|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-455 |
1.58e-130 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 387.59 E-value: 1.58e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 1 MKGSPFIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHT 80
Cdd:COG5841 1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 81 VKRVLKSGIVFMFIMGVISCFTLYMLAPHLAKLVIDGNDqtgnsvgaVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGP 160
Cdd:COG5841 81 ARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDPR--------AYYSLRALAPALLIVPVMSVLRGYFQGLQNMTP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 161 SALSVVVEQFFRVLTILIGSFvvlYVLKASVSLAVGISTFGAFMGAVGGLTVLSAYYIRRRRHLKKKEMESIPQTTKSFF 240
Cdd:COG5841 153 TAVSQVIEQIVRVIFILLLAY---LLLPYGLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSKESSK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 241 SLYKELFTYSIPFVVVGLAIPLYQTIDTFTINKLLIQIGYMQGEAEKINAII-GLVQMVVLIPVSVATAFSMSLVPEMTK 319
Cdd:COG5841 230 DILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILsGMAQPLVNLPTVLATALATSLVPAISE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 320 AYTAGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGagnDPEMGRiILQYYAPACILFSLFTVTAAMLQGI 399
Cdd:COG5841 310 AFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFG---NPEGGG-ILAILAPSAIFLSLQQVTTGILQGL 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 446601499 400 NQQQKTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSKYV 455
Cdd:COG5841 386 GKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYT 441
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
13-455 |
3.93e-129 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 380.66 E-value: 3.93e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 13 LTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRVLKSGIVFM 92
Cdd:cd13124 3 LTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLILL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 93 FIMGVISCFTLYMLAPHLAKLVIdGNDQtgnsvgaVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSALSVVVEQFFR 172
Cdd:cd13124 83 LILGLVFFLLLFFGAPFLAQLLL-GDPR-------LAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 173 VLTILIGSFVVLYVLKaSVSLAVGISTFGAFMGAVGGLTVLSAYYIRRRRHLKKKEMESiPQTTKSFFSLYKELFTYSIP 252
Cdd:cd13124 155 VIVILVLAYLLLPVGG-GLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKS-PRSKISTKEILKELLSYAIP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 253 FVVVGLAIPLYQTIDTFTINKLLIQIGYMQGEAEKINAII-GLVQMVVLIPVSVATAFSMSLVPEMTKAYTAGNTKLLYK 331
Cdd:cd13124 233 ITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILtGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 332 HFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNdpemGRIILQYYAPACILFSLFTVTAAMLQGINQQQKTVLGLVI 411
Cdd:cd13124 313 RINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLI 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 446601499 412 GIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSKYV 455
Cdd:cd13124 389 GLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLL 432
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
6-423 |
1.30e-31 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 126.25 E-value: 1.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 6 FIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRVL 85
Cdd:TIGR02900 1 FLKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 86 KSGIVFMFIMGVISCFTLYMLAPHLAKLVIDGNdqtgnsvgAVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSALSV 165
Cdd:TIGR02900 81 KVSLIFTLIWSLIVTAIVFLLSPFIASTLLKDE--------RSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 166 VVEQFFRVLTILIgsfVVLYVLKASVSLAVGISTFGAFMGAVGGLTVLSAYYIrRRRHLKKKEMESipQTTKSFFSLYKE 245
Cdd:TIGR02900 153 VIEQIVRISVVAL---LISAFLPYGLEYAVAGAYLSLVLGELVSLLYLYFFFK-RKKSFSIRFPFF--DYKSEGKALLFD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 246 LFTYSIPFVVVGLAIPLYQTIDTFTINKLLIQIGYMQGEAEK-INAIIGLVQMVVLIPVSVATAFSMSLVPEMTKAYTAG 324
Cdd:TIGR02900 227 LFSVSLPLTLSRFIGSLLYFLETLLVPQRLVIAGVTYREATSlYGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMAKK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 325 NTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAgndPEMGRIIlQYYAPACILFSLFTVTAAMLQGINQQQK 404
Cdd:TIGR02900 307 NYSSIEKRINQAIKISLLLGLITTVILLVIPDELGALFYGR---PDAGNFI-RVLAPSFPFLYFSAPLQSILQGLGKQKV 382
|
410
....*....|....*....
gi 446601499 405 TVLGLVIGIIVKIVLNIVL 423
Cdd:TIGR02900 383 ALRNSLIGAIVKIILLFVL 401
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
8-319 |
7.30e-18 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 83.51 E-value: 7.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 8 RGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYdqlNDYHTVKRVLKS 87
Cdd:pfam01943 3 KNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKY---REKYELVSLYWL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 88 GIVFMFIMGVISCFTLYMLAphlaklvidgndqTGNSVGAVTTNIRIVSFA-LILVPVMSLLRGFFQGFQSMGPSALSVV 166
Cdd:pfam01943 80 NALLVKLVLVLLFLLLPLIA-------------AFLGLPELAVLYRILALMfLLLPGVVQFRRGLFQGLERMKYALISQI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 167 VEQffrvLTILIGSFVVLYVLKASVSLAVGIStFGAFMGAVGGLTVLSAYYIRRRRHLKKKEMesipqttksffslyKEL 246
Cdd:pfam01943 147 VES----LSRVILVFIAVFLPGDIVAALLYQV-LAALVGGIIALAVLRKIFRPRFVFPSLKLV--------------RKL 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446601499 247 FTYSIPFVVVGLAIPLYQTIDTftinkllIQIGYMQGeAEKINAIIGLVQMVVLIPVSVATAFSMSLVPEMTK 319
Cdd:pfam01943 208 LSFGAPLFISSLAISLYTYIDS-------ILLGLLLG-AGAVGIYNAAYQLLVAIQGLLNPIVTAVLFPVFSK 272
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-455 |
1.58e-130 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 387.59 E-value: 1.58e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 1 MKGSPFIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHT 80
Cdd:COG5841 1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 81 VKRVLKSGIVFMFIMGVISCFTLYMLAPHLAKLVIDGNDqtgnsvgaVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGP 160
Cdd:COG5841 81 ARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDPR--------AYYSLRALAPALLIVPVMSVLRGYFQGLQNMTP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 161 SALSVVVEQFFRVLTILIGSFvvlYVLKASVSLAVGISTFGAFMGAVGGLTVLSAYYIRRRRHLKKKEMESIPQTTKSFF 240
Cdd:COG5841 153 TAVSQVIEQIVRVIFILLLAY---LLLPYGLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSKESSK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 241 SLYKELFTYSIPFVVVGLAIPLYQTIDTFTINKLLIQIGYMQGEAEKINAII-GLVQMVVLIPVSVATAFSMSLVPEMTK 319
Cdd:COG5841 230 DILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILsGMAQPLVNLPTVLATALATSLVPAISE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 320 AYTAGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGagnDPEMGRiILQYYAPACILFSLFTVTAAMLQGI 399
Cdd:COG5841 310 AFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFG---NPEGGG-ILAILAPSAIFLSLQQVTTGILQGL 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 446601499 400 NQQQKTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSKYV 455
Cdd:COG5841 386 GKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYT 441
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
13-455 |
3.93e-129 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 380.66 E-value: 3.93e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 13 LTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRVLKSGIVFM 92
Cdd:cd13124 3 LTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLILL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 93 FIMGVISCFTLYMLAPHLAKLVIdGNDQtgnsvgaVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSALSVVVEQFFR 172
Cdd:cd13124 83 LILGLVFFLLLFFGAPFLAQLLL-GDPR-------LAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 173 VLTILIGSFVVLYVLKaSVSLAVGISTFGAFMGAVGGLTVLSAYYIRRRRHLKKKEMESiPQTTKSFFSLYKELFTYSIP 252
Cdd:cd13124 155 VIVILVLAYLLLPVGG-GLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKS-PRSKISTKEILKELLSYAIP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 253 FVVVGLAIPLYQTIDTFTINKLLIQIGYMQGEAEKINAII-GLVQMVVLIPVSVATAFSMSLVPEMTKAYTAGNTKLLYK 331
Cdd:cd13124 233 ITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILtGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 332 HFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNdpemGRIILQYYAPACILFSLFTVTAAMLQGINQQQKTVLGLVI 411
Cdd:cd13124 313 RINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLI 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 446601499 412 GIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSKYV 455
Cdd:cd13124 389 GLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLL 432
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
6-452 |
1.31e-35 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 136.13 E-value: 1.31e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 6 FIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDqlndYHTVKRVL 85
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYR----KEKIREII 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 86 KSGIVFMFIMGVIScftlyMLAPHLAKLVIDGNDQTGNSVgavttnIRIVSFALILVPVMSLLRGFFQGFQSMGPSALSV 165
Cdd:cd13128 77 STSLVLKLILGILA-----LLLLFLFAFLIAFYDPELVLL------LYILALSLPFSALNSLFRGIFQGFEKMKYIVIAR 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 166 VVEQFFRVLTILIgsfvvLYVLKASVSLAVGISTFGAFMGAVggltvLSAYYIRRRRHLKKKEMESipqttksfFSLYKE 245
Cdd:cd13128 146 IIESVLSLILALI-----LVLLGGGLIGFALAYLIASVLSAI-----LLLYIYRKKILLPKFFSFD--------LKLAKE 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 246 LFTYSIPFVVVGLAIPLYQTIDTftinkllIQIGYMQGEAE--KINAIIGLVQMVVLIPVSVATAfsmsLVPEMTKAYtA 323
Cdd:cd13128 208 LLRFSIPLALSGIFSLIYTRIDT-------IMLGYFLGDAAvgIYNAAYRIAELLLFIPSAISTA----LFPRISELY-K 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 324 GNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNDPemGRIILQYYAPACILFSLFTVTAAMLQGINQQQ 403
Cdd:cd13128 276 NDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP--AALVLQILAWGFLFIFLNGIFGSILQAIGKQK 353
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 446601499 404 KTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLS 452
Cdd:cd13128 354 LTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
6-423 |
1.30e-31 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 126.25 E-value: 1.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 6 FIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRVL 85
Cdd:TIGR02900 1 FLKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 86 KSGIVFMFIMGVISCFTLYMLAPHLAKLVIDGNdqtgnsvgAVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSALSV 165
Cdd:TIGR02900 81 KVSLIFTLIWSLIVTAIVFLLSPFIASTLLKDE--------RSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 166 VVEQFFRVLTILIgsfVVLYVLKASVSLAVGISTFGAFMGAVGGLTVLSAYYIrRRRHLKKKEMESipQTTKSFFSLYKE 245
Cdd:TIGR02900 153 VIEQIVRISVVAL---LISAFLPYGLEYAVAGAYLSLVLGELVSLLYLYFFFK-RKKSFSIRFPFF--DYKSEGKALLFD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 246 LFTYSIPFVVVGLAIPLYQTIDTFTINKLLIQIGYMQGEAEK-INAIIGLVQMVVLIPVSVATAFSMSLVPEMTKAYTAG 324
Cdd:TIGR02900 227 LFSVSLPLTLSRFIGSLLYFLETLLVPQRLVIAGVTYREATSlYGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMAKK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 325 NTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAgndPEMGRIIlQYYAPACILFSLFTVTAAMLQGINQQQK 404
Cdd:TIGR02900 307 NYSSIEKRINQAIKISLLLGLITTVILLVIPDELGALFYGR---PDAGNFI-RVLAPSFPFLYFSAPLQSILQGLGKQKV 382
|
410
....*....|....*....
gi 446601499 405 TVLGLVIGIIVKIVLNIVL 423
Cdd:TIGR02900 383 ALRNSLIGAIVKIILLFVL 401
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
4-448 |
9.97e-22 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 96.17 E-value: 9.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 4 SPFIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYDQLNdyhtVKR 83
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEE----LRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 84 VLKSGIVFMFIMGVISCFTLYMLAPHLAKLVidgndqtgnSVGAVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSAL 163
Cdd:COG2244 78 LLSTALLLRLLLSLLLALLLLLLAPFIAALL---------GEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLAL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 164 SVVVEQFFRVLTIligsfVVLYVLKASVSLAVgistfgafmgavggltvlsayyirrrrhlkkkemesipqttksffsly 243
Cdd:COG2244 149 INILSSLLSLLLA-----LLLALLGLGLWGLV------------------------------------------------ 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 244 kelFTYSIPFVVVGLAIPLYQTIDTFTINKLLiqigymqgeAEKINAIIGLVQMVVLIPVSVATAFSMSLVPEMTKAYTA 323
Cdd:COG2244 176 ---LKYSLPLLLSGLLGLLLTNLDRLLLGALL---------GPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAE 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 324 GNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNDPemGRIILQYYAPACILFSLFTVTAAMLQGINQQQ 403
Cdd:COG2244 244 GDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTR 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446601499 404 KTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNL 448
Cdd:COG2244 322 LLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
7-453 |
4.61e-18 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 86.36 E-value: 4.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 7 IRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYV-LYTYAYR-PYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRV 84
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVAdAFFVAFRiPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 85 LKSGIVFMFIMGVISCFTLYMLAPHLAKLVIDGNDqtGNSVGAVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSALS 164
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGFD--PEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 165 VVveqFFRVLTILIGSFVVLYVLKASVSLAVGISTFGAFMGAVGGLTVLSA-YYIRRRRHLKKKEMesipqttksffsly 243
Cdd:COG0728 159 PV---LLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLgLRLRPRFDLRDPGV-------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 244 KELFTYSIPFVVVGLAIPLYQTIDTFTINKLliqigymqgeAEKINAIIGLVQMVVLIPVSV-ATAFSMSLVPEMTKAYT 322
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFL----------PEGSVSALYYADRLYQLPLGLfGVAIGTALLPRLSRAAA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 323 AGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGN----DPEMGRIILQYYAPACILFSLFTVTAAMLQG 398
Cdd:COG0728 292 AGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAftaeDTALTALALAAYALGLPAFALVKVLARAFYA 371
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 446601499 399 INQQQKTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSK 453
Cdd:COG0728 372 RQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRR 426
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
8-319 |
7.30e-18 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 83.51 E-value: 7.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 8 RGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYdqlNDYHTVKRVLKS 87
Cdd:pfam01943 3 KNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKY---REKYELVSLYWL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 88 GIVFMFIMGVISCFTLYMLAphlaklvidgndqTGNSVGAVTTNIRIVSFA-LILVPVMSLLRGFFQGFQSMGPSALSVV 166
Cdd:pfam01943 80 NALLVKLVLVLLFLLLPLIA-------------AFLGLPELAVLYRILALMfLLLPGVVQFRRGLFQGLERMKYALISQI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 167 VEQffrvLTILIGSFVVLYVLKASVSLAVGIStFGAFMGAVGGLTVLSAYYIRRRRHLKKKEMesipqttksffslyKEL 246
Cdd:pfam01943 147 VES----LSRVILVFIAVFLPGDIVAALLYQV-LAALVGGIIALAVLRKIFRPRFVFPSLKLV--------------RKL 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446601499 247 FTYSIPFVVVGLAIPLYQTIDTftinkllIQIGYMQGeAEKINAIIGLVQMVVLIPVSVATAFSMSLVPEMTK 319
Cdd:pfam01943 208 LSFGAPLFISSLAISLYTYIDS-------ILLGLLLG-AGAVGIYNAAYQLLVAIQGLLNPIVTAVLFPVFSK 272
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
16-453 |
5.84e-16 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 79.42 E-value: 5.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 16 ATMISKMLGFIYVIPFTAMVGTSGYV-LYTYAYR-PYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRVLKSGIVFMF 93
Cdd:cd13123 3 GTLLSRILGFVRDVLIAAAFGAGPLAdAFFVAFRiPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 94 IMGVISCFTLYMLAPHLAKLVIDGNDqtGNSVGAVTTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSALSVVVEQFFRV 173
Cdd:cd13123 83 LVLLLLTLLGILFAPLLVKLLAPGFS--GDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLVII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 174 LTILIGSFVVLYVLkasVSLAVGIsTFGAFMGAVGGLTVL--SAYYIRRRRHLKKKEMesipqttksffslyKELFTYSI 251
Cdd:cd13123 161 AGLLLLAPLFDLGI---YALAWGV-LLGGVLQLLVQLPALrrLGFRFRPRLDFRDPGV--------------RRVLKLML 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 252 PFVVVGLAIPLYQTIDTFTINKLliqigymqgeAEKINAIIGLVQMVVLIPVSV-ATAFSMSLVPEMTKAYTAGNTKLLY 330
Cdd:cd13123 223 PALLGVSVSQINLLVDTILASFL----------PEGSISALYYADRLYQLPLGIfGVAIATALLPRLSRLAAAGDLDEFR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 331 KHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGN----DPEMGRIILQYYAPACILFSLFTVTAAMLQGINQQQKTV 406
Cdd:cd13123 293 RTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGAftaeDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPV 372
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 446601499 407 LGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSK 453
Cdd:cd13123 373 KIAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
16-426 |
1.57e-12 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 68.89 E-value: 1.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 16 ATMISKMLGFIYVIPFTAMVGTSGYVLYTY--AYRPYTIMLSIATMGLPLAVSKMVSKYDQLNDYHTVKRVLKSGIVFMF 93
Cdd:cd12082 3 PLLLSMLLQTLYNLVDTFFLGRLLGDALAAvgLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 94 IMGVISCFTLYMLAPHLAKLVIDGNDQTGNSVGAVttniRIVSFALILVPVMSLLRGFFQGFQSMGPSALSVVVEQFfrv 173
Cdd:cd12082 83 LLGLLLAALLLFFSPLILSLLGAEEEVIELAATYL----TILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNL--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 174 ltILIGSFVVLYVLKASVSLAVGISTFGAFMGAVGGLtVLSAYYIRRRRHLKKKEMESIpqttKSFFSLYKELFTYSIPF 253
Cdd:cd12082 156 --LNILLDPLLIFGLGPPELGIAGAALATVISYVIGA-LLLLIYLRKGKKILKFKLSLL----KPDLELLRRLLRIGLPS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 254 VVVGLAIPLYQTIDTFTINKLLIQIGYmqgeaekinAIIGLVQMVVLIPVSVATAFSMSLVPEMTKAYTAGNTKLLYKHF 333
Cdd:cd12082 229 AIQNSLLSLGLLIIVAIVAAFGGAAAL---------AAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRIT 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 334 TRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNDPEMGRIILQYYAPACILFSLFTVTAAMLQGINQQQK-TVLGLVIG 412
Cdd:cd12082 300 WVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKsLIVSLLSY 379
|
410
....*....|....
gi 446601499 413 IIVKIVLNIVLLPY 426
Cdd:cd12082 380 WVVRLPLAYVLAYL 393
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
375-455 |
7.82e-11 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 59.89 E-value: 7.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 375 ILQYYAPACILFSLFTVTAAMLQGINQQQKTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSKY 454
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
.
gi 446601499 455 V 455
Cdd:pfam14667 81 L 81
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-450 |
2.97e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 58.62 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 1 MKGSPFIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLY---TYAYRPYTIMLSIAtMGLPLAVSKMVSKYDQLND 77
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALaavGLAFPIFFLLIALG-IGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 78 YHTVKRVLKSGIVFMFIMGVISCFTLYMLAPHLAKLVidgnDQTGNSVGAVTTNIRIVSFALILVPVMSLLRGFFQGFQS 157
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLL----GADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 158 MGPSALSVVVEqffrVLTILIGSFVVLYVLK---ASVSLAVGISTFGAFmgavggltVLSAYYIRRRRHLKKKEMESIpq 234
Cdd:COG0534 156 TKTPMIIMLIG----NVLNIVLDPLLIFGGGlgvAGAALATVISQAVSA--------LLLLYYLFRKRSLLRLRLRDL-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 235 ttKSFFSLYKELFTYSIPFVVVGLAIPLYQTIdtftINKLLIQIGymqgeaEKINAIIGLVQMVVLIPVSVATAFSMSLV 314
Cdd:COG0534 222 --RPDRKILKRILRIGLPAGLQQLAESLGFLV----LNALVARLG------TAAVAAYGIALRIESLAFMPALGLGQAAQ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 315 PEMTKAYTAGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLfgaGNDPE---MGRIILQYYAPACILFSLFTV 391
Cdd:COG0534 290 PLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLF---TDDPEviaLAATYLRIAALFQPFDGLQFV 366
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446601499 392 TAAMLQGInqqQKTVLGLVIGIIVKIVLNIVLL-----PYFDYVSFIISTYAGYTISVGFNLWM 450
Cdd:COG0534 367 LSGALRGA---GDTRFPMIISLLRLWLVRLPLAyllafLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
300-453 |
5.54e-09 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 58.07 E-value: 5.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 300 LIPVSVATAfsmsLVPEMTKAYTAGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGN----DPEMGRII 375
Cdd:pfam03023 248 IFGVSISTV----LLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNfspeDVTATAEV 323
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446601499 376 LQYYAPACILFSLFTVTAAMLQGINQQQKTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSK 453
Cdd:pfam03023 324 LAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYYILRK 401
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
51-434 |
1.45e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 56.70 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 51 TIMLSIAtMGLPLAVSKMVSKYDQLNDYHTVKRVLKSGIVFMFIMGVISCFTLYMLAPHLAKLVidgnDQTGNSVGAVTT 130
Cdd:cd13138 50 FLLTAIG-MGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLM----NTPAEILELAVS 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 131 NIRIVSFALILVPVMSLLRGFFQGF-QSMGPSALSVVVeqffrVLTILIGSFVVLYVLKASVSLAVgISTFGAFMGAVgg 209
Cdd:cd13138 125 YLRICFLGIPFIFGYNAYSAILRGLgDSKTPLYFVIIA-----CVLNIILDLLFIAVFHMGVAGAA-LATVIAQAISV-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 210 ltVLSAYYIRRRRH---LKKKEMesipqttKSFFSLYKELFTYSIPFVVVGLAIplyqTIDTFTINKLLIQIGYM----Q 282
Cdd:cd13138 197 --LLALYYLRKKKLpfkLSLKDF-------RFDKEILKEILKIGLPSALQQSLV----SISFLIINSIVNSYGVVasaaY 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 283 GEAEKINAIIGLVQMvvlipvsvatAFSMSLVPEMTKAYTAGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLL 362
Cdd:cd13138 264 GIANKINSFAFLPPS----------AIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLF 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446601499 363 FGAGNDPEMGRIILQYYAPACILFSLFTVTAAMLQGInqqQKTVLGLVIGII----VKIVLNIVLLPYFDYVSFII 434
Cdd:cd13138 334 TSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGL---GKTKFPMIISILrlwlVRIPLAYLLSRLTGLGLFGI 406
|
|
| MATE_epsE_like |
cd13129 |
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ... |
6-451 |
4.61e-07 |
|
Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240534 [Multi-domain] Cd Length: 411 Bit Score: 51.72 E-value: 4.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 6 FIRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYVLYTYAYRPYTIMLSIATMGLPLAVSKMVSKYdQLNDYHTVKRVL 85
Cdd:cd13129 2 FASGSFWSLGGLVASRGAVFLTNIMVARSLGKHVFGEFGVIQVTIGLLGTFAGFGLGLAATKVIAET-KDVDPERAGRII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 86 KSGIVFMFIMGVISCFTLYMLAPHLAKLVIdGNDQTGNSvgavttnIRIVSFALILVPVMSLLRGFFQGFQSMGPSAlSV 165
Cdd:cd13129 81 GLSILLAVVTGALAATVLFLSATWIAIATL-NAPHLAEL-------LRIAAIILILTAFTGAQTGFLSGFEAFRAIA-RV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 166 VVEQFFRVLTILIGSFVVLYVLKASVSlavgistfgaFMGAVGGLTVLSAYYIRRrrhlkKKEMESIPQTTKSFFSLYKE 245
Cdd:cd13129 152 NIWAGLLLLPLMWIGVYIRGLVGAVVI----------LLASAAGNVASNSLILRR-----ECQNQRGPVRTGLTWQELRV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 246 LFTYSIPFVVVGLAIPLYqtidTFTINKLLIQIGYMQGEAEKINAIIGLVQMVVLIPVSVAtafsMSLVPEMTKAYtaGN 325
Cdd:cd13129 217 LFKFSLPSVLSGSMGSPV----HWIALAILVNQPNGYAELGLFNAANQWRQFITFLPATLG----NVALPFLAENF--GN 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 326 TKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAgnDPEMGRIILQYYAPACILFSLFTVTAAMLQGINQQQKT 405
Cdd:cd13129 287 NEGMFRQTFRSALLFGLGLSLPLGCVFILASQIFAWLYGK--EYGSAAASMRSLAVAAILVGLSVLLGQIIASSGKIWRG 364
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 446601499 406 VLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWML 451
Cdd:cd13129 365 FALNMVWSVIYVAAAYLLLRLYGAPGLALAMSAAYCVLIIFQTLTL 410
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
7-453 |
2.96e-05 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 46.16 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 7 IRGTIFLTMATMISKMLGFIYVIPFTAMVGTSGYV-LYTYAYRPYTIMLSIATMGlpLAVSKMVSKYDQLNDYHTVKRVL 85
Cdd:TIGR01695 3 LKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTAdAFNVAFVIPNFFRRLFAEG--AFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 86 KSGIVFMFIMGVISCFTLYML--APHLAKLVIDGNDQTGNSVGAvtTNIRIVSFALILVPVMSLLRGFFQGFQSMGPSAL 163
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIffAPFVISLLAPGFADETRSLAV--SLTRIMFPYLLLISLAAVFGGILNARKRFFIPSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 164 SVVveqFFRVLTILIGSFVVLYVLKASVSLAVGIsTFGAFMGAVGGLTvlsayyirrrrHLKKKEMESIPQTTKSFFSLy 243
Cdd:TIGR01695 159 SPI---LFNIGVILSLLFFDWNYGQYSLALAIGV-LIGGVAQLLIQLP-----------FLRKAGFLLKPRFNFRDPGL- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 244 KELFTYSIPFVVVGLAIPLYQTIDTFTINKLLI-QIGYMQGEaekiNAIIGLVQMVVLIPVSVAtafsmsLVPEMTKAYT 322
Cdd:TIGR01695 223 KRFLKLFLPTTLGSSASQITLLINTALASFLEIgSVSALYYA----NRIYQLPLGIFGISLSTV------LLPKLSRHAS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 323 AGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGN----DPEMGRIILQYYAPACILFSLFTVTAAMLQG 398
Cdd:TIGR01695 293 EGNWNELRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGAfseeDTVMTATILAAYGLGLIFYSLQKVLLRAFYA 372
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 446601499 399 INQQQKTVLGLVIGIIVKIVLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSK 453
Cdd:TIGR01695 373 RKDTRTPFINSVISVVLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNR 427
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
252-423 |
1.75e-03 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 39.09 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 252 PFVVVGLAIPLYQTIDTFTINKLliqigymqgeAEKINAIIGLVQMVVLIPVSVATAFSMSLVPEMTKAYTAGNTKLLYK 331
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL----------GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 332 HFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNDPEMGRIILQYYAPACILFSLFTVTAAMLQGinqQQKTVLGLVI 411
Cdd:pfam01554 71 ALRQGLILGLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRG---QGDTKPPMYI 147
|
170
....*....|..
gi 446601499 412 GIIVkIVLNIVL 423
Cdd:pfam01554 148 NIIS-LLLNIPL 158
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
244-455 |
2.56e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 40.16 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 244 KELFTYSIPFVVVGLAIPLYQTIDTFTINKLL--IQIG-YMQGEaekinaiiglvQMVVLIPVSVATAFSMSLVPEMTKA 320
Cdd:cd13127 199 KELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLgaAALGyYSRAY-----------RLALLPVQNITGPITRVLFPALSRL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 321 ytAGNTKLLYKHFTRTNVLVVAITVPAAIGMMVLAKPVYTLLFGAGNDPEMgrIILQYYAPACILFSLFTVTAAMLQGIN 400
Cdd:cd13127 268 --QDDPERLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGEKWLPAV--PILQILALAGLFQPLSSLNGSLLLALG 343
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446601499 401 qqqKTVLGLVIGIIVKI--VLNIVLLPYFDYVSFIISTYAGYTISVGFNLWMLSKYV 455
Cdd:cd13127 344 ---RTDLLLKLGLIKAVltVLALLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLI 397
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
59-223 |
6.83e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 38.59 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 59 MGLPLAVSKMVSKYDQLNDYHTVKRVLKSGIVFMFIMGVISCFTLYMLAPHLAKLVIdgNDQtgNSVGAVTTNIRIVSFA 138
Cdd:cd13138 278 SAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFT--SDP--EVIEIGAEYLRIYSID 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446601499 139 LILVPVMSLLRGFFQGF-QSMGPSALSVVVEQFFRVLTILIGSFVVLYVLKaSVSLAVGISTFGAFMgavggltVLSAYY 217
Cdd:cd13138 354 YILFGILFVFNGLFRGLgKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLF-GIWLAMPISNILSAI-------ICIIYY 425
|
....*.
gi 446601499 218 IRRRRH 223
Cdd:cd13138 426 RKGRWK 431
|
|
| |
