|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
11-367 |
1.84e-80 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 251.45 E-value: 1.84e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 11 IAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIKNREKILHHC-LFFNVLSTLC 89
Cdd:cd06180 1 LAGALALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGgLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 90 MGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSI-WNWQGAWIGL 168
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 169 GIISFSLAILVWKWLRE-DSRHTIQQPKSTIQATSHRksyLFWLILAYGFEGFGYIITGTFLVTIVERITLSPFYASCSW 247
Cdd:cd06180 161 ALLSAVLLLLSFLLLRRgPSAPTEASAAESAPGLNRP---LWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 248 IIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEAKRIRPNES 327
Cdd:cd06180 238 SLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446587975 328 NKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd06180 318 PRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAA 357
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
21-367 |
1.42e-69 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 223.02 E-value: 1.42e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 21 MGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIKNREKI---LHHCLFFNVLSTLCMGLTSYIF 97
Cdd:pfam06779 5 MGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLrpaLLAGLLATVLLLLAMAATSSFW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 98 LWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSI-WNWQGAWIGLGIISFSLA 176
Cdd:pfam06779 85 AVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLgLGGSSLWYGAGVLSAVLT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 177 ILVWKWLREDsRHTIQQPKSTIQATSHRKSYLFWLILAYGFEGFGYIITGTFLVTIVERITLSPFYASCSWIIVGIAVIP 256
Cdd:pfam06779 165 LAVFPLLPRR-APRHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAAAL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 257 SSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEAKRIRPNESNKIIGYTTG 336
Cdd:pfam06779 244 GVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRRLLGLMTA 323
|
330 340 350
....*....|....*....|....*....|.
gi 446587975 337 VYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:pfam06779 324 SFGIGQILGPLLASLLTAATGGLTPALLLAA 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-342 |
1.93e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.92 E-value: 1.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 8 KMIIAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT-IKNREKILHHCLFFNVLS 86
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAdRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 87 TLCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWI 166
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 167 GLGIISFSLAILVWKWLREDSRHTIQQPKSTIQATSHRKSyLFWLILAYGFEGFGYIITGTFLVTIVERIT-LSPFYASC 245
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPR-LLLLLLLAFLLGFGFFALFTYLPLYLQEVLgLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 246 SWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEA-KRIRP 324
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVaELAPP 327
|
330
....*....|....*...
gi 446587975 325 NESNKIIGYTTGVYGIGQ 342
Cdd:COG2814 328 EARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-346 |
5.07e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 5.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 14 ICSLIAVMGISRFAYTPIIS-FMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMG 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRfGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 92 LTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGLGII 171
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 172 SFSLAILVWKWLREDSRHTIQQPKSTIQATSHRKSYL-----FWLILAYGFEGFGYIITGTFLVTIVERITLSPFYASCS 246
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALlrdpvLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 247 WIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLS---PLLIPNLFGAFLSAFLLGATF-VGITILTTTEAKRI 322
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGlllLSLTLSSLWLLLALLLLGFGFgLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 446587975 323 RPNESNKIIGYTTGVYGIGQIIGP 346
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-367 |
2.85e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 91.47 E-value: 2.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 9 MIIAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLST 87
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRfGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 88 LCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYlFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIG 167
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW-FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 168 LGIISFsLAILVWKWLREDSRHTIQQPKSTIQATSHRKSYLFWLI-LAYGFEGFGYIITGTFLVTIVERITLSPFYASCS 246
Cdd:COG2807 177 WALLAL-LALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLtLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 247 WIIVGIAVIPSSYLWSTVARKYGPTR-ALTSAYMLQIISVLSPLLIPnLFGAFLSAFLLGATFVGITILTTTEAKRI--R 323
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAP-GSLPWLWAVLLGLGQGGLFPLALTLIGLRarT 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446587975 324 PNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:COG2807 335 PAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLA 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
20-367 |
1.93e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 1.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 20 VMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT-IKNREKILHHCLFFNVLSTLCMGLTSYIFL 98
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSdRIERRRLLLVLLLLFILGNLLAALAPSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 99 WFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGLGIISFSLAIL 178
Cdd:cd17324 90 LLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 179 VWKWLREDSRHTIQQPKSTIQATSHRKSYLFWLILAYGFEGFGYIITG-TFLVTIVEritlSPFYASCSWII-----VGI 252
Cdd:cd17324 170 LWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLT----DVPGFSSSAIIgllllFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 253 AVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEAKRIRPNESNKIIG 332
Cdd:cd17324 246 AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS 325
|
330 340 350
....*....|....*....|....*....|....*
gi 446587975 333 YTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAA 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-367 |
3.76e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 85.32 E-value: 3.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 10 IIAGICSLIAVMgiSRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIKN-REKILHHCLFFNVLSTL 88
Cdd:COG2223 8 LLATLAFFLAFG--VWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFgPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 89 CMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGL 168
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 169 GIISFSLAILVWKWLREDSRHTIQQPKSTI----QATSHRKSYLFWLILAYGFeGFGYIITGTFLVTIVERITLSPFYAS 244
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKASLrdqlEALRDPRFWLLSLLYFGTF-GSFIGFSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 245 cswIIVGIAVIPSS---YLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTT--TEA 319
Cdd:COG2223 245 ---LLAALFALLGAlgrPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVfaLVP 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446587975 320 KRIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFA 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-367 |
4.32e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.92 E-value: 4.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 1 MKETKTWKMIIAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHC 79
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRfGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 80 LFFNVLSTLCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIW 159
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 160 NWQGAWIGLGIISFSLAILVwkwlredsrhtiqqpkstiqatshrksyLFWLILAYGFEGFGYIITGTFLVTI-VERITL 238
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLR----------------------------FWLLALAYFLVYFALYGFLTWLPTYlVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 239 SPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSA--YMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTT 316
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446587975 317 TEAKRI-RPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMqSFSLPLLVAA 367
Cdd:COG2271 294 ALAAELfPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLA 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-367 |
1.72e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.24 E-value: 1.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 14 ICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGL 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRfGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 93 TSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSI--WNWQGAWIGLGI 170
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 171 ISFSLAILVWKWLREDSRHTIQQPKSTIQATS-------HRKSYLFWLILAYGFEGFGYIITGTFLVTIVERIT-LSPFY 242
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVlkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGgLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 243 ASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYML-QIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTT-EAK 320
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAlIAE 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446587975 321 RIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-367 |
1.33e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 74.52 E-value: 1.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 14 ICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGL 92
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRvGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 93 TSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIwNWQGAWIGLGIIS 172
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 173 FSLAILVWKWLredsrhtiqqPKSTIQATSHRKSYLFWLILAYGFegFGYIITGTFLVTIVeriTLSPFYASCSWIIVGI 252
Cdd:cd17477 160 LALVPLLLTRR----------AAPEIEEAESISLRRLLRIAPLAL--LGAFVAGFLEGAFY---SLLPLYGLRLGLSVAQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 253 AV--IPSSYLWSTV--------ARKYGPTRALT-SAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEA-K 320
Cdd:cd17477 225 AAllLAAFVLGGLLlqwplgwlADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAgD 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446587975 321 RIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAA 351
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-367 |
5.40e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 5.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 14 ICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGL 92
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRfGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 93 TSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGLGIIS 172
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 173 FSLAILVWKWLREDSRHTIQQPKSTIQATSHRKSYLFW--LILAYGFEGFGYIITGTFLVTI----VERITLSPFYASCS 246
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDrrLLALFLAIFVLAFAFGALEPFLplyaAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 247 WIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTE-AKRIRPN 325
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlADIVPPE 320
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446587975 326 ESNKIIGYTTGVYGIGQIIGPIFTGIIAEQmQSFSLPLLVAA 367
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-FGFATPFLAAA 361
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
84-367 |
8.03e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.06 E-value: 8.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 84 VLSTLCMGLTSYIFLWFPLRFIGgfTSAIVFVLASSIVLdYLFQSNKVMLGGMIYSGVGIGIIFsgsFAPLF---NSIWN 160
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLGGGG--AGTLAAVAFATVAA-WWFERRRGLALGILTAGGGLGSLV---FLPLGaalIEAFG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 161 WQGAWIGLGIISFSLAILVWKWLREDSRHTIQQPKSTIQATSHR-------KSYLFWLI-LAYGFEGFGYIITGTFLVTI 232
Cdd:cd17355 157 WRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGstlkealRSASFWLLaLAFFLCGFAVVGLIVHLVPY 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 233 VERITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLF-GAFLSAFLLGATFVGI 311
Cdd:cd17355 237 LADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPlALLLFAALFGLGWGAT 316
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446587975 312 TILTTTEAKRIRPNES-NKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd17355 317 VPLTAALAARYFGARSyGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAV 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-367 |
1.08e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.56 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 1 MKETKTWKMIIAgICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHC 79
Cdd:COG0738 1 MSKKNYRRALIA-IYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRfGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 80 LFFNVLSTLCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGM--IYSGVGIGIIFSGSFAPLFNS 157
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLhaFFSLGALLGPLLGGLLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 158 IWNWQGAWIGLGIISFSLAILVWKWLREDSRHTIQQPKSTIQATSH--RKSYLFWLILAYGFEGFGYIITGTFLVTIVER 235
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSllKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 236 I-----TLSPFYASCSWIIVGIAVIPSSYLwstvARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVG 310
Cdd:COG0738 240 VlglseATAALGLSLFWGGMTIGRFLGGFL----LKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 311 ITILTTTEAKRIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQM---QSFSLPLLVAA 367
Cdd:COG0738 316 MFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFglrAAFLVPLVCYL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
133-352 |
2.05e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 133 LGGMIYSGVGIGIIFSGSFAPLF------NSIWNWQGAWIGLGIISFSLAILVWKWLREdsRHTIQQPKSTIQATSH--- 203
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKE--RPVPEEEKVSLKESLKall 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 204 RKSYLFWLILAYGFEGFGYIITGTFLVTIVE-RITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQI 282
Cdd:COG2211 226 KNRPFLLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 283 ISVLSPLLIP--NLFGAFLSAFLLGATFVGITILTTT---------EAKRIRPNESnKIIGYTTGVYGIGQIIGPIFTGI 351
Cdd:COG2211 306 LGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAmladvvdydEWKTGRRREG-LYFGIFTFAIKLGQALAGALAGL 384
|
.
gi 446587975 352 I 352
Cdd:COG2211 385 L 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
45-367 |
4.32e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.53 E-value: 4.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 45 LAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLD 123
Cdd:cd17316 37 QTGLLFAAGFLGRPIGALLFGYLGDRiGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 124 YLFQSNKVMLGGMIYSGVGIGIIFSGSFA----PLFNSIWNWQGAWIGLGIISFSLAILvwkwlredsrhtiqqpkstiq 199
Cdd:cd17316 117 FAPSKRRGFALGLLQSGWALGALLAALVAslliPLLSGDWGWRILFLIGALPALLALLL--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 200 atshRKSYLFwLILAYGFEGFGYIITGTFLVTIVERIT-LSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAY 278
Cdd:cd17316 176 ----RRRTLL-LILLWFFISFGYYGLTTFLPTYLQTVLgLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 279 MLQIISV-----LSPLLIPNLFGAFLSAFLLGATFVGITILTTTE--AKRIRpnesNKIIGYTTGVYGIGQIIGPIFTGI 351
Cdd:cd17316 251 ILSGILAlplfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAElfPTEVR----ATGVGLSYNLGRLGGGGAPPLIAL 326
|
330
....*....|....*.
gi 446587975 352 IAEQMQSFSLPLLVAA 367
Cdd:cd17316 327 LLASTGGTGVPALILA 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-367 |
4.81e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 16 SLIAVMGISrfAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT-IKNREKILHHCLFFNVLSTLCMGLTS 94
Cdd:cd17474 8 TLLAVLGVS--IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLAdRFGRKKVLLPGLLLFGIGGLLCGLSD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 95 YIFLWFPLRFIGGFTSAIVFVLASSIVLDyLFQSN---KVMlgGMIYSGVGIGIIFSgsfaPLFNSI---WNWQGAWIGL 168
Cdd:cd17474 86 SFALLLAGRALQGIGAAGLGPLALTLIGD-LFEGGeraKAM--GLYEAALGLGIAVG----PLLGGLlaaISWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 169 GIISFSLAILVWKWLREDSRHTIQQPKSTIQATSHRKSY-LFWLILAYGFegFGYIITGTFLV----TIVERITLSPFYA 243
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGrGLLTFLVSAF--LYFFLYFAFLTylpfLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 244 SCSWIIVGIAVIPSSYLWST-VARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATF-VGITILTTTEAKR 321
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTEL 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446587975 322 IRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMqSFSLPLLVAA 367
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF-GLSAPFLVGA 361
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-313 |
1.72e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.58 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 16 SLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT-IKNREKILHHCLFFNVLSTLCMGLTS 94
Cdd:cd17320 6 LLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSdRFGRRPVLLAGLLLFILASLLCALAS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 95 YIFLWFPLRFIGGFTSAIVFVLASSIVLDyLFQSNKVMlggMIYSGVGIGIIFSGSFAPLFNSI----WNWQGAWIGLGI 170
Cdd:cd17320 86 SIEQLLIARFLQGLGAAAGSVVARAIVRD-LYSGAELA---KIFSLLMMILAIAPALAPLLGGLlllfFGWRAIFVFLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 171 ISFSLAILVWKWLRE--DSRHTIQQPKSTIQA----TSHRKSYLFWLILAYGFEG-FGYIITGTFLVtiVERITLSPFYA 243
Cdd:cd17320 162 LGLLLLLLVLLFLPEtlPEEKRKPLLSSLLRAykrvLKNRRFLGYALALGLSFAGlFAYLAAAPFIY--IEQLGLSPAQF 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 244 SCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITI 313
Cdd:cd17320 240 GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-352 |
2.06e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.20 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 17 LIAVMGISRFAYT---PIISFMEKQAHIEDD---LAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLC 89
Cdd:cd17330 1 LFLVVFLDALGFGivfPVLPFYVREFNKLGAsgyYVGLLQSSYSLGQFLASPLWGRLSDRyGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 90 MGLTSYIFLWFPLRFIGGFTSAiVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGLG 169
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 170 IISFSLAILVWKWLRedsrhtiqqpkstiqatshrksYLFWLILAYGFEGFGYI-ITGTFLVTIVERITLSPFYASCSWI 248
Cdd:cd17330 160 ALALLNLVLVLFFLP----------------------PLRRLLLVYFLIALAFAgLESVFSLFLKDRFGFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 249 IVGIA-VIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGA-TFVGITILTTTEAKRIRPNE 326
Cdd:cd17330 218 LVGIAgILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFgTGIVFPALSALLSKSVPSKE 297
|
330 340
....*....|....*....|....*.
gi 446587975 327 SNKIIGYTTGVYGIGQIIGPIFTGII 352
Cdd:cd17330 298 QGKAQGIIQSLQSLARIIGPLLAGPL 323
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-367 |
3.58e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.83 E-value: 3.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 14 ICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGL 92
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRfGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 93 TSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNkvMLGGMIYSGVGIGIifSGSFAPLF-NSIWNWQG----AWIG 167
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR--RGEGIGYYGLATTL--AMALGPALgLFLYQHLGfavlFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 168 LGIISFSLAILVWKWLREDSRHTIQQPKStiQATSHRKSYLFWLI-LAYGFEGFGYIITGTFLVTIVERITLSpfYASCS 246
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPVAAEEAEAGT--RAFRRLVEKKVLPPaLILFLASIAYGAISTFLPLYAAERGIS--NAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 247 WIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATF-VGITILTTTEAKRIRPN 325
Cdd:cd17489 233 FTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFgLLFPALQALAVDLVPPH 312
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446587975 326 ESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMqSFSLPLLVAA 367
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAA 353
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
37-352 |
5.02e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.05 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 37 KQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT--IKNREKILHHCLFFNVLSTLCMGLTSYIFLW-FPLRFIGGFTSAIV 113
Cdd:cd17335 25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALAdrFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLlLLLVILGAFFSAPV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 114 FVLASSIVLDYLFQSN----KVMLGGMIysGVGIGIIFSGSFAPLFNSIWNWQGAWIGLGIISFSLAILVWKWLREDSRH 189
Cdd:cd17335 105 VPLVDSITLQYLGEERerygKQRLWGSI--GFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 190 TIQQPKSTIQATSHRKSYLFWLILAyGFEGFGYIITGTFLVTIVERITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYG 269
Cdd:cd17335 183 EPNENTGGLLALLRNPRVLAFLLVA-FLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 270 PTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEAKRIRPNE-SNKIIGYTTGVY-GIGQIIGPI 347
Cdd:cd17335 262 HVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGlRATAQGLLQGLYfGLGGGLGSL 341
|
....*
gi 446587975 348 FTGII 352
Cdd:cd17335 342 IGGYL 346
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
23-354 |
9.71e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.30 E-value: 9.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 23 ISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT--IKNREKILHHCLFFNVLSTLCMGLTSYIFLWF 100
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSdrIGKRKLFIIIGLLFTVLASLIMILFPSPWGLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 101 PLRFIGGFTSAiVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAW---IGLGIISFSLAI 177
Cdd:cd17490 90 IARFLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 178 LVWKwlREDSRHTIQQPKSTIQATSHRKSYLFWLILAYGFEGFGYIITGTFLVTIVERITLSPFYASCSWIIVGIAVIPS 257
Cdd:cd17490 169 FIKE--ERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 258 SYLWSTVA-RKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATF-VGITILTTTEAKRIRPNESNKIIGYTT 335
Cdd:cd17490 247 SLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQ 326
|
330
....*....|....*....
gi 446587975 336 GVYGIGQIIGPIFTGIIAE 354
Cdd:cd17490 327 AIYALGMFLGPVLVGIISE 345
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-353 |
1.12e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.05 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 9 MIIAGICSLIAVM-GISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLF-FNVL 85
Cdd:TIGR00895 16 WRAIILSFLIMLMdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRiGRRRVLLWSILlFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 86 STLCMGLTSYIFLWFpLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAW 165
Cdd:TIGR00895 96 TLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 166 IGLGIISFSLAILVWKWLREDSRHTIQQPKSTI-------------------------------------QATSHRKSYL 208
Cdd:TIGR00895 175 YVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVrrivnaiapqmqaeaqsalpeqkstqgtkrsvfkalfQGKTARITVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 209 FWliLAYGFEGFGYIITGTFLVTIVERITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPtRALTSAYMLQ---IISV 285
Cdd:TIGR00895 255 LW--LLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP-RVTALLLLLGavfAVLV 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446587975 286 LSPLLIPNLF---GAFLSAFLLGATFVGITILTTTEAKRIRPNEsnkiIGYTTGVYGIGQIIGPIFTGIIA 353
Cdd:TIGR00895 332 GSTLFSPTLLlllGAIAGFFVNGGQSGLYALMALFYPTAIRATG----VGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-367 |
1.55e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 1.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 46 AGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDY 124
Cdd:cd17365 36 LGPVGSAALFGMAIGALLAGPLADRfGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 125 LFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGLGIISFSLAILVWkwlredsrhtiqqpkSTIqatshr 204
Cdd:cd17365 116 APARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR---------------GTL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 205 ksyLFWliLAYGFEGFGYIITGTFLVTIVERITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIIS 284
Cdd:cd17365 175 ---LLW--VTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVS 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 285 VLSPLLIPN-LFGAFLSAFLLGATFVGITILTTTEAKRIRPNESNKI-IGYTTGVYGIGQIIGPIFTG-IIAEQMQSFSL 361
Cdd:cd17365 250 LALLGVSPAsLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATgVGWALGVGRLGAILGPLLGGlLLAAGLGPESV 329
|
....*.
gi 446587975 362 PLLVAA 367
Cdd:cd17365 330 FLALAI 335
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
9-367 |
2.38e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.11 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 9 MIIAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK--NREKILHHCLFFNVLS 86
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRfgARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 87 TLCMGLTSYIFLWFpLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWI 166
Cdd:cd17319 83 ALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 167 GLGIISFSLAILVWKWLREdsrhtiqqpkstiqatshrksyLFWLILAYgfegFGYIITGTFLVT-----IVERITLSPF 241
Cdd:cd17319 162 IEGLLGLLLAVLWWFYLRQ----------------------VWGLALGY----FGINYALYGLLTwlptyLKQARGFSLK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 242 YASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGI----TILTTT 317
Cdd:cd17319 216 QVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIgaasPVFWSL 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446587975 318 EAKRIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd17319 296 PADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLA 345
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-315 |
5.73e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.00 E-value: 5.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 25 RFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGLTSYIFLWFPLR 103
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRyNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 104 FIGGFTSAIVFVLASSIVLDyLFQSNKVMLGGMIYS-----GVGIGIIFSGSFAplfNSIWNWQGAWIGLGIISFSLAIL 178
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIAD-LFPKEKRTRALGVFYfaiplGSGLGYVVGGLVA---QATGGWRWAFRVTGVLGVLLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 179 VW-------KWLREDSRHTIQQPKSTIQATSHRKSYLFWLILAYGFEGFGYIITG------TFLVTIveRITLSPFYASC 245
Cdd:cd17328 171 LLlfvreppRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGAlafwapTFFLRA--FGVGDLSSADV 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446587975 246 SWI---IVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLS-PLLIPNLFGAFLSAFLLGAT-FVGITILT 315
Cdd:cd17328 249 GLIfgaITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAaPFLFLALVLALSNLLLAWVLlFLGEFLLS 323
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
199-367 |
2.16e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 199 QATSHRKSYLFWLILAYGFEGFGYIITGTFLVTIVERITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAY 278
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 279 MLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEAKRI-RPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMq 357
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLvPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF- 161
|
170
....*....|
gi 446587975 358 SFSLPLLVAA 367
Cdd:COG2814 162 GWRWVFLVNA 171
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
22-355 |
2.38e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 22 GISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGLTSYIFLWF 100
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRlGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 101 PLRFIGGFTSAIVFVLASSIVLDyLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWN-WQGAWIGLGIISFSLAILV 179
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGA-LFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELsWSWAYLIIGLIYLLLAILI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 180 ----WKWLREDSRH-TIQQPKSTIQATSHRKSYLFWLILAYGFEGFGYIITGTFLVTIVER-----ITLSPFYASCSWII 249
Cdd:cd17333 168 lltlFPELPSARNPqQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEkkhvsDGLAGYLLSGFWVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 250 VGIAVIPSSYlwstVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATFVGITILTTTEAKRIRPNESNK 329
Cdd:cd17333 248 ITIGRLLGGP----ISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGK 323
|
330 340
....*....|....*....|....*.
gi 446587975 330 IIGYTTGVYGIGQIIGPIFTGIIAEQ 355
Cdd:cd17333 324 GTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-188 |
2.47e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 6 TWKMIIAGICSLIAVMGISRFaytpIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIKNREKILHHCLFFNVL 85
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTW----LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 86 STLCMGLTSYI---FLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQ 162
Cdd:COG2271 258 AALALLLLALLpspALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|....*.
gi 446587975 163 GAWIGLGIISFSLAILVWKWLREDSR 188
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
218-367 |
3.00e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 218 EGFGYIITGTFLVTIVERI---TLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNL 294
Cdd:cd17330 8 DALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446587975 295 FGAFLSAFLLGATFVGITILTTTEAKRIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAeQMQSFSLPLLVAA 367
Cdd:cd17330 88 WLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS-TPYGYALPFLVAA 159
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-181 |
5.74e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 5.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 5 KTWKMIIAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIG-FITIKNREKILHHCLFFN 83
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGrLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 84 VLSTLCMGLTSYIFLWFPLRFIGGFTSAIvfvlaSSIVLDYLFQSN--KVMLG---GMIYSGVGIGIIFSGSFAPLFNSI 158
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGL-----FNVPLNTLLQLRvpDELRGrvfSVYNALNSGAMPLGALLAGLLADA 359
|
170 180
....*....|....*....|...
gi 446587975 159 WNWQGAWIGLGIISFSLAILVWK 181
Cdd:cd06173 360 LGLSAVFLLAGALLLLAALLLLL 382
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-304 |
7.34e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 9 MIIAGICSLIAVMGISrfAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFIT-IKNREKILHHCLFFNVLST 87
Cdd:COG0477 16 LLALALGTFLEGLDFT--IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGdRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 88 LCMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIG 167
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 168 LGIIsfSLAILVWKWLREDSRHTIQQPkstiqatshrksyLFWLILAYGFEGFGYIITGTFLVTIVERITLSPFYASCSW 247
Cdd:COG0477 174 NAPL--GLLALVLRLRLPESRGLLLAL-------------LALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446587975 248 IIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLL 304
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-367 |
9.28e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 9.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 16 SLIAVMGISrfAYTPIISFMEKQAHIEDD-LAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMGLT 93
Cdd:cd17473 8 STLTVMAGA--AIAPALPAIAQHFVPNSElLVPLLLTLPALFIALFAPLAGWLADRfGRKRLLIAGLLLYGIGGVAGLFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 94 SYIFLWFPLRFIGGFTSAIVFVLASSIVLDYlFQ---SNKVM--LGGMIYSGVGIGIIFSGSFAPLfnsiwNWQGAWIGL 168
Cdd:cd17473 86 DSLYALLASRALLGIGVAGIMTLATALIGDY-FEgeeRAKMLglQSAAMSLGGVVFLLLGGALAEI-----GWRAPFLVY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 169 GIiSFSLAILVWKWLREDSRHTIQQPKstiQATSHRKSYLFWLILAYGFEGFGYIITGTFLVT-----IVERITLSPFYA 243
Cdd:cd17473 160 LL-ALPVLILVLLFLPEPARKSKSAAS---PGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIqlpflLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 244 SCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLFGAFLSAFLLGATF-VGITILTTTEAKRI 322
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFgLLLPTLNSWAMSLV 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446587975 323 RPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFSLPLLVAA 367
Cdd:cd17473 316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILG 360
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
14-295 |
3.09e-04 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 42.57 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 14 ICSLIAVMGISrFAYTP-IISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTLCMG 91
Cdd:pfam03137 6 LSLLGLAQALV-SGYFNsSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKgHRPRWIGVGALLMGLGSLLFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 92 LTSYIFLWFPLrFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIW------------ 159
Cdd:pfam03137 85 LPHFLSFFLGQ-LLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYvdigkvsitltp 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 160 ---NWQGAW----IGLGIISFSLAILVW---------KWLREDSRHTIQQPKSTIQATSHRKS----------------- 206
Cdd:pfam03137 164 kdpRWVGAWwlgfLIAGLLLLLTAIPFFffpkslpgaAKRRAKKKKEPHSQDIADLKKTKSLKklgpslkdfpkalkrll 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 207 ----YLFwLILAYGFEGFGYIITGTFLVTIVERI-TLSPFYAScswIIVGIAVIPSS----YLWSTVARKYGPtRALTSA 277
Cdd:pfam03137 244 knpvYML-LTLASVFEFLLIAGYATFLPKYIETQfGLSASTAN---LLTGVVAIPGAalgiLLGGLIIKKFKL-SAKGLA 318
|
330
....*....|....*...
gi 446587975 278 YMLQIISVLSPLLIPNLF 295
Cdd:pfam03137 319 KFNVITSLVSLLLSLLLF 336
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
161-315 |
3.46e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.59 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 161 WQGAWIGLGIISFSLAILVWKWLREDSRHTIQQP-----KSTIQATSHRKSYLfWLILAYGFEGFGYIITGTFLVTIVER 235
Cdd:cd17332 172 YFLTALIIGIIGIILLLICFFGTRERVVPPEEEKsklplLKSLKALLKNRPFL-ILLLAYLLYFLAFNIVNTVLVYYFKY 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 236 ITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYMLQIISVLSPLLIP--NLFGAFLSAFLLGATFVGITI 313
Cdd:cd17332 251 VLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGYGGANL 330
|
..
gi 446587975 314 LT 315
Cdd:cd17332 331 LP 332
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
84-360 |
5.28e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 5.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 84 VLSTLCMGL----TSYIFLWFPLRFIGGFTSAIVFvLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFsgsFAPLFNSIW 159
Cdd:cd17352 76 LLAALGLLLssfaTSLWQLYLTYGVLGGLGLGLIY-SPAIVIVGQYFEKKRGLATGIAVAGSGVGTFV---FPPLLRYLL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 160 N---WQGAWIGLGIISFSLAILVwkwlredsrhtiqqpkSTIQATSHRK--SYLFWLILAYgfegFGYIITGTFLVTIVE 234
Cdd:cd17352 152 DnygWRGALLILGGLCLNLCVCG----------------LLLRLLKDPTfvLLALGVSFAM----LGFFVPFVYLPSYAK 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 235 RITLSPFYASCSWIIVGIAVIPSSYLWSTVARKYGPTRALTSAYmLQIISVLSPLLIP---NLFGAFLSAFLLGATFVGI 311
Cdd:cd17352 212 SLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF-TLLILGLSLLAFPlatTYVGLIVFSVLFGFCSGSY 290
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446587975 312 TILTT-TEAKRIRPNESNKIIGYTTGVYGIGQIIGPIFTGIIAEQMQSFS 360
Cdd:cd17352 291 SSLTPvILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYD 340
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-217 |
5.52e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.84 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 19 AVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIKNREKILHhclffnVLSTLCMGLTSYIFL 98
Cdd:cd17475 6 AAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVL------AVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 99 W-------FPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGLGII 171
Cdd:cd17475 80 LvgsypvlLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 446587975 172 SFSLAILVWKWLREDSRHTIQQPKSTIQATS---HRKSYLFWLILAYGF 217
Cdd:cd17475 160 SILAAVLFWLFYREPPAASAATESASTLLRSlkeVLRNRDVWLIAIAGA 208
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-183 |
3.97e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 3.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 11 IAGICSLIAVMGISRFAYTPIIS-FMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFITIK-NREKILHHCLFFNVLSTL 88
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRiGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 89 CMGLTSYIFLWFPLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIWNWQGAWIGL 168
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|....*
gi 446587975 169 GIISFSLAILVWKWL 183
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
8-295 |
5.38e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 38.76 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 8 KMIIAGICSLIAVMGISRFAYTPIISFMEKQAHIEDDLAGYLASSNYLGYLLGAFFIGFI-TIKNREKILHHCLFFNVLS 86
Cdd:cd17336 2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFgGRGHRPRWIGIGSILMGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 87 TLCMGLTSYIFLwfpLRFIGGFTSAIVFVLASSIVLDYLFQSNKVMLGGMIYSGVGIGIIFSGSFAPLFNSIW------- 159
Cdd:cd17336 82 CFLLALPHFLFV---GQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYvdfsrvp 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446587975 160 --------NWQGA-WIG---LGIISFSLAILVWKWlredsrhtiqqPKStiqatshrksyLFWLILAYGFEGFGYIITGT 227
Cdd:cd17336 159 lgitpddpRWIGAwWLGfliLGILLLIVSIPLFFF-----------PPI-----------FILLLLAIVFESFAISGFST 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446587975 228 FLVTIVERIT-LSPFYAScswIIVGIAVIPSS----YLWSTVARKYGPTRALTSAYMLQIISVLSPLLIPNLF 295
Cdd:cd17336 217 FLPKYLETQFrLSASLAS---LLTGLILVPGAalgiLLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFF 286
|
|
| ATP-synt_Fo_b |
cd06503 |
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ... |
9-46 |
7.37e-03 |
|
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.
Pssm-ID: 349951 [Multi-domain] Cd Length: 132 Bit Score: 36.26 E-value: 7.37e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 446587975 9 MIIAGICSLIAVMGI-SRFAYTPIISFMEK-QAHIEDDLA 46
Cdd:cd06503 1 TLIWQIINFLILLFIlKKFLWKPILKALDErEEKIAESLE 40
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|
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