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Conserved domains on  [gi|446581644|ref|WP_000658990|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-134 2.01e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.56  E-value: 2.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644   3 EILREIGMIARALDSISNIEFKEYELTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESN 82
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446581644  83 KKIKKLFPTEKGKNVYPFIKRENDYSNTVALEGFSETEAETISNLLQRVRKN 134
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-134 2.01e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.56  E-value: 2.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644   3 EILREIGMIARALDSISNIEFKEYELTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESN 82
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446581644  83 KKIKKLFPTEKGKNVYPFIKRENDYSNTVALEGFSETEAETISNLLQRVRKN 134
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-120 1.52e-16

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 70.32  E-value: 1.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644    22 EFKEYELTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIKKLFPTEKGKNVYPFI 101
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQL 81

                           90
                   ....*....|....*....
gi 446581644   102 KRENDYSNTVALEGFSETE 120
Cdd:smart00347  82 LEARSETLAELLAGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-86 8.13e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 54.09  E-value: 8.13e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446581644   28 LTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIK 86
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 24-135 3.06e-04

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 38.45  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644  24 KEYELTKGQYLYLVRICE-NPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIKKLFPTEKGKnvyPFIK 102
Cdd:PRK03573  25 KPLELTQTHWVTLHNIHQlPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAE---PLIS 101

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446581644 103 RENDYSNTV---ALEGFSETEAETISNLLQRVRKNI 135
Cdd:PRK03573 102 EVEAVINKTraeILHGISAEEIEQLITLIAKLEKNI 137
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-134 2.01e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 86.56  E-value: 2.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644   3 EILREIGMIARALDSISNIEFKEYELTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESN 82
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446581644  83 KKIKKLFPTEKGKNVYPFIKRENDYSNTVALEGFSETEAETISNLLQRVRKN 134
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-120 1.52e-16

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 70.32  E-value: 1.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644    22 EFKEYELTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIKKLFPTEKGKNVYPFI 101
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQL 81

                           90
                   ....*....|....*....
gi 446581644   102 KRENDYSNTVALEGFSETE 120
Cdd:smart00347  82 LEARSETLAELLAGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-86 8.13e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 54.09  E-value: 8.13e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446581644   28 LTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIK 86
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-85 9.45e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.73  E-value: 9.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446581644   28 LTKGQYLYLVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKI 85
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 24-135 3.06e-04

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 38.45  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446581644  24 KEYELTKGQYLYLVRICE-NPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIKKLFPTEKGKnvyPFIK 102
Cdd:PRK03573  25 KPLELTQTHWVTLHNIHQlPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAE---PLIS 101

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446581644 103 RENDYSNTV---ALEGFSETEAETISNLLQRVRKNI 135
Cdd:PRK03573 102 EVEAVINKTraeILHGISAEEIEQLITLIAKLEKNI 137
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
36-84 4.42e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.32  E-value: 4.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446581644  36 LVRICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKK 84
Cdd:COG3398  103 LLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVR 151
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 41-96 1.04e-03

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 37.42  E-value: 1.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446581644  41 ENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFIEKKEDESNKKIKKLFPTEKGKN 96
Cdd:PRK10870  68 ENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHE 123
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
39-74 6.51e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 32.79  E-value: 6.51e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446581644   39 ICENPGIIQEKLSEMIKVDRTTAARAIKKLELNGFI 74
Cdd:pfam13412  10 LQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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