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Conserved domains on  [gi|446624423|ref|WP_000701769|]
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MULTISPECIES: homoserine dehydrogenase [Bacillus]

Protein Classification

homoserine dehydrogenase( domain architecture ID 11482426)

homoserine dehydrogenase catalyzes the conversion from L-homoserine and NAD(P)(+) to L-aspartate 4-semialdehyde and NAD(P)H

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06813 PRK06813
homoserine dehydrogenase; Validated
 1-341 0e+00

homoserine dehydrogenase; Validated


:

Pssm-ID: 168683 [Multi-domain]  Cd Length: 346  Bit Score: 620.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAIHNEEGLSLHHLLMYGGGTAAIEKYLEYHPKER 80
Cdd:PRK06813   1 MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRYGGGSCAIEKYIEHHPEER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  81 AITSISGTVLVESTVTNLKDGNPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTLDIG 160
Cdd:PRK06813  81 ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 161 QFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKTLTD 240
Cdd:PRK06813 161 QFSLAGCHIEKIEGILNGTTNYILTKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 241 IHIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEGGNVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVTTIGGAS 320
Cdd:PRK06813 241 IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKIEKNHPLANVNGTEKGITFFTDTMGQVTTIGGAS 320

                        330       340
                 ....*....|....*....|.
gi 446624423 321 NPRGAAAAALKDVINLYRKDL 341
Cdd:PRK06813 321 NPRGAAAAALKDIINLYRKDL 341
 
Name Accession Description Interval E-value
PRK06813 PRK06813
homoserine dehydrogenase; Validated
 1-341 0e+00

homoserine dehydrogenase; Validated


Pssm-ID: 168683 [Multi-domain]  Cd Length: 346  Bit Score: 620.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAIHNEEGLSLHHLLMYGGGTAAIEKYLEYHPKER 80
Cdd:PRK06813   1 MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRYGGGSCAIEKYIEHHPEER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  81 AITSISGTVLVESTVTNLKDGNPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTLDIG 160
Cdd:PRK06813  81 ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 161 QFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKTLTD 240
Cdd:PRK06813 161 QFSLAGCHIEKIEGILNGTTNYILTKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 241 IHIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEGGNVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVTTIGGAS 320
Cdd:PRK06813 241 IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKIEKNHPLANVNGTEKGITFFTDTMGQVTTIGGAS 320

                        330       340
                 ....*....|....*....|.
gi 446624423 321 NPRGAAAAALKDVINLYRKDL 341
Cdd:PRK06813 321 NPRGAAAAALKDIINLYRKDL 341
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 22-339 1.84e-89

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 269.99  E-value: 1.84e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  22 NEKYSYIYETYGIQLVVSGVLGRNIAihNEEGLSLHHLLmygggtaaiekyLEYHPKErAITSISGTVLVESTVTnlkdG 101
Cdd:COG0460    1 LENAEELARRLGLDLRVVGVAVRDGM--KPRGIDLPRWL------------LTTDLEE-LIKDPEIDVVVELTGG----S 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 102 NPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTLDIGQFSLAGCSIDKIEGILNGTTN 181
Cdd:COG0460   62 EPARELYLAALEAGKHVVTANKALLAEHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTN 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 182 YILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKTLTDIHIKGIEHVTKQQIQNAKKQH 261
Cdd:COG0460  142 YILTKMEEEGLSFSEALKEAQELGYAEADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELG 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 262 KIIKLIASIYKDEGGnVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVTTIGgasnpRGA-----AAAALKDVINL 336
Cdd:COG0460  222 YVIKLLAIAERTGGG-VEARVHPTLVPADHPLASVNGVDNAVLVETDAYGELMFYG-----PGAgaeptASAVLADLLDI 295


                 ...
gi 446624423 337 YRK 339
Cdd:COG0460  296 ARG 298
Homoserine_dh pfam00742
Homoserine dehydrogenase;
155-333 3.55e-67

Homoserine dehydrogenase;


Pssm-ID: 459921 [Multi-domain]  Cd Length: 178  Bit Score: 208.77  E-value: 3.55e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  155 PTLDIGQFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMET 234
Cdd:pfam00742   1 PIIRTLRLSLAGDRITRIEGILNGTTNYILTRMEEEGLSFSEALKEAQELGYAEADPTDDVEGIDAARKLAILARLAFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  235 EKTLTDIHIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEGGnVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVT 314
Cdd:pfam00742  81 DVELEDVEVEGITRLTAEDIAYAKELGKVIKLVASAKRDDGG-VEARVGPTLVPKDHPLASVKGVDNAVVIETDRYGELV 159

                         170
                  ....*....|....*....
gi 446624423  315 TIGGASNPRGAAAAALKDV 333
Cdd:pfam00742 160 FYGPGAGALPTASAVLADL 178
 
Name Accession Description Interval E-value
PRK06813 PRK06813
homoserine dehydrogenase; Validated
 1-341 0e+00

homoserine dehydrogenase; Validated


Pssm-ID: 168683 [Multi-domain]  Cd Length: 346  Bit Score: 620.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAIHNEEGLSLHHLLMYGGGTAAIEKYLEYHPKER 80
Cdd:PRK06813   1 MKIKVVLSGYGTVGREFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRYGGGSCAIEKYIEHHPEER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  81 AITSISGTVLVESTVTNLKDGNPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTLDIG 160
Cdd:PRK06813  81 ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 161 QFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKTLTD 240
Cdd:PRK06813 161 QFSLAGCHIEKIEGILNGTTNYILTKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 241 IHIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEGGNVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVTTIGGAS 320
Cdd:PRK06813 241 IHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGNVNLNVEPYKIEKNHPLANVNGTEKGITFFTDTMGQVTTIGGAS 320

                        330       340
                 ....*....|....*....|.
gi 446624423 321 NPRGAAAAALKDVINLYRKDL 341
Cdd:PRK06813 321 NPRGAAAAALKDIINLYRKDL 341
PRK06270 PRK06270
homoserine dehydrogenase; Provisional
 1-339 1.27e-94

homoserine dehydrogenase; Provisional


Pssm-ID: 235763 [Multi-domain]  Cd Length: 341  Bit Score: 284.83  E-value: 1.27e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAIHNEEGLSLHHLLMYGGGTAAIEKYLEYHPKER 80
Cdd:PRK06270   1 MEMKIALIGFGGVGQGVAELLAEKREYLKKRYGLDLKVVAIADSSGSAIDPDGLDLELALKVKEETGKLADYPEGGGEIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  81 AITSISGT---VLVESTVTNLKDGNPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTL 157
Cdd:PRK06270  81 GLEVIRSVdadVVVEATPTNIETGEPALSHCRKALERGKHVVTSNKGPLALAYKELKELAKKNGVRFRYEATVGGAMPII 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 158 DIGQFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKT 237
Cdd:PRK06270 161 NLAKETLAGNDIKSIKGILNGTTNYILTRMEEEGLSYEQALAEAQELGYAEADPTYDVEGIDAALKVVILANSILGADLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 238 LTDIHIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEggnvNLNVEPCEIEKDHPLAkVNGTEKGITFFTDTMGQVTTIG 317
Cdd:PRK06270 241 IKDVEVEGITKITPEAIELAAKEGYRIKLIGEVSREK----DLSVSPRLVPLDHPLA-VSGTLNAATFETDLAGDVTVVG 315

                        330       340
                 ....*....|....*....|..
gi 446624423 318 GASNPRGAAAAALKDVINLYRK 339
Cdd:PRK06270 316 RGAGSIETASAILSDLIAIHDR 337
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 22-339 1.84e-89

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 269.99  E-value: 1.84e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  22 NEKYSYIYETYGIQLVVSGVLGRNIAihNEEGLSLHHLLmygggtaaiekyLEYHPKErAITSISGTVLVESTVTnlkdG 101
Cdd:COG0460    1 LENAEELARRLGLDLRVVGVAVRDGM--KPRGIDLPRWL------------LTTDLEE-LIKDPEIDVVVELTGG----S 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 102 NPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTLDIGQFSLAGCSIDKIEGILNGTTN 181
Cdd:COG0460   62 EPARELYLAALEAGKHVVTANKALLAEHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTN 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 182 YILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKTLTDIHIKGIEHVTKQQIQNAKKQH 261
Cdd:COG0460  142 YILTKMEEEGLSFSEALKEAQELGYAEADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELG 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 262 KIIKLIASIYKDEGGnVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVTTIGgasnpRGA-----AAAALKDVINL 336
Cdd:COG0460  222 YVIKLLAIAERTGGG-VEARVHPTLVPADHPLASVNGVDNAVLVETDAYGELMFYG-----PGAgaeptASAVLADLLDI 295


                 ...
gi 446624423 337 YRK 339
Cdd:COG0460  296 ARG 298
Homoserine_dh pfam00742
Homoserine dehydrogenase;
155-333 3.55e-67

Homoserine dehydrogenase;


Pssm-ID: 459921 [Multi-domain]  Cd Length: 178  Bit Score: 208.77  E-value: 3.55e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  155 PTLDIGQFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMET 234
Cdd:pfam00742   1 PIIRTLRLSLAGDRITRIEGILNGTTNYILTRMEEEGLSFSEALKEAQELGYAEADPTDDVEGIDAARKLAILARLAFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  235 EKTLTDIHIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEGGnVNLNVEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVT 314
Cdd:pfam00742  81 DVELEDVEVEGITRLTAEDIAYAKELGKVIKLVASAKRDDGG-VEARVGPTLVPKDHPLASVKGVDNAVVIETDRYGELV 159

                         170
                  ....*....|....*....
gi 446624423  315 TIGGASNPRGAAAAALKDV 333
Cdd:pfam00742 160 FYGPGAGALPTASAVLADL 178
PRK06349 PRK06349
homoserine dehydrogenase; Provisional
 1-298 1.10e-46

homoserine dehydrogenase; Provisional


Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 163.32  E-value: 1.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAihneeglslhhllmygggtaaiekyleyhpKER 80
Cdd:PRK06349   2 KPLKVGLLGLGTVGSGVVRILEENAEEIAARAGRPIEIKKVAVRDLE------------------------------KDR 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  81 AItSISGTVLVESTVTNLKDGN------------PGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSG 148
Cdd:PRK06349  52 GV-DLPGILLTTDPEELVNDPDidivvelmggiePARELILKALEAGKHVVTANKALLAVHGAELFAAAEEKGVDLYFEA 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 149 ATAAALPTLDIGQFSLAGCSIDKIEGILNGTTNYILTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLT 228
Cdd:PRK06349 131 AVAGGIPIIKALREGLAANRITRVMGIVNGTTNYILTKMTEEGLSFEDALKEAQRLGYAEADPTFDVEGIDAAHKLAILA 210

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446624423 229 nSL-METEKTLTDIHIKGIEHVTKQQIQNAKKQHKIIKLIAsIYKDEGGNVNLNVEPCEIEKDHPLAKVNG 298
Cdd:PRK06349 211 -SLaFGTRVDFDDVYVEGISKITAEDIAYAKELGYRIKLLG-IAERTEEGIELRVHPTLIPKSHPLANVNG 279
PRK08374 PRK08374
homoserine dehydrogenase; Provisional
 1-334 1.70e-40

homoserine dehydrogenase; Provisional


Pssm-ID: 169409 [Multi-domain]  Cd Length: 336  Bit Score: 144.95  E-value: 1.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAIHNEEGLSLHHLLMYGGGTAAI-------EKYl 73
Cdd:PRK08374   1 MEVKVSIFGFGNVGRAVAEVLAEKSRVFKERYGVELKVVSITDTSGTIWLPEDIDLREAKEVKENFGKLsnwgndyEVY- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  74 EYHPKErAITSISGTVLVEstVTNLKDGNpgkQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAA 153
Cdd:PRK08374  80 NFSPEE-IVEEIDADIVVD--VTNDKNAH---EWHLEALKEGKSVVTSNKPPIAFHYDELLDLANERNLPYLFEATVMAG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 154 LPTLDIGQFSLAGCSIDKIEGILNGTTNYILTKMyEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLME 233
Cdd:PRK08374 154 TPIIGLLRENLLGDTVKRIEAVVNATTTFILTRM-EQGKTFEEALKEAQTLGIAERDPSKDIDGIDAGYKATILHWVAFP 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 234 TEkTLTDIHIKGIEHVTKQQIQNAKKQHKIIKLIASIykdEGGNVnlNVEPCEIEKDHPLAkVNGTEKGITFFTDTMGQV 313
Cdd:PRK08374 233 PI-TFEEVGIRGIKDVTEGEIERAKAKGRNVRLVATV---EEGRI--SVKPKKLPENSPLA-VEGVENAAVIKTDLLGEL 305

                        330       340
                 ....*....|....*....|.
gi 446624423 314 TTIGGASNPRGAAAAALKDVI 334
Cdd:PRK08374 306 VLKGPGAGGKETASGVVTDII 326
PRK06392 PRK06392
homoserine dehydrogenase; Provisional
 3-336 6.18e-29

homoserine dehydrogenase; Provisional


Pssm-ID: 102354 [Multi-domain]  Cd Length: 326  Bit Score: 113.81  E-value: 6.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   3 IQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVvsGVLGRNIAIHNEEGLSLHHLLMYG-GGTAAIEKYLEYHPKEra 81
Cdd:PRK06392   1 IRISIIGLGNVGLNVLRIIKSRNDDRRNNNGISVV--SVSDSKLSYYNERGLDIGKIISYKeKGRLEEIDYEKIKFDE-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  82 ITSISGTVLVESTVTNlKDGNPGKQYMKQAIEKQMDIVAISKGALVTNWREINEAARGANVRIRYSGATAAALPTLDIGQ 161
Cdd:PRK06392  77 IFEIKPDVIVDVTPAS-KDGIREKNLYINAFEHGIDVVTANKSGLANHWHDIMDSASKNRRIIRYEATVAGGVPLFSLRD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 162 FSLAGCSIDKIEGILNGTTNYILTKMYEEdMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSLMETEKTLTDI 241
Cdd:PRK06392 156 YSTLPSRIKNFRGIVSSTINYVIRQEANG-RGFLDVVKIAQKMGIAETNYSDDLMGLDAARKSVILANHLFGKDYTLRDV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 242 HIKGIEHVTKQQIQNAkkqhkiiKLIASIYKDEGGNVNLNvEPCEIEKDHPLAKVNGTEKGITFFTDTMGQVTTIGGASN 321
Cdd:PRK06392 235 TYDGIENIDRSSMDNE-------RLVTEVAMINGGPHAES-RIRSLSRNDFLGMIGPLSLGYQMETDINGTINVSDNYDG 306

                        330
                 ....*....|....*
gi 446624423 322 PRGAAAAALKDVINL 336
Cdd:PRK06392 307 PYETAGAVVNDVMLL 321
thrA PRK09436
bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
 2-308 1.52e-25

bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional


Pssm-ID: 181856 [Multi-domain]  Cd Length: 819  Bit Score: 107.55  E-value: 1.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   2 KIQVVLSGYGTVGREFIKLLNEKYSYIYETyGIQLVVSGVLGRNIAIHNEEGLSLHH---LLMYGGGTAAIEKYLEyHPK 78
Cdd:PRK09436 465 VLDVFVIGVGGVGGALLEQIKRQQPWLKKK-NIDLRVCGIANSRKMLLDEHGIDLDNwreELAEAGEPFDLDRLIR-LVK 542

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  79 ERaitSISGTVLVESTvtnlKDGNPGKQYmKQAIEKQMDIVAISKGALVTNW---REINEAARGANVRIRYSGATAAALP 155
Cdd:PRK09436 543 EY---HLLNPVIVDCT----SSQAVADQY-ADFLAAGFHVVTPNKKANTSSYayyHQLREAARKSRRKFLYETNVGAGLP 614

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 156 TLDIGQfSL--AGCSIDKIEGILNGTTNYILTKmYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLLLTNSL-M 232
Cdd:PRK09436 615 VIETLQ-NLlnAGDELLKFEGILSGSLSFIFGK-LDEGMSFSEATRLAKEKGYTEPDPRDDLSGMDVARKLLILAREAgY 692

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 233 ETEktLTDIHIKGI--EHVT-------------------KQQIQNAKKQHKIIKLIASIykdEGGNVNLNVEpcEIEKDH 291
Cdd:PRK09436 693 ELE--LEDIEVESVlpEEFDasgsvdefmarlpeldaefAARVAKARAEGKVLRYVGQI---EDGKCRVGIA--EVDANH 765

                        330
                 ....*....|....*..
gi 446624423 292 PLAKVNGTEKGITFFTD 308
Cdd:PRK09436 766 PLYKVKGGENALAFYTR 782
metL PRK09466
bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional
 1-294 8.13e-10

bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional


Pssm-ID: 236530 [Multi-domain]  Cd Length: 810  Bit Score: 59.94  E-value: 8.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   1 MKIQVVLSGYGTVGREFIKLLNEKYSYIYETYGIQLVVSGVLGRNIAIHNEEGLSLHHLLMYGGGTAAIEKY------LE 74
Cdd:PRK09466 457 KRIGLVLFGKGNIGSRWLELFAREQSTLSARTGFEFVLVGVVDSRRSLLNYDGLDASRALAFFDDEAVEWDEeslflwLR 536

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  75 YHPKERAItsisgtVLvesTVTNLKDgnPGKQYMKQAiEKQMDIVAISK--GALVTNW-REINEAARGANVRIRYSGATA 151
Cdd:PRK09466 537 AHPYDELV------VL---DVTASEQ--LALQYPDFA-SHGFHVISANKlaGSSPSNFyRQIKDAFAKTGRHWLYNATVG 604

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 152 AALPTldigQFSLA-----GCSIDKIEGILNGTTNYiLTKMYEEDMTFEEALKEAQNKGIAETNPILDISGSDSACKLLL 226
Cdd:PRK09466 605 AGLPI----NHTVRdlrnsGDSILAISGIFSGTLSW-LFLQFDGSVPFSELVDQAWQQGLTEPDPRDDLSGRDVMRKLVI 679

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 227 LT--------------NSLMETEktLTDI-------HIKGIEHVTKQQIQNAKKQHKIIKLIASIYKDEGGNVNLNVepc 285
Cdd:PRK09466 680 LAreagyeiepddvrvESLVPAH--LEDGsldqffeNGDELDEQMLQRLEAAAEQGKVLRYVARFDANGKARVGVEA--- 754


                 ....*....
gi 446624423 286 eIEKDHPLA 294
Cdd:PRK09466 755 -VRPDHPLA 762
PLN02700 PLN02700
homoserine dehydrogenase family protein
 2-336 3.82e-08

homoserine dehydrogenase family protein


Pssm-ID: 215377 [Multi-domain]  Cd Length: 377  Bit Score: 54.39  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423   2 KIQVVLSGYGTVGREFIKLLNEKYSyIYETYGIQLVVSGV-------LGRNIaiHNEE----GLSLHHLLMYGG-----G 65
Cdd:PLN02700   3 KIPVLLLGCGGVGRHLLRHIVSCRS-LHAKQGVRIRVVGVcdskslvLAEDV--LNEElddaLLSEVCLAKSKGsplsaL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423  66 TAAIEKYLEYHPKERAITSI---------SGTVLVESTVTnLKDGnpgkQYMKQAIEKQMDIVAISKGALVTNWREINEA 136
Cdd:PLN02700  80 GALAGGCQVFNNSELSRKVIdiatllgksTGLVVVDCSAS-METI----GALNEAVDLGCCIVLANKKPLTSTLEDYDKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 137 ArGANVRIRYSGATAAALPTL-DIGQFSLAGCSIDKIEGILNGTTNYILTKMyEEDMTFEEALKEAQNKGIAETNPILDI 215
Cdd:PLN02700 155 A-AHPRRIRHESTVGAGLPVIaSLNRILSSGDPVHRIVGSLSGTLGYVMSEL-EDGKPFSEVVKQAKSLGYTEPDPRDDL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446624423 216 SGSDSACKLLLLTnSLMETEKTLTDIHIK--------------------GIEHVTK---QQIQNAKKQHKIIKLIASIyk 272
Cdd:PLN02700 233 GGMDVARKALILA-RLLGKRINMDSIKVEslypeemgpdlmstddflhsGLVELDLpieERVKEASLKGCVLRYVCVI-- 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446624423 273 dEGGNVNLNVEpcEIEKDHPLAKVNGTEKGITFFT---DTMGQVTTIGGASNPRgAAAAALKDVINL 336
Cdd:PLN02700 310 -EGSSCQVGIR--ELPKDSALGRLRGSDNVVEIYSrcySEQPLVIQGAGAGNDT-TAAGVLADILDL 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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