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Conserved domains on  [gi|446601412|ref|WP_000678758|]
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MULTISPECIES: MFS transporter [Bacillus]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 9-400 7.88e-69

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 222.49  E-value: 7.88e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   9 FHKLWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFL 88
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  89 SVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT 168
Cdd:cd06173   80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELV-PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 169 GSFTVDAVTYFVCFMFVLIISKFKPHTEGSLKDVNvksiYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIF 248
Cdd:cd06173  159 GAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL----LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 249 LYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVtglAFIPIMGYMGTVYGIVAASIIHGMGE 328
Cdd:cd06173  235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG---LALLVLGLSPSLWLLLAALFLLGLAG 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446601412 329 GVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:cd06173  312 GLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 9-400 7.88e-69

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 222.49  E-value: 7.88e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   9 FHKLWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFL 88
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  89 SVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT 168
Cdd:cd06173   80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELV-PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 169 GSFTVDAVTYFVCFMFVLIISKFKPHTEGSLKDVNvksiYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIF 248
Cdd:cd06173  159 GAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL----LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 249 LYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVtglAFIPIMGYMGTVYGIVAASIIHGMGE 328
Cdd:cd06173  235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG---LALLVLGLSPSLWLLLAALFLLGLAG 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446601412 329 GVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:cd06173  312 GLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-365 2.32e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.05  E-value: 2.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLSVF 91
Cdd:COG2814   15 LALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTvtniiTFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:COG2814   94 LAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 172 TVDAVTYFVCFmfvLIISKFKPHTEGSLKdvnvksiyQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYK 251
Cdd:COG2814  168 LVNAVLALLAL---LLLLRLLPESRPAAR--------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 252 VMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAfipIMGYMGTVYGIVAASIIHGMGEGVF 331
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL---LLALAGSLWLLLLALFLLGFGFGLL 313

                        330       340       350
                 ....*....|....*....|....*....|....
gi 446601412 332 GPYAATIRQLASPNHMLGRVNAVQRTLNWGAWAL 365
Cdd:COG2814  314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 9-413 6.88e-21

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 94.43  E-value: 6.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412    9 FHKLWLGQSISLLGTQFTIVALPlFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFL 88
Cdd:pfam05977  12 FRVIWIASLASNLGTLMQDVAAS-WLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVST 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   89 SVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT 168
Cdd:pfam05977  91 LLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVP-RRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  169 GSFTVDAVtyfvCFMFVL-IISKFKPHTEGSlkDVNVKSIYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVI 247
Cdd:pfam05977 170 FTFALNAL----SYFAVIaALWRWKRAAPAS--PLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  248 FLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSA---AVSVTGLAFIPimgymgTVYGIVAASIIH 324
Cdd:pfam05977 244 VARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASvvtALVLLSLALAP------NLWLAIPVLLLG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  325 GMGE-GVFGPYAATIrQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRRGVS 403
Cdd:pfam05977 318 GAAWiTALTTLNVAV-QLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFRLP 396

                         410
                  ....*....|
gi 446601412  404 KGNEIEYTSS 413
Cdd:pfam05977 397 EGEAADLIPS 406
PRK10489 PRK10489
enterobactin transporter EntS;
6-398 1.37e-12

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 68.85  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   6 HFNFHKLWLGQSISLLGTQFTIVALPLfALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLI----CSL 81
Cdd:PRK10489  16 HPAFRAVFIARFISIFGLGLLGVAVPV-QIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLargtCGL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  82 CQGVLFLSVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPeivtdKDHLKKGNAQLALSESLSIVIGPMLAGIV 161
Cdd:PRK10489  95 GFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVG-----RENLMQAGAITMLTVRLGSVISPALGGLL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 162 ITLVGLTGSFTVDAVTYFVCFMFVLIISKFKPHTEgslkdvNVKSIYQNIYEGLVYFKKHPVLEPIvtcgAVYGFFKYIL 241
Cdd:PRK10489 170 IAAGGVAWNYGLAAAGTFITLLPLLRLPALPPPPQ------PREHPLRSLLAGFRFLLASPVVGGI----ALLGGLLTMA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 242 NSILVIF---LYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGYMGTVygiV 318
Cdd:PRK10489 240 SAVRVLYpalADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILA---V 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 319 AASIIHGMGEGVFGPYAATIRQLASPNHMLGRVNAVqrtlnWGAW-----ALGSFASAFLISIFGLQTTLFIGGFGTTLC 393
Cdd:PRK10489 317 LCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGL-----WTAQnvtgdAIGAALLGGLGAMMTPVASASASGFGLLII 391


                 ....*
gi 446601412 394 LVALL 398
Cdd:PRK10489 392 GVLLL 396
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 9-400 7.88e-69

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 222.49  E-value: 7.88e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   9 FHKLWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFL 88
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  89 SVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT 168
Cdd:cd06173   80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELV-PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 169 GSFTVDAVTYFVCFMFVLIISKFKPHTEGSLKDVNvksiYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIF 248
Cdd:cd06173  159 GAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL----LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 249 LYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVtglAFIPIMGYMGTVYGIVAASIIHGMGE 328
Cdd:cd06173  235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG---LALLVLGLSPSLWLLLAALFLLGLAG 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446601412 329 GVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:cd06173  312 GLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-365 2.32e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.05  E-value: 2.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLSVF 91
Cdd:COG2814   15 LALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTvtniiTFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:COG2814   94 LAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 172 TVDAVTYFVCFmfvLIISKFKPHTEGSLKdvnvksiyQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYK 251
Cdd:COG2814  168 LVNAVLALLAL---LLLLRLLPESRPAAR--------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 252 VMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAfipIMGYMGTVYGIVAASIIHGMGEGVF 331
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL---LLALAGSLWLLLLALFLLGFGFGLL 313

                        330       340       350
                 ....*....|....*....|....*....|....
gi 446601412 332 GPYAATIRQLASPNHMLGRVNAVQRTLNWGAWAL 365
Cdd:COG2814  314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 9-413 6.88e-21

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 94.43  E-value: 6.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412    9 FHKLWLGQSISLLGTQFTIVALPlFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFL 88
Cdd:pfam05977  12 FRVIWIASLASNLGTLMQDVAAS-WLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVST 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   89 SVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT 168
Cdd:pfam05977  91 LLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVP-RRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  169 GSFTVDAVtyfvCFMFVL-IISKFKPHTEGSlkDVNVKSIYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVI 247
Cdd:pfam05977 170 FTFALNAL----SYFAVIaALWRWKRAAPAS--PLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  248 FLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSA---AVSVTGLAFIPimgymgTVYGIVAASIIH 324
Cdd:pfam05977 244 VARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASvvtALVLLSLALAP------NLWLAIPVLLLG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  325 GMGE-GVFGPYAATIrQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRRGVS 403
Cdd:pfam05977 318 GAAWiTALTTLNVAV-QLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFRLP 396

                         410
                  ....*....|
gi 446601412  404 KGNEIEYTSS 413
Cdd:pfam05977 397 EGEAADLIPS 406
MFS_1 pfam07690
Major Facilitator Superfamily;
12-367 2.22e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 91.33  E-value: 2.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   12 LWLGQSISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLFLSVF 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI-----GLLLFALG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   92 ILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:pfam07690  76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  172 TVDAVTYFVCFMFVLiiskFKPHTEGSLKDVNVKSIYQNIYEGLVYFKKHPVLEPIVtcGAVYGFFKYILNSILVIFLYK 251
Cdd:pfam07690 155 LILAILSLLAAVLLL----LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL--ALLLFGFAFFGLLTYLPLYQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  252 VMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGYMGTVYGIVAASIIHGMGEGVF 331
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 446601412  332 GPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGS 367
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 12-400 7.27e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 90.33  E-value: 7.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLFLSVF 91
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLL-----GLLLLAVS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:cd17325   75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP-PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 172 TVDAVTYFVCFMFVLIISK--FKPHTEGSLKDVNVKSIYQNIyeglvyfKKHPVLEPIVTCGAVYGFFKYILNSILVIFL 249
Cdd:cd17325  154 LVCAALALLALVLALLLLPepRPPPNKRAVSAARLRSGLRLL-------LRDRRLLALFLAIFVLAFAFGALEPFLPLYA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 250 YKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPimgYMGTVYGIVAASIIHGMGEG 329
Cdd:cd17325  227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP---LATSFWLLLLLLALLGLGLG 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446601412 330 VFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:cd17325  304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
PRK10489 PRK10489
enterobactin transporter EntS;
6-398 1.37e-12

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 68.85  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   6 HFNFHKLWLGQSISLLGTQFTIVALPLfALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLI----CSL 81
Cdd:PRK10489  16 HPAFRAVFIARFISIFGLGLLGVAVPV-QIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLargtCGL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  82 CQGVLFLSVFILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPeivtdKDHLKKGNAQLALSESLSIVIGPMLAGIV 161
Cdd:PRK10489  95 GFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVG-----RENLMQAGAITMLTVRLGSVISPALGGLL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 162 ITLVGLTGSFTVDAVTYFVCFMFVLIISKFKPHTEgslkdvNVKSIYQNIYEGLVYFKKHPVLEPIvtcgAVYGFFKYIL 241
Cdd:PRK10489 170 IAAGGVAWNYGLAAAGTFITLLPLLRLPALPPPPQ------PREHPLRSLLAGFRFLLASPVVGGI----ALLGGLLTMA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 242 NSILVIF---LYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGYMGTVygiV 318
Cdd:PRK10489 240 SAVRVLYpalADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILA---V 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 319 AASIIHGMGEGVFGPYAATIRQLASPNHMLGRVNAVqrtlnWGAW-----ALGSFASAFLISIFGLQTTLFIGGFGTTLC 393
Cdd:PRK10489 317 LCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGL-----WTAQnvtgdAIGAALLGGLGAMMTPVASASASGFGLLII 391


                 ....*
gi 446601412 394 LVALL 398
Cdd:PRK10489 392 GVLLL 396
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 13-388 1.42e-12

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 68.44  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  13 WLGQSISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIF-VPYLIFGLVA---GALIDIFHRKNVLLICSLcqGVLFL 88
Cdd:cd17391    2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFsSTFLVSAIFSpiwGRLADRYGRKPMLLRASL--GMAIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  89 SVFILTVTNIitfPLLVFIMFLNGIFTTFYNIAIPsfLPEIVTDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT 168
Cdd:cd17391   80 IGLMAFVTNV---WQLLILRLLQGVFSGYVPNATA--LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 169 GSFTVDAVTYFVCFMFVL--IISKFKPHTEGslKDVNVKSIYQNIyeglvyfKKHPVLEPIVTCGAVYGFFKYILNSILV 246
Cdd:cd17391  155 NVFFITGGLLFLAFLLTLffVKEDFKPVEKK--KMVSTKEVWNSV-------PNPSLLISLFVTTFIIQLANQSIEPILT 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 247 IFLYKVM----NLSEIEiGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVtgLAFIPiMGYMGTVYGIVAASI 322
Cdd:cd17391  226 LYIRQLMgdasNLAFIS-GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA--LLYIP-QAFVQTPWQLGILRF 301

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446601412 323 IHGMGEGVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGF 388
Cdd:cd17391  302 LLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTAL 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 35-398 2.78e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.76  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  35 LEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLFLSVFILTVTNIITFPLLVFIMFLNGIF 114
Cdd:cd06174   23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLL-----GLLLFALGALLFAFAPSFWLLLLGRFLLGLG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 115 TTFYNIAIPSFLPEiVTDKDHLKKGNAQLALSESLSIVIGPMLAGIVIT--LVGLTGSFTVDAVTYFVCFMFVLIIskFK 192
Cdd:cd06174   98 SGLIDPAVLALIAD-LFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLV--VP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 193 PHTEGSLKDVNVKSIYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFkYILNSILVIFLYKVMNLSEIEIGFVIGSAAVGFL 272
Cdd:cd06174  175 DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAY-YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 273 IGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIpiMGYMGTVYGIVAASIIHGMGEGVFGPYAATIRQLASPNHMLGRVN 352
Cdd:cd06174  254 LGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL--LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 446601412 353 AVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALL 398
Cdd:cd06174  332 GLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 57-400 2.97e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 64.56  E-value: 2.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  57 LIFGLVAGALIDIFHRKNVLLICSLCQGVLFLSVFILTvtniiTFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTDKdHL 136
Cdd:cd17329   49 IVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH-----SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPE-NR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 137 KKGNAQLALSESLSIVIGPMLAGIVITLvGLTGSFTVDAVTYFVCFMFVLIisKFKPHTEGSLKDvnvksIYQNIYEGLV 216
Cdd:cd17329  123 TRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLF--LLPETRPKRRAA-----EKTEILRGYK 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 217 YFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAA 296
Cdd:cd17329  195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 297 VSVTGLAFIPIMGymgTVYGIVAASIIHGMGEGVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISI 376
Cdd:cd17329  275 LFAIGFAVLAFAN---TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351

                        330       340
                 ....*....|....*....|....
gi 446601412 377 FGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:cd17329  352 LGPGLPWLILAALGLIAAALLLGL 375
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 18-400 1.30e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 62.59  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  18 ISLLGTQFTIVALPLFAlEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVlfLSVFILTVTN 97
Cdd:cd17474   10 LAVLGVSIVDPILPAIA-EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI--GGLLCGLSDS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  98 iitFPLLVFIMFLNGifttfynIAIPSFLPEIVTDKDHLKKGNAQ------LALSESLSIVIGPMLAGivitLVGLTGSF 171
Cdd:cd17474   87 ---FALLLAGRALQG-------IGAAGLGPLALTLIGDLFEGGERakamglYEAALGLGIAVGPLLGG----LLAAISWR 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 172 TVDAVTYFVCFMFVLIISKFKPHTEGSlkdvnVKSIYQNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYK 251
Cdd:cd17474  153 YPFFLLAALIPVAFLAILFLLPEPKEK-----AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 252 VMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVsVTGLAFIpIMGYMGTVYGIVAASIIHGMGEGVF 331
Cdd:cd17474  228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLL-LYALSLL-LLGFVPSLALLLIAIVLFGLGLGLN 305

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446601412 332 GPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:cd17474  306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-166 3.45e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 61.46  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  11 KLWLGQSISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLSV 90
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  91 FILTVTNIitfPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQ-------LALSESLSIVIGPMLAGIVIT 163
Cdd:COG2211  312 FFLGPGNL---WLLLVLAALAGIGLGAILVLPWAMLADVV-DYDEWKTGRRReglyfgiFTFAIKLGQALAGALAGLLLA 387


                 ...
gi 446601412 164 LVG 166
Cdd:COG2211  388 LFG 390
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
36-398 3.62e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 61.02  E-value: 3.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  36 EVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLFLSVFILTVTNIITFPLLVFIMFLNGIFT 115
Cdd:COG0738   36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL-----GLLLMALGLLLFALAPSYPLLLLALFLLGLGL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 116 TFYNIAIPSFLPEIVTdkdhlKKGNAQLALSE---SLSIVIGPMLAGIVITL---VGLTGSFTVDAVTYFVCFMFVLIIS 189
Cdd:COG0738  111 GLLDVAANPYVAALGP-----ETAASRLNLLHaffSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 190 KFKPHTEGSLKDVNVKSiyqniyegLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYKVMNLSEIEIGFVIGSAAV 269
Cdd:COG0738  186 LPEIEEEEEEAAGSAAS--------LKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 270 GFLIG---NTILMKKsqqINNAKMLIYSAAVSVTGLA-FIPIMGYMGTVYGIVAAsiihGMGEGVFGP--YAATIRQLas 343
Cdd:COG0738  258 GMTIGrflGGFLLKR---FGPVRLLRLSALLAAVGLLlALLAPGPWLALIGLALV----GLGLSLMFPtiFSLALDGL-- 328

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446601412 344 PNHMLGRVNAVQRTLNWGAwALGSFASAFLISIFGLQTTLFIggfgTTLCLVALL 398
Cdd:COG0738  329 GKRTAAAVSAVLIMGIVGG-AIGPPLIGFLADAFGLRAAFLV----PLVCYLLIL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-399 4.70e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.65  E-value: 4.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLFLSVF 91
Cdd:COG2271   15 LFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI-----GLLLWGLA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTDKdHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:COG2271   89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 172 TVDAVTYFVCFMFVLIIskfkphtegslkdvnvksiyqniyeglvyfkkhpvlepIVTCGAVYGFFKYILNSILVIFLYK 251
Cdd:COG2271  168 LILGLPGLLLALLRFWL--------------------------------------LALAYFLVYFALYGFLTWLPTYLVE 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 252 VMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIpIMGYMGTVYGIVAASIIHGMG-EGV 330
Cdd:COG2271  210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL-LLALLPSPALAIALLFLAGFGlGGA 288

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446601412 331 FGPYAATIRQLAsPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLR 399
Cdd:COG2271  289 FGLLWALAAELF-PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 29-399 4.06e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.97  E-value: 4.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  29 ALPLFAlEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICslcQGVLFLSVFILTVTNiiTFPLLVFIM 108
Cdd:cd17320   21 ALPAIA-RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAG---LLLFILASLLCALAS--SIEQLLIAR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 109 FLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFVCF-MFVLI 187
Cdd:cd17320   95 FLQGLGAAAGSVVARAIVRDLY-SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLlLVLLF 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 188 ISKFKPHTEGSLKDVNVKSIYQNIyeglvyFKKHPVLEPIVTCGAVYGFFkYILNSILVIFLYKVMNLSEIEIGFVIGSA 267
Cdd:cd17320  174 LPETLPEEKRKPLLSSLLRAYKRV------LKNRRFLGYALALGLSFAGL-FAYLAAAPFIYIEQLGLSPAQFGLLFALN 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 268 AVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGY--MGTVYGIVAASIIHGMGEGVFGPYAATIrQLASPN 345
Cdd:cd17320  247 AIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALlgGLSLWPLVAPLFLIFFGFGLIFPNATSL-ALEPFP 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446601412 346 HMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLR 399
Cdd:cd17320  326 HVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 37-398 4.38e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 58.78  E-value: 4.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   37 VLQTSEANAAMLrgiifVPYLIFGLVAGALIDIFHRKNVLLICSLCQgvLFLSVFILTVTNIITFPLLVFIMFLNGIFTT 116
Cdd:PRK08633   46 VILTAIVNALFL-----LPFLLLSSPAGFLADKFSKNRVIRIVKLFE--VGLTLLIVLAYYLGWFWLAFAVTFLLGAQSA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  117 FYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLT------GSFTVDAVTYFVCFMFVLIISK 190
Cdd:PRK08633  119 IYSPAKYGIIPELVG-KENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNtpseilGRIAPAGLVLLAVAVLGLIFAY 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  191 FKPHTEGSLKDVNVKSIY---QNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYKVMNLSE-IEIGFVIGS 266
Cdd:PRK08633  198 RLPKVPAAAPEVFDKKKYlfpKLLWRNLKLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNtFQVQYLLAA 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  267 AAVGFLIGNTILMKKSQQINNAKMLIYSAAvsvtGLA-FIPIMGYMGTVYGIVAASIIHGMGEGVFG-PYAATIrQLASP 344
Cdd:PRK08633  278 SAIGIGIGSLLAGRLSGRHIELGLVPLGAL----GLAlSLFLLPTAPSLASVLVLFFLFGFSAGLFIvPLNALI-QFRAP 352

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446601412  345 NHMLGRVNAVQRTLNWGAwALGSFASAFLISIFGLQTT---LFIGGFGTTLCLVALL 398
Cdd:PRK08633  353 EKELGKVLAANNFLQNVG-MLLFLALTTLFSGLGLSPAglfYLIALVTLIGTLYTLL 408
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 18-189 8.72e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.82  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  18 ISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLFLSVFILTVTN 97
Cdd:cd17325  210 VLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI-----GLLLSAVALLLLPL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  98 IITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVT 177
Cdd:cd17325  285 ATSFWLLLLLLALLGLGLGLVFPATLALLADIV-PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363

                        170
                 ....*....|..
gi 446601412 178 YFVCFMFVLIIS 189
Cdd:cd17325  364 LLLAAVLFLLLR 375
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 58-400 5.57e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.50  E-value: 5.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  58 IFGLVAGALIDIFHRKNVLLICSLCQGVLFLSVFILTvtniiTFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTDKDHLK 137
Cdd:cd17473   50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD-----SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAK 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 138 KGNAQLALSeSLSIVIGPMLAGIVITLvGLTGSFTVdavtYFVCFMFVLIISKFKPHTEgslkdVNVKSIYQNIYEGLVY 217
Cdd:cd17473  125 MLGLQSAAM-SLGGVVFLLLGGALAEI-GWRAPFLV----YLLALPVLILVLLFLPEPA-----RKSKSAASPGAATAAA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 218 FKKHPVLePIVTCGAVYGFFKYILNSILVIFLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAV 297
Cdd:cd17473  194 LPWKRVL-PIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 298 SVTGLAfipIMGYMGTVYGIVAASIIHGMGEGVFGPYA-ATIRQLASPNHMlGRVNAVQRTLNwgawALGSFASAFLISI 376
Cdd:cd17473  273 MALGFL---LLALASGLWVVLLGAILAGLGFGLLLPTLnSWAMSLVPPELR-GRAMGIVTSAF----FLGQFLSPLVLGP 344

                        330       340       350
                 ....*....|....*....|....*....|
gi 446601412 377 FGLQTT------LFIGGFGTTLCLVALLRR 400
Cdd:cd17473  345 LVNLTGglsgafLILGVLALVLAIVLLLLR 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
21-333 1.70e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.98  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  21 LGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVA----GALIDIFH-----RKNVLLICSLCQGVLFLSVF 91
Cdd:COG2211   20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITdpliGALSDRTRtrwgrRRPWILIGAIPLALSFVLLF 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTVTNIITFPLLVFIMF-LNGIFTTFYNIAIPSFLPEIVTDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLV----- 165
Cdd:COG2211  100 TAPDLSPTGKLIYALVTYlLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaa 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 166 -GLTGSFTVDAVTYFVCFMFVLIISKFKPHTEGSLKdvnvksiyqNIYEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSI 244
Cdd:COG2211  180 lGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV---------SLKESLKALLKNRPFLLLLLAYLLFFLALALVAAL 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 245 LVIFLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGyMGTVYGIVAASIIH 324
Cdd:COG2211  251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG-PGNLWLLLVLAALA 329


                 ....*....
gi 446601412 325 GMGEGVFGP 333
Cdd:COG2211  330 GIGLGAILV 338
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 12-395 2.65e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEvLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLsvF 91
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL--L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTVTNIitfPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:cd17489   78 YLLATSV---ALLLVLRLIHGIGWGAFTTAAATLVADII-PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 172 TVDAVTYFVCFMFVLIIS--KFKPHTEGSLKDvnvksiyqniyeglvyFKKHPVLEPIVTCGAVYGFFKYILNSILVIFL 249
Cdd:cd17489  154 IVAAVLALLALLLVFLVKdpPPVAAEEAEAGT----------------RAFRRLVEKKVLPPALILFLASIAYGAISTFL 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 250 -YKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAfipIMGYMGTVYGIVAASIIHGMGE 328
Cdd:cd17489  218 pLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLL---LLSFAGSPWMLLLAAVLYGLGF 294

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446601412 329 GVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLV 395
Cdd:cd17489  295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 12-399 1.48e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.88  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEVLQTSEAN--AAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLS 89
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  90 VFILTvtniiTFPLLVFIMFLNGIFTTfYNIAIPSFLPEIVTDKDHlKKGNAQLALSESLSIVIGPMLAGIVITLVGLTG 169
Cdd:cd17330   81 LGLSR-----NLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEER-AKAFGIISAAFGLGFILGPALGGFLSTPYGYAL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 170 SFTVDAVTYFVCFMFVLIISkfkphtegslkdvnvksiyqniyeglvyfkkhPVLEPIVTCGAVYGFFKYILNSILVIFL 249
Cdd:cd17330  154 PFLVAAALALLNLVLVLFFL--------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFL 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 250 YKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKS-QQINNAKMLIYSAAVSVTGLAFIPIMGYMGTVYgivAASIIHGMGE 328
Cdd:cd17330  202 KDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLaKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLV---LAAAILAFGT 278

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446601412 329 GVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLR 399
Cdd:cd17330  279 GIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_1 pfam07690
Major Facilitator Superfamily;
227-400 1.70e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  227 IVTCGAVYGFFKYILNSILVIFLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIp 306
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  307 imGYMGTVYGIVAASIIHGMGEGVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIG 386
Cdd:pfam07690  80 --LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170
                  ....*....|....
gi 446601412  387 GFGTTLCLVALLRR 400
Cdd:pfam07690 158 AILSLLAAVLLLLP 171
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 30-398 2.26e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.47  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  30 LPLFAlEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLcqgVLFLSVFILTVTNiiTFPLLVFIMF 109
Cdd:cd17324   22 LPDIA-RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLL---LFILGNLLAALAP--SFALLLLARA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 110 LNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFVCF-MFVLII 188
Cdd:cd17324   96 LAGLAHGGFWAIAAAYAADLV-PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAAlLLWRLL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 189 SKFKPHTEGSLKDVNvksiyqniyeGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYKVMNLSEIEIGFVIGSAA 268
Cdd:cd17324  175 PSLPPKKPGSLGLLS----------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 269 VGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGYMgtvYGIVAASIIHGMGEGVFGPyAATIRQLASPNHML 348
Cdd:cd17324  245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP---LLLLVGLVLWGLGFFAAHS-ALQTRVLRLAPEAR 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 446601412 349 GRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGfgtTLCLVALL 398
Cdd:cd17324  321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGA---ALLLLALL 367
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
253-400 4.37e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.43  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 253 MNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAfipIMGYMGTVYGIVAASIIHGMGEGVFG 332
Cdd:COG2814   40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL---LCALAPSLWLLLAARFLQGLGAGALF 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446601412 333 PYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALLRR 400
Cdd:COG2814  117 PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
30-190 5.09e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.31  E-value: 5.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  30 LPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCqGVLFLSVFILTVTNIITFPLLVFI-M 108
Cdd:COG0738  233 LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALL-AAVGLLLALLAPGPWLALIGLALVgL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 109 FLNGIFTTFYNIAIPSFlpeivtDKDHLKKGNAQLALSeSLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFVCFMFVLII 188
Cdd:COG0738  312 GLSLMFPTIFSLALDGL------GKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384


                 ..
gi 446601412 189 SK 190
Cdd:COG0738  385 KR 386
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
13-351 1.44e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.84  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  13 WLGqsISLLGTQFTIVA--LPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVA----GALIDIFHRKNVLLICSLCQGVL 86
Cdd:PRK09874  20 WLG--CFLTGAAFSLVMpfLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIAspfwGGLADRKGRKIMLLRSALGMGIV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  87 FlsVFILTVTNIITFPLLVFIMFLNGIFttfyniaIPSFLPEIVTDKDHLKKGNAQLALSES--LSIVIGPMLAGIVITL 164
Cdd:PRK09874  98 M--VLMGLAQNIWQFLILRALLGLLGGF-------VPNANALIATQVPRNKSGWALGTLSTGgvSGALLGPLAGGLLADS 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 165 VGLTGSFTVDAVTYFVCFMFVL--IISKFKPHTEGSLKDV-NVKSIYQNIYEGLVYFKKHPVLEpiVTCGAVygffkyil 241
Cdd:PRK09874 169 YGLRPVFFITASVLFLCFLVTLfcIRENFQPVSKKEMLHMrEVVTSLKNPKLVLSLFVTTLIIQ--VATGSI-------- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 242 NSILVIFLYKVM-NLSEIEI--GFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVtgLAFIPiMGYMGTVYGIV 318
Cdd:PRK09874 239 APILTLYVRELAgNVSNIAFisGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSV--LLLIP-MSFVQTPLQLG 315

                        330       340       350
                 ....*....|....*....|....*....|...
gi 446601412 319 AASIIHGMGEGVFGPYAATIRQLASPNHMLGRV 351
Cdd:PRK09874 316 ILRFLLGAADGALLPAVQTLLVYNSSNQIAGRI 348
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
5-188 1.47e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.80  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   5 KHFNFHKLWLGQSISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQG 84
Cdd:COG2223  203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  85 VLFLSVFILTvtniITFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITL 164
Cdd:COG2223  283 LGLLLLALAL----GSLWLFLVLFLLLGLALGGGNGAVFALVPDIF-PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

                        170       180
                 ....*....|....*....|....*
gi 446601412 165 VG-LTGSFTVDAVTYFVCFMFVLII 188
Cdd:COG2223  358 TGsYTAAFLVFAVLALVALVLTLLL 382
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 30-185 2.04e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.40  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  30 LPLFALEVLqTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLcqgVLFLSVFILTVTNIITFPLLVFIMF 109
Cdd:cd17477  211 LPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCAL---LGALAALLLPLVPGLPLALLVLLFL 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446601412 110 LNGIFTTFYNIAIpSFLPEIVtDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFVCFMFV 185
Cdd:cd17477  287 WGGAAGPLYTLAL-ALAGDRL-PGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 30-397 2.66e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 46.04  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  30 LPLFA--LEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLSVFILTVTNiitFPLLVFI 107
Cdd:cd17335   17 LPFLSvyLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQI---FWLLLLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 108 MFLNGIFTTfyniAIPSFLPEIVTDKDHLKKGN-AQLALSESLSIVIGPMLAGIVITLVGLTGSFTVdAVTYFVCFMF-- 184
Cdd:cd17335   94 VILGAFFSA----PVVPLVDSITLQYLGEERERyGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTI-AFYVFAVLMLla 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 185 VLIISKFKPHTEGSLKDVNVKsiyqniyEGLVYFKKHPVLEPIVTCGAVyGFFKYILNSILVIFLYKVmNLSEIEIGFVI 264
Cdd:cd17335  169 LLLALKFPFRPKHPEPNENTG-------GLLALLRNPRVLAFLLVAFLM-GFGHGLIYSFLFWHLQDL-GGSKTLIGLLW 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 265 GSAAVG----FLIGNTILmkksQQINNAKMLIYSAAVSVTGLAfipIMGYMGTVYGIVAASIIHGMGEGVFGPYAATIRQ 340
Cdd:cd17335  240 TVGVVSeipfFFFSSRLI----QRFGHVGLLYLGLLAYVVRWL---LYSFLENPWLVLPIELLHGLTFALVWAAAVSYAS 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446601412 341 LASPNHMLGRVNAVQRTLNWGA-WALGSFASAFLISIFGLQTTLFIGGFGTTLCLVAL 397
Cdd:cd17335  313 AAAPPGLRATAQGLLQGLYFGLgGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAF 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-190 3.14e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALID-IFHRKNVLLICSLCQGVLFLSV 90
Cdd:COG2271  185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrLGRRRKLVLAIGLLLAALALLL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  91 FILTVTNIITFPLLVFIMFLNGIFTTFYNIAIPSFLPeivtdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGS 170
Cdd:COG2271  265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP-----KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339

                        170       180
                 ....*....|....*....|
gi 446601412 171 FTVDAVTYFVCFMFVLIISK 190
Cdd:COG2271  340 FLLLAALALLAALLALLLLR 359
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 12-188 5.54e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.80  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  12 LWLGQSISLLGTQFTIVALPLFAlEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFLSVF 91
Cdd:COG0477   19 LALGTFLEGLDFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  92 ILTvtniiTFPLLVFIMFLNGIFTTFYNIAIPSFLPEIVTDKDHLkKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSF 171
Cdd:COG0477   98 LAP-----SPELLIAARALQGIGAGGLMPGALALIAELFPARERG-RALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171

                        170
                 ....*....|....*..
gi 446601412 172 TVDAVTYFVCFMFVLII 188
Cdd:COG0477  172 LINAPLGLLALVLRLRL 188
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
25-204 6.22e-05

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 45.34  E-value: 6.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   25 FTIVALPLFALEVLQTSEANAAM-LRGIIFV-PYLIFGLVAGALIDIFHRKNVLLICSLCQ-GVLFLSVFILTVTNIitf 101
Cdd:PRK06814   32 NALVILILYGLSGALGAYNNALVtLAGAVFIlPFFIFSALAGQLADKYDKAKLAKILKFAEiGIAALAIYGFHLNSV--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  102 PLLVFIMFLNGIFTTFYNIAIPSFLPEIVTdKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFVC 181
Cdd:PRK06814  109 PLLFAALFLMGIHSALFGPIKYSILPDHLN-KDELLGANALVEAGTFIAILLGTIIGGLATISGNFVILVALLMGIAVLG 187

                         170       180
                  ....*....|....*....|...
gi 446601412  182 FMFVLIIskfkPHTEGSLKDVNV 204
Cdd:PRK06814  188 WLASLFI----PKTGNAAPDLKI 206
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 9-188 2.21e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   9 FHKLWLGQSISLLGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLICSLCQGVLFL 88
Cdd:cd17353  215 FWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMF 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  89 sVFILTVTNIITFPLLVFIMFLN--GIFTTFyniaiPSFLPEIVTDKdHLKKGNAQLALSESLSIVIGPMLAGIVITLVG 166
Cdd:cd17353  295 -LLPFIGSVAVLFVLGVALIGFCygGGFALF-----PALTADFFGTK-NAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367

                        170       180
                 ....*....|....*....|..
gi 446601412 167 LTGSFTVDAVTYFVCFMFVLII 188
Cdd:cd17353  368 YNAAFIIAAALSLVALALALLL 389
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 21-398 3.26e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  21 LGTQFTIVALPLFALEVLQtseANAAMLrGIIFVPYLIFGLVAGALI-----DIFHRKNVLLICSLCqgvLFLSVFILTV 95
Cdd:cd17471   10 LAGAFVLPYLSLFLTEELG---ASPLQI-GIFMTLSALSGIVVSQWLgrlsdRGGDRKPLILLALLA---GALGYLLFAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  96 TNiiTFPLLVFIMFLngiFTTFYNIAIPSFLPEIVTDKDHLKKGNAQLALSE-----SLSIVIGPMLAGIVITLVGLTGS 170
Cdd:cd17471   83 LR--NYWVLLLVGVV---LLSLGAAAFPQLFALAREYADRSSGRDATLFNSVlraafSLAWVIGPPLAFLLLDVLGFTGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 171 FTVDAVTYFVCFMFVLIISKFKPHTEGSLKDVNVKsiyqniyeglvyfKKHPVLEPIVTCGAVYGFFkYILNSILVI--- 247
Cdd:cd17471  158 FLLAALLYLVVALLVLFLLPSVKPPAQKATPASSL-------------VKAPVNRRLLLLFAAFTLL-FAANSMYIIamp 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 248 -FLYKVMNLSEIEIGFVIGSAA---VGFLIGNTILMKKsqqINNAKMLIYSAavsVTGLAFIPIMGYMGTVYGIVAASII 323
Cdd:cd17471  224 lYVTNELGGSESWVGLLFGLAAaleIPIMLLAGLLAKR---FGKRRLLLAGF---LAGVLFYLGLALATSLWQLIALQLL 297

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446601412 324 HGMGEGVFGPYAATIRQLASPNHMlGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTTLFIGGFGTTLCLVALL 398
Cdd:cd17471  298 NAIFIGITAGLGISYFQDLMPGQP-GLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 143-399 2.14e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 39.89  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 143 LALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFVCFM--FVLIISKFKPHTEgSLKDVNVKSIYQNIYEGLVYFKK 220
Cdd:cd17331  127 LGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVlvILLIPSNTKSKRE-KEAKESASPPSVFNLKEILRLLR 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 221 HPVLEPIVTCGAVYGFFKYILNSILVIFLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKK-SQQINNAKMLIYSAAVSV 299
Cdd:cd17331  206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLA 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 300 TGLAFipiMGYMGTVYGIVAASIIHGMGEGVFGPYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGL 379
Cdd:cd17331  286 IGYLL---LAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF 362

                        250       260
                 ....*....|....*....|
gi 446601412 380 QTTLFIGGFGTTLCLVALLR 399
Cdd:cd17331  363 PSFGLLGAAINGLLTVYLLL 382
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 30-382 3.23e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.51  E-value: 3.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  30 LPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFH-----RKNVLLICSLCQGVLFLSVFilTVTNIITFPLL 104
Cdd:cd17332   22 LLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRsrwgrFRPWLLWGAIPLALLFVLLF--TTPDGSGTGKL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 105 VFIMFLNGIFTTFY---NIAIPSFLPEIVTDKDHLKKGNAQLALSESLSIVIGPMLAGIVITLVGLTGSFTVDAVTYFV- 180
Cdd:cd17332  100 IYALITYILLDLLYtlvNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIi 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 181 -------CFMFVLIISKFKPHTEGSLKDVNVKsiyqniyEGLVYFKKHPVLEPIVTCGAVYGFFKYILNSILVIFLYKVM 253
Cdd:cd17332  180 giigiilLLICFFGTRERVVPPEEEKSKLPLL-------KSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 254 nLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSVTGLAFIPIMGYmGTVYGIVAASIIHGMGEGVFG- 332
Cdd:cd17332  253 -GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPP-GNLVLILVLAVLAGIGYGGANl 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446601412 333 ------PYAATIRQLASPNHMLGRVNAVQRTLNWGAWALGSFASAFLISIFGLQTT 382
Cdd:cd17332  331 lpwamlADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVAN 386
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
8-397 4.75e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.09  E-value: 4.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412   8 NFHKLWLGQSISLlGTQFTIVALPLFALEVLQTSEANAAMLRGIIFVPYLIFGLVAGALIDIFHRKNVLLIcslcqGVLF 87
Cdd:COG2223    6 VLLLATLAFFLAF-GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI-----GLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412  88 LSVFILTVTNIITFPLLVFIMFLNGIFT-TFYNIAIPS----FLPEivtdkdhlKKGNAQ--LALSESLSIVIGPMLAGI 160
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALvskwFPPD--------RRGLALglAAGGGNLGAAVAAFLAPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 161 VITLVGLTGSFTVDAVTYFVCFMFVLIISKFKPHTEGSLKDVNVKSI------YQNIYEGLVYFkkhpvlepiVTCGAVY 234
Cdd:COG2223  152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQlealrdPRFWLLSLLYF---------GTFGSFI 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 235 GFfkyilNSILVIFLYKVMNLSEIEIGFVIGSAAVGFLIGNTILMKKSQQINNAKMLIYSAAVSvtGLAFIPIMGYMGTV 314
Cdd:COG2223  223 GF-----SSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM--ALGLLLLALALGSL 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601412 315 YGIVAASII----HGMGEGVFGPYAATIrqlaSPNHMLGRVNAVQRTlnwgAWALGSFASAFLISIFGLQTTLFIGGFGT 390
Cdd:COG2223  296 WLFLVLFLLlglaLGGGNGAVFALVPDI----FPTKNAGAVYGLVGA----AGGLGGFLGPLLFGALLDATGSYTAAFLV 367


                 ....*..
gi 446601412 391 TLCLVAL 397
Cdd:COG2223  368 FAVLALV 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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