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Conserved domains on  [gi|446607928|ref|WP_000685274|]
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MULTISPECIES: Tn3 family transposase, partial [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDE_Tnp_Tn3 super family cl46769
Tn3 transposase DDE domain; This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, ...
 1-74 7.48e-27

Tn3 transposase DDE domain; This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.


The actual alignment was detected with superfamily member COG4644:

Pssm-ID: 481109  Cd Length: 490  Bit Score: 100.87  E-value: 7.48e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446607928   1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDYVWRQSRRLEDgkFRPLRMPGKP 74
Cdd:COG4644  416 LNLVANAIVLWNTLYLQRALEELRAEGDEIPDELLAHLSPLGWEHINLTGDYDFDLERKLGG--LRPLRAPLAL 487
 
Name Accession Description Interval E-value
COG4644 COG4644
Transposase and inactivated derivatives, TnpA family [Mobilome: prophages, transposons];
1-74 7.48e-27

Transposase and inactivated derivatives, TnpA family [Mobilome: prophages, transposons];


Pssm-ID: 443682  Cd Length: 490  Bit Score: 100.87  E-value: 7.48e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446607928   1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDYVWRQSRRLEDgkFRPLRMPGKP 74
Cdd:COG4644  416 LNLVANAIVLWNTLYLQRALEELRAEGDEIPDELLAHLSPLGWEHINLTGDYDFDLERKLGG--LRPLRAPLAL 487
transpos_Tn3 NF033527
Tn3 family transposase;
1-55 1.53e-23

Tn3 family transposase;


Pssm-ID: 468061 [Multi-domain]  Cd Length: 954  Bit Score: 91.56  E-value: 1.53e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446607928   1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDYVWR 55
Cdd:NF033527 900 LNLVANAIVLWNTLYLQRALTHLRARGQTIPDELLRRLSPLGWEHINLTGDYLFT 954
DDE_Tnp_Tn3 pfam01526
Tn3 transposase DDE domain; This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, ...
 1-52 9.89e-22

Tn3 transposase DDE domain; This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.


Pssm-ID: 426307  Cd Length: 389  Bit Score: 86.02  E-value: 9.89e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446607928    1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDY 52
Cdd:pfam01526 338 LNLVANAIVLWNTVYLQRALEQLRAEGEDVTDEDLARLSPLGWEHINLFGRY 389
 
Name Accession Description Interval E-value
COG4644 COG4644
Transposase and inactivated derivatives, TnpA family [Mobilome: prophages, transposons];
1-74 7.48e-27

Transposase and inactivated derivatives, TnpA family [Mobilome: prophages, transposons];


Pssm-ID: 443682  Cd Length: 490  Bit Score: 100.87  E-value: 7.48e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446607928   1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDYVWRQSRRLEDgkFRPLRMPGKP 74
Cdd:COG4644  416 LNLVANAIVLWNTLYLQRALEELRAEGDEIPDELLAHLSPLGWEHINLTGDYDFDLERKLGG--LRPLRAPLAL 487
transpos_Tn3 NF033527
Tn3 family transposase;
1-55 1.53e-23

Tn3 family transposase;


Pssm-ID: 468061 [Multi-domain]  Cd Length: 954  Bit Score: 91.56  E-value: 1.53e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446607928   1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDYVWR 55
Cdd:NF033527 900 LNLVANAIVLWNTLYLQRALTHLRARGQTIPDELLRRLSPLGWEHINLTGDYLFT 954
DDE_Tnp_Tn3 pfam01526
Tn3 transposase DDE domain; This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, ...
 1-52 9.89e-22

Tn3 transposase DDE domain; This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.


Pssm-ID: 426307  Cd Length: 389  Bit Score: 86.02  E-value: 9.89e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446607928    1 LNLVTAAIVLWNTVYLERATQGLVEAGKPVDGELLQFLSPLGWEHINLTGDY 52
Cdd:pfam01526 338 LNLVANAIVLWNTVYLQRALEQLRAEGEDVTDEDLARLSPLGWEHINLFGRY 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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