|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-377 |
2.73e-91 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 279.09 E-value: 2.73e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAV 172
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVTVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELdLMAAASNFLLCYAI 252
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER-GISNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 253 FLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVAN 332
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446582902 333 SLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALY 377
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-379 |
3.91e-42 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 151.57 E-value: 3.91e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAV 172
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVTVPPVIRHADGSKPNLGFAA-----MFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASN-- 245
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSglrllLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIgl 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 246 FLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEP 325
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446582902 326 HKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYAV 379
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-345 |
1.14e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 133.56 E-value: 1.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPiYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLC 169
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 170 SAVAALGIVLSLIVtVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLM--AAASNFL 247
Cdd:COG2814 171 AVLALLALLLLLRL-LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLsaSAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 248 LCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHK 327
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....*...
gi 446582902 328 IGVANSLFFNAMDAGMAI 345
Cdd:COG2814 330 RGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-347 |
1.19e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.35 E-value: 1.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAV 172
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVTVPPVIRHADGSK-----PNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDL-MAAASNF 246
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEearlsLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLsALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 247 LLCYAIFLMICRTFTGNICDKKGPK---YVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSV 323
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 446582902 324 EPHKIGVANSLFFNAMDAGMAIGA 347
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
10-378 |
2.15e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 106.12 E-value: 2.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIyIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIG--LNMARWNAFTAAFW 167
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGglLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 168 LCSAVAALGIVLSLIVTVPPViRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASNFL 247
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKA-KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 248 LCYAIFLMICRT--FTGNICDKK-GPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVE 324
Cdd:cd17474 239 LFAGWSVLLALGslFVGRLLKKRfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446582902 325 PHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYA 378
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-373 |
8.49e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 101.47 E-value: 8.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFYVLLTLLPIyIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITAL 90
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 91 YPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLcS 170
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA-I 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 171 AVAALGIVLSLIVTVPPVIRHADGSKPNLG-FAAMFDRAALPFALV-TFFMTFSYAGVSAFLALYARELDLM--AAASNF 246
Cdd:cd17324 160 AVLALLAALLLWRLLPSLPPKKPGSLGLLSsLLLLLRNPRLRLAYLiTFLLFGGFFALYTYLAPFLTDVPGFssSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 247 LLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPH 326
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446582902 327 KiGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLA 373
Cdd:cd17324 320 R-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-376 |
1.10e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 95.72 E-value: 1.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPiYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLC 169
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 170 SAVAALGIVLSLIVTV-PPVIRHADGSKPNLGFAAMF-DRAALPFALVTFFMTFSYAGVSAFLALYAREL--DLMAAASN 245
Cdd:COG2223 166 GILLLVVAVLAWLFLRdPPAGAAAAAKASLRDQLEALrDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfgLSAATAGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 246 FLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYG-SVTPVFQTQIISSVE 324
Cdd:COG2223 246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALgGGNGAVFALVPDIFP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446582902 325 PHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVG-YRMIYVAGAVLVVLAGAL 376
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-384 |
1.26e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 92.24 E-value: 1.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 3 EKLWTKDFWAITIVSFIIFFVFYVLLTLLPI---YIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVL 79
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVaapPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 80 SSLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARW 159
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 160 NAFTAAFWLCSAVAALGIVLSLIVtvppvirhadgskpnlgfaamfdraalpFALVTFFMTFSYAGVSAFLALYARELDL 239
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWL----------------------------LALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 240 M--AAASNFLLCYAIFLMICRTFTGNICDK--KGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVF 315
Cdd:COG2271 213 LslAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446582902 316 QTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYAVQMKKR 384
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-380 |
2.97e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 91.52 E-value: 2.97e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCH-----SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTA 164
Cdd:cd06173 80 VLALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 165 AFWLCSAVAALGIVLSLIVTVPPVIRHADGSKPNLGFAA------MFDRAALPFALVTFFMTFSYAGVSAFLALYARE-L 237
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLReglrylRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 238 DLMAAASNFLL-CYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQ 316
Cdd:cd06173 240 GGGAAGYGLLLaAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446582902 317 TQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYAVQ 380
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-378 |
3.16e-20 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 91.13 E-value: 3.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITAL 90
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 91 YPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNaFTAAFWLCS 170
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-FRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 171 AVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMF---DRAALPFALVTFFMTFSYAGVSAFLALYARELDL--MAAASN 245
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIvlrDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlgESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 246 FLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEP 325
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446582902 326 HKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYA 378
Cdd:cd17329 321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-182 |
1.23e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.56 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 TALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFW 167
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*
gi 446582902 168 LCSAVAALGIVLSLI 182
Cdd:cd17325 359 AAAALLLLAAVLFLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-384 |
4.78e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 87.99 E-value: 4.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 1 MKEKLWTKDFWAITIVSFIIFFVFYVLLTLLPiYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLS 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 81 SLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGeGISFFSLAMGLAMVVGPWIGLNMARWN 160
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 161 ---AFTAAFWLCSAVAALGIVLSLIVTVPPVIRHAD--GSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYAR 235
Cdd:COG0738 159 lslSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEeaAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 236 ELDLM--AAASNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTP 313
Cdd:COG0738 239 DVLGLseATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446582902 314 VFQTQIISSVePHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYAVQMKKR 384
Cdd:COG0738 319 TIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-377 |
2.05e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.86 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIG--LNMARWNAFTAAFWLCS 170
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGgiLASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 171 AVAALGIVLSLIVTVPPVIRHADGSKPNLG-------FAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLM--A 241
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSksvlkllKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsvA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 242 AASNFLLCYAIFLMICRTFTGNICDKK-GPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQII 320
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446582902 321 SSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMM-VESVGYRMIYVAGAVLVVLAGALY 377
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-358 |
5.89e-16 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 78.77 E-value: 5.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 35 IADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVI 114
Cdd:cd17503 22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 115 TTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAVAALGIVLSlivtvpPVIRhadg 194
Cdd:cd17503 102 IPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA------PLLD---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 195 skpnlgFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARE-LDLMAAASNFLLC-YAIFLMICRTFTGNICDKKGPKY 272
Cdd:cd17503 172 ------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLApGGLASAILSPLVGRLLDKFGPRL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 273 VVYPCLLAFTIGLVALGYTN---GSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFI 349
Cdd:cd17503 246 LLLAGLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTAL 325
|
....*....
gi 446582902 350 MGMMVESVG 358
Cdd:cd17503 326 LATLLTNRT 334
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
8-384 |
8.01e-16 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 78.39 E-value: 8.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVL---LTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILV------ 78
Cdd:PRK05122 12 RLTLRIVSIVMFTFISYLTIglpLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVfglcgc 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 79 -LSSLAFLVITALYPVCH-SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNM 156
Cdd:PRK05122 92 aLSGLLYLLAGLLAAWPVlSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 157 ARWNAFTAAFWLCSAVAALGIVLSL-IVTVPPVirhadgSKPNLGFAAMFDRAAlPFALVTFFMTFSYAGVSAFLALYAR 235
Cdd:PRK05122 172 YHWGGLAGLGLLIMLLALLGLLLARpRPAVPPV------KGERLPFRRVLGRVW-PYGMGLALASIGFGTIATFITLYYA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 236 ELDLMAAASNfLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVF 315
Cdd:PRK05122 245 ARGWDGAALA-LTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPAL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446582902 316 QTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALyAVQMKKR 384
Cdd:PRK05122 324 GVEAVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLAL-TWLLYRR 391
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-381 |
1.77e-14 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 74.18 E-value: 1.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 15 IVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITAL-YPV 93
Cdd:cd17490 3 IIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLiMIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 94 CHSIESLLFIRVLHGITFGviTTVKGTIS-ARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAV 172
Cdd:cd17490 82 FPSPWGLLIARFLSGIAAA--TWVSFTVLyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVTVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTF-SYAGVSAFLALYAREL-----DLMAAASNF 246
Cdd:cd17490 160 GVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMiTFSTTFGFTPLIAKQLgassfQLGLLSIIY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 247 LLCYAIFLMICRTFtgnICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPH 326
Cdd:cd17490 240 LLPNALASLLSGTL---FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAE 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446582902 327 KIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYAVQM 381
Cdd:cd17490 317 QRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-376 |
4.82e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.59 E-value: 4.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIyIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSL-RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAftAAFWLCSAV 172
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVTVPPVIRHADGSKPNLGFAamfdRAALPFALVTFFMTFSYAGVSAFLALYARELDL-MAAASNFLLCYA 251
Cdd:cd17477 158 LLLALVPLLLTRRAAPEIEEAESISLRRLL----RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLsVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 252 IFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYT-NGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGV 330
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446582902 331 ANSLFFNAMDAGMAIGAFIMGMMVESVG-YRMIYVAGAVLVVLAGAL 376
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGpHGLFLFLAAVALLFLLFL 360
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
13-376 |
1.11e-13 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 71.81 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIrpfaGQWVGKYSN-----KKILVLSSLAFLVI 87
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVV----SQWLGRLSDrggdrKPLILLALLAGALG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 TALYPVCHSIESLLFIR-VLHGITFGVITTVKGtiSARLIPASRRGEGISFFSLAM----GLAMVVGPWIGLNMARWNAF 162
Cdd:cd17471 77 YLLFAFLRNYWVLLLVGvVLLSLGAAAFPQLFA--LAREYADRSSGRDATLFNSVLraafSLAWVIGPPLAFLLLDVLGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 163 TAAFWLCSAVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALY-ARELDLMA 241
Cdd:cd17471 155 TGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYvTNELGGSE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 242 AASNFLLCYA----IFLMIcrtFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVT----P 313
Cdd:cd17471 235 SWVGLLFGLAaaleIPIML---LAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAglgiS 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446582902 314 VFQTQIissvePHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGAL 376
Cdd:cd17471 312 YFQDLM-----PGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
1-179 |
5.91e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.52 E-value: 5.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 1 MKEKLWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGK-YSNKKILVL 79
Cdd:cd17474 191 LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 80 SSLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARW 159
Cdd:cd17474 271 GLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
170 180
....*....|....*....|
gi 446582902 160 NAFTAAFWLCSAVAALGIVL 179
Cdd:cd17474 351 FGLSAPFLVGAAIALAAAVL 370
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
12-385 |
6.61e-13 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 69.32 E-value: 6.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 12 AITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLA------FL 85
Cdd:PRK12382 19 RIAFAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLAcglaglAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 86 VITALYPVCHSIESLLFI--RVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFt 163
Cdd:PRK12382 99 LLAAILPVSAPFKFALLVvgRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGF- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 164 aafwlcSAVAALGIVLSLIV-----TVPPVIRHAdGSKPNLGFAAmfdRAALPFALVTFFMTFSYAGVSAFLALYARELD 238
Cdd:PRK12382 178 ------AALALTTMVLPLLAwafngTVRKVPAHA-GERPSLWSVV---GLIWKPGLGLALQGVGFAVIGTFVSLYFASKG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 239 lMAAASNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQ 318
Cdd:PRK12382 248 -WAMAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446582902 319 IISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLaGALYAVQMKKRG 385
Cdd:PRK12382 327 VVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVL-GIIVTILSFRRG 392
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-373 |
6.90e-13 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 69.14 E-value: 6.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 15 IVSFIIFFVFYVLLTLLPIYIADR--LHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRrGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAV 172
Cdd:cd17330 83 LSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEER-AKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVtVPPVIRhadgskpnlgfaamfdraalpFALVTFFMTFSYAGVSAFLALYARELDLMAAA--SNFLLCY 250
Cdd:cd17330 162 ALLNLVLVLFF-LPPLRR---------------------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSqiGLLLALV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 251 AIFLMICRTFTGNICDKK-GPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIG 329
Cdd:cd17330 220 GIAGILAQLLLIPRLAKRlGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQG 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446582902 330 VANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLA 373
Cdd:cd17330 300 KAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-376 |
2.39e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 67.58 E-value: 2.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIyIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYP 92
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPT-IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 93 VCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAV 172
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSlivtvppvirhadgskpnlgfaamfdRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAA--ASNFLLCY 250
Cdd:cd17321 160 GLVALLLA--------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPlqAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 251 AIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVAL---GYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHK 327
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLallGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEK 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446582902 328 IGVANSLFFNAMDAGMAIGAFIMGMMVESV-----------------------GYRMIYVAGAVLVVLAGAL 376
Cdd:cd17321 294 AGAASGILNTARQLGGALGVALLGALLTAGlsanlgdsgvaallsaaaaafaaGFHLAFLVAAALALLAALL 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-359 |
1.20e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.69 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 1 MKEKLWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKK----- 75
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrp 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 76 ILVLSSLAFLVITALYPVCHSIES------LLFIRVLHGITFGVITTVKGTISARLIPASR-RGEGISFFSLAMGLAMVV 148
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 149 GPWIGLNMARW------NAFTAAFWLCSAVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMF-DRAALPFALVTFFMTF 221
Cdd:COG2211 163 ASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLkNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 222 SYAGVSAFLALYAREL--DLMAAASNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGS--IMM 297
Cdd:COG2211 243 ALALVAALLLYYFKYVlgLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446582902 298 IISGGLIGIGYGSVTPVFQTQIISSVEPHKI-------GVANSLFFNAMDAGMAIGAFIMGMMVESVGY 359
Cdd:COG2211 323 LVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
26-376 |
1.47e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 65.29 E-value: 1.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 26 VLLTLLPIyIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRV 105
Cdd:cd17504 14 MLSPALPT-IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 106 LHGITFGVITTVKGTISARLiPASRRGEGISF----FSLAMGLAMVVGPWIgLNMARWNAftaAFWLCSAVAALGIVLSl 181
Cdd:cd17504 93 LQGIGGAVFPLAFALVREEF-PPERVPVAQGIlsatFGIGAGIGLPLGGWI-VQHLGWRW---IFWTAAPVAVLLAALV- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 182 ivtvpPVIRHADGSKPNLGFAAMfdraalPFALVTFFMTFSYAGVSAFLALyARELDLMAAASN---FLLCYAIFLMICR 258
Cdd:cd17504 167 -----PLIDLRLLRRRNVLLANI------TALLAGFGMFMVFQLLPQLLQL-PTPTGFGLGITEaglLLLPGALVMLIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 259 TFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQII-SSVEPHKIGVANSLFFN 337
Cdd:cd17504 235 PLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVvESVPPDRTGIATGMNTV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446582902 338 AMDAGMAIGAFIMGMMVESV-------------GYRMIYVAGAVLVVLAGAL 376
Cdd:cd17504 315 LRTIGSAIGPAIAGAILTTYtvsitsggvptegAYVLAFLIGAALALAALLL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-146 |
2.82e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 64.22 E-value: 2.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 1 MKEKLWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLS 80
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446582902 81 SLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAM 146
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
11-376 |
7.94e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 62.95 E-value: 7.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAF-LVITA 89
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLsALAKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARW--NAFTAAFW 167
Cdd:cd17370 81 LLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLlgGNYRTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 168 LCSAVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVsAFLALYARELDLmaAASNFL 247
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSF-AFLILRAQELGL--SAALIP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 248 LCYAIFLMICRTFT---GNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVE 324
Cdd:cd17370 238 LLYALFNLVYALAAypaGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446582902 325 PHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGAL 376
Cdd:cd17370 318 AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-256 |
8.00e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.52 E-value: 8.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLC 169
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 170 SAVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASNFLLC 249
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
....*..
gi 446582902 250 YAIFLMI 256
Cdd:COG0477 255 ALLLLAA 261
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
35-376 |
8.14e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.97 E-value: 8.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 35 IADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVI 114
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 115 TTVKGTISARLIPAsRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAVAALGIVLSLIVTVPPVIRHADG 194
Cdd:COG2807 124 NVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 195 SKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDL-MAAASNFLLCYAIFLMICRTFTGNICDK-KGPKY 272
Cdd:COG2807 203 PAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLsAATAGLLLSLFQLAGIPGSLLVPLLADRlGDRRP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 273 VVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGM 352
Cdd:COG2807 283 LLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGA 362
|
330 340
....*....|....*....|....*
gi 446582902 353 MVESVG-YRMIYVAGAVLVVLAGAL 376
Cdd:COG2807 363 LHDATGsWTAALLLLAALAVLMLVA 387
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-183 |
1.07e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.59 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 7 TKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLV 86
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 87 ITALYPVC-HSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWI-GLNMARWNAFTA 164
Cdd:COG2223 284 GLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLfGALLDATGSYTA 363
|
170
....*....|....*....
gi 446582902 165 AFWLCSAVAALGIVLSLIV 183
Cdd:COG2223 364 AFLVFAVLALVALVLTLLL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
8-181 |
4.22e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.69 E-value: 4.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHasaDKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:cd17489 194 KKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 TALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFW 167
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
170
....*....|....
gi 446582902 168 LCSAVAALGIVLSL 181
Cdd:cd17489 351 LAAVVVLLALVLYI 364
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
47-183 |
4.90e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 57.27 E-value: 4.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 47 GLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLI 126
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446582902 127 PASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAVAALGIVLSLIV 183
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFL 137
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
207-376 |
5.34e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 5.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 207 RAALPFALVTFFMTFSYAGVSAFLALYARELDL-MAAASNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGL 285
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGAsPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 286 VALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVA 365
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|.
gi 446582902 366 GAVLVVLAGAL 376
Cdd:COG2814 170 NAVLALLALLL 180
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
16-372 |
6.37e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.33 E-value: 6.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 16 VSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCH 95
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 96 SIESLLFIRVLHGITFGVITTVKGTISARLIPaSRRGEGISFFSLAMGLAMVVGPWI-GLNMARWNAFTAAFWLCSAVAA 174
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIaTSLLTSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 175 LGIVLSLIVTVPPVIRHA-----DGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAA--ASNFL 247
Cdd:cd17333 162 LLAILILLTLFPELPSARnpqqsVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDglAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 248 LCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVePHK 327
Cdd:cd17333 242 SGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL-PYA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446582902 328 IGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVL 372
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-183 |
9.84e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.83 E-value: 9.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 TALYPVC--HSIESLLFIRVLHGITFGVITTVKGTISARLIPAS-----RRGEGI--SFFSLAMGLAMVVGPWIGLNMAR 158
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLyfGIFTFAIKLGQALAGALAGLLLA 387
|
170 180
....*....|....*....|....*
gi 446582902 159 WNAFTAAFwLCSAVAALGIVLSLIV 183
Cdd:COG2211 388 LFGYVAGA-AQSPSALTGIRLLFFL 411
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
1-179 |
1.12e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 1 MKEKLWTKDFWAITIVSFIIFFVFYVLLtlLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLS 80
Cdd:cd17370 193 TSLKKLPKAFWLYLLAVALFALGNFSFA--FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 81 SLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWN 160
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
170
....*....|....*....
gi 446582902 161 AFTAAFWLCSAVAALGIVL 179
Cdd:cd17370 351 SPSAAFLFSAVLALIALLL 369
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
18-379 |
1.35e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 56.05 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 18 FIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI--TALYPVCH 95
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLffLSLFFVAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 96 SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGI--SFFSLAMGLAMV-VGPWIGlNMARWNAFTAAFWLCSAV 172
Cdd:cd17335 86 IFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKqrLWGSIGFGIAALlVGILID-RSSTYKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 173 AALGIVLSLIVTVPPVIRHADGSKPNLGfAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELdlmaAASNFLLCYAI 252
Cdd:cd17335 165 MLLALLLALKFPFRPKHPEPNENTGGLL-ALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL----GGSKTLIGLLW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 253 FLM-----ICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTnGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHK 327
Cdd:cd17335 240 TVGvvseiPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFL-ENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPG 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446582902 328 IGVANSLFFNAMD--AGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGALYAV 379
Cdd:cd17335 319 LRATAQGLLQGLYfgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
7-183 |
1.74e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.66 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 7 TKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLV 86
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 87 ITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWI-GLNMARWNAFTAA 165
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLSGA 355
|
170
....*....|....*...
gi 446582902 166 FWLCSAVAALGIVLSLIV 183
Cdd:cd17473 356 FLILGVLALVLAIVLLLL 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
10-376 |
4.26e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.58 E-value: 4.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIF-----FVFYVLLTLLPIyiADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAF 84
Cdd:cd17355 1 GWVVLAVTFLILilswgIRYYFGVFIIPI--IAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 85 LVITALYPVCHSIESLLF-IRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFT 163
Cdd:cd17355 79 AAGLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 164 AAFWLCSAVAALGIVLS--LIVTVPPVIRHADGSKPNLGFAAMFDRAAL---PFALVT---FFMTFSYAGVSAFLALYAR 235
Cdd:cd17355 159 TALLVLALLALLVLVPVllLLRRRPADLALRAYDDASPASPGSTLKEALrsaSFWLLAlafFLCGFAVVGLIVHLVPYLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 236 ELDLMAAASNFLLCY-AIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGY-TNGSIMMIISGGLIGIGYGSVTP 313
Cdd:cd17355 239 DRGISPAAAAVALALiGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLlPFPPLALLLFAALFGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446582902 314 VFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVG-YRMIYVAGAVLVVLAGAL 376
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALL 382
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
35-153 |
4.58e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 54.69 E-value: 4.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 35 IADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVI 114
Cdd:TIGR00711 28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPL 107
|
90 100 110
....*....|....*....|....*....|....*....
gi 446582902 115 TTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIG 153
Cdd:TIGR00711 108 IPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLG 146
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
17-373 |
6.57e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 54.19 E-value: 6.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 17 SFIIFFVFYVLLTLLPIYIADRLHASADK----AGLLVTC-FLAAAIViRPFAGQWVGKYSNKKILVLSSLAFLVITALY 91
Cdd:cd17391 5 NFFTGIGFSLIAPFLPLYIEQLGVTSGGLvelwSGLAFSStFLVSAIF-SPIWGRLADRYGRKPMLLRASLGMAIVIGLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 92 PVCHSIESLLFIRVLHGITFGVITTVKGTISARlIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSA 171
Cdd:cd17391 84 AFVTNVWQLLILRLLQGVFSGYVPNATALIASQ-TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 172 VAALGIVLSLIVTVP---PVIRHADGSKPNLgFAAMFDRAALPFALVTFFMT-FSYAGVSAFLALYAREldLMAAASNFL 247
Cdd:cd17391 163 LLFLAFLLTLFFVKEdfkPVEKKKMVSTKEV-WNSVPNPSLLISLFVTTFIIqLANQSIEPILTLYIRQ--LMGDASNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 248 LCYAIFL-------MICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQII 320
Cdd:cd17391 240 FISGLVFsatgvssLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446582902 321 SSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLA 373
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLN 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-181 |
9.11e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.58 E-value: 9.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 -TALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWI-GLNMARWNAFTAA 165
Cdd:cd06174 283 gLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLaGFLLAATFGLTGA 362
|
170
....*....|....*.
gi 446582902 166 FWLCSAVAALGIVLSL 181
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
8-182 |
1.81e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 52.61 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFV-FYVLLTLLPIyIADRLHASADKAGLLVTCFLAAAIVIRPFAG-QWVGKYSNKKILVLSSLAFL 85
Cdd:cd17490 194 KKLLFFSLLAILQQMItFSTTFGFTPL-IAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 86 VITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAA 165
Cdd:cd17490 273 AYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352
|
170
....*....|....*..
gi 446582902 166 FWLCSAVAALGIVLSLI 182
Cdd:cd17490 353 FFVIGVIALLAAILSLA 369
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
15-255 |
1.91e-07 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 52.61 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 15 IVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVC 94
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSTHIRS-LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 95 HSIESLLFIRVLHGITFGVITTVKGTISaRLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARW-NAFtaaFWLCSAVA 173
Cdd:cd17390 82 TSLALLFLSRIPLGIFKHTQSLCKAYLS-DLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETdGGF---YYVALLCS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 174 ALGIVLSLIVTV-PPVIRHADGSKPNLGFAAMFDRAALPFALVTFFM--------TFSYAGVSAFLA---------LYAR 235
Cdd:cd17390 158 AIFILNAGLVWFlLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEERFDlspktigyLISYSGVLGALSgflvgrilkLYKN 237
|
250 260
....*....|....*....|
gi 446582902 236 ELDLMAAASNFLLCYAIFLM 255
Cdd:cd17390 238 NEYLLLLHSFILLALSLLGL 257
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
5-183 |
2.43e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.18 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 5 LWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAF 84
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 85 LVITALYPVCH---SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVG------------ 149
Cdd:cd17321 245 AVGLLLLALLGadsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvallgalltagl 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446582902 150 -----------PWIGLNMARWNAFTAAFWLCSAVAALGIVLSLIV 183
Cdd:cd17321 325 sanlgdsgvaaLLSAAAAAFAAGFHLAFLVAAALALLAALLALLL 369
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
46-265 |
2.49e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 52.30 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 46 AGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARL 125
Cdd:cd17371 36 AGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 126 IPASRRGEGI----SFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAVAALGIVLSLIVTVPPVIRHADGSKPNLGF 201
Cdd:cd17371 116 VPARHRGKALgyvqSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFAD 195
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446582902 202 ----AAMFDRAALPFALVTFFMT----FSYAGVSAFLALYAR-ELDLMAAASNFLLCYAIFLMICRTFTGNIC 265
Cdd:cd17371 196 rpslRELFSPPLLRTTLLASLLAtgalGGYYGITTWLPSYLTgERGLSFEGSAGYLVVTILGGFLGYLAGGFL 268
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-188 |
3.52e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.80 E-value: 3.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 5 LWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRlHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAF 84
Cdd:COG2807 212 WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 85 LVIT----ALYPVCHSIESLLFIRVLHGITFGVITTVkgtISARLIPASRRGEGISFFSLAMGLAMVVGPWI-GLNMARW 159
Cdd:COG2807 291 GLAGllglLLAPGSLPWLWAVLLGLGQGGLFPLALTL---IGLRARTPAEAAALSGMAQSVGYLLAALGPLLvGALHDAT 367
|
170 180
....*....|....*....|....*....
gi 446582902 160 NAFTAAFWLCSAVAALGIVLSLIVTVPPV 188
Cdd:COG2807 368 GSWTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-182 |
5.91e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 5.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRVLhgITFG--VITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFW 167
Cdd:cd17329 282 VLAFANTLAVLILAMIV--LTLGemLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
170
....*....|....*
gi 446582902 168 LCSAVAALGIVLSLI 182
Cdd:cd17329 360 ILAALGLIAAALLLG 374
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
10-183 |
6.41e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 51.01 E-value: 6.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADrLHASADKAGLLVTCFLAAAIVIRPFAGqWVG--KYSNKKILVLSSLAFL-V 86
Cdd:cd17352 185 FVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLG-LLAdkPRIGRLYLYIFTLLILgL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 87 ITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNA-FTAA 165
Cdd:cd17352 263 SLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAA 342
|
170
....*....|....*...
gi 446582902 166 FWLCSAVAALGIVLSLIV 183
Cdd:cd17352 343 FYFCGACLLLSGVLLFLL 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-183 |
8.34e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.65 E-value: 8.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSN---KKILVLSSLAF 84
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 85 LVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPW-IGLNMARWNAFT 163
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLlIGYLVDATGSYT 338
|
170 180
....*....|....*....|
gi 446582902 164 AAFWLCSAVAALGIVLSLIV 183
Cdd:cd17319 339 AAFLFLAAVALLAALLVLLL 358
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
7-182 |
8.75e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 50.68 E-value: 8.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 7 TKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGK-YSNKKILVLSSLAFL 85
Cdd:cd17331 206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKrFGERSLLKLSVALLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 86 VITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAA 165
Cdd:cd17331 286 IGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSF 365
|
170
....*....|....*..
gi 446582902 166 FWLCSAVAALGIVLSLI 182
Cdd:cd17331 366 GLLGAAINGLLTVYLLL 382
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-376 |
9.23e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.25 E-value: 9.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 26 VLLTLLPIYIAdRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRV 105
Cdd:cd17478 14 FLPALLPLLIA-KLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 106 LHGITFGVITtVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCsAVAALGIVLSLIVTV 185
Cdd:cd17478 93 LAGIGSAAFH-PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL-IIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 186 PPVIRHADGSKPNLGFAAMFDRAALPFALVTFFM---TFSYAGVSAFLALYARELDLMAAASNFLLcyAIFLMICRTFT- 261
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVflrSWVLSSLTTFLPFYLVQRGYSLVFAGLLL--SLFLFAGAIGTl 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 262 --GNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGL--IGIGYGSVTPVFQTQIIssvePHKIGVANSLFFN 337
Cdd:cd17478 249 igGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAgfLLFASFPVTVVLAQELL----PGNVGLASGLMMG 324
|
330 340 350
....*....|....*....|....*....|....*....
gi 446582902 338 AMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGAL 376
Cdd:cd17478 325 LSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
10-184 |
3.00e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.80 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADrLHASADK----AGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFL 85
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQ-LMGDASNlafiSGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 86 VITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAA 165
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAV 361
|
170
....*....|....*....
gi 446582902 166 FWLCSAVAALGIVLSLIVT 184
Cdd:cd17391 362 FVVTALLVLLNAIWSFIFL 380
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
207-382 |
3.16e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.72 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 207 RAALPFALVTFFMTFS-YAGVSAFLALYARELDL-MAAASNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIG 284
Cdd:COG2223 4 WRVLLLATLAFFLAFGvWYLWSVLAPPLAEEFGLsAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 285 LVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYV 364
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170
....*....|....*...
gi 446582902 365 AGAVLVVLAGALYAVQMK 382
Cdd:COG2223 164 ILGILLLVVAVLAWLFLR 181
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
10-183 |
3.65e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 48.33 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKIL-----VLSSLAF 84
Cdd:cd17502 169 ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLivigtILMSVGA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 85 LVITALYPVCHSIESLLFIrVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPwiglnmarwnAFTA 164
Cdd:cd17502 249 GLLTTLTLDTSKWLLIGYL-ILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGV----------AITD 317
|
170
....*....|....*....
gi 446582902 165 AFWLCSAVAALGIVLSLIV 183
Cdd:cd17502 318 VFLVALALAALAFLLSLFL 336
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
11-285 |
3.67e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 48.41 E-value: 3.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFYVLLTLLPiYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITAL 90
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIP-AIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 91 YPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRgEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCS 170
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGR-PIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 171 AVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMF---DRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASNFL 247
Cdd:cd17393 160 AVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFllpNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAAL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446582902 248 --LCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGL 285
Cdd:cd17393 240 gyAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGL 279
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
11-181 |
4.33e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.34 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFYVLLTLLPIYIADR----LHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLV 86
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 87 ITALYPVCH-SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWI-GLNMARWN---- 160
Cdd:cd17504 260 GLLLLALLHsSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIaGAILTTYTvsit 339
|
170 180
....*....|....*....|....*....
gi 446582902 161 --------AFTAAFWLCSAVAALGIVLSL 181
Cdd:cd17504 340 sggvptegAYVLAFLIGAALALAALLLSL 368
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-181 |
7.38e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.60 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 5 LWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAF 84
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 85 LVITALYPVCHSIES--LLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISF-FSLAMGLAMVVGPWIGLNMARWNA 161
Cdd:cd17316 254 GILALPLFYLLSGSPtlLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 446582902 162 FTAAFWLCSAVAALGIVLSL 181
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
6-391 |
7.67e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 47.61 E-value: 7.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 6 WTKDFWAITIVSFIIFFVFYVLLTLLPIYIaDRLHASADKA-----GLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLS 80
Cdd:PRK09874 12 WKRNLTVAWLGCFLTGAAFSLVMPFLPLYV-EQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 81 SLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARlIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWN 160
Cdd:PRK09874 91 ALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQ-VPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 161 AFTAAFWLCSAVAALGIVLSLIV---TVPPVIRHADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYAREL 237
Cdd:PRK09874 170 GLRPVFFITASVLFLCFLVTLFCireNFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVREL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 238 DLMAAASNFLLCY-----AIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVT 312
Cdd:PRK09874 250 AGNVSNIAFISGMiasvpGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALL 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446582902 313 PVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVlVVLAGALYAVQMKKRGVMPLVS 391
Cdd:PRK09874 330 PAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAG-VVLFNAVYSWNSLRRRRIPQVS 407
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
29-373 |
9.55e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 47.17 E-value: 9.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 29 TLLPIyIADRLHaSADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHG 108
Cdd:cd17502 17 TALPT-IVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 109 ITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLcsavaalgivlslivtvppv 188
Cdd:cd17502 95 IGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI-------------------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 189 irhadgskpNL---GFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAA--ASNFLLCYAIFLMICRTFTGN 263
Cdd:cd17502 155 ---------NLpigGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSAtkSGVRLLPLIIGLVIGSIISGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 264 ICDKKG-PKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIIS---SVEPHKIGVANSLFFNAM 339
Cdd:cd17502 226 LISKTGrYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAvqnAVPPADVGVATATNTFFR 305
|
330 340 350
....*....|....*....|....*....|....
gi 446582902 340 DAGMAIGafimgmmvesVGYRMIYVAGAVLVVLA 373
Cdd:cd17502 306 SLGGTLG----------VAITDVFLVALALAALA 329
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-380 |
1.02e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 46 AGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARL 125
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 126 IPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNaFTAAFWLCSAVAALGIVLSLIVTVPPVIRHADGSKPNLGFAAMF 205
Cdd:cd17473 117 FEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 206 DRAALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASNFLLCYAIFL--MICRTFTGNICDKKGPKYVVYPCLLAFTI 283
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLagAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 284 GLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVG--YRM 361
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGglSGA 355
|
330
....*....|....*....
gi 446582902 362 IYVAGAVLVVLAGALYAVQ 380
Cdd:cd17473 356 FLILGVLALVLAIVLLLLR 374
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
13-372 |
1.05e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.21 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCF-LAAAIVIRPFaGQWVGKYSNKKILVLSSLAFLVITALY 91
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYgLTQAIFQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 92 PVCHSIESLLFIRVLHGItfGVITTVKGTISARLIPASRRGEGISF----FSLAMGLAMVVGPWIGlnmARWNaFTAAFW 167
Cdd:cd17472 80 AYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALigasIGIAFAISMVLGPLLA---AHLG-VSGLFL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 168 LCSAVAALGIVLSLIVT--VPPVIRHADGSKPNLGfAAMFDRAALPFALVTFFMTFSYagVSAFLALYARELDLMAAASN 245
Cdd:cd17472 154 ITAILSLVSLLILLFFVpdPPKIVQISEKEKKKLK-KLLKNKRLLRLDFSIFILHFVL--MAFFYILPLLLTQLGGGKGQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 246 FLLCY------AIFLMIcrtFTGNICDKKG-PKYVVYPCLLAFTIGLVALGYTNGS-IMMIISGGLIGIGYGSVTPVFQT 317
Cdd:cd17472 231 LWKVYlpailiGFILMV---PFVIYAEKKGkMKQVFVSSILLIAVGFLLLLFAATSlWLLIIGLIIFFIGFNLLEALLPS 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446582902 318 QIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVL 372
Cdd:cd17472 308 LVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
7-183 |
1.33e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.88 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 7 TKDFWAITIVSFIIFFVFYVLLTLLPIYIADRlHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLV 86
Cdd:cd17355 209 SASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRAL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 87 ITALYPVCH-SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNA-FTA 164
Cdd:cd17355 288 GLALLLLLPfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTA 367
|
170
....*....|....*....
gi 446582902 165 AFWLCSAVAALGIVLSLIV 183
Cdd:cd17355 368 AWALAVALGLIAALLVLPI 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
7-180 |
2.58e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 7 TKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLV 86
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 87 ITALYPVCH---SIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGpwIGLNMARWNAFT 163
Cdd:cd17503 257 GTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG--TALLATLLTNRT 334
|
170
....*....|....*..
gi 446582902 164 AAFWLCSAVAALGIVLS 180
Cdd:cd17503 335 QFHHSRLSELLAQQVQK 351
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
35-196 |
4.32e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.30 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 35 IADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVI 114
Cdd:cd17328 25 IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 115 TTVKGTISARLIPASRRGEGISFFSLAM----GLAMVVGPWIGLNMARWNaftAAFWLCSAVAALGIVLSLIVTVPPVIR 190
Cdd:cd17328 105 SPIAPTIIADLFPKEKRTRALGVFYFAIplgsGLGYVVGGLVAQATGGWR---WAFRVTGVLGVLLAILLLLFVREPPRG 181
|
....*.
gi 446582902 191 HADGSK 196
Cdd:cd17328 182 AAEGGV 187
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
35-377 |
5.41e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 5.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 35 IADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVI 114
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 115 TTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWLCSAVAALGIVLSLIV---TVPPVIRH 191
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFlpeTLPEEKRK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 192 ADGSKPNLGFAAMF-DRAALPFALVTFFMT---FSYAGVSAFLALYARELDLMAAASNFLLCyAIFLMICRTFTGNICDK 267
Cdd:cd17320 185 PLLSSLLRAYKRVLkNRRFLGYALALGLSFaglFAYLAAAPFIYIEQLGLSPAQFGLLFALN-AIALILGSLLNGRLVRR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 268 KGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISS----VEPHKIGVANSLFFNAMDAGM 343
Cdd:cd17320 264 FGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSlalePFPHVAGTASALLGFLQFLIG 343
|
330 340 350
....*....|....*....|....*....|....
gi 446582902 344 AIGAFIMGMMVEsVGYRMIYVAGAVLVVLAGALY 377
Cdd:cd17320 344 ALAGALVGLLPN-GTALPMGLLILVLGLLALLLL 376
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-379 |
8.23e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.10 E-value: 8.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFY---VLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:cd17319 2 WRIIPLLFLAYVINYldrVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 TALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFW 167
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 168 LCsavAALGIVLSLIVtvppvirhadgskpnlgfaAMFDRAALPFALVTFFMTFSYAGVSAFLALY---ARELDLMAA-- 242
Cdd:cd17319 162 IE---GLLGLLLAVLW-------------------WFYLRQVWGLALGYFGINYALYGLLTWLPTYlkqARGFSLKQVgl 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 243 -ASNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAfTIGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIIS 321
Cdd:cd17319 220 lAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLA-AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPAD 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446582902 322 SVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVG-YRMIYVAGAVLVVLAGALYAV 379
Cdd:cd17319 299 LLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
13-373 |
1.06e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.13 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 13 ITIVSFIIF---FVFYVLLTLLPiYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:cd17331 2 LLIVHLNIVlyaTCYWLQQPVLP-YLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIRV----LHGItfgvitTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAA 165
Cdd:cd17331 81 LLAFASSVPMLFLSRLpsvfMHAM------QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 166 FWLCSAVAALGIVLSLI----VTVPPVIRHADGSK-----PNLGFAAMFDR--AALPFALVTFFMTFSYAGVSAFLALYA 234
Cdd:cd17331 155 ALVAAVGSLLSIVLVILlipsNTKSKREKEAKESAsppsvFNLKEILRLLRlpGVAFLLLVKLLSGLPIGMFQSMFSLVA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 235 RE-LDLMAAASNFLLCYA-IFLMICRTFTGNICDKK-GPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLIGIGYGSV 311
Cdd:cd17331 235 MDfFGLTPEENGYLMSYAgVLGMVVQGLLVGPLTKRfGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446582902 312 TPVFQTQIISSVEPHK----IGVANSLFFnamdAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLA 373
Cdd:cd17331 315 YTVITSLLTKAVPPEDtgtaLGLSHALFS----LVRTVSPTIGGALLQAYGFPSFGLLGAAINGLL 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
212-379 |
1.20e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 212 FALVTFFMTFSYAGVSAFLALY-ARELDLMAAASNFLL-CYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALG 289
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLtLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 290 YTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVL 369
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|
gi 446582902 370 VVLAGALYAV 379
Cdd:pfam07690 161 SLLAAVLLLL 170
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
5-182 |
1.35e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.72 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 5 LWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIR-PFAGQWVGKYSNKKILVLSSLA 83
Cdd:cd17330 171 FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 84 FLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFT 163
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
170
....*....|....*....
gi 446582902 164 AAFWLCSAVAALGIVLSLI 182
Cdd:cd17330 331 VPFLLAAGLLLIALFLLSL 349
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-376 |
2.11e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVtcfLAAAIVIRPFA----GQWVGKYSNKKILVLSSLAFL 85
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLL---FAAGFLGRPIGallfGYLGDRIGRKKALILTLLLFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 86 VITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAA 165
Cdd:cd17316 78 LATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 166 FWLCSAVAALGIVLSLIVTvppvirhadgskpnlgfaamfdRAALPFALVTFFMTFSYAGVSAFLALYARELDLM--AAA 243
Cdd:cd17316 158 WRILFLIGALPALLALLLR----------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLspATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 244 SNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGY--TNGSIMMIISGGLIGIGYGSVTPVFQTQIIS 321
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446582902 322 SVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGAL 376
Cdd:cd17316 296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
207-391 |
3.04e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.49 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 207 RAALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASNFLL-CYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGL 285
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVsAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 286 VALGYTNGSIMMIISGGLIGIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVA 365
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180
....*....|....*....|....*.
gi 446582902 366 GAVLVVLAGALYAVQMKKRGVMPLVS 391
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALL 199
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
47-183 |
4.65e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.26 E-value: 4.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 47 GLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCH---SIESLLFIRVLHGITFGVITTVKGTISA 123
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446582902 124 RLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTA---AFWLCSAVAALGIVLSLIV 183
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGwriPLGLQLVPALLLIIGLLFL 191
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
11-376 |
8.23e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.24 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 11 WAITIVSFIIFFVFY---VLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:cd17314 2 WFVLYVSFLLSAMSTgfiLSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 88 TALYPVCHSIESLLFI-RVLHGITFGVITTVKGTISARLIPaSRRGEGISFFSLAMGLAMVVGpwiglnMARWNAFTAAF 166
Cdd:cd17314 82 YTYLSYVFNSFPLSYAcFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLG------SPLLRILWVFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 167 WLCSAVAALGIVLSLIVTVPPVIR-----------HADGSKPNLGFAAMFDRAALPFALVTFFMTFSYAGVSAFLALYAR 235
Cdd:cd17314 155 GLALVYTILGILAAIVLSVVSLLGfkeppdnqarlHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 236 ELDLMAAA--SNFLLCYAIFLMICRTFTGNICDKKGPKYVVYPCLLAF---TIGLVALGYTNGSIMMIISGGLIGIGYGS 310
Cdd:cd17314 235 SLQLDAPSfvTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTIlglGLCAFLFLLKMTPVGLVLTGSLLGFSYGG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446582902 311 VTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESV-GYRMIYVAGAVLVVLAGAL 376
Cdd:cd17314 315 LFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTpSYISAVYIYAVIVFLASAI 381
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
14-183 |
9.03e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 14 TIVSFIIFFVFYVLLTLLPIYI---ADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITAL 90
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIvpmAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 91 YPVC--HSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLNMARWNAFTAAFWL 168
Cdd:cd17380 81 TPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170
....*....|....*
gi 446582902 169 csaVAALGIVLSLIV 183
Cdd:cd17380 161 ---FGLLGLLWALVW 172
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
10-181 |
1.10e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 10 FWAITIVSFIIFFVFYVLLTLLPIYIADRLhASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITA 89
Cdd:cd17478 197 LLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 90 LYPVCHSIESLLFIrVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGPWIGLnMARWNAFTAAFWLC 169
Cdd:cd17478 276 LFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGA-LADAFGLESVLLIL 353
|
170
....*....|..
gi 446582902 170 SAVAALGIVLSL 181
Cdd:cd17478 354 ALLPLLGALLAF 365
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
13-87 |
1.54e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 40.42 E-value: 1.54e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446582902 13 ITIVSFIIFFV-FYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:cd17366 197 ICIGLVLVFNVtNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVL 272
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
208-384 |
1.96e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 208 AALPFALVTFFMTFSYAGVSAFLALYARELDLMAAASNFL-----LCYAIFLMicrtFTGNICDKKGPKYVVYPCLLAFT 282
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLttlplLAFGLFAP----LAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 283 IGLVALGYTNGSIMMIISGGLIGIGYGSVTPVFqTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMI 362
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL-PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180
....*....|....*....|..
gi 446582902 363 YVAGAVLVVLAGALYAVQMKKR 384
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRR 195
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
42-187 |
3.14e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.34 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 42 SADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVITALYPVCH--SIESLLFIRVLHGITFGVITTVKG 119
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAggGIALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 120 TISARLIPASRRGE--GISFFSLAMGlAMVVGPWIGLNMARWNAFTAAFWLCSAVaalGIVLSLIVTVPP 187
Cdd:TIGR00894 154 KIIVKWAPPKERSRllGMSTSGFQLG-TFIFLPISGWLCESWGGWPMIFYVFGIV---GCAWSLLWFVFP 219
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
8-109 |
3.52e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.21 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 8 KDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSSLAFLVI 87
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100
....*....|....*....|...
gi 446582902 88 TALYP-VCHSIESLLFIRVLHGI 109
Cdd:TIGR00886 81 CLWAGlAVQSYSVLLLIRLFIGI 103
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
2-183 |
3.84e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.34 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 2 KEKLWTKDFWAITIVSFIIFFVFYVLLTLLPIYIADRLHASADKAGLLVTCFLAAAIVIRPFAGQWVGKYSNKKILVLSS 81
Cdd:TIGR00894 255 KAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTA 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 82 LAFL------------VITALYPVCHSIESLLFIrVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVG 149
Cdd:TIGR00894 335 ARKIfngigglgpgifAYALPYLSAAFYLTIIIL-TLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIAS 413
|
170 180 190
....*....|....*....|....*....|....*.
gi 446582902 150 PWIGLNMAR--WNAFTAAFWLCSAVAALGIVLSLIV 183
Cdd:TIGR00894 414 TLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLIF 449
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
226-376 |
4.19e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 226 VSAFLALYARELDLMAAASNFLL-CYAIFLMICRTFTGNICDKKGPKYVVYPCLLAFTIGLVALGYTNGSIMMIISGGLI 304
Cdd:cd17324 18 IQGLLPDIARDFGVSVAQAGLLVsAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALA 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446582902 305 GIGYGSVTPVFQTQIISSVEPHKIGVANSLFFNAMDAGMAIGAFIMGMMVESVGYRMIYVAGAVLVVLAGAL 376
Cdd:cd17324 98 GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
71-230 |
7.86e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 37.97 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 71 YSNKKILVLSSLAFLVITALYPVCHSIESLLFIRVLHGITFGVITTVKGTISARLIPASRRGEGISFFSLAMGLAMVVGP 150
Cdd:PRK11102 53 FGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAP 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582902 151 WIGLNMARWNAFTAAFWLCSAVAALGIVLSLIV---TVPPVIRHADGSKPNLG-FAAMF-DRAALPFALVTffmTFSYAG 225
Cdd:PRK11102 133 IIGGWLLVWFSWHAIFWVLALAAILAAALVFFFipeTLPKERRQPFHLRTTIRnFASLFrHKRVLGYMLAS---GFSFAG 209
|
....*
gi 446582902 226 VSAFL 230
Cdd:PRK11102 210 MFSFL 214
|
|
| |
