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Conserved domains on  [gi|446579854|ref|WP_000657200|]
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MULTISPECIES: molybdenum cofactor biosynthesis protein MoaE [Acinetobacter]

Protein Classification

molybdenum cofactor biosynthesis protein MoaE( domain architecture ID 10001056)

molybdenum cofactor biosynthesis protein MoaE serves as the catalytic subunit of the molybdopterin synthase complex, which catalyzes the conversion of precursor Z into molybdopterin

CATH:  3.90.1170.40
EC:  2.8.1.12
Gene Ontology:  GO:0006777|GO:0030366
PubMed:  35744859
SCOP:  4001136

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 5-140 6.37e-46

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 146.86  E-value: 6.37e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854   5 ARIQEQALSLDTFdpIQSF----PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVV 80
Cdd:COG0314    4 VRVTEEPFDLAAE--LAALrasdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  81 HRIGYLDVGETAIIAIAYAAHRREAFQACEEAVERVKHEVPVFKEEFFTDGtSHYVEGCC 140
Cdd:COG0314   82 HRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARS 140
 
Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 5-140 6.37e-46

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 146.86  E-value: 6.37e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854   5 ARIQEQALSLDTFdpIQSF----PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVV 80
Cdd:COG0314    4 VRVTEEPFDLAAE--LAALrasdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  81 HRIGYLDVGETAIIAIAYAAHRREAFQACEEAVERVKHEVPVFKEEFFTDGtSHYVEGCC 140
Cdd:COG0314   82 HRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARS 140
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 24-131 3.66e-41

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 134.18  E-value: 3.66e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  24 PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYLDVGETAIIAIAYAAHRR 103
Cdd:cd00756   13 PEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAIVLVAVSSPHRK 92

                         90       100
                 ....*....|....*....|....*...
gi 446579854 104 EAFQACEEAVERVKHEVPVFKEEFFTDG 131
Cdd:cd00756   93 EAFEACEFLIDRLKHRAPIWKKEIFEGG 120
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 7-119 7.91e-37

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 122.56  E-value: 7.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854    7 IQEQALSLDTFDPIQSFPECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYL 86
Cdd:pfam02391   1 ITEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446579854   87 DVGETAIIAIAYAAHRREAFQACEEAVERVKHE 119
Cdd:pfam02391  81 PVGEAIVLVAVSSPHRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 24-131 3.61e-27

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 98.22  E-value: 3.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  24 PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYLDVGETAIIAIAYAAHRR 103
Cdd:PLN02390   2 PQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHRA 81

                         90       100
                 ....*....|....*....|....*...
gi 446579854 104 EAFQACEEAVERVKHEVPVFKEEFFTDG 131
Cdd:PLN02390  82 DALDACKFLIDELKASVPIWKKEVYDDG 109
 
Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 5-140 6.37e-46

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 146.86  E-value: 6.37e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854   5 ARIQEQALSLDTFdpIQSF----PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVV 80
Cdd:COG0314    4 VRVTEEPFDLAAE--LAALrasdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  81 HRIGYLDVGETAIIAIAYAAHRREAFQACEEAVERVKHEVPVFKEEFFTDGtSHYVEGCC 140
Cdd:COG0314   82 HRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARS 140
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 24-131 3.66e-41

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 134.18  E-value: 3.66e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  24 PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYLDVGETAIIAIAYAAHRR 103
Cdd:cd00756   13 PEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAIVLVAVSSPHRK 92

                         90       100
                 ....*....|....*....|....*...
gi 446579854 104 EAFQACEEAVERVKHEVPVFKEEFFTDG 131
Cdd:cd00756   93 EAFEACEFLIDRLKHRAPIWKKEIFEGG 120
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 7-119 7.91e-37

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 122.56  E-value: 7.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854    7 IQEQALSLDTFDPIQSFPECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYL 86
Cdd:pfam02391   1 ITEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446579854   87 DVGETAIIAIAYAAHRREAFQACEEAVERVKHE 119
Cdd:pfam02391  81 PVGEAIVLVAVSSPHRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 24-131 3.61e-27

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 98.22  E-value: 3.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  24 PECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYLDVGETAIIAIAYAAHRR 103
Cdd:PLN02390   2 PQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHRA 81

                         90       100
                 ....*....|....*....|....*...
gi 446579854 104 EAFQACEEAVERVKHEVPVFKEEFFTDG 131
Cdd:PLN02390  82 DALDACKFLIDELKASVPIWKKEVYDDG 109
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 23-131 6.14e-17

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 75.42  E-value: 6.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  23 FPECGGIDIFMGTVRNH--HEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYLDVGETAIIAIAYAA 100
Cdd:PRK14493 156 ADKAGAIATFTGRVRAKedADDEPTEYLEFEKYDGVADERMAAIREELKQRDGVFEVLLHHRTGVIEAGEDIVFVVVLAG 235

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446579854 101 HRREAFQACEEAVERVKHEVPVFKEEFFTDG 131
Cdd:PRK14493 236 HRQEAFRAVSDGIDRLKDEVPIFKKEVTVDE 266
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
25-137 9.44e-15

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 67.08  E-value: 9.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446579854  25 ECGGIDIFMGTVRNHHEGKAVKALKYTSYKPLAEKMIREIELEIEKKYQVSYVRVVHRIGYLDVGETAIIAIAYAAHRRE 104
Cdd:PRK10678  27 EDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSAHRSS 106

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446579854 105 AFQACEEAVERVKHEVPVFKEEFFTDGtSHYVE 137
Cdd:PRK10678 107 AFEAGQFIMDYLKTRAPFWKREATPEG-DRWVE 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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