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Conserved domains on  [gi|446586776|ref|WP_000664122|]
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MULTISPECIES: winged helix-turn-helix domain-containing protein [Acinetobacter]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10005147)

winged helix-turn-helix domain-containing protein binds DNA and may function as a transcriptional regulator; similar to the N-terminal domain of molybdate-dependent transcriptional regulator ModE

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ModE COG2005
DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];
5-116 3.52e-37

DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];


:

Pssm-ID: 441608 [Multi-domain]  Cd Length: 118  Bit Score: 121.85  E-value: 3.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   5 NLKLQIRILLEQNIAFGPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTAL 84
Cdd:COG2005    4 KLRLKLWLELDGGVFLGPGRIELLEAIDETGSISAAAKAMGMSYKRAWDLIDAMNNLLGEPLVERQTGGKGGGGARLTPE 83
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446586776  85 GQKVLQHYRQMEINARQALEHDYQIMSSYLKG 116
Cdd:COG2005   84 GRRLLALYRRLEAEAQRALAALFEELFALLRS 115
 
Name Accession Description Interval E-value
ModE COG2005
DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];
5-116 3.52e-37

DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];


Pssm-ID: 441608 [Multi-domain]  Cd Length: 118  Bit Score: 121.85  E-value: 3.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   5 NLKLQIRILLEQNIAFGPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTAL 84
Cdd:COG2005    4 KLRLKLWLELDGGVFLGPGRIELLEAIDETGSISAAAKAMGMSYKRAWDLIDAMNNLLGEPLVERQTGGKGGGGARLTPE 83
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446586776  85 GQKVLQHYRQMEINARQALEHDYQIMSSYLKG 116
Cdd:COG2005   84 GRRLLALYRRLEAEAQRALAALFEELFALLRS 115
ModE_repress TIGR00637
ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the ...
21-105 7.15e-17

ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the molybdate transport operon in E. coli. It consists of the domain represented by this model and two tandem copies of mop-like domain, where Mop proteins are a family of 68-residue molybdenum-pterin binding proteins of Clostridium pasteurianum. This model also represents the full length of a pair of archaeal proteins that lack Mop-like domains. PSI-BLAST analysis shows similarity to helix-turn-helix regulatory proteins. [Regulatory functions, Other]


Pssm-ID: 273188 [Multi-domain]  Cd Length: 99  Bit Score: 69.78  E-value: 7.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   21 GPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTALGQKVLQHYRQMEinar 100
Cdd:TIGR00637   3 DPRRVALLKAIARMGSISQAAKDAGISYKSAWDYIRAMNNLSGEPLVERATGGKGGGGAVLTEYGQRLIQLYDLLE---- 78

                  ....*
gi 446586776  101 QALEH 105
Cdd:TIGR00637  79 RILEK 83
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
6-114 7.47e-11

DNA-binding transcriptional regulator ModE; Provisional


Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 56.97  E-value: 7.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   6 LKLQIRILLEqniafgPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTALG 85
Cdd:PRK10676   9 LKLQQRLFAD------PRRISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYG 82
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446586776  86 QKVLQHY---RQMEINARQALEHDYQIMSSYL 114
Cdd:PRK10676  83 ERLIQLYdllAQIQQKAFDVLDDDALPLDSLL 114
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
27-68 8.14e-04

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 35.05  E-value: 8.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446586776   27 LLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVE 68
Cdd:pfam00126   6 LFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFE 47
 
Name Accession Description Interval E-value
ModE COG2005
DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];
5-116 3.52e-37

DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];


Pssm-ID: 441608 [Multi-domain]  Cd Length: 118  Bit Score: 121.85  E-value: 3.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   5 NLKLQIRILLEQNIAFGPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTAL 84
Cdd:COG2005    4 KLRLKLWLELDGGVFLGPGRIELLEAIDETGSISAAAKAMGMSYKRAWDLIDAMNNLLGEPLVERQTGGKGGGGARLTPE 83
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446586776  85 GQKVLQHYRQMEINARQALEHDYQIMSSYLKG 116
Cdd:COG2005   84 GRRLLALYRRLEAEAQRALAALFEELFALLRS 115
ModE_repress TIGR00637
ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the ...
21-105 7.15e-17

ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the molybdate transport operon in E. coli. It consists of the domain represented by this model and two tandem copies of mop-like domain, where Mop proteins are a family of 68-residue molybdenum-pterin binding proteins of Clostridium pasteurianum. This model also represents the full length of a pair of archaeal proteins that lack Mop-like domains. PSI-BLAST analysis shows similarity to helix-turn-helix regulatory proteins. [Regulatory functions, Other]


Pssm-ID: 273188 [Multi-domain]  Cd Length: 99  Bit Score: 69.78  E-value: 7.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   21 GPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTALGQKVLQHYRQMEinar 100
Cdd:TIGR00637   3 DPRRVALLKAIARMGSISQAAKDAGISYKSAWDYIRAMNNLSGEPLVERATGGKGGGGAVLTEYGQRLIQLYDLLE---- 78

                  ....*
gi 446586776  101 QALEH 105
Cdd:TIGR00637  79 RILEK 83
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
6-114 7.47e-11

DNA-binding transcriptional regulator ModE; Provisional


Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 56.97  E-value: 7.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446586776   6 LKLQIRILLEqniafgPGKADLLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVETQTGGTHGGGAAVTALG 85
Cdd:PRK10676   9 LKLQQRLFAD------PRRISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTRYG 82
                         90       100       110
                 ....*....|....*....|....*....|..
gi 446586776  86 QKVLQHY---RQMEINARQALEHDYQIMSSYL 114
Cdd:PRK10676  83 ERLIQLYdllAQIQQKAFDVLDDDALPLDSLL 114
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
27-68 8.14e-04

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 35.05  E-value: 8.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446586776   27 LLEAIERTGSISQAAKSMNMSYRRAWQLVDTMNQCFETALVE 68
Cdd:pfam00126   6 LFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFE 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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