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Conserved domains on  [gi|446576477|ref|WP_000653823|]
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MULTISPECIES: iron ABC transporter permease [Bacillus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-338 4.59e-97

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 289.66  E-value: 4.59e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  30 SLNTGTLSIAPLRVIETLLGY-GNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGL 108
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 109 IVFVTLFHSineSASILIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYTFAS 188
Cdd:COG0609   81 VLAIVLGGG---LSALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 189 RWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGF 268
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 269 IGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-338 4.59e-97

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 289.66  E-value: 4.59e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  30 SLNTGTLSIAPLRVIETLLGY-GNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGL 108
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 109 IVFVTLFHSineSASILIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYTFAS 188
Cdd:COG0609   81 VLAIVLGGG---LSALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 189 RWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGF 268
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 269 IGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 24-336 1.37e-80

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 247.83  E-value: 1.37e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477   24 IAVILISLNTGTLSIAPLRVIETLLGYGNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSG 103
Cdd:pfam01032   3 LLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  104 ASFGLIVFVTLFHSINESAsilIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDET 183
Cdd:pfam01032  83 AALGAVLAILLGGSLSLFA---LPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  184 YTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMA 263
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446576477  264 GGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTK 336
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
54-337 8.04e-69

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 227.03  E-value: 8.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  54 ESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSineSASILIPLFTFGG 133
Cdd:PRK10577 388 QLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPG---AGFGWLLAAALLG 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 134 GVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSAIsLFFSLKLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFIL 213
Cdd:PRK10577 465 ALAALALILLLA--RRGGFAPERLLLTGIALSALFTAL-IQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLL 541

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 214 TPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAG 293
Cdd:PRK10577 542 LALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAA 621

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446576477 294 IIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKT 337
Cdd:PRK10577 622 LLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRS 665
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 67-334 9.26e-51

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 169.27  E-value: 9.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  67 IIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSineSASILIPLFTFGGGVLAAFLIILLAs 146
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIG---LSNYALGAFAFAGALAIALLVLLLA- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 147 dRSKGLLPIRLILVGIAVSAGFSAISLFFSLkLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNA 226
Cdd:cd06550   77 -SRGGLSPSKLILIGIVLSAFFSAGVILISL-LSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 227 LSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTI 306
Cdd:cd06550  155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                        250       260
                 ....*....|....*....|....*...
gi 446576477 307 GRSIFePNSIPAGVVVAALGAPYFLYLL 334
Cdd:cd06550  235 SRTLL-PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-338 4.59e-97

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 289.66  E-value: 4.59e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  30 SLNTGTLSIAPLRVIETLLGY-GNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGL 108
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 109 IVFVTLFHSineSASILIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYTFAS 188
Cdd:COG0609   81 VLAIVLGGG---LSALGLPLAAFLGALLAALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 189 RWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGF 268
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 269 IGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 24-336 1.37e-80

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 247.83  E-value: 1.37e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477   24 IAVILISLNTGTLSIAPLRVIETLLGYGNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSG 103
Cdd:pfam01032   3 LLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  104 ASFGLIVFVTLFHSINESAsilIPLFTFGGGVLAAFLIILLASdRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDET 183
Cdd:pfam01032  83 AALGAVLAILLGGSLSLFA---LPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  184 YTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMA 263
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446576477  264 GGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTK 336
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 11-337 4.10e-79

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 245.03  E-value: 4.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  11 RAITVTTIFGCISIAVILISLNTGTLSIAPLRVIETLLGYGNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRN 90
Cdd:COG4779   21 RALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  91 TLADPGILGLHSGASFGLIVFVTLFHSinesASILIPLFTFGGGVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSA 170
Cdd:COG4779  101 PLASPDIIGITAGASAGAVAAIVVLGG----SGLAVALGALAGGLATALLVYLLA--WRGGVSGYRLILVGIGVSAMLTA 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 171 ISLFFSLKLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLA 250
Cdd:COG4779  175 VNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 251 TAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPlAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYF 330
Cdd:COG4779  255 VAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYL 333


                 ....*..
gi 446576477 331 LYLLTKT 337
Cdd:COG4779  334 LWLLIRE 340
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
54-337 8.04e-69

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 227.03  E-value: 8.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  54 ESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSineSASILIPLFTFGG 133
Cdd:PRK10577 388 QLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPG---AGFGWLLAAALLG 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 134 GVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFSAIsLFFSLKLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFIL 213
Cdd:PRK10577 465 ALAALALILLLA--RRGGFAPERLLLTGIALSALFTAL-IQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLL 541

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 214 TPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAG 293
Cdd:PRK10577 542 LALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAA 621

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446576477 294 IIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYLLTKT 337
Cdd:PRK10577 622 LLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRS 665
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
11-338 4.31e-66

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 210.67  E-value: 4.31e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  11 RAITVTTIFGCISIAVILISLNTGTLSIaPLRVIETLLGYGNfESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRN 90
Cdd:PRK09777   1 MKIALVIFITLALAGCALLSLRMGVIPL-PWRALLTDWQAGD-EHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  91 TLADPGILGLHSGASFGLIVFVTLFHSInesASILIPLFTFGGGVLAAFLIILLASDRSkgllPIRLILVGIAVSAGFSA 170
Cdd:PRK09777  79 PLASPDILGVNHAASLASVGALLLFPSL---PVMWLPLLAFIGGMAGLILLKMLAGTHQ----PMKLALTGVALSALWAS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 171 ISLFFSLKLNDETYTfASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLA 250
Cdd:PRK09777 152 LTDYLMLSRPQDINN-ALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 251 TAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYF 330
Cdd:PRK09777 231 LAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWF 310


                 ....*...
gi 446576477 331 LYLLTKTK 338
Cdd:PRK09777 311 FWLLVRMR 318
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
58-338 2.11e-54

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 188.51  E-value: 2.11e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  58 VLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSINESASiliPLFTFGGGVLA 137
Cdd:PRK10577  57 LLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALLALAS---QLAAFAGGLLA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 138 AFLIILLASdrSKGLLPIRLILVGIAVSAGFSAISLFFSLkLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFILTPYA 217
Cdd:PRK10577 134 AALVFALAG--GKRLSPLRLVLAGMVVSLYLGALTTLLLL-FNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLL 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 218 WLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGM 297
Cdd:PRK10577 211 LLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGA 290

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446576477 298 IILVLADTIGRSI--FEPNSIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:PRK10577 291 LLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLPRLR 333
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 67-334 9.26e-51

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 169.27  E-value: 9.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  67 IIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSineSASILIPLFTFGGGVLAAFLIILLAs 146
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIG---LSNYALGAFAFAGALAIALLVLLLA- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 147 dRSKGLLPIRLILVGIAVSAGFSAISLFFSLkLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNA 226
Cdd:cd06550   77 -SRGGLSPSKLILIGIVLSAFFSAGVILISL-LSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 227 LSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTI 306
Cdd:cd06550  155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                        250       260
                 ....*....|....*....|....*...
gi 446576477 307 GRSIFePNSIPAGVVVAALGAPYFLYLL 334
Cdd:cd06550  235 SRTLL-PSELPVGPVTALLGAPYFLYLL 261
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
10-334 1.12e-50

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 171.43  E-value: 1.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  10 KRAITVTTIFGCISIAVILISLNTGTLSIAPLRVIETLLGYGNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSR 89
Cdd:PRK10440   6 RRLLITCLLLLAACVAAGLWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  90 NTLADPGILGLHSGASFGLIVFVTLFhsinESASILIPLFTFGGGVLAAFLIILLAsdRSKGLLPIRLILVGIAVSAGFS 169
Cdd:PRK10440  86 NPLGSPDVMGFNTGAWSGVLVAMVLF----GQDLTAIALAAMAGGIVTSLLVWLLA--WRNGIDTFRLIIIGIGVRAMLV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 170 AISLFFSLKLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLL 249
Cdd:PRK10440 160 AFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLM 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 250 ATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTyQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPY 329
Cdd:PRK10440 240 LVAVVLTAAATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIY 318


                 ....*
gi 446576477 330 FLYLL 334
Cdd:PRK10440 319 LIVLL 323
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 1-338 6.38e-47

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 161.66  E-value: 6.38e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477   1 MKDLFNTDKKRAITVTTIFGCISIAVILISLNTGTLSIAPLRVIETLlgygnfeSATVLYDYRMPRIIITMLAGIGLGIS 80
Cdd:PRK03784   3 MLTLARQQQRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLSPR-------GELFVWQLRLPRTLAVLLVGAALAVS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  81 GAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSINesASILIPLFTFGGGVLAAFLIILLAsdRSKGLLPIRLILV 160
Cdd:PRK03784  76 GAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLL--PPWALSLCAIAGALLITLILLRFA--RRHRLSTSRLLLA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 161 GIAVSAGFSAI---SLFFSLKLNDETYTFasrWLVGNVWGRDWIH---VFALLPWIFILTpyawLKSKTLNALSLGDSVA 234
Cdd:PRK03784 152 GVALGIICSALmtwAVYFSTSLDLRQLMY---WMMGGFGGVDWRQswlMLALLPVLIWLC----CQGRPLNMLALGEISA 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 235 AGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPN 314
Cdd:PRK03784 225 RQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASA 304

                        330       340
                 ....*....|....*....|....
gi 446576477 315 SIPAGVVVAALGAPYFLYLLTKTK 338
Cdd:PRK03784 305 ELPIGVVTATLGAPVFIWLLLRSH 328
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 4-338 7.51e-47

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 161.17  E-value: 7.51e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477   4 LFNTDKKRAITVTTIFGCISIAVILISLNTGTLSIAPLRVIETLLGYgnfesatVLYDYRMPRIIITMLAGIGLGISGAI 83
Cdd:COG4139    3 LPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLSEAWQL-------FVWQLRLPRTLAAVLVGASLAVSGAV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  84 LQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSINESASILIPLFTfggGVLAAFLIILLASDRSKGllPIRLILVGIA 163
Cdd:COG4139   76 MQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLAAIA---GALLVTLLLLAFARRRLS--NARLLLIGVA 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 164 VSAGFSAI---SLFFSLKLNDETYTFasrWLVGNVWGRDWIHvfaLLPWIFILTPYAWL--KSKTLNALSLGDSVAAGLG 238
Cdd:COG4139  151 LGIICSAImtwAVYFSSSLDLRQLMY---WMMGSFGGVDWRQ---LWLLLALLPVLLWLclQGKPLNLLLLGENQARQLG 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 239 VSVQKER-LLLLATAVgLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIP 317
Cdd:COG4139  225 LSVHRWRnLLVLATGL-LVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELP 303

                        330       340
                 ....*....|....*....|.
gi 446576477 318 AGVVVAALGAPYFLYLLTKTK 338
Cdd:COG4139  304 IGVVTATLGAPVFIWLLLRRR 324
btuC PRK09535
cobalamin ABC transporter permease BtuC;
57-336 5.04e-46

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 160.30  E-value: 5.04e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  57 TVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTLFHSInesaSILIPLFTFGGGVL 136
Cdd:PRK09535  89 TIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAV----PFGLQAAAFAGALV 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 137 AAFLIILLASDrsKGLLPI-RLILVGIAVSAGFSAISLFFSLKLNDETYTfASRWLVGNVWGRDWIHVFALLPWIFILTP 215
Cdd:PRK09535 165 AAFGVYAIATE--NGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGESLRR-AVYWLMGHLHGSTWSDVEVALPVVVVGFV 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 216 YAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGII 295
Cdd:PRK09535 242 VLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALA 321

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446576477 296 GMIILVLADTIGRSifEPNSIPAGVVVAALGAPYFLYLLTK 336
Cdd:PRK09535 322 GASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
36-333 2.28e-44

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 154.47  E-value: 2.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  36 LSIAPLRVIETLL-GYGNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRNTLADPGILGLHSGASFGLIVFVTL 114
Cdd:PRK11228  23 IPISAADALNALLpGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSAL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 115 FHSINESASIliPLFTFGGGVLAAFLIILLASDRSKGLLPIRLILVGIAVSAGFSAISLFFSLKLNDETYTFASrWLVGN 194
Cdd:PRK11228 103 SPTPFAGYSL--AFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFY-WLAGG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 195 VWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLLLATAVGLSCTSVSMAGGIGFIGLVAP 274
Cdd:PRK11228 180 VSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVP 259

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446576477 275 HIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFEPNSIPAGVVVAALGAPYFLYL 333
Cdd:PRK11228 260 HLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
11-333 7.84e-43

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 151.01  E-value: 7.84e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  11 RAITVTTIFGCISIAVILiSLNTGTLSIAPLRVIETLLGYGNFESATVLYDYRMPRIIITMLAGIGLGISGAILQGLSRN 90
Cdd:PRK10441   9 RAIAVPGLLLLLIIATAL-SLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477  91 TLADPGILGLHSGASFGLIVFVTLF--HSINEsasilIPLFTFGGGVLAAFLIILLASDRSKGLLPIRLILVGIAVSAGF 168
Cdd:PRK10441  88 PLADPGLLGVNAGASFAIVLGAALFgySSAQE-----QLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 169 SAISLFFSLkLNDETYTFASRWLVGNVWGRDWIHVFALLPWIFILTPYAWLKSKTLNALSLGDSVAAGLGVSVQKERLLL 248
Cdd:PRK10441 163 EGLTSGIAL-LNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576477 249 LATAVGLSCTSVSMAGGIGFIGLVAPHIARKLVGTTYQHFLPLAGIIGMIILVLADTIGRSIFePNSIPAGVVVAALGAP 328
Cdd:PRK10441 242 LLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAP 320


                 ....*
gi 446576477 329 YFLYL 333
Cdd:PRK10441 321 VLIFL 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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