88 ASALCGMANDITSLNI-FRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWA 166
Cdd:cd17355 81 GLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 167 FYInlpfgivallfgllflaehveksagrfdsLGFILSAPGFAMLIYALSQGPSKGWISPEIMSTGIAGVVFitlfiive 246
Cdd:cd17355 161 LLV-----------------------------LALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTL-------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 247 lkvkqpmldLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPLMYQNvIGVSALESGLTTFPEAIGLMISSQIVPWSYKKLG 326
Cdd:cd17355 204 ---------KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYS 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 327 ARKVISIGLICTAIIFVLLSFVNHDTnpwqirALLFGIGIFLGQSVGAV----QFSAFNNITPPSMGRATTIFNVQNRLG 402
Cdd:cd17355 274 PRRLLAASYALRALGLALLLLLPFPP------LALLLFAALFGLGWGATvpltAALAARYFGARSYGTLFGLVFAPHQLG 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 446567588 403 SAIGVAVLASILAGFGSnnvqsdflpYQAALIGSAIFLLIALLFSLRI 450
Cdd:cd17355 348 SALGPWLGGLLYDRTGS---------YTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
54-448 |
1.54e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 54 YLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERP 133
Cdd:cd17478 40 FSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 134 KISRFIVLPiAVAPAIGPIIGGFFVDqmswRWAFYINLPFGIvallfgllflaehveksagrfdsLGFILSAPGFAMLIY 213
Cdd:cd17478 120 AMSIFSVGG-NLGFALGPLIAAALVA----LFGGLGLLILLI-----------------------IPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 214 ALSQGPSKGWISPEIMSTGIAGVVFITLFIIvelkvkqpmldlrllkepvfrkmslISLFSSAGLLGMLFVFPLMYQNVi 293
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLI-------------------------IVFLRSWVLSSLTTFLPFYLVQR- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 294 GVSALESGLTTFPEAIGLMISSQIVPWSYKKLGARKVISIGLICTAIIFVLLSFvnhdTNPWQIRALLFGIGIFLGQSvG 373
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL----TPGIWSYILLVLAGFLLFAS-F 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446567588 374 AVQFSAFNNITPPSMGRATTIFnvqnrLGSAIGVAVLASILAGFgsnnvQSDFLPYQAALIGSAIFLLIALLFSL 448
Cdd:cd17478 301 PVTVVLAQELLPGNVGLASGLM-----MGLSFGLGGIGAPVLGA-----LADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
66-171 |
1.78e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 40.68 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 66 GWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAV 145
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153
|
90 100
....*....|....*....|....*.
gi 446567588 146 APAIGPIIGGFFVDQMSWRWAFYINL 171
Cdd:PRK12307 154 GNIIAAYFMPSFAEAYGWRAAFFVGL 179
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
20-176 |
1.84e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.38 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 20 FMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDIT 99
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446567588 100 SLNIFRIIQGAGGGLLTPvGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFVDQM-SWRWAFYINLPFGIV 176
Cdd:cd17333 86 LFVVLMFLAGLGAGILDT-GANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLL 162
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
52-169 |
1.86e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 52 VGYLVSLAVFLPIsGWLGDRFGTKRVFLIALFVFTIASALCGMA-NDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPE 130
Cdd:cd17477 231 AFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGD 309
|
90 100 110
....*....|....*....|....*....|....*....
gi 446567588 131 ERPKISRFIVLPIAVAPAIGPIIGGFFVDQMSWRWAFYI 169
Cdd:cd17477 310 ELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF 348
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
64-175 |
3.61e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 64 ISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITS---LNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIV 140
Cdd:pfam00083 65 FAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQ 144
|
90 100 110
....*....|....*....|....*....|....*...
gi 446567588 141 LPIAVAPAIGPIIG---GFFVDQMSWRWAFYINLPFGI 175
Cdd:pfam00083 145 LAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPAL 182
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
1-176 |
4.00e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 1 MKAKLNPKVVVSIVYITAMFMAaMDATIVNVALqTISKELQVPPSamgtvNVGYLVSLAVFLPI-----SGWLGDRFGTK 75
Cdd:cd17471 193 VKAPVNRRLLLLFAAFTLLFAA-NSMYIIAMPL-YVTNELGGSES-----WVGLLFGLAAALEIpimllAGLLAKRFGKR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 76 RVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMlFRTFSPEERPKISRFIVLPIAVAPAIGPIIGG 155
Cdd:cd17471 266 RLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISY-FQDLMPGQPGLATTLYSNASRIGSLLGGLLAG 344
|
170 180
....*....|....*....|.
gi 446567588 156 FFVDQMSWRWAFYINLPFGIV 176
Cdd:cd17471 345 VIAQYFGYRAVFLVCAVLALL 365
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
66-176 |
4.46e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.34 E-value: 4.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 66 GWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIF--RIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPI 143
Cdd:TIGR00894 97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVfcRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGF 176
|
90 100 110
....*....|....*....|....*....|....
gi 446567588 144 AVAPAI-GPIIGGFFVDQMSWRWAFYInlpFGIV 176
Cdd:TIGR00894 177 QLGTFIfLPISGWLCESWGGWPMIFYV---FGIV 207
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
16-157 |
5.44e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 5.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 16 ITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMA 95
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446567588 96 NDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFF 157
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV 143
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
38-158 |
5.62e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 5.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 38 KELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTp 117
Cdd:cd17390 24 RSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQS- 102
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446567588 118 VGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGPIIGGFFV 158
Cdd:cd17390 103 LCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLA 143
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
6-133 |
6.27e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 6.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 6 NPKVVVSIVYITAMFMAAMDATIV-NVALQTIskeLQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFV 84
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLlPLYLQNV---LGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 446567588 85 FTIASALCGMANDITSLNIF---RIIQGAGGGLLTPVGMAMLFRTFSPEERP 133
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWLIilpLFIRGLGMGLVFMPLNTLALNSLPPEQIG 305
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-395 |
7.17e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.77 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 9 VVVSIVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIA 88
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 89 SALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVlpiaVAPAIGPIIGGFF---VDQM---- 161
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFY----AAAGLGSIFGGLLaygVFKIlgvg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 162 ---SWRWAFYINlpfgivallfgllflaehveksagrfdslGFILSAPGFAMLIYaLSQGPSKGWI-SPE---------- 227
Cdd:cd17327 161 glaGWRWLFIIE-----------------------------GLITIIIGLVIFFW-LPDNPSKAWFlTEEekelaverlr 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 228 IMSTGiAGVVFITLFiivelKVKQPMLDLRLLkepvfrkMSLISLFSSAGLLGMLFVFPLMYQNVIGVSALESGLTTFPE 307
Cdd:cd17327 211 ANQTG-KGDQKFKWK-----QIKEAFKDPRTW-------LLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 308 AIGLMISSQIVPWSYKKLGARKVISIGLICTAII-FVLLSFVnhdTNPWQIRALLFGIGIFLGQSVgAVQFSAFNNITPP 386
Cdd:cd17327 278 GALGAVSLLIAALLSDRFKKRGLFAIFACVLALVgSIILLAA---PNPPGAYFAAYILGGGSYAGF-PILLSWISSNCAG 353
|
....*....
gi 446567588 387 SMGRATTIF 395
Cdd:cd17327 354 YTKRATVLA 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-151 |
8.16e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 8.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 13 IVYITAMFMAAMDATIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASALC 92
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446567588 93 GMANDITSLNIFR---IIQGAGGGLLTPVGMAMLFRTFSPEERPKISRFIVLPIAVAPAIGP 151
Cdd:pfam07690 283 LLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
248-448 |
8.74e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.38 E-value: 8.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 248 KVKQPMLDLRLLKEPVFRKMSLISLFSSAGLLGMLFVFPL-MYQNV----------IGVSALESGLTTFPEAIGLMISSQ 316
Cdd:cd17313 220 EVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDyMGEEVyhgtsaasshYGAGVRMGAWGLLIFSLAFLIFSL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 317 IVPWSYKKLGARKVISIGLICTAIIFVLLSFVNhdtNPWQIRALLFGIGIFLGqSVGAVQFSAFNNITPP---SMGRATT 393
Cdd:cd17313 300 PIGKLGKKIGRKKVYLIGLVLFAVGMALMALVH---NVTVALVLFALGGIGWA-TININPYPLVSDYHSEsgrGQGTDTG 375
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446567588 394 IFNVQnrlgsaigvAVLASILAGFGSNNVQSDFLpYQAALIGSAIFLLIALLFSL 448
Cdd:cd17313 376 LLNLA---------ISLAQILVSLLAGPIIDVKG-YGTVFPVAAVASFLSLVGAL 420
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
27-91 |
8.89e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 38.33 E-value: 8.89e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446567588 27 TIVNVALQTISKELQVPPSAMGTVNVGYLVSLAVFLPISGWLGDRFGTKRVFLIALFVFTIASAL 91
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILL 80
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
49-173 |
9.43e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.10 E-value: 9.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446567588 49 TVNVGYLVSLAVflpiSGWLGDRFGTKRVFLIALFVFTIASALCGMANDITSLNIFRIIQGAGGGLLTPVGMAMLFRTFS 128
Cdd:cd17379 41 SLNLGFLIGSIV----IGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVG 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446567588 129 PEERPKISRFIVLPIAVAPAIGPIIGGFFVdqmSWRW-AFYINLPF 173
Cdd:cd17379 117 SKYRRTVGIVYQMFFTLGLLILPGIAYFIP---HWRWlQLAVTLPN 159
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