tagatose-bisphosphate aldolase subunit KbaZ is a component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit
D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Aldolases specific for ...
5-424
0e+00
D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Aldolases specific for D-tagatose-bisphosphate occur in distinct pathways in Escherichia coli and other bacteria, one for the degradation of galactitol (formerly dulcitol) and one for degradation of N-acetyl-galactosamine and D-galactosamine. This family represents a protein of both systems that behaves as a non-catalytic subunit of D-tagatose-bisphosphate aldolase, required both for full activity and for good stability of the aldolase. Note that members of this protein family appear in public databases annotated as putative tagatose 6-phosphate kinases, possibly in error. [Energy metabolism, Sugars]
Pssm-ID: 274309 Cd Length: 420 Bit Score: 791.56 E-value: 0e+00
D-tagatose-1,6-bisphosphate aldolase subunit GatZ/KbaZ-like; Escherichia coli and other ...
4-423
0e+00
D-tagatose-1,6-bisphosphate aldolase subunit GatZ/KbaZ-like; Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases involved in catabolism of galactitol (genes gatY gatZ) and of N-acetyl-galactosamine and D-galactosamine (genes kbaY, kbaZ, also called agaY, agaZ). The catalytic subunits GatY/KbaY alone are sufficient to show aldolase activity and contain most or all of the residues that have been identified as essential in substrate/product recognition and catalysis for class II aldolases. However, these aldolases differ from other Class II aldolases (which are homodimeric enzymes) in that they require subunits GatZ/KbaZ for full activity and for good in vivo and in vitro stability. The Z subunits alone do not show any aldolase activity. This entry represents GatZ and KbaZ subunits. This entry also includes the D-tagatose 6-phosphate 4-epimerase Atu3167 from Agrobacterium fabrum which catalyzes the epimerization of D-tagatose 6-phosphate to D-fructose 6-phosphate. It should be noted that the previous suggestion of a tagatose 6P-kinase function for other members of this family has been debated.
Pssm-ID: 429785 Cd Length: 420 Bit Score: 782.49 E-value: 0e+00
D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Aldolases specific for ...
5-424
0e+00
D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Aldolases specific for D-tagatose-bisphosphate occur in distinct pathways in Escherichia coli and other bacteria, one for the degradation of galactitol (formerly dulcitol) and one for degradation of N-acetyl-galactosamine and D-galactosamine. This family represents a protein of both systems that behaves as a non-catalytic subunit of D-tagatose-bisphosphate aldolase, required both for full activity and for good stability of the aldolase. Note that members of this protein family appear in public databases annotated as putative tagatose 6-phosphate kinases, possibly in error. [Energy metabolism, Sugars]
Pssm-ID: 274309 Cd Length: 420 Bit Score: 791.56 E-value: 0e+00
D-tagatose-1,6-bisphosphate aldolase subunit GatZ/KbaZ-like; Escherichia coli and other ...
4-423
0e+00
D-tagatose-1,6-bisphosphate aldolase subunit GatZ/KbaZ-like; Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases involved in catabolism of galactitol (genes gatY gatZ) and of N-acetyl-galactosamine and D-galactosamine (genes kbaY, kbaZ, also called agaY, agaZ). The catalytic subunits GatY/KbaY alone are sufficient to show aldolase activity and contain most or all of the residues that have been identified as essential in substrate/product recognition and catalysis for class II aldolases. However, these aldolases differ from other Class II aldolases (which are homodimeric enzymes) in that they require subunits GatZ/KbaZ for full activity and for good in vivo and in vitro stability. The Z subunits alone do not show any aldolase activity. This entry represents GatZ and KbaZ subunits. This entry also includes the D-tagatose 6-phosphate 4-epimerase Atu3167 from Agrobacterium fabrum which catalyzes the epimerization of D-tagatose 6-phosphate to D-fructose 6-phosphate. It should be noted that the previous suggestion of a tagatose 6P-kinase function for other members of this family has been debated.
Pssm-ID: 429785 Cd Length: 420 Bit Score: 782.49 E-value: 0e+00
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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