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Conserved domains on  [gi|446606501|ref|WP_000683847|]
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MULTISPECIES: F510_1955 family glycosylhydrolase [Bacillus]

Protein Classification

WD40/YVTN/BNR-like repeat-containing protein( domain architecture ID 11468233)

WD40/YVTN/BNR-like repeat-containing protein similar to plant photosynthesis system II assembly factor Ycf48, and some glycosylhydrolases

PubMed:  18550538|21531723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 128-252 2.10e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


:

Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 58.47  E-value: 2.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606501 128 GLLKSSDGGNTLEKLA-FYGESDFHNLAIGyNTEAIYLYNErpnsklQQGFYFSTNNGQDWENSKLKGLSSTIHSFSVHP 206
Cdd:COG4447   14 GILRSTDGGKTWTPLSdGLPGLSLRAVAFS-DPNTVWVGTG------PGGIYRSTDGGKTWTEVNSGPDNPRLFAIAFSD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446606501 207 NQSSVVAVsakDGVYLSTDYGNTFEIFAKSLES--TAITLSNEDVIYA 252
Cdd:COG4447   87 PNTGYAAV---GGIYRTTDGGKTWTKVSSGLPVdlNDVAFLDPGTLYA 131
 
Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 128-252 2.10e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 58.47  E-value: 2.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606501 128 GLLKSSDGGNTLEKLA-FYGESDFHNLAIGyNTEAIYLYNErpnsklQQGFYFSTNNGQDWENSKLKGLSSTIHSFSVHP 206
Cdd:COG4447   14 GILRSTDGGKTWTPLSdGLPGLSLRAVAFS-DPNTVWVGTG------PGGIYRSTDGGKTWTEVNSGPDNPRLFAIAFSD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446606501 207 NQSSVVAVsakDGVYLSTDYGNTFEIFAKSLES--TAITLSNEDVIYA 252
Cdd:COG4447   87 PNTGYAAV---GGIYRTTDGGKTWTKVSSGLPVdlNDVAFLDPGTLYA 131
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 177-318 8.07e-05

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 44.11  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606501  177 FYFSTNNGQDWENSKLKGLSSTIHSFSVHPNQSSVVAVSAKDG-VYLSTDYGNTFeifakslestaitlsnedviyapin 255
Cdd:pfam15902   3 VYRSHDYGKTWKKVKDVPDGEAILAIYPHPYDNDRAYLLTDGKkHYYTTDRGKTF------------------------- 57

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446606501  256 kqivtkKSIATNEETNIQIPPL----DPKDTIMYisqnpqNSAEIVFATMKANVFLSTDEGNTWKQI 318
Cdd:pfam15902  58 ------RSFKLPFPPNLFGPPLsfhpKDPDWLIW------YGGKCFSGDCHSVAYYSTDGGKSWKLL 112
VPS10 smart00602
VPS10 domain;
177-234 4.27e-03

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 38.93  E-value: 4.27e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446606501   177 FYFSTNNGQDWENSKLKGLSStIHSFSVHP-NQSSVVAVSAKDG--VYLSTDYGNTFEIFA 234
Cdd:smart00602  12 VYISEDYGKTWKKIDEIEGVI-IETVISDFfNSSANKFKTILVKgyIFISSDEGKSFQKFT 71
 
Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 128-252 2.10e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 58.47  E-value: 2.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606501 128 GLLKSSDGGNTLEKLA-FYGESDFHNLAIGyNTEAIYLYNErpnsklQQGFYFSTNNGQDWENSKLKGLSSTIHSFSVHP 206
Cdd:COG4447   14 GILRSTDGGKTWTPLSdGLPGLSLRAVAFS-DPNTVWVGTG------PGGIYRSTDGGKTWTEVNSGPDNPRLFAIAFSD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446606501 207 NQSSVVAVsakDGVYLSTDYGNTFEIFAKSLES--TAITLSNEDVIYA 252
Cdd:COG4447   87 PNTGYAAV---GGIYRTTDGGKTWTKVSSGLPVdlNDVAFLDPGTLYA 131
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 128-230 9.41e-06

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 44.99  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606501 128 GLLKSSDGGNTLEKLAFYGESDFHNlaigynteAIYLYNERPNSKLQQGFYFSTNNGQDWENSKLkGLSSTIHSFSVHPN 207
Cdd:COG4447   56 GIYRSTDGGKTWTEVNSGPDNPRLF--------AIAFSDPNTGYAAVGGIYRTTDGGKTWTKVSS-GLPVDLNDVAFLDP 126

                         90       100       110
                 ....*....|....*....|....*....|
gi 446606501 208 Q-------SSVVAVSAKDGVYLSTDYGNTF 230
Cdd:COG4447  127 GtlyaageGGLIYRSTDGGEYRSTDGGKTW 156
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 177-318 8.07e-05

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 44.11  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606501  177 FYFSTNNGQDWENSKLKGLSSTIHSFSVHPNQSSVVAVSAKDG-VYLSTDYGNTFeifakslestaitlsnedviyapin 255
Cdd:pfam15902   3 VYRSHDYGKTWKKVKDVPDGEAILAIYPHPYDNDRAYLLTDGKkHYYTTDRGKTF------------------------- 57

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446606501  256 kqivtkKSIATNEETNIQIPPL----DPKDTIMYisqnpqNSAEIVFATMKANVFLSTDEGNTWKQI 318
Cdd:pfam15902  58 ------RSFKLPFPPNLFGPPLsfhpKDPDWLIW------YGGKCFSGDCHSVAYYSTDGGKSWKLL 112
VPS10 smart00602
VPS10 domain;
177-234 4.27e-03

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 38.93  E-value: 4.27e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446606501   177 FYFSTNNGQDWENSKLKGLSStIHSFSVHP-NQSSVVAVSAKDG--VYLSTDYGNTFEIFA 234
Cdd:smart00602  12 VYISEDYGKTWKKIDEIEGVI-IETVISDFfNSSANKFKTILVKgyIFISSDEGKSFQKFT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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