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Conserved domains on  [gi|446591657|ref|WP_000669003|]
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MULTISPECIES: superantigen-like protein SSL1 [Staphylococcus]

Protein Classification

PRK13037 family protein( domain architecture ID 11486425)

PRK13037 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13037 PRK13037
superantigen-like protein SSL1; Reviewed;
1-226 3.69e-150

superantigen-like protein SSL1; Reviewed;


:

Pssm-ID: 106074  Cd Length: 226  Bit Score: 416.68  E-value: 3.69e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSEADLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQYNKI 80
Cdd:PRK13037   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKTEVKQQSESELKHYYNKPVLERKNVTGYKYTEKGKDYIDVIVDNQYSQI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  81 SLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSSLYQIYKEDISLK 160
Cdd:PRK13037  81 SLVGSDKDKFKDGDNSNIDVFILREGDSRQATNYSIGGVTKTNSQPYIDYIHTPILEIKKGKEEPQSSLYQIYKEDISLK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446591657 161 ELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13037 161 ELDYRLRERAIKQHGLYSNGLKQGQITITMKDGKSHTIDLSQKLEKERMGESIDGRQIQKILVEMK 226
 
Name Accession Description Interval E-value
PRK13037 PRK13037
superantigen-like protein SSL1; Reviewed;
1-226 3.69e-150

superantigen-like protein SSL1; Reviewed;


Pssm-ID: 106074  Cd Length: 226  Bit Score: 416.68  E-value: 3.69e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSEADLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQYNKI 80
Cdd:PRK13037   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKTEVKQQSESELKHYYNKPVLERKNVTGYKYTEKGKDYIDVIVDNQYSQI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  81 SLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSSLYQIYKEDISLK 160
Cdd:PRK13037  81 SLVGSDKDKFKDGDNSNIDVFILREGDSRQATNYSIGGVTKTNSQPYIDYIHTPILEIKKGKEEPQSSLYQIYKEDISLK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446591657 161 ELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13037 161 ELDYRLRERAIKQHGLYSNGLKQGQITITMKDGKSHTIDLSQKLEKERMGESIDGRQIQKILVEMK 226
SSL_OB pfam09199
Staphylococcal superantigen-like OB-fold domain; This OB-fold domain folds into a ...
 41-123 3.14e-24

Staphylococcal superantigen-like OB-fold domain; This OB-fold domain folds into a five-stranded beta-barrel. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) or superantigens. These SSL proteins of which 11 have so far been characterized have a typical SE tertiary structure consisting of a distinct oligonucleotide/oligosaccharide binding (OB-fold), this domain, linked to a beta-grasp domain, family Stap_Strp_tox_C, pfam02876. SSLs do not bind to T-cell receptors or major histocompatibility complex class II molecules and do not stimulate T cells. SSLs target components of innate immunity, such as complement, Fc receptors, and myeloid cells 2,3,4,5,6,7,8]. SSL protein 7 (SSL7) is the best characterized of the SSLs and binds complement factor C5 and IgA with high affinity and inhibits the end stage of complement activation and IgA binding to FcalphaR.


Pssm-ID: 401224 [Multi-domain]  Cd Length: 84  Bit Score: 91.60  E-value: 3.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   41 DLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQYNKISLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVT 120
Cdd:pfam09199   2 DLKAYYSKPSFELKNVSGYKEKKTGKNFLNFTPNNQKYQVALLGKDKEKYKEGEHDNLDVFVVRELEDRNGRKYSVGGVT 81


                  ...
gi 446591657  121 KTN 123
Cdd:pfam09199  82 KKN 84
 
Name Accession Description Interval E-value
PRK13037 PRK13037
superantigen-like protein SSL1; Reviewed;
1-226 3.69e-150

superantigen-like protein SSL1; Reviewed;


Pssm-ID: 106074  Cd Length: 226  Bit Score: 416.68  E-value: 3.69e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSEADLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQYNKI 80
Cdd:PRK13037   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKTEVKQQSESELKHYYNKPVLERKNVTGYKYTEKGKDYIDVIVDNQYSQI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  81 SLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSSLYQIYKEDISLK 160
Cdd:PRK13037  81 SLVGSDKDKFKDGDNSNIDVFILREGDSRQATNYSIGGVTKTNSQPYIDYIHTPILEIKKGKEEPQSSLYQIYKEDISLK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446591657 161 ELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13037 161 ELDYRLRERAIKQHGLYSNGLKQGQITITMKDGKSHTIDLSQKLEKERMGESIDGRQIQKILVEMK 226
PRK13036 PRK13036
superantigen-like protein SSL11; Reviewed;
1-225 3.61e-61

superantigen-like protein SSL11; Reviewed;


Pssm-ID: 171852  Cd Length: 227  Bit Score: 191.31  E-value: 3.61e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQA-KAEVKQQSEADLKLYYSGPSFEYKKVTGYGFvEGKDRFIDfiyNGQYNK 79
Cdd:PRK13036   1 MKLKNIAKASLALGILTTGMITTTAQPVKAsTLEVRSQATQDLSEYYKGRGFELTNVSGYKE-GNKVTFID---NSQLID 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  80 ISLVGSDKDKYNEEVN-PDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEE----PQSSLYQIYK 154
Cdd:PRK13036  77 VTLTGNEKLTFKDDEDvSNVDVFVVREGSDKSAITTSIGGITKTNGTQYKDTVQNVNLSISKSTGQhttsVTSEYYSINK 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446591657 155 EDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEM 225
Cdd:PRK13036 157 EEISLKELDFKLRKHLIDKHDLYKTEPKDSKIRITMKNGGYYTFELNKKLQPHRMGDTIDSRNIEKIEVNL 227
PRK13035 PRK13035
superantigen-like protein SSL5; Reviewed;
1-226 5.21e-51

superantigen-like protein SSL5; Reviewed;


Pssm-ID: 171851  Cd Length: 234  Bit Score: 165.62  E-value: 5.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSV-----QAKAEVKQQSEADLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNG 75
Cdd:PRK13035   1 MKMAAIAKASLALGILATGTITSLHQTVnasehEAKYENVTKDIFDLRDYYSGASKELKNVTGYRYSKGGKHYLIFDKNR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  76 QYNKISLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSS---LYQI 152
Cdd:PRK13035  81 KFTRVQIFGKDIERFKARKNPGLDIFVVKEAENRNGTVFSYGGVTKKNQDAYYDYINAPRFQIKRDEGDGIATygrVHYI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446591657 153 YKEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13035 161 YKEEISLKELDFKLRQYLIQNFDLYKKFPKDSKIKVIMKDGGYYTFELNKKLQTNRMSDVIDGRNIEKIEANIR 234
PRK13346 PRK13346
superantigen-like protein SSL7; Reviewed;
1-226 1.81e-45

superantigen-like protein SSL7; Reviewed;


Pssm-ID: 106304 [Multi-domain]  Cd Length: 231  Bit Score: 151.31  E-value: 1.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSE----ADLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQ 76
Cdd:PRK13346   1 MKLKTLAKATLALGLLTTGVITSEGQAVQAKEKQERVQHlydiKDLHRYYSSESFEFSNISGKVENYNGSNVVRFNQENQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  77 YNKISLVGSDKDKYNEEVNPDiDVFVVRE---GNGRQAdnhSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSSLYQIY 153
Cdd:PRK13346  81 NHQLFLLGKDKDKYKEGLEGQ-NVFVVKElidPNGRLS---TVGGVTKKNNKSSETNTHLFVNKVYGGNLDASIDSFLIN 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446591657 154 KEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13346 157 KEEVSLKELDFKIRQQLVENYGLYKGTTKYGKITINLKDEKKEEIDLGDKLQFERMGDVLNSKDIQNIAVTIN 229
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
1-226 1.78e-42

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 145.16  E-value: 1.78e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQA------KAEVKQ------QSEA---------------------------- 40
Cdd:PRK13042   1 MKITTIAKTSLALGLLTTGVITTTTQAANAttpsstKVEAPQstppstKVEApqskpnattppstkveapqqtpnattps 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  41 ------------------------DLKLYYSGPSFEYKKvtGYGFVEGK---DRFIDFIYNGQYNKISLVGSDKDKYNEE 93
Cdd:PRK13042  81 stkvetpqspttkqvpteinpkfkDLRAYYTKPSLEFKN--EIGIILKKwttIRFMNVVPDYFIYKIALVGKDDKKYGEG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  94 VNPDIDVFVVREGNGRQADNHSIGGVTKTN-RGVYYDYIHTPILEIKKGKEEPQSSLYQIYKEDISLKELDYRLRERAIK 172
Cdd:PRK13042 159 VHRNVDVFVVLEENKYNLEKYSVGGITKSNsKKVDHKAGVRITKEDNKGTISHDVSEFKITKEQISLKELDFKLRKQLIE 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446591657 173 HHGLYSKgLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13042 239 KHNLYGN-VGSGKIVIKMKNGGKYTFELHKKLQENRMADVIDGTNIDNIEVNIK 291
PRK13038 PRK13038
superantigen-like protein SSL10; Reviewed;
1-226 1.70e-41

superantigen-like protein SSL10; Reviewed;


Pssm-ID: 171853  Cd Length: 227  Bit Score: 140.92  E-value: 1.70e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSEAD---LKLYYSGPSFEYKKVTGygFVEGKDRfIDFIYNGQY 77
Cdd:PRK13038   1 MKFTALAKATLALGILTTGTLTTEVHSGHAKQNQKSVNKHDkeaLYRYYTGKTMEMKNISA--LKHGKNN-LRFKFRGIK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  78 NKISLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVyyDYIHTPILEIKKGKEEP---QSSLYQIYK 154
Cdd:PRK13038  78 IQVLLPGNDKSKFQQRSYEGLDVFFVQEKRDKHDIFYTVGGVIQNNKTS--GVVSAPILNISKEKGEDafvKGYPYYIKK 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446591657 155 EDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13038 156 EKITLKELDYKLRKHLIEKYGLYKTISKDGRVKISLKDGSFYNLDLRSKLKFKYMGEVIESKQIKDIEVNLK 227
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
29-226 4.42e-41

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 143.34  E-value: 4.42e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  29 QAKAEVKQQSEaDLKLYYSGPSFEYKKvtGYGFVEGK---DRFIDFIYNGQYNKISLVGSDKDKYNEEVNPDIDVFVVRE 105
Cdd:PRK13335 159 QAQTDMTPKYE-DLRAYYTKPSFEFEK--QFGFLLKPwttVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLE 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657 106 GNGRQADNHSIGGVTKTNR-GVYYDYIHTPILEIKKGKEEPQSSLYQIYKEDISLKELDYRLRERAIKHHGLYSKgLKQG 184
Cdd:PRK13335 236 DNKYQLKKYSVGGITKTNSkKVDHKAELSITKKDNQGMISRDVSEYMITKEEISLKELDFKLRKQLIEKHNLYGN-MGSG 314

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446591657 185 QITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13335 315 TIVIKMKNGGKYTFELHKKLQEHRMADVIDGTNIDKIEVNIK 356
PRK13041 PRK13041
superantigen-like protein SSL2; Reviewed;
1-226 5.49e-40

superantigen-like protein SSL2; Reviewed;


Pssm-ID: 106078  Cd Length: 231  Bit Score: 137.07  E-value: 5.49e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQA--KAEVKQQSEADLKLYYSGPSFEYKKVTGY-GFVEGKDRFIDFIYNGQY 77
Cdd:PRK13041   1 MKMKNIAKISLLLGILATGVNTTTEKPVHAekKPIVISENSKKLKAYYTQPSIEYKNVTGYiSFIQPSIKFMNIIDGNSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  78 NKISLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVyYDYIHTP--ILEIKKGKEEPQSSLYQIYKE 155
Cdd:PRK13041  81 NNLALIGKDKQHYHTGVHRNLNIFYVNEDKRFEGAKYSIGGITSANDKA-VDLIAEArvIKADHIGEYDYDFFPFKIDKE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446591657 156 DISLKELDYRLRERAIKHHGLYSKgLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13041 160 AMSLKEIDFKLRKYLIDNYGLYGE-MSTGKITVKKKYYGKYTFELDKKLQEDRMSDVINVTDIDRIEIKVR 229
PRK13040 PRK13040
superantigen-like protein SSL6; Reviewed;
1-226 6.62e-36

superantigen-like protein SSL6; Reviewed;


Pssm-ID: 106077  Cd Length: 231  Bit Score: 126.38  E-value: 6.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVK-QQSEADLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQYNK 79
Cdd:PRK13040   1 MKLKTLAKATLVLGLLATGVITTESQTVKAAESTQgQHNYKSLKYYYSKPSIELKNLDGLYRQKVTDKGVYVWKDRKDYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  80 ISLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPIL-EIKKGKEEPQSSLYQIYKEDIS 158
Cdd:PRK13040  81 VGLLGKDIEKYPQGEHDKQDAFLVIEEETVNGRQYSIGGLSKTNSKEFSKEVDVKVTrKIDESSEKSKDSKFKITKEEIS 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446591657 159 LKELDYRLRERAIKHHGLYSK-GLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13040 161 LKELDFKLRKKLMEEEKLYGAvNNRKGKIVVKMEDDKFYTFELTKKLQPHRMGDTIDGTKIKEINVELE 229
PRK13345 PRK13345
superantigen-like protein SSL9; Reviewed;
1-225 2.78e-34

superantigen-like protein SSL9; Reviewed;


Pssm-ID: 106303  Cd Length: 232  Bit Score: 122.42  E-value: 2.78e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSEA----DLKLYYSGPSFEYKKVTgygfVEGKDRF----IDFI 72
Cdd:PRK13345   1 MKLTALAKATLALGILTTGVFTAESKAVHAKVELDETQRKyyinMLHQYYSEESFEPTNIS----VKSEDYYgsnvLNFK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  73 YNGQYNKISLVGSDKDKYNEEVNpDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSS---L 149
Cdd:PRK13345  77 QRNKAFKVFLLGDDKNKYKEKTH-GLDVFAVPELIDIKGGIYSVGGITKKNVRSVFGFVSNPSLQVKKVDAKHGFSineL 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446591657 150 YQIYKEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEM 225
Cdd:PRK13345 156 FFIQKEEVSLKELDFKIRKMLVEKYRLYKGASDKGRIVINMKDEKKYVIDLSEKLSFDRMFDVMDSKQIKNIEVNL 231
PRK13039 PRK13039
superantigen-like protein SSL8; Reviewed;
1-226 6.04e-33

superantigen-like protein SSL8; Reviewed;


Pssm-ID: 171854  Cd Length: 232  Bit Score: 119.03  E-value: 6.04e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSEA----DLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQ 76
Cdd:PRK13039   1 MKFTAIAKAIFVLGILTTSVMITENQSVNAKGKYEKMNRLydtnKLHQYYSGPSYELTNVSGQSQGYYDSNVLLFNQQNQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  77 YNKISLVGSDKDKYNEEVNpDIDVFVVREGNGRQADNHSIGGVTKTNRGVYYDYIHTPILEIKKGKEEPQSS---LYQIY 153
Cdd:PRK13039  81 KFQVFLLGKDENKYKEKTH-GLDVFAVPELVDLDGRIFSVSGVTKKNVKSIFESLRTPNLLVKKIDDKDGFSideFFFIQ 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446591657 154 KEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDGTTHTIDLSQKLEKERMGQSVDGKQIQKILVEMK 226
Cdd:PRK13039 160 KEEVSLKELDFKIRKLLIKKYKLYEGSADKGRIVINMKDENKYEIDLSDKLDFERMADVINSEQIKNIEVNLK 232
SSL_OB pfam09199
Staphylococcal superantigen-like OB-fold domain; This OB-fold domain folds into a ...
 41-123 3.14e-24

Staphylococcal superantigen-like OB-fold domain; This OB-fold domain folds into a five-stranded beta-barrel. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) or superantigens. These SSL proteins of which 11 have so far been characterized have a typical SE tertiary structure consisting of a distinct oligonucleotide/oligosaccharide binding (OB-fold), this domain, linked to a beta-grasp domain, family Stap_Strp_tox_C, pfam02876. SSLs do not bind to T-cell receptors or major histocompatibility complex class II molecules and do not stimulate T cells. SSLs target components of innate immunity, such as complement, Fc receptors, and myeloid cells 2,3,4,5,6,7,8]. SSL protein 7 (SSL7) is the best characterized of the SSLs and binds complement factor C5 and IgA with high affinity and inhibits the end stage of complement activation and IgA binding to FcalphaR.


Pssm-ID: 401224 [Multi-domain]  Cd Length: 84  Bit Score: 91.60  E-value: 3.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   41 DLKLYYSGPSFEYKKVTGYGFVEGKDRFIDFIYNGQYNKISLVGSDKDKYNEEVNPDIDVFVVREGNGRQADNHSIGGVT 120
Cdd:pfam09199   2 DLKAYYSKPSFELKNVSGYKEKKTGKNFLNFTPNNQKYQVALLGKDKEKYKEGEHDNLDVFVVRELEDRNGRKYSVGGVT 81


                  ...
gi 446591657  121 KTN 123
Cdd:pfam09199  82 KKN 84
PRK13350 PRK13350
superantigen-like protein SSL12; Reviewed;
1-226 3.32e-12

superantigen-like protein SSL12; Reviewed;


Pssm-ID: 171995 [Multi-domain]  Cd Length: 238  Bit Score: 63.83  E-value: 3.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657   1 MKFKAIAKASLALGMLATGVITSNVQ------SVQAKAEVKQQSEA---DLKLYYSGP--SFEYKKVTGYG----FVEGK 65
Cdd:PRK13350   1 MSKNITKNIILTTTLLLLGTVLPQNQkpvfsfYSEAKAYSIGQDETninELIKYYTQPhfSFSNKWLYQYDngniYVELK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657  66 DR----FIDFIYNGQYNKISLVgsdKDKYneevnpdIDVFVVREGNGRQA----DNHSIGGVTKTNRGVYYDYihtPILE 137
Cdd:PRK13350  81 RYswsaHISLWGAESWGNINQL---KDRY-------VDVFGLKDKDTDQLwwsyRETFTGGVTPAAKPSDKTY---NLFV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657 138 IKKGKEEPQSSLYQIY---KEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITmNDGTTHTIDLSQKLEKERMGQSVD 214
Cdd:PRK13350 148 QYKDKLQTIIGAHKIYqgnKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKIT-GGGNNYTIDLSKRLHSDLANVYVK 226

                        250
                 ....*....|..
gi 446591657 215 GKQIQKILVEMK 226
Cdd:PRK13350 227 NPNKITVDVLFD 238
PRK13043 PRK13043
superantigen-like protein SSL14; Reviewed;
149-205 1.86e-07

superantigen-like protein SSL14; Reviewed;


Pssm-ID: 171855  Cd Length: 241  Bit Score: 50.09  E-value: 1.86e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446591657 149 LYQIYKEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITmNDGTTHTIDLSQKLE 205
Cdd:PRK13043 162 FYKGNKPVLTLKELDFRIRQTLIKNKKLYNGEFNKGQIKIT-ADGNNYTIDLSKKLK 217
PRK13349 PRK13349
superantigen-like protein SSL13; Reviewed;
140-223 3.54e-07

superantigen-like protein SSL13; Reviewed;


Pssm-ID: 106307  Cd Length: 241  Bit Score: 49.29  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446591657 140 KGKEEPQSSLYQIY---KEDISLKELDYRLRERAIKHHGLYSKGLKQGQITITMNDgTTHTIDLSQKLEKERMGQSVDGK 216
Cdd:PRK13349 150 KDKAETFTGGFPVYegnKPVLTLKELDFRIRQTLIKSKKLYNNSYNKGQIKITGAD-NNYTIDLSKRLPSTDANRYVKKP 228


                 ....*..
gi 446591657 217 QIQKILV 223
Cdd:PRK13349 229 QNAKIEV 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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