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Conserved domains on  [gi|446568012|ref|WP_000645358|]
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MULTISPECIES: MFS transporter [Bacillus]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 10-390 2.63e-62

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 205.54  E-value: 2.63e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  10 FMLVMASDILQQFAIWIRNMALLYFIMERTNnDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSII 89
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  90 GIVLLLKLDYWQ--AIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFT 167
Cdd:cd06173   80 VLALLALLGSLSlwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 168 SLYSLIILFLLSAIALSFLPKWVEKEQVARDSLK-NDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERL 246
Cdd:cd06173  160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 247 GMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVG 326
Cdd:cd06173  240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446568012 327 TLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:cd06173  320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 10-390 2.63e-62

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 205.54  E-value: 2.63e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  10 FMLVMASDILQQFAIWIRNMALLYFIMERTNnDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSII 89
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  90 GIVLLLKLDYWQ--AIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFT 167
Cdd:cd06173   80 VLALLALLGSLSlwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 168 SLYSLIILFLLSAIALSFLPKWVEKEQVARDSLK-NDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERL 246
Cdd:cd06173  160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 247 GMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVG 326
Cdd:cd06173  240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446568012 327 TLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:cd06173  320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-360 8.83e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 101.20  E-value: 8.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   9 AFMLVMASDILQQFAIwirnMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSI 88
Cdd:COG2814   14 ALALGAFLSGLGIGIV----LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  89 IGIVLLLklDYWQaIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTS 168
Cdd:COG2814   90 LLCALAP--SLWL-LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 169 LYSLIILFLLSAIALSFLpkWVEKEQVARDSLKNDIKEgwkyVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERLGM 248
Cdd:COG2814  167 FLVNAVLALLALLLLLRL--LPESRPAARARLRGSLRE----LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 249 EKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTL 328
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                        330       340       350
                 ....*....|....*....|....*....|..
gi 446568012 329 MIQLVPENMVGRVNGtilpLFMGAMLIGTSLA 360
Cdd:COG2814  321 VAELAPPEARGRASG----LYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
18-357 9.69e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.40  E-value: 9.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   18 ILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKL 97
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   98 DYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFL 177
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  178 LSAIALSFL-PKWVEKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFlvIERLGMEKEAVQYL 256
Cdd:pfam07690 163 LAAVLLLLPrPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY--QEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  257 AAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAI---SFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLV 333
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330       340
                  ....*....|....*....|....
gi 446568012  334 PENMVGRVNGTILPLFMGAMLIGT 357
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 46-381 4.97e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 58.40  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   46 VSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIF 125
Cdd:PRK08633   49 TAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAKYGII 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  126 KRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTS-------LYSLIILFLLSAI------ALSFLPKWVEK 192
Cdd:PRK08633  129 PELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPseilgriAPAGLVLLAVAVLglifayRLPKVPAAAPE 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  193 EQVARDSLK-NDIKEGWKYVLHTKNLRMITITFTI-MGLAVGLTNPLEVFlVIERLGM-EKEAVQYLAAADGIGMLLGGI 269
Cdd:PRK08633  209 VFDKKKYLFpKLLWRNLKLLRSDRVLWLAIIGLSYfWFISQLAQANFPAY-AKEVLGLdNTFQVQYLLAASAIGIGIGSL 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  270 VAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRV---NGTIL 346
Cdd:PRK08633  288 LAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVlaaNNFLQ 367

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 446568012  347 PLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALIL 381
Cdd:PRK08633  368 NVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIG 402
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 246-361 2.80e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  246 LGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVV 325
Cdd:TIGR00895  47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNL 126

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446568012  326 GTLMIQLVPEnmvgRVNGTILPLFMGAMLIGTSLAG 361
Cdd:TIGR00895 127 NALVSEYAPK----RFRGTAVGLMFCGYPIGAAVGG 158
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 10-390 2.63e-62

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 205.54  E-value: 2.63e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  10 FMLVMASDILQQFAIWIRNMALLYFIMERTNnDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSII 89
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  90 GIVLLLKLDYWQ--AIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFT 167
Cdd:cd06173   80 VLALLALLGSLSlwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 168 SLYSLIILFLLSAIALSFLPKWVEKEQVARDSLK-NDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERL 246
Cdd:cd06173  160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 247 GMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVG 326
Cdd:cd06173  240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446568012 327 TLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:cd06173  320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 58-390 2.49e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 103.04  E-value: 2.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  58 FIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANA 137
Cdd:cd17325   45 LLFSPPAGRLSDRFGRKRLLLLG---LLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 138 IAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLKNDIKEGWKYVLHTKNL 217
Cdd:cd17325  122 MGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 218 RMITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLV 297
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 298 EGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAM 377
Cdd:cd17325  282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361

                        330
                 ....*....|...
gi 446568012 378 ALILLAIGPVLRM 390
Cdd:cd17325  362 ALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-360 8.83e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 101.20  E-value: 8.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   9 AFMLVMASDILQQFAIwirnMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSI 88
Cdd:COG2814   14 ALALGAFLSGLGIGIV----LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  89 IGIVLLLklDYWQaIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTS 168
Cdd:COG2814   90 LLCALAP--SLWL-LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 169 LYSLIILFLLSAIALSFLpkWVEKEQVARDSLKNDIKEgwkyVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERLGM 248
Cdd:COG2814  167 FLVNAVLALLALLLLLRL--LPESRPAARARLRGSLRE----LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 249 EKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTL 328
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                        330       340       350
                 ....*....|....*....|....*....|..
gi 446568012 329 MIQLVPENMVGRVNGtilpLFMGAMLIGTSLA 360
Cdd:COG2814  321 VAELAPPEARGRASG----LYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
18-357 9.69e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.40  E-value: 9.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   18 ILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKL 97
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   98 DYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFL 177
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  178 LSAIALSFL-PKWVEKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFlvIERLGMEKEAVQYL 256
Cdd:pfam07690 163 LAAVLLLLPrPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY--QEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  257 AAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAI---SFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLV 333
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330       340
                  ....*....|....*....|....
gi 446568012  334 PENMVGRVNGTILPLFMGAMLIGT 357
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 29-388 3.60e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 79.39  E-value: 3.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  29 MALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKLDYWQAIFFATL 108
Cdd:cd06174   16 SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLG---LLLFALGALLFAFAPSFWLLLLGRF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 109 ISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQL--GLFTSLYSLIILFLLSAIALSFL 186
Cdd:cd06174   93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 187 PKWVEKEQVARDSLKN--DIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAADGIGM 264
Cdd:cd06174  173 VPDPPESARAKNEEASskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 265 LLGGIVAAVFASKV-NPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNG 343
Cdd:cd06174  253 ALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446568012 344 TILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAIGPVL 388
Cdd:cd06174  333 LLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 3-403 7.96e-15

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 75.94  E-value: 7.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012    3 ALFKNRAFMLVMASDILQQFAIWIRNMALLYfIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGD- 81
Cdd:pfam05977   5 APLRQGVFRVIWIASLASNLGTLMQDVAASW-LMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQl 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   82 ----------VLSVLSIIGIVLLLKLDYWQAIFFATLIsaivgqfsqPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIF 151
Cdd:pfam05977  84 llalvstlltLLAGLGLLSPWLLLGLTFLGGIGTALMD---------PAWQASVPELVPRRDLPAAVALNSVGYNIARSV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  152 GPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLAV 231
Cdd:pfam05977 155 GPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  232 GLTNPLEVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMR 311
Cdd:pfam05977 235 SAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  312 FGTGIC----LACVNIVVGTlmiqLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAIGPV 387
Cdd:pfam05977 315 LLGGAAwitaLTTLNVAVQL----SVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAG 390

                         410
                  ....*....|....*.
gi 446568012  388 LRMQIKKEDIANKEAL 403
Cdd:pfam05977 391 LRFRLPEGEAADLIPS 406
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 58-384 1.03e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 74.96  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  58 FIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLllkLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANA 137
Cdd:cd17329   49 IVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF---AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 138 IAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVEKEQVARdslKNDIKEGWKYVLHTKNL 217
Cdd:cd17329  126 FSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAE---KTEILRGYKIVLRDRAF 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 218 RMITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLV 297
Cdd:cd17329  203 LLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAV 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 298 EGLSTSFWitsfMRFGTGICLACVNIVV----GTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTS----- 368
Cdd:cd17329  283 LAFANTLA----VLILAMIVLTLGEMLVfpavQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGpglpw 358

                        330
                 ....*....|....*..
gi 446568012 369 -LVTVFCIAMALILLAI 384
Cdd:cd17329  359 lILAALGLIAAALLLGL 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-390 2.29e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.75  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  42 DPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGqFSQPSS 121
Cdd:COG2271   43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG--LLLWGLATLLFGFATSFWQLLLLRFLLGLGEA-GFFPAA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 122 SRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIAlsflpkwvekeqvardslk 201
Cdd:COG2271  120 LKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 202 ndikegwkyvlhtKNLRMITITFTIMGLAVGLTNPLEVFLViERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVN-- 279
Cdd:COG2271  181 -------------RFWLLALAYFLVYFALYGFLTWLPTYLV-EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrr 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 280 PKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSL 359
Cdd:COG2271  247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL 326

                        330       340       350
                 ....*....|....*....|....*....|.
gi 446568012 360 AGGLKELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:COG2271  327 VGYLLDATGYQAAFLLLAALALLAALLALLL 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-384 1.13e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 71.81  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   1 MKALFKNRAFMLVMASDILQQFAIWIRNMALLYFiMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAG 80
Cdd:COG0738    1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPAL-KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  81 DVLSVLSIIGIVLLLklDYWQAIFFATLISAIVGQF---SQPSSSRIFKRYVkeeqvANAIAFNQTLQSLFLIFGPVVGS 157
Cdd:COG0738   80 LLLMALGLLLFALAP--SYPLLLLALFLLGLGLGLLdvaANPYVAALGPETA-----ASRLNLLHAFFSLGALLGPLLGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 158 -LVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVeKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNP 236
Cdd:COG0738  153 lLILLGLSLSWHLPYLILAVLLLLLALLFLRSKL-PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 237 LEVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGI 316
Cdd:COG0738  232 WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGL 311

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446568012 317 CLACVNIVVGTLMIQLVPENMVGRVnGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAI 384
Cdd:COG0738  312 GLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLIL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
215-390 2.63e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 70.39  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 215 KNLRMITITFTIMGLAVGLTNPLeVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAIS 294
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 295 FLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFC 374
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                        170
                 ....*....|....*.
gi 446568012 375 IAMALILLAIGPVLRM 390
Cdd:COG2814  169 VNAVLALLALLLLLRL 184
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
22-398 3.46e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 70.29  E-value: 3.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  22 FAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLLlkLDYWQ 101
Cdd:COG2223   18 FGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA--VSYWL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 102 AIFFATLISAIVGqFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAI 181
Cdd:COG2223   96 LLLLGLLLGIGGG-GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 182 ALSFlpkWVEKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLA-VGLTNPLEVFLViERLGMEKEAVQYLAAAD 260
Cdd:COG2223  175 LAWL---FLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSfIGFSSWLPPYLV-DQFGLSAATAGLLAALF 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 261 GIGMLLGGIVAAVFASKVNPKKMFVFGMGILAIS-FLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVG 339
Cdd:COG2223  251 ALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGlLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAG 330

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 340 RVNGTILPLFMGAMLIGTSLAGGLKELT-SLVTVFCIAMALILLAIGPVLRMQIKKEDIA 398
Cdd:COG2223  331 AVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 226-388 2.25e-12

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 67.58  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 226 IMGLAVGLTNPLeVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFW 305
Cdd:cd17477    7 LLGLGSGLLLPL-LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 306 ITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTslVTVFCIAMALILLAIG 385
Cdd:cd17477   86 VWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG--ALPFLIAAVLLLLALV 163


                 ...
gi 446568012 386 PVL 388
Cdd:cd17477  164 PLL 166
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-363 3.76e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 67.62  E-value: 3.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  17 DILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMeyAPIF--IFSFIGGALADRWNPKR-----TMVAGDVLSVLSII 89
Cdd:COG2211   19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLV--ARLWdaITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  90 GIVLLLKLDYWQAIFFATLISAIVG----QFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLG- 164
Cdd:COG2211   97 LLFTAPDLSPTGKLIYALVTYLLLGlaytLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGg 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 165 -LFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVI 243
Cdd:COG2211  177 dAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 244 ERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLS--TSFWITSFMRFGTGICLACV 321
Cdd:COG2211  257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAI 336

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446568012 322 NIVVGTLMIQLVPENMV---GRVNGTILPLFMGAMLIGTSLAGGL 363
Cdd:COG2211  337 LVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIKLGQALAGAL 381
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 220-390 2.23e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.82  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 220 ITITFTIMGLAVGLTNPLeVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEG 299
Cdd:cd17325    1 LSLALFLDMLGYGIIIPI-LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 300 LSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMAL 379
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                        170
                 ....*....|.
gi 446568012 380 ILLAIGPVLRM 390
Cdd:cd17325  160 ALLALVLALLL 170
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 29-384 3.95e-10

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 60.67  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  29 MALLYFIMERTNN---DPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKLDYWQAIFF 105
Cdd:cd17330   16 FPVLPFYVREFNKlgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLS---LAGSAVSYVLLGLSRNLWLLFL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 106 ATLISAIVGQFSQPSSSRIFKRYVKEEQvANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSF 185
Cdd:cd17330   93 ARFLDGLTGGNVSVAQAYIADITDEEER-AKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLF 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 186 LPKwvekeqvardslkndikegwkyvlhtkNLRMITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAADGIGML 265
Cdd:cd17330  172 FLP---------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGI 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 266 L-GGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGT 344
Cdd:cd17330  225 LaQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGI 304

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 446568012 345 ILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAI 384
Cdd:cd17330  305 IQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
MFS_1 pfam07690
Major Facilitator Superfamily;
220-402 5.93e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 5.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  220 ITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEG 299
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  300 LSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMAL 379
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180
                  ....*....|....*....|...
gi 446568012  380 ILLAIGPVLRMQIKKEDIANKEA 402
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPA 183
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 63-384 9.83e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.53  E-value: 9.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  63 IGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYWQaIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQ 142
Cdd:cd17489   50 FAGRLLDRFGRKRLLLIG--LLIFALATLLYLLATSVAL-LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 143 TLQSLFLIFGPVVGSLVYTQLGlFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLKndikEGWKYVLHTKNLRMITI 222
Cdd:cd17489  127 LATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAG----TRAFRRLVEKKVLPPAL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 223 TFTIMGLAVGLTNPLEVFLVIERlGMEKEAVQYLAAAdgIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLST 302
Cdd:cd17489  202 ILFLASIAYGAISTFLPLYAAER-GISNAGLFFTVYA--IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 303 SFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILL 382
Cdd:cd17489  279 SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL 358


                 ..
gi 446568012 383 AI 384
Cdd:cd17489  359 AL 360
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 46-381 4.97e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 58.40  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   46 VSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIF 125
Cdd:PRK08633   49 TAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAKYGII 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  126 KRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTS-------LYSLIILFLLSAI------ALSFLPKWVEK 192
Cdd:PRK08633  129 PELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPseilgriAPAGLVLLAVAVLglifayRLPKVPAAAPE 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  193 EQVARDSLK-NDIKEGWKYVLHTKNLRMITITFTI-MGLAVGLTNPLEVFlVIERLGM-EKEAVQYLAAADGIGMLLGGI 269
Cdd:PRK08633  209 VFDKKKYLFpKLLWRNLKLLRSDRVLWLAIIGLSYfWFISQLAQANFPAY-AKEVLGLdNTFQVQYLLAASAIGIGIGSL 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  270 VAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRV---NGTIL 346
Cdd:PRK08633  288 LAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVlaaNNFLQ 367

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 446568012  347 PLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALIL 381
Cdd:PRK08633  368 NVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIG 402
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 33-384 1.30e-08

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 56.40  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  33 YFIMERTNNDPVSVSL-LSVMEYAPIFIFSFIGGaLADRWNPKRTMVagdVLSVLSIIGIVLLLKL--DYWQAIFFATLI 109
Cdd:cd17471   21 LFLTEELGASPLQIGIfMTLSALSGIVVSQWLGR-LSDRGGDRKPLI---LLALLAGALGYLLFAFlrNYWVLLLVGVVL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 110 SAIVG-QFSQP-SSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLP 187
Cdd:cd17471   97 LSLGAaAFPQLfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 188 KWVEKEQVARDSLKNDIKegwkyVLHTKNLRMITITFTIMGLA--VGLTN-PLevfLVIERLGMEKEAVQYL---AAADG 261
Cdd:cd17471  177 PSVKPPAQKATPASSLVK-----APVNRRLLLLFAAFTLLFAAnsMYIIAmPL---YVTNELGGSESWVGLLfglAAALE 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 262 IGMLLGgivAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLAcVNIVVGTLMIQ-LVPENMvgr 340
Cdd:cd17471  249 IPIMLL---AGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG-ITAGLGISYFQdLMPGQP--- 321

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 446568012 341 vnGTILPLFMGAM----LIGTSLAGGLKELTSLVTVFCIAMALILLAI 384
Cdd:cd17471  322 --GLATTLYSNASrigsLLGGLLAGVIAQYFGYRAVFLVCAVLALLAL 367
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 18-384 1.55e-08

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 56.07  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  18 ILQQFAIWIrNMALLYFIMERTNNDPVS----VSLLSVMEyapiFIFSFIGGALADRWNPKRTMVagdvLSVLSIIGIVL 93
Cdd:cd17331   10 VLYATCYWL-QQPVLPYLTKKLGVDSVVfgylQTTFSVLQ----LVGGPLFGRFGDLFGPRAALV----LSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  94 LLKLDYWQAIFFATLISAiVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLY-SL 172
Cdd:cd17331   81 LLAFASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALvAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 173 IILFLLSAIALSFLPK--WVEKEQVARDSLKNDIKEGWKYVLH---TKNLRMITITFTIMGLAVGLTNPLEVFLVIERLG 247
Cdd:cd17331  160 VGSLLSIVLVILLIPSntKSKREKEAKESASPPSVFNLKEILRllrLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 248 MEKEAVQYLAAADGI-GMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVG 326
Cdd:cd17331  240 LTPEENGYLMSYAGVlGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVIT 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446568012 327 TLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAI 384
Cdd:cd17331  320 SLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLT 377
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-201 1.98e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.06  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   1 MKALFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAG 80
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  81 DVLSVLSIIGIVLLLKLDYWqAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVAN-------AIAFNQTLQSLFLIFGP 153
Cdd:COG2211  301 LLLAALGLLLLFFLGPGNLW-LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAG 379

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446568012 154 VVGSLVYTQLGL-------------FTSLYSLI--ILFLLSAIALSFLPKWVEKEQVARDSLK 201
Cdd:COG2211  380 ALAGLLLALFGYvagaaqspsaltgIRLLFFLLpaVLLLLAALLLLFYPLTRERHAEIRAELA 442
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 43-384 2.53e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.25  E-value: 2.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  43 PVSVSLLSVMEYA-PIFIFSFIGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYWqAIFFATLISAIVGQFSQPSS 121
Cdd:cd17324   32 SVAQAGLLVSAYAlGYALGALLLGPLSDRIERRRLLLVL--LLLFILGNLLAALAPSFA-LLLLARALAGLAHGGFWAIA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 122 SRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLpkwVEKEQVARDSLK 201
Cdd:cd17324  109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL---LPSLPPKKPGSL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 202 NDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAAdGIGMLLGGIVAAVFASKVNPK 281
Cdd:cd17324  186 GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLF-GVAGVVGSPLAGRLADRGGRR 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 282 KMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENmVGRVNGTILPLFMGAMLIGTSLAG 361
Cdd:cd17324  265 ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGG 343

                        330       340
                 ....*....|....*....|...
gi 446568012 362 GLKELTSLVTVFCIAMALILLAI 384
Cdd:cd17324  344 LVLDHGGWAGVGWVGAALLLLAL 366
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 246-390 3.22e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.86  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 246 LGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVV 325
Cdd:cd17324   29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIA 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446568012 326 GTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFcIAMALILLAIGPVLRM 390
Cdd:cd17324  109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF-LAIAVLALLAALLLWR 172
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
242-387 5.47e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.11  E-value: 5.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 242 VIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACV 321
Cdd:COG2271   36 LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGF 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446568012 322 NIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFcIAMALILLAIGPV 387
Cdd:COG2271  116 FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF-LILGLPGLLLALL 180
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 65-384 6.79e-08

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 54.10  E-value: 6.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  65 GALADRWNPKRTMVAGDVLSVLSIIGIVLLLklDYWQAIFFATLISAIVGQFsQPSSSRIFkRYVKEEQVANAIAFNQTL 144
Cdd:cd17478   52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAP--NYWLLLLLVALAGIGSAAF-HPEGARLA-SQAAGGRRGLAMSIFSVG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 145 QSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLKNDIKEGWKyvlHTKNLRMITITF 224
Cdd:cd17478  128 GNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKG---VWRALLLLLIIV 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 225 TIMGLAV-GLTNPLEVFLVieRLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTS 303
Cdd:cd17478  205 FLRSWVLsSLTTFLPFYLV--QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 304 FWITSFMrFGTGICLACVNIVVGTLMIQLVPENmVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLA 383
Cdd:cd17478  283 IWSYILL-VLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLG 360


                 .
gi 446568012 384 I 384
Cdd:cd17478  361 A 361
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
213-384 1.22e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.35  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 213 HTKNLRMITITFTIMGLAVGLTNPLEVFLViERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILA 292
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLA-EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 293 ISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTV 372
Cdd:COG2223   82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161

                        170
                 ....*....|..
gi 446568012 373 FCIAMALILLAI 384
Cdd:COG2223  162 FLILGILLLVVA 173
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-192 3.06e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.79  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   9 AFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdVLSVLSI 88
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  89 IGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTS 168
Cdd:COG2271  260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339

                        170       180
                 ....*....|....*....|....
gi 446568012 169 LYSLIILFLLSAIALSFLPKWVEK 192
Cdd:COG2271  340 FLLLAALALLAALLALLLLRETRK 363
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 220-390 1.57e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.42  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 220 ITITFTIMGLAVGLTNPLEVfLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEG 299
Cdd:COG0477   19 LALGTFLEGLDFTIVNVALP-SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 300 LSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMAL 379
Cdd:COG0477   98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL 177

                        170
                 ....*....|.
gi 446568012 380 ILLAIGPVLRM 390
Cdd:COG0477  178 GLLALVLRLRL 188
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 42-390 2.15e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  42 DPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYW--------QAIFFATLIS--- 110
Cdd:cd17474   32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG--LLLFGIGGLLCGLSDSFAlllagralQGIGAAGLGPlal 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 111 AIVGQFSqpsssrifkryvKEEQVANAIAFNQTLQSLFLIFGPVVGSLvytqLGLFTSLYSLIILFLLSAIALSFLPKWV 190
Cdd:cd17474  110 TLIGDLF------------EGGERAKAMGLYEAALGLGIAVGPLLGGL----LAAISWRYPFFLLAALIPVAFLAILFLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 191 EKEQVARDSLKNDIKEGWKYVLHTKNLR-MITITFTIMGLAVGLTNPLEVFLViERLGMEKEAVQYLAAADGIGMLLGGI 269
Cdd:cd17474  174 PEPKEKAKSSSATKLRDLKKALRGRGLLtFLVSAFLYFFLYFAFLTYLPFLLE-LLYGISPIIIGLLFAGWSVLLALGSL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 270 VAA-VFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPE----------NMV 338
Cdd:cd17474  253 FVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEeergtasslyNFV 332

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446568012 339 GRVNGTILPLFMGAMLigtslagglkELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:cd17474  333 RFLGQAVGPLLFGLLL----------EIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 277-390 4.27e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.36  E-value: 4.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 277 KVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIG 356
Cdd:cd17489   57 RFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALG 136

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446568012 357 TSLAGGLKELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:cd17489  137 PALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-183 6.30e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 6.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   1 MKALFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAG 80
Cdd:cd06174  196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  81 DVlsVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGP-VVGSLV 159
Cdd:cd06174  276 GL--LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPlLAGFLL 353

                        170       180
                 ....*....|....*....|....
gi 446568012 160 YTQLGLFTSLYSLIILFLLSAIAL 183
Cdd:cd06174  354 AATFGLTGAFLVLAVLLLLAAILL 377
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 58-188 8.92e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 47.45  E-value: 8.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  58 FIFSFIGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGqfSQPSSSR-IFKRYVKEEQVAN 136
Cdd:COG2270  288 ALGALLFGRLDDRIGPKRVILVS--LVIWIVVCLAAYFLTTALAFWILGLLIGLVMG--GIQALSRsLLARLIPPGREAE 363

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446568012 137 AIAFNQTLQSLFLIFGPVVGSLVYTQLG-LFTSLYSLIILFLLSAIALSFLPK 188
Cdd:COG2270  364 FFGLYALSGKAASFLGPLLFGLVTQLTGsQRLGILSLIVFFVIGLVLLLRVKV 416
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 59-383 1.46e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 46.80  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  59 IFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVL------LLKLDYWQAIF---FATLISAIV-GQFSQPSSSRIFkry 128
Cdd:cd17320   49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALassieqLLIARFLQGLGaaaGSVVARAIVrDLYSGAELAKIF--- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 129 vkeeqvanaiafnqTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLKNDIKEGW 208
Cdd:cd17320  126 --------------SLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 209 K-YVLHTKNLRMITITFTIMGLAVGLTNPLEV--FLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFV 285
Cdd:cd17320  192 RaYKRVLKNRRFLGYALALGLSFAGLFAYLAAapFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLR 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 286 FGMGILAISFLVEGLSTSFWITSFMRFGTGICLAC--VNIVVGTLM-IQLVP-ENMVGRVNGTILPLFMGAMLIGTSLAG 361
Cdd:cd17320  272 LGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFfgFGLIFPNATsLALEPfPHVAGTASALLGFLQFLIGALAGALVG 351

                        330       340
                 ....*....|....*....|...
gi 446568012 362 GLKELTSLV-TVFCIAMALILLA 383
Cdd:cd17320  352 LLPNGTALPmGLLILVLGLLALL 374
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 255-363 2.31e-05

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 46.14  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 255 YLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVP 334
Cdd:cd06180   38 WIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHAT 117

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446568012 335 ENMVGRVNGTI-----LPLFMGAMLIGTSLAGGL 363
Cdd:cd06180  118 AAGRGHLIGLLfagvgLGIALSGLLVPAGLGGGL 151
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 13-388 2.51e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.01  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  13 VMASDILQQFAIWIrNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIV 92
Cdd:cd17477    1 LLLSVALLGLGSGL-LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  93 LLLKLDYWQAIFFATLIsAIVGQFSqpSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQlgLFTSLYSL 172
Cdd:cd17477   80 LTDSPWVWFLLRFVMGI-GLAGLFV--VSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA--GALPFLIA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 173 IILFLLSAIALSFLPKwvekeqVARDSLKNDIKEGWKYVlhtKNLRMITITFTIMGLAVG-LTNPLEVFLVieRLGMEKE 251
Cdd:cd17477  155 AVLLLLALVPLLLTRR------AAPEIEEAESISLRRLL---RIAPLALLGAFVAGFLEGaFYSLLPLYGL--RLGLSVA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 252 AVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFL----VEGLSTSFWITSFMrfgTGICLACVNIVVGT 327
Cdd:cd17477  224 QAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALllplVPGLPLALLVLLFL---WGGAAGPLYTLALA 300

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446568012 328 LMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFcIAMALILLAIGPVL 388
Cdd:cd17477  301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLF-LFLAAVALLFLLFL 360
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 220-388 2.55e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.88  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 220 ITITFTIMGLAVGLTNPLEVFLvIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEG 299
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPAL-LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 300 LSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMAL 379
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159


                 ....*....
gi 446568012 380 ILLAIGPVL 388
Cdd:cd06174  160 ALALLAAIL 168
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 262-356 4.04e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 45.26  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 262 IGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRV 341
Cdd:cd17317   36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFV 115

                         90
                 ....*....|....*..
gi 446568012 342 nGTILPLF--MGAMLIG 356
Cdd:cd17317  116 -GILFGLFwaLGYMLLA 131
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 59-389 5.68e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.95  E-value: 5.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  59 IFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLLLKLDYWQAIFFAtLISAIVGQFSQPSSSRI-FKRYVKEEQVANA 137
Cdd:cd17355   53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGL-LGGGGAGTLAAVAFATVaAWWFERRRGLALG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 138 IAFNQTLQSLFLiFGPVVGSLVyTQLGLFTSLYSLIILFLLSAIALSFL---PKWVEKEQVARDSLKNDIKEGWKYVLHT 214
Cdd:cd17355  132 ILTAGGGLGSLV-FLPLGAALI-EAFGWRTALLVLALLALLVLVPVLLLlrrRPADLALRAYDDASPASPGSTLKEALRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 215 KNLRMITITFTIMGLAV-GLTNPLEVFLVIERLGMEKEAVqyLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAI 293
Cdd:cd17355  210 ASFWLLALAFFLCGFAVvGLIVHLVPYLADRGISPAAAAV--ALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRAL 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 294 SFLVEGLSTSfwiTSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLA----GGLKELT-S 368
Cdd:cd17355  288 GLALLLLLPF---PPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGpwlgGLLYDRTgS 364

                        330       340
                 ....*....|....*....|.
gi 446568012 369 LVTVFCIAMALILLAIGPVLR 389
Cdd:cd17355  365 YTAAWALAVALGLIAALLVLP 385
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 8-186 6.27e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.86  E-value: 6.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   8 RAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLS 87
Cdd:cd17321  168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  88 IIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTqLGLFT 167
Cdd:cd17321  248 LLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT-AGLSA 326

                        170
                 ....*....|....*....
gi 446568012 168 SLYSLIILFLLSAIALSFL 186
Cdd:cd17321  327 NLGDSGVAALLSAAAAAFA 345
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 256-410 6.64e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 6.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 256 LAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAIS-----FLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMI 330
Cdd:cd06173   39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLaavlaLLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 331 QLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFCIAMALILLAIGPVLRMQIKKEDIANKEALTNSLASK 410
Cdd:cd06173  119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR 198
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
30-385 9.28e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.48  E-value: 9.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  30 ALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKLDYWQAIFFATLI 109
Cdd:COG2807   39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA---LLLLAAGLLLRSLAPSVALLLAGTAL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 110 SAIVGQFSQPSSSRIFKRYVkEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKW 189
Cdd:COG2807  116 IGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 190 VEKEQVARDSlkndiKEGWKYVLHTKNLRMITITFTIMGLAV-GLTNPLEVFLVieRLGMEKEAVQYLAAADGIGMLLGG 268
Cdd:COG2807  195 RPAAAAAAPA-----AASLRSLWRSPLAWLLTLFFGLQSLLYyAVVAWLPPILR--DAGLSAATAGLLLSLFQLAGIPGS 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 269 IVAAVFASKVNPKKMFVFGMGIL-AISFLVEGLSTSFWITSFMrFGTGICLACVNIVVGTLMIQLVPENM-VGRVNGTIL 346
Cdd:COG2807  268 LLVPLLADRLGDRRPLLLLLGLLgLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRARTPAeAAALSGMAQ 346

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446568012 347 PLFMGAMLIGTSLAGGLKELT---SLVTVFCIAMALILLAIG 385
Cdd:COG2807  347 SVGYLLAALGPLLVGALHDATgswTAALLLLAALAVLMLVAG 388
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 1-114 9.84e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 44.22  E-value: 9.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012    1 MKALFKNRAFMLVMASDILQQFAIWIRNMALLYFiMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAG 80
Cdd:pfam13347 217 LKEVFRNRAFLILLASFLLAALAMGVLNGLLLYY-FRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILG 295

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446568012   81 DVLSVLSIIGIVLLLKLDYWQAIFFATLISAIVG 114
Cdd:pfam13347 296 ALITIAGFALALLLGPNNTLLFLVLYIIIGFGYG 329
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 59-363 1.19e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  59 IFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLllkldywqAIFFATLISAIVGQ-----FSQPSSSRIFKRYVKEEQ 133
Cdd:cd17321   46 ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL--------APSLAFLIAARALQgigaaAIMPASLALIAATFPGER 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 134 VANAIAFNQTLQSLFLIFGPVVGSLVytqLGLFTSLYSLIILFLLSAIALSFLPKWVekeqvardslkndikegwkyvlh 213
Cdd:cd17321  118 RGRALGLWGAVVGIGAALGPLLGGLL---LELFGWRWIFLINVPIGLVALLLARTFS----------------------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 214 TKNLRMITITFTIMGLAVGLTnplevFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAI 293
Cdd:cd17321  172 GAVLAAFLLGAALGGLLFLLP-----LYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446568012 294 SFL---VEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGL 363
Cdd:cd17321  247 GLLllaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 3-183 1.37e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   3 ALFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDV 82
Cdd:cd17316  172 ALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLI 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  83 LSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQ 162
Cdd:cd17316  252 LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331

                        170       180
                 ....*....|....*....|.
gi 446568012 163 LGLFTSLYSLIILFLLSAIAL 183
Cdd:cd17316  332 GGTGVPALILALLAIVALIVA 352
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 31-185 1.38e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.72  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  31 LLYFIMERTNNDPVSVS-LLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvlSVLSIIGIVLLLKLDYWQAIFFATLI 109
Cdd:cd17330  197 FSLFLKDRFGFSPSQIGlLLALVGIAGILAQLLLIPRLAKRLGERKLLRLG---LLLAIIGLLLLPFASSVPLLVLAAAI 273

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446568012 110 SAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSF 185
Cdd:cd17330  274 LAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-182 1.89e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   1 MKALFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAg 80
Cdd:cd17324  191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA- 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  81 dvLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPS-SSRIFKryVKEEQVANAIAFNQTLQSLFLIFGPVVGSLV 159
Cdd:cd17324  270 --LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAlQTRVLR--LAPEARGLASSLYLAAYNLGGALGAALGGLV 345

                        170       180
                 ....*....|....*....|...
gi 446568012 160 YTQLGLFTSLYSLIILFLLSAIA 182
Cdd:cd17324  346 LDHGGWAGVGWVGAALLLLALLL 368
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 262-341 2.23e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.99  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 262 IGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRV 341
Cdd:cd17328   45 ISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRA 124
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 4-187 2.90e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.54  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   4 LFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFiFSFIGGALADRWNPKRTMVAGDVL 83
Cdd:cd17352  179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIV-GRILLGLLADKPRIGRLYLYIFTL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  84 SVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSrIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQL 163
Cdd:cd17352  258 LILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPV-ILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336

                        170       180
                 ....*....|....*....|....*
gi 446568012 164 GLFT-SLYSLIILFLLSAIALSFLP 187
Cdd:cd17352  337 GDYDaAFYFCGACLLLSGVLLFLLP 361
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 216-390 2.96e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.56  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 216 NLRMITITFTIMGLAVGLTNPLEvFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISF 295
Cdd:cd17504  183 NITALLAGFGMFMVFQLLPQLLQ-LPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGL 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 296 L-VEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAG------------- 361
Cdd:cd17504  262 LlLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGailttytvsitsg 341

                        170       180
                 ....*....|....*....|....*....
gi 446568012 362 GLKELTSLVTVFCIAMALILLAIGPVLRM 390
Cdd:cd17504  342 GVPTEGAYVLAFLIGAALALAALLLSLLI 370
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 255-384 4.48e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.20  E-value: 4.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 255 YLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVP 334
Cdd:cd17316   40 LLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAP 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446568012 335 ENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVT------VFCIAMALILLAI 384
Cdd:cd17316  120 SKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwrilfLIGALPALLALLL 175
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 215-383 4.67e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.15  E-value: 4.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 215 KNLRMITITFTIMGLAVGLTNPLeVFLV--IERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASK--VNPKKMFVFGMGI 290
Cdd:cd17352  181 KDPTFVLLALGVSFAMLGFFVPF-VYLPsyAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLI 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 291 LAISFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILpLFMG-AMLIGTSLAGGLKELTSL 369
Cdd:cd17352  260 LGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVL-LFQGlAALVGPPIAGLLRDYTGD 338

                        170
                 ....*....|....
gi 446568012 370 VTVFCIAMALILLA 383
Cdd:cd17352  339 YDAAFYFCGACLLL 352
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 2-114 5.57e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.82  E-value: 5.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   2 KALFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIfIFSFIGGALADRWNPKRTMVAGD 81
Cdd:cd17332  215 KALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGAL-LALLPWPPLKKRFGKKKAFFIGL 293

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446568012  82 VLSVLSIIGIVLLLKLDYWQAIFFATLISAIVG 114
Cdd:cd17332  294 LLAILGLLLLFFLPPGNLVLILVLAVLAGIGYG 326
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 39-385 5.62e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 5.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  39 TNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQ 118
Cdd:cd17473   30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAG--LLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 119 PSSSRIFKRYVKEEQvANAIAFNQTLQSLFLIFGPVVGSLVyTQLGLFT--SLYSLIILFLLSAIALSFLPKWVEKEQVA 196
Cdd:cd17473  108 LATALIGDYFEGEER-AKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRApfLVYLLALPVLILVLLFLPEPARKSKSAAS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 197 RDSLKNDIKegwkyvlhtKNLRMITITFTIMGLAVGL-TNPLEV-FLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVF 274
Cdd:cd17473  186 PGAATAAAL---------PWKRVLPIYFLAFLAMLLFyVIPIQLpFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 275 ASKVNPKKMFVFGMGILAISFLVEGLSTSFWITS----FMRFGTGICLACVNivvgTLMIQLVPENMVGRVNGtilpLFM 350
Cdd:cd17473  257 KRRLGKRRLLAIGFALMALGFLLLALASGLWVVLlgaiLAGLGFGLLLPTLN----SWAMSLVPPELRGRAMG----IVT 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 446568012 351 GAMLIG-----------TSLAGGLKELTSLVTVFCIAMALILLAIG 385
Cdd:cd17473  329 SAFFLGqflsplvlgplVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 147-384 8.20e-04

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 41.33  E-value: 8.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 147 LFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIA---LSFLPKW-VEK-----EQVARDSLKNDIKEGWKYVLHTKNL 217
Cdd:cd06176  146 TMLILGIIVTAIVFGRLLDPYSPERLIQVFQIVALVallLALLALWgVERrrsraALAAEEAPPETFREALRLLWASPQA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 218 RMITITFTIMGLAVGLTNP-LEVFlVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKV-NPKKMFVFGMGILAISF 295
Cdd:cd06176  226 RRFFIFLFLSTLALFMQDViLEPF-GGEVFGMSVGETTRLTAIWGGGTLLGMLLAGFLLSRRlGKKRTAALGCLLSALGF 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 296 LVEGLSTSFWITSFMR-------FGTGIClacvniVVG--TLMIQLVPENMVGrvngtilpLFMG--------AMLIGTS 358
Cdd:cd06176  305 LLLALAGLLGNPWLFRpgvfllgLGNGLF------TVGalTLMMDLTGEGTAG--------LFMGlwgaaqalARGLGTL 370

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446568012 359 LAGGLKELTSLVT---------VFCIAMALILLAI 384
Cdd:cd06176  371 LGGALRDLLRALFgspalayglVFLLEAVLLLVAL 405
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 48-389 1.07e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.07  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  48 LLSVMEYAPIfIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLLlkLDYWQAIFFATLISAIVGQFsQPSSSRIFKR 127
Cdd:cd17475   36 LLSALNLGVA-VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV--GSYPVLLVLLFLVGAGYGSV-QPGGGRAIMR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 128 YVKEEQVANAIAFNQTLQSLflifGPVVGSLVYTQLGLFTSLYSLIIL--FLLSAIALSFLPKWVEKEQVARDSLKNDIK 205
Cdd:cd17475  112 WFPPRERGLAMGIRQTGVPL----GGALAAALLPPLALHYGWRAAFVVagLVSILAAVLFWLFYREPPAASAATESASTL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 206 -EGWKYVLHTKNLRMITI-TFTIMGLAVGLTNPLEVFLvIERLGM-EKEAVQYLAAADGIGMlLGGIVAAVFASKVNPKK 282
Cdd:cd17475  188 lRSLKEVLRNRDVWLIAIaGALLVAPQFALLTFLLLFL-HDHLGLsVVAAGALLAVAQLGGA-LGRIGLGRVSDRVFGGR 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 283 --------MFVFGMGILAISFLVegLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAML 354
Cdd:cd17475  266 rrpvlvitAAIAAAALLVLSLLS--PGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIA 343

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 446568012 355 IGTSLAGGLKELTSLVTVFCIAMALILLAIGPVLR 389
Cdd:cd17475  344 IGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 4-186 1.07e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.06  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012   4 LFKNRAFMLVMASDILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVL 83
Cdd:cd06173  204 LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  84 SVLSIIGIVLLLkldYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQL 163
Cdd:cd06173  284 LGLALLVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360

                        170       180
                 ....*....|....*....|...
gi 446568012 164 GLFTSLYSLIILFLLSAIALSFL 186
Cdd:cd06173  361 GLSAVFLLAGALLLLAALLLLLL 383
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 58-388 1.11e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  58 FIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLLLklDYWQAIFFATLISAIVGQFSQPSSSrifkrYVKEEQVANA 137
Cdd:cd17316   50 PIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP--TPILLLVLRFLQGIGIGGEYPGAST-----YVAEFAPSKR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 138 IAFNQTLQSLFLIFGPVVGSLVYTQLG-LFTSLYSLIILFLLSAIALSFLpkwvekeqvardslkndikegwkYVLHTKN 216
Cdd:cd17316  123 RGFALGLLQSGWALGALLAALVASLLIpLLSGDWGWRILFLIGALPALLA-----------------------LLLRRRT 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 217 LRMITITFTIMGLAVGLTNPLEVFLVIErLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAIS-- 294
Cdd:cd17316  180 LLLILLWFFISFGYYGLTTFLPTYLQTV-LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILal 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 295 FLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELTSLVTVFC 374
Cdd:cd17316  259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338

                        330
                 ....*....|....
gi 446568012 375 IAMALILLAIGPVL 388
Cdd:cd17316  339 LILALLAIVALIVA 352
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 58-390 2.43e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.86  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  58 FIFSFIGGALADRWNPKRTMVAGDVL-SVLSIIGIVlllkLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVAN 136
Cdd:cd17319   52 ALFQVPGGWLLDRFGARKVLAVSMLLwSLFTALTGF----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 137 AIAfnqtLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVekeqvardslkndIKEGWKYVLhtkn 216
Cdd:cd17319  128 ATG----LFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY-------------LRQVWGLAL---- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 217 lrmitITFTIMGLAVGLTNPLEVFLViERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNP---KKMFVFGMGILAI 293
Cdd:cd17319  187 -----GYFGINYALYGLLTWLPTYLK-QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAV 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 294 SFLVEGLSTSFWITSFMRFGTGICLACVNIVVGTLMIQLVPENMVGRVNGTILPLFMGAMLIGTSLAGGLKELT-SLVTV 372
Cdd:cd17319  261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAA 340

                        330
                 ....*....|....*...
gi 446568012 373 FCIAMALILLAIGPVLRM 390
Cdd:cd17319  341 FLFLAAVALLAALLVLLL 358
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 59-322 2.49e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 39.91  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  59 IFSFIGGALADRWNPKRTMVAGdvLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSrIFKRYVKEEQVANAI 138
Cdd:cd17328   49 VLSPIFGYLGDRYNRKWILAVG--ILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPT-IIADLFPKEKRTRAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 139 AFNQTLQSLFLIFGPVVGSLVYTQLG------LFTSLYSLIILFLLSAIaLSFLPKWVEKEQVARDSLKNDIKEGWKYVL 212
Cdd:cd17328  126 GVFYFAIPLGSGLGYVVGGLVAQATGgwrwafRVTGVLGVLLAILLLLF-VREPPRGAAEGGVMAKSTATSFLADLKALA 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 213 HTKNLRMITITFTIM---GLAVGLTNPLEVFLVIERLGMEKEAVQYL-----AAADGIGMLLGGIVAAVFASKVNPKKMF 284
Cdd:cd17328  205 KNPSFILSTLGFTAVsfvTGALAFWAPTFFLRAFGVGDLSSADVGLIfgaitCIAGVLGVLLGGILADRLRRKTPRADPL 284

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446568012 285 VFGMGILA---ISFLVEGLSTSFWITSFMRFGTGICLACVN 322
Cdd:cd17328  285 VCAVGLLAaapFLFLALVLALSNLLLAWVLLFLGEFLLSLN 325
MFS_1 pfam07690
Major Facilitator Superfamily;
2-153 2.60e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012    2 KALFKNRAFMLVMAsdILQQFAIWIRNMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGD 81
Cdd:pfam07690 195 KALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446568012   82 VLSVLSIIGIVLLLKLDYWQAIFFATLISAIVGQFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLIFGP 153
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 246-361 2.80e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  246 LGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAISFLVEGLSTSFWITSFMRFGTGICLACVNIVV 325
Cdd:TIGR00895  47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNL 126

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446568012  326 GTLMIQLVPEnmvgRVNGTILPLFMGAMLIGTSLAG 361
Cdd:TIGR00895 127 NALVSEYAPK----RFRGTAVGLMFCGYPIGAAVGG 158
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 42-293 3.05e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.41  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  42 DPVSVSLLSVMEYAPIFIFSFIGGALADRWNPKRTMVAGDVLSVLSIIGIVLllkLDYWQAIFFATLISAIVGQFSQPSS 121
Cdd:COG0477   47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 122 SRIFKRYVKEEQVANAIAFNQTLQSLFLIFGPVVGSLVYTQLGLFTSLYSLIILFLLSAIALSFLPKWVEKEQVARDSLK 201
Cdd:COG0477  124 LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 202 NDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFLVIERLGMEKEAVQYLAAADGIGMLLGGIVAAVFASKVNPK 281
Cdd:COG0477  204 AALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLL 283

                        250
                 ....*....|..
gi 446568012 282 KMFVFGMGILAI 293
Cdd:COG0477  284 LLLLLLLLALLL 295
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
 28-363 7.51e-03

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 38.36  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012  28 NMALLYFIMERTNNDPVSVSLLSVMEYAPIFIFSFIGGaLADRWN-----PKRTMVAGDVLSVLSIIGIVLLLKLDYWQA 102
Cdd:cd17484   17 WLAVSYYYKDDLHLGPASVQALTSIASLPWAIKPLYGL-LSDSVPifgyrRKPYLILAGALGALSWLALALVSNSSLALA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 103 IFFATLISaivgqFSQPSSSRIFKRYVKEEQVANAIAFNQTLQSLFLI---FGPVVGSLVYtqlGLFTSLYS-------L 172
Cdd:cd17484   96 LLLLLLAS-----LGVAFSDVVIDALVVEASRGAPQSLAGDLQSLCWGssaIGGIVGSYFS---GYLLELLGprtvfavT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 173 IILFLLSAIALSFlpkwVEKEQVARDSLKNDIKEGWKYVLHTKNLRMITITFTIMGLAVGLTNPLEVFL--VIERLGMEK 250
Cdd:cd17484  168 SFFPLLLLIVAFF----VKEERVPPHRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSSGSAMFyfMTNELGFSP 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446568012 251 EAVQYLAAADGIGMLLGGIVAAVFASKVNPKKMFVFGMGILAIS-----FLVEGLSTSFWI--TSFMRFGTGICLACVNI 323
Cdd:cd17484  244 EFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLLgltdlILVTRWNLKLGIpdHAFVLGDDAVVTVIGEI 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 446568012 324 ---VVGTLMIQLVPEnmvgRVNGTILPLFMGAMLIGTSLAGGL 363
Cdd:cd17484  324 lfmPILVLAARLCPP----GIEGTVFALLMSISNLGSLTSSFL 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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