NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446595850|ref|WP_000673196|]
View 

MULTISPECIES: NAD kinase [Bacillus]

Protein Classification

NAD kinase( domain architecture ID 10012226)

ATP-dependent NAD kinase catalyzes the phosphorylation of NAD to NADP

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-265 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


:

Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 530.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   1 MKFTIMSKGDQSSDTLASTMKEYLLDFGFTMDEKEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  81 TEVEKLVIAIAKTPFQVVEYPLLEVIIRYVNGSKESqYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEGTLVADVYINGVLFERFRGDGLCVSTPTGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPAAGMNLQITVDHLTMVHQDVKSIQYRVAN 240
Cdd:PRK04885 160 TAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVAN 239

                        250       260
                 ....*....|....*....|....*
gi 446595850 241 EKVRFVRFRPFPFWKRVRDSFVADK 265
Cdd:PRK04885 240 EKIRFARFRHFPFWKRVKDSFIGEV 264
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-265 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 530.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   1 MKFTIMSKGDQSSDTLASTMKEYLLDFGFTMDEKEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  81 TEVEKLVIAIAKTPFQVVEYPLLEVIIRYVNGSKESqYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEGTLVADVYINGVLFERFRGDGLCVSTPTGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPAAGMNLQITVDHLTMVHQDVKSIQYRVAN 240
Cdd:PRK04885 160 TAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVAN 239

                        250       260
                 ....*....|....*....|....*
gi 446595850 241 EKVRFVRFRPFPFWKRVRDSFVADK 265
Cdd:PRK04885 240 EKIRFARFRHFPFWKRVKDSFIGEV 264
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
5-261 3.75e-82

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 247.74  E-value: 3.75e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   5 IMSKGDQSSDTLASTMKEYLLDFGFTM---------------DEKEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHT 69
Cdd:COG0061    7 VAKPGKPEALEAAEELAELLEERGIEVvldedtavpgvpleeLGEEADLVIVLGGDGTLLRAARLLAPL--GIPILGINL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  70 GHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIrYVNGSKESQYLAMNEATVKSA--EGTLVTEVEIRGEYFETF 147
Cdd:COG0061   85 GRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATV-DRDGEVVHEALALNEVVVLRGsiARMIELEVYIDGEFLEEF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 148 RGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVfrtvgSPLVLPKHHTCVLKP-AAGMNLQITVDH-LT 225
Cdd:COG0061  164 RGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHTLSS-----RPLVLPDDSEIEIEVlEDSRPAVLVADGqEV 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446595850 226 MVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSF 261
Cdd:COG0061  239 RDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKL 274
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-247 7.53e-12

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 61.16  E-value: 7.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  121 MNEATVKSAEGTLV--TEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRvFRtvgsP 198
Cdd:pfam20143   1 LNEVVYVRGPGATMieFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLS-SR----P 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446595850  199 LVLPKHHTCVLKPAAGMN--LQITVDHLTMV-HQDVKSIqyRVANEKVRFVR 247
Cdd:pfam20143  76 IVVSSSSKLRIRVLSRAEalLVDDGDPELDIsPGDRVRV--RKSYYKAKFIR 125
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-265 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 530.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   1 MKFTIMSKGDQSSDTLASTMKEYLLDFGFTMDEKEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  81 TEVEKLVIAIAKTPFQVVEYPLLEVIIRYVNGSKESqYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEGTLVADVYINGVLFERFRGDGLCVSTPTGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPAAGMNLQITVDHLTMVHQDVKSIQYRVAN 240
Cdd:PRK04885 160 TAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVAN 239

                        250       260
                 ....*....|....*....|....*
gi 446595850 241 EKVRFVRFRPFPFWKRVRDSFVADK 265
Cdd:PRK04885 240 EKIRFARFRHFPFWKRVKDSFIGEV 264
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
5-261 3.75e-82

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 247.74  E-value: 3.75e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   5 IMSKGDQSSDTLASTMKEYLLDFGFTM---------------DEKEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHT 69
Cdd:COG0061    7 VAKPGKPEALEAAEELAELLEERGIEVvldedtavpgvpleeLGEEADLVIVLGGDGTLLRAARLLAPL--GIPILGINL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  70 GHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIrYVNGSKESQYLAMNEATVKSA--EGTLVTEVEIRGEYFETF 147
Cdd:COG0061   85 GRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATV-DRDGEVVHEALALNEVVVLRGsiARMIELEVYIDGEFLEEF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 148 RGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVfrtvgSPLVLPKHHTCVLKP-AAGMNLQITVDH-LT 225
Cdd:COG0061  164 RGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHTLSS-----RPLVLPDDSEIEIEVlEDSRPAVLVADGqEV 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446595850 226 MVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSF 261
Cdd:COG0061  239 RDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKL 274
ppnK PRK03501
NAD kinase;
7-261 1.60e-57

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 184.41  E-value: 1.60e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   7 SKGDQSSDTLASTMKEYLLDFGFTM--DEKEPDIVISVGGDGTLLYAFhRYYNRLDETAFVGVHT-GHLGFYADWLPTEV 83
Cdd:PRK03501   9 YKRDKELVEKVKPLKKIAEEYGFTVvdHPKNANIIVSIGGDGTFLQAV-RKTGFREDCLYAGISTkDQLGFYCDFHIDDL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  84 EKLVIAIAKTPFQVVEYPLLEVIIryvNGSKesQYLAMNEATVKSAE-GTLVTEVEIRGEYFETFRGDGLCISTPSGSTA 162
Cdd:PRK03501  88 DKMIQAITKEEIEVRKYPTIEVTV---DGST--SFYCLNEFSIRSSIiKTFVIDVYIDDLHFETFRGDGMVVSTPTGSTA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 163 YNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLK--------PAAGMnlqitvDHLTMVHQDVKSI 234
Cdd:PRK03501 163 YNKSVRGAVVDPLIPCFQVSELASLNNNTYRTLGSPFILSHERKLTLKivqdgndyPIIGM------DNEALSIKHVEKI 236

                        250       260
                 ....*....|....*....|....*..
gi 446595850 235 QYRVANEKVRFVRFRPFPFWKRVRDSF 261
Cdd:PRK03501 237 DIRLSDKQIKTVKLKDNSFWEKVKRTF 263
pnk PRK14077
NAD(+) kinase;
28-247 1.97e-31

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 117.57  E-value: 1.97e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  28 GFTMDE--KEPDIVISVGGDGTLLYAFHRYYNrldETAFV-GVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLE 104
Cdd:PRK14077  55 GYGLDElfKISDFLISLGGDGTLISLCRKAAE---YDKFVlGIHAGHLGFLTDITVDEAEKFFQAFFQGEFEIEKPYMLS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 105 VIIRYVNGsKESQYLAMNEATVKSAEGTLVTEVE--IRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIA 182
Cdd:PRK14077 132 VFLEKKQG-KILEKLAFNDVVISKNNQASMAHIEafLNEKYFNEYFGDGVIVATPAGSTAYNMSANGPIIYPLSQVFILT 210

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446595850 183 EMA--SINNRvfrtvgsPLVLPKHHTCVLKPAAGMNLQIT-VDHLTMvhQDVKSIQYRVANEKVRFVR 247
Cdd:PRK14077 211 PVCshSLTQR-------PIVLPKGFEVEFKTKSDCILCIDgQDRYKM--NDFKSIKVGLSDKNVALIR 269
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 29-258 1.10e-29

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 113.10  E-value: 1.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  29 FTMDEKEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIR 108
Cdd:PRK01911  58 NEELDGSADMVISIGGDGTFLRTATYVGNS--NIPILGINTGRLGFLATVSKEEIEETIDELLNGDYTIEERSLLQLESN 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 109 YVNGsKESQYlAMNEATVKSAEGTLVTEVE--IRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA- 185
Cdd:PRK01911 136 PKLF-GELNF-ALNEIAILKRDTSSMITVHtyLNGEYLNSYWADGLIVATPTGSTGYSLSCGGPIIVPDAKSFVITPIAp 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446595850 186 -SINNRvfrtvgsPLVLPKHHTCVLK-PAAGMNLQITVDHLTMVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVR 258
Cdd:PRK01911 214 hNLNVR-------PLVIPDDTEITLEvESRSDNFLVSLDSRSETVDNGTELTIKKADFTIKLVELNNHSFLKTLR 281
ppnK PRK01185
NAD(+) kinase;
28-264 1.41e-28

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 109.52  E-value: 1.41e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  28 GFTMDEKEPDIVISVGGDGTLLYAFHRYYNRLdetafVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVii 107
Cdd:PRK01185  45 GLDIEEINADVIITIGGDGTILRTLQRAKGPI-----LGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDERMKLKV-- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 108 rYVNGskESQYLAMNEATVKSAEGTLVTEVEI--RGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA 185
Cdd:PRK01185 118 -YING--ERLEDCTNEAVIHTDRIAKIRQFKIyyDGHFLDTFKADGVIVATPTGSTSYSSSAGGPILLPNLEGMVISYIA 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 186 SINNRVfrtvgSPLVLPKHHTCVLKPAAGMNLQITVD---HLTMVHQDVKSIqyRVANEKVRFVRFRPFPFwKRVRDSFV 262
Cdd:PRK01185 195 PYSSRP-----KSVVVPSESTVEIKIAGDQSSLLILDgqyEYKISKGDTVEI--SKSENYARFISFRESPY-DRIREKLI 266


                 ..
gi 446595850 263 AD 264
Cdd:PRK01185 267 KH 268
ppnK PRK00561
NAD(+) kinase;
1-203 4.30e-25

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 99.95  E-value: 4.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   1 MKFTIMSKGDQSSDTLASTMKEYLLdfGFTMDEKEPDIVISVGGDGTLLYAFHRYyNRlDETAFVGVHTGHLGFYADWLP 80
Cdd:PRK00561   1 MKYKIFASTTPQTEPVLPKLKKVLK--KKLAVEDGADYLFVLGGDGFFVSTAANY-NC-AGCKVVGINTGHLGFYTSFNE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  81 TEVEKLVIAiAKTPFQVVEYPLLEVIIryvngsKESQYLAMNEATVKSAEGTLVtEVEIRGEYFETFRGDGLCISTPSGS 160
Cdd:PRK00561  77 TDLDQNFAN-KLDQLKFTQIDLLEVQI------DDQIHLVLNELAVYTNTAYPI-NIFIDNEFWEKYRGSGLLIGPRTGS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446595850 161 TAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPK 203
Cdd:PRK00561 149 TALAKSAKGAVIFPRIDVIQIIELNPLLHPNQTTIQSPIILPI 191
ppnK PRK01231
NAD(+) kinase;
37-184 6.11e-24

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 97.72  E-value: 6.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  37 DIVISVGGDGTLLYAFH---RYynrldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRYvNGS 113
Cdd:PRK01231  64 DLVIVVGGDGSLLGAARalaRH-----NVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEAEVRR-GGE 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446595850 114 KESQYLAMNEATVKSAEGTLVTEVE--IRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:PRK01231 138 VIGQGDALNDVVLHPGKSTRMIEFElyIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPIMHPKLDAIVLVPM 210
ppnK PRK02645
NAD(+) kinase;
36-219 1.66e-22

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 93.82  E-value: 1.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  36 PDIVISVGGDGTLLYAfHRYYNRLDET--AF-VGvhtGHLGFYADwlPTEV---EKLVIAIAKTPFQVVEYPLLEVII-- 107
Cdd:PRK02645  58 IDLAIVLGGDGTVLAA-ARHLAPHDIPilSVnVG---GHLGFLTH--PRDLlqdESVWDRLQEDRYAIERRMMLQARVfe 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 108 --RYVNGSKESQYLAMNEATVKSAEG----TLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQI 181
Cdd:PRK02645 132 gdRSNEEPVSESYYALNDFYLKPASEdrspTCILELEIDGEVVDQYQGDGLIVSTPTGSTAYTMAAGGPILHPGIDAIIV 211

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446595850 182 AEMA--SINNRvfrtvgsPLVLPKHHTCVLKPAAGMNLQI 219
Cdd:PRK02645 212 TPICpmSLSSR-------PIVIPPGSRVVIWPLGDYDLNI 244
ppnK PRK02155
NAD kinase;
30-246 4.23e-22

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 92.70  E-value: 4.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  30 TMDE--KEPDIVISVGGDGTLL---YAFHRYynrldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLE 104
Cdd:PRK02155  56 TPEEigARADLAVVLGGDGTMLgigRQLAPY-----GVPLIGINHGRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 105 V-IIRyvNGSKESQYLAMNEATV-KSAEGTLVT-EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQI 181
Cdd:PRK02155 131 ArVVR--DGEPIFHALAFNDVVVnRSGFSGMVElRVSVDGRFMYNQRSDGLIVATPTGSTAYALSAGGPILHPQLPGWVL 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 182 AEMA--SINNRvfrtvgsPLVLPKHHTCVLKPAAGMNLQITVD---HLTMVHQDvkSIQYRVANEKVRFV 246
Cdd:PRK02155 209 VPIAphTLSNR-------PIVLPDDSEVAIQIVGGRDVSVNFDmqsLTSLELGD--RIEVRRSPHTVRFL 269
pnk PRK14075
NAD(+) kinase;
35-185 9.41e-21

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 88.25  E-value: 9.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  35 EPDIVISVGGDGTLLYAFHRYYNRLdetafVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEViiryvnGSK 114
Cdd:PRK14075  41 TADLIIVVGGDGTVLKAAKKVGTPL-----VGFKAGRLGFLSSYTLEEIDRFLEDLKNWNFREEKRWFLKI------ESE 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446595850 115 ESQYLAMNEAT-VKSAEGTLVT-EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA 185
Cdd:PRK14075 110 LGNHLALNDVTlERDPSQKMVEiEVSFEDHSSMWFFADGVVISTPTGSTAYSLSLGGPIILPNCEVFEITPIA 182
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-190 1.36e-19

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 86.06  E-value: 1.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  37 DIVISVGGDGTLLYAFHRYYNRldETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLE-VIIRyvNGSKE 115
Cdd:PRK04539  70 DLVAVLGGDGTFLSVAREIAPR--AVPIIGINQGHLGFLTQIPREYMTDKLLPVLEGKYLAEERILIEaALIR--EGKTA 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446595850 116 SQYLAMNEATV-KSAEGTLVT-EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA--SINNR 190
Cdd:PRK04539 146 ERALALNDAVLsRGGAGQMIEfEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGLHAFTLVPICpqSMTNR 224
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
14-181 2.11e-18

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 84.39  E-value: 2.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  14 DTLASTMKEYLLDFGFTMDEKEpDI--VISVGGDGTLLYAfHRYYNRlDETAFVGVHTGHLGFYADWLPTEVEKLVIAIA 91
Cdd:PRK14076 326 SFLYNKLKNRLNEECNLIDDIE-EIshIISIGGDGTVLRA-SKLVNG-EEIPIICINMGTVGFLTEFSKEEIFKAIDSII 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  92 KTPFQVVEYPLLEVIIRYVNGSKESqYLAMNEATV--KSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGG 169
Cdd:PRK14076 403 SGEYEIEKRTKLSGFILKDGHQNIL-PSALNEVVIttKNPAKMLHFEVYVNGELVEEVRADGIIISTPTGSTAYSLSAGG 481

                        170
                 ....*....|..
gi 446595850 170 AIIHPSIEAIQI 181
Cdd:PRK14076 482 PIVEPTVDGFII 493
ppnK PRK03708
NAD(+) kinase;
1-248 3.08e-17

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 78.98  E-value: 3.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850   1 MKFTIMSKGD-QSSDTLASTMKEYLLDFGF--TMDEK-------------------EPDIVISVGGDGTLLYAFHryyNR 58
Cdd:PRK03708   1 MRFGIVARRDkEEALKLAYRVYDFLKVSGYevVVDSEtyehlpefseedvlpleemDVDFIIAIGGDGTILRIEH---KT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  59 LDETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEViirYVNGskESQYLAMNE-ATVKSAEGTLV-TE 136
Cdd:PRK03708  78 KKDIPILGINMGTLGFLTEVEPEETFFALSRLLEGDYFIDERIKLRV---YING--ENVPDALNEvVILTGIPGKIIhLK 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 137 VEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASinnrvFRTVGSPLVLPKHHTCVLKP-AAGM 215
Cdd:PRK03708 153 YYVDGELADEVRADGLIISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCP-----FKLSSRPMVVPSSSRIDVKLlRTGR 227

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446595850 216 NLQITVD--HLTMVHQDVKsIQYRVANEKVRFVRF 248
Cdd:PRK03708 228 EIILVIDgqYYEELPPDTE-ITIKKSPRKTKFVRF 261
ppnK PRK02231
NAD(+) kinase;
30-184 5.17e-17

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 78.31  E-value: 5.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  30 TMDE--KEPDIVISVGGDGTLLyAFHRYYNRLDeTAFVGVHTGHLGFYADWLP-TEVEKLVIAIAKTPFQVVEYPLLEVI 106
Cdd:PRK02231  35 SLEEigQRAQLAIVIGGDGNML-GRARVLAKYD-IPLIGINRGNLGFLTDIDPkNAYEQLEACLERGEFFVEERFLLEAK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 107 IRYvNGSKESQYLAMNEATVKSAE--GTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:PRK02231 113 IER-NGKIIATSNALNEVVIHPAKiaHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAIALVPM 191
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-181 9.28e-17

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 78.03  E-value: 9.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  37 DIVISVGGDGTLLyafhryynRLDETA------FVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRyV 110
Cdd:PRK03372  74 ELVLVLGGDGTIL--------RAAELAraadvpVLGVNLGHVGFLAEAEAEDLDEAVERVVDRDYRVEERMTLDVTVR-V 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446595850 111 NGSKESQYLAMNEATVKSA--EGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQI 181
Cdd:PRK03372 145 GGEIVWRGWALNEASLEKAdrEGMLEVVLEVDGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLV 217
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-184 9.43e-17

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 78.06  E-value: 9.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  37 DIVISVGGDGTLLYAfHRYYNRLDeTAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIrYVNGSKES 116
Cdd:PRK03378  65 DLAIVVGGDGNMLGA-ARVLARYD-IKVIGINRGNLGFLTDLDPDNALQQLSDVLEGHYISEKRFLLEAQV-CRHGQQKR 141

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446595850 117 QYLAMNEATVKSaeGTLVT----EVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEM 184
Cdd:PRK03378 142 ISTAINEVVLHP--GKVAHmiefEVYIDDNFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPM 211
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 20-206 2.05e-16

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 78.34  E-value: 2.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  20 MKEYLL----DFGFTM---DEKEP-------DIVISVGGDGTLLYAFHRYYNRLdeTAFVGVHTGHLGFYADWLPTEVEK 85
Cdd:PLN02935 233 VKKELLsessYFNFVQtweDEKEIlllhtkvDLVITLGGDGTVLWAASMFKGPV--PPVVPFSMGSLGFMTPFHSEQYRD 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  86 LVIAIAKTPFQVVEYPLLEV-IIRYVNGSK---ESQYLAMNEATVKSAEGTLVTEVEI--RGEYFETFRGDGLCISTPSG 159
Cdd:PLN02935 311 CLDAILKGPISITLRHRLQChIIRDAAKNEyetEEPILVLNEVTIDRGISSFLTNLECycDNSFVTCVQGDGLILSTTSG 390

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446595850 160 STAYNKALGGAIIHPSIEAIQIAEMASiNNRVFRtvgsPLVLPKHHT 206
Cdd:PLN02935 391 STAYSLAAGGSMVHPQVPGILFTPICP-HSLSFR----PLILPEYVT 432
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 32-172 2.73e-12

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 64.84  E-value: 2.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  32 DEKEPDIVISVGGDGTLLYAFHRYYNRldETAFVGVHTGHLGF----YADwlptevEKLVIAIAK-TPFQVveYPLLEVI 106
Cdd:PRK04761  22 PIEEADVIVALGGDGFMLQTLHRYMNS--GKPVYGMNRGSVGFlmneYSE------DDLLERIAAaEPTVL--HPLRMTA 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446595850 107 IRyVNGSKESqYLAMNE-----ATVKSAEgtlvTEVEIRG-EYFETFRGDGLCISTPSGSTAYNKALGGAII 172
Cdd:PRK04761  92 TD-VSGEVHE-ALAINEvslfrQTRQAAK----LRISIDGkVRMEELVCDGVLVATPAGSTAYNLSAHGPIL 157
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-247 7.53e-12

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 61.16  E-value: 7.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  121 MNEATVKSAEGTLV--TEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRvFRtvgsP 198
Cdd:pfam20143   1 LNEVVYVRGPGATMieFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLS-SR----P 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446595850  199 LVLPKHHTCVLKPAAGMN--LQITVDHLTMV-HQDVKSIqyRVANEKVRFVR 247
Cdd:pfam20143  76 IVVSSSSKLRIRVLSRAEalLVDDGDPELDIsPGDRVRV--RKSYYKAKFIR 125
ppnK PRK02649
NAD(+) kinase;
40-259 1.66e-11

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 63.07  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850  40 ISVGGDGTLLYAFHryynrldETAFVG-----VHTGHLGF----YADWLPTEVEKLViaiaKTPFQVVEYPLLEVIIrYV 110
Cdd:PRK02649  73 IVLGGDGTVLSAAR-------QLAPCGiplltINTGHLGFlteaYLNQLDEAIDQVL----AGQYTIEERTMLTVSV-MR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 111 NGSKESQYLAMNEATVKSAEGTLVTEVEIR-GEYFET-FRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMA--S 186
Cdd:PRK02649 141 GDQLRWEALSLNEMVLHREPLTSMCHFEIAiGRHAPVdIAADGVILSTPTGSTAYSLSAGGPVITPDVPVLQLTPICphS 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446595850 187 INNRVfrtvgspLVLPKHHTCVLKPAagmnlqiTVDHLTMV----------HQDvkSIQYRVANEKVRFVRFRPFPFWKR 256
Cdd:PRK02649 221 LASRA-------LVFSDSEPVTVFPA-------TPERLVMVvdgnagcyvwPED--RVLIRRSPYPVRFIRLQDPEFFRV 284


                 ...
gi 446595850 257 VRD 259
Cdd:PRK02649 285 LRE 287
PLN02727 PLN02727
NAD kinase
 148-176 2.28e-05

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 45.26  E-value: 2.28e-05
                         10        20
                 ....*....|....*....|....*....
gi 446595850 148 RGDGLCISTPSGSTAYNKALGGAIIHPSI 176
Cdd:PLN02727 862 QGDGVIVATPTGSTAYSTAAGGSMVHPNV 890
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH