NCBI Conserved Domain Search

Conserved domains on [gi|446596024|ref|WP_000673370|]

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MULTISPECIES: quorum sensing histidine kinase QseC [Enterobacteriaceae]

Protein Classification

two-component system sensor histidine kinase QseC( domain architecture ID 11484664)

two-component system sensor histidine kinase QseC is a member of the two-component regulatory system QseB/QseC that activates the flagella regulon by activating transcription of FlhD; QseC activates QseB by phosphorylation

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PRK10337

sensor protein QseC; Provisional

1-449

0e+00

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 891.31 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:PRK10337   1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLFAKRLSTLDLNELNAPDRMAQTPKKLKHGH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:PRK10337  81 VDDDALAFAIFTRDGKMVLNDGDNGEDIPYSYQREGFADGQLVGDDDLWRFVWLTSPDGKYRIVVGQEWEYREDMALAIV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 161 AGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF 240
Cdd:PRK10337 161 AGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 241 TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK10337 241 TSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 321 VMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADSFIVRDNGPGVTPEALARI 400
Cdd:PRK10337 321 VMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALARI 400

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 446596024 401 GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQGGFETKVSW 449
Cdd:PRK10337 401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449

Name

Accession

Description

Interval

E-value

PRK10337

sensor protein QseC; Provisional

1-449

0e+00

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 891.31 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:PRK10337   1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLFAKRLSTLDLNELNAPDRMAQTPKKLKHGH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:PRK10337  81 VDDDALAFAIFTRDGKMVLNDGDNGEDIPYSYQREGFADGQLVGDDDLWRFVWLTSPDGKYRIVVGQEWEYREDMALAIV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 161 AGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF 240
Cdd:PRK10337 161 AGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 241 TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK10337 241 TSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 321 VMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADSFIVRDNGPGVTPEALARI 400
Cdd:PRK10337 321 VMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALARI 400

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 446596024 401 GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQGGFETKVSW 449
Cdd:PRK10337 401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

340-449

1.51e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 156.41 E-value: 1.51e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 340 NAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS---FIVRDNGPGVTPEALARIGERFYRPPGQTATGSG 416
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446596024 417 LGLSIVQRIAKLHGMNVEFGNVEQGGFETKVSW 449
Cdd:cd16940   81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

141-442

4.37e-45

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 159.69 E-value: 4.37e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 141 YRIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLV 220
Cdd:COG0642   14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 221 ESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVaqLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLD 300
Cdd:COG0642   94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL--LLEELDEEQREYLETILRSADRLLRLINDLLDLSRLE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 301 SLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNA 380
Cdd:COG0642  172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446596024 381 DS----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:COG0642  252 EGdrvrISVEDTGPGIPPEDLERIFEPFFRtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

6-434

9.06e-39

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 145.61 E-value: 9.06e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024    6 RLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLK---HGHVD 82
Cdd:TIGR01386   1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEDIKRLQEKIDdllVGHSD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   83 ddaLTFAIFTHDGRMVL------------NDGDNGEDIPYSYQREGfADGQLVGEDDPWRFVWMTSPdgkYRIVVGQEWE 150
Cdd:TIGR01386  81 ---LALSILNPDGRLLFeraqgaalvpavAANDALLELDQADAKMT-HYRSILRSVAALPGGKGRKP---VQITVALDIN 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  151 YREDMaLAivagQLIPWLVALPIMLIIMMVLLGR-----ELAPLNKL-ALALRMRDPDSEKPLNATGVPSEVRPLVESLN 224
Cdd:TIGR01386 154 AHTHL-LD----ALRKWLILIAVLLVLLTALLGWwitrlGLEPLRRLsAVAARISPESLDQRLDPSRAPAELRELAQSFN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  225 QLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAqLSDDDPQARKKALLqlHSGID---RATRLVDQLLTLSRLDS 301
Cdd:TIGR01386 229 AMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVA-LSQPRTGEEYREVL--ESNLEeleRLSRMVSDMLFLARADN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  302 LDNLQDVAEIPLEDLLqSSVMDIYHTAQQAKiDVRLTLNAHGIKRtGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNAD 381
Cdd:TIGR01386 306 GQLALERVRLDLAAEL-AKVAEYFEPLAEER-GVRIRVEGEGLVR-GDPQMFRRAISNLLSNALRHTPDGGTITVRIERR 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  382 SFIVR----DNGPGVTPEALARIGERFYR-PPGQT--ATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:TIGR01386 383 SDEVRvsvsNPGPGIPPEHLSRLFDRFYRvDPARSnsGEGTGLGLAIVRSIMEAHGGRAS 442

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

362-442

5.23e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 90.40 E-value: 5.23e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   362 DNAVRYSPQGSVVDITLNAD----SFIVRDNGPGVTPEALARIGERFYR--PPGQTATGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRtdKRSRKIGGTGLGLSIVKKLVELHGGEISV 94


                   ....*..
gi 446596024   436 GNVEQGG 442
Cdd:smart00387  95 ESEPGGG 101

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

362-442

8.53e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 89.73 E-value: 8.53e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  362 DNAVRYSPQGSVVDITLNAD---SFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNV 438
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLVELLGGTITVESE 94


                  ....
gi 446596024  439 EQGG 442
Cdd:pfam02518  95 PGGG 98

Name

Accession

Description

Interval

E-value

PRK10337

sensor protein QseC; Provisional

1-449

0e+00

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 891.31 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:PRK10337   1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLFAKRLSTLDLNELNAPDRMAQTPKKLKHGH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:PRK10337  81 VDDDALAFAIFTRDGKMVLNDGDNGEDIPYSYQREGFADGQLVGDDDLWRFVWLTSPDGKYRIVVGQEWEYREDMALAIV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 161 AGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF 240
Cdd:PRK10337 161 AGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 241 TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK10337 241 TSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 321 VMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADSFIVRDNGPGVTPEALARI 400
Cdd:PRK10337 321 VMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPEALARI 400

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 446596024 401 GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQGGFETKVSW 449
Cdd:PRK10337 401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

340-449

1.51e-46

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 156.41 E-value: 1.51e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 340 NAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS---FIVRDNGPGVTPEALARIGERFYRPPGQTATGSG 416
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446596024 417 LGLSIVQRIAKLHGMNVEFGNVEQGGFETKVSW 449
Cdd:cd16940   81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

141-442

4.37e-45

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 159.69 E-value: 4.37e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 141 YRIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLV 220
Cdd:COG0642   14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 221 ESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVaqLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLD 300
Cdd:COG0642   94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL--LLEELDEEQREYLETILRSADRLLRLINDLLDLSRLE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 301 SLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNA 380
Cdd:COG0642  172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446596024 381 DS----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:COG0642  252 EGdrvrISVEDTGPGIPPEDLERIFEPFFRtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

143-430

6.55e-44

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 158.18 E-value: 6.55e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 143 IVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVES 222
Cdd:COG5002   71 LLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 223 LNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAQLS-DDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDS 301
Cdd:COG5002  151 VERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLES 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 302 LDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNAD 381
Cdd:COG5002  231 GELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREE 310

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446596024 382 S----FIVRDNGPGVTPEALARIGERFYR---PPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:COG5002  311 DdqvrISVRDTGIGIPEEDLPRIFERFYRvdkSRSRETGGTGLGLAIVKHIVEAHG 366

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

238-442

4.96e-42

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 148.90 E-value: 4.96e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQ-LHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDL 316
Cdd:COG2205   17 SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEiIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAEL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 317 LQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS----FIVRDNGPGV 392
Cdd:COG2205   97 LEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGdgvrISVSDNGPGI 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446596024 393 TPEALARIGERFYRPPGQTAT-GSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:COG2205  177 PEEELERIFERFYRGDNSRGEgGTGLGLAIVKRIVEAHGGTIWVESEPGGG 227

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

6-434

9.06e-39

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 145.61 E-value: 9.06e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024    6 RLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLK---HGHVD 82
Cdd:TIGR01386   1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEDIKRLQEKIDdllVGHSD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   83 ddaLTFAIFTHDGRMVL------------NDGDNGEDIPYSYQREGfADGQLVGEDDPWRFVWMTSPdgkYRIVVGQEWE 150
Cdd:TIGR01386  81 ---LALSILNPDGRLLFeraqgaalvpavAANDALLELDQADAKMT-HYRSILRSVAALPGGKGRKP---VQITVALDIN 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  151 YREDMaLAivagQLIPWLVALPIMLIIMMVLLGR-----ELAPLNKL-ALALRMRDPDSEKPLNATGVPSEVRPLVESLN 224
Cdd:TIGR01386 154 AHTHL-LD----ALRKWLILIAVLLVLLTALLGWwitrlGLEPLRRLsAVAARISPESLDQRLDPSRAPAELRELAQSFN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  225 QLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAqLSDDDPQARKKALLqlHSGID---RATRLVDQLLTLSRLDS 301
Cdd:TIGR01386 229 AMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVA-LSQPRTGEEYREVL--ESNLEeleRLSRMVSDMLFLARADN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  302 LDNLQDVAEIPLEDLLqSSVMDIYHTAQQAKiDVRLTLNAHGIKRtGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNAD 381
Cdd:TIGR01386 306 GQLALERVRLDLAAEL-AKVAEYFEPLAEER-GVRIRVEGEGLVR-GDPQMFRRAISNLLSNALRHTPDGGTITVRIERR 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  382 SFIVR----DNGPGVTPEALARIGERFYR-PPGQT--ATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:TIGR01386 383 SDEVRvsvsNPGPGIPPEHLSRLFDRFYRvDPARSnsGEGTGLGLAIVRSIMEAHGGRAS 442

PRK10755

two-component system sensor histidine kinase PmrB;

148-429

1.41e-36

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 137.41 E-value: 1.41e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 148 EWEYREdmalaIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLF 227
Cdd:PRK10755  53 MKEIRE-----AVASLLVPSLVMVSLTLLICFQAVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 228 ARTHAMMVRERRFTSDAAHELRSPLTALKVQTEV-AQLSDDDPQArkkallqLHSGIDRATRLVDQLLTLSRL------- 299
Cdd:PRK10755 128 SRLTSTLDQERLFTADVAHELRTPLAGIRLHLELlEKQHHIDVAP-------LIARLDQMMHTVEQLLQLARAgqsfssg 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 300 --DSLDNLQDVAeIPLEDLLqsSVMdiyhtAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDIT 377
Cdd:PRK10755 201 hyQTVKLLEDVI-LPSQDEL--SEM-----LEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIK 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446596024 378 LNAD----SFIVRDNGPGVTPEALARIGERFYRpPGQTATGSGLGLSIVQRIAKLH 429
Cdd:PRK10755 273 LSQEdggaVLAVEDEGPGIDESKCGELSKAFVR-MDSRYGGIGLGLSIVSRITQLH 327

PRK11100

sensory histidine kinase CreC; Provisional

245-442

5.59e-31

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 124.19 E-value: 5.59e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALKVQTEVaqLSDDDPQARKKALLqlhSGID----RATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS 320
Cdd:PRK11100 264 THELKSPLAAIRGAAEL--LQEDPPPEDRARFT---GNILtqsaRLQQLIDRLLELARLEQRQELEVLEPVALAALLEEL 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 321 VMDIYHTAQQAKIDVRLTLNAHGIKrtGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS----FIVRDNGPGVtPE- 395
Cdd:PRK11100 339 VEAREAQAAAKGITLRLRPDDARVL--GDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGeqvaLSVEDQGPGI-PDy 415

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446596024 396 ALARIGERFY---RPPGQTaTGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:PRK11100 416 ALPRIFERFYslpRPANGR-KSTGLGLAFVREVARLHGGEVTLRNRPEGG 464

HATPase

cd00075

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...

362-449

8.88e-25

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.

Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 97.67 E-value: 8.88e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSPQGSVVDITLNADS----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFG 436
Cdd:cd00075   10 DNALKYSPPGGTIEISLRQEGdgvvLEVEDNGPGIPEEDLERIFERFYRgDKSREGGGTGLGLAIVRRIVEAHGGRITVE 89

                         90
                 ....*....|...
gi 446596024 437 NVEQGGFETKVSW 449
Cdd:cd00075   90 SEPGGGTTFTVTL 102

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

174-433

5.63e-23

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 101.00 E-value: 5.63e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 174 MLIIMMVLLG--RELAPLNKLALALR-MRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRS 250
Cdd:PRK09835 196 LLIVFIVLLAvhKGHAPIRSVSRQIQnITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 251 PLTALKVQTEVAqLSdddpQARKKALLQ--LHSGID---RATRLVDQLLTLSRldsLDNLQDVAEIPLEDLLQS--SVMD 323
Cdd:PRK09835 276 PITNLITQTEIA-LS----QSRSQKELEdvLYSNLEeltRMAKMVSDMLFLAQ---ADNNQLIPEKKMLDLADEvgKVFD 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 324 IYHTAQQAKiDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITL----NADSFIVRDNGPGVTPEALAR 399
Cdd:PRK09835 348 FFEAWAEER-GVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCqevdHQVQLVVENPGTPIAPEHLPR 426

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 446596024 400 IGERFYR--PPGQ-TATGSGLGLSIVQRIAKLHGMNV 433
Cdd:PRK09835 427 LFDRFYRvdPSRQrKGEGSGIGLAIVKSIVVAHKGTV 463

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

362-442

5.23e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 90.40 E-value: 5.23e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   362 DNAVRYSPQGSVVDITLNAD----SFIVRDNGPGVTPEALARIGERFYR--PPGQTATGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRtdKRSRKIGGTGLGLSIVKKLVELHGGEISV 94


                   ....*..
gi 446596024   436 GNVEQGG 442
Cdd:smart00387  95 ESEPGGG 101

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

238-423

6.42e-22

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 97.39 E-value: 6.42e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDS--LDNLQDVAEIPLE- 314
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAapTIDLNEKVDVPMMl 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 315 DLLQSSVMDIYHTAQQAKIDVRltlnaHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDI----TLNADSFIVRDNGP 390
Cdd:PRK11006 285 RVLEREAQTLSQGKHTITFEVD-----NSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVrwqrVPQGAEFSVEDNGP 359

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446596024 391 GVTPEALARIGERFYR----PPGQTAtGSGLGLSIVQ 423
Cdd:PRK11006 360 GIAPEHIPRLTERFYRvdkaRSRQTG-GSGLGLAIVK 395

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

362-442

8.53e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 89.73 E-value: 8.53e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  362 DNAVRYSPQGSVVDITLNAD---SFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNV 438
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLVELLGGTITVESE 94


                  ....
gi 446596024  439 EQGG 442
Cdd:pfam02518  95 PGGG 98

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

142-442

6.48e-21

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 93.71 E-value: 6.48e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 142 RIVVGQEWEYREDMALAIVAGQLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVE 221
Cdd:COG4191   42 LLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELER 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 222 SLNQLfARTHAMMVR-ER-----RFTSDAAHELRSPLTALKVQTEVAQL---SDDDPQARKKALLQLHSGIDRATRLVDQ 292
Cdd:COG4191  122 AEEEL-RELQEQLVQsEKlaalgELAAGIAHEINNPLAAILGNAELLRRrleDEPDPEELREALERILEGAERAAEIVRS 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 293 LLTLSRLDSldnlQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVR-----------------------LTLNA-HGIKRTG 348
Cdd:COG4191  201 LRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVEldlppdlppvlgdpgqleqvllnLLINAiDAMEEGE 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 349 QPLLLsllvrnlldnaVRYSPQGSVVDITlnadsfiVRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIA 426
Cdd:COG4191  277 GGRIT-----------ISTRREGDYVVIS-------VRDNGPGIPPEVLERIFEPFFttKPVGK---GTGLGLSISYGIV 335

                        330
                 ....*....|....*.
gi 446596024 427 KLHGMNVEFGNVEQGG 442
Cdd:COG4191  336 EKHGGRIEVESEPGGG 351

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

245-442

6.25e-20

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 91.56 E-value: 6.25e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALK-----VQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNlqdvAEIPLEDLLQS 319
Cdd:COG5000  209 AHEIKNPLTPIQlsaerLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQL----EPVDLNELLRE 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 320 SVMDIYHTAQQAKIDVRLTLNAHGIKRTGqplllsllvrnllD-------------NAVRYSPQGSVVDITLNADS---- 382
Cdd:COG5000  285 VLALYEPALKEKDIRLELDLDPDLPEVLA-------------DrdqleqvlinllkNAIEAIEEGGEIEVSTRREDgrvr 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446596024 383 FIVRDNGPGVTPEALARIGERFYrppgqT--ATGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:COG5000  352 IEVSDNGPGIPEEVLERIFEPFF-----TtkPKGTGLGLAIVKKIVEEHGGTIELESRPGGG 408

KinC

COG5807

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...

237-442

1.20e-19

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 89.84 E-value: 1.20e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 237 ERRFTSDAAHELRSPLTALK--VQTEVAQLSDDDPQARKKALLqlhSGIDRATRLVDQLLTLSRldslDNLQDVAEIPLE 314
Cdd:COG5807  147 AGELAAGIAHEIRNPLTSIKgfLQLLQESREDSEREEYFNIII---SEIDRINTIITELLVLSK----PKKFNFKKLNLN 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 315 DLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS----FIVRDNGP 390
Cdd:COG5807  220 DVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGdfvvISVKDEGI 299

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446596024 391 GVTPEALARIGERFYRPPGQtatGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:COG5807  300 GIPEEVLEKIGEPFFTTKEE---GTGLGLSICKKIIEEHNGTIEVESKPGKG 348

PRK10604

sensor protein RstB; Provisional

224-449

9.25e-19

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 88.12 E-value: 9.25e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 224 NQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVA-QLSDDDPQARKKALLQLHSgidratrLVDQLLTLSRLDSL 302
Cdd:PRK10604 199 NQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSdNLSAAESQALNRDIGQLEA-------LIEELLTYARLDRP 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 303 DNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDvrLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNAD- 381
Cdd:PRK10604 272 QNELHLSEPDLPAWLSTHLADIQAVTPEKTVR--LDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNq 349

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446596024 382 -SFIVRDNGPGVTPEALARIGERFYR--PPGQTATGS-GLGLSIVQRIAKLHGMNVEFGNVEQGGFETKVSW 449
Cdd:PRK10604 350 aCLIVEDDGPGIPPEERERVFEPFVRldPSRDRATGGcGLGLAIVHSIALAMGGSVNCDESELGGARFSFSW 421

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

166-429

3.89e-17

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 83.44 E-value: 3.89e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 166 PWLVALPIMLII--MMVLLGRELA-PLNKLALA--------LRMrDPDSEkplnaTGvPSEVRPLVESLNQLFARTHAMM 234
Cdd:PRK09470 168 PLLLLLVTMLVStpLLLWLAWSLAkPARKLKNAadevaqgnLRQ-HPELE-----TG-PQEFRQAGASFNQMVTALERMM 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 235 VRERRFTSDAAHELRSPLTALKVQTevaqlsdddpqarkkALLQLHSG-------ID-RATRL---VDQLLTLSRlDSLD 303
Cdd:PRK09470 241 TSQQRLLSDISHELRTPLTRLQLAT---------------ALLRRRQGeskelerIEtEAQRLdsmINDLLVLSR-NQQK 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 304 NLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDvrLTLNAHGIKRT--GQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNAD 381
Cdd:PRK09470 305 NHLERETFKANSLWSEVLEDAKFEAEQMGKS--LTVSAPPGPWPinGNPNALASALENIVRNALRYSHTKIEVAFSVDKD 382

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446596024 382 --SFIVRDNGPGVTPEALARIGERFYRPpgQTAT-----GSGLGLSIVQRIAKLH 429
Cdd:PRK09470 383 glTITVDDDGPGVPEEEREQIFRPFYRV--DEARdresgGTGLGLAIVENAIQQH 435

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

1-430

5.36e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 83.30 E-value: 5.36e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024   1 MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH 80
Cdd:COG4251   61 LLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEEL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  81 VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV 160
Cdd:COG4251  141 ALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLS 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 161 AG-QLIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATgvpseVRPLVESLNQLfarthammvreRR 239
Cdd:COG4251  221 LGgGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEER-----TAELERSNEEL-----------EQ 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 240 FTSDAAHELRSPLTALKVQTE--VAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDnlQDVAEIPLEDLL 317
Cdd:COG4251  285 FAYVASHDLREPLRKISGFSQllEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELL 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 318 QSSVMDIYHTAQQAKIDVRL----TLNAHG----------IkrtgqplllsllvrnllDNAVRYSPQGSVVDITLNADS- 382
Cdd:COG4251  363 EEVLEDLEPRIEERGAEIEVgplpTVRGDPtllrqvfqnlI-----------------SNAIKYSRPGEPPRIEIGAERe 425

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446596024 383 -----FIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:COG4251  426 ggewvFSVRDNGIGIDPEYAEKIFEIFQRlHSRDEYEGTGIGLAIVKKIVERHG 479

KinD

COG5808

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...

240-435

1.13e-16

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 81.72 E-value: 1.13e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 240 FTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKaLLQLHSGIDRATRLVDQLLTLSRLDSldnlQDVAEIPLEDLLQS 319
Cdd:COG5808  244 FAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKY-FDIIQEEIQRINQIVSEFLVLGKPTA----KKLELDDLNELIEE 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 320 SVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS----FIVRDNGPGVTPE 395
Cdd:COG5808  319 ILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDekavIEVIDNGEGIPED 398

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446596024 396 ALARIGERFYRPPGqtaTGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:COG5808  399 IIDEIFEPFVTTKE---GGTGLGLSVCKRIVEMHGGEIDI 435

PRK10549

two-component system sensor histidine kinase BaeS;

215-430

1.77e-16

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 81.22 E-value: 1.77e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 215 EVRPLVESLNQLfARTHAMMVRERR-FTSDAAHELRSPLTALKVQTEVAQlsDDDPQARKKALLQLHSGIDRATRLVDQL 293
Cdd:PRK10549 218 ELGRLAQDFNQL-ASTLEKNEQMRRdFMADISHELRTPLAVLRGELEAIQ--DGVRKFTPESVASLQAEVGTLTKLVDDL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 294 --LTLSRLDSLDNLQdvAEIPLEDLLQSSVMDIYH--TAQQAKIDVRLTLNAhgiKRTGQPLLLSLLVRNLLDNAVRYSP 369
Cdd:PRK10549 295 hqLSLSDEGALAYRK--TPVDLVPLLEVAGGAFRErfASRGLTLQLSLPDSA---TVFGDPDRLMQLFNNLLENSLRYTD 369

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446596024 370 QGSVVDITLN--ADSFIV--RDNGPGVTPEALARIGERFYRPPG---QTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK10549 370 SGGSLHISAEqrDKTLRLtfADSAPGVSDEQLQKLFERFYRTEGsrnRASGGSGLGLAICLNIVEAHN 437

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

245-430

5.66e-16

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 79.12 E-value: 5.66e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALKVQTEVAQLSDDDPQARKkaLLQL-HSGIDRATRLVDQLLTLSRLDSLD----NLQDVAE--------- 310
Cdd:COG3852  143 AHEIRNPLTGIRGAAQLLERELPDDELRE--YTQLiIEEADRLNNLVDRLLSFSRPRPPErepvNLHEVLErvlellrae 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 311 --------------IPL----EDLLQSSVMDIYHTAQQA-----KIDVRlTLNAHGIKRTGQPLllsllvrnlldnavry 367
Cdd:COG3852  221 apknirivrdydpsLPEvlgdPDQLIQVLLNLVRNAAEAmpeggTITIR-TRVERQVTLGGLRP---------------- 283

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446596024 368 spqGSVVDITlnadsfiVRDNGPGVTPEALARIGERFYrppgqT--ATGSGLGLSIVQRIAKLHG 430
Cdd:COG3852  284 ---RLYVRIE-------VIDNGPGIPEEILDRIFEPFF-----TtkEKGTGLGLAIVQKIVEQHG 333

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-442

3.12e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.34 E-value: 3.12e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSPQGSVVDITLNADS----FIVRDNGPGVTPEALARIGERFY---RPPGQTATgSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16945   14 DNAIDFSPEGGLIALQLEADTegieLLVFDEGSGIPDYALNRVFERFYslpRPHSGQKS-TGLGLAFVQEVAQLHGGRIT 92


                 ....*...
gi 446596024 435 FGNVEQGG 442
Cdd:cd16945   93 LRNRPDGV 100

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

363-444

9.17e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 66.97 E-value: 9.17e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 363 NAVRYSPQGSVVDITLNAD--SFIVRDNGPGVTPEALARIGERFYRP--PGQTAT-GSGLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16949   11 NALRYSPSKILLDISQDGDqwTITITDDGPGVPEDQLEQIFLPFYRVdsARDRESgGTGLGLAIAERAIEQHGGKIKASN 90


                 ....*..
gi 446596024 438 VEQGGFE 444
Cdd:cd16949   91 RKPGGLR 97

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-442

2.85e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 65.95 E-value: 2.85e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSPQGSVVDI----TLNADSFIVRDNGPGVTPEALARIGERFYRPPG---QTATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16946   14 ENSLRYTDTGGKLRIraaqTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESsrnRASGGSGLGLAICHNIALAHGGTIS 93


                 ....*...
gi 446596024 435 FGNVEQGG 442
Cdd:cd16946   94 AEHSPLGG 101

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

363-449

4.43e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 65.14 E-value: 4.43e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 363 NAVRYSPQGSVVDITLNADS--FIVRDNGPGVTPEALARIGERFYR--PPGQTATGS-GLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16939   11 NALRYAHRTVRIALLVSGGRltLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGfGLGLAIVHRVALWHGGHVECDD 90

                         90
                 ....*....|..
gi 446596024 438 VEQGGFETKVSW 449
Cdd:cd16939   91 SELGGACFRLTW 102

PRK11360

two-component system sensor histidine kinase AtoS;

233-434

5.37e-13

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 70.77 E-value: 5.37e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 233 MMVRER-----RFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKkALLQLHSGIDRATRLVDQLLTLSRlDSLDNLQD 307
Cdd:PRK11360 381 VARQERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQE-YLSVVLREVDRLNKVIDQLLEFSR-PRESQWQP 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 308 VAeipLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDIT--LNADSFI- 384
Cdd:PRK11360 459 VS---LNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRtwQYSDGQVa 535

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446596024 385 --VRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:PRK11360 536 vsIEDNGCGIDPELLKKIFDPFFT---TKAKGTGLGLALSQRIINAHGGDIE 584

envZ

PRK09467

osmolarity sensor protein; Provisional

174-448

5.80e-13

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 70.32 E-value: 5.80e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 174 MLIIMMVLLG---------RELAPLNKLALALRMRD-PDsekPLNATGVpSEVRPLVESLNQLfARTHAMMVRERRF-TS 242
Cdd:PRK09467 160 LAIGLLSVAGgwlfiriqnRPLVALEHAALQVGKGEiPP---PLREYGA-SEVRSVTRAFNQM-AAGIKQLEDDRTLlMA 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 243 DAAHELRSPLTALKVQTEVaqLSDDDpQARKKALLqlhSGIDRATRLVDQLLTLSRLDSLDNLQ--DVAEIpLEDLLQSs 320
Cdd:PRK09467 235 GVSHDLRTPLTRIRLATEM--MSEED-GYLAESIN---KDIEECNAIIEQFIDYLRTGQEMPMEmaDLNAL-LGEVIAA- 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 321 vmdiyHTAQQAKIDvrLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSpqGSVVDITLNADS----FIVRDNGPGVTPEA 396
Cdd:PRK09467 307 -----ESGYEREIE--TALQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGkrawFQVEDDGPGIPPEQ 377

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446596024 397 LARIGERFYRppGQTA---TGSGLGLSIVQRIAKLHGMNVEFGNVEQGGFETKVS 448
Cdd:PRK09467 378 LKHLFQPFTR--GDSArgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAW 430

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-447

1.34e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 63.62 E-value: 1.34e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSpQGSV---VDITLNADSFIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16950   10 DNALRYG-GGWVevsSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRgDNARGTSGTGLGLAIVQRISDAHGGSLTLAN 88

                         90
                 ....*....|
gi 446596024 438 VEQGGFETKV 447
Cdd:cd16950   89 RAGGGLCARI 98

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

363-447

2.70e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 62.86 E-value: 2.70e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 363 NAVRYSPQGSVVDITLNAD----SFIVRDNGPGVTPEALARIGERFYRppGQTATGS----GLGLSIVQRIAKLHGMNVE 434
Cdd:cd16975   15 NACQYAPEGGTVSISIYDEeeylYFEIWDNGHGFSEQDLKKALELFYR--DDTSRRSgghyGMGLYIAKNLVEKHGGSLI 92

                         90
                 ....*....|...
gi 446596024 435 FGNVEQGGFETKV 447
Cdd:cd16975   93 IENSQKGGAEVTV 105

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

245-442

3.31e-12

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 68.08 E-value: 3.31e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALKVQTEVAQLSDDDPQarKKALLQLHSGIDRATRLVDQLLTLSRLDSLDnlqdVAEIPLEDLLQSsVMDI 324
Cdd:COG5809  278 AHEIRNPLTSLKGFIQLLKDTIDEEQ--KTYLDIMLSELDRIESIISEFLVLAKPQAIK----YEPKDLNTLIEE-VIPL 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 325 YHTaqQA---KIDVRLTLNAH--GIKrtGQPLLLSLLVRNLLDNAVRYSP-QGSV-VDITLNADSFI---VRDNGPGVTP 394
Cdd:COG5809  351 LQP--QAllkNVQIELELEDDipDIL--GDENQLKQVFINLLKNAIEAMPeGGNItIETKAEDDDKVvisVTDEGCGIPE 426

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446596024 395 EALARIGERFYrppgqTA--TGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:COG5809  427 ERLKKLGEPFY-----TTkeKGTGLGLMVSYKIIEEHGGKITVESEVGKG 471

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

234-298

3.38e-12

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.46 E-value: 3.38e-12

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446596024 234 MVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSR 298
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

245-432

3.91e-12

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 67.58 E-value: 3.91e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALKVQTEVAQlSDDDPQARKKALLQLH-SGIDRATRLVDQLLTLSRLDSlDNLQdvaEIPLEDLLQSSVMD 323
Cdd:COG5806  209 AHEVRNPLTVVRGFIQLLQ-EPELSDEKRKQYIRIAlEELDRAEAIITDYLTFAKPQP-EKLE---KIDVSEELEHVIDV 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 324 IYHTAQQAKIDVRLTLNaHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS----FIVRDNGPGVTPEALAR 399
Cdd:COG5806  284 LSPYANMNNVEIQTELE-PGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKEQLER 362

                        170       180       190
                 ....*....|....*....|....*....|...
gi 446596024 400 IGERFYrppGQTATGSGLGLSIVQRIakLHGMN 432
Cdd:COG5806  363 LGEPYF---STKEKGTGLGTMVSYRI--IEAMN 390

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

363-430

4.39e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 62.51 E-value: 4.39e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446596024 363 NAVRYSPQGSV-VDITLNADS-------FIVRDNGPGVTPEALARIGERFYRPPGQT---ATGSGLGLSIVQRIAKLHG 430
Cdd:cd16922   11 NAIKFTEEGEVtLRVSLEEEEedgvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTtrkYGGTGLGLAISKKLVELMG 89

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

363-429

8.91e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 61.45 E-value: 8.91e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446596024 363 NAVRYSPQGSVVDITLNADS----FIVRDNGPGVTPEALARIGERFYRPPGQTAT---GSGLGLSIVQRIAKLH 429
Cdd:cd16952   11 NAVKYTPPSDTITVRWSQEEsgarLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntgGTGLGLAIVKHVMSRH 84

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

238-301

3.36e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.73 E-value: 3.36e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446596024   238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQaRKKALLQLHSGIDRATRLVDQLLTLSRLDS 301
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEE-QREYLETILREAERLLRLINDLLDLSRIEA 65

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-442

4.53e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 59.51 E-value: 4.53e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSPQGS---VVDITLNADSFI--VRDNGPGVTPEALARIGERFY--RPPGQT-ATGSGLGLSIVQRIAKLHGMNV 433
Cdd:cd16953   10 GNAISFSPPDTgriTVSAMPTGKMVTisVEDEGPGIPQEKLESIFDRFYteRPANEAfGQHSGLGLSISRQIIEAHGGIS 89


                 ....*....
gi 446596024 434 EFGNVEQGG 442
Cdd:cd16953   90 VAENHNQPG 98

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

238-301

8.91e-11

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.22 E-value: 8.91e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446596024  238 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARkKALLQLHSGIDRATRLVDQLLTLSRLDS 301
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQR-EYLETILRSAERLLRLINDLLDLSRIEA 65

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

363-442

1.94e-10

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 57.89 E-value: 1.94e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 363 NAVRYSPQGSVVDITLNADS-----FIVRDNGPGVTPEALARIGERFYR---PPGQTATGSGLGLSIVQRIAKLHGMNVE 434
Cdd:cd16925   15 NAFKFTPDGGRIRCILEKFRlnrflLTVSDSGPGIPPNLREEIFERFRQgdgSSTRAHGGTGLGLSIVKEFVELHGGTVT 94


                 ....*...
gi 446596024 435 FGNVEQGG 442
Cdd:cd16925   95 VSDAPGGG 102

PRK10490

sensor protein KdpD; Provisional

246-442

2.45e-10

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 62.75 E-value: 2.45e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 246 HELRSPLTALKVQTEVAQL---SDDDPQARKKAllQLHSGIDRATRLVDQLLTLSRLDSlDNLQDVAE-IPLEDLLQSSV 321
Cdd:PRK10490 673 HDLRTPLTVLFGQAEILTLdlaSEGSPHARQAS--EIRQQVLNTTRLVNNLLDMARIQS-GGFNLRKEwLTLEEVVGSAL 749

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 322 MDIYHTAQQAKIDVRLT-----LNAHG--IKRTgqplllsllVRNLLDNAVRYSpqGSVVDITLNAD------SFIVRDN 388
Cdd:PRK10490 750 QMLEPGLSGHPINLSLPepltlIHVDGplFERV---------LINLLENAVKYA--GAQAEIGIDAHvegerlQLDVWDN 818

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446596024 389 GPGVTPEALARIGERFYRPPGQTAT-GSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:PRK10490 819 GPGIPPGQEQLIFDKFARGNKESAIpGVGLGLAICRAIVEVHGGTIWAENRPEGG 873

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

245-429

2.72e-10

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 62.06 E-value: 2.72e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALKVQTEVAQLSDDDpqarKKALLQLH-SGIDRATRLVDQLLTLSRLDSldnlQDVAEIPLEDLLQSSVMD 323
Cdd:COG5805  295 AHEIRNPLTSIKGFLQLLQPGIED----KEEYFDIMlSELDRIESIISEFLALAKPQA----VNKEKENINELIQDVVTL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 324 IYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDI-TLNADSFI---VRDNGPGVTPEALAR 399
Cdd:COG5805  367 LETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIhTEEEDNSViirVIDEGIGIPEERLKK 446

                        170       180       190
                 ....*....|....*....|....*....|.
gi 446596024 400 IGERFYrppgQTAT-GSGLGLSIVQRIAKLH 429
Cdd:COG5805  447 LGEPFF----TTKEkGTGLGLMVSYKIIENH 473

PRK09303

histidine kinase;

245-430

2.85e-10

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 61.51 E-value: 2.85e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTA--LKVQTeVAQLSDDDPQARKKALL-QLHSGIDRATRLVDQLLTlsrldslDNLQdVAEIPLEDL-LQSS 320
Cdd:PRK09303 159 AHDLRTPLTAasLALET-LELGQIDEDTELKPALIeQLQDQARRQLEEIERLIT-------DLLE-VGRTRWEALrFNPQ 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 321 VMDIYHTAQQAKIDVRLTLNAHGIKRT-----------GQPLLLSLLVRNLLDNAVRYSPQGSVVDIT-LNADS----FI 384
Cdd:PRK09303 230 KLDLGSLCQEVILELEKRWLAKSLEIQtdipsdlpsvyADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTqkvqVS 309

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446596024 385 VRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK09303 310 ICDTGPGIPEEEQERIFEDRVRlPRDEGTEGYGIGLSVCRRIVRVHY 356

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

363-430

2.88e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 57.01 E-value: 2.88e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446596024 363 NAVRYSPQGSVVDItlnaDSFIVRDN--------GPGVTPEALARIGERFYRppGQTA---TGSGLGLSIVQRIAKLHG 430
Cdd:cd16923   11 NAIKYSPENTRIYI----TSFLTDDVvnimfknpSSHPLDFKLEKLFERFYR--GDNSrntEGAGLGLSIAKAIIELHG 83

PRK10364

two-component system sensor histidine kinase ZraS;

245-430

3.13e-10

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 61.73 E-value: 3.13e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 245 AHELRSPLTALK-VQTEVAQLSDDDPQARKKALLqLHSGIDRATRLVDQLLTLSRLDSLdNLQDVAeipLEDLLQSSVMD 323
Cdd:PRK10364 245 AHEIRNPLSSIKgLAKYFAERAPAGGEAHQLAQV-MAKEADRLNRVVSELLELVKPTHL-ALQAVD---LNDLINHSLQL 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 324 IYHTAQQAKIDVRLTLNAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADS----FIVRDNGPGVTPEALAR 399
Cdd:PRK10364 320 VSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGagvkISVTDSGKGIAADQLEA 399

                        170       180       190
                 ....*....|....*....|....*....|.
gi 446596024 400 IGERFYRPPGQtatGSGLGLSIVQRIAKLHG 430
Cdd:PRK10364 400 IFTPYFTTKAE---GTGLGLAVVHNIVEQHG 427

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

373-442

5.13e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 53.58 E-value: 5.13e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446596024 373 VVDITLNADSFI--VRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:cd16943   26 TIRTWAHVDQVLieVEDTGSGIDPEILGRIFDPFFttKPVGE---GTGLGLSLSYRIIQKHGGTIRVASVPGGG 96

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-433

1.23e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 52.33 E-value: 1.23e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446596024 362 DNAVRYSPQGSVVDITLNAD------SFIVRDNGPGVTPEALARIGERFYRPPGQTAT-GSGLGLSIVQRIAKLHGMNV 433
Cdd:cd16921   10 GNAIKFRRPRRPPRIEVGAEdvgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYeGTGVGLAIVRKIIERHGGRI 88

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

164-449

4.51e-08

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 55.02 E-value: 4.51e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 164 LIPWLVALPIMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGvPSEVRPLVESLNQLFARTHAMMVRERRftsd 243
Cdd:COG2972  160 LLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVERIKELIEEVYE---- 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 244 aahelrspLTALKVQTEVAQLsdddpQARK------------KALLQLHsGIDRATRLVDQLLTLSRlDSLDNLQDVaeI 311
Cdd:COG2972  235 --------LELEKKEAELKAL-----QAQInphflfntlnsiRWLAELE-DPEEAEEMLEALSKLLR-YSLSKGDEL--V 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 312 PLED---LLQSsvmdiYHTAQQA----KIDVRL-----TLNAHGIKRTGQPLLlsllvrnllDNAVRYS-----PQGSV- 373
Cdd:COG2972  298 TLEEeleLIKS-----YLEIQKLrfgdRLEVEIeideeLLDLLIPKLILQPLV---------ENAIEHGiepkeGGGTIr 363

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 374 VDITLNADS--FIVRDNGPGVTPEALARIGERFYRPPGqtatGSGLGLSIV-QRIAKLHGMN--VEFGNVEQGGFETKVS 448
Cdd:COG2972  364 ISIRKEGDRlvITVEDNGVGMPEEKLEKLLEELSSKGE----GRGIGLRNVrERLKLYYGEEygLEIESEPGEGTTVTIR 439


                 .
gi 446596024 449 W 449
Cdd:COG2972  440 I 440

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

362-442

5.05e-08

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 54.85 E-value: 5.05e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSPQGS----VVDITLNAD----SFIVRDNGPGVTPEALARIGERFYrpPGQTATGSGLGLSIVQRIAKLHGMNV 433
Cdd:COG3290  291 DNAIEAVEKLPeeerRVELSIRDDgdelVIEVEDSGPGIPEELLEKIFERGF--STKLGEGRGLGLALVKQIVEKYGGTI 368


                 ....*....
gi 446596024 434 EFGNVEQGG 442
Cdd:COG3290  369 EVESEEGEG 377

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

384-442

8.64e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 50.15 E-value: 8.64e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446596024 384 IVRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:cd16976   38 VVRDNGPGIAEEHLSRVFDPFFttKPVGK---GTGLGLSISYGIVEEHGGRLSVANEEGAG 95

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-447

2.13e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.94 E-value: 2.13e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAVRYSpqGSVVDITLNADS----FIVRDNGPGVTPEALARIGERFYRPPGQTAtGSGLGLSIVQRIAKLHGMNVEFGN 437
Cdd:cd16954   47 DNACKWC--LEFVEVTARQTDgglhLIVDDDGPGVPESQRSKIFQRGQRLDEQRP-GQGLGLAIAKEIVEQYGGELSLSD 123

                         90
                 ....*....|
gi 446596024 438 VEQGGFETKV 447
Cdd:cd16954  124 SPLGGARFEV 133

PRK13837

two-component system VirA-like sensor kinase;

240-430

3.52e-07

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 52.76 E-value: 3.52e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 240 FTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLdNLQDVAeipLEDLLQS 319
Cdd:PRK13837 453 LASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGER-NTKPFD---LSELVTE 528

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 320 SVMDI-YHTAQQAKIDVRLTlnAHGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDITLNADSFI-------------- 384
Cdd:PRK13837 529 IAPLLrVSLPPGVELDFDQD--QEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshgvlppgr 606

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446596024 385 -----VRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK13837 607 yvllrVSDTGAGIDEAVLPHIFEPFFT---TRAGGTGLGLATVHGIVSAHA 654

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

385-435

6.84e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.78 E-value: 6.84e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446596024 385 VRDNGPGVTPEALARIgerFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEF 435
Cdd:cd16918   48 VIDNGPGIPPDLQDTI---FYPMVSGRENGTGLGLAIAQNIVSQHGGVIEC 95

PRK15347

two component system sensor kinase;

154-430

1.02e-06

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 51.18 E-value: 1.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 154 DMALAIVAGQLiPW-LVALPIMLIIMMVLLGRELAplnklalalrmrdpdseKPL-------NATGVPSEVRPLVE---- 221
Cdd:PRK15347 289 NEALKPALQQL-PFaLLILVLLTSVLFLLLRRYLA-----------------KPLwrfvdiiNKTGPAALEPRLPEnrld 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 222 -------SLNQLFA---------------RTHA----------MMVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDP 269
Cdd:PRK15347 351 elgsiakAYNQLLDtlneqydtlenkvaeRTQAlaeakqraeqANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTA 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 270 QARKKALLQLHSGiDRATRLVDQLLTLSRLDSLD---NLQDVAEIPLEDllqSSVMDIYHTAQQAKIDVRLTLNAH---- 342
Cdd:PRK15347 431 EQMDLADTARQCT-LSLLAIINNLLDFSRIESGQmtlSLEETALLPLLD---QAMLTIQGPAQSKSLTLRTFVGAHvply 506

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 343 ----GIkRTGQplllslLVRNLLDNAVRYSPQGSVV-DITLNADS--FIVRDNGPGVTPEALARIGERFYRPpGQTATGS 415
Cdd:PRK15347 507 lhldSL-RLRQ------ILVNLLGNAVKFTETGGIRlRVKRHEQQlcFTVEDTGCGIDIQQQQQIFTPFYQA-DTHSQGT 578

                        330
                 ....*....|....*
gi 446596024 416 GLGLSIVQRIAKLHG 430
Cdd:PRK15347 579 GLGLTIASSLAKMMG 593

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

366-442

1.95e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 46.38 E-value: 1.95e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 366 RYSPQGSV-VDITLNAD---SFIVRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQG 441
Cdd:cd16944   23 RPSDVGEVrIRVEADQDgriVLIVCDNGKGFPREMRHRATEPYVT---TRPKGTGLGLAIVKKIMEEHGGRISLSNREAG 99


                 .
gi 446596024 442 G 442
Cdd:cd16944  100 G 100

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

252-449

3.02e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.46 E-value: 3.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 252 LTALKVQTEVAQ-LSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEipLEDLLQSsvmdiyhTAQQ 330
Cdd:COG4585   69 LSAIKLQLEAARrLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAA--LEELAER-------LLRA 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 331 AKIDVRLTLnahgikrTGQPLLLSLLVRNLL--------DNAVRYSpQGSVVDITLNAD----SFIVRDNGPGVTPEAla 398
Cdd:COG4585  140 AGIRVELDV-------DGDPDRLPPEVELALyrivqealTNALKHA-GATRVTVTLEVDdgelTLTVRDDGVGFDPEA-- 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446596024 399 rigerfyrppgqtATGSGLGL-SIVQRIAKLHGmNVEFGNVEQGGFETKVSW 449
Cdd:COG4585  210 -------------APGGGLGLrGMRERAEALGG-TLTIGSAPGGGTRVRATL 247

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

382-430

1.03e-05

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 44.68 E-value: 1.03e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446596024 382 SFIVRDNGPGVTPEALARIGERFY--RPPGQtatGSGLGLSIVQRIAKLHG 430
Cdd:cd16919   49 CLEVSDTGSGMPAEVLRRAFEPFFttKEVGK---GTGLGLSMVYGFVKQSG 96

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-442

3.43e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 42.66 E-value: 3.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 362 DNAV----RYSPQGSVVDITLNADS----FIVRDNGPGVTPEALARIGERFYRPPGQtaTGSGLGLSIVQRIAKLHGMNV 433
Cdd:cd16915   10 DNALdalaATGAPNKQVEVFLRDEGddlvIEVRDTGPGIAPELRDKVFERGVSTKGQ--GERGIGLALVRQSVERLGGSI 87


                 ....*....
gi 446596024 434 EFGNVEQGG 442
Cdd:cd16915   88 TVESEPGGG 96

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

362-426

4.06e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 42.89 E-value: 4.06e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446596024 362 DNAVRYSPQGSVVDITLNADS---FI-VRDNGPGVTPEALARIGERFY---RPPGQTATGSGLGLSIVQRIA 426
Cdd:cd16947   30 SNAIKYGSDGKFLGMTLREDEkhvYIdIWDKGKGISETEKDHVFERLYtleDSRNSAKQGNGLGLTITKRLA 101

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

385-442

5.03e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 42.38 E-value: 5.03e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446596024 385 VRDNGPGVTPEALARIGERFYRppgQTATGSGLGLSIVQRIAKLHGMNVEFGNVEQGG 442
Cdd:cd16920   42 VKDTGPGIAEEVAGQLFDPFYT---TKSEGLGMGLSICRSIIEAHGGRLSVESPAGGG 96

PRK09959

acid-sensing system histidine kinase EvgS;

214-427

1.33e-04

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 44.73 E-value: 1.33e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  214 SEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQL 293
Cdd:PRK09959  689 TETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEI 768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024  294 LTLSRLDSLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRL--TLNAHGIKRTgQPLLLSLLVRNLLDNAVRYSPQG 371
Cdd:PRK09959  769 LDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCssTFPDHYLVKI-DPQAFKQVLSNLLSNALKFTTEG 847

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446596024  372 SV--------VDITLNADSFIVRDNGPGVTPEALARIGERFYR-PPGQTATGSGLGLSIVQRIAK 427
Cdd:PRK09959  848 AVkittslghIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQtSAGRQQTGSGLGLMICKELIK 912

RsbW

COG2172

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

363-426

1.84e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.05 E-value: 1.84e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446596024 363 NAVRYSPQGS---VVDITLNADS----FIVRDNGPGVTPEALarigerfyRPPGQTATGSGLGLSIVQRIA 426
Cdd:COG2172   45 NAVRHAYGGDpdgPVEVELELDPdgleIEVRDEGPGFDPEDL--------PDPYSTLAEGGRGLFLIRRLM 107

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

363-430

3.22e-04

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 43.01 E-value: 3.22e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446596024 363 NAVRYSPQGSVVdITLNADS-----FIVRDNGPGVTPEALARIGERFY----RPPGQTATGSGLGLSIVQRIAKLHG 430
Cdd:PRK11091 409 NAVKFTQQGGVT-VRVRYEEgdmltFEVEDSGIGIPEDELDKIFAMYYqvkdSHGGKPATGTGIGLAVSKRLAQAMG 484

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

363-434

6.09e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 39.19 E-value: 6.09e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 363 NAVRYSPQGSvvDITLNADS------FIVRDNGPGVTPEALARIGERFY-----RppgQTATGSGLGLSIVQRIA-KL-H 429
Cdd:cd16948   16 NALKYSKQGG--KIEIYSETneqgvvLSIKDFGIGIPEEDLPRVFDKGFtgengR---NFQESTGMGLYLVKKLCdKLgH 90


                 ....*
gi 446596024 430 GMNVE 434
Cdd:cd16948   91 KIDVE 95

PRK13557

histidine kinase; Provisional

385-430

2.60e-03

histidine kinase; Provisional

Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 40.04 E-value: 2.60e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446596024 385 VRDNGPGVTPEALARIGERFYRPPGQtATGSGLGLSIVQRIAKLHG 430
Cdd:PRK13557 329 VTDTGSGMPPEILARVMDPFFTTKEE-GKGTGLGLSMVYGFAKQSG 373

HATPase_RsbW-like

cd16936

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...

363-426

4.78e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.

Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 36.09 E-value: 4.78e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446596024 363 NAVRY---SPQGSVVDITLNADS----FIVRDNGPGVTPEALarigerfyRPPGQTATGSGLGLSIVQRIA 426
Cdd:cd16936   11 NAVRHayrHDGPGPVRLELDLDPdrlrVEVTDSGPGFDPLRP--------ADPDAGLREGGRGLALIRALM 73

PRK10815

two-component system sensor histidine kinase PhoQ;

213-425

7.93e-03

two-component system sensor histidine kinase PhoQ;

Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 38.46 E-value: 7.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 213 PSEVRPLVESLNQLFARTHAMMVRERRFTSDAAHELRSPLTALkvQTEVAQLSDDDP----QARKKALLQ---------- 278
Cdd:PRK10815 242 PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVL--QSTLRSLRSGKQmsveQAEPIMLEQisrisqqigy 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446596024 279 -LHsgidRATRLVDQLLtLSRldsldNLQDVAeiPLEDLLQSSVMDIYhtaqQAKiDVRLTLN-AHGIKRTGQPLLLSLL 356
Cdd:PRK10815 320 yLH----RASMRSEHNL-LSR-----ELHSVA--PLLDNLTSALNKVY----QRK-GVNITLDiSPEITFVGEKNDFMEV 382

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446596024 357 VRNLLDNAVRYSPQgsVVDITL----NADSFIVRDNGPGVTPEALARIGERfyrppGQTA----TGSGLGLSIVQRI 425
Cdd:PRK10815 383 MGNVLDNACKYCLE--FVEISArqtdEHLHIVVEDDGPGIPESKRELIFDR-----GQRAdtlrPGQGLGLSVAREI 452

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01