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Conserved domains on  [gi|446597779|ref|WP_000675125|]
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MULTISPECIES: magnesium-translocating P-type ATPase [Acinetobacter]

Protein Classification

magnesium-translocating P-type ATPase( domain architecture ID 11484758)

magnesium-translocating P-type ATPase mediates magnesium influx to the cytosol

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
1-918 0e+00

magnesium-transporting P-type ATPase MgtA;


:

Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 1793.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   1 MKFWQRLFTSFLqRFHLMRFFGRNRSFkeLHQSSYAQEISKNLSKRLLNASRAQTNDLLKQFDTHLTGLTEEQAHTQQMT 80
Cdd:PRK10517   3 KTMLKELFTRLL-RHLPSRLVHRDPLP--GAQQTVNTAVPPSLSARCLKAAVMPEEELWKTFDTHPEGLNEAEVESAREQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  81 VGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSN 160
Cdd:PRK10517  80 HGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 161 TATVLRHQVSAEDlelmherygidtknqtTHQFEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPV 240
Cdd:PRK10517 160 TATVLRVINDKGE----------------NGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPV 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 241 EKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVM 320
Cdd:PRK10517 224 EKFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVM 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 321 APVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLT 400
Cdd:PRK10517 304 APVVLLINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLT 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 401 QDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLLDVAVLEAVDDQIKIQKL-RYKKLDEVPFDFDRRRMSVVVQTP 479
Cdd:PRK10517 384 QDKIVLENHTDISGKTSERVLHSAWLNSHYQTGLKNLLDTAVLEGVDEESARSLAsRWQKIDEIPFDFERRRMSVVVAEN 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 480 QQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIG 559
Cdd:PRK10517 464 TEHHQLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLILEG 543
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 560 YITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSP 639
Cdd:PRK10517 544 YIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGEVLIGSDIETLSDDELANLAERTTLFARLTP 623
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 640 VHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYI 719
Cdd:PRK10517 624 MHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI 703
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 720 KMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELIAKPQRWQPEEVGRFMVVFGPISSIF 799
Cdd:PRK10517 704 KMTASSNFGNVFSVLVASAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFGPISSIF 783
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 800 DMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLIVHMIRTAQIPFIQSRAATPLLIMTAVIMCIGIFLPMGPLASY 879
Cdd:PRK10517 784 DILTFCLMWWVFHANTPETQTLFQSGWFVVGLLSQTLIVHMIRTRRIPFIQSRAAWPLMIMTLIVMAVGIALPFSPLASY 863
                        890       900       910
                 ....*....|....*....|....*....|....*....
gi 446597779 880 LKLQALPLSYFLYLPVILGAYMCVTQWVKKIYIRRYGWQ 918
Cdd:PRK10517 864 LQLQALPLSYFPWLVAILAGYMTLTQLVKGFYSRRYGWQ 902
 
Name Accession Description Interval E-value
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
1-918 0e+00

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 1793.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   1 MKFWQRLFTSFLqRFHLMRFFGRNRSFkeLHQSSYAQEISKNLSKRLLNASRAQTNDLLKQFDTHLTGLTEEQAHTQQMT 80
Cdd:PRK10517   3 KTMLKELFTRLL-RHLPSRLVHRDPLP--GAQQTVNTAVPPSLSARCLKAAVMPEEELWKTFDTHPEGLNEAEVESAREQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  81 VGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSN 160
Cdd:PRK10517  80 HGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 161 TATVLRHQVSAEDlelmherygidtknqtTHQFEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPV 240
Cdd:PRK10517 160 TATVLRVINDKGE----------------NGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPV 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 241 EKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVM 320
Cdd:PRK10517 224 EKFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVM 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 321 APVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLT 400
Cdd:PRK10517 304 APVVLLINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLT 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 401 QDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLLDVAVLEAVDDQIKIQKL-RYKKLDEVPFDFDRRRMSVVVQTP 479
Cdd:PRK10517 384 QDKIVLENHTDISGKTSERVLHSAWLNSHYQTGLKNLLDTAVLEGVDEESARSLAsRWQKIDEIPFDFERRRMSVVVAEN 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 480 QQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIG 559
Cdd:PRK10517 464 TEHHQLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLILEG 543
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 560 YITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSP 639
Cdd:PRK10517 544 YIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGEVLIGSDIETLSDDELANLAERTTLFARLTP 623
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 640 VHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYI 719
Cdd:PRK10517 624 MHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI 703
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 720 KMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELIAKPQRWQPEEVGRFMVVFGPISSIF 799
Cdd:PRK10517 704 KMTASSNFGNVFSVLVASAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFGPISSIF 783
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 800 DMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLIVHMIRTAQIPFIQSRAATPLLIMTAVIMCIGIFLPMGPLASY 879
Cdd:PRK10517 784 DILTFCLMWWVFHANTPETQTLFQSGWFVVGLLSQTLIVHMIRTRRIPFIQSRAAWPLMIMTLIVMAVGIALPFSPLASY 863
                        890       900       910
                 ....*....|....*....|....*....|....*....
gi 446597779 880 LKLQALPLSYFLYLPVILGAYMCVTQWVKKIYIRRYGWQ 918
Cdd:PRK10517 864 LQLQALPLSYFPWLVAILAGYMTLTQLVKGFYSRRYGWQ 902
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
68-848 0e+00

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 1202.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTD--------DLTGSTIISVMVILSTLL 139
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDvllapgefDLVGALIILLMVLISGLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 140 RYWQEAKSNQAADALKVMVSNTATVLRHQVSAEdlelmherygidtknqtthqfEIPIQYLVPGDVILLSAGDMIPADCR 219
Cdd:cd02077   81 DFIQEIRSLKAAEKLKKMVKNTATVIRDGSKYM---------------------EIPIDELVPGDIVYLSAGDMIPADVR 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 220 ILSAKDLFVSQAAMTGESMPVEKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTaTDRST 299
Cdd:cd02077  140 IIQSKDLFVSQSSLTGESEPVEKHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSIT-EKRPE 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 300 TAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRL 379
Cdd:cd02077  219 TSFDKGINKVSKLLIRFMLVMVPVVFLINGLTKGDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNL 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 380 DAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLLDVAVLEAVDD-QIKIQKLRYK 458
Cdd:cd02077  299 NAIQNFGAMDILCTDKTGTLTQDKIVLERHLDVNGKESERVLRLAYLNSYFQTGLKNLLDKAIIDHAEEaNANGLIQDYT 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 459 KLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYR 538
Cdd:cd02077  379 KIDEIPFDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVEELNREGLRVLAIAYK 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 539 EFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIET 618
Cdd:cd02077  459 KLPAPEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGLDINRVLTGSEIEA 538
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 619 LTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSL 698
Cdd:cd02077  539 LSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEAADIILLEKDL 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 699 MVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELIAKPQ 778
Cdd:cd02077  619 MVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASAFLPFLPMLPIQLLLQNLLYDFSQLAIPFDNVDEEFLKKPQ 698
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 779 RWQPEEVGRFMVVFGPISSIFDMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLIVHMIRTAQIPF 848
Cdd:cd02077  699 KWDIKNIGRFMIWIGPISSIFDILTFLVMWFVFKANTAASQALFQTGWFIEGLLTQTLVVHMIRTEKIPF 768
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
39-918 0e+00

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 1181.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   39 ISKNLSKRLLNASRAQTNDLLKQFDTHLTGLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAF 118
Cdd:TIGR01524   4 HVKKQGNNLLKESQMGKETLLRKLGVHETGLTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  119 FTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRhqvsaedlelmherygIDTKNQTTHQFEIPIQ 198
Cdd:TIGR01524  84 LTDDLEATVIIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLR----------------VINENGNGSMDEVPID 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  199 YLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLS 278
Cdd:TIGR01524 148 ALVPGDLIELAAGDIIPADARVISARDLFINQSALTGESLPVEKFVEDKRARDPEILERENLCFMGTNVLSGHAQAVVLA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  279 TGIQTYFGALAHRVTAtDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIV 358
Cdd:TIGR01524 228 TGSSTWFGSLAIAATE-RRGQTAFDKGVKSVSKLLIRFMLVMVPVVLMINGLMKGDWLEAFLFALAVAVGLTPEMLPMIV 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  359 TSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLL 438
Cdd:TIGR01524 307 SSNLAKGAINMSKKKVIVKELSAIQNFGAMDILCTDKTGTLTQDKIELEKHIDSSGETSERVLKMAWLNSYFQTGWKNVL 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  439 DVAVLEAVDDQIKIQ-KLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVA 517
Cdd:TIGR01524 387 DHAVLAKLDESAARQtASRWKKVDEIPFDFDRRRLSVVVENRAEVTRLICKGAVEEMLTVCTHKRFGGAVVTLSESEKSE 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  518 IEALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQ 597
Cdd:TIGR01524 467 LQDMTAEMNRQGIRVIAVATKTLKVGEADFTKTDEEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTA 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  598 KVCREISLNYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGIS 677
Cdd:TIGR01524 547 RICQEVGIDANDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKADVGIS 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  678 VDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLY 757
Cdd:TIGR01524 627 VDTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASAFIPFLPMLSLHLLIQNLLY 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  758 DVSQIVIPFDNVDEELIAKPQRWQPEEVGRFMVVFGPISSIFDMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLI 837
Cdd:TIGR01524 707 DFSQLTLPWDKMDREFLKKPHQWEQKGMGRFMLCIGPVSSIFDIATFLLMWFVFSANTVEEQALFQSGWFVVGLLSQTLV 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  838 VHMIRTAQIPFIQSRAATPLLIMTAVIMCIGIFLPMGPLASYLKLQALPLSYFLYLPVILGAYMCVTQWVKKIYIRRYGW 917
Cdd:TIGR01524 787 VHMIRTEKIPFIQSRAAAPVMIATLLVMALGIIIPFSPLGHSIGLVSLPLSYFPWLIAILVGYMATMQLVKTFYIRRFGE 866

                  .
gi 446597779  918 Q 918
Cdd:TIGR01524 867 W 867
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
55-916 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 951.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  55 TNDLLKQFDTHLTGLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVI 134
Cdd:COG0474   13 AEEVLAELGTSEEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLGDWVDAIVILAVVL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 135 LSTLLRYWQEAKSNQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDVILLSAGDMI 214
Cdd:COG0474   93 LNAIIGFVQEYRAEKALEALKKLLAPTARVLR-----------------DGKWV-----EIPAEELVPGDIVLLEAGDRV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 215 PADCRILSAKDLFVSQAAMTGESMPVEKFPLQKNlEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTA 294
Cdd:COG0474  151 PADLRLLEAKDLQVDESALTGESVPVEKSADPLP-EDAPLGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQE 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 295 TDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKV 374
Cdd:COG0474  230 AEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNA 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 375 IVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHID------VQGGKS---DFVLMQAFLNSYYQ----TGLKNLLDVA 441
Cdd:COG0474  310 IVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTgggtyeVTGEFDpalEELLRAAALCSDAQleeeTGLGDPTEGA 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 442 VLEAVDDQ-IKIQKLR--YKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAI 518
Cdd:COG0474  390 LLVAAAKAgLDVEELRkeYPRVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEI 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 519 EALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQK 598
Cdd:COG0474  470 LEAVEELAAQGLRVLAVAYKELPADPELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARA 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 599 VCREISL--NYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINdaaairaadiGI 676
Cdd:COG0474  550 IARQLGLgdDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNdapalkaadiGI 629
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 677 SVD-TAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAF-IPfLPMLPIHLLIQN 754
Cdd:COG0474  630 AMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLgLP-LPLTPIQILWIN 708
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 755 LLYDV-SQIVIPFDNVDEELIAKPQRWQPE-----EVGRFMVVFGPISSIFDMITFGLMWfvfsaNTPEHQTLFQSGWFM 828
Cdd:COG0474  709 LVTDGlPALALGFEPVEPDVMKRPPRWPDEpilsrFLLLRILLLGLLIAIFTLLTFALAL-----ARGASLALARTMAFT 783
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 829 VGLLTQTLIVHMIRTAQIPFIQSR--AATPLLIMTAVIMCIGIFLPMGP-LASYLKLQALPLSYFLYLPVILGAYMCVTQ 905
Cdd:COG0474  784 TLVLSQLFNVFNCRSERRSFFKSGlfPNRPLLLAVLLSLLLQLLLIYVPpLQALFGTVPLPLSDWLLILGLALLYLLLVE 863
                        890
                 ....*....|.
gi 446597779 906 WVkKIYIRRYG 916
Cdd:COG0474  864 LV-KLLRRRFG 873
E1-E2_ATPase pfam00122
E1-E2 ATPase;
194-372 7.84e-41

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 148.10  E-value: 7.84e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQ 273
Cdd:pfam00122  17 EVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEKKK-------------GDMVYSGTVVVSGSAK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  274 AVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEM 353
Cdd:pfam00122  83 AVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALLRALAVLVAACPCA 162
                         170
                  ....*....|....*....
gi 446597779  354 LPMIVTSTLAKGAVFLSKK 372
Cdd:pfam00122 163 LPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
56-107 5.37e-05

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 42.18  E-value: 5.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 446597779    56 NDLLKQFDTHLT-GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFN 107
Cdd:smart00831  10 EEVLERLQTDLEkGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLI 62
 
Name Accession Description Interval E-value
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
1-918 0e+00

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 1793.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   1 MKFWQRLFTSFLqRFHLMRFFGRNRSFkeLHQSSYAQEISKNLSKRLLNASRAQTNDLLKQFDTHLTGLTEEQAHTQQMT 80
Cdd:PRK10517   3 KTMLKELFTRLL-RHLPSRLVHRDPLP--GAQQTVNTAVPPSLSARCLKAAVMPEEELWKTFDTHPEGLNEAEVESAREQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  81 VGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSN 160
Cdd:PRK10517  80 HGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 161 TATVLRHQVSAEDlelmherygidtknqtTHQFEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPV 240
Cdd:PRK10517 160 TATVLRVINDKGE----------------NGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPV 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 241 EKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVM 320
Cdd:PRK10517 224 EKFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVM 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 321 APVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLT 400
Cdd:PRK10517 304 APVVLLINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLT 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 401 QDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLLDVAVLEAVDDQIKIQKL-RYKKLDEVPFDFDRRRMSVVVQTP 479
Cdd:PRK10517 384 QDKIVLENHTDISGKTSERVLHSAWLNSHYQTGLKNLLDTAVLEGVDEESARSLAsRWQKIDEIPFDFERRRMSVVVAEN 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 480 QQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIG 559
Cdd:PRK10517 464 TEHHQLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLILEG 543
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 560 YITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSP 639
Cdd:PRK10517 544 YIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGEVLIGSDIETLSDDELANLAERTTLFARLTP 623
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 640 VHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYI 719
Cdd:PRK10517 624 MHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI 703
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 720 KMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELIAKPQRWQPEEVGRFMVVFGPISSIF 799
Cdd:PRK10517 704 KMTASSNFGNVFSVLVASAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFGPISSIF 783
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 800 DMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLIVHMIRTAQIPFIQSRAATPLLIMTAVIMCIGIFLPMGPLASY 879
Cdd:PRK10517 784 DILTFCLMWWVFHANTPETQTLFQSGWFVVGLLSQTLIVHMIRTRRIPFIQSRAAWPLMIMTLIVMAVGIALPFSPLASY 863
                        890       900       910
                 ....*....|....*....|....*....|....*....
gi 446597779 880 LKLQALPLSYFLYLPVILGAYMCVTQWVKKIYIRRYGWQ 918
Cdd:PRK10517 864 LQLQALPLSYFPWLVAILAGYMTLTQLVKGFYSRRYGWQ 902
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
40-917 0e+00

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 1238.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  40 SKNLSKRLLNASRAQTNDLLKQFDTHLTGLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFF 119
Cdd:PRK15122  17 NHKKSMRIAREAANSLEETLANLNTHRQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 120 TD-----------DLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRHQVSAEDLELMherygidtknq 188
Cdd:PRK15122  97 TDywlplrrgeetDLTGVIIILTMVLLSGLLRFWQEFRSNKAAEALKAMVRTTATVLRRGHAGAEPVRR----------- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 189 tthqfEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKF-----PLQKNLE-----ETSALELD 258
Cdd:PRK15122 166 -----EIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVEKYdtlgaVAGKSADaladdEGSLLDLP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 259 NIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATdRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEA 338
Cdd:PRK15122 241 NICFMGTNVVSGTATAVVVATGSRTYFGSLAKSIVGT-RAQTAFDRGVNSVSWLLIRFMLVMVPVVLLINGFTKGDWLEA 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 339 FLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSD 418
Cdd:PRK15122 320 LLFALAVAVGLTPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHLDVSGRKDE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 419 FVLMQAFLNSYYQTGLKNLLDVAVLEAVDDQIKIQKL-RYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKV 497
Cdd:PRK15122 400 RVLQLAWLNSFHQSGMKNLMDQAVVAFAEGNPEIVKPaGYRKVDELPFDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAV 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 498 CRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQEN--YSVVDESDLILIGYITFLDPPKESAKEAV 575
Cdd:PRK15122 480 ATHVRDGDTVRPLDEARRERLLALAEAYNADGFRVLLVATREIPGGESRaqYSTADERDLVIRGFLTFLDPPKESAAPAI 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 576 QSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHV 655
Cdd:PRK15122 560 AALRENGVAVKVLTGDNPIVTAKICREVGLEPGEPLLGTEIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANGHT 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 656 VGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLI 735
Cdd:PRK15122 640 VGFLGDGINDAPALRDADVGISVDSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYLNMTASSNFGNVFSVLV 719
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 736 ASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELIAKPQRWQPEEVGRFMVVFGPISSIFDMITFGLMWFVFSANT 815
Cdd:PRK15122 720 ASAFIPFLPMLAIHLLLQNLMYDISQLSLPWDKMDKEFLRKPRKWDAKNIGRFMLWIGPTSSIFDITTFALMWFVFAANS 799
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 816 PEHQTLFQSGWFMVGLLTQTLIVHMIRTAQIPFIQSRAATPLLIMTAVIMCIGIFLPMGPLASYLKLQALPLSYFLYLPV 895
Cdd:PRK15122 800 VEMQALFQSGWFIEGLLSQTLVVHMLRTQKIPFIQSTAALPVLLTTGLIMAIGIYIPFSPLGAMVGLEPLPWSYFPWLAA 879
                        890       900
                 ....*....|....*....|...
gi 446597779 896 ILGAYMCVTQWVKKIYIRRYG-W 917
Cdd:PRK15122 880 TLLGYCLVAQGMKRFYIRRFGqW 902
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
68-848 0e+00

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 1202.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTD--------DLTGSTIISVMVILSTLL 139
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDvllapgefDLVGALIILLMVLISGLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 140 RYWQEAKSNQAADALKVMVSNTATVLRHQVSAEdlelmherygidtknqtthqfEIPIQYLVPGDVILLSAGDMIPADCR 219
Cdd:cd02077   81 DFIQEIRSLKAAEKLKKMVKNTATVIRDGSKYM---------------------EIPIDELVPGDIVYLSAGDMIPADVR 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 220 ILSAKDLFVSQAAMTGESMPVEKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTaTDRST 299
Cdd:cd02077  140 IIQSKDLFVSQSSLTGESEPVEKHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSIT-EKRPE 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 300 TAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRL 379
Cdd:cd02077  219 TSFDKGINKVSKLLIRFMLVMVPVVFLINGLTKGDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNL 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 380 DAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLLDVAVLEAVDD-QIKIQKLRYK 458
Cdd:cd02077  299 NAIQNFGAMDILCTDKTGTLTQDKIVLERHLDVNGKESERVLRLAYLNSYFQTGLKNLLDKAIIDHAEEaNANGLIQDYT 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 459 KLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYR 538
Cdd:cd02077  379 KIDEIPFDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVEELNREGLRVLAIAYK 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 539 EFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIET 618
Cdd:cd02077  459 KLPAPEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGLDINRVLTGSEIEA 538
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 619 LTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSL 698
Cdd:cd02077  539 LSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEAADIILLEKDL 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 699 MVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELIAKPQ 778
Cdd:cd02077  619 MVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASAFLPFLPMLPIQLLLQNLLYDFSQLAIPFDNVDEEFLKKPQ 698
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 779 RWQPEEVGRFMVVFGPISSIFDMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLIVHMIRTAQIPF 848
Cdd:cd02077  699 KWDIKNIGRFMIWIGPISSIFDILTFLVMWFVFKANTAASQALFQTGWFIEGLLTQTLVVHMIRTEKIPF 768
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
39-918 0e+00

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 1181.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   39 ISKNLSKRLLNASRAQTNDLLKQFDTHLTGLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAF 118
Cdd:TIGR01524   4 HVKKQGNNLLKESQMGKETLLRKLGVHETGLTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  119 FTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRhqvsaedlelmherygIDTKNQTTHQFEIPIQ 198
Cdd:TIGR01524  84 LTDDLEATVIIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLR----------------VINENGNGSMDEVPID 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  199 YLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLS 278
Cdd:TIGR01524 148 ALVPGDLIELAAGDIIPADARVISARDLFINQSALTGESLPVEKFVEDKRARDPEILERENLCFMGTNVLSGHAQAVVLA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  279 TGIQTYFGALAHRVTAtDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIV 358
Cdd:TIGR01524 228 TGSSTWFGSLAIAATE-RRGQTAFDKGVKSVSKLLIRFMLVMVPVVLMINGLMKGDWLEAFLFALAVAVGLTPEMLPMIV 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  359 TSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNLL 438
Cdd:TIGR01524 307 SSNLAKGAINMSKKKVIVKELSAIQNFGAMDILCTDKTGTLTQDKIELEKHIDSSGETSERVLKMAWLNSYFQTGWKNVL 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  439 DVAVLEAVDDQIKIQ-KLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVA 517
Cdd:TIGR01524 387 DHAVLAKLDESAARQtASRWKKVDEIPFDFDRRRLSVVVENRAEVTRLICKGAVEEMLTVCTHKRFGGAVVTLSESEKSE 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  518 IEALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQ 597
Cdd:TIGR01524 467 LQDMTAEMNRQGIRVIAVATKTLKVGEADFTKTDEEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTA 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  598 KVCREISLNYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGIS 677
Cdd:TIGR01524 547 RICQEVGIDANDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKADVGIS 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  678 VDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLY 757
Cdd:TIGR01524 627 VDTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASAFIPFLPMLSLHLLIQNLLY 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  758 DVSQIVIPFDNVDEELIAKPQRWQPEEVGRFMVVFGPISSIFDMITFGLMWFVFSANTPEHQTLFQSGWFMVGLLTQTLI 837
Cdd:TIGR01524 707 DFSQLTLPWDKMDREFLKKPHQWEQKGMGRFMLCIGPVSSIFDIATFLLMWFVFSANTVEEQALFQSGWFVVGLLSQTLV 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  838 VHMIRTAQIPFIQSRAATPLLIMTAVIMCIGIFLPMGPLASYLKLQALPLSYFLYLPVILGAYMCVTQWVKKIYIRRYGW 917
Cdd:TIGR01524 787 VHMIRTEKIPFIQSRAAAPVMIATLLVMALGIIIPFSPLGHSIGLVSLPLSYFPWLIAILVGYMATMQLVKTFYIRRFGE 866

                  .
gi 446597779  918 Q 918
Cdd:TIGR01524 867 W 867
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
55-916 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 951.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  55 TNDLLKQFDTHLTGLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVI 134
Cdd:COG0474   13 AEEVLAELGTSEEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLGDWVDAIVILAVVL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 135 LSTLLRYWQEAKSNQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDVILLSAGDMI 214
Cdd:COG0474   93 LNAIIGFVQEYRAEKALEALKKLLAPTARVLR-----------------DGKWV-----EIPAEELVPGDIVLLEAGDRV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 215 PADCRILSAKDLFVSQAAMTGESMPVEKFPLQKNlEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTA 294
Cdd:COG0474  151 PADLRLLEAKDLQVDESALTGESVPVEKSADPLP-EDAPLGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQE 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 295 TDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKV 374
Cdd:COG0474  230 AEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNA 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 375 IVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHID------VQGGKS---DFVLMQAFLNSYYQ----TGLKNLLDVA 441
Cdd:COG0474  310 IVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTgggtyeVTGEFDpalEELLRAAALCSDAQleeeTGLGDPTEGA 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 442 VLEAVDDQ-IKIQKLR--YKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAI 518
Cdd:COG0474  390 LLVAAAKAgLDVEELRkeYPRVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEI 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 519 EALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQK 598
Cdd:COG0474  470 LEAVEELAAQGLRVLAVAYKELPADPELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARA 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 599 VCREISL--NYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINdaaairaadiGI 676
Cdd:COG0474  550 IARQLGLgdDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNdapalkaadiGI 629
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 677 SVD-TAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAF-IPfLPMLPIHLLIQN 754
Cdd:COG0474  630 AMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLgLP-LPLTPIQILWIN 708
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 755 LLYDV-SQIVIPFDNVDEELIAKPQRWQPE-----EVGRFMVVFGPISSIFDMITFGLMWfvfsaNTPEHQTLFQSGWFM 828
Cdd:COG0474  709 LVTDGlPALALGFEPVEPDVMKRPPRWPDEpilsrFLLLRILLLGLLIAIFTLLTFALAL-----ARGASLALARTMAFT 783
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 829 VGLLTQTLIVHMIRTAQIPFIQSR--AATPLLIMTAVIMCIGIFLPMGP-LASYLKLQALPLSYFLYLPVILGAYMCVTQ 905
Cdd:COG0474  784 TLVLSQLFNVFNCRSERRSFFKSGlfPNRPLLLAVLLSLLLQLLLIYVPpLQALFGTVPLPLSDWLLILGLALLYLLLVE 863
                        890
                 ....*....|.
gi 446597779 906 WVkKIYIRRYG 916
Cdd:COG0474  864 LV-KLLRRRFG 873
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
68-758 2.42e-151

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 462.08  E-value: 2.42e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKS 147
Cdd:cd02089    1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGEYVDAIVIIAIVILNAVLGFVQEYKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 148 NQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLF 227
Cdd:cd02089   81 EKALAALKKMSAPTAKVLR-----------------DGKKQ-----EIPARELVPGDIVLLEAGDYVPADGRLIESASLR 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 228 VSQAAMTGESMPVEKFPLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVN 307
Cdd:cd02089  139 VEESSLTGESEPVEKDADTLLEEDVPLGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLD 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 308 KVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGA 387
Cdd:cd02089  219 QLGKRLAIAALIICALVFALGLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGS 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 388 MDVLCTDKTGTLTQDKIFLsQHIDVQGGKSDfvlmQAFLNSYYQTGLknlldvavleavdDQIKIQKlRYKKLDEVPFDF 467
Cdd:cd02089  299 VSVICSDKTGTLTQNKMTV-EKIYTIGDPTE----TALIRAARKAGL-------------DKEELEK-KYPRIAEIPFDS 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 468 DRRRMSVVVQTPQQKArMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENY 547
Cdd:cd02089  360 ERKLMTTVHKDAGKYI-VFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSEEALRVLAVAYKPLDEDPTES 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 548 SVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL--NYDQVLLGGVIETLTDQQLK 625
Cdd:cd02089  439 SEDLENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGIleDGDKALTGEELDKMSDEELE 518
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 626 RAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVD-TAVDIAKESADLILLEKSLMVLEKG 704
Cdd:cd02089  519 KKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGiTGTDVAKEAADMILTDDNFATIVAA 598
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446597779 705 VIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYD 758
Cdd:cd02089  599 VEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTD 652
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
128-747 9.53e-127

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 393.61  E-value: 9.53e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  128 IISVMVILSTLLRYWQEAKSNQAADALKVMVSN--TATVLRHQVSaedlelmherygidtknqtthqfEIPIQYLVPGDV 205
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNtaTVLVLRNGWK-----------------------EISSKDLVPGDV 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  206 ILLSAGDMIPADCRILSAkDLFVSQAAMTGESMPVEKFPLQKNleetsaleldNIVFMGTNIVSGSAQAVVLSTGIQTYF 285
Cdd:TIGR01494  58 VLVKSGDTVPADGVLLSG-SAFVDESSLTGESLPVLKTALPDG----------DAVFAGTINFGGTLIVKVTATGILTTV 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  286 GALAHRVTATDRSTTAFQMGVNKVS---WLLIRFMLVMAPVVLFINGF-TKGDWAEAFLFALSVAVGLTPEMLPMIVTST 361
Cdd:TIGR01494 127 GKIAVVVYTGFSTKTPLQSKADKFEnfiFILFLLLLALAVFLLLPIGGwDGNSIYKAILRALAVLVIAIPCALPLAVSVA 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  362 LAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQA-FLNSYYQTGlkNLLDV 440
Cdd:TIGR01494 207 LAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEEASLALALlAASLEYLSG--HPLER 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  441 AVLEAVDDQIKIQ--KLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCryvevngKVEPLTKQCevai 518
Cdd:TIGR01494 285 AIVKSAEGVIKSDeiNVEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERC-------NNENDYDEK---- 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  519 ealTQRYNRDGLRVVAVAYREFknhqenysvvdESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQK 598
Cdd:TIGR01494 354 ---VDEYARQGLRVLAFASKKL-----------PDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKA 419
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  599 VCREISLNYdqvllggvietltdqqlkraveqyhiFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISV 678
Cdd:TIGR01494 420 IAKELGIDV--------------------------FARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAM 473
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446597779  679 DTAvDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLP 747
Cdd:TIGR01494 474 GSG-DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVIILLPPLLA 541
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
68-793 4.98e-123

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 392.40  E-value: 4.98e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKS 147
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFGVVLINAIIGYIQEGKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 148 NQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQTthqfeIPIQYLVPGDVILLSAGDMIPADCRILSAKDLF 227
Cdd:cd02080   81 EKALAAIKNMLSPEATVLR-----------------DGKKLT-----IDAEELVPGDIVLLEAGDKVPADLRLIEARNLQ 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 228 VSQAAMTGESMPVEKfpLQKNLEETSAL-ELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGV 306
Cdd:cd02080  139 IDESALTGESVPVEK--QEGPLEEDTPLgDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQI 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 307 NKVS-WLLIRFMLVMApvVLFINGFTKGD--WAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQ 383
Cdd:cd02080  217 AKFSkALLIVILVLAA--LTFVFGLLRGDysLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVE 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 384 NFGAMDVLCTDKTGTLTQDK-----IFL----------SQHIDVQGGKSDfvlmQAFLNSYYQTGLKNLLDVAvleavdd 448
Cdd:cd02080  295 TLGSVTVICSDKTGTLTRNEmtvqaIVTlcndaqlhqeDGHWKITGDPTE----GALLVLAAKAGLDPDRLAS------- 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 449 qikiqklRYKKLDEVPFDFDRRRMSVVvqTPQQKARMI-TKGAVEEMLKVCRYVEVNGKVEPLTKQcevAIEALTQRYNR 527
Cdd:cd02080  364 -------SYPRVDKIPFDSAYRYMATL--HRDDGQRVIyVKGAPERLLDMCDQELLDGGVSPLDRA---YWEAEAEDLAK 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 528 DGLRVVAVAYREFKNHQENYSVVD-ESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLN 606
Cdd:cd02080  432 QGLRVLAFAYREVDSEVEEIDHADlEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLG 511
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 607 YDQ-VLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVD-TAVDI 684
Cdd:cd02080  512 DGKkVLTGAELDALDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGiKGTEV 591
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 685 AKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYDVS-QIV 763
Cdd:cd02080  592 AKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITlGLA 671
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|..
gi 446597779 764 IPFD------------NVDEELIAKPQRWQPEEVGRFMVVFG 793
Cdd:cd02080  672 LAFEpaepgimkrpprDPSEPLLSRELIWRILLVSLLMLGGA 713
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
68-811 9.20e-111

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 358.85  E-value: 9.20e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYcYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKS 147
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNELPEKKENPILKFLSF-FWGPIPWMLEAAAILAAALGDWVDFAIILLLLLINAGIGFIEERQA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 148 NQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLF 227
Cdd:cd02076   80 GNAVAALKKSLAPKARVLR-----------------DGQWQ-----EIDAKELVPGDIVSLKIGDIVPADARLLTGDALQ 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 228 VSQAAMTGESMPVEKFPLQknleetsaleldnIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRsTTAFQMGVN 307
Cdd:cd02076  138 VDQSALTGESLPVTKHPGD-------------EAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEE-QGHLQKVLN 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 308 KVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGA 387
Cdd:cd02076  204 KIGNFLILLALILVLIIVIVALYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAG 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 388 MDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAFLNSyyQTGLKNLLDVAVLEAVDDqIKIQKLRYKKLDEVPFDF 467
Cdd:cd02076  284 VDILCSDKTGTLTLNKLSLDEPYSLEGDGKDELLLLAALAS--DTENPDAIDTAILNALDD-YKPDLAGYKQLKFTPFDP 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 468 DRRRMSVVVQTPQQKARMITKGAVEEMLKVCryvevnGKVEPLTKQCEVAIEALTQRynrdGLRVVAVAyrefknhqeny 547
Cdd:cd02076  361 VDKRTEATVEDPDGERFKVTKGAPQVILELV------GNDEAIRQAVEEKIDELASR----GYRSLGVA----------- 419
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 548 SVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL-----NYDQVLLGGVIETLTDQ 622
Cdd:cd02076  420 RKEDGGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMgtnilSAERLKLGGGGGGMPGS 499
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 623 QLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLE 702
Cdd:cd02076  500 ELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATDAARAAADIVLTAPGLSVII 579
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 703 KGVIEGRRTFANMLKYI--KMTASSNFgnVFSVLIASAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEEliAKPQRW 780
Cdd:cd02076  580 DAIKTSRQIFQRMKSYViyRIAETLRI--LVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYDNVPPS--PRPVRW 655
                        730       740       750
                 ....*....|....*....|....*....|.
gi 446597779 781 QPEEVGRFMVVFGPISSIfdmITFGLMWFVF 811
Cdd:cd02076  656 NMPELLGIATVLGVVLTI---SSFLLLWLLD 683
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
68-811 5.50e-108

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 350.86  E-value: 5.50e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYrNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKS 147
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELPEKKVSPLLKFLGFFW-NPLSWVMEAAAIIAIALENWVDFVIILGLLLLNATIGFIEENKA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  148 NQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLF 227
Cdd:TIGR01647  80 GNAVEALKQSLAPKARVLR-----------------DGKWQ-----EIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQ 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  228 VSQAAMTGESMPVEKfplqknleetsalELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVN 307
Cdd:TIGR01647 138 VDQAALTGESLPVTK-------------KTGDIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILS 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  308 KVSWLLIRFMLVMAPVVLFIN-GFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFG 386
Cdd:TIGR01647 205 KIGLFLIVLIGVLVLIELVVLfFGRGESFREGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELA 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  387 AMDVLCTDKTGTLTQDKIFLSQHIDVQGGKS-DFVLMQAFLNSyyQTGLKNLLDVAVLEAVDDqIKIQKLRYKKLDEVPF 465
Cdd:TIGR01647 285 GMDILCSDKTGTLTLNKLSIDEILPFFNGFDkDDVLLYAALAS--REEDQDAIDTAVLGSAKD-LKEARDGYKVLEFVPF 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  466 D-FDRRRMSVVVQTPQQKARMITKGAVEEMLKVC-RYVEVNGKVEPLtkqcevaIEALTQRynrdGLRVVAVAYREFKNH 543
Cdd:TIGR01647 362 DpVDKRTEATVEDPETGKRFKVTKGAPQVILDLCdNKKEIEEKVEEK-------VDELASR----GYRALGVARTDEEGR 430
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  544 QEnysvvdesdliLIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYD----QVLLGGVIETL 619
Cdd:TIGR01647 431 WH-----------FLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiytaDVLLKGDNRDD 499
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  620 TDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLM 699
Cdd:TIGR01647 500 LPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAVAGATDAARSAADIVLTEPGLS 579
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  700 VLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIaSAFIPFLPMLPIHLLIQNLLYDVSQIVIPFDNVDEELiaKPQR 779
Cdd:TIGR01647 580 VIVDAILESRKIFQRMKSYVIYRIAETIRIVFFFGL-LILILNFYFPPIMVVIIAILNDGTIMTIAYDNVKPSK--LPQR 656
                         730       740       750
                  ....*....|....*....|....*....|..
gi 446597779  780 WQPEEVGRFMVVFGPISSIfdmITFGLMWFVF 811
Cdd:TIGR01647 657 WNLREVFTMSTVLGIYLVI---STFLLLAIAL 685
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
119-759 1.67e-101

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 330.15  E-value: 1.67e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 119 FTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRHQVSAEDlelmherygidtknqtthqfEIPIQ 198
Cdd:cd07539   53 STGGGVDAVLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRAPAGRTQ--------------------TVPAE 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 199 YLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKfplqkNLEETSALELD---NIVFMGTNIVSGSAQAV 275
Cdd:cd07539  113 SLVPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDK-----QVAPTPGAPLAdraCMLYEGTTVVSGQGRAV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 276 VLSTGIQTYFGaLAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLP 355
Cdd:cd07539  188 VVATGPHTEAG-RAQSLVAPVETATGVQAQLRELTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLP 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 356 MIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVqggksdfvlmqaflnsyyqtglk 435
Cdd:cd07539  267 LVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRLRVVQVRPP----------------------- 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 436 nlldvavleavddqikiqklrykkLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCE 515
Cdd:cd07539  324 ------------------------LAELPFESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTGGQVVPLTEADR 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 516 VAIEALTQRYNRDGLRVVAVAYREFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFV 595
Cdd:cd07539  380 QAIEEVNELLAGQGLRVLAVAYRTLDAGTTHAVEAVVDDLELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPIT 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 596 TQKVCREISLNYD-QVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADI 674
Cdd:cd07539  460 ARAIAKELGLPRDaEVVTGAELDALDEEALTGLVADIDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADV 539
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 675 GISVDT-AVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQ 753
Cdd:cd07539  540 GIGVGArGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLV 619

                 ....*.
gi 446597779 754 NLLYDV 759
Cdd:cd07539  620 NLLTDM 625
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
68-779 2.79e-95

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 313.99  E-value: 2.79e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKS 147
Cdd:cd07538    1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQEWRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 148 NQAADALKVMVSNTATVLRHQVsaedlelmherygidtknqtthQFEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLF 227
Cdd:cd07538   81 ERALEALKNLSSPRATVIRDGR----------------------ERRIPSRELVPGDLLILGEGERIPADGRLLENDDLG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 228 VSQAAMTGESMPVEKFPLQKNlEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVN 307
Cdd:cd07538  139 VDESTLTGESVPVWKRIDGKA-MSAPGGWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTG 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 308 KVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGA 387
Cdd:cd07538  218 RLVKLCALAALVFCALIVAVYGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGS 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 388 MDVLCTDKTGTLTQdkiflsqhidvqggksdfvlmqaflnsyyqtglknlldvavleavdDQIKIQKLRYkKLDEVPFDF 467
Cdd:cd07538  298 ITVLCVDKTGTLTK----------------------------------------------NQMEVVELTS-LVREYPLRP 330
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 468 DRRRMSVVVQTPqQKARMITKGAVEEMLKVCRYVEVNgkvepltkqcEVAIEALTQRYNRDGLRVVAVAYREFKNhQENY 547
Cdd:cd07538  331 ELRMMGQVWKRP-EGAFAAAKGSPEAIIRLCRLNPDE----------KAAIEDAVSEMAGEGLRVLAVAACRIDE-SFLP 398
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 548 SVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL-NYDQVLLGGVIETLTDQQLKR 626
Cdd:cd07538  399 DDLEDAVFIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGLdNTDNVITGQELDAMSDEELAE 478
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 627 AVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDT-AVDIAKESADLILLEKSLMVLEKGV 705
Cdd:cd07538  479 KVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKrGTDVAREASDIVLLDDNFSSIVSTI 558
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 706 IEGRRTFANMLKyikmtassNFGNVFSVLIASAFIPFLP--------MLPIHLLIQNLLYD-VSQIVIPFDNVDEELIAK 776
Cdd:cd07538  559 RLGRRIYDNLKK--------AITYVFAIHVPIAGLALLPpllglpplLFPVHVVLLELIIDpTCSIVFEAEPAERDIMRR 630

                 ...
gi 446597779 777 PQR 779
Cdd:cd07538  631 PPR 633
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
67-779 6.26e-93

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 313.69  E-value: 6.26e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   67 TGLTEEQAHTQQMTV-GLNE--VTHEKPLtWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQ 143
Cdd:TIGR01522  22 NGLNSSQEASHRRAFhGWNEfdVEEDESL-WKKFLSQFVKNPLILLLIASAVISVFMGNIDDAVSITLAILIVVTVGFVQ 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  144 EAKSNQAADALKVMVSNTATVLRhqvsaedlelmherygidtKNQTTHqfeIPIQYLVPGDVILLSAGDMIPADCRILSA 223
Cdd:TIGR01522 101 EYRSEKSLEALNKLVPPECHLIR-------------------EGKLEH---VLASTLVPGDLVCLSVGDRVPADLRIVEA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  224 KDLFVSQAAMTGESMPVEKF--PLQKNLEETSAlELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTA 301
Cdd:TIGR01522 159 VDLSIDESNLTGETTPVSKVtaPIPAATNGDLA-ERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTP 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  302 FQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDA 381
Cdd:TIGR01522 238 LQKSMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  382 IQNFGAMDVLCTDKTGTLTQDKIFLSqHIDVQGGKSDFV------------LMQAFLNSYYQTGLKNLL----------- 438
Cdd:TIGR01522 318 VETLGSVNVICSDKTGTLTKNHMTVT-KIWTSDGLHTMLnavslnqfgeviVDGDVLHGFYTVAVSRILeagnlcnnakf 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  439 ------------DVAVLEaVDDQIKIQKLR--YKKLDEVPFDFDRRRMSVVVQTPQQKARMI-TKGAVEEMLKVCR-YVE 502
Cdd:TIGR01522 397 rneadtllgnptDVALIE-LLMKFGLDDLRetYIRVAEVPFSSERKWMAVKCVHRQDRSEMCfMKGAYEQVLKYCTyYQK 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  503 VNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNhqenysvvdesDLILIGYITFLDPPKESAKEAVQSLHAHG 582
Cdd:TIGR01522 476 KDGKTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKG-----------QLTFLGLVGINDPPRPGVKEAVTTLITGG 544
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  583 VTVKVLTGDNEFVTQKVCREISLNY--DQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLG 660
Cdd:TIGR01522 545 VRIIMITGDSQETAVSIARRLGMPSktSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTG 624
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  661 DGINDAAAIRAADIGISV-DTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAF 739
Cdd:TIGR01522 625 DGVNDAPALKLADIGVAMgQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLM 704
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....
gi 446597779  740 IPFLPMLPIHLLIQNLLYD----VSQIVIPfdnVDEELIAKPQR 779
Cdd:TIGR01522 705 GFPNPLNAMQILWINILMDgppaQSLGVEP---VDKDVMRKPPR 745
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
82-779 5.65e-90

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 303.55  E-value: 5.65e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  82 GLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNT 161
Cdd:cd02085    6 GPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNKLVPPE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 162 ATVLRhqvsaedlelmherygiDTKNQTthqfeIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVE 241
Cdd:cd02085   86 CHCLR-----------------DGKLEH-----FLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCS 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 242 KF--PLQKNlEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLV 319
Cdd:cd02085  144 KTteVIPKA-SNGDLTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFI 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 320 MAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTL 399
Cdd:cd02085  223 IIGVIMLIGWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTL 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 400 TqdkiflSQHIDVQGGKSDFVLMQAFLNSYYQTGLKNllDVAVLE-AVDDQIKIQKLRYKKLDEVPFDFDRRRMSVVVQT 478
Cdd:cd02085  303 T------KNEMTVTKIVTGCVCNNAVIRNNTLMGQPT--EGALIAlAMKMGLSDIRETYIRKQEIPFSSEQKWMAVKCIP 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 479 PQQKAR---MITKGAVEEMLKVCRYVEV-NGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAyrefknhqenySVVDESD 554
Cdd:cd02085  375 KYNSDNeeiYFMKGALEQVLDYCTTYNSsDGSALPLTQQQRSEINEEEKEMGSKGLRVLALA-----------SGPELGD 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 555 LILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL--NYDQVLLGGVIETLTDQQLKRAVEQYH 632
Cdd:cd02085  444 LTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLysPSLQALSGEEVDQMSDSQLASVVRKVT 523
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 633 IFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVD-TAVDIAKESADLILLEKSLMVLEKGVIEGRRT 711
Cdd:cd02085  524 VFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGrTGTDVCKEAADMILVDDDFSTILAAIEEGKGI 603
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446597779 712 FANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYD----VSQIVIPfdnVDEELIAKPQR 779
Cdd:cd02085  604 FYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDgppaQSLGVEP---VDKDVIRQPPR 672
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
55-758 4.21e-86

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 296.51  E-value: 4.21e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  55 TNDLLKQFDTHLT-GLTEEQAHTQQMTVGLNEVTHEKPLTWWQhlwycyrnpfnillslLALIAFftDD-----LTGSTI 128
Cdd:cd02083    5 VEEVLAYFGVDPTrGLSDEQVKRRREKYGPNELPAEEGKSLWE----------------LVLEQF--DDllvriLLLAAI 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 129 ISV------------------MVILSTLLR-----YWQEAKSNQAADALKVMVSNTATVLR-----HQVSAEDLelmher 180
Cdd:cd02083   67 ISFvlalfeegeegvtafvepFVILLILIAnavvgVWQERNAEKAIEALKEYEPEMAKVLRngkgvQRIRAREL------ 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 181 ygidtknqtthqfeipiqylVPGDVILLSAGDMIPADCRILSAKD--LFVSQAAMTGESMPVEKFplQKNLEETSALELD 258
Cdd:cd02083  141 --------------------VPGDIVEVAVGDKVPADIRIIEIKSttLRVDQSILTGESVSVIKH--TDVVPDPRAVNQD 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 259 --NIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFIN-------- 328
Cdd:cd02083  199 kkNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEEEKTPLQQKLDEFGEQLSKVISVICVAVWAINighfndpa 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 329 ---GFTKGdwaeA---FLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQD 402
Cdd:cd02083  279 hggSWIKG----AiyyFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTN 354
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 403 -----KIFLSQHIDVQGGKSDF------------VLMQ-------------------AFLN---SYY------------- 430
Cdd:cd02083  355 qmsvsRMFILDKVEDDSSLNEFevtgstyapegeVFKNgkkvkagqydglvelaticALCNdssLDYneskgvyekvgea 434
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 431 -QTGLKNLL--------DVAVLEAVDDQI----KIQKlRYKKLDEVPFDFDRRRMSVVVQ--TPQQKARMITKGAVEEML 495
Cdd:cd02083  435 tETALTVLVekmnvfntDKSGLSKRERANacndVIEQ-LWKKEFTLEFSRDRKSMSVYCSptKASGGNKLFVKGAPEGVL 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 496 KVCRYVEVN-GKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENYSVVD-------ESDLILIGYITFLDPP 567
Cdd:cd02083  514 ERCTHVRVGgGKVVPLTAAIKILILKKVWGYGTDTLRCLALATKDTPPKPEDMDLEDstkfykyETDLTFVGVVGMLDPP 593
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 568 KESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGV------IETLTDQQLKRAVEQYHIFAKLSPVH 641
Cdd:cd02083  594 RPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDTTGKsytgreFDDLSPEEQREACRRARLFSRVEPSH 673
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 642 KERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKM 721
Cdd:cd02083  674 KSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRY 753
                        810       820       830
                 ....*....|....*....|....*....|....*....
gi 446597779 722 TASSNFGNVFSVLIASAFipFLP--MLPIHLLIQNLLYD 758
Cdd:cd02083  754 LISSNIGEVVSIFLTAAL--GLPeaLIPVQLLWVNLVTD 790
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
128-779 1.64e-85

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 294.00  E-value: 1.64e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  128 IISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRH----QVSAEDLelmherygidtknqtthqfeipiqylVPG 203
Cdd:TIGR01116  41 VILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRDgrwsVIKAKDL--------------------------VPG 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  204 DVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKF--PLQKNLEETSALEldNIVFMGTNIVSGSAQAVVLSTGI 281
Cdd:TIGR01116  95 DIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHteSVPDERAVNQDKK--NMLFSGTLVVAGKARGVVVRTGM 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  282 QTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFIN------GFTKGDWAEAFLFALSVAVGLT----P 351
Cdd:TIGR01116 173 STEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINighfndPALGGGWIQGAIYYFKIAVALAvaaiP 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  352 EMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQD-----KIFLSQHID--------------- 411
Cdd:TIGR01116 253 EGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNqmsvcKVVALDPSSsslnefcvtgttyap 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  412 ----------VQGGKSDFVLMQA-----------FLNS----YYQTGL------------------KNLLDVAVLEAvDD 448
Cdd:TIGR01116 333 eggvikddgpVAGGQDAGLEELAtiaalcndsslDFNErkgvYEKVGEateaalkvlvekmglpatKNGVSSKRRPA-LG 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  449 QIKIQKLRYKKLDEVPFDFDRRRMSVVVqTPQQKARMITKGAVEEMLKVCRYVEV-NGKVEPLTKQCEVAIEALTQRY-N 526
Cdd:TIGR01116 412 CNSVWNDKFKKLATLEFSRDRKSMSVLC-KPSTGNKLFVKGAPEGVLERCTHILNgDGRAVPLTDKMKNTILSVIKEMgT 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  527 RDGLRVVAVAYREFKNHQENYSVVD-------ESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKV 599
Cdd:TIGR01116 491 TKALRCLALAFKDIPDPREEDLLSDpanfeaiESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAI 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  600 CREISL------NYDQVLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAAD 673
Cdd:TIGR01116 571 CRRIGIfspdedVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELLQEQGEIVAMTGDGVNDAPALKKAD 650
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  674 IGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQ 753
Cdd:TIGR01116 651 IGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWV 730
                         730       740
                  ....*....|....*....|....*..
gi 446597779  754 NLLYD-VSQIVIPFDNVDEELIAKPQR 779
Cdd:TIGR01116 731 NLVTDgLPATALGFNPPDKDIMWKPPR 757
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
68-756 3.08e-81

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 282.04  E-value: 3.08e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGSTIISVMVILSTLLRYWQEAKS 147
Cdd:cd02086    1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFAVKDWIEGGVIAAVIALNVIVGFIQEYKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 148 NQAADALKVMVSNTATVLRHQVSAEdlelmherygidtknqtthqfeIPIQYLVPGDVILLSAGDMIPADCRILSAKDLF 227
Cdd:cd02086   81 EKTMDSLRNLSSPNAHVIRSGKTET----------------------ISSKDVVPGDIVLLKVGDTVPADLRLIETKNFE 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 228 VSQAAMTGESMPVEKF--PLQKNLEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALA---------------- 289
Cdd:cd02086  139 TDEALLTGESLPVIKDaeLVFGKEEDVSVGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAkalrgkgglisrdrvk 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 290 ----HRVTATDRSTTAF---------QMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDwaEAFLFALSVAVGLTPEMLPM 356
Cdd:cd02086  219 swlyGTLIVTWDAVGRFlgtnvgtplQRKLSKLAYLLFFIAVILAIIVFAVNKFDVDN--EVIIYAIALAISMIPESLVA 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 357 IVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIflsqhidvqggksdfVLMQAFLnsyyQTGLKN 436
Cdd:cd02086  297 VLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKM---------------VVRQVWI----PAALCN 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 437 LLDVAVLEAVDD--------QIKIQ----KLRYKKLD-------------EVPFDFDRRRMSVVVQTPQQKARMI-TKGA 490
Cdd:cd02086  358 IATVFKDEETDCwkahgdptEIALQvfatKFDMGKNAltkggsaqfqhvaEFPFDSTVKRMSVVYYNNQAGDYYAyMKGA 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 491 VEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENYSVVD---------ESDLILIGYI 561
Cdd:cd02086  438 VERVLECCSSMYGKDGIIPLDDEFRKTIIKNVESLASQGLRVLAFASRSFTKAQFNDDQLKnitlsradaESDLTFLGLV 517
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 562 TFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREI------SLNYDQVLLGGVIET------LTDQQLKRAVE 629
Cdd:cd02086  518 GIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVgilppnSYHYSQEIMDSMVMTasqfdgLSDEEVDALPV 597
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 630 QYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTA-VDIAKESADLILLEKSLMVLEKGVIEG 708
Cdd:cd02086  598 LPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNgSDVAKDASDIVLTDDNFASIVNAIEEG 677
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446597779 709 RRTFANMLKYIKMTASSNFGNVFSVLIASAF-----IPFLPMLPIHLLIQNLL 756
Cdd:cd02086  678 RRMFDNIQKFVLHLLAENVAQVILLLIGLAFkdedgLSVFPLSPVEILWINMV 730
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
194-758 4.85e-73

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 255.21  E-value: 4.85e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKFPLQKNleetsaleLDNIVFMGTNIVSGSAQ 273
Cdd:cd02081  112 QISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDPIKKTPDNQI--------PDPFLLSGTKVLEGSGK 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 274 AVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVL-------FINGFTKGDWA---------- 336
Cdd:cd02081  184 MLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIVAALTFivliirfIIDGFVNDGKSfsaedlqefv 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 337 EAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFlsqhidvqggk 416
Cdd:cd02081  264 NFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMT----------- 332
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 417 sdfvLMQAFLNSYYQTGlknLLDVAVLEAVDDQIKIQKLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLK 496
Cdd:cd02081  333 ----VVQGYIGNKTECA---LLGFVLELGGDYRYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLK 405
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 497 VC-RYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREF-------KNHQENYSVVDESDLILIGYITFLDPPK 568
Cdd:cd02081  406 KCsYILNSDGEVVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFspdeeptAERDWDDEEDIESDLTFIGIVGIKDPLR 485
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 569 ESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL----NYDQVLLGGVIETLTDQQLKRAV--------EQYHIFAK 636
Cdd:cd02081  486 PEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGIltegEDGLVLEGKEFRELIDEEVGEVCqekfdkiwPKLRVLAR 565
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 637 LSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISV-DTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANM 715
Cdd:cd02081  566 SSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMgIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSI 645
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 446597779 716 LKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYD 758
Cdd:cd02081  646 RKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMD 688
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
390-758 6.96e-67

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 226.56  E-value: 6.96e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 390 VLCTDKTGTLTQDKiflsqhidvqggksdfvlmqaflnsyyqtglknlldvavLEAVDDQIKiqklrykkldEVPFDFDR 469
Cdd:cd01431    1 VICSDKTGTLTKNG---------------------------------------MTVTKLFIE----------EIPFNSTR 31
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 470 RRMSVVVQTPQqKARMITKGAVEEMLKVCRYVEVNGKveplTKQCEVAIEAltqrYNRDGLRVVAVAYREFKNHQENYSV 549
Cdd:cd01431   32 KRMSVVVRLPG-RYRAIVKGAPETILSRCSHALTEED----RNKIEKAQEE----SAREGLRVLALAYREFDPETSKEAV 102
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 550 vdESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL--NYDQVLLGGVIETLTDQQLKRA 627
Cdd:cd01431  103 --ELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGIdtKASGVILGEEADEMSEEELLDL 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 628 VEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISV-DTAVDIAKESADLILLEKSLMVLEKGVI 706
Cdd:cd01431  181 IAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMgSTGTDVAKEAADIVLLDDNFATIVEAVE 260
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446597779 707 EGRRTFANMLKYIKMTASSNFGNVFSVLIASAFIPFLPMLPIHLLIQNLLYD 758
Cdd:cd01431  261 EGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTD 312
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
49-756 1.59e-63

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 232.98  E-value: 1.59e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779    49 NASRAQTNDLLKQF-DTHLT-GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFNILLSLLALIAFFTDDLTGS 126
Cdd:TIGR01523    5 NAYFSDIADEAAEFiGTSIPeGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMHDWIEG 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   127 TIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRHQVSAedlelmheryGIDTKNqtthqfeipiqyLVPGDVI 206
Cdd:TIGR01523   85 GVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSD----------AIDSHD------------LVPGDIC 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   207 LLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEK---FPLQKNlEETSALELDNIVFMGTNIVSGSAQAVVLSTGIQT 283
Cdd:TIGR01523  143 LLKTGDTIPADLRLIETKNFDTDEALLTGESLPVIKdahATFGKE-EDTPIGDRINLAFSSSAVTKGRAKGICIATALNS 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   284 YFGALA----------HRVTATDRST-------------------------TAFQMGVNKVSWLLIRFMLVMAPVVLFIN 328
Cdd:TIGR01523  222 EIGAIAaglqgdgglfQRPEKDDPNKrrklnkwilkvtkkvtgaflglnvgTPLHRKLSKLAVILFCIAIIFAIIVMAAH 301
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   329 GFTKGDwaEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQ 408
Cdd:TIGR01523  302 KFDVDK--EVAIYAICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQ 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   409 -------HIDV----------QGGKSDFVLMQAFLNSYYQTG----------------------------------LKNL 437
Cdd:TIGR01523  380 iwiprfgTISIdnsddafnpnEGNVSGIPRFSPYEYSHNEAAdqdilkefkdelkeidlpedidmdlfiklletaaLANI 459
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   438 LDVAVLEAVDD--------QIKIQ--------------------------------------KLRYKKLDEVPFDFDRRR 471
Cdd:TIGR01523  460 ATVFKDDATDCwkahgdptEIAIHvfakkfdlphnaltgeedllksnendqsslsqhnekpgSAQFEFIAEFPFDSEIKR 539
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   472 MSVVVQTPQ-QKARMITKGAVEEMLKVCR--YVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQENYS 548
Cdd:TIGR01523  540 MASIYEDNHgETYNIYAKGAFERIIECCSssNGKDGVKISPLEDCDRELIIANMESLAAEGLRVLAFASKSFDKADNNDD 619
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   549 V---------VDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL------NYDQ---- 609
Cdd:TIGR01523  620 QlknetlnraTAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIippnfiHDRDeimd 699
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   610 --VLLGGVIETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVD-TAVDIAK 686
Cdd:TIGR01523  700 smVMTGSQFDALSDEEVDDLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGiNGSDVAK 779
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597779   687 ESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIASAF-----IPFLPMLPIHLLIQNLL 756
Cdd:TIGR01523  780 DASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFrdengKSVFPLSPVEILWCIMI 854
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
192-758 8.94e-61

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 223.89  E-value: 8.94e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  192 QFEIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKFPLQknleetsalelDNIVFMGTNIVSGS 271
Cdd:TIGR01517 179 EQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQ-----------DPFLLSGTVVNEGS 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  272 AQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAP---VVLFINGFTKGDWAEA---------- 338
Cdd:TIGR01517 248 GRMLVTAVGVNSFGGKLMMELRQAGEEETPLQEKLSELAGLIGKFGMGSAVllfLVLSLRYVFRIIRGDGrfedteedaq 327
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  339 -----FLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQ------------ 401
Cdd:TIGR01517 328 tfldhFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQnvmsvvqgyige 407
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  402 ------DKIFL------SQHIDVQG---GKSDFVL-----MQAFLNSYYQTGLKNLLDVAVLEAVDDQIKIQKLRYKKLd 461
Cdd:TIGR01517 408 qrfnvrDEIVLrnlpaaVRNILVEGislNSSSEEVvdrggKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKI- 486
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  462 eVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYV-EVNGKVEPLT----KQCEVAIEALTQrynrDGLRVVAVA 536
Cdd:TIGR01517 487 -YPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRlDSNGEATPISeddkDRCADVIEPLAS----DALRTICLA 561
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  537 YREFKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREIS-LNYDQVLLGGV 615
Cdd:TIGR01517 562 YRDFAPEEFPRKDYPNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGiLTFGGLAMEGK 641
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  616 -IETLTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTA-VDIAKESADLIL 693
Cdd:TIGR01517 642 eFRSLVYEEMDPILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISgTEVAKEASDIIL 721
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  694 LEKSLMVLEKGVIEGRRTFANMLKYIKMTASSnfgNVFSVLIA--SAFIPFL---PMLPIHLLIQNLLYD 758
Cdd:TIGR01517 722 LDDNFASIVRAVKWGRNVYDNIRKFLQFQLTV---NVVAVILTfvGSCISSShtsPLTAVQLLWVNLIMD 788
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
121-779 1.14e-60

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 223.90  E-value: 1.14e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  121 DDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRHqvsaedlelmherygidtknqtTHQFEIPIQYL 200
Cdd:TIGR01106 102 DNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRD----------------------GEKMSINAEQV 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  201 VPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKFPlqkNLEETSALELDNIVFMGTNIVSGSAQAVVLSTG 280
Cdd:TIGR01106 160 VVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSP---EFTHENPLETRNIAFFSTNCVEGTARGIVVNTG 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  281 IQTYFGALAHRVTATDRSTTAFQMGVNKVSWLlIRFMLVMAPVVLFINGFTKG-DWAEAFLFALSVAVGLTPEMLPMIVT 359
Cdd:TIGR01106 237 DRTVMGRIASLASGLENGKTPIAIEIEHFIHI-ITGVAVFLGVSFFILSLILGyTWLEAVIFLIGIIVANVPEGLLATVT 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  360 STLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQ-----HI---DVQGGKSDFVLMQAFLNSYYQ 431
Cdd:TIGR01106 316 VCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHmwfdnQIheaDTTEDQSGVSFDKSSATWLAL 395
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  432 TGLKNLLDVAVLEAVDDQIKIQKL---------------------------RYKKLDEVPFD-FDRRRMSVVVQ--TPQQ 481
Cdd:TIGR01106 396 SRIAGLCNRAVFKAGQENVPILKRavagdasesallkcielclgsvmemreRNPKVVEIPFNsTNKYQLSIHENedPRDP 475
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  482 KARMITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVA--YREFKNHQENYSV-VDE-----S 553
Cdd:TIGR01106 476 RHLLVMKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFChlYLPDEQFPEGFQFdTDDvnfptD 555
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  554 DLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGD------------------NEFVtQKVCREISLNYDQ------ 609
Cdd:TIGR01106 556 NLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDhpitakaiakgvgiisegNETV-EDIAARLNIPVSQvnprda 634
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  610 ---VLLGGVIETLTDQQLKRAVeQYH---IFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTA-V 682
Cdd:TIGR01106 635 kacVVHGSDLKDMTSEQLDEIL-KYHteiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAgS 713
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  683 DIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLI-ASAFIPfLPMLPIHLLIQNLLYD-VS 760
Cdd:TIGR01106 714 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIfIIANIP-LPLGTITILCIDLGTDmVP 792
                         730
                  ....*....|....*....
gi 446597779  761 QIVIPFDNVDEELIAKPQR 779
Cdd:TIGR01106 793 AISLAYEKAESDIMKRQPR 811
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
68-750 1.73e-60

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 218.30  E-value: 1.73e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  68 GLTEEQAhTQQMTVGL-NEVTHEKPLTWWQHLwycYRNP---FNILLSLLALIAFFTDDLTGSTIISVmVILSTLLRYWQ 143
Cdd:cd02609    1 GLTTKEV-EERQAEGKvNDQVEPVSRSVWQIV---RENVftlFNLINFVIAVLLILVGSYSNLAFLGV-IIVNTVIGIVQ 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 144 EAKSNQAADALKVMVSNTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDVILLSAGDMIPADCRILSA 223
Cdd:cd02609   76 EIRAKRQLDKLSILNAPKVTVIR-----------------DGQEV-----KIPPEELVLDDILILKPGEQIPADGEVVEG 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 224 KDLFVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQ 303
Cdd:cd02609  134 GGLEVDESLLTGESDLIPKKA-------------GDKLLSGSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELL 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 304 MGVNKV----SWLLIRFMLVMAPVVLFINGftkGDWAEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRL 379
Cdd:cd02609  201 NSINKIlkftSFIIIPLGLLLFVEALFRRG---GGWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQEL 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 380 DAIQNFGAMDVLCTDKTGTLTQDKIFLSQ--HIDVQGGKSDFVLMQAFLNSYYQtglKNLLDVAVLEA--VDDQIKIQkl 455
Cdd:cd02609  278 YSIETLARVDVLCLDKTGTITEGKMKVERvePLDEANEAEAAAALAAFVAASED---NNATMQAIRAAffGNNRFEVT-- 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 456 rykklDEVPFDFDRRRMSVVVQTPQQkarmITKGAvEEMLKVCRYVEVNGKVEPLTKQcevaiealtqrynrdGLRVVAV 535
Cdd:cd02609  353 -----SIIPFSSARKWSAVEFRDGGT----WVLGA-PEVLLGDLPSEVLSRVNELAAQ---------------GYRVLLL 407
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 536 AY--REFKNHQENysvvdeSDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISL-NYDQVLL 612
Cdd:cd02609  408 ARsaGALTHEQLP------VGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGLeGAESYID 481
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 613 GGVIEtlTDQQLKRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLI 692
Cdd:cd02609  482 ASTLT--TDEELAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASGSDATRQVAQVV 559
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446597779 693 LLEKSLMVLEKGVIEGRRTFANM-----LKYIKmtassnfgNVFSVLIASAFI----PFlPMLPIHL 750
Cdd:cd02609  560 LLDSDFSALPDVVFEGRRVVNNIervasLFLVK--------TIYSVLLALICVitalPF-PFLPIQI 617
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
121-759 5.56e-58

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 214.91  E-value: 5.56e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 121 DDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRhqvsaeDLElmherygidtknqtthQFEIPIQYL 200
Cdd:cd02608   67 DNLYLGIVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIR------DGE----------------KMQINAEEL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 201 VPGDVILLSAGDMIPADCRILSAKDLFVSQAAMTGESMPVEKFPlqkNLEETSALELDNIVFMGTNIVSGSAQAVVLSTG 280
Cdd:cd02608  125 VVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTRSP---EFTHENPLETKNIAFFSTNCVEGTARGIVINTG 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 281 IQTYFGALAHRVTATDRSTTAFQMGVNkvswLLIRFMLVMA---PVVLFINGFTKG-DWAEAFLFALSVAVGLTPEMLPM 356
Cdd:cd02608  202 DRTVMGRIATLASGLEVGKTPIAREIE----HFIHIITGVAvflGVSFFILSLILGyTWLEAVIFLIGIIVANVPEGLLA 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 357 IVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSqHI--DVQGGKSDFVLMQAFlNSYYQT-- 432
Cdd:cd02608  278 TVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVA-HMwfDNQIHEADTTEDQSG-ASFDKSsa 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 433 GLKNLLDVAVL------EAVDDQIKIQKL---------------------------RYKKLDEVPFD-FDRRRMSVVVQT 478
Cdd:cd02608  356 TWLALSRIAGLcnraefKAGQENVPILKRdvngdasesallkcielscgsvmemreRNPKVAEIPFNsTNKYQLSIHENE 435
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 479 PQQKAR--MITKGAVEEMLKVCRYVEVNGKVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREFKNHQ--ENYSV-VDE- 552
Cdd:cd02608  436 DPGDPRylLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHLYLPDDKfpEGFKFdTDEv 515
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 553 ----SDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREIslnydqvllgGVIetltdqqlkrav 628
Cdd:cd02608  516 nfptENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGV----------GII------------ 573
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 629 eqyhIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTA-VDIAKESADLILLEKSLMVLEKGVIE 707
Cdd:cd02608  574 ----VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASIVTGVEE 649
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446597779 708 GRRTFANMLKYIKMTASSNFGNVFSVLIasaFIPF---LPMLPIHLLIQNLLYDV 759
Cdd:cd02608  650 GRLIFDNLKKSIAYTLTSNIPEITPFLI---FIIAnipLPLGTITILCIDLGTDM 701
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
130-742 4.07e-50

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 189.20  E-value: 4.07e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 130 SVMVILSTLL-RYWQE---AKSNQAADALKVMVSNTATVLRhqvsaedlelmherygidtkNQTTHqfEIPIQYLVPGDV 205
Cdd:COG2217  179 AAMIIFLLLLgRYLEArakGRARAAIRALLSLQPKTARVLR--------------------DGEEV--EVPVEELRVGDR 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 206 ILLSAGDMIPADCRIL---SAkdlfVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQAVVLSTGIQ 282
Cdd:COG2217  237 VLVRPGERIPVDGVVLegeSS----VDESMLTGESLPVEKTP-------------GDEVFAGTINLDGSLRVRVTKVGSD 299
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 283 TYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSV-------AVGL-TPeml 354
Cdd:COG2217  300 TTLARIIRLVEEAQSSKAPIQRLADRIARYFVPAVLAIAALTFLVWLLFGGDFSTALYRAVAVlviacpcALGLaTP--- 376
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 355 pMIVTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAflnsyyqtgl 434
Cdd:COG2217  377 -TAIMVGTGRAA----RRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDGLDEDELLALA---------- 441
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 435 knlldvAVLE---------AVDDQIKIQKLRYKKLDEVpfdfdrrrmsvvvqtpqqkaRMIT-KGaVEemlkvcryVEVN 504
Cdd:COG2217  442 ------AALEqgsehplarAIVAAAKERGLELPEVEDF--------------------EAIPgKG-VE--------ATVD 486
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 505 GK---------VEPLTKQCEVAIEALTQRYNRDGLRVVAVAyrefknhqenysvVDESdliLIGYITFLDPPKESAKEAV 575
Cdd:COG2217  487 GKrvlvgsprlLEEEGIDLPEALEERAEELEAEGKTVVYVA-------------VDGR---LLGLIALADTLRPEAAEAI 550
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 576 QSLHAHGVTVKVLTGDNEFVTQKVCREislnydqvlLGgvIEtltdqqlkraveqyHIFAKLSPVHKERIVEQLKANGHV 655
Cdd:COG2217  551 AALKALGIRVVMLTGDNERTAEAVARE---------LG--ID--------------EVRAEVLPEDKAAAVRELQAQGKK 605
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 656 VGFLGDGINdaaairaadiGISVDTAVDIAKESADLILLEKSLMVLEKgVIE-GRRTFANmlkyIKmtasSNFGnvFSVL 734
Cdd:COG2217  606 VAMVGDGINdapalaaadvGIAMGSGTDVAIEAADIVLMRDDLRGVPD-AIRlSRATMRI----IR----QNLF--WAFG 674

                 ....*...
gi 446597779 735 IASAFIPF 742
Cdd:COG2217  675 YNVIGIPL 682
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
118-743 1.67e-48

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 181.68  E-value: 1.67e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  118 FFTDDLTGSTIIsVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRHQVSAEdlelmherygidtknqtthqfEIPI 197
Cdd:TIGR01525  14 AMGLVLEGALLL-FLFLLGETLEERAKSRASDALSALLALAPSTARVLQGDGSEE---------------------EVPV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  198 QYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQAVVL 277
Cdd:TIGR01525  72 EELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVEKKE-------------GDEVFAGTINGDGSLTIRVT 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  278 STGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEML--- 354
Cdd:TIGR01525 138 KLGEDSTLAQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALgla 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  355 -PMIVTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLmqaflnsYYQTG 433
Cdd:TIGR01525 218 tPVAILVAIGAAA----RRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPLDDASEEELL-------ALAAA 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  434 LKNLLDVAVLEAVDDQIKIQKLRykkldevpfdfdrrrmsvvvqTPQQKARMIT----KGAVEEMLKVCRYVEVNGKVEP 509
Cdd:TIGR01525 287 LEQSSSHPLARAIVRYAKERGLE---------------------LPPEDVEEVPgkgvEATVDGGREVRIGNPRFLGNRE 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  510 LTKQCEVAIEALTQRYNRDGLRVVAVAyrefknhqenysVVDEsdliLIGYITFLDPPKESAKEAVQSL-HAHGVTVKVL 588
Cdd:TIGR01525 346 LAIEPISASPDLLNEGESQGKTVVFVA------------VDGE----LLGVIALRDQLRPEAKEAIAALkRAGGIKLVML 409
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  589 TGDNEFVTQKVCREISLNYDqvllggvietltdqqlkraveqyhIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAA 668
Cdd:TIGR01525 410 TGDNRSAAEAVAAELGIDDE------------------------VHAELLPEDKLAIVKKLQEEGGPVAMVGDGINDAPA 465
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597779  669 IRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFgnVFSVLIASAFIPFL 743
Cdd:TIGR01525 466 LAAADVGIAMGSGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNL--VAIPLAAGGLLPLW 538
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
126-746 4.05e-46

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 175.48  E-value: 4.05e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 126 STIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRhQVSAEdlelmherygidtknqtthqfEIPIQYLVPGDV 205
Cdd:cd02079   91 AAMLLFLFLLGRYLEERARSRARSALKALLSLAPETATVLE-DGSTE---------------------EVPVDDLKVGDV 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 206 ILLSAGDMIPADCRILSaKDLFVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQAVVLSTGIQTYF 285
Cdd:cd02079  149 VLVKPGERIPVDGVVVS-GESSVDESSLTGESLPVEKGA-------------GDTVFAGTINLNGPLTIEVTKTGEDTTL 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 286 GALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSV-------AVGLTPemlPMIV 358
Cdd:cd02079  215 AKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLALYRALAVlvvacpcALGLAT---PTAI 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 359 TSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLMQAflnSYYQTGLKNLL 438
Cdd:cd02079  292 VAGIGRAA----RKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEPLEGFSEDELLALA---AALEQHSEHPL 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 439 DVAVLEAVDDQIkIQKLRYKKLDEVPfdfdrrrmsvvvqtpqqkarmiTKGAveemlkvcrYVEVNGKVEPLTKQCEVAI 518
Cdd:cd02079  365 ARAIVEAAEEKG-LPPLEVEDVEEIP----------------------GKGI---------SGEVDGREVLIGSLSFAEE 412
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 519 EALTQRY----NRDGLRVVAVAyrefknhqenysvvdeSDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEF 594
Cdd:cd02079  413 EGLVEAAdalsDAGKTSAVYVG----------------RDGKLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEA 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 595 VTQKVCREislnydqvlLGgvietltdqqlkraVEQYHifAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADI 674
Cdd:cd02079  477 AAQAVAKE---------LG--------------IDEVH--AGLLPEDKLAIVKALQAEGGPVAMVGDGINDAPALAQADV 531
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446597779 675 GISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFgnvfsVLIASAFIPFLPML 746
Cdd:cd02079  532 GIAMGSGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNA-----IALPLAALGLLTPW 598
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
130-747 4.45e-41

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 159.75  E-value: 4.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  130 SVMVILSTLLRYWQEAKS-NQAADALKVMVSN---TATVLrhqvsaedlelmherygidTKNQTTHqfEIPIQYLVPGDV 205
Cdd:TIGR01511  57 SAMLITFILLGRWLEMLAkGRASDALSKLAKLqpsTATLL-------------------TKDGSIE--EVPVALLQPGDI 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  206 ILLSAGDMIPADCRILSAKDlFVSQAAMTGESMPVEKfplqknleetsalELDNIVFMGTniVSGSaqavvlstgiqtyf 285
Cdd:TIGR01511 116 VKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPK-------------KVGDPVIAGT--VNGT-------------- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  286 GALAHRVTATDRSTT---------AFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSV-------AVGL 349
Cdd:TIGR01511 166 GSLVVRATATGEDTTlaqivrlvrQAQQSKAPIQRLADKVAGYFVPVVIAIALITFVIWLFALEFAVTVliiacpcALGL 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  350 TPEMLPMIVTSTLAKGAVFlskkkviVKRLDAIQNFGAMDVLCTDKTGTLTQDKiflsqhidvqggksdFVLMQA-FLNS 428
Cdd:TIGR01511 246 ATPTVIAVATGLAAKNGVL-------IKDGDALERAANIDTVVFDKTGTLTQGK---------------PTVTDVhVFGD 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  429 YYQTGLKNLldVAVLEAVDDQikiqklrykkldevPFDfdrrrMSVVVQTPQQKARMITKGAVeemlKVCRYVEVNGKVE 508
Cdd:TIGR01511 304 RDRTELLAL--AAALEAGSEH--------------PLA-----KAIVSYAKEKGITLVTVSDF----KAIPGIGVEGTVE 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  509 PLTkqcevaIEALTQRY-NRDGLRVVAvayrefKNHQENYSVVDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKV 587
Cdd:TIGR01511 359 GTK------IQLGNEKLlGENAIKIDG------KAGQGSTVVLVAVNGELAGVFALEDQLRPEAKEVIQALKRRGIEPVM 426
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  588 LTGDNEFVTQKVCREISLNYdqvllggvietltdqqlkraveqyhiFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAA 667
Cdd:TIGR01511 427 LTGDNRKTAKAVAKELGIDV--------------------------RAEVLPDDKAALIKKLQEKGPVVAMVGDGINDAP 480
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  668 AIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMlkyikmtaSSNFG-----NVFSVLIA-SAFIP 741
Cdd:TIGR01511 481 ALAQADVGIAIGAGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRI--------KQNLLwafgyNVIAIPIAaGVLYP 552

                  ....*.
gi 446597779  742 FLPMLP 747
Cdd:TIGR01511 553 IGILLS 558
E1-E2_ATPase pfam00122
E1-E2 ATPase;
194-372 7.84e-41

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 148.10  E-value: 7.84e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQ 273
Cdd:pfam00122  17 EVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEKKK-------------GDMVYSGTVVVSGSAK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  274 AVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVGLTPEM 353
Cdd:pfam00122  83 AVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALLRALAVLVAACPCA 162
                         170
                  ....*....|....*....
gi 446597779  354 LPMIVTSTLAKGAVFLSKK 372
Cdd:pfam00122 163 LPLATPLALAVGARRLAKK 181
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
118-754 1.42e-39

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 154.79  E-value: 1.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  118 FFTDDLTGSTIISVMVILSTLLRYWQEAKSNQAADALKVMVSNTATVLRhqvsAEDLElmherygidtknqtthqfEIPI 197
Cdd:TIGR01512  13 VAIGEYLEGALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQ----GDSLE------------------EVAV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  198 QYLVPGDVILLSAGDMIPADCRILSAKDLFvSQAAMTGESMPVEKFPLQKnleetsaleldniVFMGTNIVSGSAQAVVL 277
Cdd:TIGR01512  71 EELKVGDVVVVKPGERVPVDGEVLSGTSSV-DESALTGESVPVEKAPGDE-------------VFAGAINLDGVLTIEVT 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  278 STGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFING-FTKGDWAEAFLFALSVAVGLTPEMLPM 356
Cdd:TIGR01512 137 KLPADSTIAKIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPlLGAGPFLEWIYRALVLLVVASPCALVI 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  357 IVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQhIDVQGGKSDFVLMQafLNSYYQTGLKN 436
Cdd:TIGR01512 217 SAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD-VHPADGHSESEVLR--LAAAAEQGSTH 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  437 LLDVAVLEAVddQIKIQKLRYKKLDEVPfdfdRRRMSVVVQTpqQKARMITKGAVEEmlkvcryvevngkvepltkqcev 516
Cdd:TIGR01512 294 PLARAIVDYA--RARELAPPVEDVEEVP----GEGVRAVVDG--GEVRIGNPRSLSE----------------------- 342
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  517 AIEALTQRYNRDGLRVVAVAyrefKNHQenysvvdesdliLIGYITFLDPPKESAKEAVQSLHAHGVTVKV-LTGDNEFV 595
Cdd:TIGR01512 343 AVGASIAVPESAGKTIVLVA----RDGT------------LLGYIALSDELRPDAAEAIAELKALGIKRLVmLTGDRRAV 406
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  596 TQKVCREislnydqvlLGgvietltdqqlkraVEQYHifAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIG 675
Cdd:TIGR01512 407 AEAVARE---------LG--------------IDEVH--AELLPEDKLEIVKELREKAGPVAMVGDGINDAPALAAADVG 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  676 ISVDTA-VDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFgnvfsVLIASAFIPFLPmLPIHLLIQN 754
Cdd:TIGR01512 462 IAMGASgSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIIL-----VLILLALFGVLP-LWLAVLGHE 535
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
130-750 6.98e-39

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 154.17  E-value: 6.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 130 SVMVILSTLLRYWQEAKS-NQAADALKVMVS---NTATVLRhqvsaedlelmherygiDTKNQtthqfEIPIQYLVPGDV 205
Cdd:cd02094  105 AAVIITFILLGKYLEARAkGKTSEAIKKLLGlqpKTARVIR-----------------DGKEV-----EVPIEEVQVGDI 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 206 ILLSAGDMIPADCRILSAKDlFVSQAAMTGESMPVEKFPlqknleetsaleldnivfmGTNIVSGSaqaVVLStgiqtyf 285
Cdd:cd02094  163 VRVRPGEKIPVDGVVVEGES-SVDESMLTGESLPVEKKP-------------------GDKVIGGT---INGN------- 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 286 GALAHRVTATDRSTTAFQMG----------------VNKVSwllirfmLVMAPVVLFINGFT---------KGDWAEAFL 340
Cdd:cd02094  213 GSLLVRATRVGADTTLAQIIrlveeaqgskapiqrlADRVS-------GVFVPVVIAIAILTflvwlllgpEPALTFALV 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 341 FALSV-------AVGL-TPeMLPMIVTStlaKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDV 412
Cdd:cd02094  286 AAVAVlviacpcALGLaTP-TAIMVGTG---RAA----ELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPL 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 413 QGGKSDFVLmqaFLnsyyqtglknlldVAVLEAvddqikiqklrykkLDEVPFdfdrrrmsvvvqtpqqkARMITKGAVE 492
Cdd:cd02094  358 PGDDEDELL---RL-------------AASLEQ--------------GSEHPL-----------------AKAIVAAAKE 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 493 EML---KVCRYVEVNGK-VEPLTKQCEVAI--EALTQRYNRDGLRVVAVAyreFKNHQENYSVV-DESDLILIGYITFLD 565
Cdd:cd02094  391 KGLelpEVEDFEAIPGKgVRGTVDGRRVLVgnRRLMEENGIDLSALEAEA---LALEEEGKTVVlVAVDGELAGLIAVAD 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 566 PPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREislnydqvlLGgvIEtltdqqlkraveqyHIFAKLSPVHKERI 645
Cdd:cd02094  468 PLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKE---------LG--ID--------------EVIAEVLPEDKAEK 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 646 VEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANmlkyIKMtass 725
Cdd:cd02094  523 VKKLQAQGKKVAMVGDGINDAPALAQADVGIAIGSGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRN----IKQ---- 594
                        650       660       670
                 ....*....|....*....|....*....|
gi 446597779 726 NFG-----NVFSVLIAsAFIpFLPMLPIHL 750
Cdd:cd02094  595 NLFwafiyNVIGIPLA-AGV-LYPFGGILL 622
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
128-664 1.94e-38

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 153.94  E-value: 1.94e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 128 IISVMVILSTLLrywqEAKSNQaaDALKVMVSNT--ATVLRHQVSaedlelmherygidtknqtthqFEIPIQYLVPGDV 205
Cdd:cd07542   59 IISVISIFLSLY----ETRKQS--KRLREMVHFTcpVRVIRDGEW----------------------QTISSSELVPGDI 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 206 ILLSA-GDMIPADCrILSAKDLFVSQAAMTGESMPVEKFPLQKN-LEETSALELDNIV-----FMGTNIV------SGSA 272
Cdd:cd07542  111 LVIPDnGTLLPCDA-ILLSGSCIVNESMLTGESVPVTKTPLPDEsNDSLWSIYSIEDHskhtlFCGTKVIqtrayeGKPV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 273 QAVVLSTGIQTYFGALAhrvtatdRSTtafqMGVNKVSWLLIR----FMLVMAPVVLF------INGFTKG-DWAEAFLF 341
Cdd:cd07542  190 LAVVVRTGFNTTKGQLV-------RSI----LYPKPVDFKFYRdsmkFILFLAIIALIgfiytlIILILNGeSLGEIIIR 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 342 ALSVAVGLTPEMLPmivtSTLAKGAVF----LSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKS 417
Cdd:cd07542  259 ALDIITIVVPPALP----AALTVGIIYaqsrLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDLWGVRPVSGNNF 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 418 DFVLMQA-FLNSYYQTGLKNLLDVAV----LEAVDDQIKIQKLRYKK----------LDEVPFDFDRRRMSVVVQTPQQK 482
Cdd:cd07542  335 GDLEVFSlDLDLDSSLPNGPLLRAMAtchsLTLIDGELVGDPLDLKMfeftgwsleiLRQFPFSSALQRMSVIVKTPGDD 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 483 ARMI-TKGAVEEMLKVCR-------YVEVngkVEPLTKQcevaiealtqrynrdGLRVVAVAYREFKNHQENYSVVD--- 551
Cdd:cd07542  415 SMMAfTKGAPEMIASLCKpetvpsnFQEV---LNEYTKQ---------------GFRVIALAYKALESKTWLLQKLSree 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 552 -ESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCRE---ISLNyDQVLLGGVIETLTDQQLKRA 627
Cdd:cd07542  477 vESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVAREcgmISPS-KKVILIEAVKPEDDDSASLT 555
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|
gi 446597779 628 VE---QYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGIN 664
Cdd:cd07542  556 WTlllKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGAN 595
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
191-664 8.52e-38

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 153.29  E-value: 8.52e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   191 HQFEIPIQY--LVPGDVILLSA--GDMIPADCRILSAkDLFVSQAAMTGESMPVEKFPLQKNLEETSALELDNIV----- 261
Cdd:TIGR01657  236 NGKWVTIASdeLVPGDIVSIPRpeEKTMPCDSVLLSG-SCIVNESMLTGESVPVLKFPIPDNGDDDEDLFLYETSkkhvl 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   262 FMGTNIV-------SGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFqmgvNKVSWLLIRFMLVMA-------PVVLFI 327
Cdd:TIGR01657  315 FGGTKILqirpypgDTGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKF----YKDSFKFILFLAVLAligfiytIIELIK 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   328 NGFTKGdwaEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLs 407
Cdd:TIGR01657  391 DGRPLG---KIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDL- 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   408 qhIDVQGGKSDFVLMQ---------------AFLNSYYQTGLKN-----LLDVAVLEAVD---DQIKIQKLRYKKLDEV- 463
Cdd:TIGR01657  467 --RGVQGLSGNQEFLKivtedsslkpsithkALATCHSLTKLEGklvgdPLDKKMFEATGwtlEEDDESAEPTSILAVVr 544
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   464 --------------PFDFDRRRMSVVVQTPQQKARMI-TKGAVEEMLKVCRyvevngkveplTKQCEVAIEALTQRYNRD 528
Cdd:TIGR01657  545 tddppqelsiirrfQFSSALQRMSVIVSTNDERSPDAfVKGAPETIQSLCS-----------PETVPSDYQEVLKSYTRE 613
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   529 GLRVVAVAYREF--KNHQE----NYSVVdESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCRE 602
Cdd:TIGR01657  614 GYRVLALAYKELpkLTLQKaqdlSRDAV-ESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARE 692
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   603 -------------------------------------------------------ISLNYDQVLLG---GVIETLTDQQL 624
Cdd:TIGR01657  693 cgivnpsntlilaeaeppesgkpnqikfevidsipfastqveipyplgqdsvedlLASRYHLAMSGkafAVLQAHSPELL 772
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 446597779   625 KRAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGIN 664
Cdd:TIGR01657  773 LRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGAN 812
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
194-740 5.00e-37

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 147.81  E-value: 5.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKfplqknlEETSAleldniVFMGTNIVSGS-- 271
Cdd:cd07550  112 EVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK-------REGDL------VFASTVVEEGQlv 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 272 --AQAV-----------------VLSTGIQTYFGALAHRVTAtdrsttaFQMGVNKVSWLLIRfmlvmapvvlfinGFTK 332
Cdd:cd07550  178 irAERVgretraariaelieqspSLKARIQNYAERLADRLVP-------PTLGLAGLVYALTG-------------DISR 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 333 gdwAEAFLFA-LSVAVGLTpemLPMIVTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHID 411
Cdd:cd07550  238 ---AAAVLLVdFSCGIRLS---TPVAVLSALNHAA----RHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAIIT 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 412 VQGGKS--DFVLMQAFLNSYYqtglknLLDVAvlEAVDDQIKIQKLRYKKLDEVPFdFDRRRMSVVVqtpqqKARMITKG 489
Cdd:cd07550  308 FDGRLSeeDLLYLAASAEEHF------PHPVA--RAIVREAEERGIEHPEHEEVEY-IVGHGIASTV-----DGKRIRVG 373
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 490 AVeemlkvcRYVEVNGKvePLTKQCEVAIEALTQRynrdglrvvavayrefkNHQENYSVVDESdliLIGYITFLDPPKE 569
Cdd:cd07550  374 SR-------HFMEEEEI--ILIPEVDELIEDLHAE-----------------GKSLLYVAIDGR---LIGVIGLSDPLRP 424
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 570 SAKEAVQSLHAHGV-TVKVLTGDNEFVTQKVCREisLNYDQVllggvietltdqqlkraveqyhiFAKLSPVHKERIVEQ 648
Cdd:cd07550  425 EAAEVIARLRALGGkRIIMLTGDHEQRARALAEQ--LGIDRY-----------------------HAEALPEDKAEIVEK 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 649 LKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFG 728
Cdd:cd07550  480 LQAEGRTVAFVGDGINDSPALSYADVGISMRGGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTA 559
                        570
                 ....*....|....*...
gi 446597779 729 NVFSVL------IASAFI 740
Cdd:cd07550  560 VLAGGVfgllspILAAVL 577
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
127-716 1.02e-35

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 144.37  E-value: 1.02e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 127 TIISVMvilstLLRYWQEAKSNQAA-DALKVMVS---NTATVLrhqvsaedlelmherygidtknqTTHQFE-IPIQYLV 201
Cdd:cd07552   99 TLIVIM-----LLGHWIEMKAVMGAgDALKKLAEllpKTAHLV-----------------------TDGSIEdVPVSELK 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 202 PGDVILLSAGDMIPADCRILSAKDlFVSQAAMTGESMPVEKFPLQKnleetsaleldniVFMGTNIVSGSAQAVVLSTGI 281
Cdd:cd07552  151 VGDVVLVRAGEKIPADGTILEGES-SVNESMVTGESKPVEKKPGDE-------------VIGGSVNGNGTLEVKVTKTGE 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 282 QTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTkGDWAEAFLFALSVAVGLTPEML----PMI 357
Cdd:cd07552  217 DSYLSQVMELVAQAQASKSRAENLADKVAGWLFYIALGVGIIAFIIWLIL-GDLAFALERAVTVLVIACPHALglaiPLV 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 358 VTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVL-MQAFLNSyyqtGLKN 436
Cdd:cd07552  296 VARSTSIAA----KNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEYDEDEILsLAAALEA----GSEH 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 437 LLDVAVLEAVddqiKIQKLRYKKLDEVpfdfdrrrmsvvvqtpqqkaRMITKGAVEEMLKVCRYVEVNGKVepLTKQCEV 516
Cdd:cd07552  368 PLAQAIVSAA----KEKGIRPVEVENF--------------------ENIPGVGVEGTVNGKRYQVVSPKY--LKELGLK 421
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 517 AIEALTQRYNRDGLRVVAVAyrefkNHQEnysvvdesdliLIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVT 596
Cdd:cd07552  422 YDEELVKRLAQQGNTVSFLI-----QDGE-----------VIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVA 485
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 597 QKVCREisLNYDQVllggvietltdqqlkraveqyhiFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGI 676
Cdd:cd07552  486 QAVAEE--LGIDEY-----------------------FAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGI 540
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|
gi 446597779 677 SVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANML 716
Cdd:cd07552  541 AIGAGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMK 580
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
191-664 1.95e-33

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 138.67  E-value: 1.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 191 HQFEIPIQYLVPGDV--ILLSAGD-MIPADCRILSAKdLFVSQAAMTGESMPVEKFPLqKNLEETSALELDN-----IVF 262
Cdd:cd07543   95 KWVPISSDELLPGDLvsIGRSAEDnLVPCDLLLLRGS-CIVNEAMLTGESVPLMKEPI-EDRDPEDVLDDDGddklhVLF 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 263 MGTNIVS-------------GSAQAVVLSTGIQTYFGAL-------AHRVTATDRSTTAFqmgvnkvswllIRFMLVMAP 322
Cdd:cd07543  173 GGTKVVQhtppgkgglkppdGGCLAYVLRTGFETSQGKLlrtilfsTERVTANNLETFIF-----------ILFLLVFAI 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 323 VV---LFINGfTKGDWAEAFLFaLSVAVGLT---PEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKT 396
Cdd:cd07543  242 AAaayVWIEG-TKDGRSRYKLF-LECTLILTsvvPPELPMELSLAVNTSLIALAKLYIFCTEPFRIPFAGKVDICCFDKT 319
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 397 GTLTQDKI------------FLSQHIDVQGGKSDFVLMQAFLNSYYQTG--LKNLLDVAVLEAVD------DQI---KIQ 453
Cdd:cd07543  320 GTLTSDDLvvegvaglndgkEVIPVSSIEPVETILVLASCHSLVKLDDGklVGDPLEKATLEAVDwtltkdEKVfprSKK 399
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 454 KLRYKKLDEVPFDFDRRRMSVVVQ----TPQQKARMIT-KGAVE---EMLKVC--RYVEVNgkvepltkqcevaiealtQ 523
Cdd:cd07543  400 TKGLKIIQRFHFSSALKRMSVVASykdpGSTDLKYIVAvKGAPEtlkSMLSDVpaDYDEVY------------------K 461
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 524 RYNRDGLRVVAVAYREFKNH-QENYSVVD----ESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQK 598
Cdd:cd07543  462 EYTRQGSRVLALGYKELGHLtKQQARDYKredvESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACH 541
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446597779 599 VCREISLNYDQVLLGGVIETLTDQQLKrAVEQYHIFAKLSPVHKERIVEQLKANGHVVGFLGDGIN 664
Cdd:cd07543  542 VAKELGIVDKPVLILILSEEGKSNEWK-LIPHVKVFARVAPKQKEFIITTLKELGYVTLMCGDGTN 606
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
200-746 7.57e-33

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 136.57  E-value: 7.57e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 200 LVPGDVILLSA-GDMIPADCRILSAKdLFVSQAAMTGESMPVEKFPLQKN-------LEETSALeldNIVFMGTNIVS-- 269
Cdd:cd02082  105 IVPGDIVLIKRrEVTLPCDCVLLEGS-CIVTEAMLTGESVPIGKCQIPTDshddvlfKYESSKS---HTLFQGTQVMQii 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 270 ----GSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLfINGfTKGDWAEAFLF--AL 343
Cdd:cd02082  181 ppedDILKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKFTLLLATLALIGFLYTL-IRL-LDIELPPLFIAfeFL 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 344 SVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLsqhIDVQG--------- 414
Cdd:cd02082  259 DILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDL---IGYQLkgqnqtfdp 335
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 415 -------GKSDFVLMQAFLNSYYQ---TGLKNLLDVAVLEAVDDQI-----------KIQKLRYKKLDEVPFDFDRRRMS 473
Cdd:cd02082  336 iqcqdpnNISIEHKLFAICHSLTKingKLLGDPLDVKMAEASTWDLdydheakqhysKSGTKRFYIIQVFQFHSALQRMS 415
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 474 VVvqtpqqkARMITKGAVEemlkVCRYVEVNG---KVEPLTKQCEVAIEALTQRYNRDGLRVVAVAYREF--KNHQENYS 548
Cdd:cd02082  416 VV-------AKEVDMITKD----FKHYAFIKGapeKIQSLFSHVPSDEKAQLSTLINEGYRVLALGYKELpqSEIDAFLD 484
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 549 V---VDESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCRE--ISLNYDQVLlggVIETLTDQQ 623
Cdd:cd02082  485 LsreAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQEleIINRKNPTI---IIHLLIPEI 561
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 624 LKRAVEQYH------IFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVdTAVDiAKESADLILLEKS 697
Cdd:cd02082  562 QKDNSTQWIliihtnVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISL-AEAD-ASFASPFTSKSTS 639
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446597779 698 LMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVL----IASAFIPFLPML 746
Cdd:cd02082  640 ISCVKRVILEGRVNLSTSVEIFKGYALVALIRYLSFLtlyyFYSSYSSSGQMD 692
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
194-711 4.33e-30

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 126.98  E-value: 4.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKFPLQKnleetsaleldniVFMGTNIVSGSAQ 273
Cdd:cd07551  125 EVPVEELQIGDRVQVRPGERVPADGVILSGSSS-IDEASITGESIPVEKTPGDE-------------VFAGTINGSGALT 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 274 AVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMAPVVLFINGFTKG-DWAEAFLFALSVAVGLTPE 352
Cdd:cd07551  191 VRVTKLSSDTVFAKIVQLVEEAQSEKSPTQSFIERFERIYVKGVLLAVLLLLLLPPFLLGwTWADSFYRAMVFLVVASPC 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 353 MLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIdVQGGKSDFVLMQAFLNSYYQT 432
Cdd:cd07551  271 ALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVI-PAEGVDEEELLQVAAAAESQS 349
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 433 glKNLLDVAVLEAVDDQIkIQKLRYKKLDEVPfdfdrrrmsvvvqtpQQKARMITKGAVEEMLKVCRYVEVNGkvepltk 512
Cdd:cd07551  350 --EHPLAQAIVRYAEERG-IPRLPAIEVEAVT---------------GKGVTATVDGQTYRIGKPGFFGEVGI------- 404
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 513 qcEVAIEALTQRYNRDGLRVVAVAyrefKNHQenysvvdesdliLIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGDN 592
Cdd:cd07551  405 --PSEAAALAAELESEGKTVVYVA----RDDQ------------VVGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDN 466
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 593 EFVTQKVCREISLnyDQVllggvietltdqqlkraveqyhiFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAA 672
Cdd:cd07551  467 ERTAEAVAKELGI--DEV-----------------------VANLLPEDKVAIIRELQQEYGTVAMVGDGINDAPALANA 521
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 446597779 673 DIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRT 711
Cdd:cd07551  522 DVGIAMGAGTDVALETADVVLMKDDLSKLPYAIRLSRKM 560
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
125-715 6.68e-26

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 113.65  E-value: 6.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 125 GSTIISVMVIL----STLLRYWQEAKSNQAADALKVMVSNTATVLRHqvsaedlelmherygidtknqtTHQFEIPIQYL 200
Cdd:cd07546   60 GATAEAAMVLLlflvGELLEGYAASRARSGVKALMALVPETALREEN----------------------GERREVPADSL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 201 VPGDVILLSAGDMIPADCRILSAKDLFvSQAAMTGESMPVEKFPLQKnleetsaleldniVFMGTNIVSGSAQAVVLSTG 280
Cdd:cd07546  118 RPGDVIEVAPGGRLPADGELLSGFASF-DESALTGESIPVEKAAGDK-------------VFAGSINVDGVLRIRVTSAP 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 281 IQTYFGALAHRVT-ATDRSttafqmgvnkvswllirfmlvmAPVVLFINGFTKgdWAEAFLFALSVAVGLTPEML----- 354
Cdd:cd07546  184 GDNAIDRILHLIEeAEERR----------------------APIERFIDRFSR--WYTPAIMAVALLVIVVPPLLfgadw 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 355 -----------------------PMIVTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHID 411
Cdd:cd07546  240 qtwiyrglallligcpcalvistPAAITSGLAAAA----RRGALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTDVVP 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 412 VQGGKSDFVLMQAflnSYYQTGLKNLLDVAVL-EAVDDQIkiqklrykkldEVPFDFDRRRMSvvvqtpqqkARMITKGA 490
Cdd:cd07546  316 LTGISEAELLALA---AAVEMGSSHPLAQAIVaRAQAAGL-----------TIPPAEEARALV---------GRGIEGQV 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 491 VEEMLKVCRYVEVNGKVEPLTKQcevAIEALTQrynrDGlRVVAVayrefknhqenysVVDESDLIliGYITFLDPPKES 570
Cdd:cd07546  373 DGERVLIGAPKFAADRGTLEVQG---RIAALEQ----AG-KTVVV-------------VLANGRVL--GLIALRDELRPD 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 571 AKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDqvllggvietltdqqlkraveqyhifAKLSPVHKERIVEQLK 650
Cdd:cd07546  430 AAEAVAELNALGIKALMLTGDNPRAAAAIAAELGLDFR--------------------------AGLLPEDKVKAVRELA 483
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597779 651 ANGHVVgFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANM 715
Cdd:cd07546  484 QHGPVA-MVGDGINDAPAMKAASIGIAMGSGTDVALETADAALTHNRLGGVAAMIELSRATLANI 547
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
122-717 8.40e-25

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 110.20  E-value: 8.40e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 122 DLTGSTIISVMVILSTLLRYWQEAKS----NQAADALKVMVSNTAtvlRHQVSAedleLMHERYGIDTKNQTTHQFEIPI 197
Cdd:cd07545   39 NFDMKTLMTIAVIGAALIGEWPEAAMvvflFAISEALEAYSMDRA---RRSIRS----LMDIAPKTALVRRDGQEREVPV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 198 QYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQAVVL 277
Cdd:cd07545  112 AEVAVGDRMIVRPGERIAMDGIIVRGESS-VNQAAITGESLPVEKGV-------------GDEVFAGTLNGEGALEVRVT 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 278 STGIQTYFGALAHRVTATDRSTTAFQMGVNkvswlliRFMLVMAPVVLFING--------FTKGDWAEAFLFALSVAVGL 349
Cdd:cd07545  178 KPAEDSTIARIIHLVEEAQAERAPTQAFVD-------RFARYYTPVVMAIAAlvaivpplFFGGAWFTWIYRGLALLVVA 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 350 TPEML----PMIVTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVL-MQA 424
Cdd:cd07545  251 CPCALvistPVSIVSAIGNAA----RKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLGGQTEKELLaIAA 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 425 FLNSYYQTGLKNlldvAVLE-AVDDQIKIQKLRykkldevpfDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYVEV 503
Cdd:cd07545  327 ALEYRSEHPLAS----AIVKkAEQRGLTLSAVE---------EFTALTGRGVRGVVNGTTYYIGSPRLFEELNLSESPAL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 504 NGKVEPLTKQCEVAIEALT-QRYnrdgLRVVAVAyrefknhqenysvvdesdliligyitflDPPKESAKEAVQSLHAHG 582
Cdd:cd07545  394 EAKLDALQNQGKTVMILGDgERI----LGVIAVA----------------------------DQVRPSSRNAIAALHQLG 441
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 583 VTVKV-LTGDNEFVTQKVCREIslnydqvllgGVIEtltdqqlkraveqyhIFAKLSPVHKERIVEQLKANGHVVGFLGD 661
Cdd:cd07545  442 IKQTVmLTGDNPQTAQAIAAQV----------GVSD---------------IRAELLPQDKLDAIEALQAEGGRVAMVGD 496
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446597779 662 GINDAAAIRAADIGISVDTA-VDIAKESADLILLEKSLMVLEKGVIEGRRTfANMLK 717
Cdd:cd07545  497 GVNDAPALAAADVGIAMGAAgTDTALETADIALMGDDLRKLPFAVRLSRKT-LAIIK 552
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
185-741 1.15e-20

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 97.20  E-value: 1.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 185 TKNQTTHQFEIPIQY--LVPGDVILLSAGDMIPADCRILSAKdLFVSQAAMTGESMPVEKFPlqknleetsalelDNIVF 262
Cdd:cd07553  129 TEIETGSGSRIKTRAdqIKSGDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPRIVER-------------GDKVP 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 263 MGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLVMApvVLFINGFTKGDWAEAFLFA 342
Cdd:cd07553  195 AGTSLENQAFEIRVEHSLAESWSGSILQKVEAQEARKTPRDLLADKIIHYFTVIALLIA--VAGFGVWLAIDLSIALKVF 272
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 343 LSVAVGLTPEMLPMIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQdkiflsqhidvqgGKSDFVLM 422
Cdd:cd07553  273 TSVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTR-------------GKSSFVMV 339
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 423 QAflnsyyqTGLKNLLDVAVleavddqikiqklrykkldevpfdfdrrrMSVVVQTPQQKARMITKGAVEE---MLKVCR 499
Cdd:cd07553  340 NP-------EGIDRLALRAI-----------------------------SAIEAHSRHPISRAIREHLMAKgliKAGASE 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 500 YVEVNGKvepltkqcevAIEAltqryNRDGLRVVAVAYREFKNHQENYSVVdESDLILIGYITFLDPPKESAKEAVQSLH 579
Cdd:cd07553  384 LVEIVGK----------GVSG-----NSSGSLWKLGSAPDACGIQESGVVI-ARDGRQLLDLSFNDLLRPDSNREIEELK 447
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 580 AHGVTVKVLTGDNEFVTQKVCREISLNYDQVllggvietltdqqlkraveqyhiFAKLSPVHKERIVEQLKANGHVVgfL 659
Cdd:cd07553  448 KGGLSIAILSGDNEEKVRLVGDSLGLDPRQL-----------------------FGNLSPEEKLAWIESHSPENTLM--V 502
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 660 GDGINDAAAIRAADIGISVDTAVDIAKESADLILLE------KSLMVLEKGVIEG-RRTFANMLKY-IKMTASSNFGNVf 731
Cdd:cd07553  503 GDGANDALALASAFVGIAVAGEVGVSLEAADIYYAGngiggiRDLLTLSKQTIKAiKGLFAFSLLYnLVAIGLALSGWI- 581
                        570
                 ....*....|
gi 446597779 732 SVLIASAFIP 741
Cdd:cd07553  582 SPLVAAILMP 591
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
194-741 1.16e-20

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 97.01  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDLFvSQAAMTGESMPVEKFPlqknleetsaleldnivfmGTNIVSGSAQ 273
Cdd:cd07544  122 EVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTATL-DESSLTGESKPVSKRP-------------------GDRVMSGAVN 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 274 A------VVLSTGIQTYFGALAHRVTATDRSTTAFQMgvnkvswLLIRFMLVMAPVVLFING---FTKGDwAEAFLFALS 344
Cdd:cd07544  182 GdsaltmVATKLAADSQYAGIVRLVKEAQANPAPFVR-------LADRYAVPFTLLALAIAGvawAVSGD-PVRFAAVLV 253
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 345 VAvglTPemLPMIVTSTLA--KGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGGKSDFVLM 422
Cdd:cd07544  254 VA---TP--CPLILAAPVAivSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDVVPAPGVDADEVLR 328
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 423 QAflnSYYQTGLKNLLDVAVLEAVDDQiKIQKLRYKKLDEVPfdfdrrrmsvvvqtpqqkARMITkGAVEEmlkvcRYVE 502
Cdd:cd07544  329 LA---ASVEQYSSHVLARAIVAAARER-ELQLSAVTELTEVP------------------GAGVT-GTVDG-----HEVK 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 503 VnGKVEPLTKQCEVAIEalTQRYNRDGLRVVAvayrefknhqenySVVDEsdliLIGYITFLDPPKESAKEAVQSLHAHG 582
Cdd:cd07544  381 V-GKLKFVLARGAWAPD--IRNRPLGGTAVYV-------------SVDGK----YAGAITLRDEVRPEAKETLAHLRKAG 440
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 583 VT-VKVLTGDNEFVTQKVCREISLnyDQVLlggvietltdqqlkraveqyhifAKLSPVHKERIVEQLKANGHVVgFLGD 661
Cdd:cd07544  441 VErLVMLTGDRRSVAEYIASEVGI--DEVR-----------------------AELLPEDKLAAVKEAPKAGPTI-MVGD 494
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 662 GINDAAAIRAADIGISV-DTAVDIAKESADLILLEKSLMVLEKGVIEGRRT--FANMLKYIKMTASsnfgnVFSVLIASA 738
Cdd:cd07544  495 GVNDAPALAAADVGIAMgARGSTAASEAADVVILVDDLDRVVDAVAIARRTrrIALQSVLIGMALS-----IIGMLIAAF 569

                 ....
gi 446597779 739 -FIP 741
Cdd:cd07544  570 gLIP 573
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
742-910 4.40e-19

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 85.75  E-value: 4.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  742 FLPMLPIHLLIQNLLYDVS-QIVIPFDNVDEELIAKPQRWQPE-----EVGRFMVVFGPISSIFDMITFGLMWFVFSANT 815
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLpALALGFEPPEPDLMKRPPRKPKEplfsrKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  816 PEHqtlFQSGWFMVGLLTQTLIVHMIRTAQIPFIQ--SRAATPLLIMTAVIMCIGIFLPMGP-LASYLKLQALPLSYFLY 892
Cdd:pfam00689  81 SQN---AQTMAFNTLVLSQLFNALNARSLRRSLFKigLFSNKLLLLAILLSLLLQLLIIYVPpLQAVFGTTPLSLEQWLI 157
                         170
                  ....*....|....*...
gi 446597779  893 LPVILGAYMCVTQWVKKI 910
Cdd:pfam00689 158 VLLLALVVLLVVELRKLL 175
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
125-714 6.39e-19

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 91.98  E-value: 6.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 125 GSTIISVMVILSTL----LRYWQEAKSNQAADALKVMVSNTATVLRHQVSAEdlelmherygidtknqtthqfeIPIQYL 200
Cdd:PRK11033 204 GATAEAAMVLLLFLigerLEGYAASRARRGVSALMALVPETATRLRDGEREE----------------------VAIADL 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 201 VPGDVILLSAGDMIPADCRILSAkdlFVS--QAAMTGESMPVEKFPLQKnleetsaleldniVFMGTNIVSGSAQAVVLS 278
Cdd:PRK11033 262 RPGDVIEVAAGGRLPADGKLLSP---FASfdESALTGESIPVERATGEK-------------VPAGATSVDRLVTLEVLS 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 279 TGiqtyfGAlahrvTATDRSTTafqmgvnkvswlLI------RfmlvmAPVVLFINGFTKgdWAEAFLFALSVAVGLTPE 352
Cdd:PRK11033 326 EP-----GA-----SAIDRILH------------LIeeaeerR-----APIERFIDRFSR--IYTPAIMLVALLVILVPP 376
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 353 ML----------------------------PMIVTSTLAKGAvflsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKI 404
Cdd:PRK11033 377 LLfaapwqewiyrgltllligcpcalvistPAAITSGLAAAA----RRGALIKGGAALEQLGRVTTVAFDKTGTLTEGKP 452
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 405 FLSQHIDVQGGKSDFVLMQAflnSYYQTGLKNLLDVAVleavddqikIQKLRYKKLDeVPFDFDRRRMsvvvqtpqqkAR 484
Cdd:PRK11033 453 QVTDIHPATGISESELLALA---AAVEQGSTHPLAQAI---------VREAQVRGLA-IPEAESQRAL----------AG 509
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 485 MITKGAVE-EMLKVCryveVNGKVEPLTKQCEVAIEALTQRynrdGLRVVAVAYREfknhqenysvvdesdlILIGYITF 563
Cdd:PRK11033 510 SGIEGQVNgERVLIC----APGKLPPLADAFAGQINELESA----GKTVVLVLRND----------------DVLGLIAL 565
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 564 LDPPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDqvllggvietltdqqlkraveqyhifAKLSPVHKE 643
Cdd:PRK11033 566 QDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGIDFR--------------------------AGLLPEDKV 619
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446597779 644 RIVEQLKANgHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFAN 714
Cdd:PRK11033 620 KAVTELNQH-APLAMVGDGINDAPAMKAASIGIAMGSGTDVALETADAALTHNRLRGLAQMIELSRATHAN 689
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
195-698 8.54e-19

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 91.26  E-value: 8.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 195 IPIQYLVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVekfplqknleetsALELDNIVFMGTNIVSGSaqa 274
Cdd:cd02092  140 VPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPV-------------TVAPGDLVQAGAMNLSGP--- 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 275 vvlstgiqtyfgaLAHRVTATDRSTTAFQM---------GVNKVSWLLIRFMLVMAPVV------LFIN-GFTKGDWAEA 338
Cdd:cd02092  203 -------------LRLRATAAGDDTLLAEIarlmeaaeqGRSRYVRLADRAARLYAPVVhllallTFVGwVAAGGDWRHA 269
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 339 FLFALSV-------AVGLTpemLPMIvtSTLAKGAVFlsKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHID 411
Cdd:cd02092  270 LLIAVAVliitcpcALGLA---VPAV--QVVASGRLF--RRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHA 342
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 412 VQGGksdfvlmqaflnsyyqtglknLLDVAvleavddqikiqklrykkldevpfdfdrRRMSVVVQTPQQKARMITKGAV 491
Cdd:cd02092  343 ISAD---------------------LLALA----------------------------AALAQASRHPLSRALAAAAGAR 373
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 492 EEMLKVCRyvEVNGKvepltkQCEVAIEALTQRYNRDGLRVVAVayrefknhqenySVVDESDLIL------IGYITFLD 565
Cdd:cd02092  374 PVELDDAR--EVPGR------GVEGRIDGARVRLGRPAWLGASA------------GVSTASELALskggeeAARFPFED 433
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 566 PPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREIslnydqvllggvietltdqqlkrAVEQYHifAKLSPVHKERI 645
Cdd:cd02092  434 RPRPDAREAISALRALGLSVEILSGDREPAVRALARAL-----------------------GIEDWR--AGLTPAEKVAR 488
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446597779 646 VEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSL 698
Cdd:cd02092  489 IEELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASAVDASRSAADIVFLGDSL 541
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
126-766 1.47e-17

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 87.63  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  126 STIISVMVILSTLLRYWQEAKSNQAADALKVMVSNT-ATVLRHQVSAEDlelmherygidtknqtthqfeIPIQYLVPGD 204
Cdd:TIGR01497  70 TGILFITVLFANFAEAVAEGRGKAQADSLKGTKKTTfAKLLRDDGAIDK---------------------VPADQLKKGD 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  205 VILLSAGDMIPADCRILSAKdLFVSQAAMTGESMPVEKFPLQKNLEETSaleldnivfmGTNIVSGSAQAVVLSTGIQTY 284
Cdd:TIGR01497 129 IVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIKESGGDFASVTG----------GTRILSDWLVVECTANPGETF 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  285 FGALAHRVTATDRSTTAFQMGVNKV-SWLLIRFMLVMAPVVLFIngfTKGDWAEAFLFALSVAVGLTPEMLPMIVTSTLA 363
Cdd:TIGR01497 198 LDRMIALVEGAQRRKTPNEIALTILlIALTLVFLLVTATLWPFA---AYGGNAISVTVLVALLVCLIPTTIGGLLSAIGI 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  364 KGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGgksdfvlmqaflnsyyqTGLKNLLDVAVL 443
Cdd:TIGR01497 275 AGMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTITLGNRLASEFIPAQG-----------------VDEKTLADAAQL 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  444 EAVDDQ---------------IKIQKLRYKKLDEVPFDfDRRRMSvvvQTPQQKARMITKGAVEemlKVCRYVEVNGKVe 508
Cdd:TIGR01497 338 ASLADDtpegksivilakqlgIREDDVQSLHATFVEFT-AQTRMS---GINLDNGRMIRKGAVD---AIKRHVEANGGH- 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  509 pLTKQCEVAIEALTQRynrdGLRVVAVayrefknhqenysVVDESdliLIGYITFLDPPKESAKEAVQSLHAHGVTVKVL 588
Cdd:TIGR01497 410 -IPTDLDQAVDQVARQ----GGTPLVV-------------CEDNR---IYGVIYLKDIVKGGIKERFAQLRKMGIKTIMI 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  589 TGDNEFVTQKVCREislnydqvllGGVIETLtdqqlkraveqyhifAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAA 668
Cdd:TIGR01497 469 TGDNRLTAAAIAAE----------AGVDDFI---------------AEATPEDKIALIRQEQAEGKLVAMTGDGTNDAPA 523
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  669 IRAADIGISVDTAVDIAKESADLILLE----KSLMVLEKG----VIEGRRT---FAN-MLKYIK---------------- 720
Cdd:TIGR01497 524 LAQADVGVAMNSGTQAAKEAANMVDLDsdptKLIEVVHIGkqllITRGALTtfsIANdVAKYFAiipaifaaaypqlqal 603
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446597779  721 --MTASSNFGNVFSVLIASAF-IPFL-----------PMLPIHLLIQNLL-YDVSQIVIPF 766
Cdd:TIGR01497 604 niMCLHSPDSAILSALIFNALiIPALiplalkgvsyrPLTASALLRRNLWiYGLGGLIVPF 664
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
200-746 1.92e-17

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 87.06  E-value: 1.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 200 LVPGDVILLSAGDMIPADCRILSAKDLfVSQAAMTGESMPVEKfplqknleeTSALELDNIVfMGTNIVSGSAQAVVLST 279
Cdd:PRK14010 123 LKKGHIVRVATGEQIPNDGKVIKGLAT-VDESAITGESAPVIK---------ESGGDFDNVI-GGTSVASDWLEVEITSE 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 280 GIQTYFGALAHRVTATDRSTTAFQMGV----NKVSWLLIRFMLVMAPVVLFINGftkgDWAEAFLFALSVAvgLTPEMLP 355
Cdd:PRK14010 192 PGHSFLDKMIGLVEGATRKKTPNEIALftllMTLTIIFLVVILTMYPLAKFLNF----NLSIAMLIALAVC--LIPTTIG 265
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 356 MIVTSTLAKGAVFLSKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQggksdfvlmqaflNSYYQTGLK 435
Cdd:PRK14010 266 GLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYGNRMADAFIPVK-------------SSSFERLVK 332
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 436 NLLDVAVLEAVDDQIKIQKLRYKKLDEVPFD-------FDRRRMSVVvqtpQQKARMITKGAVEEMLKvcRYVEVNGKVE 508
Cdd:PRK14010 333 AAYESSIADDTPEGRSIVKLAYKQHIDLPQEvgeyipfTAETRMSGV----KFTTREVYKGAPNSMVK--RVKEAGGHIP 406
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 509 PltkqcevAIEALTQRYNRDGLRVVavayrefknhqenysVVDESDLILiGYITFLDPPKESAKEAVQSLHAHGVTVKVL 588
Cdd:PRK14010 407 V-------DLDALVKGVSKKGGTPL---------------VVLEDNEIL-GVIYLKDVIKDGLVERFRELREMGIETVMC 463
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 589 TGDNEFVTQKVCREISLNydqvllggvietltdqqlkraveqyHIFAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAA 668
Cdd:PRK14010 464 TGDNELTAATIAKEAGVD-------------------------RFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPA 518
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446597779 669 IRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANMLKYIKMTASSNFGNVFSVLIAsAFIPFLPML 746
Cdd:PRK14010 519 LAEANVGLAMNSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAILPA-MFMAAMPAM 595
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
194-591 4.92e-17

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 86.07  E-value: 4.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 194 EIPIQYLVPGDVILLSAGDMIPADCRILSAKDL----FVSQAAMTGES-----MPVEKFPLQKNLEETSALE-------- 256
Cdd:cd02073   95 KKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPdglcYVETANLDGETnlkirQALPETALLLSEEDLARFSgeieceqp 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 257 ---LDNivFMGTNIVSGSAQ----------------------AVVLSTGIQTYF----GALAHRVTATDRSTTAFqmgvn 307
Cdd:cd02073  175 nndLYT--FNGTLELNGGRElplspdnlllrgctlrntewvyGVVVYTGHETKLmlnsGGTPLKRSSIEKKMNRF----- 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 308 kVSWLLIrFMLVMA------------------PVVLFINGFTKgdwAEAFLFALSVAVGLTPEMLP--MIVTSTLAK--G 365
Cdd:cd02073  248 -IIAIFC-ILIVMClisaigkgiwlskhgrdlWYLLPKEERSP---ALEFFFDFLTFIILYNNLIPisLYVTIEVVKflQ 322
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 366 AVFL----------SKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDK-IFLSQHIDvqGGKSDFVLMQAFLNS------ 428
Cdd:cd02073  323 SFFInwdldmydeeTDTPAEARTSNLNEELGQVEYIFSDKTGTLTENImEFKKCSIN--GVDYGFFLALALCHTvvpekd 400
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 429 ------YYQ----------TGLKNLlDVAVLE----AVDDQIKIQKLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITK 488
Cdd:cd02073  401 dhpgqlVYQasspdeaalvEAARDL-GFVFLSrtpdTVTINALGEEEEYEILHILEFNSDRKRMSVIVRDPDGRILLYCK 479
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 489 GAVEEMLKVCRyvevnGKVEPLTKQCEVAIEAltqrYNRDGLRVVAVAYRE---------FKNHQENYSVVD-------- 551
Cdd:cd02073  480 GADSVIFERLS-----PSSLELVEKTQEHLED----FASEGLRTLCLAYREiseeeyeewNEKYDEASTALQnreellde 550
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 446597779 552 -----ESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKVLTGD 591
Cdd:cd02073  551 vaeeiEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGD 595
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
202-711 1.28e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 84.21  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 202 PGDVILLSAGDMIPADCRILSAKDlFVSQAAMTGESMPVEKFPlqknleetsaleldnivfmGTNIVSGSaqaVVLStgi 281
Cdd:cd07548  129 IGDIIVVKPGEKIPLDGVVLKGES-FLDTSALTGESVPVEVKE-------------------GSSVLAGF---INLN--- 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 282 qtyfGALAHRVTATDRSTTafqmgVNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALSVAVgLTPEMLPMIVTST 361
Cdd:cd07548  183 ----GVLEIKVTKPFKDSA-----VAKILELVENASARKAPTEKFITKFARYYTPIVVFLALLLAV-IPPLFSPDGSFSD 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 362 -LAKGAVFL-----------------------SKKKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDkIFLSQHIDVQGG-- 415
Cdd:cd07548  253 wIYRALVFLviscpcalvisiplgyfggigaaSRKGILIKGSNYLEALSQVKTVVFDKTGTLTKG-VFKVTEIVPAPGfs 331
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 416 KSDFVLMQAFLNSYYQTglknlldvavleavddqikiqklrykkldevPFdfdrrrmsvvvqtpqqkARMITKgAVEEML 495
Cdd:cd07548  332 KEELLKLAALAESNSNH-------------------------------PI-----------------ARSIQK-AYGKMI 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 496 ---KVCRYVEVNGK-VEPLTKQCEVAI--EALTQRYN------RDGLRVVAVAYrefknhqenysvvdesDLILIGYITF 563
Cdd:cd07548  363 dpsEIEDYEEIAGHgIRAVVDGKEILVgnEKLMEKFNiehdedEIEGTIVHVAL----------------DGKYVGYIVI 426
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 564 LDPPKESAKEAVQSLHAHGVT-VKVLTGDNEFVTQKVCREISLNydqvllggvietltdqqlkraveqyHIFAKLSPVHK 642
Cdd:cd07548  427 SDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGID-------------------------EVYAELLPEDK 481
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446597779 643 ERIVEQLKAN-GHVVGFLGDGINDAAAIRAADIGISV-DTAVDIAKESADLILLEKSLMVLEKGVIEGRRT 711
Cdd:cd07548  482 VEKVEELKAEsKGKVAFVGDGINDAPVLARADVGIAMgGLGSDAAIEAADVVLMNDEPSKVAEAIKIARKT 552
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
144-766 5.82e-16

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 82.31  E-value: 5.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 144 EAKSNQAADALKVMVSNT-ATVLRHQVSAEDlelmherygidtknqtthqfeIPIQYLVPGDVILLSAGDMIPADCRIL- 221
Cdd:cd02078   78 EGRGKAQADSLRKTKTETqAKRLRNDGKIEK---------------------VPATDLKKGDIVLVEAGDIIPADGEVIe 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 222 -SAKdlfVSQAAMTGESMPVekfpLQKNLEETSAleldniVFMGTNIVSGSAQAVVLSTGIQTYFGALAHRVTATDRSTT 300
Cdd:cd02078  137 gVAS---VDESAITGESAPV----IRESGGDRSS------VTGGTKVLSDRIKVRITANPGETFLDRMIALVEGASRQKT 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 301 AFQMGVNK-VSWLLIRFMLVMAPVVLFINgFTKGDWAEAFLFALSVAvgLTPE----MLPMIVTSTLAKgavfLSKKKVI 375
Cdd:cd02078  204 PNEIALTIlLVGLTLIFLIVVATLPPFAE-YSGAPVSVTVLVALLVC--LIPTtiggLLSAIGIAGMDR----LLRFNVI 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 376 VKRLDAIQNFGAMDVLCTDKTGTLTQDKIFLSQHIDVQGgksdfvlmqaflnsyyqTGLKNLLDVAVLEAVDDQ------ 449
Cdd:cd02078  277 AKSGRAVEAAGDVDTLLLDKTGTITLGNRQATEFIPVGG-----------------VDEKELADAAQLASLADEtpegrs 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 450 -IKIQKLRYKKLDE--------VPFDfDRRRMSVVvqtPQQKARMITKGAVEEMLKvcrYVEVNGKVEPltkqceVAIEA 520
Cdd:cd02078  340 iVILAKQLGGTERDldlsgaefIPFS-AETRMSGV---DLPDGTEIRKGAVDAIRK---YVRSLGGSIP------EELEA 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 521 LTQRYNRDGLRVVAVAyrefkNHQENYSVVDESDLIligyitfldppKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVC 600
Cdd:cd02078  407 IVEEISKQGGTPLVVA-----EDDRVLGVIYLKDII-----------KPGIKERFAELRKMGIKTVMITGDNPLTAAAIA 470
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 601 REislnydqvllGGVIETLtdqqlkraveqyhifAKLSPVHKERIVEQLKANGHVVGFLGDGINDAAAIRAADIGISVDT 680
Cdd:cd02078  471 AE----------AGVDDFL---------------AEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAMNS 525
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 681 AVDIAKESADLILLE----KSLMVLE--KGVIEGR---RTF--AN-MLKYIK------------------MTASSNFGNV 730
Cdd:cd02078  526 GTQAAKEAGNMVDLDsdptKLIEVVEigKQLLMTRgalTTFsiANdVAKYFAiipamfaaaypqlgalniMHLASPYSAI 605
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 446597779 731 FSVLIASAF-IPFL-----------PMLPIHLLIQNLL-YDVSQIVIPF 766
Cdd:cd02078  606 LSAVIFNALiIPALiplalkgvkyrPLSASALLRRNLLiYGLGGIIVPF 654
copA PRK10671
copper-exporting P-type ATPase CopA;
194-715 8.07e-16

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 82.10  E-value: 8.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 194 EIPIQYLVPGDVILLSAGDMIPADCRILSAkDLFVSQAAMTGESMPVEKFPlqknleetsalelDNIVFMGTNIVSGSAQ 273
Cdd:PRK10671 335 SVPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGE-------------GDSVHAGTVVQDGSVL 400
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 274 AVVLSTGIQTYFGALAHRVTATDRSTTAFQMGVNKVSwllirfmLVMAPVVLFINGFTKGDW-----AEAFLFALSV--- 345
Cdd:PRK10671 401 FRASAVGSHTTLSRIIRMVRQAQSSKPEIGQLADKIS-------AVFVPVVVVIALVSAAIWyffgpAPQIVYTLVIatt 473
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 346 --------AVGLTPemlPMIVTSTLAKGAVFlskkKVIVKRLDAIQNFGAMDVLCTDKTGTLTQDKiflSQHIDVQ---G 414
Cdd:PRK10671 474 vliiacpcALGLAT---PMSIISGVGRAAEF----GVLVRDADALQRASTLDTLVFDKTGTLTEGK---PQVVAVKtfnG 543
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 415 GKSDFVLMQAflnSYYQTGLKNLLDVAVLEAVDDQikiqklrykKLDEVpfdfdrrrmsvvvqtpqqkarmitkgaveEM 494
Cdd:PRK10671 544 VDEAQALRLA---AALEQGSSHPLARAILDKAGDM---------TLPQV-----------------------------NG 582
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 495 LKVCRYVEVNGKVE---------PLTKQCEVAIEALTQRYNRDGLRVVAvayrefknhqenySVVDESDLILIGYITFLD 565
Cdd:PRK10671 583 FRTLRGLGVSGEAEghalllgnqALLNEQQVDTKALEAEITAQASQGAT-------------PVLLAVDGKAAALLAIRD 649
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 566 PPKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLnyDQVLlGGVIetltdqqlkraveqyhifaklsPVHKERI 645
Cdd:PRK10671 650 PLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI--DEVI-AGVL----------------------PDGKAEA 704
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 646 VEQLKANGHVVGFLGDGINDAAAIRAADIGISVDTAVDIAKESADLILLEKSLMVLEKGVIEGRRTFANM 715
Cdd:PRK10671 705 IKRLQSQGRQVAMVGDGINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNM 774
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
203-626 5.72e-14

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 76.10  E-value: 5.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 203 GDVILLSAGDMIPADCRILSAKD----LFVSQAAMTGES---------------------------------MPVEKFPL 245
Cdd:cd07536  104 GDIVIVEKNQRIPSDMVLLRTSEpqgsCYVETAQLDGETdlklrvavsctqqlpalgdlmkisayvecqkpqMDIHSFEG 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 246 QKNLEETS-----ALELDNIVFMGTNIV-SGSAQAVVLSTGIQTyfgALAHRVTATDRSTTAFQMGVNKVSWLLIRFMLV 319
Cdd:cd07536  184 NFTLEDSDppiheSLSIENTLLRASTLRnTGWVIGVVVYTGKET---KLVMNTSNAKNKVGLLDLELNRLTKALFLALVV 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 320 MAPVVLFINGFTK-----GDWAEAFLFALSVAVGLTP--------EMLP--MIVTSTLAKG--AVFLSKKKVI------- 375
Cdd:cd07536  261 LSLVMVTLQGFWGpwygeKNWYIKKMDTTSDNFGRNLlrflllfsYIIPisLRVNLDMVKAvyAWFIMWDENMyyigndt 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 376 --VKRLDAI-QNFGAMDVLCTDKTGTLTQDK-IFLSQHID--VQGGksdfvlmqaflnsyyqtglknlldvavleavddq 449
Cdd:cd07536  341 gtVARTSTIpEELGQVVYLLTDKTGTLTQNEmIFKRCHIGgvSYGG---------------------------------- 386
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 450 ikiQKLRYKKLDEVPFDFDRRRMSVVVQTPQQ-KARMITKGAVEEMLKVCRyvevngkVEPLTKQCEVAIEaltqRYNRD 528
Cdd:cd07536  387 ---QVLSFCILQLLEFTSDRKRMSVIVRDESTgEITLYMKGADVAISPIVS-------KDSYMEQYNDWLE----EECGE 452
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 529 GLRVVAVAYREF-KNHQENYSVVD---------------------ESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVK 586
Cdd:cd07536  453 GLRTLCVAKKALtENEYQEWESRYteaslslhdrslrvaevveslERELELLGLTAIEDRLQAGVPETIETLRKAGIKIW 532
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 446597779 587 VLTGDN-EFVTQ--KVCREISLNYDQVLLGGVIETLTDQQLKR 626
Cdd:cd07536  533 MLTGDKqETAICiaKSCHLVSRTQDIHLLRQDTSRGERAAITQ 575
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
185-591 1.86e-12

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 71.64  E-value: 1.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   185 TKNQTTHQF-------EIPIQYLVPGDVILLSAGDMIPADCRILSAKD----LFVSQAAMTGES-------------MPV 240
Cdd:TIGR01652   82 VNNRLTEVLeghgqfvEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEpdgvCYVETANLDGETnlklrqaleetqkMLD 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   241 EK------------------FPLQKNLE----ETSALELDNIVFMGTNIV-SGSAQAVVLSTGIQTyfgALAHRVTATDR 297
Cdd:TIGR01652  162 EDdiknfsgeieceqpnaslYSFQGNMTingdRQYPLSPDNILLRGCTLRnTDWVIGVVVYTGHDT---KLMRNATQAPS 238
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   298 STTAFQMGVNKVSWLLIRFMLVMAPVVLFINGF----------------TKGDWAEAFLFALSVAVGLTPEMLP--MIVT 359
Cdd:TIGR01652  239 KRSRLEKELNFLIIILFCLLFVLCLISSVGAGIwndahgkdlwyirldvSERNAAANGFFSFLTFLILFSSLIPisLYVS 318
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   360 STLAK--------GAVFLSKKKVI----VKRLDAIQNFGAMDVLCTDKTGTLTQDKI-FLSQHI---------------- 410
Cdd:TIGR01652  319 LELVKsvqayfinSDLQMYHEKTDtpasVRTSNLNEELGQVEYIFSDKTGTLTQNIMeFKKCSIagvsygdgfteikdgi 398
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   411 ------DVQGGKS-----------DFVLMQAFLNSYYQTGLKN--LLDVAVLEAV------DDQIKI------------- 452
Cdd:TIGR01652  399 rerlgsYVENENSmlveskgftfvDPRLVDLLKTNKPNAKRINefFLALALCHTVvpefndDGPEEItyqaaspdeaalv 478
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   453 --------------------------QKLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRYvEVNGK 506
Cdd:TIGR01652  479 kaardvgfvffertpksislliemhgETKEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFKRLSS-GGNQV 557
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779   507 VEPLTKQCEvaiealtqRYNRDGLRVVAVAYR-----EFKNHQENY--------------SVVDES---DLILIGYITFL 564
Cdd:TIGR01652  558 NEETKEHLE--------NYASEGLRTLCIAYRelseeEYEEWNEEYneastaltdreeklDVVAESiekDLILLGATAIE 629
                          570       580
                   ....*....|....*....|....*..
gi 446597779   565 DPPKESAKEAVQSLHAHGVTVKVLTGD 591
Cdd:TIGR01652  630 DKLQEGVPETIELLRQAGIKIWVLTGD 656
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
439-501 2.13e-12

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 63.78  E-value: 2.13e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446597779  439 DVAVLEAVDD-QIKIQKLR--YKKLDEVPFDFDRRRMSVVVQTP-QQKARMITKGAVEEMLKVCRYV 501
Cdd:pfam13246  25 ESALLVFAEKmGIDVEELRkdYPRVAEIPFNSDRKRMSTVHKLPdDGKYRLFVKGAPEIILDRCTTI 91
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
173-591 4.17e-10

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 63.58  E-value: 4.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 173 DLELMHERYGIDTKNQtthqfEIPIQYLVPGDVILLSAGDMIPADCRILSAKD----LFVSQAAMTGES----------- 237
Cdd:cd07541   77 DKEQNYEKLTVRGETV-----EIPSSDIKVGDLIIVEKNQRIPADMVLLRTSEksgsCFIRTDQLDGETdwklriavpct 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 238 --MPVE-----------------------KFPLQKNLEETSaLELDNIVFMGTNIVSGSAQAVVLSTGIQTYfgalahrv 292
Cdd:cd07541  152 qkLPEEgilnsisavyaeapqkdihsfygTFTINDDPTSES-LSVENTLWANTVVASGTVIGVVVYTGKETR-------- 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 293 TATDRSTTAFQMG-----VNKVSWLLIRFMLVMAPVVLFINGFTKGDWAEAFLFALsvavgLTPEMLPMIVTSTLAKGAV 367
Cdd:cd07541  223 SVMNTSQPKNKVGlldleINFLTKILFCAVLALSIVMVALQGFQGPWYIYLFRFLI-----LFSSIIPISLRVNLDMAKI 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 368 FLSKK--------KVIVKRLDAIQNFGAMDVLCTDKTGTLTQ-DKIFLSQHIDVQGgksdfvlmqaflnsyyqtglknll 438
Cdd:cd07541  298 VYSWQiehdknipGTVVRTSTIPEELGRIEYLLSDKTGTLTQnEMVFKKLHLGTVS------------------------ 353
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 439 dvavleavddqIKIQKLRYKKLDEVPFDFDRRRMSVVVQTPQQ-KARMITKGAVEEMLKVCRYVEVngkvepLTKQCeva 517
Cdd:cd07541  354 -----------YGGQNLNYEILQIFPFTSESKRMGIIVREEKTgEITFYMKGADVVMSKIVQYNDW------LEEEC--- 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 518 iealtQRYNRDGLRVVAVA--------YREFKN--HQENYSVVD------------ESDLILIGYITFLDPPKESAKEAV 575
Cdd:cd07541  414 -----GNMAREGLRTLVVAkkklseeeYQAFEKryNAAKLSIHDrdlkvaevveslERELELLCLTGVEDKLQEDVKPTL 488
                        490
                 ....*....|....*.
gi 446597779 576 QSLHAHGVTVKVLTGD 591
Cdd:cd07541  489 ELLRNAGIKIWMLTGD 504
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
57-106 9.01e-08

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 49.87  E-value: 9.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446597779   57 DLLKQFDTHLT-GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPF 106
Cdd:pfam00690   8 EVLKKLGTDLEkGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPL 58
PLN03190 PLN03190
aminophospholipid translocase; Provisional
450-636 1.82e-07

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 55.29  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  450 IKIQKLRYKKLDEVPFDFDRRRMSVVVQTPQQKARMITKGAVEEMLKVCRyvevngkvEPLTKQCEVAIEALTQRYNRDG 529
Cdd:PLN03190  596 IHGERQRFNVLGLHEFDSDRKRMSVILGCPDKTVKVFVKGADTSMFSVID--------RSLNMNVIRATEAHLHTYSSLG 667
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  530 LRVVAVAYREFKNHQ--------ENYSVV--------------DESDLILIGYITFLDPPKESAKEAVQSLHAHGVTVKV 587
Cdd:PLN03190  668 LRTLVVGMRELNDSEfeqwhfsfEAASTAligraallrkvasnVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWV 747
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 446597779  588 LTGDNEFVTqkvcreISLNYDQVLLGG-----VIETLTDQQLKRAVEQYHIFAK 636
Cdd:PLN03190  748 LTGDKQETA------ISIGYSSKLLTNkmtqiIINSNSKESCRKSLEDALVMSK 795
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
557-665 5.02e-07

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 51.05  E-value: 5.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779  557 LIGYITFLDP--PKESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNYDQVLLGGVIEtltdqqlkraveqyHIF 634
Cdd:pfam00702  87 LLGVIALADElkLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDD--------------VGV 152
                          90       100       110
                  ....*....|....*....|....*....|.
gi 446597779  635 AKLSPVHKERIVEQLKANGHVVGFLGDGIND 665
Cdd:pfam00702 153 GKPKPEIYLAALERLGVKPEEVLMVGDGVND 183
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
56-107 5.37e-05

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 42.18  E-value: 5.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 446597779    56 NDLLKQFDTHLT-GLTEEQAHTQQMTVGLNEVTHEKPLTWWQHLWYCYRNPFN 107
Cdd:smart00831  10 EEVLERLQTDLEkGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLI 62
SerB COG0560
Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is ...
569-664 3.03e-03

Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 440326 [Multi-domain]  Cd Length: 221  Bit Score: 40.21  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597779 569 ESAKEAVQSLHAHGVTVKVLTGDNEFVTQKVCREISLNY---------DQVLLGGVIETLTDQQLK-RAVEQyhiFAKLS 638
Cdd:COG0560   91 PGARELIAEHRAAGHKVAIVSGGFTFFVEPIAERLGIDHvianeleveDGRLTGEVVGPIVDGEGKaEALRE---LAAEL 167
                         90       100
                 ....*....|....*....|....*.
gi 446597779 639 PVHKERIVeqlkanghvvgFLGDGIN 664
Cdd:COG0560  168 GIDLEQSY-----------AYGDSAN 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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