|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
75-354 |
3.22e-71 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 227.13 E-value: 3.22e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 75 RLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKESIENEKKSQEMKNEMISNISHDLRTPVTSLIGYAD 154
Cdd:COG5002 109 ALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLE 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 155 LLGNKLHSNGEECEQYVSILKRKSYELKNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIK- 233
Cdd:COG5002 189 LLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDl 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 234 GDKELHVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHT 313
Cdd:COG5002 269 PEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRET 348
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446617939 314 GGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALPQHKK 354
Cdd:COG5002 349 GGTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
117-353 |
9.73e-69 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 215.54 E-value: 9.73e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 117 LKESIENEKKSQEMKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNGEECEQYVSILKRKSYELKNQVDDLLEYCQINY 196
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 197 REIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDKEL-HVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKR 275
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446617939 276 DMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSshTGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALPQHK 353
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
125-350 |
7.58e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 193.20 E-value: 7.58e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 125 KKSQEMKNEMISNISHDLRTPVTSLIGYADLLgnkLHSNGEECEQYVSILKRKSYELKNQVDDLLEYCQINYREIELHKS 204
Cdd:COG0642 104 EEANEAKSRFLANVSHELRTPLTAIRGYLELL---LEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 205 VVNMKALMEQIMIDFVPQLDDADMSLCIKGDKEL-HVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEI 283
Cdd:COG0642 181 PVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISV 260
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446617939 284 KNFGQCIPDENLPYVFEKFYRGEKSRssHTGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:COG0642 261 EDTGPGIPPEDLERIFEPFFRTDPSR--RGGGTGLGLAIVKRIVELHGGTIEVESEPGKgTTFTVTLP 326
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
102-350 |
2.52e-37 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 139.44 E-value: 2.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 102 EIGELAANVNRMAKSLKESIEneKKSQemkneMISNISHDLRTPVTSLIGYADLLGNK----------LHSNGEEceqyv 171
Cdd:TIGR01386 219 ELRELAQSFNAMLGRLEDAFQ--RLSQ-----FSADLAHELRTPLTNLLGQTQVALSQprtgeeyrevLESNLEE----- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 172 siLKRksyeLKNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDKELHVemDVALMVRLF 251
Cdd:TIGR01386 287 --LER----LSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRG--DPQMFRRAI 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 252 ENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHK 331
Cdd:TIGR01386 359 SNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHG 438
|
250
....*....|....*....
gi 446617939 332 GDITVRSNEKETVFTIALP 350
Cdd:TIGR01386 439 GRASAESPDGKTRFILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
101-353 |
1.36e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 135.30 E-value: 1.36e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 101 DEIGELAANVNRMAKSLKESIEN-EKKSQEMknEMISNI-SHDLRTPVTSLIGYADLLGNKLHSN-GEECEQYVSILKRK 177
Cdd:COG4251 252 LELLELRLELEELEEELEERTAElERSNEEL--EQFAYVaSHDLREPLRKISGFSQLLEEDYGDKlDEEGREYLERIRDA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 178 SYELKNQVDDLLEYCQINYREIELHKsvVNMKALMEQIMIDFVPQLDDADMSLCIkgDKELHVEMDVALMVRLFENVISN 257
Cdd:COG4251 330 AERMQALIDDLLAYSRVGRQELEFEP--VDLNELLEEVLEDLEPRIEERGAEIEV--GPLPTVRGDPTLLRQVFQNLISN 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 258 SIMYGKDGK--EIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGekSRSSHTGGKGMGLAIARSIAELHKGDIT 335
Cdd:COG4251 406 AIKYSRPGEppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRL--HSRDEYEGTGIGLAIVKKIVERHGGRIW 483
|
250
....*....|....*....
gi 446617939 336 VRSNEKE-TVFTIALPQHK 353
Cdd:COG4251 484 VESEPGEgATFYFTLPKAP 502
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
46-334 |
7.87e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 132.64 E-value: 7.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 46 EEKYSFLYFIVFLIFTTTYFACMTKTMMKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKesienek 125
Cdd:NF012163 162 QKRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLE------- 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 126 KSQEMKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNGEEceqYVSILKRKSYELKNQVDDLLEYCQINYREIELHKSV 205
Cdd:NF012163 235 KNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKFTPE---SLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKAS 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 206 VNMKALMEQIMIDFVPQLDDADMSLCIKGDKELHVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKN 285
Cdd:NF012163 312 VDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVAD 391
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446617939 286 FGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDI 334
Cdd:NF012163 392 SAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTL 440
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
49-354 |
1.45e-34 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 131.24 E-value: 1.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 49 YSFLYFIVFL--IFTTTYFAcmtKTMMKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKES------ 120
Cdd:COG5000 11 LLLIALLLLLlaLWLALLLA---RRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQreelee 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 --------------------------------------------------------------------------------
Cdd:COG5000 88 rrryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgr 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 121 ---------------------IENEKKSQEMKN--EMISNISHDLRTPVTSLIGYADLLGNKLHSNGEEC----EQYVSI 173
Cdd:COG5000 168 rtllvrasplrddgyvivfddITELLRAERLAAwgELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDredlERALDT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 174 LKRKSYELKNQVDDLLEYCqinyREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDKEL-HVEMDVALMVRLFE 252
Cdd:COG5000 248 IIRQVDRLKRIVDEFLDFA----RLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKG 332
Cdd:COG5000 324 NLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGG 397
|
410 420
....*....|....*....|...
gi 446617939 333 DITVRSNE-KETVFTIALPQHKK 354
Cdd:COG5000 398 TIELESRPgGGTTFTIRLPLAEE 420
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
100-352 |
8.79e-29 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 114.51 E-value: 8.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 100 NDEIGELAANVNRMAKSLKESIENEKK---SQEMK--NEMISNISHDLRTPVTSLIGYADLLGNKLHSNG--EECEQYVS 172
Cdd:COG4191 106 NAELEELERDITELERAEEELRELQEQlvqSEKLAalGELAAGIAHEINNPLAAILGNAELLRRRLEDEPdpEELREALE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 173 ILKRKSYELKNQVDDLLEYcqinYREIELHKSVVNMKALMEQiMIDFV-PQLDDADMSLCIKGDKELH-VEMDVALMVRL 250
Cdd:COG4191 186 RILEGAERAAEIVRSLRAF----SRRDEEEREPVDLNELIDE-ALELLrPRLKARGIEVELDLPPDLPpVLGDPGQLEQV 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 251 FENVISNSI--MYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFY----RGEksrsshtgGKGMGLAIAR 324
Cdd:COG4191 261 LLNLLINAIdaMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkpVGK--------GTGLGLSISY 332
|
250 260
....*....|....*....|....*....
gi 446617939 325 SIAELHKGDITVRSNEKE-TVFTIALPQH 352
Cdd:COG4191 333 GIVEKHGGRIEVESEPGGgTTFTITLPLA 361
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
242-350 |
8.82e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 102.34 E-value: 8.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 242 MDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGeKSRSSHTGGKGMGLA 321
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-DKRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 446617939 322 IARSIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGgTTFTITLP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-350 |
2.16e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 100.92 E-value: 2.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRssHTGGKGMGLAIARSI 326
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....
gi 446617939 327 AELHKGDITVRSNEKETVFTIALP 350
Cdd:cd16923 79 IELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
76-352 |
2.95e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 109.09 E-value: 2.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 76 LSEINKNVKEIRNGNFEVYI-----PIskndEIGELAANVNRMAkslkESIENEKKSQemkNEMISNISHDLRTPVTSLI 150
Cdd:PRK09835 213 IRSVSRQIQNITSKDLDVRLdpqtvPI----ELEQLVLSFNHMI----ERIEDVFTRQ---SNFSADIAHEIRTPITNLI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 151 GYADL----------LGNKLHSNGEEceqyvsiLKRKSyelkNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFV 220
Cdd:PRK09835 282 TQTEIalsqsrsqkeLEDVLYSNLEE-------LTRMA----KMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFE 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 221 PQLDDADMSLCIKGdKELHVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFE 300
Cdd:PRK09835 351 AWAEERGVELRFVG-DPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFD 429
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 446617939 301 KFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRSNEKETVFTIALPQH 352
Cdd:PRK09835 430 RFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPRL 481
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
106-353 |
3.96e-26 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 109.74 E-value: 3.96e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 106 LAAN-VNRMAksLKESIENEKKSQE---MKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNGEECEQYVSILKRKSYEL 181
Cdd:PRK10490 637 LIANaLERLT--LTASEEQARLASEreqLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNT 714
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 182 KNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDKELhVEMDVALMVRLFENVISNSIMY 261
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTL-IHVDGPLFERVLINLLENAVKY 793
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 262 GKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKsrSSHTGGKGMGLAIARSIAELHKGDITVRSNEK 341
Cdd:PRK10490 794 AGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNK--ESAIPGVGLGLAICRAIVEVHGGTIWAENRPE 871
|
250
....*....|...
gi 446617939 342 -ETVFTIALPQHK 353
Cdd:PRK10490 872 gGACFRVTLPLET 884
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
133-354 |
1.51e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 105.31 E-value: 1.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 133 EMISNISHDLRTPVTSLIGYADLLGNKLHSngEECEQYVSILKRKSYELKNQVDDLLEYcqinYREIELHKSVVNMKALM 212
Cdd:COG3852 137 ELAAGLAHEIRNPLTGIRGAAQLLERELPD--DELREYTQLIIEEADRLNNLVDRLLSF----SRPRPPEREPVNLHEVL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 213 EQImIDFVPQLDDADMSLCIKGDKEL-HVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKR----------DMNVEI 281
Cdd:COG3852 211 ERV-LELLRAEAPKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlgglrpRLYVRI 289
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446617939 282 EIKNFGQCIPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSNE-KETVFTIALPQHKK 354
Cdd:COG3852 290 EVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPgKGTTFRIYLPLEQA 357
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
89-335 |
2.34e-25 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 106.26 E-value: 2.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 89 GNFEVYIPISKNDEIGELAANVNRMAKSLKesienekKSQEMKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNGEECe 168
Cdd:PRK10549 205 GDFTTRVTPTSRDELGRLAQDFNQLASTLE-------KNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPES- 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 169 qyVSILKRKSYELKNQVDDL--LEYCQ---INYReielhKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDKELHVEMD 243
Cdd:PRK10549 277 --VASLQAEVGTLTKLVDDLhqLSLSDegaLAYR-----KTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGD 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 244 VALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIA 323
Cdd:PRK10549 350 PDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAIC 429
|
250
....*....|..
gi 446617939 324 RSIAELHKGDIT 335
Cdd:PRK10549 430 LNIVEAHNGRII 441
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
96-352 |
3.50e-22 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 97.22 E-value: 3.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 96 PISKNDEIGELAANVNRMAKSL--KESIENekksqemkneMISNISHDLRTPVTSLIGYADLLGNKLhsNGEECEQYVSI 173
Cdd:PRK11100 229 PKLGSSELRELAQALESMRVKLegKAYVEQ----------YVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGN 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 174 LKRKSYELKNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDkELHVEMDVALMVRLFEN 253
Cdd:PRK11100 297 ILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGN 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 254 VISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFY---RGEKSRSShtggKGMGLAIARSIAELH 330
Cdd:PRK11100 376 LLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRKS----TGLGLAFVREVARLH 451
|
250 260
....*....|....*....|....
gi 446617939 331 KGDITVRsN--EKETVFTIALPQH 352
Cdd:PRK11100 452 GGEVTLR-NrpEGGVLATLTLPRH 474
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
111-340 |
1.58e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 95.06 E-value: 1.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 111 NRMAKSLKESIENEKksqemknEMISNISHDLRTPVTSLIGYADLLGNKlhsngEECEQyvSILKRKSYELKNQVDDLLE 190
Cdd:PRK10604 199 NQMADNINALIASKK-------QLIDGIAHELRTPLVRLRYRLEMSDNL-----SAAES--QALNRDIGQLEALIEELLT 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 191 YCQINYREIELHKSVVNMKALMEQIMIDFvpQLddadmslcIKGDKELHVEM---------DVALMVRLFENVISNSIMY 261
Cdd:PRK10604 265 YARLDRPQNELHLSEPDLPAWLSTHLADI--QA--------VTPEKTVRLDTphqgdygalDMRLMERVLDNLLNNALRY 334
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446617939 262 GkdGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRSNE 340
Cdd:PRK10604 335 A--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE 411
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
242-350 |
2.50e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 87.42 E-value: 2.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 242 MDVALMVRLFENVISNSIMYGKDGKEIVIQVSkRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRsshTGGKGMGLA 321
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRG---GGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 446617939 322 IARSIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGgTTVTLTLP 106
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-334 |
1.13e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 85.98 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 249 RLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAE 328
Cdd:cd16946 7 QLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNIAL 86
|
....*.
gi 446617939 329 LHKGDI 334
Cdd:cd16946 87 AHGGTI 92
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
235-349 |
1.48e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 83.33 E-value: 1.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 235 DKELHVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTG 314
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQ 88
|
90 100 110
....*....|....*....|....*....|....*.
gi 446617939 315 GKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIAL 349
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSKPYEkTVFTVTL 124
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
79-350 |
8.51e-18 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 84.69 E-value: 8.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 79 INKNVKEirngNFEVYIPISKNDEIGELAANVNRMAKSLKESIEN-EKK----SQEM-------------KNEMISNISH 140
Cdd:PRK15347 332 INKTGPA----ALEPRLPENRLDELGSIAKAYNQLLDTLNEQYDTlENKvaerTQALaeakqraeqankrKSEHLTTISH 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 141 DLRTPVTSLIGYADLLGN--------KLHSNGEECEQYVSILkrksyelknqVDDLLEYCQINYREIELHKSVVNMKALM 212
Cdd:PRK15347 408 EIRTPLNGVLGALELLQNtpltaeqmDLADTARQCTLSLLAI----------INNLLDFSRIESGQMTLSLEETALLPLL 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 213 EQIMIDFVPQLDDADMSL-CIKGDK-ELHVEMDvALMVR-LFENVISNSIMYGKDGkEIVIQVSKRDMNVEIEIKNFGQC 289
Cdd:PRK15347 478 DQAMLTIQGPAQSKSLTLrTFVGAHvPLYLHLD-SLRLRqILVNLLGNAVKFTETG-GIRLRVKRHEQQLCFTVEDTGCG 555
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446617939 290 IPDENLPYVFEKFYRGEksrsSHTGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:PRK15347 556 IDIQQQQQIFTPFYQAD----THSQGTGLGLTIASSLAKMMGGELTLFSTPGVgSCFSLVLP 613
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
130-352 |
1.88e-17 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 82.75 E-value: 1.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 130 MKNEMISNISHDLRTPVTSLIGYADLLGNKlHSNGEECEQYVSILKRKSYELKNQVDDLLEYCQINYREIELHKSVVNMK 209
Cdd:PRK11006 203 ARRNFFANVSHELRTPLTVLQGYLEMMQDQ-PLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 210 ALMEqimidfVPQLDDADMSlciKGDKELHVEMDVALMVRLFE--------NVISNSIMYGKDGKEIVIQVSKRDMNVEI 281
Cdd:PRK11006 282 MMLR------VLEREAQTLS---QGKHTITFEVDNSLKVFGNEdqlrsaisNLVYNAVNHTPEGTHITVRWQRVPQGAEF 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446617939 282 EIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRSNE-KETVFTIALPQH 352
Cdd:PRK11006 353 SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVgKGTRFSFVLPER 424
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
121-350 |
3.02e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 82.72 E-value: 3.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 121 IENEKKSQEMKN---------EMISNISHDLRTPVTSLIGYADLLgnkLHSNGEECEQYVSILKRKSYELKNQVDDLLEY 191
Cdd:COG5809 251 ITERKKLEELLRkseklsvvgELAAGIAHEIRNPLTSLKGFIQLL---KDTIDEEQKTYLDIMLSELDRIESIISEFLVL 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 192 CQ---INYREIELHK------SVVNMKALMEQIMIDFVPQLDDADmslcikgdkelhVEMDVALMVRLFENVISNSIMYG 262
Cdd:COG5809 328 AKpqaIKYEPKDLNTlieeviPLLQPQALLKNVQIELELEDDIPD------------ILGDENQLKQVFINLLKNAIEAM 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 263 KDGKEIVIQVSKRDMN-VEIEIKNFGQCIPDENLPYVFEKFY-RGEKsrsshtgGKGMGLAIARSIAELHKGDITVRSNE 340
Cdd:COG5809 396 PEGGNITIETKAEDDDkVVISVTDEGCGIPEERLKKLGEPFYtTKEK-------GTGLGLMVSYKIIEEHGGKITVESEV 468
|
250
....*....|.
gi 446617939 341 -KETVFTIALP 350
Cdd:COG5809 469 gKGTTFSITLP 479
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
89-334 |
9.61e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 81.13 E-value: 9.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 89 GNFEvyipISKNDEIG-----ELAANVNRMAKSLKESIENEKKsqemkneMISNISHDLRTPVTSLIGYADLLGNKlhsN 163
Cdd:PRK09470 207 GNLR----QHPELETGpqefrQAGASFNQMVTALERMMTSQQR-------LLSDISHELRTPLTRLQLATALLRRR---Q 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 164 GEECEqyvsiLKRKSYE---LKNQVDDLLEYC--QINYreiELHKSVVNMKALMEQImidfvpqLDDADMSLCIKGdKEL 238
Cdd:PRK09470 273 GESKE-----LERIETEaqrLDSMINDLLVLSrnQQKN---HLERETFKANSLWSEV-------LEDAKFEAEQMG-KSL 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 239 HVEMDV---------ALMVRLFENVISNSIMYGKDGKEIVIQVSKRDmnVEIEIKNFGQCIPDENLPYVFEKFYRGEKSR 309
Cdd:PRK09470 337 TVSAPPgpwpingnpNALASALENIVRNALRYSHTKIEVAFSVDKDG--LTITVDDDGPGVPEEEREQIFRPFYRVDEAR 414
|
250 260
....*....|....*....|....*
gi 446617939 310 SSHTGGKGMGLAIARSIAELHKGDI 334
Cdd:PRK09470 415 DRESGGTGLGLAIVENAIQQHRGWV 439
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-351 |
2.28e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 74.16 E-value: 2.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 251 FENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELH 330
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|..
gi 446617939 331 KGDITVRSNE-KETVFTIALPQ 351
Cdd:cd16952 85 DARLLIASELgKGSRFTCLFPS 106
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
249-350 |
2.46e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 73.90 E-value: 2.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 249 RLFENVISNSIMYGKdgKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAE 328
Cdd:cd16949 3 RALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 446617939 329 LHKGDITVrSNEKET--VFTIALP 350
Cdd:cd16949 81 QHGGKIKA-SNRKPGglRVRIWLP 103
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-350 |
1.07e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 72.32 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 243 DVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTgGKGMGLAI 322
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYL 80
|
90 100 110
....*....|....*....|....*....|.
gi 446617939 323 ARSIAE--LHKgdITVRSNEKE-TVFTIALP 350
Cdd:cd16948 81 VKKLCDklGHK--IDVESEVGEgTTFTITFP 109
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
253-350 |
1.08e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 72.14 E-value: 1.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSIMYGKDGkEIVIQVSKRDM-----NVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIA 327
Cdd:cd16922 7 NLLGNAIKFTEEG-EVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLV 85
|
90 100
....*....|....*....|....
gi 446617939 328 ELHKGDITVRSNEKE-TVFTIALP 350
Cdd:cd16922 86 ELMGGDISVESEPGQgSTFTFTLP 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
76-341 |
2.24e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 76.87 E-value: 2.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 76 LSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKEsIENEKksqemkNEMISNISHDLRTPVTSLigyadl 155
Cdd:PRK09467 181 LVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQ-LEDDR------TLLMAGVSHDLRTPLTRI------ 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 156 lgnklhsngeeceqyvsilkRKSYELKNQVDDLLEYcQINYrEIElhksvvNMKALMEQiMIDFVPQLDDADMSLC---- 231
Cdd:PRK09467 248 --------------------RLATEMMSEEDGYLAE-SINK-DIE------ECNAIIEQ-FIDYLRTGQEMPMEMAdlna 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 232 -------IKGDKELHVEMDVAL-----------MVRLFENVISNSIMYGKDgkEIVIQvSKRDMN-VEIEIKNFGQCIPD 292
Cdd:PRK09467 299 llgeviaAESGYEREIETALQPgpievpmnpiaIKRALANLVVNAARYGNG--WIKVS-SGTEGKrAWFQVEDDGPGIPP 375
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446617939 293 ENLPYVFEKFYRGEKSRSSHtgGKGMGLAIARSIAELHKGDITVRSNEK 341
Cdd:PRK09467 376 EQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEE 422
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
133-354 |
2.35e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 76.93 E-value: 2.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 133 EMISNISHDLRTPVTSLIGYADLLGNKlhSNGEECEQYVSILKRKSYELKNQVDDLLEYCqinyREIELHKSVVNMKALM 212
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQ--TSDPPSQEYLSVVLREVDRLNKVIDQLLEFS----RPRESQWQPVSLNALV 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 213 EQIMIDF--VPQLDDADMSLCIKGDKELhVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSK-RDMNVEIEIKNFGQC 289
Cdd:PRK11360 466 EEVLQLFqtAGVQARVDFETELDNELPP-IWADPELLKQVLLNILINAVQAISARGKIRIRTWQySDGQVAVSIEDNGCG 544
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446617939 290 IPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALPQHKK 354
Cdd:PRK11360 545 IDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVgTTFTLYLPINPQ 604
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
133-350 |
6.08e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 72.46 E-value: 6.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 133 EMISNISHDLRTPVTSLIGYADLLGNKLHSNGE-------ECEQYVSILkrksYEL----KNQVDDLlEYCQINyreiEL 201
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEyfdimlsELDRIESII----SEFlalaKPQAVNK-EKENIN----EL 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 202 HKSVV---NMKALMEQIMIDFvpQLDDADMslCIKGD-KELHvemdvalmvRLFENVISNSIMYGKDGKEIVIQVSKRDM 277
Cdd:COG5805 360 IQDVVtllETEAILHNIQIRL--ELLDEDP--FIYCDeNQIK---------QVFINLIKNAIEAMPNGGTITIHTEEEDN 426
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446617939 278 NVEIEIKNFGQCIPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSN-EKETVFTIALP 350
Cdd:COG5805 427 SVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKvGKGTTFTITLP 494
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-337 |
1.40e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 66.33 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 243 DVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKsrsSHTGGK--GMGL 320
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPR---PHSGQKstGLGL 77
|
90
....*....|....*..
gi 446617939 321 AIARSIAELHKGDITVR 337
Cdd:cd16945 78 AFVQEVAQLHGGRITLR 94
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
124-350 |
1.94e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 71.51 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 124 EKKSQEmKNEMISNISHDLRTPVTSLIGYAD-LLGNKLHSngeECEQYVSILKRKSYELKNQVDDLLEYCQINYREIELH 202
Cdd:PRK11091 277 EKASRD-KTTFISTISHELRTPLNGIVGLSRiLLDTELTA---EQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLD 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 203 KSVVNMKalmeqimiDFVPQLDDadMSLCIKGDKELHVEMDVALMV---------RLFE---NVISNSIMYGKDGkEIVI 270
Cdd:PRK11091 353 NQPIDFT--------DFLADLEN--LSGLQAEQKGLRFDLEPLLPLphkvitdgtRLRQilwNLISNAVKFTQQG-GVTV 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 271 QVSkRDMNVEI--EIKNFGQCIPDENLPYVFEKFYRGEKSRSS-HTGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFT 346
Cdd:PRK11091 422 RVR-YEEGDMLtfEVEDSGIGIPEDELDKIFAMYYQVKDSHGGkPATGTGIGLAVSKRLAQAMGGDITVTSEEGKgSCFT 500
|
....
gi 446617939 347 IALP 350
Cdd:PRK11091 501 LTIH 504
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
21-337 |
2.32e-13 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 71.30 E-value: 2.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 21 ILLATVSIIVFQILIGNIYSHVTALEEKYSFLYFIVFLIFTTTYFACMTKTMMKRLSEINKNVKEIRNGNFEVYIPISKN 100
Cdd:COG2770 185 ALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRK 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 101 DEIGELAANVNRMAKSLKESIENEKKSQEMKNEMISNISHDLRTPVTSLIgyADLLGNKLHSNGEECEQYVSILKRKSYE 180
Cdd:COG2770 265 DEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALL--LLLLALLLLAAAALLLELLLLLLLALLL 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 181 LKNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIKGDKELHVEMDVALMVRLFENVISNSIM 260
Cdd:COG2770 343 LLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALL 422
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446617939 261 YGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVR 337
Cdd:COG2770 423 ALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAG 499
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
74-339 |
3.73e-13 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 70.49 E-value: 3.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 74 KRLSEINKNVKEIRNGNFEVYIPISKNDEIGELA-------ANVNRMAKSLKESIEN----EKKSQEMKNEMI------- 135
Cdd:COG4192 353 KRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIArllrvfrDQAIEKTQELETEIEErkriEKNLRQTQDELIqaakmav 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 136 -----SNISHDLRTPVTSLIGYadLLGNKLHSNGEECEQYVSILKrKSYELKNQVDDLLEYCQINYREIELHKSVVNMKA 210
Cdd:COG4192 433 vgqtmTSLAHELNQPLNAMSMY--LFSAKKALEQENYAQLPTSLD-KIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQ 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 211 LMEQIMIDFVPQLDDADMSLCIKGDkeLHVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCI 290
Cdd:COG4192 510 VIEQAWELVESRAKPQQITLHIPDD--LMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW 587
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446617939 291 PDenLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSN 339
Cdd:COG4192 588 PL--VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLAST 628
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-342 |
7.06e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 64.35 E-value: 7.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 234 GDKELhvemdVALMVRlfeNVISNSIMYGKDGKEIVIQVSKRDMNVeIEIKNFGQCIPDENLPYVFEKFYRgekSRSSHT 313
Cdd:cd16940 9 GDALL-----LFLLLR---NLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYR---SDGQNY 76
|
90 100
....*....|....*....|....*....
gi 446617939 314 GGKGMGLAIARSIAELHKGDITVRSNEKE 342
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGG 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
243-350 |
1.00e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.05 E-value: 1.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 243 DVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMN-VEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLA 321
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNrFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 446617939 322 IARSIAELHKGDITV-RSNEKETVFTIALP 350
Cdd:cd16925 81 IVKEFVELHGGTVTVsDAPGGGALFQVELP 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
112-350 |
1.00e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 69.23 E-value: 1.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 112 RMAKSLKE-SIENEKKSQEmKNEMISNISHDLRTPVTSLIGYADLLgnKLHSNGEECEQYVSILKRKSYELKNQVDDLLE 190
Cdd:PRK10841 428 KMEESLQEmAQAAEQASQS-KSMFLATVSHELRTPLYGIIGNLDLL--QTKELPKGVDRLVTAMNNSSSLLLKIISDILD 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 191 YCQINYREIELHKSVVNMKALMEQIMIDFVPqlddadmsLCIKGDKELH--VEMDV--ALM---VRL---FENVISNSIM 260
Cdd:PRK10841 505 FSKIESEQLKIEPREFSPREVINHITANYLP--------LVVKKRLGLYcfIEPDVpvALNgdpMRLqqvISNLLSNAIK 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 261 YGKDGKeIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRSNE 340
Cdd:PRK10841 577 FTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEP 655
|
250
....*....|.
gi 446617939 341 K-ETVFTIALP 350
Cdd:PRK10841 656 GmGSQFTIRIP 666
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-341 |
1.14e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 63.63 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 243 DVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHtGGKGMGLAI 322
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90
....*....|....*....
gi 446617939 323 ARSIAELHKGDITVRSNEK 341
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQK 98
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
13-350 |
2.55e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 67.74 E-value: 2.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 13 FFTAFICSILLATVSIIVFQILIGNIYSHVTALEEKYSFLYFIVFLIFTTTYFAcMTKTMMKRLSEINKNVKEIRNGNFe 92
Cdd:COG2972 123 GLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYL-LSRSITRPIKRLKKAMKKVEKGDL- 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 93 VYIPISKNDEIGELAANVNRMAKSLKESIENEKKSQEMKNEM-----ISNIS-HDLRTPVTSLIGYADLLGNklhsngEE 166
Cdd:COG2972 201 VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAelkalQAQINpHFLFNTLNSIRWLAELEDP------EE 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 167 CEQYVSILkrkSYELKNQVDDLLEYCQINyREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLCIkgdkelhvemdVAL 246
Cdd:COG2972 275 AEEMLEAL---SKLLRYSLSKGDELVTLE-EELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLI-----------PKL 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVR-LFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFyrgeksrSSHTGGKGMGLAIARS 325
Cdd:COG2972 340 ILQpLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRE 412
|
330 340
....*....|....*....|....*....
gi 446617939 326 IAELHKGD---ITVRSNEKE-TVFTIALP 350
Cdd:COG2972 413 RLKLYYGEeygLEIESEPGEgTTVTIRIP 441
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
128-191 |
2.93e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.07 E-value: 2.93e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446617939 128 QEMKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNgEECEQYVSILKRKSYELKNQVDDLLEY 191
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDD-EEQREYLERIREEAERLLRLINDLLDL 63
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
21-350 |
3.28e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 66.80 E-value: 3.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 21 ILLATVSIIVFQILIGNIYSHVTALEEKYSFLYFIVFLIFTTTYFACMTKTMMKRLSEINKNVKE---IRNGNFEVYIPI 97
Cdd:COG3290 21 LLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEEreaVLESIREGVIAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 98 SKNDEIgelaANVNRMAKSLKESIENEKKSQEMKNEMISNISHDL------------RTPVTS---LIGY---------A 153
Cdd:COG3290 101 DRDGRI----TLINDAARRLLGLDAIGRPIDEVLAEVLETGERDEeillngrvlvvnRVPIRDdgrVVGAvatfrdrteL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 154 DLLGNKLHSNgeecEQYVSILKRKSYELKNQVDDLLEYCQINYREiELHKSVVNMKALMEQIMIDFVPQLDDADMS--LC 231
Cdd:COG3290 177 ERLEEELEGV----KELAEALRAQRHDFRNHLHTISGLLQLGEYD-EALEYIDEISEELQELIDSLLSRIGNPVLAalLL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 232 IKGD--KELHVEMDVAL-------------MVRLFENVISNSI----MYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPD 292
Cdd:COG3290 252 GKAAraRERGIDLTIDIdsdlpdlplsdtdLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPE 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446617939 293 ENLPYVFEkfyRGEKSRSSHtgGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:COG3290 332 ELLEKIFE---RGFSTKLGE--GRGLGLALVKQIVEKYGGTIEVESEEGEgTVFTVRLP 385
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
122-350 |
3.49e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 66.90 E-value: 3.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 122 ENEKKSQ--EMKNEMISNISHDLRTPVTSLIGYADLLgnKLHSNGEECEQYVSILKRKSYELKNQVD-------DLLEYC 192
Cdd:PRK09303 140 ENETLLEqlKFKDRVLAMLAHDLRTPLTAASLALETL--ELGQIDEDTELKPALIEQLQDQARRQLEeierlitDLLEVG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 193 QINYREIELHKSVVNMKALMEQIMIDFVPQLDDadmslcikgdKELHVEMDVA-----------LMVRLFENVISNSIMY 261
Cdd:PRK09303 218 RTRWEALRFNPQKLDLGSLCQEVILELEKRWLA----------KSLEIQTDIPsdlpsvyadqeRIRQVLLNLLDNAIKY 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 262 GKDGKEIVIQVSKR-DMNVEIEIKNFGQCIPDENLPYVFEKFYRgeKSRSSHTGGKGMGLAIARSIAELHKGDITVRSNE 340
Cdd:PRK09303 288 TPEGGTITLSMLHRtTQKVQVSICDTGPGIPEEEQERIFEDRVR--LPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEP 365
|
250
....*....|.
gi 446617939 341 KE-TVFTIALP 350
Cdd:PRK09303 366 GQgSCFHFTLP 376
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
138-350 |
3.82e-12 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 67.12 E-value: 3.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 138 ISHDLRTPVTSLIGYADLLGNKLHSNGEEcEQYVSILKRKSYELKNQVDDLLEYCQ---INYREIELHKSVVNMKALMEQ 214
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEA-HQLAQVMAKEADRLNRVVSELLELVKpthLALQAVDLNDLINHSLQLVSQ 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 215 ------IMIDFVPQlddadmslciKGDKELHVEMDVALMVRLfeNVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQ 288
Cdd:PRK10364 323 dansreIQLRFTAN----------DTLPEIQADPDRLTQVLL--NLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGK 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446617939 289 CIPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSNE-KETVFTIALP 350
Cdd:PRK10364 391 GIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEgKGATFTLWLP 447
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-350 |
3.96e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 62.03 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSI--M--YGKDGKEIVIQVSKRDMN-VEIEIKNFGQCIPDENLPYVFEKFYRGEKSrsshtgGKGMGLAIARSIA 327
Cdd:cd16920 7 NLVRNGIeaMseGGCERRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 446617939 328 ELHKGDITVRSNEKE-TVFTIALP 350
Cdd:cd16920 81 EAHGGRLSVESPAGGgATFQFTLP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-340 |
4.62e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 61.70 E-value: 4.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVRLFENVISNSIMYGkdGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSshTGGKGMGLAIARSI 326
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90
....*....|....
gi 446617939 327 AELHKGDITVRSNE 340
Cdd:cd16950 77 SDAHGGSLTLANRA 90
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
130-191 |
1.06e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.53 E-value: 1.06e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446617939 130 MKNEMISNISHDLRTPVTSLIGYADLLGNklHSNGEECEQYVSILKRKSYELKNQVDDLLEY 191
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDL 60
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
21-352 |
1.63e-11 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 65.29 E-value: 1.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 21 ILLATVSIIVFQILIGNIYSHVTALEEKYSFLYFIVFLIFTTTYFACMTKTMMKRLSEINKNVKEIRNGNFEVYIPISKN 100
Cdd:COG3850 91 SLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGR 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 101 DEIGELAANVNRMAKSLKESIENEKKSQEMKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNGEECEQYVSILKRKSYE 180
Cdd:COG3850 171 DELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAE 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 181 --LKNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLDDADMSLcikgDKELHVEMDVALMVRLFENVISNS 258
Cdd:COG3850 251 seLLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAE----EALLLLVELAALLLLLLLQAIANA 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 259 IMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRS 338
Cdd:COG3850 327 SLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDV 406
|
330
....*....|....
gi 446617939 339 NEKETVFTIALPQH 352
Cdd:COG3850 407 EGGVAGEGGLVVLI 420
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-350 |
2.63e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 59.65 E-value: 2.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVE--IEIKNFGQCIPDENLPYVFEKFYRGEkSRSSHtGGKGMGLAIAR 324
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEwtFYVRDNGIGIDPEYAEKVFGIFQRLH-SREEY-EGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 446617939 325 SIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:cd16921 79 KIIERHGGRIWLESEPGEgTTFYFTLP 105
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
130-191 |
5.10e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.58 E-value: 5.10e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446617939 130 MKNEMISNISHDLRTPVTSLIGYADLLgnKLHSNGEECEQYVSILKRKSYELKNQVDDLLEY 191
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELL--LDTELSEEQREYLETILREAERLLRLINDLLDL 60
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
121-350 |
7.36e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 62.79 E-value: 7.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 121 IENEKK-SQEMKN--------EMISNISHDLRTPVTSLIGYADLLGNKLHSngEECEQYVSILKRKSYELKNQVDDLLEY 191
Cdd:PRK11073 111 MDNQRRlSQEQLQhaqqvaarDLVRGLAHEIKNPLGGLRGAAQLLSKALPD--PALTEYTKVIIEQADRLRNLVDRLLGP 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 192 CQINYREIE-LHKSVVNMKALMEQIMIDFVPQLDDADMSLcikgdKELhvEMDVALMVRLFENVISNSI-MYGKDGKEIV 269
Cdd:PRK11073 189 QRPGTHVTEsIHKVAERVVQLVSLELPDNVRLIRDYDPSL-----PEL--AHDPDQIEQVLLNIVRNALqALGPEGGTIT 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 270 I------QVS---KR-DMNVEIEIKNFGQCIPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSN 339
Cdd:PRK11073 262 LrtrtafQLTlhgERyRLAARIDIEDNGPGIPPHLQDTLFYPMV------SGREGGTGLGLSIARNLIDQHSGKIEFTSW 335
|
250
....*....|.
gi 446617939 340 EKETVFTIALP 350
Cdd:PRK11073 336 PGHTEFSVYLP 346
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-350 |
1.07e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 58.20 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 245 ALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSshtgGKGMGLAIAR 324
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 446617939 325 SIAELHKGDITVRSNE-KETVFTIALP 350
Cdd:cd16943 78 RIIQKHGGTIRVASVPgGGTRFTIILP 104
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-350 |
1.25e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.83 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEikNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARSI 326
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVE--DDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 446617939 327 AELHKGDITV-RSNEKETVFTIALP 350
Cdd:cd16939 79 ALWHGGHVECdDSELGGACFRLTWP 103
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
125-350 |
2.65e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 61.84 E-value: 2.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 125 KKSQEMKNEMISNISHDLRTPVTSLIGYADLLGNKLHSNgeECEQYVSILKRKSYELKNQVDDLLEYCQInyrEIELHKS 204
Cdd:PRK11466 438 EKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALN--AQRDDLRAITDSGESLLTILNDILDYSAI---EAGGKNV 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 205 VVNMKALMEQIMIDFVPQLDDADM-SLCIKGDKELHVEMDVALM-----VR-LFENVISNSIMYGKDGkEIVIQVSKRDM 277
Cdd:PRK11466 513 SVSDEPFEPRPLLESTLQLMSGRVkGRPIRLATDIADDLPTALMgdprrIRqVITNLLSNALRFTDEG-SIVLRSRTDGE 591
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446617939 278 NVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRsshtGGKGMGLAIARSIAELHKGDITVRSN-EKETVFTIALP 350
Cdd:PRK11466 592 QWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTpEVGSCFCLRLP 661
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-350 |
4.91e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 56.43 E-value: 4.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVRLFENVISNSIMYG-KDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHTGGKGMGLAIARS 325
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 446617939 326 IAELHKGDITVRSNEKETV-----FTIALP 350
Cdd:cd16953 81 IIEAHGGISVAENHNQPGQvigarFTVQLP 110
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
131-350 |
6.50e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 60.90 E-value: 6.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 131 KNEMISNISHDLRTPVTSLIGYADLLGNKLHSNGEECEQyVSILKRKSYELKNQVDDLLEYCQINYREIELHKSVVNMKA 210
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEA-ISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 211 LMEQIMIDFVPQLDDADMSLCIKGDKELH--VEMDVALMVRLFENVISNSIMYGKDGK-EIVIQVSKRDMN---VEIEIK 284
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNhavIKMTIM 870
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446617939 285 NFGQCIPDENLPYVFEKFyrGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRSNEK-ETVFTIALP 350
Cdd:PRK09959 871 DSGSGLSQEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGiGTTFTITIP 935
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
70-122 |
1.57e-09 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 53.02 E-value: 1.57e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 446617939 70 KTMMKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKESIE 122
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-350 |
2.10e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 54.33 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 247 MVRLFENVISNSI--MYGKDGkEIVIQVS----------KRDMNVEIEIKNFGQCIPDENLPYVFEKFYrgeksrSSHTG 314
Cdd:cd16918 1 LIQVFLNLVRNAAqaLAGSGG-EIILRTRtqrqvtlghpRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGREN 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 446617939 315 GKGMGLAIARSIAELHKGDITVRSNEKETVFTIALP 350
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
73-117 |
2.28e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 52.45 E-value: 2.28e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446617939 73 MKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSL 117
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
pfam00672 |
HAMP domain; |
68-119 |
2.75e-09 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 52.63 E-value: 2.75e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446617939 68 MTKTMMKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKE 119
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
270-350 |
1.82e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 51.52 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 270 IQVSKRDMN--VEIEIKNFGQCIPDENLPYVFEkfyRGEKSRSshTGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFT 346
Cdd:cd16915 26 VEVFLRDEGddLVIEVRDTGPGIAPELRDKVFE---RGVSTKG--QGERGIGLALVRQSVERLGGSITVESEPGGgTTFS 100
|
....
gi 446617939 347 IALP 350
Cdd:cd16915 101 IRIP 104
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
204-350 |
3.66e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 51.83 E-value: 3.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 204 SVVNMKALMEQIMIDFVPQLDDADMSLCIKGDkELHVEMDVAL---MVrLFEnVISNSIMYG----KDGkEIVIQVSKRD 276
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDGP-DVELPADAAVplgLI-LNE-LVTNALKHAflsgEGG-RIRVSWRRED 432
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446617939 277 MNVEIEIKNFGQCIPDEnlpyvfekfyrgeksrSSHTGGKGMGLAIARSIAELHKGDITVRSNEkETVFTIALP 350
Cdd:COG3920 433 GRLRLTVSDNGVGLPED----------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE-GTRVRITFP 489
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
95-348 |
5.44e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 50.74 E-value: 5.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 95 IPI-SKNDEIGELAANVNRMAKSLKESIENEKksqemknEMISNISHDLRTPvtsligyadLLGNKLH------SNGEEC 167
Cdd:PRK10755 107 IAIhSSTLEIEAVTSALNQLVSRLTSTLDQER-------LFTADVAHELRTP---------LAGIRLHlellekQHHIDV 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 168 EQYVSILKRksyeLKNQVDDLLEYCQI-------NYREIELHKSVV--------NMKALMEQIMidfvpQLDDADMSLCI 232
Cdd:PRK10755 171 APLIARLDQ----MMHTVEQLLQLARAgqsfssgHYQTVKLLEDVIlpsqdelsEMLEQRQQTL-----LLPESAADITV 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 233 KGDKELhvemdVALMVRlfeNVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEksrsSH 312
Cdd:PRK10755 242 QGDATL-----LRLLLR---NLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SR 309
|
250 260 270
....*....|....*....|....*....|....*.
gi 446617939 313 TGGKGMGLAIARSIAELHKGDITVrSNEKETVFTIA 348
Cdd:PRK10755 310 YGGIGLGLSIVSRITQLHHGQFFL-QNRQERSGTRA 344
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
68-123 |
8.91e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 50.40 E-value: 8.91e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 446617939 68 MTKTMMKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAANVNRMAKSLKESIEN 123
Cdd:COG0840 202 LSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQ 257
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
134-350 |
5.64e-06 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 48.14 E-value: 5.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 134 MISNISHDLRTPVTSLIGYADLLGNKL--HSNGEECEQYVSILKRKSYELKNQVDDL---LEYCQINYREIELHKSVVNM 208
Cdd:PRK13837 453 LASGIAHNFNNILGAILGYAEMALNKLarHSRAARYIDEIISAGARARLIIDQILAFgrkGERNTKPFDLSELVTEIAPL 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 209 --KALMEQIMIDFvpQLDDADMslcikgdkelHVEMDVALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMN-------- 278
Cdd:PRK13837 533 lrVSLPPGVELDF--DQDQEPA----------VVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshg 600
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 279 -------VEIEIKNFGQCIPDENLPYVFEKFYrgeKSRSshtGGKGMGLAIARSIAELHKGDITVRSNEKE-TVFTIALP 350
Cdd:PRK13837 601 vlppgryVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRgTRFDVYLP 674
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
186-330 |
7.63e-06 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 47.34 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 186 DDLLEYCQINYREIeLHKSVVNMKALMEQIMIDFvpQLDDADMSLCIKGDKELhvemdVALMVRlfeNVISNSIMYGKDG 265
Cdd:PRK10337 303 DNLQDVAEIPLEDL-LQSAVMDIYHTAQQAGIDV--RLTLNAHPVIRTGQPLL-----LSLLVR---NLLDNAIRYSPQG 371
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446617939 266 KEIVIQVSKRdmnvEIEIKNFGQCIPDENLPYVFEKFYR---GEKSrsshtgGKGMGLAIARSIAELH 330
Cdd:PRK10337 372 SVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLH 429
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
253-350 |
2.84e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 45.67 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSI--MYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYrgeksrSSHTGGKGMGLAIARSIAELH 330
Cdd:PRK11086 440 NLIENALeaVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENL 513
|
90 100
....*....|....*....|.
gi 446617939 331 KGDITVRSN-EKETVFTIALP 350
Cdd:PRK11086 514 GGSIAVESEpGVGTQFFVQIP 534
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-349 |
5.06e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 41.67 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSI--MYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYR----GEksrsshtgGKGMGLAIARSI 326
Cdd:cd16976 7 NLLQNALdaMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTtkpvGK--------GTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 446617939 327 AELHKGDITVRSNEKE-TVFTIAL 349
Cdd:cd16976 79 VEEHGGRLSVANEEGAgARFTFDL 102
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
103-350 |
2.73e-04 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 42.91 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 103 IGELAA---NVNRMAKSLKE-----------------------SIEN------EKKSQE---MKNEMISNISHDLRTPVT 147
Cdd:PRK11107 230 LGELDMlknGINAMAMSLSAyheemqqnidqatsdlretleqmEIQNveldlaKKRAQEaarIKSEFLANMSHELRTPLN 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 148 SLIGYA-DLLGNKLHSNgeeceQ--YVSILKRKSYELKNQVDDLLEYCQINYREIELHKSVVNMKALMEQIMIDFVPQLD 224
Cdd:PRK11107 310 GVIGFTrQTLKTPLTPT-----QrdYLQTIERSANNLLAIINDILDFSKLEAGKLVLENIPFSLRETLDEVVTLLAHSAH 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 225 DADMSLCIKGDKEL--HVEMDVALMVRLFENVISNSIMYGKDGkEIVIQVSKRD-----MNVEIEIKNFGQCIPDENLPY 297
Cdd:PRK11107 385 EKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESG-NIDILVELRAlsntkVQLEVQIRDTGIGISERQQSQ 463
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446617939 298 VFEKFYRGEKSRSSHTGGKGMGLAIARSIAELHKGDITVRSN-EKETVFTIALP 350
Cdd:PRK11107 464 LFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQpNRGSTFWFHLP 517
|
|
| PRK15048 |
PRK15048 |
methyl-accepting chemotaxis protein II; Provisional |
37-123 |
4.44e-04 |
|
methyl-accepting chemotaxis protein II; Provisional
Pssm-ID: 185008 [Multi-domain] Cd Length: 553 Bit Score: 41.92 E-value: 4.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 37 NIYSH-VTALEEKYSF-------LYFIVFLIFTTTYFAcMTKTMMKRLSEINKNVKEIRNGNFEVYIPISKNDEIGELAA 108
Cdd:PRK15048 174 KLYRDiVTDNADDYRFaqwqlavIALVVVLILLVAWYG-IRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQ 252
|
90
....*....|....*
gi 446617939 109 NVNRMAKSLKESIEN 123
Cdd:PRK15048 253 SVSHMQRSLTDTVTH 267
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
253-336 |
6.64e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 41.54 E-value: 6.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSIMYGKDGKEIVIQVSkrDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSshtgGKGMGLAIARSIAELHKG 332
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQT--DEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEG 458
|
....
gi 446617939 333 DITV 336
Cdd:PRK10815 459 KISA 462
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
245-354 |
2.11e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.82 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 245 ALMVRLFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEkfyRGEKSRSSHTGGKGMGLAIAR 324
Cdd:PRK15053 435 AIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRADEPGEHGIGLYLIA 511
|
90 100 110
....*....|....*....|....*....|.
gi 446617939 325 SIAELHKGDITVRSNE-KETVFTIALPQHKK 354
Cdd:PRK15053 512 SYVTRCGGVITLEDNDpCGTLFSIFIPKVKP 542
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
246-340 |
5.32e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 37.32 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 246 LMVRLFENVISNSIMYGKDGKE----IVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFY-------------RGEKS 308
Cdd:cd16929 47 ILFELLKNAMRATVESHGDDSDdlppIKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGT 126
|
90 100 110
....*....|....*....|....*....|..
gi 446617939 309 RSSHTGGKGMGLAIARSIAELHKGDITVRSNE 340
Cdd:cd16929 127 QPSPLAGFGYGLPMSRLYAEYFGGDLDLQSME 158
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-322 |
7.76e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 35.86 E-value: 7.76e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446617939 250 LFENVISNSIMYGKDGKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVfekfyrGEKSRSSHtggKGMGLAI 322
Cdd:cd16957 9 LVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLL------GKTTVTSE---KGTGTAL 72
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-336 |
8.42e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 36.07 E-value: 8.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446617939 253 NVISNSIMYGKdgKEIVIQVSKRDMNVEIEIKNFGQCIPDENLPYVFEKFYRGEKSRSSHtggkGMGLAIARSIAELHKG 332
Cdd:cd16954 44 NLLDNACKWCL--EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQ----GLGLAIAKEIVEQYGG 117
|
....
gi 446617939 333 DITV 336
Cdd:cd16954 118 ELSL 121
|
|
| |
