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Conserved domains on  [gi|446576541|ref|WP_000653887|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Bacillus]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 11449697)

flavin-containing monooxygenase (FMO) catalyses the flavin-dependent oxidation of ketones and cyclic ketones to esters and lactones, by using molecular oxygen and NAD(P)H.

CATH:  3.50.50.60
Gene Ontology:  GO:0016709|GO:0004497|GO:0050660
PubMed:  20015679|33588053

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-346 9.10e-88

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 269.81  E-value: 9.10e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSWR-NRYDSLQLFTPRPYSSLPGMALIDEKNEFPYKDEIATY 79
Cdd:COG2072    6 HVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRdNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGDEILAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  80 LEEYARHFQL--PIQLQTKVFKI--KKERDIFELHTPT-EILQTKKVIIATGGFQQPFIPSVSANLSSHVFQIHSSQYKS 154
Cdd:COG2072   86 LEAYADKFGLrrPIRFGTEVTSArwDEADGRWTVTTDDgETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHSADWRN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 155 PSQIPKEKVLVVGGGNSGMQIAVELAKTHE-VTLSISHPLTYLPLHLFRKSIFNWLEKLGL-LYAEVNTKRGKWFQKRK- 231
Cdd:COG2072  166 PVDLAGKRVLVVGTGASAVQIAPELARVAAhVTVFQRTPPWVLPRPNYDPERGRPANYLGLeAPPALNRRDARAWLRRLl 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 232 ------------DPIFGFEGK---------ELIRNGSIQL-QEKVVSASENNIMFQNGETYSAESIIWSTGFIQNYNWIE 289
Cdd:COG2072  246 raqvkdpelgllTPDYPPGCKrpllstdyyEALRRGNVELvTGGIERITEDGVVFADGTEHEVDVIVWATGFRADLPWLA 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446576541 290 IEKAVDENGL--PNHVKGI--SPVRGLYYIGLPWQSqRGSALICGVGKDAAYLLSEIKKID 346
Cdd:COG2072  326 PLDVRGRDGRsgPRAYLGVvvPGFPNLFFLGPNSPS-GHSSLTLGAERQARYIARLIAHMR 385
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-346 9.10e-88

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 269.81  E-value: 9.10e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSWR-NRYDSLQLFTPRPYSSLPGMALIDEKNEFPYKDEIATY 79
Cdd:COG2072    6 HVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRdNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGDEILAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  80 LEEYARHFQL--PIQLQTKVFKI--KKERDIFELHTPT-EILQTKKVIIATGGFQQPFIPSVSANLSSHVFQIHSSQYKS 154
Cdd:COG2072   86 LEAYADKFGLrrPIRFGTEVTSArwDEADGRWTVTTDDgETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHSADWRN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 155 PSQIPKEKVLVVGGGNSGMQIAVELAKTHE-VTLSISHPLTYLPLHLFRKSIFNWLEKLGL-LYAEVNTKRGKWFQKRK- 231
Cdd:COG2072  166 PVDLAGKRVLVVGTGASAVQIAPELARVAAhVTVFQRTPPWVLPRPNYDPERGRPANYLGLeAPPALNRRDARAWLRRLl 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 232 ------------DPIFGFEGK---------ELIRNGSIQL-QEKVVSASENNIMFQNGETYSAESIIWSTGFIQNYNWIE 289
Cdd:COG2072  246 raqvkdpelgllTPDYPPGCKrpllstdyyEALRRGNVELvTGGIERITEDGVVFADGTEHEVDVIVWATGFRADLPWLA 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446576541 290 IEKAVDENGL--PNHVKGI--SPVRGLYYIGLPWQSqRGSALICGVGKDAAYLLSEIKKID 346
Cdd:COG2072  326 PLDVRGRDGRsgPRAYLGVvvPGFPNLFFLGPNSPS-GHSSLTLGAERQARYIARLIAHMR 385
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
12-316 7.27e-44

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 152.76  E-value: 7.27e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   12 AGLTMGYYLKQEG-YNFLLLEAGNrVGDSWRNRYDSLQLFTPRPYS---SLPGMALIDE--------KNEFPYKDEIATY 79
Cdd:pfam13738   2 AGIGCAIALKKAGlEDYLILEKGN-IGNSFYRYPTHMTFFSPSFTSngfGIPDLNAISPgtspaftfNREHPSGNEYAEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   80 LEEYARHFQLPIQLQTKVFKIKKERDIFELHTPTEILQTKKVIIATGGFQQPFIPsvsaNLSSHVfqIHSSQYKSPSQIP 159
Cdd:pfam13738  81 LRRVADHFELPINLFEEVTSVKKEDDGFVVTTSKGTYQARYVIIATGEFDFPNKL----GVPELP--KHYSYVKDFHPYA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  160 KEKVLVVGGGNSGMQIAVELAKT-HEVTlsishpltylplhlfrksifnwleklgllyaeVNTKRGKWFQKRKDPIFGFE 238
Cdd:pfam13738 155 GQKVVVIGGYNSAVDAALELVRKgARVT--------------------------------VLYRGSEWEDRDSDPSYSLS 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  239 G------KELIRNGSIQL--QEKVVSASENN----IMFQNGETYSAESI-IWSTGFIQNYNWIE-IEKAVDENGLP---- 300
Cdd:pfam13738 203 PdtlnrlEELVKNGKIKAhfNAEVKEITEVDvsykVHTEDGRKVTSNDDpILATGYHPDLSFLKkGLFELDEDGRPvlte 282

                         330       340
                  ....*....|....*....|.
gi 446576541  301 -----NhvkgispVRGLYYIG 316
Cdd:pfam13738 283 etestN-------VPGLFLAG 296
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-319 5.15e-18

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 84.53  E-value: 5.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   2 KDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSW--------------RNR-------YDSLQLFTPRP---YSS 57
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWvytpksesdplsldPTRsivhssvYESLRTNLPREcmgYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  58 LPGMALIDEKNE----FPYKDEIATYLEEYARHFQLP--IQLQTKVFKIKKERDIFELHTPT-------EILQTkkVIIA 124
Cdd:PLN02172  91 FPFVPRFDDESRdsrrYPSHREVLAYLQDFAREFKIEemVRFETEVVRVEPVDGKWRVQSKNsggfskdEIFDA--VVVC 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 125 TGGFQQPFIPSVSANLSSHVFQIHSSQYKSPSQIPKEKVLVVGGGNSGMQIAVELAK-THEVtlsishpltylplHLFRK 203
Cdd:PLN02172 169 NGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKvAKEV-------------HIASR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 204 SifnwleklgllyAEVNTkrgkwFQKRKDPifgfegkelirNGSIQLQEKVVSASEN-NIMFQNGETYSAESIIWSTGFI 282
Cdd:PLN02172 236 A------------SESDT-----YEKLPVP-----------QNNLWMHSEIDTAHEDgSIVFKNGKVVYADTIVHCTGYK 287

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446576541 283 QNYNWIEIEK--AVDENGLPNHVKGISP---VRGLYYIGLPW 319
Cdd:PLN02172 288 YHFPFLETNGymRIDENRVEPLYKHVFPpalAPGLSFIGLPA 329
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 3-143 1.46e-03

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 40.20  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541    3 DLIIIGAGQAGLTMGYYLKQEGYNFLLLEagnrvgdswrnrydslQLFTPRPYSSLPGMALIDEKnefpykdeiaTYLEE 82
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKKTLLLE----------------QFDLPHSRGSSHGQSRIIRK----------AYPED 55

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446576541   83 Y-----ARHFQLPIQLQTKVFkikkerdiFELHTPTEILqtkkviiATGGFQQPFIPSVSANLSSH 143
Cdd:TIGR01377  56 FytpmmLECYQLWAQLEKEAG--------TKLHRQTGLL-------LLGPKENQFLKTIQATLSRH 106
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-346 9.10e-88

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 269.81  E-value: 9.10e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSWR-NRYDSLQLFTPRPYSSLPGMALIDEKNEFPYKDEIATY 79
Cdd:COG2072    6 HVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRdNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGDEILAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  80 LEEYARHFQL--PIQLQTKVFKI--KKERDIFELHTPT-EILQTKKVIIATGGFQQPFIPSVSANLSSHVFQIHSSQYKS 154
Cdd:COG2072   86 LEAYADKFGLrrPIRFGTEVTSArwDEADGRWTVTTDDgETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHSADWRN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 155 PSQIPKEKVLVVGGGNSGMQIAVELAKTHE-VTLSISHPLTYLPLHLFRKSIFNWLEKLGL-LYAEVNTKRGKWFQKRK- 231
Cdd:COG2072  166 PVDLAGKRVLVVGTGASAVQIAPELARVAAhVTVFQRTPPWVLPRPNYDPERGRPANYLGLeAPPALNRRDARAWLRRLl 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 232 ------------DPIFGFEGK---------ELIRNGSIQL-QEKVVSASENNIMFQNGETYSAESIIWSTGFIQNYNWIE 289
Cdd:COG2072  246 raqvkdpelgllTPDYPPGCKrpllstdyyEALRRGNVELvTGGIERITEDGVVFADGTEHEVDVIVWATGFRADLPWLA 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446576541 290 IEKAVDENGL--PNHVKGI--SPVRGLYYIGLPWQSqRGSALICGVGKDAAYLLSEIKKID 346
Cdd:COG2072  326 PLDVRGRDGRsgPRAYLGVvvPGFPNLFFLGPNSPS-GHSSLTLGAERQARYIARLIAHMR 385
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
12-316 7.27e-44

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 152.76  E-value: 7.27e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   12 AGLTMGYYLKQEG-YNFLLLEAGNrVGDSWRNRYDSLQLFTPRPYS---SLPGMALIDE--------KNEFPYKDEIATY 79
Cdd:pfam13738   2 AGIGCAIALKKAGlEDYLILEKGN-IGNSFYRYPTHMTFFSPSFTSngfGIPDLNAISPgtspaftfNREHPSGNEYAEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   80 LEEYARHFQLPIQLQTKVFKIKKERDIFELHTPTEILQTKKVIIATGGFQQPFIPsvsaNLSSHVfqIHSSQYKSPSQIP 159
Cdd:pfam13738  81 LRRVADHFELPINLFEEVTSVKKEDDGFVVTTSKGTYQARYVIIATGEFDFPNKL----GVPELP--KHYSYVKDFHPYA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  160 KEKVLVVGGGNSGMQIAVELAKT-HEVTlsishpltylplhlfrksifnwleklgllyaeVNTKRGKWFQKRKDPIFGFE 238
Cdd:pfam13738 155 GQKVVVIGGYNSAVDAALELVRKgARVT--------------------------------VLYRGSEWEDRDSDPSYSLS 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  239 G------KELIRNGSIQL--QEKVVSASENN----IMFQNGETYSAESI-IWSTGFIQNYNWIE-IEKAVDENGLP---- 300
Cdd:pfam13738 203 PdtlnrlEELVKNGKIKAhfNAEVKEITEVDvsykVHTEDGRKVTSNDDpILATGYHPDLSFLKkGLFELDEDGRPvlte 282

                         330       340
                  ....*....|....*....|.
gi 446576541  301 -----NhvkgispVRGLYYIG 316
Cdd:pfam13738 283 etestN-------VPGLFLAG 296
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-187 2.22e-18

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 84.02  E-value: 2.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   3 DLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGdswrnrydSLQLFTP-RPYsslPGmalidekneFPYK---DEIAT 78
Cdd:COG0492    2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEPGG--------QLATTKEiENY---PG---------FPEGisgPELAE 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  79 YLEEYARHFQLPIQLQTkVFKIKKERDIFELHTPT-EILQTKKVIIATG-GFQQPFIPSVSANLSSHVF---QIHSSQYK 153
Cdd:COG0492   62 RLREQAERFGAEILLEE-VTSVDKDDGPFRVTTDDgTEYEAKAVIIATGaGPRKLGLPGEEEFEGRGVSycaTCDGFFFR 140

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446576541 154 spsqipKEKVLVVGGGNSGMQIAVELAK-THEVTL 187
Cdd:COG0492  141 ------GKDVVVVGGGDSALEEALYLTKfASKVTL 169
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-319 5.15e-18

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 84.53  E-value: 5.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   2 KDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSW--------------RNR-------YDSLQLFTPRP---YSS 57
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWvytpksesdplsldPTRsivhssvYESLRTNLPREcmgYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  58 LPGMALIDEKNE----FPYKDEIATYLEEYARHFQLP--IQLQTKVFKIKKERDIFELHTPT-------EILQTkkVIIA 124
Cdd:PLN02172  91 FPFVPRFDDESRdsrrYPSHREVLAYLQDFAREFKIEemVRFETEVVRVEPVDGKWRVQSKNsggfskdEIFDA--VVVC 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 125 TGGFQQPFIPSVSANLSSHVFQIHSSQYKSPSQIPKEKVLVVGGGNSGMQIAVELAK-THEVtlsishpltylplHLFRK 203
Cdd:PLN02172 169 NGHYTEPNVAHIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKvAKEV-------------HIASR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541 204 SifnwleklgllyAEVNTkrgkwFQKRKDPifgfegkelirNGSIQLQEKVVSASEN-NIMFQNGETYSAESIIWSTGFI 282
Cdd:PLN02172 236 A------------SESDT-----YEKLPVP-----------QNNLWMHSEIDTAHEDgSIVFKNGKVVYADTIVHCTGYK 287

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446576541 283 QNYNWIEIEK--AVDENGLPNHVKGISP---VRGLYYIGLPW 319
Cdd:PLN02172 288 YHFPFLETNGymRIDENRVEPLYKHVFPpalAPGLSFIGLPA 329
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-298 3.65e-17

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 80.83  E-value: 3.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541    2 KDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRvgdswrnrydsLQLFTPRPYSSLPGMAliDEKNEFPYKDEIATYLE 81
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGT-----------CPYGGCVLSKALLGAA--EAPEIASLWADLYKRKE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   82 EYARHFQLPIQ--LQTKVFKI-KKERDIFELHTP---TEILQTKKVIIATGGfqQPF---IPSVSANLSSHVFQIHSSQY 152
Cdd:pfam07992  68 EVVKKLNNGIEvlLGTEVVSIdPGAKKVVLEELVdgdGETITYDRLVIATGA--RPRlppIPGVELNVGFLVRTLDSAEA 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  153 KSPSQIPKeKVLVVGGGNSGMQIAVELAK-THEVTLsishpltylplhlfrksifnwLEklgllyaevntkRGKWFQKRK 231
Cdd:pfam07992 146 LRLKLLPK-RVVVVGGGYIGVELAAALAKlGKEVTL---------------------IE------------ALDRLLRAF 191

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446576541  232 DPIFG-FEGKELIRNG-SIQLQEKVVSASENNI----MFQNGETYSAESIIWSTGFIQNYNWIEIEK-AVDENG 298
Cdd:pfam07992 192 DEEISaALEKALEKNGvEVRLGTSVKEIIGDGDgvevILKDGTEIDADLVVVAIGRRPNTELLEAAGlELDERG 265
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-289 1.57e-16

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 80.59  E-value: 1.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541    2 KDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSWR----------NRYDSLQLFTPRPYSSLPGMALIDEKNEFP 71
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRftenveegraSIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   72 YKDEIATYLEEYARHFQL--PIQLQTKVFKIKKERDI-----FELHTPTEILQTKK----VIIATGGFQQPFIPsvsanL 140
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLlkYIQFKTTVCSVKKRPDFstsgqWEVVTEHEGKQESAvfdaVMVCTGHHTNPHLP-----L 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  141 SS----HVFQ---IHSSQYKSPSQIPKEKVLVVGGGNSGMQIAVELAKTHE-VTLSISH-------------P------- 192
Cdd:pfam00743 157 ESfpgiEKFKgqyFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAqVFLSTRRgswvlsrvsdhgyPwdmlfst 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  193 -LTYLPLHLFRKSIFNWLeklgllyaeVNTKRGKWFQ------------KRKDPIFGFEGKELIRNGSIQLQEKVVSASE 259
Cdd:pfam00743 237 rFTSFLRNILPTSISNWL---------MEKQMNRRFNhenyglkpknraLSKEPVVNDDLPNRILCGAVKVKPNVKEFTE 307

                         330       340       350
                  ....*....|....*....|....*....|.
gi 446576541  260 NNIMFQNGETYSA-ESIIWSTGFIQNYNWIE 289
Cdd:pfam00743 308 TSAIFEDGTVEEDiDVVIFATGYTFAFPFLE 338
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 67-207 5.78e-09

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 56.82  E-value: 5.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   67 KNEFPYKDEIATYLEEYARHFQLPIQLQTKVFKIK----KERDIFELHTP-----TEILQTKKVIIATGGfqQPFIPSVs 137
Cdd:pfam13434  88 ETFFPSRREFNDYLQWAASHLPNRLRFGQEVESVEpdaeRGEPLLRVRVRdadgeETTFLARNLVLGTGG--EPYIPEC- 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446576541  138 ANLSSHVFqiHSSQY--KSPSQIPKEKVLVVGGGNSGMQIAVELAK---THEVTLSISH----PLTYLPlhlFRKSIFN 207
Cdd:pfam13434 165 ARGGERVF--HSSEYleRIDRLAAKKRIAVVGSGQSAAEIFRDLLRrgpAYELTWVTRSpnffPLDDSP---FVNEIFS 238
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-127 1.07e-08

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 56.21  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   5 IIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG-------------------DSWRNRY--------DSLQLFTPRpyss 57
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGrkilisgggrcnftnseplPEFLNYYggnphflkSALSRFTPE---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  58 lpgmALID----------EKNE---FPYKD---EIATYLEEYARHFQLPIQLQTKVFKIKKERDIFELHTPT-EILQTKK 120
Cdd:COG2081   77 ----DLIAffeglgietkEESSgrvFPDSSkasDILRALLAELREAGVEIRLRTRVTGIEKEDGGFGVETPDgETVRADA 152


                 ....*..
gi 446576541 121 VIIATGG 127
Cdd:COG2081  153 VVLATGG 159
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-37 6.12e-08

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 54.07  E-value: 6.12e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:COG1232    1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVG 37
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
1-37 4.11e-07

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 51.46  E-value: 4.11e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:COG1231    7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVG 43
HI0933_like pfam03486
HI0933-like protein;
2-127 1.02e-06

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 49.89  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541    2 KDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGDSWR----------NRYDSLQLFTPRP-------YSSL---PGM 61
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILisgggrcnvtNLSEEPDNFLSRYpgnpkflKSALsrfTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   62 ALID--EKNEFPYKDE--------------IATYLEEYARHFQLPIQLQTKVFKIKKERD-IFELHTPTEILQTKKVIIA 124
Cdd:pfam03486  81 DFIAffESLGVPLKEEdhgrlfpdsdkasdIVDALLNELKELGVKIRLRTRVLSVEKDDDgRFRVKTGGEELEADSLVLA 160


                  ...
gi 446576541  125 TGG 127
Cdd:pfam03486 161 TGG 163
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-37 1.07e-06

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 45.60  E-value: 1.07e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 446576541    6 IIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLG 32
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-42 1.27e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.44  E-value: 1.27e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGnRVGD--SWRN 42
Cdd:COG0665    2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERG-RPGSgaSGRN 44
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
1-128 3.14e-05

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 45.52  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQ-EGYNFLLLEAGNRVGD--SWRN-------------------------RYD--SLQL- 49
Cdd:COG0579    4 MYDVVIIGAGIVGLALARELSRyEDLKVLVLEKEDDVAQesSGNNsgvihaglyytpgslkarlcvegneLFYelCRELg 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  50 FTPRPYSSL------------------------PGMALIDeknefpyKDEI-------------ATY------------- 79
Cdd:COG0579   84 IPFKRCGKLvvatgeeevafleklyergkangvPGLEILD-------REELrelepllsdegvaALYspstgivdpgalt 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446576541  80 --LEEYARHFQLPIQLQTKVFKIKKERDIFELHTPTEILQTKKVIIATGGF 128
Cdd:COG0579  157 raLAENAEANGVELLLNTEVTGIEREGDGWEVTTNGGTIRARFVINAAGLY 207
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 3-42 3.44e-05

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 45.08  E-value: 3.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446576541    3 DLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVGD--SWRN 42
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSgaSGRN 42
PRK07208 PRK07208
hypothetical protein; Provisional
 1-37 3.99e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 45.27  E-value: 3.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:PRK07208   4 KKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVG 40
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-37 6.07e-05

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 44.46  E-value: 6.07e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:COG1233    3 MYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPG 39
PLN02976 PLN02976
amine oxidase
 2-37 7.76e-05

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 44.86  E-value: 7.76e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446576541    2 KDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:PLN02976  694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIG 729
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 2-37 4.28e-04

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 41.76  E-value: 4.28e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446576541   2 KDLIIIGAGQAGLTMGYYLKQEGYNF--LLLEAGNRVG 37
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDAdiTLLEASDRLG 38
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
154-187 5.99e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 41.77  E-value: 5.99e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 446576541 154 SPSQIPKEK-VLVVGGGNSGMQIAVELAKT-HEVTL 187
Cdd:COG1148  133 EPIKVPVNKrALVIGGGIAGMTAALELAEQgYEVYL 168
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 113-180 7.27e-04

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 41.23  E-value: 7.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446576541 113 TEILQTKKVIIATGGfqQPFIPSVSANLSSHVfqIHSSQYKSPSQIPKeKVLVVGGGNsgmqIAVELA 180
Cdd:COG1249  126 GETLTADHIVIATGS--RPRVPPIPGLDEVRV--LTSDEALELEELPK-SLVVIGGGY----IGLEFA 184
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-37 9.27e-04

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 40.63  E-value: 9.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446576541   1 MKDLIIIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:COG3380    3 MPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVG 39
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 3-143 1.46e-03

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 40.20  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541    3 DLIIIGAGQAGLTMGYYLKQEGYNFLLLEagnrvgdswrnrydslQLFTPRPYSSLPGMALIDEKnefpykdeiaTYLEE 82
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKKTLLLE----------------QFDLPHSRGSSHGQSRIIRK----------AYPED 55

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446576541   83 Y-----ARHFQLPIQLQTKVFkikkerdiFELHTPTEILqtkkviiATGGFQQPFIPSVSANLSSH 143
Cdd:TIGR01377  56 FytpmmLECYQLWAQLEKEAG--------TKLHRQTGLL-------LLGPKENQFLKTIQATLSRH 106
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
81-187 2.81e-03

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 39.13  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446576541  81 EEYARHFQLPIQLQTKVFKIKKERDIfeLHTPTEILQTKKVIIATGGfqQPFIPSVSANlsSHVFQIHSSQYKSPSQIP- 159
Cdd:PRK04965  65 GEFAEQFNLRLFPHTWVTDIDAEAQV--VKSQGNQWQYDKLVLATGA--SAFVPPIPGR--ELMLTLNSQQEYRAAETQl 138

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446576541 160 --KEKVLVVGGGNSGMQIAVELAKT-HEVTL 187
Cdd:PRK04965 139 rdAQRVLVVGGGLIGTELAMDLCRAgKAVTL 169
PLN02576 PLN02576
protoporphyrinogen oxidase
 2-37 4.66e-03

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 38.84  E-value: 4.66e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446576541   2 KDLIIIGAGQAGLTMGYYLK-QEGYNFLLLEAGNRVG 37
Cdd:PLN02576  13 KDVAVVGAGVSGLAAAYALAsKHGVNVLVTEARDRVG 49
PRK07233 PRK07233
hypothetical protein; Provisional
 6-37 4.70e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 38.71  E-value: 4.70e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 446576541   6 IIGAGQAGLTMGYYLKQEGYNFLLLEAGNRVG 37
Cdd:PRK07233   4 IVGGGIAGLAAAYRLAKRGHEVTVFEADDQLG 35
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 1-59 6.25e-03

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 38.28  E-value: 6.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446576541    1 MKDLIIIGAGQAGLTMGYYLKQE----GYNFLLLEAGNRVGDSWRNRYDSLQLFTPRPYSSLP 59
Cdd:TIGR00562   2 KKHVVIIGGGISGLCAAYYLEKEipelPVELTLVEASDRVGGKIQTVKEDGYLIERGPDSFLE 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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