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Conserved domains on  [gi|446604727|ref|WP_000682073|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Bacillus]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11441299)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to sulfide:quinone oxidoreductase which catalyzes the oxidation of hydrogen sulfide using quinone as the electron acceptor

EC:  1.6.-.-
Gene Ontology:  GO:0003954|GO:0006116
PubMed:  15590775|28181562

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
1-355 6.39e-102

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


:

Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 305.52  E-value: 6.39e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   1 MKHLVILGGGYGGMRILQRLlpSNQLPDDVQVTLIDKVPYHCFKTEYYALVAGTISETHIRIPFPEH-PRLNIQY--GTV 77
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRL--RKKLGGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELlRRAGVRFiqGEV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  78 TNIDLEEKAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGAKEYTHSLQSIEQTRKTYEQLNSLEPNA------TVAVVGAG 151
Cdd:COG1252   79 TGIDPEARTVTLADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAerrrllTIVVVGGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 152 LSGVEVASELRE-----------SRSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-IVYNH 219
Cdd:COG1252  159 PTGVELAGELAEllrkllrypgiDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADgVTLED 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 220 DEPLECDAIVWTAGIQANEVVRNLPVEQDGSGRVVLTKYHNIPNNEHVYVVGDCAAL------PHAPSAQLAEGQGEQIV 293
Cdd:COG1252  239 GEEIPADTVIWAAGVKAPPLLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVpdpdgkPVPKTAQAAVQQAKVLA 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446604727 294 QILLKRWHNEPLPDELPviKLKGVLGSLGKKHGFGLLANQPLMGRVPRLLKSGI--LWMYKYHN 355
Cdd:COG1252  319 KNIAALLRGKPLKPFRY--RDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIhlYFLPGFRG 380
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
1-355 6.39e-102

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 305.52  E-value: 6.39e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   1 MKHLVILGGGYGGMRILQRLlpSNQLPDDVQVTLIDKVPYHCFKTEYYALVAGTISETHIRIPFPEH-PRLNIQY--GTV 77
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRL--RKKLGGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELlRRAGVRFiqGEV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  78 TNIDLEEKAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGAKEYTHSLQSIEQTRKTYEQLNSLEPNA------TVAVVGAG 151
Cdd:COG1252   79 TGIDPEARTVTLADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAerrrllTIVVVGGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 152 LSGVEVASELRE-----------SRSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-IVYNH 219
Cdd:COG1252  159 PTGVELAGELAEllrkllrypgiDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADgVTLED 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 220 DEPLECDAIVWTAGIQANEVVRNLPVEQDGSGRVVLTKYHNIPNNEHVYVVGDCAAL------PHAPSAQLAEGQGEQIV 293
Cdd:COG1252  239 GEEIPADTVIWAAGVKAPPLLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVpdpdgkPVPKTAQAAVQQAKVLA 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446604727 294 QILLKRWHNEPLPDELPviKLKGVLGSLGKKHGFGLLANQPLMGRVPRLLKSGI--LWMYKYHN 355
Cdd:COG1252  319 KNIAALLRGKPLKPFRY--RDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIhlYFLPGFRG 380
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-289 1.13e-33

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 126.28  E-value: 1.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727    2 KHLVILGGGYGGMRILQRLLPSNqlpddVQVTLIDK---VPYH-CFKTEYYALVAGTISETHIRIPFPEHPR-------L 70
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLG-----GKVTLIEDegtCPYGgCVLSKALLGAAEAPEIASLWADLYKRKEevvkklnN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   71 NIQY---GTVTNIDLEEKAVHL-----DGGEAIQYDDLIIGLGCEDKYHNVPGAKE-YTHSLQSIEQTrktyEQLNSLEP 141
Cdd:pfam07992  76 GIEVllgTEVVSIDPGAKKVVLeelvdGDGETITYDRLVIATGARPRLPPIPGVELnVGFLVRTLDSA----EALRLKLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  142 NATVAVVGAGLSGVEVASELRESRSdlKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN---IVYN 218
Cdd:pfam07992 152 PKRVVVVGGGYIGVELAAALAKLGK--EVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDgdgVEVI 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446604727  219 HDEP--LECDAIVWTAGIQAN-EVVRNLPVEQDGSGRVVLTKYHNIpNNEHVYVVGDCAAlPHAPSAQLAEGQG 289
Cdd:pfam07992 230 LKDGteIDADLVVVAIGRRPNtELLEAAGLELDERGGIVVDEYLRT-SVPGIYAAGDCRV-GGPELAQNAVAQG 301
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 4-353 8.64e-30

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 118.33  E-value: 8.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   4 LVILGGGYGGMRILQRLLPSNQlpdDVQVTlidKVPYHCFKTeyyALVAGTISET--HIRIPFPEHPRLNIQ-----YGT 76
Cdd:PTZ00318  13 VVVLGTGWAGAYFVRNLDPKKY---NITVI---SPRNHMLFT---PLLPQTTTGTleFRSICEPVRPALAKLpnrylRAV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  77 VTNIDLEEKAV----------HLDGGEAIQYDDLIIGLGCEDKYHNVPGAKEYTHSLQSIEQTRKTYEQL---------- 136
Cdd:PTZ00318  84 VYDVDFEEKRVkcgvvsksnnANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIvqcieraslp 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 137 -NSLEPNA---TVAVVGAGLSGVEVASELRESRSDL------------KIYLFDRKDRILFPYPEKLSRYVEEWFVKHKV 200
Cdd:PTZ00318 164 tTSVEERKrllHFVVVGGGPTGVEFAAELADFFRDDvrnlnpelveecKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 201 TIIRNSNITKV-EPNIVYNHDEPLECDAIVWTAGIQANEVVRNLPVEQDGSGRVVLTKYHNIPNNEHVYVVGDCAAL--- 276
Cdd:PTZ00318 244 DIRTKTAVKEVlDKEVVLKDGEVIPTGLVVWSTGVGPGPLTKQLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANeer 323

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446604727 277 PHAPSAQLAEGQGEQIVQILLKRWHNEPLPDELpVIKLKGVLGSLGKKHGFGLLANQPLMGrvprlLKSGILWMYKY 353
Cdd:PTZ00318 324 PLPTLAQVASQQGVYLAKEFNNELKGKPMSKPF-VYRSLGSLAYLGNYSAIVQLGAFDLSG-----FKALLFWRSAY 394
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 100-274 2.01e-03

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 39.84  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  100 LIIGLGCEDKYHNVPGAKEYthslqSIeqtrkTYEQLNSLE--PNATVaVVGAGLSGVEVASELRESRSDLKIYLfdrKD 177
Cdd:TIGR01438 147 FLIATGERPRYPGIPGAKEL-----CI-----TSDDLFSLPycPGKTL-VVGASYVALECAGFLAGIGLDVTVMV---RS 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  178 RILFPYPEKLSRYVEEWFVKHKVTIIRN---SNITKVEPNIVY---NHDEPL--ECDAIVWTAGIQANevVRNLPVEQDG 249
Cdd:TIGR01438 213 ILLRGFDQDCANKVGEHMEEHGVKFKRQfvpIKVEQIEAKVLVeftDSTNGIeeEYDTVLLAIGRDAC--TRKLNLENVG 290

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446604727  250 ------SGRVVLTKYH--NIPnneHVYVVGDCA 274
Cdd:TIGR01438 291 vkinkkTGKIPADEEEqtNVP---YIYAVGDIL 320
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
1-355 6.39e-102

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 305.52  E-value: 6.39e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   1 MKHLVILGGGYGGMRILQRLlpSNQLPDDVQVTLIDKVPYHCFKTEYYALVAGTISETHIRIPFPEH-PRLNIQY--GTV 77
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRL--RKKLGGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELlRRAGVRFiqGEV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  78 TNIDLEEKAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGAKEYTHSLQSIEQTRKTYEQLNSLEPNA------TVAVVGAG 151
Cdd:COG1252   79 TGIDPEARTVTLADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAerrrllTIVVVGGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 152 LSGVEVASELRE-----------SRSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-IVYNH 219
Cdd:COG1252  159 PTGVELAGELAEllrkllrypgiDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADgVTLED 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 220 DEPLECDAIVWTAGIQANEVVRNLPVEQDGSGRVVLTKYHNIPNNEHVYVVGDCAAL------PHAPSAQLAEGQGEQIV 293
Cdd:COG1252  239 GEEIPADTVIWAAGVKAPPLLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVpdpdgkPVPKTAQAAVQQAKVLA 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446604727 294 QILLKRWHNEPLPDELPviKLKGVLGSLGKKHGFGLLANQPLMGRVPRLLKSGI--LWMYKYHN 355
Cdd:COG1252  319 KNIAALLRGKPLKPFRY--RDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIhlYFLPGFRG 380
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 28-299 3.83e-43

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 151.89  E-value: 3.83e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  28 DDVQVTLIDKVPYHcfkteYYA------LVAGTI---SETHIRIP-FPEHPRLNIQYGT-VTNIDLEEKAVHLDGGEAIQ 96
Cdd:COG0446    4 PDAEITVIEKGPHH-----SYQpcglpyYVGGGIkdpEDLLVRTPeSFERKGIDVRTGTeVTAIDPEAKTVTLRDGETLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  97 YDDLIIGLGCEDKYHNVPGAK-EYTHSLQSIEQTRKTYEQLNSLEPNaTVAVVGAGLSGVEVASELResRSDLKIYLFDR 175
Cdd:COG0446   79 YDKLVLATGARPRPPPIPGLDlPGVFTLRTLDDADALREALKEFKGK-RAVVIGGGPIGLELAEALR--KRGLKVTLVER 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 176 KDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN----IVYNHDEPLECDAIVWTAGIQAN-EVVRNLPVEQDGS 250
Cdd:COG0446  156 APRLLGVLDPEMAALLEEELREHGVELRLGETVVAIDGDdkvaVTLTDGEEIPADLVVVAPGVRPNtELAKDAGLALGER 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446604727 251 GRVVLTKY--HNIPNnehVYVVGDCAALPHA--------PSAQLAEGQGEQIVQILLKR 299
Cdd:COG0446  236 GWIKVDETlqTSDPD---VYAAGDCAEVPHPvtgktvyiPLASAANKQGRVAAENILGG 291
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-289 1.13e-33

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 126.28  E-value: 1.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727    2 KHLVILGGGYGGMRILQRLLPSNqlpddVQVTLIDK---VPYH-CFKTEYYALVAGTISETHIRIPFPEHPR-------L 70
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLG-----GKVTLIEDegtCPYGgCVLSKALLGAAEAPEIASLWADLYKRKEevvkklnN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   71 NIQY---GTVTNIDLEEKAVHL-----DGGEAIQYDDLIIGLGCEDKYHNVPGAKE-YTHSLQSIEQTrktyEQLNSLEP 141
Cdd:pfam07992  76 GIEVllgTEVVSIDPGAKKVVLeelvdGDGETITYDRLVIATGARPRLPPIPGVELnVGFLVRTLDSA----EALRLKLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  142 NATVAVVGAGLSGVEVASELRESRSdlKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN---IVYN 218
Cdd:pfam07992 152 PKRVVVVGGGYIGVELAAALAKLGK--EVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDgdgVEVI 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446604727  219 HDEP--LECDAIVWTAGIQAN-EVVRNLPVEQDGSGRVVLTKYHNIpNNEHVYVVGDCAAlPHAPSAQLAEGQG 289
Cdd:pfam07992 230 LKDGteIDADLVVVAIGRRPNtELLEAAGLELDERGGIVVDEYLRT-SVPGIYAAGDCRV-GGPELAQNAVAQG 301
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 4-353 8.64e-30

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 118.33  E-value: 8.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   4 LVILGGGYGGMRILQRLLPSNQlpdDVQVTlidKVPYHCFKTeyyALVAGTISET--HIRIPFPEHPRLNIQ-----YGT 76
Cdd:PTZ00318  13 VVVLGTGWAGAYFVRNLDPKKY---NITVI---SPRNHMLFT---PLLPQTTTGTleFRSICEPVRPALAKLpnrylRAV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  77 VTNIDLEEKAV----------HLDGGEAIQYDDLIIGLGCEDKYHNVPGAKEYTHSLQSIEQTRKTYEQL---------- 136
Cdd:PTZ00318  84 VYDVDFEEKRVkcgvvsksnnANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIvqcieraslp 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 137 -NSLEPNA---TVAVVGAGLSGVEVASELRESRSDL------------KIYLFDRKDRILFPYPEKLSRYVEEWFVKHKV 200
Cdd:PTZ00318 164 tTSVEERKrllHFVVVGGGPTGVEFAAELADFFRDDvrnlnpelveecKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 201 TIIRNSNITKV-EPNIVYNHDEPLECDAIVWTAGIQANEVVRNLPVEQDGSGRVVLTKYHNIPNNEHVYVVGDCAAL--- 276
Cdd:PTZ00318 244 DIRTKTAVKEVlDKEVVLKDGEVIPTGLVVWSTGVGPGPLTKQLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANeer 323

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446604727 277 PHAPSAQLAEGQGEQIVQILLKRWHNEPLPDELpVIKLKGVLGSLGKKHGFGLLANQPLMGrvprlLKSGILWMYKY 353
Cdd:PTZ00318 324 PLPTLAQVASQQGVYLAKEFNNELKGKPMSKPF-VYRSLGSLAYLGNYSAIVQLGAFDLSG-----FKALLFWRSAY 394
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
1-326 1.78e-29

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 116.78  E-value: 1.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   1 MKHLVILGGGYGGMRILQRLLpsnQLPDDVQVTLIDKVPYHCfkteYY-----ALVAGTISETHIRIP---FPEHPRLNI 72
Cdd:COG1251    1 KMRIVIIGAGMAGVRAAEELR---KLDPDGEITVIGAEPHPP----YNrpplsKVLAGETDEEDLLLRpadFYEENGIDL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  73 QYGT-VTNIDLEEKAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGA-KEYTHSLQSIEQTRKTYEQLnslEPNATVAVVGA 150
Cdd:COG1251   74 RLGTrVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPIPGAdLPGVFTLRTLDDADALRAAL---APGKRVVVIGG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 151 GLSGVEVASELREsrSDLKIYLFDRKDRILfPY--PEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-----IVYNHDEPL 223
Cdd:COG1251  151 GLIGLEAAAALRK--RGLEVTVVERAPRLL-PRqlDEEAGALLQRLLEALGVEVRLGTGVTEIEGDdrvtgVRLADGEEL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 224 ECDAIVWTAGIQAN-EVVRN--LPVEQ----DGSGRVvltkyhnipNNEHVYVVGDCAALPHA-------PSAQLAEGQG 289
Cdd:COG1251  228 PADLVVVAIGVRPNtELARAagLAVDRgivvDDYLRT---------SDPDIYAAGDCAEHPGPvygrrvlELVAPAYEQA 298

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 446604727 290 EQIVQILLKRwhNEPLPDELPVIKLK--GV-LGSLGKKHG 326
Cdd:COG1251  299 RVAAANLAGG--PAAYEGSVPSTKLKvfGVdVASAGDAEG 336
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
72-274 1.61e-11

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 64.37  E-value: 1.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  72 IQYGTVTNIDLEE--KAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGAKEYTH---SLQSIEQTRKTyeqlnslePNATVA 146
Cdd:COG0492   74 ILLEEVTSVDKDDgpFRVTTDDGTEYEAKAVIIATGAGPRKLGLPGEEEFEGrgvSYCATCDGFFF--------RGKDVV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 147 VVGAGLSGVEVASEL-RESRsdlKIYLFDRKDRIlfpypeKLSRY-VEEWFVKHKVTIIRNSNITKVEPN------IVYN 218
Cdd:COG0492  146 VVGGGDSALEEALYLtKFAS---KVTLIHRRDEL------RASKIlVERLRANPKIEVLWNTEVTEIEGDgrvegvTLKN 216

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446604727 219 HD----EPLECDAIVWTAGIQAN-EVVRNLPVEQDGSGRVVlTKYH---NIPNnehVYVVGDCA 274
Cdd:COG0492  217 VKtgeeKELEVDGVFVAIGLKPNtELLKGLGLELDEDGYIV-VDEDmetSVPG---VFAAGDVR 276
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 145-283 2.93e-11

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 64.34  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 145 VAVVGAGLSGVEVASELResRSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-----IVYNH 219
Cdd:COG1249  171 LVVIGGGYIGLEFAQIFA--RLGSEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTSVEKTgdgvtVTLED 248

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446604727 220 D---EPLECDAIVWTAGIQANevVRNLPVEQ-----DGSGRVVLTKYHNIpNNEHVYVVGDCA---ALPHAPSAQ 283
Cdd:COG1249  249 GggeEAVEADKVLVATGRRPN--TDGLGLEAagvelDERGGIKVDEYLRT-SVPGIYAIGDVTggpQLAHVASAE 320
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 145-214 3.90e-11

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 58.37  E-value: 3.90e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  145 VAVVGAGLSGVEVASELRESRSdlKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN 214
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARLGS--KVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIEGN 69
PRK06116 PRK06116
glutathione reductase; Validated
 91-273 1.37e-10

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 62.10  E-value: 1.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  91 GGEAIQYDDLIIGLGCEDKYHNVPGAkEYTHSLQSI----EQTRKtyeqlnslepnatVAVVGAGLSGVEVASELRESRS 166
Cdd:PRK06116 126 NGERYTADHILIATGGRPSIPDIPGA-EYGITSDGFfaleELPKR-------------VAVVGAGYIAVEFAGVLNGLGS 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 167 DlkIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN------IVYNHDEPLECDAIVWTAGIQANEVV 240
Cdd:PRK06116 192 E--THLFVRGDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVPKAVEKNadgsltLTLEDGETLTVDCLIWAIGREPNTDG 269

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446604727 241 RNL---PVEQDGSGRVVLTKYHNIpNNEHVYVVGDC 273
Cdd:PRK06116 270 LGLenaGVKLNEKGYIIVDEYQNT-NVPGIYAVGDV 304
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
2-184 8.70e-09

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 56.50  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   2 KHLVILGGGYGGMRILQRLLpsNQLPDDVQVTLIDK-------VPYHcfKTEYYALV---AGTIS--------------E 57
Cdd:COG4529    6 KRIAIIGGGASGTALAIHLL--RRAPEPLRITLFEPrpelgrgVAYS--TDSPEHLLnvpAGRMSafpddpdhflrwlrE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  58 THIRIPFPEHP----------------------------RLNIQYGTVTNIDLEEK--AVHLDGGEAIQYDDLIIGLGce 107
Cdd:COG4529   82 NGARAAPAIDPdafvprrlfgeylrerlaealarapagvRLRHIRAEVVDLERDDGgyRVTLADGETLRADAVVLATG-- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 108 dkyHNVPGAkeythsLQSIEQTRKTY-------EQLNSLEPNATVAVVGAGLSGVEVASELRESRSDLKIYLFDRkdRIL 180
Cdd:COG4529  160 ---HPPPAP------PPGLAAGSPRYiadpwppGALARIPPDARVLIIGTGLTAIDVVLSLAARGHRGPITALSR--RGL 228


                 ....
gi 446604727 181 FPYP 184
Cdd:COG4529  229 LPRA 232
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
77-274 1.75e-08

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 55.31  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  77 VTNIDLEEKAVHLDGgEAIQYDDLIIGLGCEDKYHNVPGaKEYTHSLQSIEQTRKTYEQLNSLEpnaTVAVVGAGLSGVE 156
Cdd:PRK04965  81 VTDIDAEAQVVKSQG-NQWQYDKLVLATGASAFVPPIPG-RELMLTLNSQQEYRAAETQLRDAQ---RVLVVGGGLIGTE 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 157 VASELreSRSDLKIYLFDRKDRILFPY-PEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-----IVYNHDEPLECDAIVW 230
Cdd:PRK04965 156 LAMDL--CRAGKAVTLVDNAASLLASLmPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTdsgirATLDSGRSIEVDAVIA 233

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446604727 231 TAGIQANEVV---RNLPVEQDgsgrVVLTKYHNIPNNeHVYVVGDCA 274
Cdd:PRK04965 234 AAGLRPNTALarrAGLAVNRG----IVVDSYLQTSAP-DIYALGDCA 275
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 77-278 2.21e-08

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 55.43  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  77 VTNIDLEEKAV---HLDGGEAIQ--YDDLIIGLGCEDKYHNVPGAK-EYTHSLQSIEQTRKTYEQLNSlEPNATVAVVGA 150
Cdd:PRK09564  79 VVKVDAKNKTItvkNLKTGSIFNdtYDKLMIATGARPIIPPIKNINlENVYTLKSMEDGLALKELLKD-EEIKNIVIIGA 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 151 GLSGVEVASELRESRSDLKIylFDRKDRIL-FPYPEKLSRYVEEWFVKHKV---------TIIRNSNITKVepniVYNHD 220
Cdd:PRK09564 158 GFIGLEAVEAAKHLGKNVRI--IQLEDRILpDSFDKEITDVMEEELRENGVelhlnefvkSLIGEDKVEGV----VTDKG 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446604727 221 EpLECDAIVWTAGIQAN-EVVRNLPVEQDGSGRVVLTKYHNIpNNEHVYVVGDCAALPH 278
Cdd:PRK09564 232 E-YEADVVIVATGVKPNtEFLEDTGLKTLKNGAIIVDEYGET-SIENIYAAGDCATIYN 288
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 77-326 1.83e-06

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 49.73  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  77 VTNIDLEEKAVHLDGGEAIQYDDLIIGLGcedKYHNVPGAKEYTHSLQSIeqtRKTYEQLNSLEPNA----TVAVVGAGL 152
Cdd:PRK14989  82 AITINRQEKVIHSSAGRTVFYDKLIMATG---SYPWIPPIKGSETQDCFV---YRTIEDLNAIEACArrskRGAVVGGGL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 153 SGVEVASELRESRSDLKIYLF------DRKDRIlfpYPEKLSRYVEEWFVK-H--KVTIIRNSNITKVEPNIVYNHDEPL 223
Cdd:PRK14989 156 LGLEAAGALKNLGVETHVIEFapmlmaEQLDQM---GGEQLRRKIESMGVRvHtsKNTLEIVQEGVEARKTMRFADGSEL 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 224 ECDAIVWTAGIQANEVVRN---LPVEQDGSgrvVLTKYHNIPNNEHVYVVGDCAALPHAPSAQLAEG--QGEQIVQILLK 298
Cdd:PRK14989 233 EVDFIVFSTGIRPQDKLATqcgLAVAPRGG---IVINDSCQTSDPDIYAIGECASWNNRVFGLVAPGykMAQVAVDHLLG 309

                        250       260
                 ....*....|....*....|....*....
gi 446604727 299 RWHNEPLPDELPVIKLKGV-LGSLGKKHG 326
Cdd:PRK14989 310 SENAFEGADLSAKLKLLGVdVGGIGDAHG 338
PTZ00058 PTZ00058
glutathione reductase; Provisional
 83-273 4.06e-06

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 48.46  E-value: 4.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  83 EEKAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGaKEYTHSLQSIEQtrktyeqlnsLEPNATVAVVGAGLSGVEVASELR 162
Cdd:PTZ00058 189 SAGVSQLDDGQVIEGKNILIAVGNKPIFPDVKG-KEFTISSDDFFK----------IKEAKRIGIAGSGYIAVELINVVN 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 163 esRSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPN-------IVYNHDEPLECDAIVWTAGIQ 235
Cdd:PTZ00058 258 --RLGAESYIFARGNRLLRKFDETIINELENDMKKNNINIITHANVEEIEKVkeknltiYLSDGRKYEHFDYVIYCVGRS 335

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446604727 236 ANEVVRNLPVEQDGS--GRVVLTKYHNIpNNEHVYVVGDC 273
Cdd:PTZ00058 336 PNTEDLNLKALNIKTpkGYIKVDDNQRT-SVKHIYAVGDC 374
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
46-271 1.35e-05

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 46.06  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727   46 EYYALVAgtisethiripfpEHPRLNIQYGT-VTNIDLEEKA--VHLDGGEaIQYDDLIIGLGcEDKYHNVPGAKEYths 122
Cdd:pfam13738  79 EYLRRVA-------------DHFELPINLFEeVTSVKKEDDGfvVTTSKGT-YQARYVIIATG-EFDFPNKLGVPEL--- 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  123 lqsieqtRKTYEQLNSLEPNAT--VAVVGAGLSGVEVASELreSRSDLKIYLFDRKDRILFPYPEK---LSRYVEEWF-- 195
Cdd:pfam13738 141 -------PKHYSYVKDFHPYAGqkVVVIGGYNSAVDAALEL--VRKGARVTVLYRGSEWEDRDSDPsysLSPDTLNRLee 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  196 -VKH-KVTIIRNSNITKVE--PNIVYNHDE-----PLECDAIVWTaGIQAN-EVVRNLPVEQDGSGRVVLTKYH---NIP 262
Cdd:pfam13738 212 lVKNgKIKAHFNAEVKEITevDVSYKVHTEdgrkvTSNDDPILAT-GYHPDlSFLKKGLFELDEDGRPVLTEETestNVP 290


                  ....*....
gi 446604727  263 NnehVYVVG 271
Cdd:pfam13738 291 G---LFLAG 296
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 56-238 3.24e-05

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 45.30  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  56 SETHIRIPFPEH----PRLNIQYG-TVTNIDLEEKAVHLDGGEAIQYDDLIIGLGCEDKYHNVPGA-KEYTHSLQSIEQT 129
Cdd:PRK09754  55 DSPQLQQVLPANwwqeNNVHLHSGvTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDAlGERCFTLRHAGDA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 130 RKTYEqlnSLEPNATVAVVGAGLSGVEVASELRESRSdlKIYLFDRKDRILFP-YPEKLSRYVEEWFVKHKVTIIRNSNI 208
Cdd:PRK09754 135 ARLRE---VLQPERSVVIVGAGTIGLELAASATQRRC--KVTVIELAATVMGRnAPPPVQRYLLQRHQQAGVRILLNNAI 209

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446604727 209 TKV----EPNIVYNHDEPLECDAIVWTAGIQANE 238
Cdd:PRK09754 210 EHVvdgeKVELTLQSGETLQADVVIYGIGISAND 243
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 145-277 7.20e-05

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 44.40  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 145 VAVVGAGLSGVEVASELreSRSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVK-------HKVTIIRNSNITKVEPNIVY 217
Cdd:PRK06292 172 LAVIGGGVIGLELGQAL--SRLGVKVTVFERGDRILPLEDPEVSKQAQKILSKefkiklgAKVTSVEKSGDEKVEELEKG 249

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446604727 218 NHDEPLECDAIVWTAGIQAN---EVVRNLPVEQDGSGRVVlTKYHNIPNNEHVYVVGDCAALP 277
Cdd:PRK06292 250 GKTETIEADYVLVATGRRPNtdgLGLENTGIELDERGRPV-VDEHTQTSVPGIYAAGDVNGKP 311
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 69-296 1.65e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 40.23  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  69 RLNIQYGT-VTNIDLEEKA----VHLDGGEAIQYDDLIIGLGCED--KYHNVPGAKEYT----HSlqsieQTRKTYEQLn 137
Cdd:COG2072   96 RRPIRFGTeVTSARWDEADgrwtVTTDDGETLTARFVVVATGPLSrpKIPDIPGLEDFAgeqlHS-----ADWRNPVDL- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 138 slePNATVAVVGAGLSGVEVASELRESRSDLkiYLFDR------------------KDRILFPYPEKLSRY-VEEWFVKH 198
Cdd:COG2072  170 ---AGKRVLVVGTGASAVQIAPELARVAAHV--TVFQRtppwvlprpnydpergrpANYLGLEAPPALNRRdARAWLRRL 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 199 -------------------------------------KVTiIRNSNITKVEPN-IVYNHDEPLECDAIVWTAGIQANEvv 240
Cdd:COG2072  245 lraqvkdpelglltpdyppgckrpllstdyyealrrgNVE-LVTGGIERITEDgVVFADGTEHEVDVIVWATGFRADL-- 321

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446604727 241 RNLPVEQ--DGSGRVVLTKYH-----NIPNnehVYVVGDCAALPHAPSAQLAEGQGEQIVQIL 296
Cdd:COG2072  322 PWLAPLDvrGRDGRSGPRAYLgvvvpGFPN---LFFLGPNSPSGHSSLTLGAERQARYIARLI 381
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 100-274 2.01e-03

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 39.84  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  100 LIIGLGCEDKYHNVPGAKEYthslqSIeqtrkTYEQLNSLE--PNATVaVVGAGLSGVEVASELRESRSDLKIYLfdrKD 177
Cdd:TIGR01438 147 FLIATGERPRYPGIPGAKEL-----CI-----TSDDLFSLPycPGKTL-VVGASYVALECAGFLAGIGLDVTVMV---RS 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  178 RILFPYPEKLSRYVEEWFVKHKVTIIRN---SNITKVEPNIVY---NHDEPL--ECDAIVWTAGIQANevVRNLPVEQDG 249
Cdd:TIGR01438 213 ILLRGFDQDCANKVGEHMEEHGVKFKRQfvpIKVEQIEAKVLVeftDSTNGIeeEYDTVLLAIGRDAC--TRKLNLENVG 290

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446604727  250 ------SGRVVLTKYH--NIPnneHVYVVGDCA 274
Cdd:TIGR01438 291 vkinkkTGKIPADEEEqtNVP---YIYAVGDIL 320
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
144-272 4.98e-03

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 38.60  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 144 TVAVVGAGLSGVEVASELREsrSDLKIYLFDRKDRIL-FPYPE---KLSRYveewFVKHKVTIIRNSNITKVE--PNIVY 217
Cdd:PRK05249 177 SLIIYGAGVIGCEYASIFAA--LGVKVTLINTRDRLLsFLDDEisdALSYH----LRDSGVTIRHNEEVEKVEggDDGVI 250

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446604727 218 NHDEP---LECDAIVWTAGIQANEVVRNLP---VEQDGSGRVVLTKYHNIPnNEHVYVVGD 272
Cdd:PRK05249 251 VHLKSgkkIKADCLLYANGRTGNTDGLNLEnagLEADSRGQLKVNENYQTA-VPHIYAVGD 310
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 63-272 5.17e-03

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 38.61  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727  63 PFPEHPRLNIQYGTVTNIDLEEKAVHLDggeaiQYDDLIIGLGCEdkyHNVPGAK-EYTHSLQSIEQTrktyEQLNSLEP 141
Cdd:PRK13512  77 TYHEVIAINDERQTVTVLNRKTNEQFEE-----SYDKLILSPGAS---ANSLGFEsDITFTLRNLEDT----DAIDQFIK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 142 NATVA---VVGAGLSGVEVASELREsrSDLKIYLFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEPNIVYN 218
Cdd:PRK13512 145 ANQVDkalVVGAGYISLEVLENLYE--RGLHPTLIHRSDKINKLMDADMNQPILDELDKREIPYRLNEEIDAINGNEVTF 222

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446604727 219 HDEPLE-CDAIVWTAGIQAN-EVVRNLPVEQDGSGRVVLTKYH--NIPNnehVYVVGD 272
Cdd:PRK13512 223 KSGKVEhYDMIIEGVGTHPNsKFIESSNIKLDDKGFIPVNDKFetNVPN---IYAIGD 277
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 145-283 9.29e-03

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 37.82  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 145 VAVVGAGLSGVEVASELRESRSDLKIylFDRKDRILFPYPEKLSRYVEEWFVKHKVTIIRNSNITKVEP--NIVYNHDEP 222
Cdd:PRK06416 175 LVVIGGGYIGVEFASAYASLGAEVTI--VEALPRILPGEDKEISKLAERALKKRGIKIKTGAKAKKVEQtdDGVTVTLED 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446604727 223 ------LECDAIVWTAGIQAN-----------EVVRNLpVEQDGSGRVvltkyhNIPnneHVYVVGDCAA---LPHAPSA 282
Cdd:PRK06416 253 ggkeetLEADYVLVAVGRRPNtenlgleelgvKTDRGF-IEVDEQLRT------NVP---NIYAIGDIVGgpmLAHKASA 322


                 .
gi 446604727 283 Q 283
Cdd:PRK06416 323 E 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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