|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1-1044 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 1172.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYM 80
Cdd:COG0841 1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 81 NTQmAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQkrYDSLYLSNFA 160
Cdd:COG0841 81 TST-SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDD--LDELELSDYA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 161 IRQVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQpeasaAFQMTVNTLG 240
Cdd:COG0841 158 ERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGG-----DREYTVRTNG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 241 RLTSEEQFGEIVVKIGaDGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFP 320
Cdd:COG0841 233 RLKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 321 QDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGL 400
Cdd:COG0841 312 EGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFAL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 401 VLSIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:COG0841 392 VLAIGIVVDDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALL 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAKadwltrlmgtvtGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:COG0841 472 ISLFVALTLTPALCARLLKPHPKGKK------------GRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLAL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGPvnVPNSALMFAML 640
Cdd:COG0841 540 SVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGS--GSNSGTIFVTL 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 641 KPFDEREdpsLSANAIAGKLMHKFSHIPDGFIGIFPPPPvPGLGATGGFKLQIEDRaelGFEAMTKVQSEIMSKAMQTPE 720
Cdd:COG0841 618 KPWDERD---RSADEIIARLREKLAKIPGARVFVFQPPA-GGLGSGAPIEVQLQGD---DLEELAAAAEKLLAALRQIPG 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 721 LANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKVR 800
Cdd:COG0841 691 LVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVR 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 801 NAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIV-RETLPEGMVFEWTDLVYQEKQAG 879
Cdd:COG0841 771 TPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAaELKLPPGVSIEFTGQAEEEQESF 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 880 NSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFAR 959
Cdd:COG0841 851 SSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN 930
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 960 AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:COG0841 931 QLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDR 1010
|
....*
gi 446595807 1040 MALKR 1044
Cdd:COG0841 1011 LRRRL 1015
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
3-1038 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 1082.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 3 FTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNT 82
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 83 QMAiDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIR 162
Cdd:pfam00873 81 QSS-YGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 163 QVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGS-VGQQpeasaaFQMTVNTLGR 241
Cdd:pfam00873 160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQlEGQG------LQALIRAQGQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 242 LTSEEQFGEIVVKiGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQ 321
Cdd:pfam00873 234 LQSAEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQ 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 322 DIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLV 401
Cdd:pfam00873 313 GVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 402 LSIGIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:pfam00873 393 LAIGLVVDDAIVVVENIERVLEeNGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAIL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAKadwltrlmgtvtGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:pfam00873 473 LSVLVALTLTPALCATLLKPRREPKH------------GGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVG 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAML 640
Cdd:pfam00873 541 SVWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSGDNNGPNSGDAFISL 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 641 KPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIED-RAELGFEAMTKVQSEIMSKAMQTP 719
Cdd:pfam00873 621 KPWKERPGPEKSVQALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVkIFGDDLDALDEARNQILAALAQLP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 720 ELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKV 799
Cdd:pfam00873 701 GLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYV 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 800 RNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVRE-TLPEGMVFEWTDLVYQEKQA 878
Cdd:pfam00873 781 RNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQvKLPPGYGYTWTGQFEQEQLA 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 879 GNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA 958
Cdd:pfam00873 861 GNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFA 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 959 RAK-EHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVV 1037
Cdd:pfam00873 941 NELrEQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLF 1020
|
.
gi 446595807 1038 R 1038
Cdd:pfam00873 1021 H 1021
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
3-1040 |
0e+00 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 1070.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 3 FTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNT 82
Cdd:TIGR00915 1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 83 QMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIR 162
Cdd:TIGR00915 81 SSDSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 163 QVRDELARLPGVGDVLVWGAgEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEASA-AFQMTVNTLGR 241
Cdd:TIGR00915 161 NMVDPLSRLEGVGDVQLFGS-QYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPGqQLNATIIAQTR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 242 LTSEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQ 321
Cdd:TIGR00915 240 LQTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQ 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 322 DIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLV 401
Cdd:TIGR00915 320 GMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 402 LSIGIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:TIGR00915 400 LAIGLLVDDAIVVVENVERVMAeEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAKadwltrlmGTVTGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:TIGR00915 480 LSVLVALILTPALCATMLKPIEKGEH--------HEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGG 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPG--VESVVVFPGLSVNGpvNVPNSALMFA 638
Cdd:TIGR00915 552 MVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanVESVFTVNGFSFAG--RGQNMGMAFI 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 639 MLKPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQT 718
Cdd:TIGR00915 630 RLKDWEERTGKENSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQN 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 719 PELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLK 798
Cdd:TIGR00915 710 PALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWY 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 799 VRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVREtLPEGMVFEWTDLVYQEKQA 878
Cdd:TIGR00915 790 VRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQK-LPPGFGFSWTGMSYEERLS 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 879 GNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA 958
Cdd:TIGR00915 869 GSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFA 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 959 RAKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVR 1038
Cdd:TIGR00915 949 KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVR 1028
|
..
gi 446595807 1039 RM 1040
Cdd:TIGR00915 1029 RL 1030
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
6-1039 |
0e+00 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 864.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 6 FFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQMA 85
Cdd:PRK10555 4 FFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 86 IDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVR 165
Cdd:PRK10555 84 GTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 166 DELARLPGVGDVLVWGAgEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEA-SAAFQMTVNTLGRLTS 244
Cdd:PRK10555 164 DPLSRVNGVGDIDAYGS-QYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTPSVdKQALNATINAQSLLQT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 245 EEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQDIE 324
Cdd:PRK10555 243 PEQFRDITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 325 YRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSI 404
Cdd:PRK10555 323 YKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAI 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 405 GIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILSA 483
Cdd:PRK10555 403 GLLVDDAIVVVENVERIMSeEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSV 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 484 INSLTLSPALAAILLRP----HHDTAKadwltrlmgtvtgGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVG 559
Cdd:PRK10555 483 LVAMILTPALCATLLKPlkkgEHHGQK-------------GFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLG 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 560 LTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAM 639
Cdd:PRK10555 550 GMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKDNVMSVFATVGSGPGGNGQNVARMFIR 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 640 LKPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTP 719
Cdd:PRK10555 630 LKDWDERDSKTGTSFAIIERATKAFNKIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAKNP 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 720 ELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKV 799
Cdd:PRK10555 710 ELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYV 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 800 RNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVREtLPEGMVFEWTDLVYQEKQAG 879
Cdd:PRK10555 790 RNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQ-LPNGFGLEWTAMSYQERLSG 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 880 NSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFAR 959
Cdd:PRK10555 869 AQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFAN 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 960 AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:PRK10555 949 EMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFFVLVRR 1028
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
4-1039 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 764.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 4 THFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQ 83
Cdd:NF033617 1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 84 MAIdGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVqRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQ 163
Cdd:NF033617 81 SSL-GYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEA-PDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 164 VRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEAsaafqMTVNTLGRLT 243
Cdd:NF033617 159 LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVV-----STVRANDQLK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 244 SEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQDI 323
Cdd:NF033617 234 TAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 324 EYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLS 403
Cdd:NF033617 314 KVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 404 IGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILSA 483
Cdd:NF033617 394 IGLVVDDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 484 INSLTLSPALAAILLRPHHDTAKadwltrlmgtvtggFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGLTWL 563
Cdd:NF033617 474 IVALTLTPMMCSRLLKANEKPGR--------------FARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 564 GFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLsvnGPVNVPNSALMFAMLKPF 643
Cdd:NF033617 540 LYVFIPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV---GGNPGDNTGFGIINLKPW 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 644 DEREDpslSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGlGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTPELAN 723
Cdd:NF033617 617 DERDV---SAQEIIDRLRPKLAKVPGMDLFLFPLQDLPG-GAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFAD 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 724 MLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKVRNAK 803
Cdd:NF033617 693 VDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSND 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 804 GEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGNSAL 883
Cdd:NF033617 773 GKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLL 852
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 884 AIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA-RAKE 962
Cdd:NF033617 853 FLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFAnELQR 932
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446595807 963 HDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:NF033617 933 HQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1-1044 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 1172.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYM 80
Cdd:COG0841 1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 81 NTQmAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQkrYDSLYLSNFA 160
Cdd:COG0841 81 TST-SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDD--LDELELSDYA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 161 IRQVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQpeasaAFQMTVNTLG 240
Cdd:COG0841 158 ERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGG-----DREYTVRTNG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 241 RLTSEEQFGEIVVKIGaDGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFP 320
Cdd:COG0841 233 RLKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 321 QDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGL 400
Cdd:COG0841 312 EGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFAL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 401 VLSIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:COG0841 392 VLAIGIVVDDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALL 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAKadwltrlmgtvtGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:COG0841 472 ISLFVALTLTPALCARLLKPHPKGKK------------GRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLAL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGPvnVPNSALMFAML 640
Cdd:COG0841 540 SVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGS--GSNSGTIFVTL 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 641 KPFDEREdpsLSANAIAGKLMHKFSHIPDGFIGIFPPPPvPGLGATGGFKLQIEDRaelGFEAMTKVQSEIMSKAMQTPE 720
Cdd:COG0841 618 KPWDERD---RSADEIIARLREKLAKIPGARVFVFQPPA-GGLGSGAPIEVQLQGD---DLEELAAAAEKLLAALRQIPG 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 721 LANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKVR 800
Cdd:COG0841 691 LVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVR 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 801 NAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIV-RETLPEGMVFEWTDLVYQEKQAG 879
Cdd:COG0841 771 TPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAaELKLPPGVSIEFTGQAEEEQESF 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 880 NSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFAR 959
Cdd:COG0841 851 SSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN 930
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 960 AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:COG0841 931 QLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDR 1010
|
....*
gi 446595807 1040 MALKR 1044
Cdd:COG0841 1011 LRRRL 1015
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
3-1038 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 1082.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 3 FTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNT 82
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 83 QMAiDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIR 162
Cdd:pfam00873 81 QSS-YGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 163 QVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGS-VGQQpeasaaFQMTVNTLGR 241
Cdd:pfam00873 160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQlEGQG------LQALIRAQGQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 242 LTSEEQFGEIVVKiGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQ 321
Cdd:pfam00873 234 LQSAEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQ 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 322 DIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLV 401
Cdd:pfam00873 313 GVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 402 LSIGIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:pfam00873 393 LAIGLVVDDAIVVVENIERVLEeNGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAIL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAKadwltrlmgtvtGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:pfam00873 473 LSVLVALTLTPALCATLLKPRREPKH------------GGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVG 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAML 640
Cdd:pfam00873 541 SVWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSGDNNGPNSGDAFISL 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 641 KPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIED-RAELGFEAMTKVQSEIMSKAMQTP 719
Cdd:pfam00873 621 KPWKERPGPEKSVQALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVkIFGDDLDALDEARNQILAALAQLP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 720 ELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKV 799
Cdd:pfam00873 701 GLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYV 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 800 RNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVRE-TLPEGMVFEWTDLVYQEKQA 878
Cdd:pfam00873 781 RNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQvKLPPGYGYTWTGQFEQEQLA 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 879 GNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA 958
Cdd:pfam00873 861 GNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFA 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 959 RAK-EHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVV 1037
Cdd:pfam00873 941 NELrEQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLF 1020
|
.
gi 446595807 1038 R 1038
Cdd:pfam00873 1021 H 1021
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
3-1040 |
0e+00 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 1070.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 3 FTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNT 82
Cdd:TIGR00915 1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 83 QMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIR 162
Cdd:TIGR00915 81 SSDSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 163 QVRDELARLPGVGDVLVWGAgEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEASA-AFQMTVNTLGR 241
Cdd:TIGR00915 161 NMVDPLSRLEGVGDVQLFGS-QYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPGqQLNATIIAQTR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 242 LTSEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQ 321
Cdd:TIGR00915 240 LQTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQ 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 322 DIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLV 401
Cdd:TIGR00915 320 GMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 402 LSIGIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:TIGR00915 400 LAIGLLVDDAIVVVENVERVMAeEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAKadwltrlmGTVTGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:TIGR00915 480 LSVLVALILTPALCATMLKPIEKGEH--------HEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGG 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPG--VESVVVFPGLSVNGpvNVPNSALMFA 638
Cdd:TIGR00915 552 MVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanVESVFTVNGFSFAG--RGQNMGMAFI 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 639 MLKPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQT 718
Cdd:TIGR00915 630 RLKDWEERTGKENSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQN 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 719 PELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLK 798
Cdd:TIGR00915 710 PALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWY 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 799 VRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVREtLPEGMVFEWTDLVYQEKQA 878
Cdd:TIGR00915 790 VRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQK-LPPGFGFSWTGMSYEERLS 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 879 GNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA 958
Cdd:TIGR00915 869 GSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFA 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 959 RAKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVR 1038
Cdd:TIGR00915 949 KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVR 1028
|
..
gi 446595807 1039 RM 1040
Cdd:TIGR00915 1029 RL 1030
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
6-1039 |
0e+00 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 864.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 6 FFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQMA 85
Cdd:PRK10555 4 FFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 86 IDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVR 165
Cdd:PRK10555 84 GTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 166 DELARLPGVGDVLVWGAgEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEA-SAAFQMTVNTLGRLTS 244
Cdd:PRK10555 164 DPLSRVNGVGDIDAYGS-QYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTPSVdKQALNATINAQSLLQT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 245 EEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQDIE 324
Cdd:PRK10555 243 PEQFRDITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 325 YRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSI 404
Cdd:PRK10555 323 YKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAI 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 405 GIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILSA 483
Cdd:PRK10555 403 GLLVDDAIVVVENVERIMSeEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSV 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 484 INSLTLSPALAAILLRP----HHDTAKadwltrlmgtvtgGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVG 559
Cdd:PRK10555 483 LVAMILTPALCATLLKPlkkgEHHGQK-------------GFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLG 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 560 LTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAM 639
Cdd:PRK10555 550 GMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKDNVMSVFATVGSGPGGNGQNVARMFIR 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 640 LKPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTP 719
Cdd:PRK10555 630 LKDWDERDSKTGTSFAIIERATKAFNKIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAKNP 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 720 ELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKV 799
Cdd:PRK10555 710 ELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYV 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 800 RNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVREtLPEGMVFEWTDLVYQEKQAG 879
Cdd:PRK10555 790 RNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQ-LPNGFGLEWTAMSYQERLSG 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 880 NSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFAR 959
Cdd:PRK10555 869 AQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFAN 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 960 AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:PRK10555 949 EMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFFVLVRR 1028
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
6-1051 |
0e+00 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 852.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 6 FFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQMA 85
Cdd:PRK15127 4 FFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 86 IDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVR 165
Cdd:PRK15127 84 STGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 166 DELARLPGVGDVLVWGAgEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEASAAfQMTVNTLG--RLT 243
Cdd:PRK15127 164 DPISRTSGVGDVQLFGS-QYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQ-QLNASIIAqtRLT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 244 SEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQDI 323
Cdd:PRK15127 242 STEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 324 EYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLS 403
Cdd:PRK15127 322 KIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 404 IGIVVDDAIVVVENVERHIS-QGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILS 482
Cdd:PRK15127 402 IGLLVDDAIVVVENVERVMAeEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALS 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 483 AINSLTLSPALAAILLRPhhdTAKADwltrlMGTVTGGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFV-GLT 561
Cdd:PRK15127 482 VLVALILTPALCATMLKP---IAKGD-----HGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVvGMA 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 562 WLgFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEP--GVESVVVFPGLSVNGpvNVPNSALMFAM 639
Cdd:PRK15127 554 YL-FVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEknNVESVFAVNGFGFAG--RGQNTGIAFVS 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 640 LKPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTP 719
Cdd:PRK15127 631 LKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKHP 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 720 ElanMLASFQTNA----PQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIG 795
Cdd:PRK15127 711 D---MLVGVRPNGledtPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIG 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 796 LLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVREtLPEGMVFEWTDLVYQE 875
Cdd:PRK15127 788 DWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASK-LPTGVGYDWTGMSYQE 866
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 876 KQAGNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIV 955
Cdd:PRK15127 867 RLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIV 946
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 956 EFAR-AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFY 1034
Cdd:PRK15127 947 EFAKdLMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFF 1026
|
1050
....*....|....*...
gi 446595807 1035 VVV-RRMALKRENRVDSH 1051
Cdd:PRK15127 1027 VVVrRRFSRKNEDIEHSH 1044
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
6-1040 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 827.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 6 FFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQMA 85
Cdd:PRK09577 4 FFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 86 iDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVR 165
Cdd:PRK09577 84 -AGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVEKAADNIQLIVSLTSDDGRLTGVELGEYASANVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 166 DELARLPGVGDVLVWGAgEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQ--PEaSAAFQMTVNTLGRLT 243
Cdd:PRK09577 163 QALRRVEGVGKVQFWGA-EYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSavPD-SAPIAATVFADAPLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 244 SEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQDI 323
Cdd:PRK09577 241 TPEDFGAIALRARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 324 EYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLS 403
Cdd:PRK09577 321 KYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 404 IGIVVDDAIVVVENVERHISQ-GKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILS 482
Cdd:PRK09577 401 IGILVDDAIVVVENVERLMVEeGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFS 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 483 AINSLTLSPALAAILLRP----HHDTAkadwltrlmgtvtgGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFV 558
Cdd:PRK09577 481 AFLALSLTPALCATLLKPvdgdHHEKR--------------GFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALT 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 559 GLTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNGpvNVPNSALMFA 638
Cdd:PRK09577 547 AAAALLFTRLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYG--EGPNGGMIFV 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 639 MLKPFDEREDPSLSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQT 718
Cdd:PRK09577 625 TLKDWKERKAARDHVQAIVARINERFAGTPNTTVFAMNSPALPDLGSTSGFDFRLQDRGGLGYAAFVAAREQLLAEGAKD 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 719 PELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLK 798
Cdd:PRK09577 705 PALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLR 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 799 VRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVReTLPEGMVFEWTDLVYQEKQA 878
Cdd:PRK09577 785 VRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAA-TLPAGIGYAWSGQSFEERLS 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 879 GNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA 958
Cdd:PRK09577 864 GAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVA 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 959 RAKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVR 1038
Cdd:PRK09577 944 KDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFFVVVG 1023
|
..
gi 446595807 1039 RM 1040
Cdd:PRK09577 1024 RL 1025
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
4-1039 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 764.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 4 THFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQ 83
Cdd:NF033617 1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 84 MAIdGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVqRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQ 163
Cdd:NF033617 81 SSL-GYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEA-PDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 164 VRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEAsaafqMTVNTLGRLT 243
Cdd:NF033617 159 LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVV-----STVRANDQLK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 244 SEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQDI 323
Cdd:NF033617 234 TAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 324 EYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLS 403
Cdd:NF033617 314 KVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 404 IGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILSA 483
Cdd:NF033617 394 IGLVVDDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 484 INSLTLSPALAAILLRPHHDTAKadwltrlmgtvtggFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGLTWL 563
Cdd:NF033617 474 IVALTLTPMMCSRLLKANEKPGR--------------FARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 564 GFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLsvnGPVNVPNSALMFAMLKPF 643
Cdd:NF033617 540 LYVFIPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV---GGNPGDNTGFGIINLKPW 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 644 DEREDpslSANAIAGKLMHKFSHIPDGFIGIFPPPPVPGlGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTPELAN 723
Cdd:NF033617 617 DERDV---SAQEIIDRLRPKLAKVPGMDLFLFPLQDLPG-GAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFAD 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 724 MLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKVRNAK 803
Cdd:NF033617 693 VDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSND 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 804 GEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGNSAL 883
Cdd:NF033617 773 GKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLL 852
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 884 AIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA-RAKE 962
Cdd:NF033617 853 FLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFAnELQR 932
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446595807 963 HDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:NF033617 933 HQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
1-1039 |
2.05e-179 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 550.59 E-value: 2.05e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYM 80
Cdd:PRK09579 1 MAFTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 81 nTQMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPDMLMVVHLVSpqKRYDSLYLSNFA 160
Cdd:PRK09579 81 -TSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISFYS--EEMSNPQITDYL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 161 IRQVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEASaafqmTVNTLG 240
Cdd:PRK09579 158 SRVIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVT-----SINAST 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 241 RLTSEEQFGEIVVKIGADGEVtRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFP 320
Cdd:PRK09579 233 ELKSAEAFAAIPVKTSGDSRV-LLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 321 QDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGL 400
Cdd:PRK09579 312 PNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAM 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 401 VLSIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480
Cdd:PRK09579 392 VLAIGLVVDDAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVI 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 481 LSAINSLTLSPALAAILLRPHHDTAkadwltrlmgtvtgGFFHRFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGL 560
Cdd:PRK09579 472 ISGIVALTLSPMMCALLLRHEENPS--------------GLAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLAL 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 561 TWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESvvvfpGLSVNGpVNVPNSALMFAML 640
Cdd:PRK09579 538 IPVLLKFTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYS-----SFQING-FNGVQSGIGGFLL 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 641 KPFDEREDPSLSanaIAGKLMHKFSHIPDGFIGIFPPPPVPGLGAtgGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTPE 720
Cdd:PRK09579 612 KPWNERERTQME---LLPLVQAKLEEIPGLQIFGFNLPSLPGTGE--GLPFQFVINTANDYESLLQVAQRVKQRAQESGK 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 721 LANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIGLLKVR 800
Cdd:PRK09579 687 FAFLDIDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVK 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 801 NAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPApgFSSGQATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGN 880
Cdd:PRK09579 767 NEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAIISGFPI--VSMGEAIETVQQIAREEAPEGFAFDYAGASRQYVQEGS 844
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 881 SALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFARA 960
Cdd:PRK09579 845 ALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQ 924
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 961 KEHD-GADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:PRK09579 925 LRHEqGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAK 1004
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
2-1047 |
6.18e-133 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 428.29 E-value: 6.18e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 2 KFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMN 81
Cdd:COG3696 4 RIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 82 TQmAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQ-RIGVVTektSP--DMLMVVhLVSPQKRYDSLYLSN 158
Cdd:COG3696 84 SI-SRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTpELGPIS---TGlgEIYQYT-LESDPGKYSLMELRT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 159 FAIRQVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEasaafQMTVNT 238
Cdd:COG3696 159 LQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQ-----EYLVRG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 239 LGRLTSEEQFGEIVVKIgADGEVTRLRDVARVTLGADaytLRS---LLNGEA-APALQIIQSPGANAIDVSNAIRGKMDE 314
Cdd:COG3696 234 IGLIRSLEDIENIVVKT-RNGTPVLLRDVAEVRIGPA---PRRgaaTLNGEGeVVGGIVLMLKGENALEVIEAVKAKLAE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 315 LQQNFPQDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNT 394
Cdd:COG3696 310 LKPSLPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 395 LSLFGLVLSIGIVVDDAIVVVENVERHISQ------GKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFY 468
Cdd:COG3696 390 MSLGGLAIDFGIIVDGAVVMVENILRRLEEnraagtPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLF 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 469 RQFALTIAISTILSAINSLTLSPALAAILLRPHHDtakadwltrlmgtvtggffHRFNRFFDSASNRYVSAVRRAVRGSV 548
Cdd:COG3696 470 RPMALTVIFALLGALLLSLTLVPVLASLLLRGKVP-------------------EKENPLVRWLKRLYRPLLRWALRHPK 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 549 IVMVLYAGFVGLTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVV----------- 617
Cdd:COG3696 531 LVLAVALVLLVLALALFPRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVsrtgraedatd 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 618 VFPglsvngpvnvPNSALMFAMLKPFDEREDPsLSANAIAGKLMHKFSHIPdgfigifppppvpglGATGGFKLQIEDR- 696
Cdd:COG3696 611 PMG----------VNMSETFVILKPRSEWRSG-RTKEELIAEMREALEQIP---------------GVNFNFSQPIQMRv 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 697 --------AELG-------FEAMTKVQSEIMSKAMQTPELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQI- 760
Cdd:COG3696 665 dellsgvrADVAvkifgddLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETa 744
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 761 ----NLGSLYVNDfnrfgRTWRVMAQADAPFRMQQEDIGLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFP----S 832
Cdd:COG3696 745 iggkAVGQVYEGE-----RRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRrivvQ 819
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 833 VDISGGPAPGFssgqATDAIEKIVRE-TLPEGMVFEWTDlVYQEKQAGNSALAIF-ALAVLLAFLILAAQYNSWSLPFAV 910
Cdd:COG3696 820 ANVRGRDLGSF----VAEAQAKVAEQvKLPPGYYIEWGG-QFENLQRATARLAIVvPLALLLIFLLLYLAFGSVRDALLI 894
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 911 LLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFARAKEHDGADPLTAVLEASRLRLRPILMTSFAF 990
Cdd:COG3696 895 LLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIEGALERLRPVLMTALVA 974
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*..
gi 446595807 991 IAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRRMALKRENR 1047
Cdd:COG3696 975 ALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYLLFGRRRLRRAAA 1031
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
7-1055 |
2.27e-128 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 416.44 E-value: 2.27e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 7 FIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTQMAi 86
Cdd:PRK10503 16 FILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSS- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 87 DGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQRIGVVTEKTSPD----MLMVVHLVSPQKRYDSLYLSNFAIR 162
Cdd:PRK10503 95 GGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADppimTLAVTSTAMPMTQVEDMVETRVAQK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 163 qvrdeLARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVgQQPEASaafqMTVNTLGRL 242
Cdd:PRK10503 175 -----ISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSL-DGPTRA----VTLSANDQM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 243 TSEEQFGEIVVKIgADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQNFPQD 322
Cdd:PRK10503 245 QSAEEYRQLIIAY-QNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKS 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 323 IEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVL 402
Cdd:PRK10503 324 VKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTI 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 403 SIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTILS 482
Cdd:PRK10503 404 ATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILIS 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 483 AINSLTLSPALAAILLRpHHDTAKADWLTRLMGtvtggffhrfnRFFDSASNRYVSAVRRAVRGSVIVMVLYAGFVGLTW 562
Cdd:PRK10503 484 AVVSLTLTPMMCARMLS-QESLRKQNRFSRASE-----------RMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTV 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 563 LGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGlsVNGPVNVPNSALMFAMLKP 642
Cdd:PRK10503 552 LLWIFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVG--VDGTNPSLNSARLQINLKP 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 643 FDEREDpslSANAIAGKLMHKFSHIPDGFIGIfppPPVPGLG-------ATGGFKLQiedraELGFEAMTKVQSEIMSKA 715
Cdd:PRK10503 630 LDERDD---RVQKVIARLQTAVAKVPGVDLYL---QPTQDLTidtqvsrTQYQFTLQ-----ATSLDALSTWVPKLMEKL 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 716 MQTPELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQEDIG 795
Cdd:PRK10503 699 QQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALD 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 796 LLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVRE-TLPEGMV--FEWTDLV 872
Cdd:PRK10503 779 TIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTlNLPADITtqFQGSTLA 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 873 YQEkqAGNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAI 952
Cdd:PRK10503 859 FQS--ALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAI 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 953 LIVEFARAKEHD-GADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGLLLTP 1031
Cdd:PRK10503 937 MMIDFALAAEREqGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTP 1016
|
1050 1060
....*....|....*....|....
gi 446595807 1032 VFYVVVRRMALKRENRVDSHDQQA 1055
Cdd:PRK10503 1017 VIYLLFDRLALYTKSRFPRHEEEA 1040
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
1-1047 |
2.84e-128 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 415.66 E-value: 2.84e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQV---INGVDGM 77
Cdd:PRK10614 1 MKFFALFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSlgrIAGVNEM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 78 lymnTQMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEV-QRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYl 156
Cdd:PRK10614 81 ----TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDTYSQGQLY- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 157 sNFAIRQVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVgqqpeASAAFQMTV 236
Cdd:PRK10614 156 -DFASTQLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAV-----EDGTHRWQI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 237 NTLGRLTSEEQFGEIVVKIGADGEVtRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQ 316
Cdd:PRK10614 230 QTNDELKTAAEYQPLIIHYNNGAAV-RLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 317 QNFPQDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLS 396
Cdd:PRK10614 309 ETIPAAIDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLS 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 397 LFGLVLSIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIA 476
Cdd:PRK10614 389 LMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 477 ISTILSAINSLTLSPALAAILLRPHHDTAKadwlTRLMGtvtggffhrFNRFFDSASNRYVSAVRRAVRGSVIVMVLYAG 556
Cdd:PRK10614 469 VAIGISLLVSLTLTPMMCAWLLKSSKPREQ----KRLRG---------FGRMLVALQQGYGRSLKWVLNHTRWVGVVLLG 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 557 FVGLT-WLgFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPGLSVNgpvnvpNSAL 635
Cdd:PRK10614 536 TIALNvWL-YISIPKTFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRV------NSGM 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 636 MFAMLKPFDEREDpslSANAIAGKLMHKFSHIPDGFIGIFPPPP--VPGLGATGG--FKLQIEDRAELgfeamTKVQSEI 711
Cdd:PRK10614 609 MFITLKPLSERSE---TAQQVIDRLRVKLAKEPGANLFLMAVQDirVGGRQSNASyqYTLLSDDLAAL-----REWEPKI 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 712 MSKAMQTPELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRTWRVMAQADAPFRMQQ 791
Cdd:PRK10614 681 RKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDI 760
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 792 EDIGLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGPAPGFSSGQATDAIEKIVRETLPEGMV---FEW 868
Cdd:PRK10614 761 SALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVrgsFAG 840
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 869 TDLVYQEKQagNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAA 948
Cdd:PRK10614 841 TAQVFQETM--NSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVK 918
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 949 KNAILIVEFA-RAKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGMLGVTLFGL 1027
Cdd:PRK10614 919 KNAIMMVDFAlEAQRNGNLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTL 998
|
1050 1060
....*....|....*....|
gi 446595807 1028 LLTPVFYVVVRRMALKRENR 1047
Cdd:PRK10614 999 YTTPVVYLFFDRLRLRFSRK 1018
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
6-1053 |
2.08e-84 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 295.90 E-value: 2.08e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 6 FFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIADTVAAPLEQVINGVDGMLYMNTqMA 85
Cdd:TIGR00914 8 FSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRS-LS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 86 IDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRLPEEVQR--------IGVVTEKTSPDMLMVVhlVSPQKRYDSLYLS 157
Cdd:TIGR00914 87 RYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPemgpistgLGEIFLYTVEAEEGAR--KKDGGAYTLTDLR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 158 NFAIRQVRDELARLPGVGDVLVWGAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEasaafQMTVN 237
Cdd:TIGR00914 165 TIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGE-----QYLVR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 238 TLGRLTSEEQFGEIVVKIGaDGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGANAIDVSNAIRGKMDELQQ 317
Cdd:TIGR00914 240 APGQVQSMDDIRNIVIATG-EGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 318 NFPQDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSL 397
Cdd:TIGR00914 319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 398 FGLvlSIGIVVDDAIVVVENVERHISQG----------KSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEF 467
Cdd:TIGR00914 399 GAL--DFGLIVDGAVVIVENAHRRLAEAqhhhgrqltlKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKM 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 468 YRQFALTIAISTILSAINSLTLSPALAAILLRpHHDTAKADWLTRLmgtvtggffhrfnrffdsASNRYVSAVRRAVRGS 547
Cdd:TIGR00914 477 FHPMAFTVVLALAGAMILSLTFVPAAVALFIR-GKVAEKENRLMRV------------------LKRRYEPLLERVLAWP 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 548 VIVMVLYAGFVGLTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAVVKQMSAIALAEPGVESVVVFPG-LSVNG 626
Cdd:TIGR00914 538 AVVLGAAAVSIVLVVWIASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGtAEIAT 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 627 PVNVPNSALMFAMLKPFDEREDPSLSANAIAGKLMHKFSHIPdGFIGIFPPPP-------VPGLGATGGFKLQIEDRAEL 699
Cdd:TIGR00914 618 DPMPPNASDTYIILKPESQWPEGKKTKEDLIEEIQEATVRIP-GNNYEFTQPIqmrfnelISGVRSDVAVKVFGDDLDDL 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 700 GFEAmtkvqSEIMSKAMQTPELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDF----NRFGR 775
Cdd:TIGR00914 697 DATA-----EKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETfegdRRFDI 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 776 TWRV-MAQADAPFRMQQEDIGLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDIS---GGPAPGFSSGQATDA 851
Cdd:TIGR00914 772 VIRLpESLRESPQALRQLPIPLPLSEDARKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSanvRGRDLGSFVDDAKKA 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 852 IEKIVRetLPEGMVFEWTDlVYQEKQAGNSALAIFA-LAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGG 930
Cdd:TIGR00914 852 IAEQVK--LPPGYWITWGG-QFEQLQSATKRLQIVVpVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGI 928
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 931 DNNIFTQIGFVVLVGLAAKNAILIVEFARAKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHA 1010
Cdd:TIGR00914 929 PLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRP 1008
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|...
gi 446595807 1011 MGIAVFAGMLGVTLFGLLLTPVFYvvvrRMALKRENRVDSHDQ 1053
Cdd:TIGR00914 1009 LATVVIGGIITATLLTLFVLPALY----RLVHRRRHKGRKEHE 1047
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
363-1045 |
1.68e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 74.90 E-value: 1.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 363 TWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLS--LFGLVLSIGivvddaivvvenV----------ERHISQGKSPGE 430
Cdd:COG1033 241 SLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIG------------IdygihllnryREERRKGLDKRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 431 AAKKAMDEVTGPILsITSVLTAVfipsAFLAGLQGEF--YRQFALTIAISTILSAINSLTLSPALAAILLRPHHDTAKAD 508
Cdd:COG1033 309 ALREALRKLGPPVL-LTSLTTAI----GFLSLLFSDIppIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLK 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 509 WLTRLmgtvtGGFFHRFNRFfdsasnryVSAVRRAVRGSVIVMVLyAGFVGLTWLGFHQVPNGFVPAQDKYYLVgiaqlp 588
Cdd:COG1033 384 KPPEL-----GRLLAKLARF--------VLRRPKVILVVALVLAV-VSLYGISRLKVEYDFEDYLPEDSPIRQD------ 443
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 589 sgasldrTEAVVKQMSaialaepGVESVVVfpglsvngpvnvpnsalmfamlkpfderedpslsanaiagklmhkfship 668
Cdd:COG1033 444 -------LDFIEENFG-------GSDPLEV-------------------------------------------------- 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 669 dgfigIFPPPPvpglgatggfklqiedraelgfeamtkvqseimSKAMQTPELANMLASFQTNAPQLQvDIDRVkaksmg 748
Cdd:COG1033 460 -----VVDTGE---------------------------------PDGLKDPEVLKEIDRLQDYLESLP-EVGKV------ 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 749 VSLTDIFETLQINLGSlYVNDFNRFGRTWRVMAQADAPFRMQQEDIgLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIhyn 828
Cdd:COG1033 495 LSLADLVKELNQALNE-GDPKYYALPESRELLAQLLLLLSSPPGDD-LSRFVDEDYSAARVTVRLKDLDSEEIKALV--- 569
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 829 gfpsvdisggpapgfssgqatDAIEKIVRETLP-EGMVFEWTDLVYQEkQAGNSALA-----IFALAVLLAFLILAAQYN 902
Cdd:COG1033 570 ---------------------EEVRAFLAENFPpDGVEVTLTGSAVLF-AAINESVIesqirSLLLALLLIFLLLLLAFR 627
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 903 SWSLpfAVLLIAPMsLLSAIV--GVW-VSGGDNNIFTQIGFVVLVGLAAKNAILIVE-FARAKEHdGADPLTAVLEASRL 978
Cdd:COG1033 628 SLRL--GLISLIPN-LLPILLtfGLMgLLGIPLNIATAVVASIALGIGVDYTIHFLSrYREERRK-GGDLEEAIRRALRT 703
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446595807 979 RLRPILMTSFAFIAGVVPLVLATGAG-AEMRHAMGIAVFAGMLGVtlfgLLLTPVFYVVVRRMALKRE 1045
Cdd:COG1033 704 TGKAILFTSLTLAAGFGVLLFSSFPPlADFGLLLALGLLVALLAA----LLLLPALLLLLDPRIAKKR 767
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
845-1047 |
1.78e-08 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 58.72 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 845 SGQATDAIEKIVRETLPE-------GMVFEWTDLVyqeKQAGNSALAIFALAVLLAFLILAAQYNSWSLPFAVLLIAPMS 917
Cdd:COG1033 179 RKEVVAEIRAIIAKYEDPgvevyltGFPVLRGDIA---EAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLA 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 918 LLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAI-LIVEFARAKEHdGADPLTAVLEASRLRLRPILMTSFAFIAGVvp 996
Cdd:COG1033 256 VIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIhLLNRYREERRK-GLDKREALREALRKLGPPVLLTSLTTAIGF-- 332
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446595807 997 LVLATgAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRRMALKRENR 1047
Cdd:COG1033 333 LSLLF-SDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRL 382
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
280-494 |
7.33e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 56.77 E-value: 7.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 280 RSLLNGEAAPALQIIQSPGAN----AIDVSNAIRGKMDElqQNFPQDIEYRIAYDPTV---FVRASLQSVAITLLEALVL 352
Cdd:TIGR00921 128 EMFLSKDHTVAIIIVQLKSDAdykqVVPIYNDVERSLER--TNPPSGKFLDVTGSPAInydIEREFGKDMGTTMAISGIL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 353 VVLVVVLFLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVERHISQGKSPGEAA 432
Cdd:TIGR00921 206 VVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAI 285
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446595807 433 KKAMDEvTGPILSITSVLTAVFIPSAFLAGLQgeFYRQFALTIAISTILSAINSLTLSPALA 494
Cdd:TIGR00921 286 VTAVRR-TGRAVLIALLTTSAGFAALALSEFP--MVSEFGLGLVAGLITAYLLTLLVLPALL 344
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
847-1039 |
1.08e-06 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 52.85 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 847 QATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGNSALAIF----ALAVLLAFLILAAQYNSWSLPFAVLLIAPMSLLSAI 922
Cdd:COG2409 132 EAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLgraeLITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVAL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 923 VGVWVSGG--DNNIFTQiGFVVLVGLAAKN--AILIVefARAKE--HDGADPLTAVLEASRLRLRPILMTSFAFIAGVVP 996
Cdd:COG2409 212 GLLALLAAftDVSSFAP-NLLTMLGLGVGIdyALFLV--SRYREelRAGEDREEAVARAVATAGRAVLFSGLTVAIALLG 288
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 446595807 997 LVLatgAGAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRR 1039
Cdd:COG2409 289 LLL---AGLPFLRSMGPAAAIGVAVAVLAALTLLPALLALLGR 328
|
|
| secD |
TIGR01129 |
protein-export membrane protein SecD; Members of this family are highly variable in length ... |
368-493 |
3.58e-05 |
|
protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273456 [Multi-domain] Cd Length: 397 Bit Score: 47.28 E-value: 3.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 368 IIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPILS-- 445
Cdd:TIGR01129 274 LIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAVDANVLIYERIKEELRLGKSVRQAIEAGFERAFSTIFDan 353
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446595807 446 ITSVLTAVFIpSAFLAG-LQGefyrqFALTIAISTILSAINSLTLSPAL 493
Cdd:TIGR01129 354 ITTLIAALIL-YVFGTGpVKG-----FAVTLAIGIIASLFTALVFTRLL 396
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
833-1047 |
4.74e-05 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 46.90 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 833 VDISGGPAPGFSSGQAT-DAIEKIVRETLP-EGMVFEWTD---LVYQEKQAGNSALA-IFALAVLLAFLILAAQYNSWSL 906
Cdd:pfam03176 89 VVVTLEGDPGTTEADESvAAVRDAVEQAPPpEGLKAYLTGpaaTVADLRDAGDRDLGlIEAVTLVVIFIILLIVYRSVVA 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 907 PFAVLLIAPMSLLSA--IVGVWVSGGDNNIFTQ---IGFVVLVGLAAKNAILIVefARAKE--HDGADPLTAVLEASRLR 979
Cdd:pfam03176 169 ALLPLLTVGLSLGAAqgLVAILAHILGIGLSTFalnLLVVLLIAVGTDYALFLV--SRYREelRAGEDREEAVIRAVRGT 246
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446595807 980 LRPILMTSFAFIAGVVPLVLATgagAEMRHAMGIAVFAGMLGVTLFGLLLTPVFYVVVRRMALKRENR 1047
Cdd:pfam03176 247 GKVVTAAGLTVAIAMLALSFAR---LPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPKR 311
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
364-497 |
4.26e-04 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 44.49 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 364 WRASIIPLVaVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDaivvveNVerHISQG--KSPGEAAKK---AMDE 438
Cdd:TIGR00918 990 WTAGLIVLV-LALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEF------TV--HIALGflTAIGDRNRRavlALEH 1060
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446595807 439 VTGPIL-SITSVLTAVFIpsafLAGLQGEF-YRQFALTIAISTILSAINSLTLSPALAAIL 497
Cdd:TIGR00918 1061 MFAPVLdGALSTLLGVLM----LAGSEFDFiVRYFFAVLAVLTCLGVLNGLVLLPVLLSMF 1117
|
|
| PRK14726 |
PRK14726 |
protein translocase subunit SecDF; |
368-560 |
8.93e-04 |
|
protein translocase subunit SecDF;
Pssm-ID: 237805 [Multi-domain] Cd Length: 855 Bit Score: 43.56 E-value: 8.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 368 IIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVERHISQGKSPGEAAKKAMDEVTGPIlsIT 447
Cdd:PRK14726 398 VIAVIALIVNVVLIIAVLSLLGATLTLPGIAGIVLTIGMAVDSNVLIYERIREEEKTGHSLIQALDRGFSRALATI--VD 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595807 448 SVLTaVFIPSAFLAGLQGEFYRQFALTIAISTILSAINSLTLSPALAAILLR---PHHdtakadwLTRlmGTVTGGFFHR 524
Cdd:PRK14726 476 ANVT-ILIAAVILFFLGSGAVRGFAVTLAVGILTTVFTAFTLTRSLVAVWLRrrrPKH-------LPK--GVRTGLFEGA 545
|
170 180 190
....*....|....*....|....*....|....*.
gi 446595807 525 FNRFFdsASNRYVSAVRRAVrgSVIVMVLYAGfVGL 560
Cdd:PRK14726 546 NIRFM--GIRRYVFTLSAAL--SLASLVLFAT-VGL 576
|
|
| |
