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Conserved domains on  [gi|446595848|ref|WP_000673194|]
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MULTISPECIES: NAD kinase [Bacillus]

Protein Classification

NAD kinase( domain architecture ID 10012226)

ATP-dependent NAD kinase catalyzes the phosphorylation of NAD to NADP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-265 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


:

Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 531.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   1 MKFTIMSKGDQSSDTLASTMKEYLLDFGFIMDEQEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  81 TEVEKLVIAIAKTPFQVVEYPLLEVIIRYMNGSKESqYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEGTLVADVYINGVLFERFRGDGLCVSTPTGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPTAGMNLQITVDHLTMVHQDVKSIQYRVAN 240
Cdd:PRK04885 160 TAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVAN 239

                        250       260
                 ....*....|....*....|....*
gi 446595848 241 EKVRFVRFRPFPFWKRVRDSFVADK 265
Cdd:PRK04885 240 EKIRFARFRHFPFWKRVKDSFIGEV 264
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-265 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 531.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   1 MKFTIMSKGDQSSDTLASTMKEYLLDFGFIMDEQEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  81 TEVEKLVIAIAKTPFQVVEYPLLEVIIRYMNGSKESqYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEGTLVADVYINGVLFERFRGDGLCVSTPTGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPTAGMNLQITVDHLTMVHQDVKSIQYRVAN 240
Cdd:PRK04885 160 TAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVAN 239

                        250       260
                 ....*....|....*....|....*
gi 446595848 241 EKVRFVRFRPFPFWKRVRDSFVADK 265
Cdd:PRK04885 240 EKIRFARFRHFPFWKRVKDSFIGEV 264
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
5-261 7.36e-82

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 246.97  E-value: 7.36e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   5 IMSKGDQSSDTLASTMKEYLLDFGF--IMDE-------------QEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHT 69
Cdd:COG0061    7 VAKPGKPEALEAAEELAELLEERGIevVLDEdtavpgvpleelgEEADLVIVLGGDGTLLRAARLLAPL--GIPILGINL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  70 GHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIrYMNGSKESQYLAMNEATVKSA--EGTLVTEVEIRGEYFETF 147
Cdd:COG0061   85 GRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATV-DRDGEVVHEALALNEVVVLRGsiARMIELEVYIDGEFLEEF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 148 RGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVfrtvgSPLVLPKHHTCVLKPTAGM-NLQITVDH-LT 225
Cdd:COG0061  164 RGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHTLSS-----RPLVLPDDSEIEIEVLEDSrPAVLVADGqEV 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446595848 226 MVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSF 261
Cdd:COG0061  239 RDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKL 274
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-184 9.22e-12

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 60.78  E-value: 9.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446595848  121 MNEATVKSAEGTLV--TEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:pfam20143   1 LNEVVYVRGPGATMieFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPI 66
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-265 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 531.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   1 MKFTIMSKGDQSSDTLASTMKEYLLDFGFIMDEQEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  81 TEVEKLVIAIAKTPFQVVEYPLLEVIIRYMNGSKESqYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEGTLVADVYINGVLFERFRGDGLCVSTPTGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPTAGMNLQITVDHLTMVHQDVKSIQYRVAN 240
Cdd:PRK04885 160 TAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVAN 239

                        250       260
                 ....*....|....*....|....*
gi 446595848 241 EKVRFVRFRPFPFWKRVRDSFVADK 265
Cdd:PRK04885 240 EKIRFARFRHFPFWKRVKDSFIGEV 264
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
5-261 7.36e-82

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 246.97  E-value: 7.36e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   5 IMSKGDQSSDTLASTMKEYLLDFGF--IMDE-------------QEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHT 69
Cdd:COG0061    7 VAKPGKPEALEAAEELAELLEERGIevVLDEdtavpgvpleelgEEADLVIVLGGDGTLLRAARLLAPL--GIPILGINL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  70 GHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIrYMNGSKESQYLAMNEATVKSA--EGTLVTEVEIRGEYFETF 147
Cdd:COG0061   85 GRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATV-DRDGEVVHEALALNEVVVLRGsiARMIELEVYIDGEFLEEF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 148 RGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVfrtvgSPLVLPKHHTCVLKPTAGM-NLQITVDH-LT 225
Cdd:COG0061  164 RGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHTLSS-----RPLVLPDDSEIEIEVLEDSrPAVLVADGqEV 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446595848 226 MVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSF 261
Cdd:COG0061  239 RDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKL 274
ppnK PRK03501
NAD kinase;
7-261 7.19e-57

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 182.87  E-value: 7.19e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   7 SKGDQSSDTLASTMKEYLLDFGFIM--DEQEPDIVISVGGDGTLLYAFhRYYNRLDETAFVGVHT-GHLGFYADWLPTEV 83
Cdd:PRK03501   9 YKRDKELVEKVKPLKKIAEEYGFTVvdHPKNANIIVSIGGDGTFLQAV-RKTGFREDCLYAGISTkDQLGFYCDFHIDDL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  84 EKLVIAIAKTPFQVVEYPLLEVIIrymNGSKesQYLAMNEATVKSAE-GTLVTEVEIRGEYFETFRGDGLCISTPSGSTA 162
Cdd:PRK03501  88 DKMIQAITKEEIEVRKYPTIEVTV---DGST--SFYCLNEFSIRSSIiKTFVIDVYIDDLHFETFRGDGMVVSTPTGSTA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 163 YNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLK--------PTAGMnlqitvDHLTMVHQDVKSI 234
Cdd:PRK03501 163 YNKSVRGAVVDPLIPCFQVSELASLNNNTYRTLGSPFILSHERKLTLKivqdgndyPIIGM------DNEALSIKHVEKI 236

                        250       260
                 ....*....|....*....|....*..
gi 446595848 235 QYRVANEKVRFVRFRPFPFWKRVRDSF 261
Cdd:PRK03501 237 DIRLSDKQIKTVKLKDNSFWEKVKRTF 263
pnk PRK14077
NAD(+) kinase;
28-247 2.04e-30

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 114.88  E-value: 2.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  28 GFIMDE--QEPDIVISVGGDGTLLYAFHRYYNrldETAFV-GVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLE 104
Cdd:PRK14077  55 GYGLDElfKISDFLISLGGDGTLISLCRKAAE---YDKFVlGIHAGHLGFLTDITVDEAEKFFQAFFQGEFEIEKPYMLS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 105 VIIRYMNGsKESQYLAMNEATVKSAEGTLVTEVE--IRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIA 182
Cdd:PRK14077 132 VFLEKKQG-KILEKLAFNDVVISKNNQASMAHIEafLNEKYFNEYFGDGVIVATPAGSTAYNMSANGPIIYPLSQVFILT 210

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446595848 183 EMA--SINNRvfrtvgsPLVLPKHHTCVLKPTAGMNLQIT-VDHLTMvhQDVKSIQYRVANEKVRFVR 247
Cdd:PRK14077 211 PVCshSLTQR-------PIVLPKGFEVEFKTKSDCILCIDgQDRYKM--NDFKSIKVGLSDKNVALIR 269
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 29-258 1.03e-29

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 113.10  E-value: 1.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  29 FIMDEQEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIR 108
Cdd:PRK01911  58 NEELDGSADMVISIGGDGTFLRTATYVGNS--NIPILGINTGRLGFLATVSKEEIEETIDELLNGDYTIEERSLLQLESN 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 109 YMNGsKESQYlAMNEATVKSAEGTLVTEVE--IRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA- 185
Cdd:PRK01911 136 PKLF-GELNF-ALNEIAILKRDTSSMITVHtyLNGEYLNSYWADGLIVATPTGSTGYSLSCGGPIIVPDAKSFVITPIAp 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446595848 186 -SINNRvfrtvgsPLVLPKHHTCVLKPTA-GMNLQITVDHLTMVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVR 258
Cdd:PRK01911 214 hNLNVR-------PLVIPDDTEITLEVESrSDNFLVSLDSRSETVDNGTELTIKKADFTIKLVELNNHSFLKTLR 281
ppnK PRK01185
NAD(+) kinase;
28-264 2.98e-27

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 106.05  E-value: 2.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  28 GFIMDEQEPDIVISVGGDGTLLYAFHRYYNRLdetafVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVii 107
Cdd:PRK01185  45 GLDIEEINADVIITIGGDGTILRTLQRAKGPI-----LGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDERMKLKV-- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 108 rYMNGskESQYLAMNEATVKSAEGTLVTEVEI--RGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA 185
Cdd:PRK01185 118 -YING--ERLEDCTNEAVIHTDRIAKIRQFKIyyDGHFLDTFKADGVIVATPTGSTSYSSSAGGPILLPNLEGMVISYIA 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 186 SINNRVfrtvgSPLVLPKHHTCVLKPTAGMNLQITVD---HLTMVHQDVKSIqyRVANEKVRFVRFRPFPFwKRVRDSFV 262
Cdd:PRK01185 195 PYSSRP-----KSVVVPSESTVEIKIAGDQSSLLILDgqyEYKISKGDTVEI--SKSENYARFISFRESPY-DRIREKLI 266


                 ..
gi 446595848 263 AD 264
Cdd:PRK01185 267 KH 268
ppnK PRK00561
NAD(+) kinase;
1-203 1.02e-24

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 99.18  E-value: 1.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   1 MKFTIMSKGDQSSDTLASTMKEYLLdfGFIMDEQEPDIVISVGGDGTLLYAFHRYyNRlDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK00561   1 MKYKIFASTTPQTEPVLPKLKKVLK--KKLAVEDGADYLFVLGGDGFFVSTAANY-NC-AGCKVVGINTGHLGFYTSFNE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  81 TEVEKlVIAIAKTPFQVVEYPLLEVIIrymngsKESQYLAMNEATVKSAEGTLVtEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK00561  77 TDLDQ-NFANKLDQLKFTQIDLLEVQI------DDQIHLVLNELAVYTNTAYPI-NIFIDNEFWEKYRGSGLLIGPRTGS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446595848 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPK 203
Cdd:PRK00561 149 TALAKSAKGAVIFPRIDVIQIIELNPLLHPNQTTIQSPIILPI 191
ppnK PRK01231
NAD(+) kinase;
37-184 6.77e-24

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 97.72  E-value: 6.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  37 DIVISVGGDGTLLYAFH---RYynrldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRyMNGS 113
Cdd:PRK01231  64 DLVIVVGGDGSLLGAARalaRH-----NVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEAEVR-RGGE 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446595848 114 KESQYLAMNEATVKSAEGTLVTEVE--IRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:PRK01231 138 VIGQGDALNDVVLHPGKSTRMIEFElyIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPIMHPKLDAIVLVPM 210
ppnK PRK02645
NAD(+) kinase;
33-219 4.49e-23

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 95.36  E-value: 4.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  33 EQEPDIVISVGGDGTLLYAfHRYYNRLDET--AF-VGvhtGHLGFYADwlPTEV---EKLVIAIAKTPFQVVEYPLLEVI 106
Cdd:PRK02645  55 SELIDLAIVLGGDGTVLAA-ARHLAPHDIPilSVnVG---GHLGFLTH--PRDLlqdESVWDRLQEDRYAIERRMMLQAR 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 107 I----RYMNGSKESQYLAMNEATVKSAEG----TLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEA 178
Cdd:PRK02645 129 VfegdRSNEEPVSESYYALNDFYLKPASEdrspTCILELEIDGEVVDQYQGDGLIVSTPTGSTAYTMAAGGPILHPGIDA 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446595848 179 IQIAEMA--SINNRvfrtvgsPLVLPKHHTCVLKPTAGMNLQI 219
Cdd:PRK02645 209 IIVTPICpmSLSSR-------PIVIPPGSRVVIWPLGDYDLNI 244
ppnK PRK02155
NAD kinase;
37-246 1.53e-21

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 91.16  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  37 DIVISVGGDGTLL---YAFHRYynrldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEV-IIRymNG 112
Cdd:PRK02155  65 DLAVVLGGDGTMLgigRQLAPY-----GVPLIGINHGRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLEArVVR--DG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 113 SKESQYLAMNEATV-KSAEGTLVT-EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA--SIN 188
Cdd:PRK02155 138 EPIFHALAFNDVVVnRSGFSGMVElRVSVDGRFMYNQRSDGLIVATPTGSTAYALSAGGPILHPQLPGWVLVPIAphTLS 217

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446595848 189 NRvfrtvgsPLVLPKHHTCVLKPTAGMNLQITVD---HLTMVHQDvkSIQYRVANEKVRFV 246
Cdd:PRK02155 218 NR-------PIVLPDDSEVAIQIVGGRDVSVNFDmqsLTSLELGD--RIEVRRSPHTVRFL 269
pnk PRK14075
NAD(+) kinase;
1-185 3.27e-21

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 89.40  E-value: 3.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   1 MKFTIMSKGDQSSDtlASTMKEYLLDFGFIMD----EQEP----DIVISVGGDGTLLYAFHRYYNRLdetafVGVHTGHL 72
Cdd:PRK14075   1 MKLGIFYREEKEKE--AKFLKEKISKEHEVVEfceaSASGkvtaDLIIVVGGDGTVLKAAKKVGTPL-----VGFKAGRL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  73 GFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEViirymnGSKESQYLAMNEAT-VKSAEGTLV---TEVEIRGEYFetFR 148
Cdd:PRK14075  74 GFLSSYTLEEIDRFLEDLKNWNFREEKRWFLKI------ESELGNHLALNDVTlERDPSQKMVeieVSFEDHSSMW--FF 145

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446595848 149 GDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA 185
Cdd:PRK14075 146 ADGVVISTPTGSTAYSLSLGGPIILPNCEVFEITPIA 182
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-190 1.56e-19

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 85.68  E-value: 1.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  37 DIVISVGGDGTLLYAFHRYYNRldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLE-VIIRymNGSKE 115
Cdd:PRK04539  70 DLVAVLGGDGTFLSVAREIAPR--AVPIIGINQGHLGFLTQIPREYMTDKLLPVLEGKYLAEERILIEaALIR--EGKTA 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446595848 116 SQYLAMNEATV-KSAEGTLVT-EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA--SINNR 190
Cdd:PRK04539 146 ERALALNDAVLsRGGAGQMIEfEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGLHAFTLVPICpqSMTNR 224
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
14-181 2.52e-18

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 84.01  E-value: 2.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  14 DTLASTMKEYLLDFGFIMDE-QEPDIVISVGGDGTLLYAfHRYYNRlDETAFVGVHTGHLGFYADWLPTEVEKLVIAIAK 92
Cdd:PRK14076 326 SFLYNKLKNRLNEECNLIDDiEEISHIISIGGDGTVLRA-SKLVNG-EEIPIICINMGTVGFLTEFSKEEIFKAIDSIIS 403

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  93 TPFQVVEYPLLEVIIRYMNGSKESqYLAMNEATV--KSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGA 170
Cdd:PRK14076 404 GEYEIEKRTKLSGFILKDGHQNIL-PSALNEVVIttKNPAKMLHFEVYVNGELVEEVRADGIIISTPTGSTAYSLSAGGP 482

                        170
                 ....*....|.
gi 446595848 171 IIHPSIEAIQI 181
Cdd:PRK14076 483 IVEPTVDGFII 493
ppnK PRK02231
NAD(+) kinase;
34-184 2.06e-17

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 79.46  E-value: 2.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  34 QEPDIVISVGGDGTLLyAFHRYYNRLDeTAFVGVHTGHLGFYADWLP-TEVEKLVIAIAKTPFQVVEYPLLEVIIRyMNG 112
Cdd:PRK02231  41 QRAQLAIVIGGDGNML-GRARVLAKYD-IPLIGINRGNLGFLTDIDPkNAYEQLEACLERGEFFVEERFLLEAKIE-RNG 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446595848 113 SKESQYLAMNEATVKSAE--GTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:PRK02231 118 KIIATSNALNEVVIHPAKiaHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAIALVPM 191
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 24-184 4.34e-17

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 78.83  E-value: 4.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  24 LLDFGfimdeQEPDIVISVGGDGTLLYAfHRYYNRLDeTAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLL 103
Cdd:PRK03378  57 LAEIG-----QQADLAIVVGGDGNMLGA-ARVLARYD-IKVIGINRGNLGFLTDLDPDNALQQLSDVLEGHYISEKRFLL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 104 EVIIrYMNGSKESQYLAMNEATVKSaeGTLVT----EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAI 179
Cdd:PRK03378 130 EAQV-CRHGQQKRISTAINEVVLHP--GKVAHmiefEVYIDDNFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAI 206


                 ....*
gi 446595848 180 QIAEM 184
Cdd:PRK03378 207 TLVPM 211
ppnK PRK03708
NAD(+) kinase;
1-248 5.61e-17

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 78.21  E-value: 5.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848   1 MKFTIMSKGD-QSSDTLASTMKEYLLDFGF--IMDEQ-------------------EPDIVISVGGDGTLLYAFHryyNR 58
Cdd:PRK03708   1 MRFGIVARRDkEEALKLAYRVYDFLKVSGYevVVDSEtyehlpefseedvlpleemDVDFIIAIGGDGTILRIEH---KT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  59 LDETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEViirYMNGskESQYLAMNE-ATVKSAEGTLV-TE 136
Cdd:PRK03708  78 KKDIPILGINMGTLGFLTEVEPEETFFALSRLLEGDYFIDERIKLRV---YING--ENVPDALNEvVILTGIPGKIIhLK 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 137 VEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASinnrvFRTVGSPLVLPKHHTCVLKPTA-GM 215
Cdd:PRK03708 153 YYVDGELADEVRADGLIISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCP-----FKLSSRPMVVPSSSRIDVKLLRtGR 227

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446595848 216 NLQITVD--HLTMVHQDVKsIQYRVANEKVRFVRF 248
Cdd:PRK03708 228 EIILVIDgqYYEELPPDTE-ITIKKSPRKTKFVRF 261
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-181 1.01e-16

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 78.03  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  37 DIVISVGGDGTLLyafhryynRLDETA------FVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRyM 110
Cdd:PRK03372  74 ELVLVLGGDGTIL--------RAAELAraadvpVLGVNLGHVGFLAEAEAEDLDEAVERVVDRDYRVEERMTLDVTVR-V 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446595848 111 NGSKESQYLAMNEATVKSA--EGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQI 181
Cdd:PRK03372 145 GGEIVWRGWALNEASLEKAdrEGMLEVVLEVDGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLV 217
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 20-206 1.13e-16

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 79.11  E-value: 1.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  20 MKEYLL----DFGFIM---DEQEP-------DIVISVGGDGTLLYAFHRYYNRLdeTAFVGVHTGHLGFYADWLPTEVEK 85
Cdd:PLN02935 233 VKKELLsessYFNFVQtweDEKEIlllhtkvDLVITLGGDGTVLWAASMFKGPV--PPVVPFSMGSLGFMTPFHSEQYRD 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  86 LVIAIAKTPFQVVEYPLLEV-IIRYMNGSK---ESQYLAMNEATVKSAEGTLVTEVEI--RGEYFETFRGDGLCISTPSG 159
Cdd:PLN02935 311 CLDAILKGPISITLRHRLQChIIRDAAKNEyetEEPILVLNEVTIDRGISSFLTNLECycDNSFVTCVQGDGLILSTTSG 390

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446595848 160 STAYNKALGGAIIHPSIEAIQIAEMASiNNRVFRtvgsPLVLPKHHT 206
Cdd:PLN02935 391 STAYSLAAGGSMVHPQVPGILFTPICP-HSLSFR----PLILPEYVT 432
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 27-172 7.47e-12

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 63.30  E-value: 7.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  27 FGFImDEQEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHTGHLGF----YADwlptevEKLVIAIAK-TPFQVveYP 101
Cdd:PRK04761  18 YGDV-PIEEADVIVALGGDGFMLQTLHRYMNS--GKPVYGMNRGSVGFlmneYSE------DDLLERIAAaEPTVL--HP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446595848 102 LLeviIRYMNGSKESQ-YLAMNE-----ATVKSAEgtlvTEVEIRG-EYFETFRGDGLCISTPSGSTAYNKALGGAII 172
Cdd:PRK04761  87 LR---MTATDVSGEVHeALAINEvslfrQTRQAAK----LRISIDGkVRMEELVCDGVLVATPAGSTAYNLSAHGPIL 157
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-184 9.22e-12

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 60.78  E-value: 9.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446595848  121 MNEATVKSAEGTLV--TEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:pfam20143   1 LNEVVYVRGPGATMieFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPI 66
ppnK PRK02649
NAD(+) kinase;
40-259 9.93e-11

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 60.76  E-value: 9.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848  40 ISVGGDGTLLYAFHryynrldETAFVG-----VHTGHLGF----YADWLPTEVEKLViaiaKTPFQVVEYPLLEVIIrYM 110
Cdd:PRK02649  73 IVLGGDGTVLSAAR-------QLAPCGiplltINTGHLGFlteaYLNQLDEAIDQVL----AGQYTIEERTMLTVSV-MR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 111 NGSKESQYLAMNEATVKSAEGTLVTEVEIR-GEYFET-FRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA--S 186
Cdd:PRK02649 141 GDQLRWEALSLNEMVLHREPLTSMCHFEIAiGRHAPVdIAADGVILSTPTGSTAYSLSAGGPVITPDVPVLQLTPICphS 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595848 187 INNRVfrtvgspLVLPKHHTCVLKPTagmnlqiTVDHLTMV----------HQDvkSIQYRVANEKVRFVRFRPFPFWKR 256
Cdd:PRK02649 221 LASRA-------LVFSDSEPVTVFPA-------TPERLVMVvdgnagcyvwPED--RVLIRRSPYPVRFIRLQDPEFFRV 284


                 ...
gi 446595848 257 VRD 259
Cdd:PRK02649 285 LRE 287
PLN02727 PLN02727
NAD kinase
 148-176 2.28e-05

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 45.26  E-value: 2.28e-05
                         10        20
                 ....*....|....*....|....*....
gi 446595848 148 RGDGLCISTPSGSTAYNKALGGAIIHPSI 176
Cdd:PLN02727 862 QGDGVIVATPTGSTAYSTAAGGSMVHPNV 890
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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